Obesity (Silver Spring, Md.)最新文献_第2页

Association of BMI and Cognitive Performance in the Diabetes Prevention Program Outcomes Study. 糖尿病预防项目结果研究中BMI与认知表现的关系

Obesity (Silver Spring, Md.) Pub Date : 2025-09-28 DOI: 10.1002/oby.70031

José A Luchsinger, Qing Pan, William C Knowler, Medha Munshi, Karol Watson, Kishore M Gadde, Mathias Schlögl, Owen T Carmichael

{"title":"Association of BMI and Cognitive Performance in the Diabetes Prevention Program Outcomes Study.","authors":"José A Luchsinger, Qing Pan, William C Knowler, Medha Munshi, Karol Watson, Kishore M Gadde, Mathias Schlögl, Owen T Carmichael","doi":"10.1002/oby.70031","DOIUrl":"https://doi.org/10.1002/oby.70031","url":null,"abstract":"Objective: This study aimed to examine the association of BMI with cognitive performance in individuals with diabetes or prediabetes.Methods: Among Diabetes Prevention Program Outcomes Study (DPPOS) participants, BMI was categorized as normal (< 25 kg/m2), overweight (25 to < 30 kg/m2), or obesity (≥ 30 kg/m2). Cognitive tests included the Brief Spanish English Verbal Learning Test (B-SEVLT) and the Digit Symbol Substitution test (DSST). The relationship between BMI at DPPOS Year 8 (Y8) visit and cognitive test scores at Y8, Y10, and Y15 visits was ascertained via linear mixed models accounting for repeated measures. Analogous models related BMI to Modified Mini-Mental State exam (3MS) score at Y15.Results: A total of 2285 participants (mean ± SD age 51.1 ± 10.0 years; 67.7% female; 31% with overweight; and 60% with obesity at DPPOS Y8) completed cognitive assessments. Those with overweight or obesity at Y8 had a slower decline in B-SEVLT immediate and delayed recall, compared with those with normal BMI; 3MS performance was higher among individuals with overweight or obesity compared to those with normal BMI at Y15.Conclusions: Among individuals with prediabetes or diabetes in DPPOS, overweight or obesity was associated with slower decline in verbal learning and memory compared with those with normal BMI.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Frontiers in Stand-Alone Digital Obesity Treatment. 独立数字肥胖治疗的新领域。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-28 DOI: 10.1002/oby.70060

Delia S West, Rebecca A Krukowski

引用次数: 0

Body Roundness Index Associated With Cardiometabolic Multimorbidity and Mortality: A Multistate Model. 身体圆度指数与心脏代谢疾病和死亡率相关：一个多状态模型。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-28 DOI: 10.1002/oby.70032

Xi Cai, Yicheng Liao, Xuemei Yang, Yajing Liang, Jiajia Ma, Ruiyue Liu, Xinran Wen, Wenli Yin, Shuohua Chen, Guodong Wang, Na Li, Shouling Wu, Liufu Cui

{"title":"Body Roundness Index Associated With Cardiometabolic Multimorbidity and Mortality: A Multistate Model.","authors":"Xi Cai, Yicheng Liao, Xuemei Yang, Yajing Liang, Jiajia Ma, Ruiyue Liu, Xinran Wen, Wenli Yin, Shuohua Chen, Guodong Wang, Na Li, Shouling Wu, Liufu Cui","doi":"10.1002/oby.70032","DOIUrl":"https://doi.org/10.1002/oby.70032","url":null,"abstract":"Objective: This study aimed to investigate the associations of body roundness index (BRI) with cardiometabolic disease (CMD), cardiometabolic multimorbidity (CMM), and all-cause mortality, while evaluating its impact across different stages of CMM progression.Methods: In this prospective cohort study, 87,902 participants from the Kailuan cohort were categorized into BRI quartiles. Cox models estimated hazard ratios (HRs) and 95% CIs for the first occurrence of cardiometabolic disease (FCMD), CMM, and mortality. Multistate models assessed BRI's role across CMM progression.Results: Over a median follow-up of 13.68 years, 21,636 participants developed FCMD, 2114 developed CMM, and 14,782 died. Elevated BRI increased risks of FCMD, CMM, and mortality in Cox models. Multistate analysis revealed differential BRI effects across CMM progression: participants in the highest versus lowest BRI quartile showed HRs of 2.08 (1.99-2.17) for healthy-to-FCMD transition, 1.61 (1.38-1.88) for FCMD-to-CMM transition, and 1.09 (1.03-1.16), 0.99 (0.89-1.10), and 0.73 (0.54-0.99) for mortality from the healthy state, FCMD, and CMM, respectively. BRI's impact varied by disease type (diabetes mellitus, myocardial infarction, stroke) and sex, with stronger associations in females.Conclusions: Our findings emphasize dynamic BRI monitoring as a biomarker for early CMM risk identification and prognostic assessment, necessitating disease- and sex-specific prevention strategies.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-Restricted Access to High-Fat Diet Influences Weight Gain, Meal Patterns, and Food Preference. 高脂肪饮食的时间限制会影响体重增加、饮食模式和食物偏好。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-25 DOI: 10.1002/oby.70030

Payam A Fathi, Michelle B Bales, Pranav Sathu, Julio E Ayala

{"title":"Time-Restricted Access to High-Fat Diet Influences Weight Gain, Meal Patterns, and Food Preference.","authors":"Payam A Fathi, Michelle B Bales, Pranav Sathu, Julio E Ayala","doi":"10.1002/oby.70030","DOIUrl":"https://doi.org/10.1002/oby.70030","url":null,"abstract":"Objective: Access to only high-fat diet (HFD) during the light versus dark cycle promotes different metabolic outcomes. We assessed changes in body weight/composition, feeding behavior, and metabolic parameters in mice fed HFD during the light or dark cycle with concomitant ad libitum access to chow.Methods: Male C57BL/6J mice were housed in metabolic chambers with two hoppers containing chow. HFD was then provided in one hopper, with access restricted to the light or dark cycle. The other hopper provided ad libitum access to chow. Food intake, meal patterns, energy expenditure, activity, and substrate oxidation were measured for ~4 weeks. Body weight/composition was measured before and after ~4-week HFD access.Results: Light cycle HFD access promoted greater weight and fat mass gain. Although daily caloric intake was equivalent between groups, light cycle HFD access increased preference for HFD and intake of larger, more frequent HFD meals during the daytime. Dark cycle HFD access promoted preference for chow and consumption of larger, more frequent chow meals.Conclusions: Light cycle HFD access parallels detrimental metabolic outcomes of ad libitum HFD access. Dark cycle HFD access reduces weight gain and adiposity; this is associated with enhanced chow preference.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One Year of Exercise After Weight Loss Increases Postprandial GLP-1 Secretion in Contrast to Usual Activity or GLP-1 Receptor Agonist Treatment. 与正常活动或GLP-1受体激动剂治疗相比，减肥后运动一年增加餐后GLP-1分泌

Obesity (Silver Spring, Md.) Pub Date : 2025-09-25 DOI: 10.1002/oby.70043

Joachim Holt, Rasmus Michael Sandsdal, Sarah Byberg, Charlotte Janus, Christian Rimer Juhl, Julie Rehné Jørgensen, Bolette Hartmann, Bente Stallknecht, Jens Juul Holst, Sten Madsbad, Simon Birk Kjær Jensen, Signe Sørensen Torekov

{"title":"One Year of Exercise After Weight Loss Increases Postprandial GLP-1 Secretion in Contrast to Usual Activity or GLP-1 Receptor Agonist Treatment.","authors":"Joachim Holt, Rasmus Michael Sandsdal, Sarah Byberg, Charlotte Janus, Christian Rimer Juhl, Julie Rehné Jørgensen, Bolette Hartmann, Bente Stallknecht, Jens Juul Holst, Sten Madsbad, Simon Birk Kjær Jensen, Signe Sørensen Torekov","doi":"10.1002/oby.70043","DOIUrl":"https://doi.org/10.1002/oby.70043","url":null,"abstract":"Objective: Incretin-based obesity medication maintains weight loss by mimicking the appetite-inhibiting hormone GLP-1. Interestingly, chronic exercise may improve postprandial appetite control by increasing late postprandial secretion of endogenous GLP-1. Therefore, we investigated whether an exercise program after weight loss could increase late-phase postprandial GLP-1 secretion.Methods: This study is an exploratory analysis of adults with obesity (n = 195) who lost 13.1 kg on a low-calorie diet and were randomized to 52 weeks of either usual activity, moderate-to-vigorous intensity exercise, the GLP-1 receptor agonist liraglutide (3.0 mg/day), or the combination. The primary endpoint was change in late-phase GLP-1 response to a 3-h liquid mixed meal test before and after diet-induced weight loss and after 1 year of intervention.Results: Diet-induced weight loss did not change late-phase GLP-1 response (3%; 95% CI, -4%-10%). One year of exercise increased late-phase postprandial GLP-1 response within the group by 37% (95% CI, 20%-57%), and this increase was 25% greater (95% CI, 3%-51%, p = 0.02) compared to the usual activity group. Late-phase postprandial GLP-1 response was unchanged in both groups treated with GLP-1 receptor agonist compared to placebo.Conclusions: One year of exercise increased late-phase postprandial GLP-1 response, which may prevent increased appetite after weight loss and thereby weight regain.Trial registration: EudraCT number: 2015-005585-32; ClinicalTrials.gov identifier: NCT04122716.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Maternal Prepregnancy BMI With Offspring Cardiometabolic Outcomes in Childhood. 母亲孕前体重指数与儿童时期后代心脏代谢结局的关系

Obesity (Silver Spring, Md.) Pub Date : 2025-09-21 DOI: 10.1002/oby.70028

Rachana Singh, Christopher B Pierce, Kartikeya Makker, Lisa Jacobson, Elizabeth T Jensen, Ruben Vaidya, Semsa Gogcu, Keia Sanderson, Andrew M South, Amanda Thompson, Wei Perng, Eliana M Perrin, Andrea E Cassidy-Bushrow, Anne L Dunlop, Dana Dabelea, Assiamira Ferrara, Monique M Hedderson, Yeyi Zhu, Margaret Karagas, Carlos A Camargo, Christine W Hockett, Izzuddin M Aris, Cindy T McEvoy, Jody M Ganiban, Shohreh Farzan, Monica Serrano-Gonzalez, Susan Carnell, Sarah D Geiger, Qi Zhao, T Michael O'Shea

{"title":"Association of Maternal Prepregnancy BMI With Offspring Cardiometabolic Outcomes in Childhood.","authors":"Rachana Singh, Christopher B Pierce, Kartikeya Makker, Lisa Jacobson, Elizabeth T Jensen, Ruben Vaidya, Semsa Gogcu, Keia Sanderson, Andrew M South, Amanda Thompson, Wei Perng, Eliana M Perrin, Andrea E Cassidy-Bushrow, Anne L Dunlop, Dana Dabelea, Assiamira Ferrara, Monique M Hedderson, Yeyi Zhu, Margaret Karagas, Carlos A Camargo, Christine W Hockett, Izzuddin M Aris, Cindy T McEvoy, Jody M Ganiban, Shohreh Farzan, Monica Serrano-Gonzalez, Susan Carnell, Sarah D Geiger, Qi Zhao, T Michael O'Shea","doi":"10.1002/oby.70028","DOIUrl":"https://doi.org/10.1002/oby.70028","url":null,"abstract":"Objective: This study aimed to evaluate associations of maternal prepregnancy BMI with offspring BMI and blood pressure in childhood, specifically for infants born preterm.Methods: In this observational cohort study of children in the Environmental Influences on Child Health Outcomes (ECHO) Cohort, we utilized four levels of maternal prepregnancy BMI and child BMI. Children were categorized as being born extremely, very, or moderately preterm; late preterm; or term.Results: In total, 13,810 children from 44 ECHO cohorts were included in these analyses. After adjusting for maternal education, maternal age at delivery, and singleton birth, a monotonic dose relationship was noted between child BMI z-scores and maternal prepregnancy BMI level. For child blood pressure outcomes, only extremely preterm children born to mothers with healthy weight and obesity and very/moderately preterm children born to mothers with healthy weight had higher odds of elevated blood pressure/hypertension compared with their term counterparts.Conclusions: High maternal prepregnancy BMI was associated with a stepwise increase in offspring BMI in childhood. Preterm children had a higher probability of elevated blood pressure/hypertension than term children. These findings highlight a possible window of opportunity to modify lifestyles and behavior of at-risk children prior to adolescence to positively impact adolescent cardiometabolic health.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Neighborhood Redevelopment Reduce Obesity? Evidence From Jordan Downs in Watts, Los Angeles. 社区重建能减少肥胖吗？证据来自洛杉矶瓦茨的乔丹·唐斯。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-18 DOI: 10.1002/oby.70025

Tadeja Gracner, Victoria Shier, Jose J Scott, Ying Liu, Ashlesha Datar

{"title":"Does Neighborhood Redevelopment Reduce Obesity? Evidence From Jordan Downs in Watts, Los Angeles.","authors":"Tadeja Gracner, Victoria Shier, Jose J Scott, Ying Liu, Ashlesha Datar","doi":"10.1002/oby.70025","DOIUrl":"https://doi.org/10.1002/oby.70025","url":null,"abstract":"Objective: This study aimed to evaluate the early effects of a comprehensive redevelopment of a low-income, minority community on adult obesity.Methods: We analyzed longitudinal data on a cohort of public housing residents from Jordan Downs (JD), the community undergoing redevelopment, and a comparison group in Watts, Los Angeles, California. Difference-in-difference models with individual fixed effects were estimated on a sample of 421 adults comparing changes in BMI and waist circumference for JD versus comparison group residents between baseline (2018-2019) and follow-up (2021-2022). Quasi-experimental variation in redevelopment exposure was used to assess dose-response relationships. Secondary outcomes included diet and physical activity barriers and behaviors.Results: There were no significant differences in BMI or waist circumference changes between JD residents (n = 279) and the comparison group (n = 149) overall. Within JD, those who moved to redeveloped areas (n = 75) experienced a 2.2% larger reduction in waist circumference (95% CI: -0.05 to -0.003) and a 10.6 percentage point (95% CI: -0.20 to -0.02) greater decline in abdominal obesity, relative to the comparison group. They reported greater declines in barriers to healthy eating and exercise, along with reduced added sugar intake, but no differential changes in BMI, obesity, physical activity, or diet quality.Conclusions: Redeveloping low-income communities can reduce abdominal obesity.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Five Novel Intervention Components in Online Obesity Treatment: Outcomes of a Randomized Factorial Experiment. 在线肥胖治疗中五种新型干预成分的评价：随机析因实验的结果。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-18 DOI: 10.1002/oby.70039

J Graham Thomas, Carly M Goldstein, Dale S Bond, Jason Lillis, Eric Hekler, Stephanie P Goldstein, Meghan L Butryn, Zihuan Cao, Rena R Wing

{"title":"Evaluation of Five Novel Intervention Components in Online Obesity Treatment: Outcomes of a Randomized Factorial Experiment.","authors":"J Graham Thomas, Carly M Goldstein, Dale S Bond, Jason Lillis, Eric Hekler, Stephanie P Goldstein, Meghan L Butryn, Zihuan Cao, Rena R Wing","doi":"10.1002/oby.70039","DOIUrl":"https://doi.org/10.1002/oby.70039","url":null,"abstract":"Objective: This study aimed to optimize weight loss outcomes in an online behavioral obesity treatment program by evaluating the effects of five novel intervention components using a factorial experiment informed by the multiphase optimization strategy framework.Methods: A randomized factorial experiment tested 12-month weight loss resulting from an established online obesity treatment program with randomization to zero to five novel intervention components (interactive video feedback, tailored intervention to promote physical activity, skills for dysregulated eating, virtual reality skills training, and social support with friendly competition).Results: Adults (N = 384; 83% female, 12% male, 5% another sex/gender or did not disclose; 23% racial and/or ethnic minority) with (mean ± SD) age of 53.5 ± 11.7 years and BMI of 35.0 ± 6.1 kg/m2 were randomized. No intervention component independently improved weight loss (p values > 0.199). Interaction terms (p values < 0.01) suggest the combination of interactive video feedback, skills for dysregulated eating, and social support with friendly competition improved weight loss. Mediation analysis indicated that social support and dysregulated eating interventions influenced weight loss outcomes through improvements in social support for physical activity and dietary quality.Conclusions: This study identified a combination of intervention components that may improve weight loss outcomes compared to the established online treatment program.Trial registration: ClinicalTrials.gov identifier NCT04520256.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-Term Weight Loss Outcomes of 1.0 mg Semaglutide Therapy Initiated 6 Months After Sleeve Gastrectomy. 套袖胃切除术后6个月开始1.0 mg西马鲁肽治疗的短期体重减轻结果。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-18 DOI: 10.1002/oby.70006

Mengcheng He, Yu Wang, Rong Hua, Chong Cao, Bo Xu, Qiwei Shen, Xiaojian Fu, Yikai Shao, Qiyuan Yao

{"title":"Short-Term Weight Loss Outcomes of 1.0 mg Semaglutide Therapy Initiated 6 Months After Sleeve Gastrectomy.","authors":"Mengcheng He, Yu Wang, Rong Hua, Chong Cao, Bo Xu, Qiwei Shen, Xiaojian Fu, Yikai Shao, Qiyuan Yao","doi":"10.1002/oby.70006","DOIUrl":"https://doi.org/10.1002/oby.70006","url":null,"abstract":"Objective: This study aimed to evaluate the weight loss efficacy of semaglutide initiated 6 months after laparoscopic sleeve gastrectomy (LSG).Methods: This retrospective study included patients undergoing primary LSG. Patients receiving semaglutide (1.0 mg weekly) at 6 months post LSG for 6 months were matched 1:3 with controls not receiving semaglutide, balancing demographics, preoperative BMI, waist-hip ratio, comorbidities, and total weight loss (TWL) at 6 months post surgery. Primary outcomes were absolute and percentage weight loss from 6 to 12 months post LSG.Results: Both the treatment (n = 34) and control (n = 102) groups achieved substantial TWL (23.16% ± 6.50% vs. 23.53% ± 4.87%) at 6 months post LSG. From 6 to 12 months, the treatment group experienced significantly greater absolute (14.03 ± 5.26 kg vs. 5.63 ± 6.25 kg; p < 0.0001) and percentage (12.61% ± 4.11% vs. 4.84% ± 5.18%; p < 0.0001) weight loss than controls. At 12 months, TWL was also higher in the treatment group (35.77% ± 8.35% vs. 28.37% ± 7.41%; p < 0.0001).Conclusions: Semaglutide initiated 6 months post LSG significantly enhances short-term postoperative weight loss, even among patients who have already achieved substantial initial weight loss. These findings suggest its potential as an effective adjunct therapy for optimizing weight management in early postoperative care.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality? 肥胖的精准预防、诊断和治疗：白日梦还是现实？

Obesity (Silver Spring, Md.) Pub Date : 2025-09-18 DOI: 10.1002/oby.70015

Emily K Woolf, Hanim E Diktas, Andres Acosta, John W Apolzan, Jamy D Ard, Kristen E Boyle, Jack A Gilbert, Peter T Katzmarzyk, Paul J Laurienti, Tim Lobstein, Holly L Nicastro, Jose M Ordovas, Suzanne Phelan, Leanne M Redman, Brian E Roe, Donna H Ryan, Jacqueline M Stephens, Deborah F Tate, Caroline M Apovian, Corby K Martin

{"title":"Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?","authors":"Emily K Woolf, Hanim E Diktas, Andres Acosta, John W Apolzan, Jamy D Ard, Kristen E Boyle, Jack A Gilbert, Peter T Katzmarzyk, Paul J Laurienti, Tim Lobstein, Holly L Nicastro, Jose M Ordovas, Suzanne Phelan, Leanne M Redman, Brian E Roe, Donna H Ryan, Jacqueline M Stephens, Deborah F Tate, Caroline M Apovian, Corby K Martin","doi":"10.1002/oby.70015","DOIUrl":"https://doi.org/10.1002/oby.70015","url":null,"abstract":"Precision medicine approaches have gained attention for their potential to more effectively manage obesity by tailoring diagnosis and treatment strategies to individual characteristics, including genetic background, phenotypes, metabolic profiles, and environmental exposures. The current review evaluates the evidence for precision medicine in weight management by summarizing the proceedings of a Pennington Biomedical Scientific Symposium titled \"Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?\" This review discusses the extent to which we can classify and predict obesity risk based on individual-level factors; whether we have the diagnostic capability to prospectively identify people who will benefit most from specific interventions; whether prospective trials demonstrate superior prevention and treatment of obesity when precision approaches are applied; and whether evidence is sufficient to guide policy decisions. Expert opinions were presented on the current evidence of precision medicine for obesity to collectively evaluate key barriers and opportunities for implementation of precision approaches in clinical and public health settings.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0