Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?

Obesity (Silver Spring, Md.) Pub Date : 2025-09-18 DOI:10.1002/oby.70015

Emily K Woolf, Hanim E Diktas, Andres Acosta, John W Apolzan, Jamy D Ard, Kristen E Boyle, Jack A Gilbert, Peter T Katzmarzyk, Paul J Laurienti, Tim Lobstein, Holly L Nicastro, Jose M Ordovas, Suzanne Phelan, Leanne M Redman, Brian E Roe, Donna H Ryan, Jacqueline M Stephens, Deborah F Tate, Caroline M Apovian, Corby K Martin

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Abstract

Precision medicine approaches have gained attention for their potential to more effectively manage obesity by tailoring diagnosis and treatment strategies to individual characteristics, including genetic background, phenotypes, metabolic profiles, and environmental exposures. The current review evaluates the evidence for precision medicine in weight management by summarizing the proceedings of a Pennington Biomedical Scientific Symposium titled "Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?" This review discusses the extent to which we can classify and predict obesity risk based on individual-level factors; whether we have the diagnostic capability to prospectively identify people who will benefit most from specific interventions; whether prospective trials demonstrate superior prevention and treatment of obesity when precision approaches are applied; and whether evidence is sufficient to guide policy decisions. Expert opinions were presented on the current evidence of precision medicine for obesity to collectively evaluate key barriers and opportunities for implementation of precision approaches in clinical and public health settings.

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肥胖的精准预防、诊断和治疗：白日梦还是现实？

精准医疗方法因其根据个体特征（包括遗传背景、表型、代谢谱和环境暴露）量身定制诊断和治疗策略的潜力而受到关注，从而更有效地管理肥胖。当前的综述通过总结彭宁顿生物医学科学研讨会的会议记录来评估精准医学在体重管理方面的证据，该研讨会题为“肥胖的精准预防、诊断和治疗：白日梦还是现实？”这篇综述讨论了我们在多大程度上可以根据个人水平因素对肥胖风险进行分类和预测；我们是否有诊断能力来前瞻性地确定哪些人将从特定干预措施中获益最多；前瞻性试验是否表明，当采用精确方法时，预防和治疗肥胖的效果更好；以及证据是否足以指导政策决策。针对肥胖症精准医学的现有证据提出了专家意见，以集体评估在临床和公共卫生环境中实施精准方法的主要障碍和机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Obesity (Silver Spring, Md.)

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