Nuklearmedizin. Nuclear medicine最新文献

{"title":"Influence of CT metal artifact reduction on SPECT/CT quantification of bone scintigraphy - Retrospective study for selected types of metal implants.","authors":"Amelie Kugler,&nbsp;Torsten Kuwert,&nbsp;Philipp Ritt,&nbsp;Andreas Grings","doi":"10.1055/a-1883-9281","DOIUrl":"https://doi.org/10.1055/a-1883-9281","url":null,"abstract":"<p><strong>Aim: </strong>Implanted metal prostheses can cause severe artifacts in reconstructed computed tomography (CT) images. To reduce the diagnostic impact of these artifacts and improve attenuation correction in single photon emission computed tomography (SPECT), an algorithm of iterative metal artifact reduction (iMAR) for SPECT/CT systems was developed. The aims of this study were (a) to assess the difference in visual image quality by comparing CT and SPECT images reconstructed with and without iMAR and (b) to determine the influence of iMAR on quantitative ^99mTc-uptake in SPECT/CT.</p><p><strong>Methods: </strong>This retrospective study includes 21 patients with implanted metal prostheses who underwent SPECT/CT bone scintigraphy. CT data were reconstructed with iMAR and without (noMAR) and were used for attenuation correction of SPECT data for xSPECT Quant and xSPECT Bone reconstruction. The effect of iMAR on image quality was evaluated by visual analysis and the effect on quantitative SPECT/CT was assessed by measuring HU values and absolute uptake values (kBq/mL) in volumes of interest (VOIs).</p><p><strong>Results: </strong>There was a significant reduction of visible metal artifacts with iMAR (p<0.01) in the CT images, but visual differences in the SPECT images were minor. The values of quantitative tracer uptake in VOIs near metal implants were lower for iMAR vs. noMAR xSPECT Quant (p<0.01). Only VOIs near metal showed significant differences in HU values, which were 14.6% lower for iMAR CT (p<0.01).</p><p><strong>Conclusion: </strong>The use of iMAR reduces metal artifacts in CT and improves the perceived image quality. Although in some cases a significant difference in the quantitative evaluation of SPECT/CT was observed, the influence of iMAR can be considered small in relation to other factors in the clinical setting.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"449-457"},"PeriodicalIF":1.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40694498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPORTANCE of PRETREATMENT 18F-FDG PET/CT TEXTURE ANALYSIS in PREDICTING EGFR and ALK MUTATION in PATIENTS with NON-SMALL CELL LUNG CANCER.","authors":"Nurşin Agüloğlu,&nbsp;Ayşegül Aksu,&nbsp;Murat Akyol,&nbsp;Nuran Katgı,&nbsp;Tuğçe Çiftçi Doksöz","doi":"10.1055/a-1868-4918","DOIUrl":"https://doi.org/10.1055/a-1868-4918","url":null,"abstract":"<p><strong>Objective: </strong>Identification of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR) mutation types is of great importance before treatment with tyrosine kinase inhibitors (TKIs). Radiomics is a new strategy for noninvasively predicting the genetic status of cancer. We aimed to evaluate the predictive power of 18F-FDG PET/CT-based radiomic features for mutational status before treatment in non-small cell lung cancer (NSCLC) and to develop a predictive model based on radiomic features.</p><p><strong>Methods: </strong>Images of patients who underwent 18F-FDG PET/CT for initial staging with the diagnosis of NSCLC between January 2015 and July 2020 were evaluated using LIFEx software. The region of interest (ROI) of the primary tumor was established and volumetric and textural features were obtained. Clinical data and radiomic data were evaluated with machine learning (ML) algorithms to create a model.</p><p><strong>Results: </strong>For EGFR mutation prediction, the most successful machine learning algorithm obtained with GLZLM_GLNU and clinical data was Naive Bayes (AUC: 0.751, MCC: 0.347, acc: 71.4%). For ALK rearrangement prediction, the most successful machine learning algorithm obtained with GLCM_correlation, GLZLM_LZHGE and clinical data was evaluated as Naive Bayes (AUC: 0.682, MCC: 0.221, acc: 77.4%).</p><p><strong>Conclusions: </strong>In our study, we created prediction models based on radiomic analysis of 18F-FDG PET/CT images. Tissue analysis with ML algorithms are non-invasive methods for predicting ALK rearrangement and EGFR mutation status in NSCLC, which may be useful for targeted therapy selection in a clinical setting.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"433-439"},"PeriodicalIF":1.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40634572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Utility of C-Reactive Protein and White Blood Cell Count for Scheduling an [18F]FDG PET/CT in Patients with Giant Cell Arteritis.","authors":"Konstanze V Guggenberger,&nbsp;Marius L Vogt,&nbsp;Steven P Rowe,&nbsp;Takahiro Higuchi,&nbsp;Marc Schmalzing,&nbsp;Hans-Peter Tony,&nbsp;Andreas K Buck,&nbsp;Thorsten A Bley,&nbsp;Matthias Fröhlich,&nbsp;Rudolf A Werner","doi":"10.1055/a-1830-7767","DOIUrl":"https://doi.org/10.1055/a-1830-7767","url":null,"abstract":"<p><strong>Objectives: </strong>2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) PET/CT can be utilized in patients with giant cell arteritis (GCA), but pretest probability of established laboratory marker such as C-reactive protein (CRP) and white blood cell count (WBC) has not been defined yet. We aimed to elucidate the clinical utility of CRP and WBC for scheduling an [¹⁸F]FDG scan.</p><p><strong>Methods: </strong>18 treatment-naïve GCA patients and 14 GCA subjects with anti-inflammatory treatment (glucocorticoids or comparable drugs), who underwent [¹⁸F]FDG PET/CT and who had no other inflammatory disease at time of scan, were identified. A semi-quantitative analysis in 11 vessel segments was conducted, with averaged jugular vein, healthy liver and lung tissue (Target-to-background ratio [TBR]_{VJ/liver/lung}) serving as background. Derived TBR were then correlated with CRP and WBC at time of PET using Spearman's correlation.</p><p><strong>Results: </strong>For all treatment-naïve patients, TBR_VJ was 2.3±1.1 (95%CI, 2.2-2.5), TBR_liver was 1.0±0.5 (95%CI, 0.9-1.0) and average TBR_lung was 6.3±3.6 (95%CI, 5.8-6.8). No significant correlation was noted for either CRP (TBR_VJ: R=-0.19; TBR_liver: R=-0.03; TBR_lung: R=-0.17; each P ≥ 0.44) or for WBC (TBR_VJ: R=-0.40; TBR_liver: R=-0.32; TBR_lung: R=-0.37; each P ≥ 0.10). Similar results were recorded for patients under treatment at time of PET. Again, no significant correlation was reached for either CRP (TBR_VJ: R=-0.17; TBR_liver: R=-0.28; TBR_lung: R=-0.09; each P ≥ 0.32) or WBC (TBR_VJ: R=-0.06; TBR_liver: R=-0.13; TBR_lung: R=0.06; each P ≥ 0.65).</p><p><strong>Conclusions: </strong>In GCA patients with and without anti-inflammatory treatment, CRP and WBC did not substantially correlate with TBR at time of scan. Given the rather limited pretest probability of those parameters, such laboratory values may have less diagnostic utility to order an [¹⁸F]FDG PET/CT.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"425-432"},"PeriodicalIF":1.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40634574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants and clinical significance of negative scintigraphic findings in primary hyperparathyroidism: a retrospective observational study.","authors":"Michael Neuberger,&nbsp;Jan Axl Dropmann,&nbsp;Axel Kleespies,&nbsp;Heinrich Fuerst","doi":"10.1055/a-1868-5050","DOIUrl":"https://doi.org/10.1055/a-1868-5050","url":null,"abstract":"<p><strong>Aim: </strong>In patients with recurrent primary hyperparathyroidism (pHPT) or preceding thyroid operation, scintigraphic localization of the pathological parathyroid gland is sometimes unsuccessful. Reason for diagnostic failure, and its clinical relevance is poorly understood.</p><p><strong>Methods: </strong>This retrospective observational study in patients suffering from a pHPT evaluated independent predictors of a negative preoperative scintigraphy (SC) result, and its relevance for intraoperative outcome using logistic regression analysis.</p><p><strong>Results: </strong>Among 86 pHPT patients scheduled for parathyroid operation, 63 (73%) had a history of a preceding thyroid or parathyroid operation. Preoperative SC could not identify an adenoma in 30 patients (34.9%), and in 12 patients (14.0%), the surgeon was subsequently unable to localize abnormal parathyroid tissue. Preoperative parathyroid hormone concentration was the only significant independent predictor of a negative SC finding (non-linear and indirect association). Independent from surgical history, an unsuccessful intraoperative focus localization was exclusively predicted by preoperative ultrasonographic (US) and SC findings (OR per diagnostic category 2.98; 95%-CI 1.03-8.58, p=0.043, and OR 2.26; 95%-CI: 1.10-4.63, p=0.027, respectively). Compared to exclusive US, however, the combination of SC and US significantly increased the sensitivity and predictive power to identify patients at a high risk for a complicated surgical procedure.</p><p><strong>Conclusion: </strong>In patients before parathyroidectomy, a low preoperative parathyroid hormone concentration is significantly associated with a high likelihood for a negative SC finding. Combining US with SC before operation significantly increases the chance to identify patients prone to negative intraoperative findings.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"440-448"},"PeriodicalIF":1.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40575473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepancy of PSMA PET imaging and bone scan showing limited value of bone scan and CT in evaluation of extent of bone involvement.","authors":"Daniel Alexander Hescheler,&nbsp;Lars Stegger,&nbsp;Katrin Schlack,&nbsp;Martin Bögemann,&nbsp;Kambiz Rahbar","doi":"10.1055/a-1809-4570","DOIUrl":"https://doi.org/10.1055/a-1809-4570","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"414-415"},"PeriodicalIF":1.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40493632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Nuclear Medicine Physicians: A threatened species?]","authors":"Lutz S Freudenberg,&nbsp;Ben J Freudenberg,&nbsp;Rigobert Klett,&nbsp;Ken Herrmann","doi":"10.1055/a-1907-4122","DOIUrl":"https://doi.org/10.1055/a-1907-4122","url":null,"abstract":"Die demografische Entwicklung in Deutschland führt zu einem ärztlichen Nachwuchsmangel. Ziel dieser Arbeit ist es, aus den von der Bundesärztekammer (BÄK) veröffentlichten Ärztestatistiken der letzten 25 Jahre die Entwicklung und den aktuellen demografischen Status der Nuklearmedizin in Deutschland darzustellen und deren Konsequenzen aufzuzeigen.\u0000 Die seit 1996 von der BÄK jährlich veröffentlichten Zahlen der ärztlichen Versorgung in Deutschland wurden systematisch im Hinblick auf die Altersentwicklung und die Geschlechterverteilung in den Fächern Nuklearmedizin, Radiologie und Strahlentherapie zusammengefasst und mit einer deskriptiven Statistik ausgewertet.\u0000 Die Anzahl der berufstätigen Fachärzt*innen hat sich von 1996–2021 in der Nuklearmedizin um 114% erhöht mit einer deutlichen Verschiebung der Altersstruktur in die älteren Altersgruppen: 2021 lag der Anteil der Ärzt*innen unter 40 Jahren bei 13,0% in der Nuklearmedizin und bei 21,0% in der Radiologie und derjenige Anteil über 60 Jahren bei 27,1% in der Nuklearmedizin und bei 22,3% in der Radiologie. Der Anteil an Frauen lag im Jahr 2021 in der Medizin insgesamt bei 48,5%, in der Nuklearmedizin, Radiologie und Strahlentherapie bei 34,4%, 37,1% bzw. 48,0%.\u0000 Die Fachärzt*innen in der Nuklearmedizin sind 2021 deutlich älter als diejenigen in der Strahlentherapie und Radiologie, und der Anteil von Frauen ist unterdurchschnittlich. Wenn die Nuklearmedizin als eigenständiges Fach ihrer klinischen Verantwortung gerecht werden will und eigenständig bestehen bleiben möchte, müssen die Bemühungen vor allem um den weiblichen medizinischen Nachwuchs in der nuklearmedizinischen Gemeinschaft eine maximale Priorität bekommen.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"358-366"},"PeriodicalIF":1.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40634573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring orthodontic tooth movement in rats after piezocision by bone scintigraphy.","authors":"Nicola Beindorff,&nbsp;Nikolaos Papadopoulos,&nbsp;Stefan Hoffmann,&nbsp;Ajay-Mohan Mohan,&nbsp;Mathias Lukas,&nbsp;Winfried Brenner,&nbsp;Paul-Georg Jost-Brinkmann,&nbsp;Thomas Präger","doi":"10.1055/a-1816-6825","DOIUrl":"https://doi.org/10.1055/a-1816-6825","url":null,"abstract":"<p><strong>Aim: </strong>Piezocision, corticocision of mineralized tissue by ultrasound showed promising results in accelerating tooth movement induced by orthodontic appliances although the biologic effects of this procedure are not well-understood so far. The aim of this study was to investigate the impact of piezocision on bone remodeling in rats by bone SPECT imaging.</p><p><strong>Material and methods: </strong>Ten male Wistar rats underwent surgical placement of orthodontic appliances on each side of the maxilla followed by piezocision on one side only. Each rat underwent ^99mTc-MDP bone SPECT/CT imaging before surgery (T0), and 2 (T1) and 4 weeks (T2) after surgery. Bone uptake is expressed as median [IQR] min-max in percentage of the injected activity per ml computed from the 10 voxels with the highest uptake (%IAmax10/ml).</p><p><strong>Results: </strong>Pooled data regardless of the piezocision showed a significant increase in bone uptake from T0 (3.2 [2.8-3.9] 2.6-4.9) to T1 (4.4 [3.8-4.6] 3.4-4.8; p = 0.001). Thereafter, the uptake decreased to T2 (3.8 [3.1-4.4] 2.8-4.8; p = 0.116). No significant differences in bone uptake were found between the maxilla sides without and with piezocision: T1: without (4.3 [3.8-4.5] 3.4-4.8) vs. with (4.5 [3.7-4.6] 3.5-4.7; p=0.285), T2: without (4.0 [3.1-4.5] 2.8-4.8) vs. with (3.7 [3.0-4.4] 2.8-4.8; p=0.062).</p><p><strong>Conclusion: </strong>^99mTc-MDP bone SPECT imaging in rats was able to reproduce changes in bone uptake in the maxilla after placement of orthodontic appliances inducing measurable tooth movement. An additional effect of piezocision on bone remodeling in terms of bone uptake was not detectable which is probably due to the pronounced and significant effects induced by the orthodontic appliances per se, which may mask the potential effects of additional piezocision.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"402-409"},"PeriodicalIF":1.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40649062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardized 18F-FDG PET/CT radiomic features provide information on PD-L1 expression status in treatment-naïve patients with non-small cell lung cancer.","authors":"Ruiyun Zhang,&nbsp;Wolfgang Hohenforst-Schmidt,&nbsp;Claus Steppert,&nbsp;Zsolt Sziklavari,&nbsp;Christian Schmidkonz,&nbsp;Armin Atzinger,&nbsp;Torsten Kuwert,&nbsp;Thorsten Klink,&nbsp;William Sterlacci,&nbsp;Arndt Hartmann,&nbsp;Michael Vieth,&nbsp;Stefan Förster","doi":"10.1055/a-1816-6950","DOIUrl":"https://doi.org/10.1055/a-1816-6950","url":null,"abstract":"<p><strong>Purpose: </strong>To study the relationship between standardized 18F-FDG PET/CT radiomic features and clinicopathological variables and programmed death ligand-1 (PD-L1) expression status in non-small cell lung cancer (NSCLC) patients.</p><p><strong>Methods: </strong>58 NSCLC patients with preoperative 18F-FDG PET/CT scans and postoperative results of PD-L1 expression were retrospectively analysed. A standardized, open-source software was used to extract 86 radiomic features from PET and low-dose CT images. Univariate analysis and multivariate logistic regression were used to find independent predictors of PD-L1 expression. The Area Under the Curve (AUC) of receiver operating characteristic (ROC) curve was used to compare the ability of variables and their combination in predicting PD-L1 expression.</p><p><strong>Results: </strong>Multivariate logistic regression resulted in the PET radiomic feature GLRLM_LGRE (Odds Rate (OR): 0.300 vs 0.114, 95% confidence interval (CI): 0.096-0.931 vs 0.021-0.616, in NSCLC and adenocarcinoma respectively) and the CT radiomic feature GLZLM_SZE (OR: 3.338 vs 7.504, 95%CI: 1.074-10.375 vs 1.382-40.755, in NSCLC and adenocarcinoma respectively), being independent predictors of PD-L1 status. In NSCLC group, after adjusting for gender and histology, the PET radiomic feature GLRLM_LGRE (OR: 0.282, 95%CI: 0.085-0.936) remained an independent predictor for PD-L1 status. In the adenocarcinoma group, when adjusting for gender the PET radiomic feature GLRLM_LGRE (OR: 0.115, 95%CI: 0.021-0.631) and the CT radiomic feature GLZLM_SZE (OR: 7.343, 95%CI: 1.285-41.965) remained associated with PD-L1 expression.</p><p><strong>Conclusion: </strong>NSCLC and adenocarcinoma with PD-L1 expression show higher tumour heterogeneity. Heterogeneity-related 18F-FDG PET and CT radiomic features showed good ability to non-invasively predict PD-L1 expression.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"385-393"},"PeriodicalIF":1.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40409517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Radioiodine testing in clinical routine: Status in Germany 2021].","authors":"Paniz Akbarzadeh Taghavi,&nbsp;Tobias Fabiunke,&nbsp;Winfried Brenner","doi":"10.1055/a-1868-5116","DOIUrl":"https://doi.org/10.1055/a-1868-5116","url":null,"abstract":"<p><strong>Introduction and aim: </strong>According to the German guideline on Radiation Protection in Medicine, the activity to be applied for radioiodine therapy of benign thyroid diseases is determined for each patient by means of the radioiodine test (RJT). The aim of this study is to record the different parameters of the RJT.</p><p><strong>Material and methods: </strong>A web-based questionnaire was sent to all nuclear medicine departments in Germany via the DGN office. Parameters regarding tracer and activity, type of probe measurement, number and timing of measurements, use of fixed effective half-lives (eHWZ), calculation model and organ doses were requested. An assessment of continuous measurement of the thyroid iodine uptake over seven days by a wearable probe system was also requested.</p><p><strong>Results: </strong>38 of 94 facilities responded to the questionnaire. Major differences in RJT implementation were found concerning the parameters number and timing of measurements, probe-patient distance, use of fixed disease-specific eHWZ, and intended organ dose. Despite the DGN Guideline and DIN 6861-1, 74% of the facilities still use the simplified Marinelli formula from the DGN Recommendation of 1998. Only 8% have switched to the two-compartment model. 84% of the institutions expect that a wearable probe system could improve the calculation of the radioiodine activity necessary for treatment, but only 57% expect an improvement in the therapeutic outcome.</p><p><strong>Conclusions: </strong>The methodology of RJT in Germany is heterogeneous and still based on the \"Marinelli method\" in most institutions despite new guidelines and recommendations. A continuous measurement of the iodine kinetics using a wearable probe system could result in further improving the radioiodine test in addition to the newer calculation algorithms.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"367-375"},"PeriodicalIF":1.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual accumulation of 177Lu-DOTATATE at the injection site of a COVID-19 vaccination.","authors":"Christof Scheer,&nbsp;Michael Jüptner,&nbsp;Timo Maier,&nbsp;Ulf Lützen","doi":"10.1055/a-1856-4238","DOIUrl":"https://doi.org/10.1055/a-1856-4238","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"410-413"},"PeriodicalIF":1.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40694497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}