Joachim Holt, Rasmus Michael Sandsdal, Sarah Byberg, Charlotte Janus, Christian Rimer Juhl, Julie Rehné Jørgensen, Bolette Hartmann, Bente Stallknecht, Jens Juul Holst, Sten Madsbad, Simon Birk Kjær Jensen, Signe Sørensen Torekov
{"title":"与正常活动或GLP-1受体激动剂治疗相比，减肥后运动一年增加餐后GLP-1分泌","authors":"Joachim Holt, Rasmus Michael Sandsdal, Sarah Byberg, Charlotte Janus, Christian Rimer Juhl, Julie Rehné Jørgensen, Bolette Hartmann, Bente Stallknecht, Jens Juul Holst, Sten Madsbad, Simon Birk Kjær Jensen, Signe Sørensen Torekov","doi":"10.1002/oby.70043","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Incretin-based obesity medication maintains weight loss by mimicking the appetite-inhibiting hormone GLP-1. Interestingly, chronic exercise may improve postprandial appetite control by increasing late postprandial secretion of endogenous GLP-1. Therefore, we investigated whether an exercise program after weight loss could increase late-phase postprandial GLP-1 secretion.</p><p><strong>Methods: </strong>This study is an exploratory analysis of adults with obesity (n = 195) who lost 13.1 kg on a low-calorie diet and were randomized to 52 weeks of either usual activity, moderate-to-vigorous intensity exercise, the GLP-1 receptor agonist liraglutide (3.0 mg/day), or the combination. The primary endpoint was change in late-phase GLP-1 response to a 3-h liquid mixed meal test before and after diet-induced weight loss and after 1 year of intervention.</p><p><strong>Results: </strong>Diet-induced weight loss did not change late-phase GLP-1 response (3%; 95% CI, -4%-10%). One year of exercise increased late-phase postprandial GLP-1 response within the group by 37% (95% CI, 20%-57%), and this increase was 25% greater (95% CI, 3%-51%, p = 0.02) compared to the usual activity group. Late-phase postprandial GLP-1 response was unchanged in both groups treated with GLP-1 receptor agonist compared to placebo.</p><p><strong>Conclusions: </strong>One year of exercise increased late-phase postprandial GLP-1 response, which may prevent increased appetite after weight loss and thereby weight regain.</p><p><strong>Trial registration: </strong>EudraCT number: 2015-005585-32; ClinicalTrials.gov identifier: NCT04122716.</p>","PeriodicalId":94163,"journal":{"name":"Obesity (Silver Spring, Md.)","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"One Year of Exercise After Weight Loss Increases Postprandial GLP-1 Secretion in Contrast to Usual Activity or GLP-1 Receptor Agonist Treatment.\",\"authors\":\"Joachim Holt, Rasmus Michael Sandsdal, Sarah Byberg, Charlotte Janus, Christian Rimer Juhl, Julie Rehné Jørgensen, Bolette Hartmann, Bente Stallknecht, Jens Juul Holst, Sten Madsbad, Simon Birk Kjær Jensen, Signe Sørensen Torekov\",\"doi\":\"10.1002/oby.70043\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Incretin-based obesity medication maintains weight loss by mimicking the appetite-inhibiting hormone GLP-1. Interestingly, chronic exercise may improve postprandial appetite control by increasing late postprandial secretion of endogenous GLP-1. Therefore, we investigated whether an exercise program after weight loss could increase late-phase postprandial GLP-1 secretion.</p><p><strong>Methods: </strong>This study is an exploratory analysis of adults with obesity (n = 195) who lost 13.1 kg on a low-calorie diet and were randomized to 52 weeks of either usual activity, moderate-to-vigorous intensity exercise, the GLP-1 receptor agonist liraglutide (3.0 mg/day), or the combination. The primary endpoint was change in late-phase GLP-1 response to a 3-h liquid mixed meal test before and after diet-induced weight loss and after 1 year of intervention.</p><p><strong>Results: </strong>Diet-induced weight loss did not change late-phase GLP-1 response (3%; 95% CI, -4%-10%). One year of exercise increased late-phase postprandial GLP-1 response within the group by 37% (95% CI, 20%-57%), and this increase was 25% greater (95% CI, 3%-51%, p = 0.02) compared to the usual activity group. Late-phase postprandial GLP-1 response was unchanged in both groups treated with GLP-1 receptor agonist compared to placebo.</p><p><strong>Conclusions: </strong>One year of exercise increased late-phase postprandial GLP-1 response, which may prevent increased appetite after weight loss and thereby weight regain.</p><p><strong>Trial registration: </strong>EudraCT number: 2015-005585-32; ClinicalTrials.gov identifier: NCT04122716.</p>\",\"PeriodicalId\":94163,\"journal\":{\"name\":\"Obesity (Silver Spring, Md.)\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obesity (Silver Spring, Md.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/oby.70043\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity (Silver Spring, Md.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/oby.70043","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
One Year of Exercise After Weight Loss Increases Postprandial GLP-1 Secretion in Contrast to Usual Activity or GLP-1 Receptor Agonist Treatment.
Objective: Incretin-based obesity medication maintains weight loss by mimicking the appetite-inhibiting hormone GLP-1. Interestingly, chronic exercise may improve postprandial appetite control by increasing late postprandial secretion of endogenous GLP-1. Therefore, we investigated whether an exercise program after weight loss could increase late-phase postprandial GLP-1 secretion.
Methods: This study is an exploratory analysis of adults with obesity (n = 195) who lost 13.1 kg on a low-calorie diet and were randomized to 52 weeks of either usual activity, moderate-to-vigorous intensity exercise, the GLP-1 receptor agonist liraglutide (3.0 mg/day), or the combination. The primary endpoint was change in late-phase GLP-1 response to a 3-h liquid mixed meal test before and after diet-induced weight loss and after 1 year of intervention.
Results: Diet-induced weight loss did not change late-phase GLP-1 response (3%; 95% CI, -4%-10%). One year of exercise increased late-phase postprandial GLP-1 response within the group by 37% (95% CI, 20%-57%), and this increase was 25% greater (95% CI, 3%-51%, p = 0.02) compared to the usual activity group. Late-phase postprandial GLP-1 response was unchanged in both groups treated with GLP-1 receptor agonist compared to placebo.
Conclusions: One year of exercise increased late-phase postprandial GLP-1 response, which may prevent increased appetite after weight loss and thereby weight regain.
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