Obesity (Silver Spring, Md.)最新文献_第2页

The Effect of a Very Low-Carbohydrate Diet on Intermuscular Adipose Tissue and Muscle Function in Older Adults With Obesity. 极低碳水化合物饮食对老年肥胖患者肌间脂肪组织和肌肉功能的影响。

Obesity (Silver Spring, Md.) Pub Date : 2026-10-06 DOI: 10.1002/oby.70316

Carly E Drake, Barbara A Gower, Kevin R Fontaine, David R Bryan, Amy M Goss

{"title":"The Effect of a Very Low-Carbohydrate Diet on Intermuscular Adipose Tissue and Muscle Function in Older Adults With Obesity.","authors":"Carly E Drake, Barbara A Gower, Kevin R Fontaine, David R Bryan, Amy M Goss","doi":"10.1002/oby.70316","DOIUrl":"https://doi.org/10.1002/oby.70316","url":null,"abstract":"Objective: Intermuscular adipose tissue (IMAT) is associated with impaired skeletal muscle (SM) quality and declining mobility in older adults with obesity. This secondary analysis examined the effects of a very low-carbohydrate diet (VLCD) versus a low-fat diet (LFD) on changes in IMAT, muscle strength, and physical function in older adults with obesity.Methods: Adults (age ≥ 60 years) with obesity were randomized to a weight-maintaining VLCD (< 10% energy from carbohydrates) or LFD (55% energy from carbohydrates) for 8 weeks. Thigh SM and IMAT were measured by MRI. Physical function was assessed via hand grip strength, isometric knee extension, reach score, and six-minute walk tests. Multiple linear regressions examined whether changes in IMAT were associated with changes in physical function outcomes.Results: The VLCD group showed a significantly greater decrease in IMAT (-24.4% vs. -1.0%, p < 0.01). Across all participants, greater decreases in IMAT were associated with greater improvements in hand grip strength (r2 = 0.95, p < 0.01), isometric knee extension (r2 = 0.88, p < 0.05), and reach score (r2 = 0.75, p < 0.05), after adjusting for changes in thigh SM volume and body weight.Conclusions: Dietary interventions that reduce IMAT, such as a VLCD, may help preserve physical function and muscle strength in older adults with obesity.Trial registration: ClinicalTrials.gov identifier: NCT02760641.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

tsRNAs Mediate Intergenerational Inheritance by Concertedly Suppressing Wnt and PPAR Pathways. tsRNAs通过共同抑制Wnt和PPAR通路介导代际遗传。

Obesity (Silver Spring, Md.) Pub Date : 2026-10-06 DOI: 10.1002/oby.70303

Jinzhao Zhou, Lijun Liu, Yanwei Zhang, Yayun Qin, Meiqi Yi, Ting Wang, Jian Hu, Jieping Song, Ling Zeng

{"title":"tsRNAs Mediate Intergenerational Inheritance by Concertedly Suppressing Wnt and PPAR Pathways.","authors":"Jinzhao Zhou, Lijun Liu, Yanwei Zhang, Yayun Qin, Meiqi Yi, Ting Wang, Jian Hu, Jieping Song, Ling Zeng","doi":"10.1002/oby.70303","DOIUrl":"https://doi.org/10.1002/oby.70303","url":null,"abstract":"Objective: The Developmental Origins of Health and Disease hypothesis posits that paternal environmental exposures program offspring metabolic health via sperm epigenetic factors, particularly tRNA-derived small RNAs (tsRNAs). Cadmium (Cd) is a ubiquitous environmental pollutant known to impair reproductive health, but epigenetic links to offspring metabolic disorders are unclear. Using paternal Cd exposure, we elucidate sperm tsRNA pathogenic mechanisms in intergenerational inheritance.Methods: We validated candidate tsRNA functions via zygotic microinjection of agomirs in mice and transfection in AML12 cells in vitro. For mechanistic insights, we conducted blastocyst low-input RNA sequencing, liver transcriptomics, and in vitro assays (luciferase, Western blot, immunofluorescence).Results: Transfection of Cd-upregulated sperm tsRNAs (tRF-Leu-CAA, tRF-Ala-AGC) inhibited PPAR signaling in AML12 cells and caused lipid disorders. In vivo, microinjection recapitulated paternal Cd effects: impaired embryogenesis and adult metabolic syndromes (weight gain, hyperlipidemia, hepatic steatosis). Mechanistically, tsRNAs suppressed Wnt and PPAR pathways from the two-cell stage, with LEF1/WNT5A as direct Wnt targets; this suppression persisted in adult liver.Conclusions: We propose a two-hit mechanism: first hit via early embryonic Wnt/PPAR co-suppression, second hit via sustained inhibition into adulthood, driving metabolic dysregulation. Thus, tsRNAs are key epigenetic vectors linking paternal Cd exposure to offspring metabolic health.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compositional Data Analysis of Relative Body Mass and Physical Function Using the Relative Shift Approach. 用相对位移法分析相对体重和身体机能的成分数据。

Obesity (Silver Spring, Md.) Pub Date : 2026-10-06 DOI: 10.1002/oby.70307

Daniel P Beavers, Lauren S Roe, Yutong Li, Katarina L Dobrosky, Ian Janssen, Kristen M Beavers

{"title":"Compositional Data Analysis of Relative Body Mass and Physical Function Using the Relative Shift Approach.","authors":"Daniel P Beavers, Lauren S Roe, Yutong Li, Katarina L Dobrosky, Ian Janssen, Kristen M Beavers","doi":"10.1002/oby.70307","DOIUrl":"https://doi.org/10.1002/oby.70307","url":null,"abstract":"Objective: The purpose of this study was to present the novel relative shift approach for compositional data analysis of body composition as a predictor for gait speed and to compare it to existing methods.Methods: Body composition was quantified from dual-energy x-ray absorptiometry in 145 older adults living with obesity. Gait speed was measured from a fast-paced 400-m walk. The associations between speed and body composition used separate least squares regression models with absolute (kg) mass and compositional methods based on isometric log-ratio (ILR) transformations and the relative shift approach.Results: All methods found significant associations between gait speed and body composition. The ILR approach was fit three times, once for each component variable (lean, fat, and bone mass). Predictions differed for the same magnitude of 5% composition change due to total body mass differences (+4.4 [0.8 to 8.0] vs. +5.0 [1.2 to 8.8] cm/s). The absolute mass model ignored the relative nature of the components. The relative shift model required no transformation and provided consistent predictions for 5% change (+4.6 [1.0 to 8.2] cm/s).Conclusions: Our data suggest the relative shift model may provide simpler estimation and interpretation than ILR for models with compositional covariates.Trial registration: ClinicalTrials.gov identifier NCT04076618.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depot-Specific Insulin Receptor Isoform Dynamics During Human Adipose-Derived Stem Cell Adipogenesis. 人脂肪来源干细胞脂肪形成过程中仓库特异性胰岛素受体异构体动力学。

Obesity (Silver Spring, Md.) Pub Date : 2026-10-01 DOI: 10.1002/oby.70315

Valentina Annamaria Genchi, Celeste Lauriola, Cristina Caccioppoli, Rossella D'Oria, Nicola Marrano, Giuseppina Biondi, Sebastio Perrini, Annalisa Natalicchio, Luigi Laviola, Francesco Giorgino, Angelo Cignarelli

{"title":"Depot-Specific Insulin Receptor Isoform Dynamics During Human Adipose-Derived Stem Cell Adipogenesis.","authors":"Valentina Annamaria Genchi, Celeste Lauriola, Cristina Caccioppoli, Rossella D'Oria, Nicola Marrano, Giuseppina Biondi, Sebastio Perrini, Annalisa Natalicchio, Luigi Laviola, Francesco Giorgino, Angelo Cignarelli","doi":"10.1002/oby.70315","DOIUrl":"https://doi.org/10.1002/oby.70315","url":null,"abstract":"Objective: The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) regulate adipose tissue (AT) differentiation. This study investigated the expression of IGF-IR, IR, and the IR isoforms (IRa and IRb) in human subcutaneous (S-ASC) and visceral (V-ASC) adipose-derived stem cells.Methods: S-AT and V-AT biopsies were obtained from human donors and ASC were differentiated into adipocytes. mRNA levels of all receptors were quantified by qPCR at baseline and after differentiation. IR protein expression and adipogenic efficiency were assessed by flow cytometry.Results: In undifferentiated ASC, IGF-IR transcripts exceeded IR and were higher in S-ASC than V-ASC. Upon differentiation, IGF-IR decreased in S-ASC but remained unchanged in V-ASC, whereas IR increased in both depots. S-ASC displayed ~twofold higher IRa expression and greater insulin-induced Akt activation. During adipogenesis, IR expression rose in both depots, with IRb exceeding IRa particularly in V-ASC (+50%). In whole AT, IR exceeded IGF-IR, and no depot-specific differences were observed between IR isoforms. Adipogenic conversion was higher in S-ASC (60%) than V-ASC (20%). Only ~77% of S-ASC- and ~61% of V-ASC-derived adipocytes expressed surface IR.Conclusions: Depot-specific dynamics of IR isoforms may influence adipogenic capacity and insulin responsiveness and suggest partially receptor-independent pathways of adipocyte differentiation.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gestational Weight Gain, Postpartum Weight Retention, and Women's Mid-Life Cardiovascular Health in Project Viva. 妊娠期体重增加、产后体重保持和妇女中年心血管健康研究

Obesity (Silver Spring, Md.) Pub Date : 2026-09-30 DOI: 10.1002/oby.70312

Benjamin Grobman, Sheryl L Rifas-Shiman, Izzuddin M Aris, Wei Perng, Sehej-Leen Parmar, Stephen P Juraschek, Emily Oken, Marie-France Hivert, Mingyu Zhang

{"title":"Gestational Weight Gain, Postpartum Weight Retention, and Women's Mid-Life Cardiovascular Health in Project Viva.","authors":"Benjamin Grobman, Sheryl L Rifas-Shiman, Izzuddin M Aris, Wei Perng, Sehej-Leen Parmar, Stephen P Juraschek, Emily Oken, Marie-France Hivert, Mingyu Zhang","doi":"10.1002/oby.70312","DOIUrl":"10.1002/oby.70312","url":null,"abstract":"Objective: This study aimed to examine associations of gestational weight gain (GWG) and postpartum weight retention (PPWR) with women's mid-life cardiovascular health.Methods: We studied 838 Project Viva participants enrolled 1999-2002 (mean age: 32.6 years). We categorized GWG as inadequate, adequate, or excessive using 2009 Institute of Medicine guidelines and calculated PPWR at 6 months, 1 year, and 2 years. At the Mid-Life Visit (2017-2021; mean age: 51.0 years), we derived Life's Essential 8 (LE8) scores (0-100; higher = better). We used linear regression models adjusted for pre-pregnancy BMI, age at enrollment, pregnancy smoking status, household income, and educational attainment.Results: Excessive versus adequate GWG was associated with worse weight status (β = -8.99, 95% CI: -12.81, -5.18) but not with the overall LE8 score (β = -1.93, 95% CI: -3.92, 0.07) or the biomedical domain score (β = -2.31, 95% CI: -5.66, 1.05). Each 1-kg higher 1-year PPWR was associated with worse biomedical domain (β = -0.49, 95% CI: -0.84, -0.14), weight status (β = -1.54, 95% CI: -1.90, -1.17), and blood pressure scores (β = -0.62, 95% CI: -1.15, -0.10). PPWR at 6 months and 2 years was also associated with worse glycemic traits scores.Conclusions: Excessive GWG was associated primarily with worse mid-life weight status, whereas higher PPWR was associated with worse mid-life cardiovascular health.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incretins, Mitochondrial Efficiency, and Muscle: Measure It Before We Model It. 肠促胰岛素，线粒体效率和肌肉：在我们建模之前测量它。

Obesity (Silver Spring, Md.) Pub Date : 2026-09-29 DOI: 10.1002/oby.70326

Lauren M Sparks, Zhen Yan

引用次数: 0

Incretin-Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency. 肠促胰岛素为基础的治疗：一个可测试的假设连接肠促胰岛素信号，线粒体氧化还原，和OXPHOS效率。

Obesity (Silver Spring, Md.) Pub Date : 2026-09-24 DOI: 10.1002/oby.70294

Bryn Falahee, Caroline M Apovian, Nawfal Istfan

{"title":"Incretin-Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency.","authors":"Bryn Falahee, Caroline M Apovian, Nawfal Istfan","doi":"10.1002/oby.70294","DOIUrl":"https://doi.org/10.1002/oby.70294","url":null,"abstract":"Objective: Incretin-based obesity therapies (IBTs), especially GLP-1 receptor agonists (GLP-1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns about IBTs' potential to uncouple oxidative phosphorylation (OXPHOS). Given the widespread use of IBTs, this inquiry is crucial due to potential adverse effects.Methods: A narrative literature review of evidence linking incretins and IBTs to mitochondrial physiology, bioenergetics, and OXPHOS was conducted.Results: Early research on incretin physiology focused on insulin secretion in pancreatic β-cells. However, GLP-1 counteracts insulin signaling during excessive nutrient delivery by activating anti-inflammatory pathways associated with fasting, suggesting it mitigates the adverse effects of overfeeding. Preclinical studies show that IBTs activate thermogenic genes and uncoupling proteins.Conclusions: We have identified indirect evidence suggesting that IBTs may induce OXPHOS uncoupling. We propose a testable hypothesis that establishes a close relationship between the distinct effects of IBTs on weight loss and their direct reduction of oxidative stress. Should this hypothesis be validated, it would enhance our comprehension of the physiology underlying IBTs and the potential adverse effects on muscle.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weight Self-Stigma and Food Noise During Post-Metabolic Bariatric Surgery Weight Stability. 体重自我污名和食物噪音在代谢减肥手术后体重稳定。

Obesity (Silver Spring, Md.) Pub Date : 2026-09-24 DOI: 10.1002/oby.70318

Dale S Bond, Yin Wu, Pavlos K Papasavas, Michael E Levin, Rebecca M Puhl, Dahlia Saad-Pendergrass, Devika Umashanker, Darren Tishler, Jason Lillis

{"title":"Weight Self-Stigma and Food Noise During Post-Metabolic Bariatric Surgery Weight Stability.","authors":"Dale S Bond, Yin Wu, Pavlos K Papasavas, Michael E Levin, Rebecca M Puhl, Dahlia Saad-Pendergrass, Devika Umashanker, Darren Tishler, Jason Lillis","doi":"10.1002/oby.70318","DOIUrl":"10.1002/oby.70318","url":null,"abstract":"Objective: Food noise has been studied with GLP-1-based therapies, but not with metabolic bariatric surgery (MBS), despite shared mechanisms. Data on food noise beyond initial weight loss are limited, and weight self-stigma (WSS), which links to poorer weight outcomes and risky behaviors after MBS, may relate to higher food noise, especially during weight stabilization. This study investigates whether WSS is associated with increased food noise during stable weight following MBS.Methods: Adults who remained weight stable following MBS completed the Weight Self-Stigma Questionnaire (WSSQ) and Food Noise Questionnaire (FNQ). Multivariable linear regression examined associations between WSSQ scores (total and self-devaluation/fear of enacted stigma subscales) and FNQ scores.Results: Participants (n = 60) were 13.3 ± 4.5 months post surgery, with a maximum weight loss of 24.8% ± 8.4%. Higher WSSQ total (B = 0.29, p = 0.001) and self-devaluation subscale (B = 0.36, p = 0.021) scores were associated with higher FNQ scores.Conclusions: Food noise increased with higher WSS, particularly among individuals reporting greater self-devaluation due to weight during postoperative weight stability. Further research should map this relationship across postoperative weight stages, test causal direction, and identify mechanisms. Because WSS and food noise can undermine health behaviors, weight loss, and health gains after MBS, routine screening and integrated clinical interventions may be warranted.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protecting CEACAM1 Expression Prevents Diet-Induced Metabolic Dysfunction and Hepatic Fibrosis in Male Mice. 保护CEACAM1表达可预防饮食诱导的雄性小鼠代谢功能障碍和肝纤维化。

Obesity (Silver Spring, Md.) Pub Date : 2026-09-23 DOI: 10.1002/oby.70302

Raziyeh Abdolahipour, Saja S Khuder, William M Philbrick, Agnes O Portuphy, Getachew D Belew, Hatem G Fallouh, Harrison T Muturi, Boyeon Kim, Jason K Kim, Sonia M Najjar

{"title":"Protecting CEACAM1 Expression Prevents Diet-Induced Metabolic Dysfunction and Hepatic Fibrosis in Male Mice.","authors":"Raziyeh Abdolahipour, Saja S Khuder, William M Philbrick, Agnes O Portuphy, Getachew D Belew, Hatem G Fallouh, Harrison T Muturi, Boyeon Kim, Jason K Kim, Sonia M Najjar","doi":"10.1002/oby.70302","DOIUrl":"https://doi.org/10.1002/oby.70302","url":null,"abstract":"Objective: High-fat diet represses Ceacam1 transcription via a PPARα-mediated mechanism to cause insulin resistance before inflammation develops. The current study investigated whether mutating PPRE-RXRα in Ceacam1 promoter prevents diet-induced metabolic abnormalities and hepatic fibrosis in male C57BL6/J mice.Methods: A knock-in mouse line (KI) bearing mutation on PPRE-RXRα in Ceacam1 promoter was generated. Male mice were fed with regular chow, high-fat diet, or GAN diet for 1-4 months before insulin action was assessed in vivo by hyperinsulinemia-euglycemia clamp analysis and energy balance was analyzed by indirect calorimetry. H&E and Sirius Red staining were carried out to detect steatohepatitis and hepatic fibrosis, respectively.Results: Feeding with high-fat or GAN diet for 1-4 months repressed hepatic CEACAM1 expression in wild-type but not KI mice. Mutating PPRE-RXRα prevented diet-induced impairment of insulin clearance to maintain normoinsulinemia and insulin sensitivity. High-fat diet failed to reduce energy expenditure and spontaneous locomotor activity in KI, as it did in wild-type mice. GAN feeding for 4 months caused mounting of a Th1-inflammatory response and hepatic fibrosis in wild-type but not KI mice.Conclusions: Blocking CEACAM1 repression while maintaining endogenous regulatory mechanisms and normal physiologic conditions sufficed to curb diet-induced metabolic dysregulation, steatosis, energy imbalance, and MASH progression.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in GLP-1 Receptor Agonist Prescribing Without an Apparent FDA-Approved Indication. GLP-1受体激动剂处方无明显fda批准适应症的趋势

Obesity (Silver Spring, Md.) Pub Date : 2026-09-22 DOI: 10.1002/oby.70301

Babak J Orandi, Leila Yan, Macey L Levan, Holly F Lofton, Karan R Chhabra, Christine J Ren-Fielding, S Ali Husain, Mara A McAdams-DeMarco, Dorry L Segev, Michal A Mankowski, Allan B Massie

{"title":"Trends in GLP-1 Receptor Agonist Prescribing Without an Apparent FDA-Approved Indication.","authors":"Babak J Orandi, Leila Yan, Macey L Levan, Holly F Lofton, Karan R Chhabra, Christine J Ren-Fielding, S Ali Husain, Mara A McAdams-DeMarco, Dorry L Segev, Michal A Mankowski, Allan B Massie","doi":"10.1002/oby.70301","DOIUrl":"https://doi.org/10.1002/oby.70301","url":null,"abstract":"Objective: This study evaluated temporal trends and patient characteristics associated with glucagon-like peptide-1 (GLP-1) receptor agonist prescribing among US adults without an apparent FDA-approved indication.Methods: This retrospective cohort study used Cosmos electronic health records (01/2021-12/2025). Adults prescribed liraglutide, semaglutide, or tirzepatide without a documented indication (type 2 diabetes or obesity with qualifying comorbidities) were included. Patients without a recorded weight ≥ 6 months prior to first prescription were excluded. Demographic and clinical characteristics were compared using t-tests and χ2 tests.Results: Among 92,415,648 adults without an apparent FDA-approved indication, 1,133,953 (1.2%) were prescribed GLP-1 receptor agonists. Prescribing increased from 0.1% in 2021 to 1.5% in 2025 (15-fold). Recipients had higher median BMI (25.9 vs. 24.5 kg/m2) and were more often female (85.5%) and White (60.0%). Hypertension and dyslipidemia were more common, while coronary artery disease and heart failure were less prevalent. Notably, 35.1% had normal BMI; eating disorders were more frequent (1.8% vs. 0.3%). GLP-1 receptor agonist use was associated with lower social vulnerability and private insurance.Conclusions: GLP-1 receptor agonist prescribing without an apparent FDA-approved indication has increased rapidly and disproportionately involves socioeconomically advantaged populations, including individuals without obesity. The risk-benefit profile in these populations remains uncertain.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0