Obesity (Silver Spring, Md.)最新文献

Understanding the Increasing Prevalence of Obesity in Patients With Type 1 Diabetes: Strategies for Improving Clinical Care. 了解1型糖尿病患者肥胖症患病率的增加：改善临床护理的策略。

Obesity (Silver Spring, Md.) Pub Date : 2025-10-07 DOI: 10.1002/oby.70033

Kathleen R Ruddiman, Jessica K Bartfield, Irl B Hirsch

引用次数: 0

Long-Term Medication-Induced Weight Change Across Common Antiseizure Medications: A Target Trial Emulation Study. 常用抗癫痫药物引起的长期体重变化：一项目标试验模拟研究。

Obesity (Silver Spring, Md.) Pub Date : 2025-10-05 DOI: 10.1002/oby.24362

Han Yu, Jessica G Young, Joshua Petimar, Sheryl L Rifas-Shiman, Matthew F Daley, William J Heerman, David M Janicke, W Schuyler Jones, Takuya Kawahara, Kristina H Lewis, Pi-I D Lin, Sengwee Toh, Daniel S Weisholtz, Jason P Block

{"title":"Long-Term Medication-Induced Weight Change Across Common Antiseizure Medications: A Target Trial Emulation Study.","authors":"Han Yu, Jessica G Young, Joshua Petimar, Sheryl L Rifas-Shiman, Matthew F Daley, William J Heerman, David M Janicke, W Schuyler Jones, Takuya Kawahara, Kristina H Lewis, Pi-I D Lin, Sengwee Toh, Daniel S Weisholtz, Jason P Block","doi":"10.1002/oby.24362","DOIUrl":"https://doi.org/10.1002/oby.24362","url":null,"abstract":"Objective: To estimate long-term weight change after initiation and adherence to commonly used antiseizure medications (ASMs) and examine differences in weight change across ASMs compared to topiramate.Methods: We included 52,309 adult patients who initiated ASMs, applied a target trial emulation approach to control time-varying confounding and selection bias, and examined the long-term comparative effects on weight change after initiating and adhering to different ASMs at 6 and 12 months post initiation.Results: The most commonly initiated ASM was topiramate (41.2%). In comparison to topiramate, we estimated higher 6-month weight change under initiation and adherence to levetiracetam 0.94 kg (95% CI 0.20, 1.64), lamotrigine 1.44 kg (0.74, 1.99), valproate 2.42 kg (1.71, 2.88), carbamazepine 1.32 kg (0.46, 2.16), and oxcarbazepine 1.74 kg (0.85, 2.71), with similar results at 12 months and in sensitivity and subgroup analyses. These results were driven mostly by weight loss with use of topiramate rather than weight gain with use of other ASMs. Results were similar though attenuated when accounting for medication initiation only.Conclusions: Topiramate was associated with weight loss at 6 and 12 months under either initiation and subsequent adherence or initiation-only effects; other medications were associated with higher weight change. These results provided important information to help with decision-making regarding ASM initiation.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpreting GLP-1RA Cost-Effectiveness: A Call for Caution. 解释GLP-1RA的成本效益：谨慎的呼吁。

Obesity (Silver Spring, Md.) Pub Date : 2025-10-05 DOI: 10.1002/oby.70036

Qing Xia

引用次数: 0

Association of Longitudinal Trajectory of Body Roundness Index With CVD Risk: Evidence From a Multicohort Study. 身体圆度指数的纵向轨迹与心血管疾病风险的关联：来自多队列研究的证据。

Obesity (Silver Spring, Md.) Pub Date : 2025-10-02 DOI: 10.1002/oby.70038

Xingfang Wang, Jianhua Gu, Shuo Wu, Ping Fu, Jiqing Li

{"title":"Association of Longitudinal Trajectory of Body Roundness Index With CVD Risk: Evidence From a Multicohort Study.","authors":"Xingfang Wang, Jianhua Gu, Shuo Wu, Ping Fu, Jiqing Li","doi":"10.1002/oby.70038","DOIUrl":"https://doi.org/10.1002/oby.70038","url":null,"abstract":"Objective: This study aimed to characterize the longitudinal trajectory of the body roundness index (BRI) in a multinational cohort and to investigate its association with cardiovascular disease (CVD) events.Methods: We pooled individual-level data from three prospective cohort studies across the United States, the United Kingdom, and China, covering 2004 to 2019. The trajectory of BRI was determined using latent class growth mixed models, and the relationship between BRI trajectory and CVD risk was evaluated using Cox models.Results: Three longitudinal BRI trajectories were characterized: inverse-U (7.2%), low-increasing (44.4%), and middle-increasing (48.4%). The risk of CVD in the middle-increasing group and the inverse-U group was 1.25 times (95% CI: 1.12-1.35) and 1.86 times (1.53-2.36) higher than that in the low-increasing group, respectively. The historical maximum BRI, area under the curve, and time-weighted BRI all showed a nonlinear risk of CVD in the dose-response relationship (p < 0.05). The effect of BRI growth rate on CVD decreased with age.Conclusions: The BRI trajectories were significantly associated with CVD risk, independent of baseline BRI and BMI. This emphasizes the long-term and persistent effects of visceral fat accumulation and may provide a reference for personalized CVD risk assessment and early impact.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deviation From Genetically Predicted BMI and All-Cause Mortality: A Cohort Study in the UK Biobank. 偏离基因预测的BMI和全因死亡率：英国生物银行的一项队列研究。

Obesity (Silver Spring, Md.) Pub Date : 2025-10-02 DOI: 10.1002/oby.70042

Nuno R Zilhao, Jie Zhang, Dorret I Boomsma, Thorkild I A Sørensen, Christina C Dahm

{"title":"Deviation From Genetically Predicted BMI and All-Cause Mortality: A Cohort Study in the UK Biobank.","authors":"Nuno R Zilhao, Jie Zhang, Dorret I Boomsma, Thorkild I A Sørensen, Christina C Dahm","doi":"10.1002/oby.70042","DOIUrl":"https://doi.org/10.1002/oby.70042","url":null,"abstract":"Objective: The relation between genetically predicted BMI (gBMI) and actual BMI may have health effects. This study examines the relationship between deviations from gBMI and all-cause mortality in 208,146 UK Biobank participants.Methods: We derived gBMI from polygenic risk scores, with deviations calculated as the difference between observed and predicted BMI. Cox proportional hazards models are adjusted for confounders and current BMI.Results: Downward deviations (> 2 SD below gBMI) were associated with significantly increased mortality (HR: 1.25, 95% CI: 1.01-1.55), whereas upward deviations (> 2 SD above) showed no significant effect (HR: 1.10, 95% CI: 0.93-1.29). The mortality exhibited the known nonlinear J-shaped association with observed BMI, here lowest at BMI ~22 kg/m2, but this nadir varied by genetic predisposition; thus, for individuals with high gBMI, lowest mortality occurred at higher observed BMI (24-26 kg/m2), while those with low or medium gBMI showed sharper increases in mortality at higher BMI.Conclusions: These findings highlight the possible importance of aligning current BMI to genetic predisposition, and future research should examine BMI deviations and their long-term health effects. This perspective may inform personalized obesity management strategies to optimize health outcomes.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP) Neurons. 托吡酯增强氧源神经肽Y/ agouti相关肽（NPY/AgRP）神经元的gaba能张力。

Obesity (Silver Spring, Md.) Pub Date : 2025-10-02 DOI: 10.1002/oby.70051

Moein Minbashi Moeini, Olivier Lavoie, Alexandre Caron, Kevin W Williams, Natalie J Michael

{"title":"Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP) Neurons.","authors":"Moein Minbashi Moeini, Olivier Lavoie, Alexandre Caron, Kevin W Williams, Natalie J Michael","doi":"10.1002/oby.70051","DOIUrl":"https://doi.org/10.1002/oby.70051","url":null,"abstract":"Objective: Topiramate is a medication used off-label, or in combination with phentermine, for the management of obesity. However, its mechanism of action remains elusive. As many obesity medications target the brain, we aimed to determine if topiramate influences the activity of hypothalamic melanocortin neurons known to regulate energy balance.Methods: Transgenic mice expressing a fluorescent protein in either \"orexigenic\" neuropeptide Y/agouti-related peptide (NPY/AgRP) or \"anorexigenic\" pro-opiomelanocortin (POMC) neurons were used to perform whole-cell patch clamp electrophysiology experiments in the arcuate nucleus (ARC) of the hypothalamus.Results: Topiramate (1 μM) strongly inhibited NPY/AgRP neuron electrical excitability. Despite topiramate's well-known actions at GABAA receptors, we demonstrate that the topiramate-induced inhibition of NPY/AgRP neurons does not involve GABAA receptors. The effects of topiramate on NPY/AgRP neurons were suppressed by inhibitors of synaptic transmission and after blockade of GABAB receptors or potassium channels. In contrast, topiramate had negligible influence on the activity of POMC neurons.Conclusions: This study is the first demonstration that topiramate strongly inhibits the activity of ARC NPY/AgRP neurons and suggests that enhanced GABAergic tone to these neurons mediates this effect. The ability of topiramate to inhibit the orexigenic NPY/AgRP neurons may underlie some of its weight-lowering properties.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meeting Sleep Duration Recommendations is Associated With Lower Abdominal Adipose Tissue in 10-Year-Old Boys. 符合建议睡眠时间与10岁男孩下腹部脂肪组织有关

Obesity (Silver Spring, Md.) Pub Date : 2025-10-02 DOI: 10.1002/oby.70026

Bernard Tang, Suresh Anand Sadananthan, Delicia Shu Qin Ooi, Natarajan Padmapriya, Mya Thway Tint, Elaine Kwang-Hsia Tham, Daniel Yam Thiam Goh, Birit F P Broekman, Joshua J Gooley, Oon Hoe Teoh, Yap-Seng Chong, Peter D Gluckman, Fabian Yap, Johan G Eriksson, S Sendhil Velan, Falk Müller-Riemenschneider, Yung Seng Lee, Navin Michael, Shirong Cai

{"title":"Meeting Sleep Duration Recommendations is Associated With Lower Abdominal Adipose Tissue in 10-Year-Old Boys.","authors":"Bernard Tang, Suresh Anand Sadananthan, Delicia Shu Qin Ooi, Natarajan Padmapriya, Mya Thway Tint, Elaine Kwang-Hsia Tham, Daniel Yam Thiam Goh, Birit F P Broekman, Joshua J Gooley, Oon Hoe Teoh, Yap-Seng Chong, Peter D Gluckman, Fabian Yap, Johan G Eriksson, S Sendhil Velan, Falk Müller-Riemenschneider, Yung Seng Lee, Navin Michael, Shirong Cai","doi":"10.1002/oby.70026","DOIUrl":"https://doi.org/10.1002/oby.70026","url":null,"abstract":"Objective: This study aimed to examine sex-stratified associations between meeting recommended sleep duration and adiposity in 10-year-old children.Methods: Using the GUSTO cohort (51% boys, 10.2 ± 0.2 years), we evaluated the associations of meeting sleep duration recommendations (total daily sleep duration of ≥ 9 h, caregiver-reported and actigraphy) throughout the week with obesity and BMI z-scores (N = 638), glycoprotein acetyls (n = 436), fat mass measured by quantitative magnetic resonance (n = 528), and abdominal adipose tissue volumes measured by magnetic resonance imaging (N = 377). Multivariable linear and logistic regressions were used, adjusted for ethnicity and maternal education.Results: Boys, but not girls, whose caregiver-reported sleep duration met recommendations throughout the entire week had a lower risk of obesity (BMIz > 2.0) (OR = 0.49, 95% CI 0.27-0.87), BMIz (0.34 ± 0.16 vs. 0.98 ± 0.12) (p = 0.001), glycoprotein acetyls levels (0.65 ± 0.01 mmol/L vs. 0.70 ± 0.01 mmol/L) (p < 0.001), total fat mass (8.77 ± 0.69 kg vs. 11.31 ± 0.51 kg) (p = 0.002), and deep subcutaneous (492 ± 86 mL vs. 729 ± 56 mL) (p = 0.014), superficial subcutaneous (651 ± 85 mL vs. 888 ± 55 mL) (p = 0.013), and visceral (415 ± 51 mL vs. 557 ± 33 mL) (p = 0.013) adipose tissue volumes.Conclusions: Interventions to help children attain recommended sleep duration for weekdays and weekends may reduce abdominal and total adiposity, especially in boys.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reasons for Discontinuation of Obesity Pharmacotherapy With Semaglutide or Tirzepatide in Clinical Practice. 临床停用西马鲁肽或替西帕肽治疗肥胖的原因。

Obesity (Silver Spring, Md.) Pub Date : 2025-10-02 DOI: 10.1002/oby.70058

Hamlet Gasoyan, W Scott Butsch, Nicholas J Casacchia, Rebecca Schulte, Victoria Criswell, Jacqueline Fox, Holly Renner, Phuc Le, Jordan Alpert, Michael B Rothberg

{"title":"Reasons for Discontinuation of Obesity Pharmacotherapy With Semaglutide or Tirzepatide in Clinical Practice.","authors":"Hamlet Gasoyan, W Scott Butsch, Nicholas J Casacchia, Rebecca Schulte, Victoria Criswell, Jacqueline Fox, Holly Renner, Phuc Le, Jordan Alpert, Michael B Rothberg","doi":"10.1002/oby.70058","DOIUrl":"https://doi.org/10.1002/oby.70058","url":null,"abstract":"Objective: This study aimed to characterize the reasons for treatment discontinuation with injectable semaglutide or tirzepatide for obesity in regular clinical practice.Methods: This cross-sectional study used electronic health record data between January 2022 and December 2024 from a single integrated health system in Ohio and Florida. The primary reason for treatment discontinuation was examined in a randomly selected sample of adults with overweight or obesity and without type 2 diabetes who initiated injectable semaglutide or tirzepatide and discontinued treatment within the first year.Results: We randomly selected 288 patients; 145 received semaglutide and 143 tirzepatide. Overall, 137 patients (47.6%) discontinued their medication due to cost or insurance-related issues, 42 (14.6%) due to inability to tolerate the side effects, 34 (11.8%) as they were unable to fill the medication due to shortages, 7 (2.4%) as they switched to a compounded medication, and 5 (1.7%) due to unsatisfactory weight loss; 31 (10.8%) discontinued for other reasons, and for 32 (11.1%) patients the discontinuation reason was not specified in the electronic health record.Conclusions: High cost or insurance-related issues are the most common reasons for treatment discontinuation with semaglutide or tirzepatide for obesity. Our findings highlight the need for policies to address cost and could inform discussions between healthcare providers and patients concerning cost and side effects.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Determinants of Fatty Acid Composition in Subcutaneous and Visceral Adipose Tissue. 皮下和内脏脂肪组织中脂肪酸组成的遗传决定因素。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-29 DOI: 10.1002/oby.70045

Altayeb Ahmed, Afreen Naz, Marjola Thanaj, Elena P Sorokin, Brandon Whitcher, Jimmy D Bell, E Louise Thomas, Madeleine Cule, Hanieh Yaghootkar

{"title":"Genetic Determinants of Fatty Acid Composition in Subcutaneous and Visceral Adipose Tissue.","authors":"Altayeb Ahmed, Afreen Naz, Marjola Thanaj, Elena P Sorokin, Brandon Whitcher, Jimmy D Bell, E Louise Thomas, Madeleine Cule, Hanieh Yaghootkar","doi":"10.1002/oby.70045","DOIUrl":"https://doi.org/10.1002/oby.70045","url":null,"abstract":"Objective: Fatty acids in adipose tissue are key structural and metabolic regulators of cardiometabolic health, but the genetic architecture governing depot-specific composition in subcutaneous (SAT) and visceral adipose tissue (VAT) is not well defined.Methods: We used MRI-derived estimates of fatty acid composition in SAT and VAT from 33,583 UK Biobank participants to perform genome-wide association studies. Functional annotation, fine mapping, colocalization, and expression QTL analyses were conducted to prioritize likely causal variants and explore mechanisms.Results: We identified six loci associated with adipose tissue fatty acid composition, including both shared (PKD2L1, INSIG1) and depot-specific associations (LEKR1 and KLF14 for SAT; CDCA2 for VAT). The strongest association, rs603424-G (near PKD2L1), was linked to higher monounsaturated and polyunsaturated fatty acids, lower saturated fatty acids, and increased SCD1 expression in SAT and VAT, suggesting a role in desaturation and lipid remodeling. Several loci were linked to cardiometabolic outcomes including type 2 diabetes, hypertension, and cholelithiasis, with functional evidence supporting gene-diet interactions at the PKD2L1 locus.Conclusions: Our findings uncover genetic determinants of human adipose tissue fatty acid composition, highlight depot-specific regulation, and point to SCD1 as a potential metabolic regulator. These results deepen understanding of lipid metabolism and its links to cardiometabolic risk.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose-Dependent Insulinotropic Polypeptide and Glucagon After Weight Loss Induced by Diet or Bariatric Surgery. 饮食或减肥手术所致体重减轻后葡萄糖依赖性胰岛素性多肽和胰高血糖素的变化。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-29 DOI: 10.1002/oby.70049

Amanda Finn, Yenni Cedillo, Marthe Aukan, Barbara Gower, Catia Martins

{"title":"Glucose-Dependent Insulinotropic Polypeptide and Glucagon After Weight Loss Induced by Diet or Bariatric Surgery.","authors":"Amanda Finn, Yenni Cedillo, Marthe Aukan, Barbara Gower, Catia Martins","doi":"10.1002/oby.70049","DOIUrl":"https://doi.org/10.1002/oby.70049","url":null,"abstract":"Objective: This study compared the effects of a very low-energy diet (VLED), alone or combined with sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB), on glucose-dependent insulinotropic polypeptide (GIP) and glucagon concentrations, hormones likely to play a role in weight loss maintenance.Methods: Participants with severe obesity underwent 10 weeks of VLED alone (n = 15) or combined with SG (n = 15) or RYGB (n = 14). Plasma concentrations of glucagon and GIP (fasting and the first 60 min of a meal), insulin sensitivity, respiratory quotient, and resting energy expenditure (REE) were measured at pre- and post-intervention. Differences in hormone concentrations between groups at follow-up and associations between hormones and metabolic outcomes were evaluated.Results: Fasting glucagon concentrations were higher, while postprandial GIP concentrations were lower, after RYGB compared to SG. An increase in postprandial glucagon was associated with a decrease in Matsuda index in the RYGB group and with an increase in REE in all groups. An increase in fasting GIP was correlated with an increase in HOMA-IR.Conclusions: RYGB was associated with lower postprandial GIP and greater glucagon concentrations compared with other groups. These hormonal changes are likely to impact REE, as well as insulin sensitivity, potentially modulating the likelihood of weight loss maintenance.Trial registration: ClinicalTrials.gov identifier NCT04051190.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0