Obesity (Silver Spring, Md.)最新文献_第2页

Utilization of antiobesity medications within the Military Health System. 军事卫生系统内抗肥胖药物的使用情况。

Obesity (Silver Spring, Md.) Pub Date : 2024-08-01 DOI: 10.1002/oby.24097

Taylor Neuman, Richele Corrado, Amanda Banaag, Tracey Perez Koehlmoos

{"title":"Utilization of antiobesity medications within the Military Health System.","authors":"Taylor Neuman, Richele Corrado, Amanda Banaag, Tracey Perez Koehlmoos","doi":"10.1002/oby.24097","DOIUrl":"https://doi.org/10.1002/oby.24097","url":null,"abstract":"Objective: The prevalence of overweight and obesity among beneficiaries of the Military Health System (MHS) is 41.6% and 30.5%, respectively. This incurs significant medical, fiscal, and military readiness costs. It is not currently known how the utilization of antiobesity medications (AOMs) within the MHS compares with that in the Veterans Health Administration or the private sector. Our aim was to assess the utilization of AOMs within the MHS.Methods: A cross-sectional study was conducted using data gathered from the MHS Data Repository and the inclusion of all adult TRICARE Prime and Plus beneficiaries ages 18 to 64 years who were prescribed at least one TRICARE-approved AOM during the years 2018 to 2022.Results: The total study population included 4,414,127 beneficiaries, of whom 1,871,780 were active-duty service members. The utilization of AOMs among the eligible population was 0.56% (0.44% among active-duty personnel). Liraglutide was the most-prescribed AOM (36% of the total). Female sex, age greater than or equal to 30 but less than 60 years, and enlisted or warrant officer rank were all associated with statistically significant higher odds of receiving AOMs.Conclusions: Comparable with the US private sector, the MHS significantly underutilizes AOMs, including among active-duty service members, despite coverage of AOMs since 2018.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fas (CD95) expression in adipocytes contributes to diet-induced obesity. 脂肪细胞中 Fas（CD95）的表达是饮食诱发肥胖的原因之一。

Obesity (Silver Spring, Md.) Pub Date : 2024-07-17 DOI: 10.1002/oby.24092

Stephan Wueest, Chiara Scaffidi, Pim P van Krieken, Nils K Konrad, Christian Koch, Michael S F Wiedemann, Anne Goergen, Marcela Borsigova, Ioannis G Lempesis, Jonas Fullin, Konstantinos N Manolopoulos, Steffen Böttcher, Gijs H Goossens, Matthias Blüher, Daniel Konrad

{"title":"Fas (CD95) expression in adipocytes contributes to diet-induced obesity.","authors":"Stephan Wueest, Chiara Scaffidi, Pim P van Krieken, Nils K Konrad, Christian Koch, Michael S F Wiedemann, Anne Goergen, Marcela Borsigova, Ioannis G Lempesis, Jonas Fullin, Konstantinos N Manolopoulos, Steffen Böttcher, Gijs H Goossens, Matthias Blüher, Daniel Konrad","doi":"10.1002/oby.24092","DOIUrl":"https://doi.org/10.1002/oby.24092","url":null,"abstract":"Objective: Induction of browning in white adipose tissue (WAT) increases energy expenditure and may be an attractive target for the treatment of obesity. Since activation of Fas (CD95) induces pathways known to blunt expression of uncoupling protein 1 (UCP1), we hypothesized that Fas expression in adipocytes inhibits WAT browning and thus contributes to the development of obesity.Methods: Adipocyte-specific Fas knockout (FasΔadipo) and control littermate (FasF/F) mice were fed a regular chow diet or a high-fat diet (HFD) for 20 weeks. Energy expenditure was assessed by indirect calorimetry, and browning was determined in subcutaneous WAT. In vitro, UCP1 was analyzed in subcutaneous murine adipocytes treated with or without Fas ligand. Moreover, FAS expression in WAT was correlated to UCP1 and percentage of body fat in human individuals.Results: HFD-fed FasΔadipo mice displayed reduced body weight gain and blunted adiposity compared to control littermates. Concomitantly, whole-body energy expenditure and WAT browning were elevated. In cultured adipocytes, Fas ligand treatment blunted isoproterenol-induced UCP1 protein levels. In support of these findings in rodents, FAS expression in WAT correlated negatively with UCP1 but positively with adiposity in human individuals.Conclusions: Fas activation in adipocytes contributes to HFD-associated adiposity in rodents and may be a therapeutic target to reduce obesity and associated diseases.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neighborhood health-promoting resources and obesity risk (the Multi-Ethnic Study of Atherosclerosis) 社区健康促进资源与肥胖风险(动脉粥样硬化多民族研究)

Obesity (Silver Spring, Md.) Pub Date : 2012-07-04 DOI: 10.1038/oby.2012.91

Amy H. Auchincloss, M. Mujahid, Mingwu Shen, E. Michos, M. Whitt-Glover, A. D. Diez Roux

引用次数: 1

Comparison of Body Adiposity Index (BAI) and Body Mass Index (BMI) with Estimations of % Body Fat in Clinically Severe Obese Women 临床重度肥胖妇女体脂指数(BAI)、体质量指数(BMI)与体脂百分比估算的比较

Obesity (Silver Spring, Md.) Pub Date : 2012-07-04 DOI: 10.1038/oby.2012.187

A. Geliebter, D. Atalayer, L. Flancbaum, C. Gibson

引用次数: 34

Family-Based Hip-Hop to Health: Outcome Results 以家庭为基础的Hip-Hop健康:结果

Obesity (Silver Spring, Md.) Pub Date : 2012-06-15 DOI: 10.1038/oby.2012.136

M. Fitzgibbon, M. Stolley, L. Schiffer, A. Kong, C. Braunschweig, S. Gomez-Perez, A. Odoms-Young, L. V. Van Horn, K. Christoffel, A. Dyer

引用次数: 3