A Narrative Review on Metal-Organic Frameworks as Dual-Functional Nanocarriers: Advancing Chemo-Photothermal Therapy for Precision Cancer Treatment.

Abstract

Background: Metal-organic frameworks (MOFs) have emerged as promising multifunctional nanocarriers in cancer therapy due to their high porosity, tunable architecture, and ability to integrate dual treatment modalities. Objective: Among these, MOF-based chemo-photothermal therapy (CPTT) has gained significant attention as it enhances the efficacy of traditional chemotherapy through localized hyperthermia, thereby overcoming drug resistance and improving tumor targeting. Materials and Methods: MOFs can encapsulate chemotherapeutic agents while simultaneously acting as photothermal conversion agents upon near-infrared irradiation. Results: This mini-review explores the recent advancements in MOF-based CPTT, highlighting key developments such as stimuli-responsive drug release, metal-enhanced photothermal effects, and hybrid MOF nanostructures. Furthermore, we discuss their potential for theranostic applications, integrating imaging and therapy, and address the key challenges associated with biocompatibility, stability, and clinical translation. The enhanced therapeutic efficacy, biocompatibility, and remarkable targeting make the system as dual system for theranostics as well as targeting purpose. Conclusions: The future of MOF-based CPTT lies in the development of biodegradable, targeted, and multifunctional MOFs, offering a pathway toward personalized, precision-driven oncological treatments.