Nuklearmedizin. Nuclear medicine最新文献_第3页

The impact of the xSPECT reconstruction algorithms on the recovery coefficients value for small tumors: a phantom study with 177Lu. xSPECT重建算法对小肿瘤恢复系数值的影响：177Lu的幻影研究。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-12-11 DOI: 10.1055/a-2418-2486

Ali Ebrahimifard, Hossein Rajabi, Parham Geramifar, Markus Luster, Behrooz Hooshyar Yousefi, Robin de Nijs

{"title":"The impact of the xSPECT reconstruction algorithms on the recovery coefficients value for small tumors: a phantom study with 177Lu.","authors":"Ali Ebrahimifard, Hossein Rajabi, Parham Geramifar, Markus Luster, Behrooz Hooshyar Yousefi, Robin de Nijs","doi":"10.1055/a-2418-2486","DOIUrl":"10.1055/a-2418-2486","url":null,"abstract":"Quantifying small tumors is still a challenge due to the partial volume effect (PVE). Although iterative reconstruction had promising results with a better recovery coefficient (RC), it suffers from the PVE. RC values typically depend on the reconstruction method, which may affect on 177Lu quantifying. In this study, we investigated the effect of different reconstruction methods on RC values for 177Lu SPECT/CT images.A water-filled cylindrical polymethylmethacrylate (PMMA) phantom without background radioactivity with two solid cylinders which represent the bone and soft tissue equivalent was used for SPECT/CT imaging. We placed syringes with different volumes containing 177Lu in the vicinity of the cylinders as tumors. The iterative reconstructions of xSPECT, xSPECT Bone, and Flash3D was performed on SPECT/CT images.The effect of the reconstruction algorithms on the RC values was determined by calculating the radioactivity concentration in volumes of interest which were drawn manually and by a threshold method.The xSPECT Bone reconstruction has shown an RC value of approximately 100%, while the other reconstructions typically show an RC value of 93%. The RC values for all the reconstructions were decreased for smaller tumors. The smallest tumor showed a minimum RC between 52% and 72% compared to the largest tumor.In this study, it was possible to obtain an RC value close to 100% when the xSPECT Bone reconstruction algorithm was used. The xSPECT results were slightly lower RC values compared to the Flash3D algorithm. In using standard RC curves for tumors close to the bone, special care has to be taken since RC values relative to bone are higher than in tissue.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"132-140"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Thoracic SMARCA4-Deficient Undifferentiated Tumor on 18F-FDG PET/CT. 一例胸腔 SMARCA4 缺失型未分化肿瘤（18F-FDG PET/CT）。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-11-20 DOI: 10.1055/a-2383-2527

Gege Zhao, Zhongke Huang

引用次数: 0

Digitalization of Nuclear Medicine in Germany - Status Quo 2024. 德国核医学数字化-现状2024。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2025-04-17 DOI: 10.1055/a-2502-1728

Thomas Wendler, Julian Manuel Michael Rogasch, Moritz B Bastian, Wolfgang Burchert, Dirk Hellwig, Lena Kaiser, Philipp Lohmann, Florian Rosar, Benedikt Schemmer, Johannes Tran-Gia, Isabelle Miederer

{"title":"Digitalization of Nuclear Medicine in Germany - Status Quo 2024.","authors":"Thomas Wendler, Julian Manuel Michael Rogasch, Moritz B Bastian, Wolfgang Burchert, Dirk Hellwig, Lena Kaiser, Philipp Lohmann, Florian Rosar, Benedikt Schemmer, Johannes Tran-Gia, Isabelle Miederer","doi":"10.1055/a-2502-1728","DOIUrl":"10.1055/a-2502-1728","url":null,"abstract":"Digitalization in the healthcare sector is becoming increasingly widespread. Yet, the degree of digitalization in nuclear medicine has not been systematically investigated. The \"Digitalization and AI\" working group of the German Society of Nuclear Medicine conducted a survey to assess the status quo of digitalization of the nuclear medicine health infrastructure in Germany.100 questions were defined on eleven topics covering the main work processes in nuclear medicine. The survey primarily included single-select multiple-choice questions, yes-no questions on the availability of specific digital structures and processes, and questions assessing the degree of digitalization of certain processes and current satisfaction. The level of satisfaction was measured with an ordinal scale (1, very good to 5, poor).In most subject areas, processes relied on a combination of paper-based and electronic procedures for the topics analyzed. Differences in satisfaction regarding the different types of processes for any of the questions were not observed, and the overall level of satisfaction among responding sites was quite high.The survey did not reveal a clear need of the responding sites for complete digitalization of clinical processes. Yet, the participants highlighted the lack of proper Wi-Fi (60%) and the desire for a platform for communication between hospitals, registered doctors and patients (74%). Nevertheless, it is important to take a focused and unbiased look at the daily clinical procedures in every institution and place it in the frame of the existing tools or solutions of peer institutions to discover aspects of digitalization that can create added value in terms of time efficiency, integrity and sustainability.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"64 2","pages":"156-162"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic Neuroendocrine Tumor incidentally found on 68Ga-PSMA PET/CT. 68Ga-PSMA PET/CT偶然发现胰腺神经内分泌肿瘤。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2025-04-17 DOI: 10.1055/a-2511-6595

Rodrigo Luna, Daniel A Laheru, Eun Ji Shin, Chen Lossos, Mahalia T Robinson, Steven P Rowe, Elie Saad, Mark C Markowski

引用次数: 0

Comparison of whole-body 18F-FDG-PET/CT with 18F-FDG-PET/CT limited to skull base to upper abdomen for primary staging of lung cancer - a retrospective explorative analysis. 全身18F-FDG-PET/CT与局限于颅底至上腹的18F-FDG-PET/CT在肺癌初诊分期中的比较--一项回顾性探索分析。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-11-11 DOI: 10.1055/a-2438-7278

Lukas Schulz, Georg-Christian Funk, Klaus Kirchbacher, Elena Egger, Nino Müser, Siroos Mirzaei

{"title":"Comparison of whole-body 18F-FDG-PET/CT with 18F-FDG-PET/CT limited to skull base to upper abdomen for primary staging of lung cancer - a retrospective explorative analysis.","authors":"Lukas Schulz, Georg-Christian Funk, Klaus Kirchbacher, Elena Egger, Nino Müser, Siroos Mirzaei","doi":"10.1055/a-2438-7278","DOIUrl":"10.1055/a-2438-7278","url":null,"abstract":"The gold standard for ruling out distant metastases as part of primary staging in lung cancer is whole-body 18F-FDG-PET/CT, but this method is resource-intensive. Recent evidence suggests that examining only the thorax and upper abdomen may be sufficient 1 2 3. If a limited 18F-FDG-PET/CT approach proves effective for proper staging, it could lead to quicker examinations and reduced radiation exposure. This study aimed to determine whether limited 18F-FDG-PET/CT is adequate for the primary staging of lung cancer.In this study, a retrospective analysis of 161 patients (87 men, 74 women; age range 31-88 y) with recent or suspected lung cancer who had undergone a whole-body 18F-FDG-PET/CT examination for primary staging at our clinic between 2018 and 2022 was conducted. None of these patients showed evidence of extrathoracic metastases before the 18F-FDG-PET/CT examination. The images were divided into three regions: \"head-neck\" (HN), \"thorax-upper abdomen\" (TUA), and \"lower abdomen-hip\" (LAH). TNM staging based on the HN plus TUA region was compared with TNM staging based on the whole body.Among the 161 subjects, 7 (4%) showed malignancy-suspect lesions in HN, 110 (68%) in TUA and 7 (4%) had suspected distant metastases in LAH. The TNM staging based on HN plus TUA corresponded to TNM staging based on the whole body in 161 (100%) examinations. This finding aligns with similar results in previous literature. 18F-FDG-PET/CT limited to HN and TUA yielded accurate staging in all cases. Adopting this method could facilitate the examination and correct staging of more individuals, reducing exam waiting times and physician reporting time and minimising radiation exposure.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"150-155"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intratumoral distribution and pharmacokinetics of the radiolabeled ICAM-1 targeting monoclonal antibody R6.5 in a prostate cancer mouse model. 放射标记ICAM-1靶向单克隆抗体R6.5在前列腺癌小鼠模型中的瘤内分布和药代动力学

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI: 10.1055/a-2543-0723

Anders Örbom, Susan Evans-Axelsson, Bo Jansson, Oskar Vilhelmsson Timmermand, Thuy A Tran, Anders Bjartell, Sven-Erik Strand

{"title":"Intratumoral distribution and pharmacokinetics of the radiolabeled ICAM-1 targeting monoclonal antibody R6.5 in a prostate cancer mouse model.","authors":"Anders Örbom, Susan Evans-Axelsson, Bo Jansson, Oskar Vilhelmsson Timmermand, Thuy A Tran, Anders Bjartell, Sven-Erik Strand","doi":"10.1055/a-2543-0723","DOIUrl":"10.1055/a-2543-0723","url":null,"abstract":"Despite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.Anti-ICAM-1 antibody R6.5 was labeled with 111In or 177Lu, and a non-specific antibody with 177Lu. In vitro uptake of R6.5 was tested in PC-3 prostate cancer cells. Biodistribution studies, SPECT/CT imaging, and autoradiography were performed in a PC-3 xenograft model.In vitro uptake of R6.5 ([177Lu]Lu-R6.5) increased during 6 h of incubation. The uptake was higher at lower mAb concentration and could be blocked by 500 nM of unlabeled R6.5. In vivo and ex vivo biodistribution showed that [111In]In-R6.5 and [177Lu]Lu-R6.5 targeted the xenograft tumors better than the control Ab, however [111In]In-R6.5 had better tumor uptake than [177Lu]Lu-R6.5, probably due to less aggressive conjugation with chelator and smaller tumor sizes. From 24 h post-injection, the tumors in mice injected with [111In]In-R6.5 and [177Lu]Lu-R6.5 were visible on SPECT, optimal contrast at 48 h. Uptake was low in normal organs except the spleen and liver for all mAbs. Autoradiography showed [111In]In-R6.5 and [177Lu]Lu-R6.5 accumulated along the edges of viable tumor. The control Ab tended to accumulate in partly necrotic areas.This study demonstrates ICAM-1 as a potential target for theragnostics in CRPC.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"163-169"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A metastatic melanoma with an atypical low 18F-FDG uptake. 转移性黑色素瘤，不典型低18F-FDG摄取。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-12-04 DOI: 10.1055/a-2383-2584

Laura Ternoy, Pierre Meneret, Xavier Palard-Novello, David Russo

引用次数: 0

Comparison of 2D and 3D lung lobe quantification with Ventilation/Perfusion Ratio. 二维与三维肺叶定量与通气/灌注比的比较。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-12-04 DOI: 10.1055/a-2460-7254

Julia Katharina Vogt, Wolfgang Kurt Vogt, Alexander Heinzel, Felix M Mottaghy

{"title":"Comparison of 2D and 3D lung lobe quantification with Ventilation/Perfusion Ratio.","authors":"Julia Katharina Vogt, Wolfgang Kurt Vogt, Alexander Heinzel, Felix M Mottaghy","doi":"10.1055/a-2460-7254","DOIUrl":"10.1055/a-2460-7254","url":null,"abstract":"In this study, standard 2D lung lobe quantification is compared with two 3D lung lobe quantification software tools to investigate the clinical benefit of a 3D approach. The accuracy of 2D versus 3D lung lobe quantification is evaluated based on the calculated numerical ventilation-perfusion ratio (VQR) using a receiver operating curve (ROC) analysis.A study group of 50 consecutive patients underwent a planar lung scintigraphy (anterior/posterior) as well as ventilation/perfusion single photon emission computed tomography (SPECT/CT) to exclude acute pulmonary embolism. All data were acquired with SPECT OPTIMA NM/CT 640 (GE Healthcare). 2D analysis was performed for all ventilation/perfusion scans using a lung analysis tool (Syngo Workstation, Siemens Healthineers). 3D quantification analysis was performed using QLUNG (Q. Lung, Xeleris 4.0, GE Healthcare) and LLQ (Hermes Hybrid 3D Lung Lobar Quantification, Hermes Medical Solutions). The area under the ROC curve (AUC) served as a decision criterion to find the best agreement between clinical PE findings and calculated PE candidates of the 2D and 3D methods. The significance of the ROC curves was evaluated using the DeLong comparison.A significant difference between 2D/3D could be determined. Both 3D approaches showed robust and comparable results. The AUC range of [0.10, 0.67] was given for 2D lobar analysis, QLUNG AUC range revealed in [0.39,0.74] and LLQ AUC range was [0.42,0.72]. Averaged over all lung lobes an AUC=0.39 was given for 2D analysis and AUC=0.58 was given for LLQ/QLUNG.We could demonstrate the better performance of 3D analysis compared to 2D analysis. Consequently, is recommended to use a 3D approach in clinical practice.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"142-149"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Langerhans Cell Histiocytosis-Associated Vertebra Plana on FDG PET. FDG PET 上的朗格汉斯细胞组织细胞增生症相关椎体板块。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-11-27 DOI: 10.1055/a-2438-7469

Christopher Ruggiero, Danielle Maracaja, Steven P Rowe

引用次数: 0

Prognostic value of pretherapeutic 68Ga-PSMA-11-PET based imaging parameters in mCRPC patients treated with PSMA radioligands. 基于68Ga-PSMA-11-PET成像参数的治疗前68Ga-PSMA-11-PET对接受PSMA放射性配体治疗的mCRPC患者的预后价值。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-03-01 Epub Date: 2024-08-29 DOI: 10.1055/a-2383-2468

Laya Rahbar Nikoukar, Robert Seifert, David Ventura, Philipp Schindler, Martin Bögemann, Kambiz Rahbar, Wolfgang Roll

{"title":"Prognostic value of pretherapeutic 68Ga-PSMA-11-PET based imaging parameters in mCRPC patients treated with PSMA radioligands.","authors":"Laya Rahbar Nikoukar, Robert Seifert, David Ventura, Philipp Schindler, Martin Bögemann, Kambiz Rahbar, Wolfgang Roll","doi":"10.1055/a-2383-2468","DOIUrl":"10.1055/a-2383-2468","url":null,"abstract":"This study aims to evaluate the prognostic significance of various previously reported PSMA-PET parameters in patients undergoing 177Lu-PSMA radioligand therapy (RLT). While individual studies have investigated the prognostic value of one or few of these factors, comprehensive analyses are rare.Data of 82 patients undergoing 177Lu-PSMA-radiologand-therapy (RLT) were analyzed. Total tumor volume (tumor volume), average SUVmean of all tumor lesions (SUVmean) and the quotient of sum of SUVmean of all tumor lesions to SUVmean of the parotid glands (tumor-parotid-ratio; TPR) and of the kidneys (tumor-kidney-ratio; TKR) were included in analysis.This study showed that a tumor volume of <290.6 ml is associated with a better survival in patients undergoing PSMA-RLT (median PFS: 4.2, median OS: 13.2 months) compared to patients with higher tumor volume (median PFS: 3.4,median OS: 6.2 months; p-value = 0.01 for PFS and <0.001 for OS). The average SUVmean correlated inversely with survival. Patients with a SUVmean > 10.7 had a median PFS of 4.2 and OS of 11.4 months while patients with SUVmean <10.7 had a median PFS of 1.6 and OS of 5 months (p-value <0.001 for both). The assessment of TPR showed no significant difference regarding OS and PFS. TKR showed a better PFS in patients with ratio > 0.33 (p-value 0.009) but no significant difference regarding OS.The present study confirms that pretherapeutic PSMA-PET before RLT with 177Lu-PSMA has a prognostic value.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0