Nuklearmedizin. Nuclear medicine最新文献_第3页

The diagnostic performance of an [18F]FDG PET/CT algorithm for preoperative evaluation of extrahepatic cholangiocarcinoma: a retrospective study. [18F]FDG PET/CT算法在肝外胆管癌术前评估中的诊断价值：回顾性研究。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1055/a-2561-1179

Hui Yang, Yi Zhang, Zhiwei Guan, Can Li, Guanyun Wang, Hui Zhou, Ruimin Wang, Baixuan Xu

{"title":"The diagnostic performance of an [18F]FDG PET/CT algorithm for preoperative evaluation of extrahepatic cholangiocarcinoma: a retrospective study.","authors":"Hui Yang, Yi Zhang, Zhiwei Guan, Can Li, Guanyun Wang, Hui Zhou, Ruimin Wang, Baixuan Xu","doi":"10.1055/a-2561-1179","DOIUrl":"https://doi.org/10.1055/a-2561-1179","url":null,"abstract":"In this retrospective study, we evaluated the diagnostic value of [18F]FDG PET/CT in preoperative assessment of extrahepatic cholangiocarcinoma (ECC) and to develop a PET-based diagnostic algorithm for ECC.Patients with suspected ECC with biliary obstruction were included. Patients received [18F]FDG PET/CT scan and image analysis. FDG uptake was semi-quantified using the SUVmax of the suspected primary tumor, lymph nodes and metastatic lesions. Sex, age, tumor location, enhancement patterns and tumor size were analyzed using binary logistic regression for prediction of ECC on PET images.The study included 238 ECC patients and 42 patients with benign diseases. The lesion was located in the common bile duct in 67.50% patients and in the hilar region in 31.79% patients. [18F]FDG PET/CT scan showed a sensitivity of 70.6% and a specificity of 76.2% for the diagnosis of cholangiocarcinoma in patients with extrahepatic lesions, with a positive predictive value of 94.4% and a negative predictive value of 31.4% and an accuracy of 71.4%. Forced entry logistic regression analysis showed that age (OR 1.07, 95%CI, 1.03 to 1.10) and detection of ECC by [18F]FDG PET/CT scan (OR 6.15, 95% CI, 2.00 to 19.10) were predictors of ECC. A PET-based scoring algorithm had an AUC of 0.81 (95% CI, 0.75 to 0.88) and had a sensitivity of 61.3% and a specificity of 88.1% for ECC. The algorithm had a significantly better diagnostic performance than [18F]FDG PET/CT scan (Chi square test, P <0.001).The PET-based algorithm shows improved diagnostic performance for the detection of ECC and could facilitate early diagnosis and staging of ECC.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"64 3","pages":"205-214"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Importance of oxyphil cells for 99mTc-sestamibi uptake in primary hyperparathyroidism: a retrospective observational study. 原发性甲状旁腺功能亢进症患者嗜氧细胞对99m锝-sestamibi摄取的重要性：一项回顾性观察研究。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2025-03-06 DOI: 10.1055/a-2535-1067

Jan Axl Dropmann, Axel Kleespies, Heinrich Fuerst, Marcus Kremer, Moritz Drefs, Michael Neuberger

{"title":"Importance of oxyphil cells for 99mTc-sestamibi uptake in primary hyperparathyroidism: a retrospective observational study.","authors":"Jan Axl Dropmann, Axel Kleespies, Heinrich Fuerst, Marcus Kremer, Moritz Drefs, Michael Neuberger","doi":"10.1055/a-2535-1067","DOIUrl":"10.1055/a-2535-1067","url":null,"abstract":"In patients with primary hyperparathyroidism (pHPT), the importance of oxyphil cells for 99mTc-sestamibi uptake is uncertain.This retrospective observational study of pHPT patients evaluated independent associations between oxyphil cell content (OCC) and preoperative scintigraphic (SC) findings, using logistic regression analyses.We studied 76 patients with pHPT before and after operation. Preoperative SC was able to definitively identify abnormal parathyroid tissue in 47 patients (61.8%). The median relative OCC (postoperative histopathological examination) was 10% (IQR 0.25% - 40%) and the median absolute OCC was 0.09 cm3 (IQR 0.00 - 0.59 cm3). After adjustment for confounders, an iPTH concentration >200 pg/ml and increasing OCC was the only significant independent predictor of a definitively positive SC result (per category of relative OCC: adjusted odds ratio (aOR) 2.40, 95% confidence interval (CI) 1.02 - 5.65, p=0.045).In patients with pHPT, a higher OCC was associated with a significantly higher probability of a clearly positive SC finding.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"215-224"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Male Breast Cancer Detected by Myocardial Perfusion Scintigraphy. 心肌灌注显像检测男性乳腺癌1例。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2025-03-12 DOI: 10.1055/a-2543-0846

Ahmet Eren Şen, Fatma Hicret Tekin, Mustafa Erol, Ülkünur Çimen Şen

引用次数: 0

Successful Theranostic Application of Somatostatin Receptor Peptides in a Rare Case of Familial Multicentric Paragangliomas. 生长抑素受体肽在罕见家族性多中心副神经节瘤中的成功应用。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1055/a-2561-1380

Akram Al-Ibraheem, Hasan Alalawi, Ula Al-Rasheed, Abeer Anabtawi, Ahmed Saad Abdlkadir

引用次数: 0

The impact of the xSPECT reconstruction algorithms on the recovery coefficients value for small tumors: a phantom study with 177Lu. xSPECT重建算法对小肿瘤恢复系数值的影响：177Lu的幻影研究。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-12-11 DOI: 10.1055/a-2418-2486

Ali Ebrahimifard, Hossein Rajabi, Parham Geramifar, Markus Luster, Behrooz Hooshyar Yousefi, Robin de Nijs

{"title":"The impact of the xSPECT reconstruction algorithms on the recovery coefficients value for small tumors: a phantom study with 177Lu.","authors":"Ali Ebrahimifard, Hossein Rajabi, Parham Geramifar, Markus Luster, Behrooz Hooshyar Yousefi, Robin de Nijs","doi":"10.1055/a-2418-2486","DOIUrl":"10.1055/a-2418-2486","url":null,"abstract":"Quantifying small tumors is still a challenge due to the partial volume effect (PVE). Although iterative reconstruction had promising results with a better recovery coefficient (RC), it suffers from the PVE. RC values typically depend on the reconstruction method, which may affect on 177Lu quantifying. In this study, we investigated the effect of different reconstruction methods on RC values for 177Lu SPECT/CT images.A water-filled cylindrical polymethylmethacrylate (PMMA) phantom without background radioactivity with two solid cylinders which represent the bone and soft tissue equivalent was used for SPECT/CT imaging. We placed syringes with different volumes containing 177Lu in the vicinity of the cylinders as tumors. The iterative reconstructions of xSPECT, xSPECT Bone, and Flash3D was performed on SPECT/CT images.The effect of the reconstruction algorithms on the RC values was determined by calculating the radioactivity concentration in volumes of interest which were drawn manually and by a threshold method.The xSPECT Bone reconstruction has shown an RC value of approximately 100%, while the other reconstructions typically show an RC value of 93%. The RC values for all the reconstructions were decreased for smaller tumors. The smallest tumor showed a minimum RC between 52% and 72% compared to the largest tumor.In this study, it was possible to obtain an RC value close to 100% when the xSPECT Bone reconstruction algorithm was used. The xSPECT results were slightly lower RC values compared to the Flash3D algorithm. In using standard RC curves for tumors close to the bone, special care has to be taken since RC values relative to bone are higher than in tissue.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"132-140"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Thoracic SMARCA4-Deficient Undifferentiated Tumor on 18F-FDG PET/CT. 一例胸腔 SMARCA4 缺失型未分化肿瘤（18F-FDG PET/CT）。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-11-20 DOI: 10.1055/a-2383-2527

Gege Zhao, Zhongke Huang

引用次数: 0

Digitalization of Nuclear Medicine in Germany - Status Quo 2024. 德国核医学数字化-现状2024。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2025-04-17 DOI: 10.1055/a-2502-1728

Thomas Wendler, Julian Manuel Michael Rogasch, Moritz B Bastian, Wolfgang Burchert, Dirk Hellwig, Lena Kaiser, Philipp Lohmann, Florian Rosar, Benedikt Schemmer, Johannes Tran-Gia, Isabelle Miederer

{"title":"Digitalization of Nuclear Medicine in Germany - Status Quo 2024.","authors":"Thomas Wendler, Julian Manuel Michael Rogasch, Moritz B Bastian, Wolfgang Burchert, Dirk Hellwig, Lena Kaiser, Philipp Lohmann, Florian Rosar, Benedikt Schemmer, Johannes Tran-Gia, Isabelle Miederer","doi":"10.1055/a-2502-1728","DOIUrl":"10.1055/a-2502-1728","url":null,"abstract":"Digitalization in the healthcare sector is becoming increasingly widespread. Yet, the degree of digitalization in nuclear medicine has not been systematically investigated. The \"Digitalization and AI\" working group of the German Society of Nuclear Medicine conducted a survey to assess the status quo of digitalization of the nuclear medicine health infrastructure in Germany.100 questions were defined on eleven topics covering the main work processes in nuclear medicine. The survey primarily included single-select multiple-choice questions, yes-no questions on the availability of specific digital structures and processes, and questions assessing the degree of digitalization of certain processes and current satisfaction. The level of satisfaction was measured with an ordinal scale (1, very good to 5, poor).In most subject areas, processes relied on a combination of paper-based and electronic procedures for the topics analyzed. Differences in satisfaction regarding the different types of processes for any of the questions were not observed, and the overall level of satisfaction among responding sites was quite high.The survey did not reveal a clear need of the responding sites for complete digitalization of clinical processes. Yet, the participants highlighted the lack of proper Wi-Fi (60%) and the desire for a platform for communication between hospitals, registered doctors and patients (74%). Nevertheless, it is important to take a focused and unbiased look at the daily clinical procedures in every institution and place it in the frame of the existing tools or solutions of peer institutions to discover aspects of digitalization that can create added value in terms of time efficiency, integrity and sustainability.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"64 2","pages":"156-162"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic Neuroendocrine Tumor incidentally found on 68Ga-PSMA PET/CT. 68Ga-PSMA PET/CT偶然发现胰腺神经内分泌肿瘤。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2025-04-17 DOI: 10.1055/a-2511-6595

Rodrigo Luna, Daniel A Laheru, Eun Ji Shin, Chen Lossos, Mahalia T Robinson, Steven P Rowe, Elie Saad, Mark C Markowski

引用次数: 0

Comparison of whole-body 18F-FDG-PET/CT with 18F-FDG-PET/CT limited to skull base to upper abdomen for primary staging of lung cancer - a retrospective explorative analysis. 全身18F-FDG-PET/CT与局限于颅底至上腹的18F-FDG-PET/CT在肺癌初诊分期中的比较--一项回顾性探索分析。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-11-11 DOI: 10.1055/a-2438-7278

Lukas Schulz, Georg-Christian Funk, Klaus Kirchbacher, Elena Egger, Nino Müser, Siroos Mirzaei

{"title":"Comparison of whole-body 18F-FDG-PET/CT with 18F-FDG-PET/CT limited to skull base to upper abdomen for primary staging of lung cancer - a retrospective explorative analysis.","authors":"Lukas Schulz, Georg-Christian Funk, Klaus Kirchbacher, Elena Egger, Nino Müser, Siroos Mirzaei","doi":"10.1055/a-2438-7278","DOIUrl":"10.1055/a-2438-7278","url":null,"abstract":"The gold standard for ruling out distant metastases as part of primary staging in lung cancer is whole-body 18F-FDG-PET/CT, but this method is resource-intensive. Recent evidence suggests that examining only the thorax and upper abdomen may be sufficient 1 2 3. If a limited 18F-FDG-PET/CT approach proves effective for proper staging, it could lead to quicker examinations and reduced radiation exposure. This study aimed to determine whether limited 18F-FDG-PET/CT is adequate for the primary staging of lung cancer.In this study, a retrospective analysis of 161 patients (87 men, 74 women; age range 31-88 y) with recent or suspected lung cancer who had undergone a whole-body 18F-FDG-PET/CT examination for primary staging at our clinic between 2018 and 2022 was conducted. None of these patients showed evidence of extrathoracic metastases before the 18F-FDG-PET/CT examination. The images were divided into three regions: \"head-neck\" (HN), \"thorax-upper abdomen\" (TUA), and \"lower abdomen-hip\" (LAH). TNM staging based on the HN plus TUA region was compared with TNM staging based on the whole body.Among the 161 subjects, 7 (4%) showed malignancy-suspect lesions in HN, 110 (68%) in TUA and 7 (4%) had suspected distant metastases in LAH. The TNM staging based on HN plus TUA corresponded to TNM staging based on the whole body in 161 (100%) examinations. This finding aligns with similar results in previous literature. 18F-FDG-PET/CT limited to HN and TUA yielded accurate staging in all cases. Adopting this method could facilitate the examination and correct staging of more individuals, reducing exam waiting times and physician reporting time and minimising radiation exposure.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"150-155"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A metastatic melanoma with an atypical low 18F-FDG uptake. 转移性黑色素瘤，不典型低18F-FDG摄取。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-12-04 DOI: 10.1055/a-2383-2584

Laura Ternoy, Pierre Meneret, Xavier Palard-Novello, David Russo

引用次数: 0