Obesity (Silver Spring, Md.)最新文献

Sex-specific white matter alterations in children exposed to high pregestational BMI. 孕前体重指数高的儿童白质改变的性别特异性。

Obesity (Silver Spring, Md.) Pub Date : 2025-04-06 DOI: 10.1002/oby.24277

Samson Nivins, Jess Reynolds, Gerald F Giesbrecht, Deborah Dewey, Nicole Letourneau, Catherine Lebel

{"title":"Sex-specific white matter alterations in children exposed to high pregestational BMI.","authors":"Samson Nivins, Jess Reynolds, Gerald F Giesbrecht, Deborah Dewey, Nicole Letourneau, Catherine Lebel","doi":"10.1002/oby.24277","DOIUrl":"https://doi.org/10.1002/oby.24277","url":null,"abstract":"Objective: This study investigated whether exposure to high pregestational BMI (≥ 25 kg/m2) is associated with alterations in white matter microstructure in early childhood, explored sex-specific effects, and examined associations with cognitive performance.Methods: A total of 90 children from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort underwent diffusion tensor imaging between ages 2 and 7 years. Data were processed using ExploreDTI to obtain mean fractional anisotropy (FA) and mean diffusivity (MD). Pregestational weight was self-reported by pregnant individuals, height was measured at enrollment, and child cognitive outcomes were assessed at ages 3 to 4 years using the Wechsler Preschool and Primary Scale of Intelligence.Results: Children exposed to high pregestational BMI had lower FA, but not higher MD, in the superior longitudinal fasciculus and in the body and splenium of the corpus callosum compared with unexposed children (BMI 18.5-24.9 kg/m2). This association persisted when analyzing pregestational obesity and overweight categories separately. Altered FA in splenium of the corpus callosum was associated with poorer cognitive outcomes in exposed children. Exposed male children had higher FA in the fornix, whereas female children had lower FA in the body and splenium of the corpus callosum compared with unexposed peers.Conclusions: High pregestational BMI was associated with alterations in white matter microstructure during early childhood in a sex-specific manner. Promoting healthy lifestyles and weight management among individuals of childbearing age is crucial.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food insecurity promotes adiposity in mice. 食物不安全会导致小鼠肥胖。

Obesity (Silver Spring, Md.) Pub Date : 2025-03-23 DOI: 10.1002/oby.24259

Cláudia R E Gil, Jens Lund, Jan J Żylicz, Pablo Ranea-Robles, Thorkild I A Sørensen, Christoffer Clemmensen

{"title":"Food insecurity promotes adiposity in mice.","authors":"Cláudia R E Gil, Jens Lund, Jan J Żylicz, Pablo Ranea-Robles, Thorkild I A Sørensen, Christoffer Clemmensen","doi":"10.1002/oby.24259","DOIUrl":"https://doi.org/10.1002/oby.24259","url":null,"abstract":"Objective: The obesity epidemic, driven by a complex interplay of environmental and biological factors, remains a significant global health challenge. Herein, we investigate the impact of food insecurity, characterized by unpredictable food access, on the regulation of body weight and body composition in mice.Methods: Male and female C57BL/6J mice were subjected to a combination of intermittent fasting and calorie restriction to simulate food insecurity.Results: Our new model demonstrates that food insecurity increases fat mass and decreases lean mass in both sexes on a standard chow diet. Additionally, high-fat diet-fed male mice exposed to the food insecurity paradigm show decreased lean mass despite being in positive energy balance. Transcriptomic analysis of white adipose tissue from food-insecure male mice revealed upregulation of metabolic pathways associated with fat mass expansion and downregulation of immune response-related transcripts.Conclusions: These findings underscore the role of food insecurity in driving metabolic adaptations that favor fat storage. Understanding this paradoxical link between food insecurity and adiposity is crucial for developing targeted interventions to address the disproportionate incidence of obesity in socioeconomically disadvantaged populations.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of lifestyle-based weight loss in older adults with obesity on muscle and bone health: a balancing act. 老年肥胖患者以生活方式为基础的减肥对肌肉和骨骼健康的影响：一种平衡行为。

Obesity (Silver Spring, Md.) Pub Date : 2025-03-10 DOI: 10.1002/oby.24229

Tiffany M Cortes, Kacey Chae, Colleen M Foy, Denise K Houston, Kristen M Beavers

{"title":"The impact of lifestyle-based weight loss in older adults with obesity on muscle and bone health: a balancing act.","authors":"Tiffany M Cortes, Kacey Chae, Colleen M Foy, Denise K Houston, Kristen M Beavers","doi":"10.1002/oby.24229","DOIUrl":"10.1002/oby.24229","url":null,"abstract":"Despite adverse metabolic and functional consequences of obesity (BMI ≥30 kg/m2), clinical recommendations for weight loss (WL) in older adults (65+ years) with obesity remain controversial. Reluctance stems partly from epidemiologic data demonstrating musculoskeletal tissue loss with WL and increased risk of disability and osteoporotic fracture. Randomized controlled trials in older adults complement and extend knowledge in this area showing: (1) lifestyle-based WL interventions often yield clinically meaningful (~8%-10%) WL in older adults; (2) lean mass loss is significant, although fat mass loss is preferential and physical performance is often improved, particularly when combined with aerobic and resistance training (RT); (3) bone loss is also significant, with some evidence that RT can attenuate WL-associated bone loss; and (4) fat mass regain after intervention cessation is common, yet physical performance gains appear to be maintained. Best practices for treating older adults with obesity include comprehensive assessment of baseline musculoskeletal health; patient-centered goal setting; moderate (i.e., -500 kcal/day) caloric restriction ensuring protein (1-1.2 g/kg/day), calcium (1000-1200 mg/day), and vitamin D (800-1000 IU/day) needs are met; incorporation of RT (≥2 days/week) and moderate-intensity weight-bearing aerobic training (≥150 min/week); and delivery of care by a multidisciplinary team.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BMI-for-age percentile curves for older adults. 老年人的bmi年龄百分位数曲线。

Obesity (Silver Spring, Md.) Pub Date : 2025-03-10 DOI: 10.1002/oby.24189

Hailey R Banack, Christopher D Kim, Claire E Cook, Alexandra Wasser, Jay S Kaufman, Steven D Stovitz

{"title":"BMI-for-age percentile curves for older adults.","authors":"Hailey R Banack, Christopher D Kim, Claire E Cook, Alexandra Wasser, Jay S Kaufman, Steven D Stovitz","doi":"10.1002/oby.24189","DOIUrl":"https://doi.org/10.1002/oby.24189","url":null,"abstract":"Objective: The objective of this manuscript is to present BMI-for-age percentile curves for men and women aged 45 to 90 years.Methods: Weighted empirical percentile estimates were calculated using data from the Canadian Longitudinal Study on Aging (CLSA) comprehensive cohort (2011-2018) according to age and sex. Statistical smoothing procedures were used to generate smoothed curves for the percentile values. Overweight and obesity were defined as BMI greater than the 85th and 95th percentile for age and sex, respectively.Results: In order to create BMI-for-age percentile curves, n = 56,705 observations were used (n = 29,961 individuals at baseline and n = 26,744 individuals at the first follow-up visit). In men, absolute values for BMI percentiles are lower than those in women, and the decline in BMI begins earlier (i.e., at a younger age). In women, the 95th percentile threshold for BMI is highest between ages 59 and 67 years (i.e., 41 kg/m2), and in men, the 95th percentile threshold for BMI is highest between ages 51 and 62 years (i.e., 39 kg/m2).Conclusions: BMI-for-age percentile curves demonstrate how an individual's BMI value compares with values from a reference population comprising individuals of the same age and sex. This approach has widespread utility to determine eligibility for interventions and as a tool to incorporate into clinical models of care for obesity management in an aging population.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Musculoskeletal characteristics in older adults with overweight or obesity: INVEST in Bone Health trial baseline analysis. 超重或肥胖老年人的肌肉骨骼特征：INVEST in Bone Health试验基线分析

Obesity (Silver Spring, Md.) Pub Date : 2025-03-06 DOI: 10.1002/oby.24243

S Delanie Lynch, Marjorie Howard, Daniel P Beavers, Leon Lenchik, Ryan Barnard, Joshua R Stapleton, Erica Lawrence, Peggy M Cawthon, Fang-Chi Hsu, Kristen M Beavers, Ashley A Weaver

{"title":"Musculoskeletal characteristics in older adults with overweight or obesity: INVEST in Bone Health trial baseline analysis.","authors":"S Delanie Lynch, Marjorie Howard, Daniel P Beavers, Leon Lenchik, Ryan Barnard, Joshua R Stapleton, Erica Lawrence, Peggy M Cawthon, Fang-Chi Hsu, Kristen M Beavers, Ashley A Weaver","doi":"10.1002/oby.24243","DOIUrl":"10.1002/oby.24243","url":null,"abstract":"Objective: The objective of this study was to examine associations of computed tomography (CT)-derived musculoskeletal measures with demographics and traditional musculoskeletal characteristics.Methods: The Incorporating Nutrition, Vests, Education, and Strength Training (INVEST) in Bone Health trial (NCT04076618) acquired a battery of musculoskeletal measures in 150 older-aged adults living with overweight or obesity. At baseline, CT (i.e., volumetric bone mineral density, cortical thickness, muscle radiomics, and muscle/intermuscular adipose tissue [IMAT] area and density), dual-energy x-ray absorptiometry (DXA; i.e., areal bone mineral density, total body fat mass, appendicular lean mass, and lean body mass), and strength assessments (i.e., grip and knee extensor strength) were collected, along with demographic and clinical characteristics. Analyses employed linear regression and mixed-effects models along with factor analysis for dimensionality reduction of the radiomics data.Results: Participants were older-aged (mean [SD] age: 66 [5] years), mostly female (75%), and were living with overweight or obesity (mean [SD] BMI: 33.6 [3.3] kg/m2). Age was not significantly associated with most CT-derived bone, IMAT, or muscle measures. BMI was significantly associated with DXA and CT-derived muscle and IMAT measures, which were higher in male than female individuals (all p < 0.01). For the midthigh, muscle size was significantly related to grip and knee extensor strength (both p < 0.01).Conclusions: Machine learning-derived CT metrics correlated strongly with DXA and muscle strength, with higher BMI linked to greater IMAT and poorer muscle quality.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does deciding not to participate in a lifestyle intervention for children with obesity affect the long-term weight change? 决定不参加生活方式干预是否会影响肥胖儿童的长期体重变化？

Obesity (Silver Spring, Md.) Pub Date : 2025-02-20 DOI: 10.1002/oby.24231

Rasmus M Jørgensen, Jane N Østergaard, Mette Fogh, Rachael W Taylor, Henrik Støvring, Jens M Bruun

{"title":"Does deciding not to participate in a lifestyle intervention for children with obesity affect the long-term weight change?","authors":"Rasmus M Jørgensen, Jane N Østergaard, Mette Fogh, Rachael W Taylor, Henrik Støvring, Jens M Bruun","doi":"10.1002/oby.24231","DOIUrl":"https://doi.org/10.1002/oby.24231","url":null,"abstract":"Objective: The objective of this study was to investigate whether long-term weight change in children with obesity is affected after deciding not to participate in a lifestyle intervention.Methods: This observational study included 713 children (aged 5-8 years) with obesity living in Aarhus, Denmark, of whom 157 decided not to participate in a community-based lifestyle intervention between 2010 and 2020, and 556 were never invited to participate (i.e., no-intervention group). Height and weight measurements were combined with socioeconomic information from national registers. A mixed-effects model with splines was used to model changes in BMI z score and stratification to investigate effect modifications.Results: We observed a median follow-up of 3.6 years (quartile [Q]1;Q3: 0.4;5.1) for the decided-not-to-participate group. No difference was observed in annual change in BMI z score between the decided-not-to-participate and no-intervention groups (0.00 per year, 95% CI: -0.03 to 0.03; p = 0.90). No effect modifications were observed between the two groups concerning highest completed household education (p = 0.59), household income (p = 0.72), or immigration status (p = 0.17).Conclusions: Children deciding not to participate in an intervention did not increase their weight compared with children who were never invited, indicating that treatment could be briefly postponed until families are able to participate. Additionally, socioeconomic status or immigration background did not modify the weight change.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of antiobesity medications for weight reduction in older adults: a systematic review. 抗肥胖药物对老年人减肥的疗效：一项系统综述。

Obesity (Silver Spring, Md.) Pub Date : 2024-12-26 DOI: 10.1002/oby.24160

Alissa S Chen, Alexandra M Hajduk, Alyssa A Grimshaw, Terri R Fried, Ania M Jastreboff, Kasia J Lipska

{"title":"Efficacy of antiobesity medications for weight reduction in older adults: a systematic review.","authors":"Alissa S Chen, Alexandra M Hajduk, Alyssa A Grimshaw, Terri R Fried, Ania M Jastreboff, Kasia J Lipska","doi":"10.1002/oby.24160","DOIUrl":"https://doi.org/10.1002/oby.24160","url":null,"abstract":"Objective: The objective of this study was to examine weight reduction and adverse events associated with use of antiobesity medications (AOMs) in older adults ages ≥65 years.Methods: Seven databases were searched for studies evaluating weight reduction of Food and Drug Administration (FDA)-approved AOMs. Studies had to include adults ages ≥65 years with obesity (BMI ≥ 30 kg/m2 or ≥27 kg/m2 with one weight-related condition), with independent analysis of weight reduction for adults ages ≥65 years. Two coauthors extracted and evaluated studies for risk of bias using standardized forms.Results: Six experimental studies (five secondary analyses of randomized clinical trial data and one single-arm trial) and two observational studies met inclusion criteria. Seven medications were studied. Sample size of older adults ranged from 13 to 6728. Experimental studies predominantly included patients with concurrent prediabetes or cardiovascular disease. All studies found statistically significant weight reduction between intervention and placebo groups or compared with baseline weight. Few studies reported on adverse events.Conclusions: Limited evidence suggests weight reduction of AOMs in older adults, with the best current evidence for the use of semaglutide in older adults with obesity and cardiovascular disease. Larger, more inclusive studies of older adults are needed to guide clinical care and determine the tolerability of AOMs for older adults.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neighborhood health-promoting resources and obesity risk (the Multi-Ethnic Study of Atherosclerosis) 社区健康促进资源与肥胖风险(动脉粥样硬化多民族研究)

Obesity (Silver Spring, Md.) Pub Date : 2012-07-04 DOI: 10.1038/oby.2012.91

Amy H. Auchincloss, M. Mujahid, Mingwu Shen, E. Michos, M. Whitt-Glover, A. D. Diez Roux

引用次数: 1

Comparison of Body Adiposity Index (BAI) and Body Mass Index (BMI) with Estimations of % Body Fat in Clinically Severe Obese Women 临床重度肥胖妇女体脂指数(BAI)、体质量指数(BMI)与体脂百分比估算的比较

Obesity (Silver Spring, Md.) Pub Date : 2012-07-04 DOI: 10.1038/oby.2012.187

A. Geliebter, D. Atalayer, L. Flancbaum, C. Gibson

引用次数: 34

Family-Based Hip-Hop to Health: Outcome Results 以家庭为基础的Hip-Hop健康:结果

Obesity (Silver Spring, Md.) Pub Date : 2012-06-15 DOI: 10.1038/oby.2012.136

M. Fitzgibbon, M. Stolley, L. Schiffer, A. Kong, C. Braunschweig, S. Gomez-Perez, A. Odoms-Young, L. V. Van Horn, K. Christoffel, A. Dyer

引用次数: 3