Obesity (Silver Spring, Md.)最新文献

Placental Gene Expression Associated With Early Childhood Growth Trajectories and Obesity Risk. 胎盘基因表达与儿童早期生长轨迹和肥胖风险相关。

Obesity (Silver Spring, Md.) Pub Date : 2025-07-25 DOI: 10.1002/oby.70000

Hyo Young Choi, Luhang Han, Alison G Paquette, James MacDonald, Theo Bammler, Christine Loftus, Daniel A Enquobahrie, Kaja Z LeWinn, Nicole R Bush, Catherine J Karr, Sheela Sathyanarayana, Qi Zhao

{"title":"Placental Gene Expression Associated With Early Childhood Growth Trajectories and Obesity Risk.","authors":"Hyo Young Choi, Luhang Han, Alison G Paquette, James MacDonald, Theo Bammler, Christine Loftus, Daniel A Enquobahrie, Kaja Z LeWinn, Nicole R Bush, Catherine J Karr, Sheela Sathyanarayana, Qi Zhao","doi":"10.1002/oby.70000","DOIUrl":"https://doi.org/10.1002/oby.70000","url":null,"abstract":"Objective: This study aimed to investigate the association of placental gene expression with early childhood growth trajectories and obesity risk.Methods: We analyzed 794 children from the Conditions Affecting Neurocognitive Development and Learning in Early Childhood study. Placental samples collected at delivery underwent RNA sequencing to obtain transcriptome data. BMI trajectories from birth to 4 years (rising-high-, moderate-, and low-BMI) and overweight/obesity at 4 years were the childhood outcomes of interest. Differentially expressed genes (DEGs) associated with the outcomes were identified using DESeq2. Pathway enrichment analysis was performed on DEGs. Their causal relationships with outcomes were explored using the Mendelian randomization (MR) approach.Results: We identified 22 and 23 DEGs associated with BMI trajectories and overweight/obesity, respectively, with false discovery rates (FDR) < 0.05. Pathway analysis of these DEGs identified 26 biological pathways, primarily related to the immune system. MR analysis suggested that one (SSX2B) and eight DEGs (e.g., HSPA1A, DNAJB1) might be causally associated with the BMI trajectories and overweight/obesity (FDR < 0.05), respectively.Conclusions: This study identified placental gene expression associated with early childhood growth outcomes. These findings suggest the potential important role of placental immune system genes in the development of childhood obesity.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of unprocessed red meat on obesity and related factors: A systematic review and meta-analysis. 未加工红肉对肥胖的影响及其相关因素：系统回顾和荟萃分析。

Obesity (Silver Spring, Md.) Pub Date : 2025-07-25 DOI: 10.1002/oby.24322

Md Akheruzzaman, Marleigh Hefner, Daniel Baller, Shane Clark, Zahra Feizy, Diana M Thomas, Nikhil V Dhurandhar

{"title":"Effect of unprocessed red meat on obesity and related factors: A systematic review and meta-analysis.","authors":"Md Akheruzzaman, Marleigh Hefner, Daniel Baller, Shane Clark, Zahra Feizy, Diana M Thomas, Nikhil V Dhurandhar","doi":"10.1002/oby.24322","DOIUrl":"https://doi.org/10.1002/oby.24322","url":null,"abstract":"Objective: The objective of this study was to conduct a systematic review and meta-analysis of intervention trials that have determined the effect of unprocessed red meat (URM) intake on obesity-related outcomes.Methods: The populations, interventions, controls, and outcomes (PICO) framework was used to create questions to search seven databases from July 29, 2020, to August 21, 2020. Two reviewers independently screened 5630 references. English-language intervention trials in adults testing the effect of URM on obesity-related outcomes were included. Twenty-four studies met selection criteria. A random-effects model was developed to calculate pooled effect sizes. The DerSimonian-Laird estimator was used to estimate the variance of the true effect sizes. An interactive dashboard was published to provide transparent analysis and data presentation.Results: We found no significant effect of URM for BMI, body weight, or percent body fat based on unfiltered pooled effect sizes. Filtered pooled effect size analysis showed a slight adverse effect of URM for total cholesterol and low-density lipoprotein cholesterol.Conclusions: Studies did not show an effect of URM on weight gain, obesity, or related metabolic conditions. This may help clinicians when considering the use of URM for patients. Longer studies may be needed for observing obesity development in case the effect of URM on weight gain is small and needs a much longer time to express.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An eHealth Intervention in Pregnancy on Maternal Body Composition and Subsequent Perinatal Outcomes: A Randomized Trial. 妊娠期电子健康干预对母体身体成分和随后围产期结局的影响：一项随机试验

Obesity (Silver Spring, Md.) Pub Date : 2025-07-24 DOI: 10.1002/oby.24357

Maryam Kebbe, Kaja Falkenhain, Robbie Beyl, Abby D Altazan, Emily W Flanagan, Chelsea L Kracht, Hannah E Cabre, Emily K Woolf, Daniel S Hsia, John W Apolzan, Leanne M Redman

{"title":"An eHealth Intervention in Pregnancy on Maternal Body Composition and Subsequent Perinatal Outcomes: A Randomized Trial.","authors":"Maryam Kebbe, Kaja Falkenhain, Robbie Beyl, Abby D Altazan, Emily W Flanagan, Chelsea L Kracht, Hannah E Cabre, Emily K Woolf, Daniel S Hsia, John W Apolzan, Leanne M Redman","doi":"10.1002/oby.24357","DOIUrl":"https://doi.org/10.1002/oby.24357","url":null,"abstract":"Objective: To examine the effects of a pragmatic multicomponent eHealth intervention in pregnancy on body composition changes and subsequent associations with perinatal outcomes.Methods: Pregnant individuals (n = 351) enrolled in Louisiana's Women, Infants, and Children program were randomly assigned to a multicomponent eHealth Intervention or Usual Care. Fat percentage, fat mass, and fat-free mass were assessed using bioelectrical impedance at trimester-specific study visits. Mixed models evaluated within- and between-group differences in body composition from early to late pregnancy: overall, by BMI, and by gestational weight gain (GWG) guideline attainment. Effects of body composition changes on perinatal outcomes was evaluated.Results: Compared to Usual Care (n = 172), the Intervention Group (n = 179) had attenuated gains in fat mass, fat mass index, and fat percentage from early to late pregnancy overall, in individuals who had normal weight at enrollment, and in those who exceeded GWG guidelines (p < 0.05). No significant between-group differences in fat-free mass were observed. Fat mass change interacted with intervention effects on neonatal health outcomes (p = 0.01).Conclusions: Lifestyle interventions during pregnancy may attenuate gestational fat mass gain, particularly among women with normal weight and those who exceed GWG guidelines, with potential implications for neonatal health outcomes.Trial registration: ClinicalTrials.gov identifier: NCT04028843.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing Matters: Early Eating Mitigates Genetic Susceptibility for Obesity. 时间问题：早吃可以减轻肥胖的遗传易感性。

Obesity (Silver Spring, Md.) Pub Date : 2025-07-24 DOI: 10.1002/oby.24350

Divya Joshi, Marie Pigeyre

引用次数: 0

Risk for cancer after bariatric surgery compared with the general population: a nationwide matched cohort study. 与普通人群相比，减肥手术后患癌症的风险：一项全国性的匹配队列研究。

Obesity (Silver Spring, Md.) Pub Date : 2025-07-23 DOI: 10.1002/oby.24318

Erik Stenberg, Johan Ottosson, Yang Cao, Ida Lagstam, Erik Näslund

{"title":"Risk for cancer after bariatric surgery compared with the general population: a nationwide matched cohort study.","authors":"Erik Stenberg, Johan Ottosson, Yang Cao, Ida Lagstam, Erik Näslund","doi":"10.1002/oby.24318","DOIUrl":"https://doi.org/10.1002/oby.24318","url":null,"abstract":"Objective: Our objective was to evaluate how the incidence of cancer after metabolic and bariatric surgery (MBS) compared with the general population.Methods: A nationwide cohort of patients who underwent MBS in Sweden from 2007 to 2020 were matched (age, sex, area of residence) to controls from the general population. All patients were followed for new incidence of cancer.Results: Among the 68,424 patients who underwent MBS compared with the 640,944 controls, there was no difference in the risk for new onset of cancer (incidence rate ratio [IRR]: 1.03, 95% CI: 0.99-1.07). Compared with controls, MBS was associated with a lower risk for breast cancer in women (IRR: 0.78, 95% CI: 0.71-0.86) and nonmelanoma (IRR: 0.71, 95% CI: 0.59-0.85) and melanoma (IRR: 0.77, 95% CI: 0.68-0.87) skin cancer in men and women, but an increased risk remained for colon cancer, liver cancer, pancreatic cancer, corpus uteri cancer, renal cancer, malignant meningioma, and non-Hodgkin's lymphoma.Conclusions: All-cancer incidence risk was similar between patients who underwent MBS and the general population. Although breast and skin cancer risk was lower among MBS patients compared with controls, MBS patients had a greater risk for multiple cancer types. Thus, patients who have undergone MBS should continue recommended cancer screening and clinically approved work-up for cancer symptoms as recommended for the general population.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breastfeeding, genetic susceptibility, and type 2 diabetes in offspring in later life. 母乳喂养、遗传易感性和后代晚年2型糖尿病的关系。

Obesity (Silver Spring, Md.) Pub Date : 2025-07-23 DOI: 10.1002/oby.24344

Ying Hu, Hao Ma, Xuan Wang, Shuqi Zhu, Danqing Chen, Zhaoxia Liang

{"title":"Breastfeeding, genetic susceptibility, and type 2 diabetes in offspring in later life.","authors":"Ying Hu, Hao Ma, Xuan Wang, Shuqi Zhu, Danqing Chen, Zhaoxia Liang","doi":"10.1002/oby.24344","DOIUrl":"https://doi.org/10.1002/oby.24344","url":null,"abstract":"Objective: Our objective was to assess the prospective association between breastfeeding and the risk of type 2 diabetes (T2D) in offspring and to investigate the joint effects of breastfeeding and genetic susceptibility on T2D risk.Methods: We included 364,562 participants free from prevalent T2D from the UK Biobank. Cox proportional hazards models were employed to evaluate the association between breastfeeding and incident T2D.Results: Over a median follow-up of 12 years, 12,795 cases of incident T2D were recorded. Ever breastfeeding was associated with a significantly lower risk of T2D compared with never breastfeeding (hazard ratio = 0.94, 95% CI: 0.89-0.99). Additionally, significant interaction effects on T2D risk were observed between breastfeeding and T2D genetic risk score (T2D-GRS), both multiplicatively and additively. The association between T2D-GRS and risk of T2D was stronger in participants who were never breastfed compared with those who were breastfed (p for multiplicative interaction = 0.040). The risk of T2D associated with never breastfeeding combined with a high T2D-GRS was greater than the sum of the risks associated with each individual factor (p for additive interaction = 0.007).Conclusions: Breastfeeding is associated with a lower risk of incident T2D in offspring, showing both multiplicative and additive interactions with T2D-GRS.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Hayashi et al. 对Hayashi等人的回应。

Obesity (Silver Spring, Md.) Pub Date : 2025-07-22 DOI: 10.1002/oby.24351

Corby K Martin, Hanim E Diktas, Michelle I Cardel, Monique M LeBlanc, Stephanie L Dickinson, Erin M Ables, Xiwei Chen, Rebecca Nathan, Danielle Shapiro, Gary D Foster

引用次数: 0

Early meal timing attenuates high polygenic risk of obesity. 早进餐可以降低肥胖的多基因风险。

Obesity (Silver Spring, Md.) Pub Date : 2025-07-20 DOI: 10.1002/oby.24319

R De la Peña-Armada, María Rodríguez-Martín, Hassan S Dashti, Ana Isabel Cascales, Frank A J L Scheer, Richa Saxena, Marta Garaulet

{"title":"Early meal timing attenuates high polygenic risk of obesity.","authors":"R De la Peña-Armada, María Rodríguez-Martín, Hassan S Dashti, Ana Isabel Cascales, Frank A J L Scheer, Richa Saxena, Marta Garaulet","doi":"10.1002/oby.24319","DOIUrl":"https://doi.org/10.1002/oby.24319","url":null,"abstract":"Objective: We examined whether meal timing is associated with long-term weight-loss maintenance and whether meal timing interacts with a genome-wide polygenic score (PRS-BMI) on body weight-related outcomes. We then examined the interaction of meal timing with 97 BMI-related single-nucleotide polymorphisms on obesity outcome.Methods: Participants (N = 1195, mean age 41.07 [SD 12.68] years, female 80.8%, baseline mean BMI 31.32 [SD 5.53] kg/m2) were adults with overweight or obesity from the Obesity, Nutrigenetics, Timing, and Mediterranean (ONTIME) study. We developed a PRS-BMI to assess the genetic risk for obesity and estimated the timing of the midpoint of meal intake. We also calculated the success in long-term weight-loss maintenance after a dietary obesity treatment (at least 3 years). Linear regression analyses were performed for association and interaction assessments.Results: Each hour of delay in meal timing was associated with 2.2% higher long-term body weight (β [SE] = 2.177% [1.067%]; p = 0.042) (i.e., with lower weight-loss maintenance following dietary obesity treatment). There was a significant interaction between meal timing and PRS-BMI (p = 0.008); BMI increased by more than 2 kg/m2 for every hour of delay in meal timing in individuals with high PRS-BMI (β [SE] = 2.208 [0.502] kg/m2; p = 1.0E-5), whereas no associations were evident for those with lower genetic risk.Conclusions: Meal timing is associated with weight-loss maintenance and may influence the association between obesity genetics and BMI. Findings underscore the importance of personalized obesity management.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of GLP-1 Receptor Agonists, Dual Agonists, and Retatrutide for Weight Loss in Adults With Overweight or Obesity: A Bayesian NMA. GLP-1受体激动剂、双重激动剂和利特鲁肽对超重或肥胖成人减肥的有效性和安全性：贝叶斯NMA

Obesity (Silver Spring, Md.) Pub Date : 2025-07-20 DOI: 10.1002/oby.24360

Binayak Sinha, Samit Ghosal

{"title":"Efficacy and Safety of GLP-1 Receptor Agonists, Dual Agonists, and Retatrutide for Weight Loss in Adults With Overweight or Obesity: A Bayesian NMA.","authors":"Binayak Sinha, Samit Ghosal","doi":"10.1002/oby.24360","DOIUrl":"https://doi.org/10.1002/oby.24360","url":null,"abstract":"Objective: To compare the efficacy and safety of GLP-1 receptor agonists (GLP-1RAs), dual agonists (GLP-1RAs/GIP or GCGR), and retatrutide (GLP-1/GIP/glucagon) for weight loss in adults with overweight or obesity.Methods: We conducted a systematic review and Bayesian network meta-analysis (NMA) of 19 randomized controlled trials (RCTs) including 29,506 adults (BMI ≥ 25 kg/m2), assessing liraglutide, semaglutide, survodutide, tirzepatide, retatrutide, and placebo. Outcomes included mean weight loss, achievement of ≥ 5%, ≥ 10%, and ≥ 15% weight loss, waist circumference (WC), BMI, and adverse events (AEs) at ≥ 36 weeks. Subgroup and meta-regression analyses evaluated the impact of diabetes status, sex, age, and BMI.Results: Retatrutide and dual agonists achieved equivalent mean weight loss (-11.0 kg), surpassing GLP-1RAs (-9.0 kg), with retatrutide excelling at achieving ≥ 15% weight loss (OR 54.6). Dual agonists and GLP-1RAs followed (OR 16.4 and 9.0, respectively). Retatrutide had the highest AE risk. Meta-regression showed type 2 diabetes mellitus (T2DM) reduced weight loss by 4.338 kg for GLP-1RAs and 5.016 kg for dual agonists, with enhanced outcomes in female-dominant or high-BMI cohorts.Conclusions: Retatrutide offers superior weight loss efficacy but with a higher AE risk. Dual agonists provide a favorable efficacy-safety balance. Personalized treatment selection based on patient characteristics is recommended.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of body composition trajectories with changes in cognitive performance in the Look AHEAD study. 展望研究中身体成分轨迹与认知表现变化的关联。

Obesity (Silver Spring, Md.) Pub Date : 2025-07-20 DOI: 10.1002/oby.24212

Morgana Mongraw-Chaffin, Joni K Evans, Heather M Shappell, Mark A Espeland, Kathleen M Hayden

{"title":"Association of body composition trajectories with changes in cognitive performance in the Look AHEAD study.","authors":"Morgana Mongraw-Chaffin, Joni K Evans, Heather M Shappell, Mark A Espeland, Kathleen M Hayden","doi":"10.1002/oby.24212","DOIUrl":"https://doi.org/10.1002/oby.24212","url":null,"abstract":"Objective: The objective of this study was to investigate the longitudinal association of total body fat and appendicular lean mass (ALM), as well as sarcopenia, with cognitive decline after weight loss intervention.Methods: Among 972 Look AHEAD-MIND participants with type 2 diabetes and overweight or obesity, we investigated the longitudinal association of dual-energy x-ray absorptiometry body composition trajectories with cognitive change. We identified three latent trajectories each for total body fat and ALM. Mixed linear regression models were adjusted for the following: repeated measures; order of cognitive test; years from randomization; randomization arm; age; sex; race and ethnicity; and education. We also investigated differences in cognitive score by sarcopenia and BMI categories.Results: A gradual decrease in total body fat and no decrease in ALM were significantly independently associated with higher cognitive scores compared with other trajectories. Differences in cognitive score were large for sarcopenia, but not for obesity. Full adjustment for demographic and socioeconomic factors substantially attenuated the estimates.Conclusions: Weight loss approaches that preserve ALM and function may lead to reduced cognitive decline compared with weight loss alone. The improved ability to target interventions toward those who are more resilient to aging-related body composition changes may prevent unintended consequences of weight loss.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0