Obesity (Silver Spring, Md.)最新文献_第3页

Short-Term Weight Loss Outcomes of 1.0 mg Semaglutide Therapy Initiated 6 Months After Sleeve Gastrectomy. 套袖胃切除术后6个月开始1.0 mg西马鲁肽治疗的短期体重减轻结果。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-18 DOI: 10.1002/oby.70006

Mengcheng He, Yu Wang, Rong Hua, Chong Cao, Bo Xu, Qiwei Shen, Xiaojian Fu, Yikai Shao, Qiyuan Yao

{"title":"Short-Term Weight Loss Outcomes of 1.0 mg Semaglutide Therapy Initiated 6 Months After Sleeve Gastrectomy.","authors":"Mengcheng He, Yu Wang, Rong Hua, Chong Cao, Bo Xu, Qiwei Shen, Xiaojian Fu, Yikai Shao, Qiyuan Yao","doi":"10.1002/oby.70006","DOIUrl":"https://doi.org/10.1002/oby.70006","url":null,"abstract":"Objective: This study aimed to evaluate the weight loss efficacy of semaglutide initiated 6 months after laparoscopic sleeve gastrectomy (LSG).Methods: This retrospective study included patients undergoing primary LSG. Patients receiving semaglutide (1.0 mg weekly) at 6 months post LSG for 6 months were matched 1:3 with controls not receiving semaglutide, balancing demographics, preoperative BMI, waist-hip ratio, comorbidities, and total weight loss (TWL) at 6 months post surgery. Primary outcomes were absolute and percentage weight loss from 6 to 12 months post LSG.Results: Both the treatment (n = 34) and control (n = 102) groups achieved substantial TWL (23.16% ± 6.50% vs. 23.53% ± 4.87%) at 6 months post LSG. From 6 to 12 months, the treatment group experienced significantly greater absolute (14.03 ± 5.26 kg vs. 5.63 ± 6.25 kg; p < 0.0001) and percentage (12.61% ± 4.11% vs. 4.84% ± 5.18%; p < 0.0001) weight loss than controls. At 12 months, TWL was also higher in the treatment group (35.77% ± 8.35% vs. 28.37% ± 7.41%; p < 0.0001).Conclusions: Semaglutide initiated 6 months post LSG significantly enhances short-term postoperative weight loss, even among patients who have already achieved substantial initial weight loss. These findings suggest its potential as an effective adjunct therapy for optimizing weight management in early postoperative care.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality? 肥胖的精准预防、诊断和治疗：白日梦还是现实？

Obesity (Silver Spring, Md.) Pub Date : 2025-09-18 DOI: 10.1002/oby.70015

Emily K Woolf, Hanim E Diktas, Andres Acosta, John W Apolzan, Jamy D Ard, Kristen E Boyle, Jack A Gilbert, Peter T Katzmarzyk, Paul J Laurienti, Tim Lobstein, Holly L Nicastro, Jose M Ordovas, Suzanne Phelan, Leanne M Redman, Brian E Roe, Donna H Ryan, Jacqueline M Stephens, Deborah F Tate, Caroline M Apovian, Corby K Martin

{"title":"Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?","authors":"Emily K Woolf, Hanim E Diktas, Andres Acosta, John W Apolzan, Jamy D Ard, Kristen E Boyle, Jack A Gilbert, Peter T Katzmarzyk, Paul J Laurienti, Tim Lobstein, Holly L Nicastro, Jose M Ordovas, Suzanne Phelan, Leanne M Redman, Brian E Roe, Donna H Ryan, Jacqueline M Stephens, Deborah F Tate, Caroline M Apovian, Corby K Martin","doi":"10.1002/oby.70015","DOIUrl":"https://doi.org/10.1002/oby.70015","url":null,"abstract":"Precision medicine approaches have gained attention for their potential to more effectively manage obesity by tailoring diagnosis and treatment strategies to individual characteristics, including genetic background, phenotypes, metabolic profiles, and environmental exposures. The current review evaluates the evidence for precision medicine in weight management by summarizing the proceedings of a Pennington Biomedical Scientific Symposium titled \"Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?\" This review discusses the extent to which we can classify and predict obesity risk based on individual-level factors; whether we have the diagnostic capability to prospectively identify people who will benefit most from specific interventions; whether prospective trials demonstrate superior prevention and treatment of obesity when precision approaches are applied; and whether evidence is sufficient to guide policy decisions. Expert opinions were presented on the current evidence of precision medicine for obesity to collectively evaluate key barriers and opportunities for implementation of precision approaches in clinical and public health settings.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Grandmaternal Obesity and Risks of Birth Asphyxia-Related Complications in Grand-Offspring: A Countrywide Three-Generation Study. 外祖母肥胖与外孙出生窒息相关并发症的风险：一项全国三代研究

Obesity (Silver Spring, Md.) Pub Date : 2025-09-18 DOI: 10.1002/oby.70046

Eduardo Villamor, Amanda K Miglin, Sven Cnattingius

{"title":"Grandmaternal Obesity and Risks of Birth Asphyxia-Related Complications in Grand-Offspring: A Countrywide Three-Generation Study.","authors":"Eduardo Villamor, Amanda K Miglin, Sven Cnattingius","doi":"10.1002/oby.70046","DOIUrl":"https://doi.org/10.1002/oby.70046","url":null,"abstract":"Objective: We investigated the associations of grandmaternal early pregnancy BMI with grand-offspring risks of birth asphyxia-related complications.Methods: In a nationwide three-generation Swedish cohort, we estimated adjusted relative risks (RRs) of Apgar score 0-3 at 5 min and neonatal seizures for categories of grandmaternal BMI among 315,461 maternal and 203,522 paternal singleton live-born grand-offspring. To address unmeasured confounding by shared familial factors, we used the parental full sisters' BMI as a negative control exposure. In the maternal line, we assessed whether associations with grandmaternal obesity were mediated through maternal obesity.Results: Compared with normal maternal grandmaternal BMI, RRs (95% CI) of low Apgar score were, respectively, 1.29 (1.06, 1.57) and 1.53 (1.03, 2.28) for overweight (BMI 25.0 to 29.9) and obesity (BMI ≥ 30.0). For neonatal seizures, the corresponding RRs (95% CI) were 1.32 (1.05, 1.66) and 1.81 (1.17, 2.79). Maternal sisters' BMI was unrelated to both outcomes. Maternal obesity mediated < 25% of the associations with maternal grandmaternal obesity. Paternal grandmaternal obesity was related to an increased risk of neonatal seizures; paternal sisters' BMI was unrelated to this outcome.Conclusions: Grandmaternal overweight and obesity are related to increased risks of severe birth asphyxia-related complications in grand-offspring, independent of unmeasured shared familial factors.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GLP-1 Receptor Agonists and Substance Use Disorders in Older Adults With Type 2 Diabetes: A Target Trial Emulation. GLP-1受体激动剂和老年2型糖尿病患者的物质使用障碍：一项目标试验模拟

Obesity (Silver Spring, Md.) Pub Date : 2025-09-15 DOI: 10.1002/oby.70024

Hao Dai, Rotana M Radwan, Grant D Scheiffele, Huilin Tang, Amy Sheer, Hsin-Yueh Lin, Pengyue Zhang, Darlene Adirika, Kate Luong, Jiang Bian, Jingchuan Guo

{"title":"GLP-1 Receptor Agonists and Substance Use Disorders in Older Adults With Type 2 Diabetes: A Target Trial Emulation.","authors":"Hao Dai, Rotana M Radwan, Grant D Scheiffele, Huilin Tang, Amy Sheer, Hsin-Yueh Lin, Pengyue Zhang, Darlene Adirika, Kate Luong, Jiang Bian, Jingchuan Guo","doi":"10.1002/oby.70024","DOIUrl":"https://doi.org/10.1002/oby.70024","url":null,"abstract":"Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs), approved for type 2 diabetes (T2D) and obesity, may modulate reward pathways and reduce substance-related behaviors. This study assessed the association between GLP-1RA use and substance use-related hospitalization in older adults with coexisting T2D and substance use disorders (SUD).Methods: A retrospective cohort study using 2016-2020 Medicare data compared GLP-1RA initiators with new users of SGLT2 inhibitors (SGLT2is) or DPP-4 inhibitors (DPP4is) among adults aged ≥ 65. The primary outcome was hospitalization for any SUD; secondary outcomes included hospitalizations for alcohol use disorder (AUD) and opioid use disorder (OUD). Propensity score 1:1 matching and Cox proportional hazards models were used under an intention-to-treat approach.Results: In the GLP-1RA versus DPP4i cohort (n = 4920), GLP-1RA users had a lower risk of SUD hospitalization (HR 0.76; 95% CI, 0.67-0.86) and OUD hospitalization (HR 0.64; 95% CI, 0.43-0.96), with a nonsignificant trend for AUD (HR 0.76; 95% CI, 0.53-1.08). No significant differences were observed compared to SGLT2is (n = 4620).Conclusions: Among older adults with T2D, GLP-1RA use was associated with reduced SUD-related hospitalization versus DPP4i use, suggesting potential repurposing for SUD management.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Organ-Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Youth With Obesity. 探索器官特异性细胞外囊泡在肥胖青少年减肥手术后代谢改善中的作用。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-10 DOI: 10.1002/oby.70027

Ahlee Kim, Tsuyoshi Okura, Kwangmin Choi, Rupinder Gill, Vishnupriya J Borra, Kazutoshi Murakami, Andrew Poulos, Xiang Zhang, Todd Jenkins, Amy Sanghavi Shah, Michael Helmrath, Takahisa Nakamura

{"title":"Exploring Organ-Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Youth With Obesity.","authors":"Ahlee Kim, Tsuyoshi Okura, Kwangmin Choi, Rupinder Gill, Vishnupriya J Borra, Kazutoshi Murakami, Andrew Poulos, Xiang Zhang, Todd Jenkins, Amy Sanghavi Shah, Michael Helmrath, Takahisa Nakamura","doi":"10.1002/oby.70027","DOIUrl":"10.1002/oby.70027","url":null,"abstract":"Objective: Vertical sleeve gastrectomy (VSG) promotes significant metabolic improvements, though the underlying molecular mechanisms are not fully understood. Emerging evidence suggests that small extracellular vesicles (sEVs) contribute to metabolic improvements post VSG, such as improved fatty liver disease or adipose tissue function; however, it is unclear how different organ-specific sEVs interact with various metabolic parameters. The objective of this study is to establish the role of organ-specific sEVs in the metabolic improvements post VSG.Methods: Demographic and anthropometric data, metabolic parameters, and sEV samples were collected pre VSG and 3-6 months post VSG in youth with obesity. sEV RNA was sequenced for bioinformatics analyses.Results: A significant reduction of the liver-enriched mRNA cargo in sEVs was observed post VSG, whereas adipose-enriched mRNA cargo showed no such reduction. Liver-enriched mRNA cargo correlated with BMI, leptin, and resistin 6 months post VSG. Analysis of delta values (post minus pre surgery) revealed that adipose-enriched mRNA cargo correlated with markers of liver damage, whereas liver-derived mRNA cargo correlated with branched-chain amino acids.Conclusions: Following VSG, significant changes occur in the liver-enriched mRNA cargo of sEVs. Liver-derived sEVs appear to influence adipose metabolism, whereas adipose-derived sEVs are linked with liver function, suggesting dynamic intertissue cross talk that shapes systemic metabolic outcomes.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive Thermogenesis After Hypocaloric Low-Carbohydrate Versus Low-Fat Diets in African American Women: A Secondary Analysis. 非洲裔美国妇女低热量低碳水化合物与低脂肪饮食后的适应性产热：一项次要分析。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-10 DOI: 10.1002/oby.70020

Silvia Y Lopez Torres, Barbara A Gower, W Timothy Garvey, Catia Martins

{"title":"Adaptive Thermogenesis After Hypocaloric Low-Carbohydrate Versus Low-Fat Diets in African American Women: A Secondary Analysis.","authors":"Silvia Y Lopez Torres, Barbara A Gower, W Timothy Garvey, Catia Martins","doi":"10.1002/oby.70020","DOIUrl":"https://doi.org/10.1002/oby.70020","url":null,"abstract":"Objective: This secondary analysis was conducted to compare the magnitude of adaptive thermogenesis (AT) following hypocaloric low-carbohydrate (CHO) versus low-fat diets in African American (AA) women.Methods: Sixty-nine AA women with obesity were randomized to low-CHO or low-fat hypocaloric diets for 10 weeks, followed by a 4-week weight stabilization period (all food provided). At baseline and Week 13, insulin sensitivity (SI) was measured by intravenous glucose tolerance test, body composition by bioimpedance analysis, total energy expenditure (EE) (TEE) by doubly labeled water, and resting EE (REE) by indirect calorimetry.Results: Forty women finished the intervention, with an average weight loss of 6.3 ± 3.9 kg and no differences between groups. AT was present at the level of REE (-75 ± 136 kcal/day, p < 0.003, n = 38), but not TEE (-80 ± 288 kcal/day, p = 0.086, n = 40) at Week 13. Women with low SI on the low-fat diet showed greater AT at the level of TEE compared to those on the low-CHO diet (-202 ± 213 vs. 127 ± 239 kcal/day, respectively, p < 0.006).Conclusions: AA women with low SI on low-CHO diets do not experience AT, which can contribute to the superiority of this dietary approach in inducing weight and fat mass loss.Trial registration: ClinicalTrials.gov Identifier: NCT03499509 https://clinicaltrials.gov/study/NCT03499509.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward Health Equity: A Workshop Report on the State of the Science of Obesity Interventions for Adults. 迈向健康公平：关于成人肥胖干预科学现状的研讨会报告。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-10 DOI: 10.1002/oby.70035

Loneke T Blackman Carr, Jamy Ard, Carmen Byker Shanks, Evan M Forman, Stephanie P Goldstein, Debra Haire-Joshu, Ania M Jastreboff, Shaneeta Johnson, Namratha R Kandula, Peter T Katzmarzyk, Thomas C Keyserling, Shiriki K Kumanyika, Bruce Y Lee, Kristina Henderson Lewis, Michelle Y Martin, Dariush Mozaffarian, Robert L Newton, Angela Odoms-Young, Emily Panza, Nicolaas P Pronk, Lisa G Rosas, Carmen Samuel-Hodge, Laura A Schmidt, Nancy E Sherwood, Bonnie Spring, Kristen Cooksey Stowers, Monica L Baskin

{"title":"Toward Health Equity: A Workshop Report on the State of the Science of Obesity Interventions for Adults.","authors":"Loneke T Blackman Carr, Jamy Ard, Carmen Byker Shanks, Evan M Forman, Stephanie P Goldstein, Debra Haire-Joshu, Ania M Jastreboff, Shaneeta Johnson, Namratha R Kandula, Peter T Katzmarzyk, Thomas C Keyserling, Shiriki K Kumanyika, Bruce Y Lee, Kristina Henderson Lewis, Michelle Y Martin, Dariush Mozaffarian, Robert L Newton, Angela Odoms-Young, Emily Panza, Nicolaas P Pronk, Lisa G Rosas, Carmen Samuel-Hodge, Laura A Schmidt, Nancy E Sherwood, Bonnie Spring, Kristen Cooksey Stowers, Monica L Baskin","doi":"10.1002/oby.70035","DOIUrl":"https://doi.org/10.1002/oby.70035","url":null,"abstract":"Objective: From October 18-20, 2022, the National Institutes of Health held a workshop to examine the state of the science concerning obesity interventions in adults to promote health equity. The workshop had three objectives: (1) Convene experts from key institutions and the community to identify gaps in knowledge and opportunities to address obesity, (2) generate recommendations for obesity prevention and treatment to achieve health equity, and (3) identify challenges and needs to address obesity prevalence and disparities, and develop a diverse workforce.Methods: A three-day virtual convening.Results: Several key themes emerged from the workshop discussions that describe directions to build on the currently limited amount of research on obesity, disparities, and equity. Key themes centered on the determinants of health, leveraging technology, clinical, community, commercial, and policy approaches. Community-engaged work, particularly in populations that have received little focus (e.g., sexual gender minorities, Asian communities), were also discussed.Conclusions: Future research may be impactful when multilevel approaches are undertaken that leverage equity-minded tools and can be scaled up to meet community-informed population needs in a variety of settings. Funding priorities and workforce development will be critical to realizing health equity.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social and Environmental Correlates of Childhood Obesity Among Southern California Communities. 南加州社区儿童肥胖的社会和环境因素

Obesity (Silver Spring, Md.) Pub Date : 2025-09-09 DOI: 10.1002/oby.70021

Alexandra Descarpentrie, Joseph C Cleveland, Vishal Midya, Juan Espinoza, Jonatan Ottino-Gonzalez, Shana Adise, Tanya L Alderete, Michael I Goran

{"title":"Social and Environmental Correlates of Childhood Obesity Among Southern California Communities.","authors":"Alexandra Descarpentrie, Joseph C Cleveland, Vishal Midya, Juan Espinoza, Jonatan Ottino-Gonzalez, Shana Adise, Tanya L Alderete, Michael I Goran","doi":"10.1002/oby.70021","DOIUrl":"10.1002/oby.70021","url":null,"abstract":"Objective: This study aimed to identify key childhood obesity correlates in Southern California by analyzing individual components from four social determinants of health (SDoH) indices and explore their interactions.Methods: We utilized publicly available data from 330 cities across 10 counties, incorporating childhood obesity rates from the 2019 California Department of Education Physical Fitness Test (684,419 children, 40% Latino). Fifty-two individual SDoH were obtained from the Healthy Places Index, Social Vulnerability Index, CalEnviroScreen, and Child Opportunity Index (2015-2019). Weighted quantile sum regression and an interpretable machine-learning tool were used to identify which individual SDoH were significantly associated with childhood obesity.Results: We identified a SDoH mixture associated with increased percentile of childhood obesity (β [95% CI]: 10.1 [8.1, 12.1]). Fourteen factors significantly contributed, with the top six being school poverty, minority status, asthma emergency room visits, public assistance rates, hazardous waste sites, and lead exposure from housing. We also found positive associations between Latino percentage and key correlates. Cities with high school poverty and low-income housing burdens had higher obesity rates.Conclusions: This analysis moved beyond composite indices to examine specific SDoH observed alongside childhood obesity in Southern California, drawing attention to dimensions related to school, healthcare, social services, and environmental exposures.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity and Hearing Loss: Mechanisms and Future Challenges. 肥胖和听力损失：机制和未来的挑战。

Obesity (Silver Spring, Md.) Pub Date : 2025-09-07 DOI: 10.1002/oby.70016

Gonzalo Terreros H, Felipe Munoz, Amanda D'Espessailles Tapia

引用次数: 0

Tirzepatide Associated With Improved Health-Related Quality of Life in Adults With Obesity or Overweight in SURMOUNT-4. 替西帕肽与改善肥胖或超重成人健康相关生活质量相关

Obesity (Silver Spring, Md.) Pub Date : 2025-09-03 DOI: 10.1002/oby.70011

Theresa Hunter Gibble, Dachuang Cao, Madhumita Murphy, Irina Jouravskaya, Birong Liao, Harold Edward Bays

{"title":"Tirzepatide Associated With Improved Health-Related Quality of Life in Adults With Obesity or Overweight in SURMOUNT-4.","authors":"Theresa Hunter Gibble, Dachuang Cao, Madhumita Murphy, Irina Jouravskaya, Birong Liao, Harold Edward Bays","doi":"10.1002/oby.70011","DOIUrl":"https://doi.org/10.1002/oby.70011","url":null,"abstract":"Objective: In SURMOUNT-4, participants with obesity or overweight regained substantial weight after tirzepatide withdrawal, whereas continued treatment resulted in additional weight reduction. We evaluated the effect of continued tirzepatide treatment on health-related quality of life (HRQoL) in SURMOUNT-4.Methods: Participants who achieved tirzepatide maximum tolerated dose (MTD; 10 or 15 mg; N = 670) during a 36-week (W) lead-in period were randomized (1:1) to continue receiving tirzepatide MTD or switch to placebo through W88. HRQoL was assessed using patient-reported outcomes (PROs: SF-36v2, IWQOL-Lite-CT, EQ-5D-5L). Post hoc analysis included changes in PROs by weight reduction categories and baseline Patient Global Impression of Status for physical activity response categories among tirzepatide-treated participants and by weight regain categories in the placebo group.Results: Tirzepatide treatment was associated with improved PROs from W0 to W36, and these improvements were maintained from W36 to W88 with continued tirzepatide treatment versus placebo. Tirzepatide-treated participants with greater weight reduction and those with physical function limitations at baseline showed numerically greater improvements in PROs. Greater weight regain among participants who switched to placebo was associated with worsening of PROs.Conclusions: In participants with overweight or obesity, continued tirzepatide treatment was associated with maintaining HRQoL improvement, while treatment withdrawal resulted in worsening of HRQoL.Trial registration: ClinicalTrials.gov identifier NCT04660643.","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0