Nuklearmedizin. Nuclear medicine最新文献_第10页

Increased off-target binding of [18F]florbetaben in the skull of women with reduced skull density. 颅骨密度降低的妇女颅骨中[18F]氟贝他本的脱靶结合增加。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-08-01 Epub Date: 2024-02-22 DOI: 10.1055/a-2246-5292

Noah Hipp, Kim Lea Young, Ivayla Ilieva Apostolova, Susanne Klutmann, Iris Hardewig, Norman Koglin, Jürgen Gallinat, Ralph Buchert

{"title":"Increased off-target binding of [18F]florbetaben in the skull of women with reduced skull density.","authors":"Noah Hipp, Kim Lea Young, Ivayla Ilieva Apostolova, Susanne Klutmann, Iris Hardewig, Norman Koglin, Jürgen Gallinat, Ralph Buchert","doi":"10.1055/a-2246-5292","DOIUrl":"10.1055/a-2246-5292","url":null,"abstract":"Aim: To investigate the relationship between off-target binding of the amyloid tracer [18F]florbetaben (FBB) in the skull and skull density.Methods: Forty-three consecutive patients were included retrospectively (age 70.2±7.5y, 42% females, 65% amyloid-positive). For each patient, CT skull density (in Hounsfield units) and (late) FBB uptake in the skull were obtained using an individual skull mask generated by warping the skull tissue probability map provided by the statistical parametric mapping software package (version SPM12) to the native patient space. Skull FBB uptake (mean of the 10% hottest voxels) was scaled to the individual median FBB uptake in the pons. The association between skull FBB uptake and skull density was tested by correlation analyses. Univariate analysis of variance (ANOVA) of skull FBB uptake with dichotomized skull density (low: ≤ median, high), sex (female, male) and amyloid-status (positive, negative) as between-subjects factors was used to assess the impact of sex and amyloid status.Results: There was a significant inverse correlation between skull FBB uptake and skull density (Pearson correlation coefficient -0.518, p < 0.001; Spearman rho -0.321, p = 0.036). The ANOVA confirmed the bone density effect on the FBB uptake in the skull (p = 0.019). In addition, sex (p = 0.012) and density*sex interaction (p = 0.016) had a significant impact. Skull FBB uptake was significantly higher in females with low skull density than for all other combinations of sex and skull density. Amyloid status did not reach statistical significance (p = 0.092).Conclusion: Off-target binding of FBB in the skull is inversely associated with skull density. The relationship is mainly driven by females. Amyloid status does not have a major impact on skull FBB binding.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"247-251"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Nuclear medicine procedure guideline for sentinel lymph node localization]. [前哨淋巴结定位核医学程序指南]。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-08-01 Epub Date: 2024-05-24 DOI: 10.1055/a-2319-8306

M Schmidt, M Hohberg, M Felcht, T Kühn, M Eichbaum, B J Krause, B K Zöphel, J Kotzerke

{"title":"[Nuclear medicine procedure guideline for sentinel lymph node localization].","authors":"M Schmidt, M Hohberg, M Felcht, T Kühn, M Eichbaum, B J Krause, B K Zöphel, J Kotzerke","doi":"10.1055/a-2319-8306","DOIUrl":"10.1055/a-2319-8306","url":null,"abstract":"The authors present a procedure guideline for scintigraphic detection of sentinel lymph nodes in malignant melanoma, in breast cancer, in penile and vulva tumors, in head and neck cancer, and in prostate carcinoma. Important goals of sentinel lymph node scintigraphy comprise reduction of the extent of surgery, lower postoperative morbidity and optimization of histopathological examination focussing on relevant lymph nodes. Sentinel lymph node scintigraphy itself does not diagnose tumorous lymph node involvement and is not indicated when lymph node or distant metastases have been definitely diagnosed before sentinel lymph node scintigraphy. Procedures are compiled with the aim to reliably localise sentinel lymph nodes with a high detection rate typically in early tumour stages. New aspects in this guideline are new radiopharmaceuticals such as tilmanocept and Tc-99m-PSMA and SPECT/CT allowing an easier anatomical orientation. Initial dynamic lymphoscintigraphy in breast cancer is of little significance nowadays. Radiation exposure is low so that pregnancy is not a contraindication for sentinel lymph node scintigraphy. A one-day protocol should preferentially be used. Even with high volumes of scintigraphic sentinel lymph node procedures surgeons, theatre staff and pathologists receive a radiation exposure < 1 mSv/year so that they do not require occupational radiation surveillance. Aspects of quality control were included (scintigraphy, quality control of gamma probe, 6 h SLN course for surgeons, certified breast centers, medical surveillance center).","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"233-246"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

18F-FDG PET/CT images of adult pulmonary blastoma: a case report. 成人肺泡瘤的 18F-FDG PET/CT 图像：病例报告。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-08-01 Epub Date: 2024-02-07 DOI: 10.1055/a-2237-8775

Minhan Chen, Yao Liu

引用次数: 0

Incidental Papillary Thyroid Carcinoma Detected by Ga-68 DOTATATE PET/CT: A Rare Case Study and Clinical Considerations. 通过Ga-68 DOTATATE PET/CT检测到的偶发甲状腺乳头状癌：罕见病例研究与临床考虑。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-08-01 Epub Date: 2024-01-23 DOI: 10.1055/a-2238-4186

Adem Maman

引用次数: 0

Cervical Cancer Metastasis to the Stomach Masquerading as Primary Gastric Cancer: A Case Report of a Rare Metastasis Detected via 18F-FDG PET/CT. 宫颈癌转移至胃部，伪装成原发性胃癌：通过 18F-FDG PET/CT 检测出罕见转移瘤的病例报告。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-06-01 Epub Date: 2024-01-08 DOI: 10.1055/a-2224-9673

Ozge Vural Topuz, Sidar Bağbudar

引用次数: 0

Incidental Finding of a Pancreatic Adenocarcinoma on [68Ga]Ga-PSMA-11 PET/CT in a mCRPC patient under [177Lu]Lu-PSMA-617 Radioligand Therapy. 一名接受[177Lu]Lu-PSMA-617放射性配体治疗的 mCRPC 患者在[68Ga]Ga-PSMA-11 PET/CT 上意外发现胰腺腺癌。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-06-01 Epub Date: 2024-01-08 DOI: 10.1055/a-2221-3220

Giulia Santo, Gianpaolo Di Santo, Bettina Zelger, Irene Virgolini

引用次数: 0

Global Research Output of Lutetium-177 PSMA in Prostate Cancer: Bibliometric and Altmetric Analyses. 前列腺癌中 Lutetium-177 PSMA 的全球研究成果：文献计量学和 Altmetric 分析。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-06-01 Epub Date: 2024-01-23 DOI: 10.1055/a-2221-3036

Rakan Al-Rashdan, Haneen Al-Abdallat, Mike Machaba Sathekge, Siroos Mirzaei, Mohammed Shahait, Khaled Al-Khawaldeh, Ahmed Saad Abdlkadir, Szeting Lee, Akram Al-Ibraheem

{"title":"Global Research Output of Lutetium-177 PSMA in Prostate Cancer: Bibliometric and Altmetric Analyses.","authors":"Rakan Al-Rashdan, Haneen Al-Abdallat, Mike Machaba Sathekge, Siroos Mirzaei, Mohammed Shahait, Khaled Al-Khawaldeh, Ahmed Saad Abdlkadir, Szeting Lee, Akram Al-Ibraheem","doi":"10.1055/a-2221-3036","DOIUrl":"10.1055/a-2221-3036","url":null,"abstract":"Aim: The integration of innovative radio-pharmaceutical agents targeting prostate-specific membrane antigen (PSMA) within nuclear medicine has transformed prostate cancer detection and management. This study aims to investigate the present landscape of [177Lu]Lu-PSMA in prostate cancer, elucidating trends, global contributions, scholarly outlets, institutions, and thematic concentrations with an aim to inform forthcoming research endeavors.Methods: We systematically probed the Scopus repository for relevant [177Lu]Lu-PSMA literature. An assessment of bibliometric and altmetric data was carried out. Finally, we assessed the correlation between the altmetric attention scores and the number of citations for the retrieved data.Results: Spanning January 2015 to July 2023, the study encompassed 466 articles concerning [177Lu]Lu-PSMA therapy for prostate cancer. Predominant citation accolades gravitated towards metastatic castration-resistant prostate cancer investigations and assessments of [177Lu]Lu-PSMA therapy's safety and efficacy. Further research encompassed adverse effects linked to [177Lu]Lu-PSMA intervention, including xerostomia, thrombocytopenia, anemia, and fatigue. Germany emerged as the primary academic contributor, with The Journal of Nuclear Medicine dominating publications (n = 55). A moderate significant correlation was detected between the number of citations and altmetric attention scores .Conclusion: The findings highlight the growing interest and advancements in the utilization of [177Lu]Lu-PSMA therapy in prostate cancer and offer a comprehensive global perspective on future research directions.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"188-198"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139543860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of FDG- PET/CT in Detecting Bone Marrow Involvement in Childhood Solid Tumors. FDG PET/CT 在检测儿童实体瘤骨髓受累方面的作用。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-06-01 Epub Date: 2024-01-08 DOI: 10.1055/a-2224-9441

Esra Arslantaş, Ali Ayçiçek, Burcu Esen Akkas, Tuba Nur Tahtakesen Güçer, Sultan Okur Acar, Ayse Özkan Karagenc, Sibel Akpınar Tekgündüz, Cengiz Bayram

{"title":"The Role of FDG- PET/CT in Detecting Bone Marrow Involvement in Childhood Solid Tumors.","authors":"Esra Arslantaş, Ali Ayçiçek, Burcu Esen Akkas, Tuba Nur Tahtakesen Güçer, Sultan Okur Acar, Ayse Özkan Karagenc, Sibel Akpınar Tekgündüz, Cengiz Bayram","doi":"10.1055/a-2224-9441","DOIUrl":"10.1055/a-2224-9441","url":null,"abstract":"Purpose: To compare the results of 18F-Fluorodeoxy positron emission tomography/computed tomography (18 F-FDG-PET/CT) and bone marrow biopsy (BMB) procedures in the initial evaluation of bone marrow involvement (BMI) in pediatric solid tumors.Methods: We conducted a retrospective analysis of newly diagnosed pediatric cases with lymphoma, neuroblastoma, Ewing sarcoma, rhabdomyosarcoma. Each case underwent both PET-CT imaging and BMB. Presence of tumor infiltration in BMB specimens and/or positive FDG-PET/CT findings indicate as BMI were regarded as true positive results.Results: Sixty-four patients were included in the study. BMI was detected in 23/64 (36%) patients, FDG-PET/CT imaging and BMB results were concordant in 54/64 patients. In 9/64 patients the finding was FDG-PET/CT (+), BMB (-) indicating a false negative BMB result. In only 1/64 patients FDG- PET/CT (-), BMB (+), indicating a false negative FDG-PET/CT result. In the whole patient group, the sensitivity, specificity, positive predictive value and negative predictive value of PET/CT and BMB in detecting bone marrow involvement were 95.6%, 100%, 100% and 97.6% and 60.8 %, 100%, 100% and 82%, respectively.Conclusion: PET/CT has a high sensitivity and specificity for the assessing marrow involvement in pediatric solid tumors. We believe that PET/CT imaging should be performed as the first step in diagnostic staging, and BMB may not be necessary in every patient, only in patients with suspicious PET/CT results for bone marrow involvement. Additionally, for a more precise determination of bone marrow involvement, it is reasonable to perform BMB from FDG-retaining areas, using PET/CT as a guide tool.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"207-212"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic accuracy of artificial intelligence-enabled vectorcardiography versus myocardial perfusion SPECT in patients with suspected or known coronary heart disease. 人工智能矢量心电图与心肌灌注 SPECT 对疑似或已知冠心病患者的诊断准确性对比。

Nuklearmedizin. Nuclear medicine Pub Date : 2024-06-01 Epub Date: 2024-02-20 DOI: 10.1055/a-2263-2322

Simon Aydar, Hermann Knobl, Wolfgang Burchert, Oliver Lindner

{"title":"Diagnostic accuracy of artificial intelligence-enabled vectorcardiography versus myocardial perfusion SPECT in patients with suspected or known coronary heart disease.","authors":"Simon Aydar, Hermann Knobl, Wolfgang Burchert, Oliver Lindner","doi":"10.1055/a-2263-2322","DOIUrl":"10.1055/a-2263-2322","url":null,"abstract":"Aim: The present study evaluated with myocardial perfusion SPECT (MPS) the diagnostic accuracy of an artificial intelligence-enabled vectorcardiography system (Cardisiography, CSG) for detection of perfusion abnormalities.Methods: We studied 241 patients, 155 with suspected CAD and 86 with known CAD who were referred for MPS. The CSG was performed after the MPS acquisition. The CSG results (1) p-factor (perfusion, 0: normal, 1: mildly, 2: moderately, 3: highly abnormal) and (2) s-factor (structure, categories as p-factor) were compared with the MPS scores. The CSG system was not trained during the study.Results: Considering the p-factor alone, a specificity of >78% and a negative predictive value of mostly >90% for all MPS variables were found. The sensitivities ranged from 17 to 56%, the positive predictive values from 4 to 38%. Combining the p- and the s-factor, significantly higher specificity values of about 90% were reached. The s-factor showed a significant correlation (p=0.006) with the MPS ejection fraction.Conclusions: The CSG system is able to exclude relevant perfusion abnormalities in patients with suspected or known CAD with a specificity and a negative predictive value of about 90% combining the p- and the s-factor. Since it is a learning system there is potential for further improvement before routine use.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"213-218"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139914369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Radioiodine Treatment on Quality of Life in Patients with Subclinical Hyperthyroidism: A Prospective Controlled Study. 放射性碘治疗对亚临床甲亢患者生活质量的影响：前瞻性对照研究

Nuklearmedizin. Nuclear medicine Pub Date : 2024-06-01 Epub Date: 2024-01-23 DOI: 10.1055/a-2240-8087

Rolf Larisch, John E M Midgley, Johannes W Dietrich, Rudolf Hoermann

{"title":"Effect of Radioiodine Treatment on Quality of Life in Patients with Subclinical Hyperthyroidism: A Prospective Controlled Study.","authors":"Rolf Larisch, John E M Midgley, Johannes W Dietrich, Rudolf Hoermann","doi":"10.1055/a-2240-8087","DOIUrl":"10.1055/a-2240-8087","url":null,"abstract":"Radioiodine treatment (RIT) has a high success rate in both the treatment of hyperthyroidism and improving the quality of life (QoL) of symptomatic patients. In asymptomatic patients with subclinical hyperthyroidism thyroid related QoL outcomes are less well known.Methods: Study aim was to evaluate thyroid-related QoL in patients with subclinical hyperthyroidism mostly due to toxic nodular goitre undergoing RIT, compared to a control group of euthyroid subjects. Study design was monocentric, prospective, controlled. Fifty control subjects were enrolled and 51 RIT patients. Most subjects were examined at least twice at an interval of 6 months, with visits immediately before and 6 months after treatment in the RIT group. QoL was estimated with the ThyPRO questionnaire, using its composite scale as primary outcome. Treatment effect was the mean adjusted difference (MAD) between groups over time, using repeated? measures mixed? effects models.Results: TSH concentrations were lower in the RIT group prior to treatment and recovered thereafter slightly above the level of the control group. Correspondingly, QoL improved significantly after 6 months from a worse level in the RIT group, compared to controls (MAD -10.3 [95% CI -14.9, -5.7], p<0.001). QoL improvements were strong for general items, but less pronounced for the hyperthyroid domain. Compared to controls, thyroid volume, thyroid functional capacity (SPINA-GT) and deiodinase activity (SPINA-GD) were significantly reduced in the RIT group.Conclusion: Patients with subclinical hyperthyroidism improve both biochemically and in their QoL after RIT, compared to controls. QoL assessment should have a wider role in clinical practice to complement biochemical tests and help with treatment decisions.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"176-187"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139543858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0