Nuklearmedizin. Nuclear medicine最新文献_第4页

Diagnostic accuracy of artificial intelligence-enabled vectorcardiography versus myocardial perfusion SPECT in patients with suspected or known coronary heart disease. 人工智能矢量心电图与心肌灌注 SPECT 对疑似或已知冠心病患者的诊断准确性对比。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-06-01 Epub Date: 2024-02-20 DOI: 10.1055/a-2263-2322

Simon Aydar, Hermann Knobl, Wolfgang Burchert, Oliver Lindner

{"title":"Diagnostic accuracy of artificial intelligence-enabled vectorcardiography versus myocardial perfusion SPECT in patients with suspected or known coronary heart disease.","authors":"Simon Aydar, Hermann Knobl, Wolfgang Burchert, Oliver Lindner","doi":"10.1055/a-2263-2322","DOIUrl":"10.1055/a-2263-2322","url":null,"abstract":"Aim: The present study evaluated with myocardial perfusion SPECT (MPS) the diagnostic accuracy of an artificial intelligence-enabled vectorcardiography system (Cardisiography, CSG) for detection of perfusion abnormalities.Methods: We studied 241 patients, 155 with suspected CAD and 86 with known CAD who were referred for MPS. The CSG was performed after the MPS acquisition. The CSG results (1) p-factor (perfusion, 0: normal, 1: mildly, 2: moderately, 3: highly abnormal) and (2) s-factor (structure, categories as p-factor) were compared with the MPS scores. The CSG system was not trained during the study.Results: Considering the p-factor alone, a specificity of >78% and a negative predictive value of mostly >90% for all MPS variables were found. The sensitivities ranged from 17 to 56%, the positive predictive values from 4 to 38%. Combining the p- and the s-factor, significantly higher specificity values of about 90% were reached. The s-factor showed a significant correlation (p=0.006) with the MPS ejection fraction.Conclusions: The CSG system is able to exclude relevant perfusion abnormalities in patients with suspected or known CAD with a specificity and a negative predictive value of about 90% combining the p- and the s-factor. Since it is a learning system there is potential for further improvement before routine use.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"213-218"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139914369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Radioiodine Treatment on Quality of Life in Patients with Subclinical Hyperthyroidism: A Prospective Controlled Study. 放射性碘治疗对亚临床甲亢患者生活质量的影响：前瞻性对照研究

Nuklearmedizin. Nuclear medicine Pub Date : 2024-06-01 Epub Date: 2024-01-23 DOI: 10.1055/a-2240-8087

Rolf Larisch, John E M Midgley, Johannes W Dietrich, Rudolf Hoermann

{"title":"Effect of Radioiodine Treatment on Quality of Life in Patients with Subclinical Hyperthyroidism: A Prospective Controlled Study.","authors":"Rolf Larisch, John E M Midgley, Johannes W Dietrich, Rudolf Hoermann","doi":"10.1055/a-2240-8087","DOIUrl":"10.1055/a-2240-8087","url":null,"abstract":"Radioiodine treatment (RIT) has a high success rate in both the treatment of hyperthyroidism and improving the quality of life (QoL) of symptomatic patients. In asymptomatic patients with subclinical hyperthyroidism thyroid related QoL outcomes are less well known.Methods: Study aim was to evaluate thyroid-related QoL in patients with subclinical hyperthyroidism mostly due to toxic nodular goitre undergoing RIT, compared to a control group of euthyroid subjects. Study design was monocentric, prospective, controlled. Fifty control subjects were enrolled and 51 RIT patients. Most subjects were examined at least twice at an interval of 6 months, with visits immediately before and 6 months after treatment in the RIT group. QoL was estimated with the ThyPRO questionnaire, using its composite scale as primary outcome. Treatment effect was the mean adjusted difference (MAD) between groups over time, using repeated? measures mixed? effects models.Results: TSH concentrations were lower in the RIT group prior to treatment and recovered thereafter slightly above the level of the control group. Correspondingly, QoL improved significantly after 6 months from a worse level in the RIT group, compared to controls (MAD -10.3 [95% CI -14.9, -5.7], p<0.001). QoL improvements were strong for general items, but less pronounced for the hyperthyroid domain. Compared to controls, thyroid volume, thyroid functional capacity (SPINA-GT) and deiodinase activity (SPINA-GD) were significantly reduced in the RIT group.Conclusion: Patients with subclinical hyperthyroidism improve both biochemically and in their QoL after RIT, compared to controls. QoL assessment should have a wider role in clinical practice to complement biochemical tests and help with treatment decisions.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"176-187"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139543858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: 99mTc-MDP Bone Scan and 18F-FDG PET/CT Imaging of Primary Hepatic Osteosarcoma. 更正：原发性肝骨肉瘤的 99mTc-MDP 骨扫描和 18F-FDG PET/CT 成像。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-06-01 Epub Date: 2024-03-04 DOI: 10.1055/a-2275-1035

Yao Liu, Wen Tang, Zhongke Huang

引用次数: 0

Dosimetry in a patient with peritoneal dialysis treated with [177Lu]Lu-PSMA-617. 用[177Lu]Lu-PSMA-617治疗一名腹膜透析患者的剂量测定。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-06-01 Epub Date: 2024-01-08 DOI: 10.1055/a-2224-9536

Kathrin Glass, Andreas Hendrik Hering, Alexander Heinzel

引用次数: 0

Peculiar Pattern of Response Following [225Ac]Ac-PSMA Therapy: A Case Report with 'PSA Pseudoregression' Response Pattern. 225Ac]Ac-PSMA治疗后的奇特反应模式：PSA 伪回归 "反应模式的病例报告。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-05-17 DOI: 10.1055/a-2311-5679

Akram Al-Ibraheem, Feras Istatieh, A. Abdlkadir, Alaa’ Abufara, Baha’ Sharaf, R. Abu-Hijlih, NabeelaQublan Al-Hajaj, S. Salah

引用次数: 0

Computational Decision Support for PE Diagnosis based on Ventilation Perfusion Ratio. 基于通气灌注比的 PE 诊断计算决策支持。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-04-09 DOI: 10.1055/a-2287-2051

Julia Katharina Vogt, Wolfgang Kurt Vogt, Alexander Heinzel, F. Mottaghy

{"title":"Computational Decision Support for PE Diagnosis based on Ventilation Perfusion Ratio.","authors":"Julia Katharina Vogt, Wolfgang Kurt Vogt, Alexander Heinzel, F. Mottaghy","doi":"10.1055/a-2287-2051","DOIUrl":"https://doi.org/10.1055/a-2287-2051","url":null,"abstract":"AIM\u0000The aim of this study is to investigate whether computer-aided, semi-automated 3D lung lobe quantification can support decision-making on PE diagnosis based on the ventilation-perfusion ratio in clinical practice.\u0000\u0000\u0000METHODS\u0000A study cohort of 100 patients (39 male, 61 female, age 64.8±15.8 years) underwent ventilation/perfusion single photon emission computed tomography (V/Q-SPECT/CT) to exclude acute PE on SPECT/CT OPTIMA NM/CT 640 (GE Healthcare). Two 3D lung lobe quantification software tools (Q. Lung: Xeleris 4.0, GE Healthcare and LLQ: Hermes Hybrid 3D Lung Lobar Quantification, Hermes Medical Solutions) were used to evaluate the numerical lobar ventilation/perfusion ratio (VQR) and lobar volume/perfusion ratio (VPR). A test of linearity and equivalence of the two 3D software tools was performed using Pearson, Spearman, quadratic weighted kappa and the mean squared deviation for VPR/VQR. An algorithm was developed that identified PE candidates using ROC analysis. The agreement between the PE findings of an experienced nuclear medicine expert and the calculated PE candidates was represented by the magnitude of the YOUDEN index (J) and the size of the area under the receiver operating curve (AUC).\u0000\u0000\u0000RESULTS\u0000Both 3D software tools showed good comparability. The YOUDEN index for QLUNG(VPR/VQR)/LLQ(VPR/VQR) was in the range from 0.2 to 0.5. The mean AUC averaged over all lung lobes for QLUNG(VPR) was 0.66, CI95%: ±14.0%, for QLUNG(VQR) 0.66, CI95%: ±13.3%, for LLQ(VPR) 0.64, CI95%: ±14.7% and for LLQ(VQR) 0.65, CI95%: ±13.1%.\u0000\u0000\u0000CONCLUSION\u0000This study reveals that 3D software tools are feasible for numerical PE detection. The clinical decision can be supported by using a numerical algorithm based on ROC analysis.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140723637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FDG-PET/CT is a powerful tool to predict and evaluate response to chimeric antigen receptor (CAR) T-cell therapy in Non-Hodgkin-Lymphoma (NHL). FDG-PET/CT是预测和评估非霍奇金淋巴瘤（NHL）嵌合抗原受体（CAR）T细胞疗法反应的有力工具。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-04-09 DOI: 10.1055/a-2283-8417

C. Wielenberg, J. Fostitsch, Christian Volz, Reinhard Marks, K. Michalski, Ralph Wäsch, R. Zeiser, Juri Ruf, P. T. Meyer, Claudius Klein

{"title":"FDG-PET/CT is a powerful tool to predict and evaluate response to chimeric antigen receptor (CAR) T-cell therapy in Non-Hodgkin-Lymphoma (NHL).","authors":"C. Wielenberg, J. Fostitsch, Christian Volz, Reinhard Marks, K. Michalski, Ralph Wäsch, R. Zeiser, Juri Ruf, P. T. Meyer, Claudius Klein","doi":"10.1055/a-2283-8417","DOIUrl":"https://doi.org/10.1055/a-2283-8417","url":null,"abstract":"Chimeric antigen receptor (CAR) T-cell therapy has dramatically shifted the landscape of treatment especially for Non-Hodgkin-Lymphoma (NHL). This study evaluates the role of fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) in NHL treated with CAR T-cell therapy concerning response assessment and prognosis.We evaluated 34 patients with NHL who received a CAR T-cell therapy between August 2019 and July 2022. All patients underwent a pre-therapeutic FDG-PET/CT (PET-0) 6 days prior and a post-therapeutic FDG-PET/CT (PET-1) 34 days after CAR T-cell therapy. Deauville score (DS) was used for evaluation of response to therapy and compared to a minimum follow-up of 5 months.19/34 (55.9%) patients achieved DS ≤ 3 on PET-1, the remaining 15 (44.1%) patients had DS > 3 on PET-1. 14/19 patients with DS ≤ 3 on PET-1 had no relapsed or refractory (r/r)-disease and were still alive at last follow-up. The other 5 patients had r/r-disease and 4 of these died. Except for two patients who had no r/r-disease, all other patients (13/15) with DS > 3 on PET-1 had r/r-disease and 12 of these subsequently died. Patients with DS ≤ 3 on PET-1 had significantly better progression free survival (PFS; HR: 5.7; p < 0.01) and overall survival (OS; HR: 5.0; p < 0.01) compared to patients with DS > 3 on PET-1. In addition, we demonstrated that patients with DS ≤ 4 on PET-0 tended to have longer PFS (HR: 3.6; p = 0.05).Early FDG-PET/CT using the established DS after CAR T-cell therapy is a powerful tool to evaluate response to therapy.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140723118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of 68Ga-PSMA PET/CT on radiation treatment planning of prostate cancer patients. 68Ga-PSMA PET/CT 对前列腺癌患者放射治疗计划的影响。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-04-05 DOI: 10.1055/a-2284-0593

Felix Bock, B. Frerker, Laura Schubert, Hannes Rennau, Jens Kurth, Bernd J. Krause, Guido Hildebrandt, S. Schwarzenböck

{"title":"Impact of 68Ga-PSMA PET/CT on radiation treatment planning of prostate cancer patients.","authors":"Felix Bock, B. Frerker, Laura Schubert, Hannes Rennau, Jens Kurth, Bernd J. Krause, Guido Hildebrandt, S. Schwarzenböck","doi":"10.1055/a-2284-0593","DOIUrl":"https://doi.org/10.1055/a-2284-0593","url":null,"abstract":"AIM\u0000This study aimed to assess the impact of 68Ga-PSMA PET/CT on radiation treatment (RT) planning in prostate cancer patients with salvage (sRT) or definitive (dRT) radiotherapy.\u0000\u0000\u0000METHODS\u000038 patients (27 sRT, median PSA 0.79 ng/ml (range 0.06-12.1); 11 dRT, median PSA 4.35 ng/ml (range 1.55-55.5) underwent 68Ga-PSMA PET/CT before RT. Influence of 68Ga-PSMA PET/CT on the extent of planning target volume (PTV) and addition of PET-based boosts were assessed. Median follow up was 12 months (range 3-24).\u0000\u0000\u0000RESULTS\u000068Ga-PSMA PET/CT showed positive findings in 23/38 patients (8/23: local recurrence (LR), 11/23: nodal metastasis, 1/23: LR and nodal, 2/23: solitary bone metastasis, 1/23: oligometastatic nodal/ bone metastases). In sRT primary PTV was changed in 16/27 patients extending the PTV to the lymphatic drainage (10/16), PSMA-positive LR (3/16), bone metastases (2/16) and both nodal/bone metastases (1/16). PET-based increase of primary PTV was 116%. PET-based boosts were administered in 19/27 patients (8/19: local, 10/19: nodal, 1/19: both), median boost volume was 31.3 cm3 (range 17.2-80.2) (local) and 19.7 cm3 (range 3.0-109.3) (nodal). PTV was changed in 1/11 (9%) of dRT patients (extension of primary PTV to the lymphatic drainage (RT volume of 644.5 cm3), additional nodal boost (volume of 2.7 cm3, 23.1 Gy)). All patients showed biochemical response (mean PSA decrease 88.8 +/- 14.0%). Nadir PSA was reached 10 months (range 1-17) after end of RT (median 0.07 ng/ml, range 0.002-3.96). Within a median 12 months follow-up (range 3-22/8-24 in sRT/dRT), median PSA was 0.05 ng/ml (range 0.002-8.5) (sRT) and 0.26 ng/ml (range 0.02-2.68) (dRT).\u0000\u0000\u0000CONCLUSIONS\u000068Ga-PSMA PET/CT influenced sRT planning in almost 63% and dRT in 9% of patients by change of PTV and additional boosts.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140739552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When Exercise Echoes: Unusual Tc99m HDP Uptake in Thigh Adductors Post-Workout. 运动时的回声：运动后大腿内收肌对 Tc99m HDP 的异常摄取。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-04-05 DOI: 10.1055/a-2289-4301

Michael C.M. Gammel, K. Hansen, Wolfgang Weber, I. Rauscher

引用次数: 0

Intrapankreatische Nebenmilz imitiert NET mit falsch positivem Somatostatin-Rezeptor-PET/CT (68Ga-DOTA-TOC-PET/CT). 胰腺内继发性脾脏模拟 NET，体生长抑素受体 PET/CT 呈假阳性（68Ga-DOTA-TOC-PET/CT）。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-04-01 Epub Date: 2024-03-25 DOI: 10.1055/a-2166-7025

Saher Saeed, Ioannis Dimopoulos, Nehara Begum, Jan Robert Kröger

引用次数: 0