Nuklearmedizin. Nuclear medicine最新文献

{"title":"Clarification of a Rare and Unexpected Breast Finding on [68Ga]Ga-PSMA-11 PET scan.","authors":"Maria-Alexandra Freudewald, Tim Gansleweit, Burkhard Held, Stefan Dresel","doi":"10.1055/a-2943-5330","DOIUrl":"https://doi.org/10.1055/a-2943-5330","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potentials and Challenges of Unmanned Aerial Vehicle-Based Transport for the Time-Critical Delivery of Positron Emission Tomography Radiopharmaceuticals in Nuclear Medicine.","authors":"Olga Varlamova, Jan Bredow, Matthias Nattke, Winfried Brenner, Katharina Frentzel, Michael Starke","doi":"10.1055/a-2966-8652","DOIUrl":"https://doi.org/10.1055/a-2966-8652","url":null,"abstract":"<p><strong>Aim: </strong>Positron emission tomography radiopharmaceuticals have short physical half-lives, making transport time a key determinant of their clinical availability. This study evaluated the potential of unmanned aerial vehicle-based transport to improve radiopharmaceutical distribution compared with conventional road transport.</p><p><strong>Methods: </strong>Ground- and unmanned aerial vehicle-based transport scenarios were compared within standardized regulatory and radiopharmacy frameworks. Representative distribution routes were analysed, and radioactive decay was modelled using exponential decay kinetics. Activity preservation was evaluated for ¹⁸F, ⁶⁸Ga, and ¹¹C using representative distribution scenarios for ¹⁸F-FDG and ⁶⁸Ga-PSMA.</p><p><strong>Results: </strong>The modelling analysis predicted shorter and more predictable delivery times for unmanned aerial vehicle-based transport than for conventional road transport. The reduced transport duration increased the residual activity available at the time of administration, with the greatest benefit predicted for short-lived radionuclides. In a representative scenario, reducing the transport time from approximately 110 to 70 minutes was associated with increased residual ¹⁸F activity from approximately 50 to 64%. A corresponding increase from approximately 33 to 49% was predicted for ⁶⁸Ga, whereas ¹¹C exhibited the greatest sensitivity to transport time.</p><p><strong>Conclusion: </strong>Unmanned aerial vehicle-based transport could improve positron emission tomography radiopharmaceutical distribution by reducing decay losses, increasing operational flexibility, and enabling higher patient throughput per production batch. Clinical implementation remains limited by regulatory, technical, and environmental challenges. Experimental validation and real-world studies are needed to confirm feasibility.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Mosaic Pattern on Ventilation/Perfusion Single-Photon Emission Computed Tomography/Computed Tomography in Graft-Versus-Host Disease.","authors":"Kim Mangler, Philipp M Meyer, Armin Frille, Hans-Jonas Meyer, Georg-Nikolaus Franke, Osama Sabri, Solveig Tiepolt","doi":"10.1055/a-2966-9524","DOIUrl":"10.1055/a-2966-9524","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marinelli Equation vs. DIN 6861-1: Comparison of the Achieved Therapeutic Thyroid Dose after Radioiodine Therapy Using Different Pretherapeutic Dosimetry.","authors":"Patrick Heilfort, Olga Varlamova, Max Kranick, Jan Bredow, Michael Starke","doi":"10.1055/a-2960-8295","DOIUrl":"10.1055/a-2960-8295","url":null,"abstract":"<p><strong>Aim: </strong>Pretherapeutic dosimetry is an essential component of individualized radioiodine therapy. This study aimed to compare radioiodine therapies planned according to the Marinelli equation or DIN 6861-1:2021-11 with regard to the deviation of the planned and achieved thyroid doses in patients with benign thyroid diseases.</p><p><strong>Methods: </strong>The relative deviation of the achieved thyroid dose during radioiodine therapy from the pretherapeutically planned dose was analyzed according to the applied dosimetric method. Patient cohorts with goiter, recurrent goiter, disseminated and focal thyroid autonomy and autoimmune thyroid disease were evaluated. The cohorts were compared using the Mann-Whitney <i>U</i>- test.</p><p><strong>Results: </strong>For goiter, recurrent goiter, disseminated thyroid autonomy and focal thyroid autonomy, radioiodine therapies planned according to DIN 6861-1:2021-11 were associated with significantly smaller deviations between the planned and achieved thyroid doses than therapies planned according to the Marinelli equation. Depending on the diagnostic group, the mean relative deviation was approximately 15 to 32 percentage points lower in the DIN cohorts. The DIN cohorts also showed less variability in dose deviations. In patients with autoimmune thyroid disease, no statistically significant differences of the mean relative deviation were observed between the dosimetric methods. However, variability was also lower in the DIN cohorts.</p><p><strong>Conclusion: </strong>The use of DIN 6861-1:2021-11 is associated with improved prediction of the thyroid dose compared with the Marinelli equation and may contribute to more precise individualized planning of radioiodine therapy in patients with benign thyroid diseases.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"German Society of Nuclear Medicine procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals (09/2025).","authors":"Ralph Buchert, Philipp T Meyer, Nathalie L Albert, Henryk Barthel, Henning Boecker, Caroline Bouter, Matthias Brendel, Joachim Brumberg, Heinz Hubert Coenen, Alexander Drzezga, Gerhard Gründer, Frank Grünwald, Swen Hesse, Torsten Kuwert, Christian la Fougère, Catharina Lange, Philipp Lohmann, Christian Menzel, Isabelle Miederer, Bernd Neumaier, Axel Rominger, Christian Nikolaus Schmitz, Mathias Schreckenberger, Igor Yakushev, W Tilman Kranert","doi":"10.1055/a-2821-9573","DOIUrl":"10.1055/a-2821-9573","url":null,"abstract":"<p><strong>Abstract: </strong>This procedure guideline for brain perfusion SPECT is intended to support the planning, execution, quality control, evaluation and reporting of brain perfusion SPECT studies using the ^99 mTc-labelled radiopharmaceuticals [^99 mTc]Tc-HMPAO and [^99 mTc]Tc-ECD. It is an update and expansion built on the 2019 version of the procedure guideline. It was developed through an informal process as a consensus of the Neuroimaging Working Group of the German Society of Nuclear Medicine. It is intended for use by physicians and physical-technical staff (technologists, physicists) working in nuclear medicine.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"287-302"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Reconstructions for Renal Sestamibi SPECT/CT: A Modeled Comparison of 360-Degree Versus 180-Degree Acquisitions.","authors":"Jorge D Oldan, Jennifer A Schroeder, Mathurika Jeyasingam, Lilja B Solnes, Emi Lou Mondragon, Thad Benefield, Mohammad E Allaf, Mark Tulchinsky, Michael A Gorin, Yong Du, Steven P Rowe","doi":"10.1055/a-2914-2268","DOIUrl":"10.1055/a-2914-2268","url":null,"abstract":"<p><strong>Rationale: </strong>99m Tc-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) is a cost-effective and accurate means of characterizing indeterminate renal masses. This is scant literature on 99m Tc-sestamibi protocol optimization.</p><p><strong>Methods: </strong>We investigated the difference between modeled, quantitative 180-degree and 360-degree acquisitions for 99mTc-sestamibi SPECT/CT in a cohort of 50 patients who were prospectively enrolled on a scan-and-resect protocol. Two experienced, dual-boarded observers rated each renal mass for image quality (1-5 scale) and diagnosis (benign to malignant, 1-5 scale) in a blinded, randomized order. Ordinal logistic regression was used, incorporating random intercepts for patient and reader; inter-observer variability was assessed.</p><p><strong>Results: </strong>Image quality ratings were significantly higher for 360-degree acquisitions versus 180-degree (P<0.0001; odds ratio 0.22, 95% CI 0.12-0.39). The odds ratio was 0.22 (95% CI: 0.12, 0.39). There was insufficient evidence that the modeled angle of acquisition was associated with scan positivity (P=0.17). The odds ratio was 0.67 (95% CI: 0.37, 1.19). Diagnostic positivity ratings did not differ between reconstruction angles (P=0.17; odds ratio 0.67, 95% CI 0.37-1.19).</p><p><strong>Conclusions: </strong>Modeled 180-degree reconstructions of quantitative SPECT/CT are qualitatively inferior to quantitative reconstructions of 360-degree acquisitions, although there was no difference in the diagnostic accuracy between the reconstruction methods. These results suggest that 180-degree acquisitions are adequate for diagnosis.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"323-327"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148715143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDG-PET/CT in children with malignant diseases - comparison of a long axial field of view scanner with a standard scanner.","authors":"Wolfram A Bosbach, Valentin Manser, Carola M Bregenzer, Nasir Gözlügöl, Korbinian Krieger, Konstantinos Zeimpekis, Angela Filipa Silva Mendes, Swantje Engelbrecht, Angelo R Felgosa Cardoso, Kuangyu Shi, Axel Rominger, Hasan Sari, Paul Cumming, Clemens Mingels, Ali Afshar-Oromieh","doi":"10.1055/a-2912-4818","DOIUrl":"10.1055/a-2912-4818","url":null,"abstract":"<p><strong>Aim: </strong>[¹⁸F]FDG positron-emission-tomography/computed tomography (PET/CT) is a crucial tool in paediatric oncology for staging, treatment response assessment, and follow-up imaging. Long axial field of view (LAFOV) PET/CT is more sensitive for the detection of annihilation events than short axial field of view (SAFOV) instrumentation, thus enabling lower radiation dose and/or briefer acquisition time. In consideration of the radiation sensitivity of children, we compared the performance of LAFOV and SAFOV PET/CT in paediatric oncology.</p><p><strong>Methods: </strong>Twenty-six paediatric oncology patients (mean age 13.7 ± 4.8 y), of whom half had diagnosis of lymphoma, underwent 37 [¹⁸F]FDG PET/CT scans (12 SAFOV, 25 LAFOV). The LAFOV acquisitions (1-3 MBq/kg) were numerically rescaled to simulate 0.5-3 MBq/kg, yielding 75 LAFOV studies. Four blinded readers rated image quality on a 5-point Likert scale, and recorded various imaging metrics, statistical comparison, and power calculations.</p><p><strong>Results: </strong>LAFOV at 2 and 3 MBq/kg achieved significantly higher Likert ratings than SAFOV. LAFOV at 1 MBq/kg yielded comparable ratings to SAFOV (p=0.13), while 0.5 MBq/kg was inferior to SAFOV (p=0.012). Hepatic background SD decreased and SNR increased dose-dependently with LAFOV (p<0.001), whereas lesion SUV_max and SUV_mean remained stable across scanners. TBR was lower for LAFOV at higher doses, despite unchanged image quality. Inter-rater agreement was fair to moderate.</p><p><strong>Conclusion: </strong>LAFOV PET/CT supports [¹⁸F]FDG dose reduction without impairing image quality for lesion detection. 1 MBq/kg yielded diagnostic quality comparable to SAFOV, while 2-3 MBq/kg provided superior performance. These results support LAFOV PET/CT as a strategy to minimize radiation exposure in children.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"312-320"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[68Ga]Ga-FAPI-04 PET/CT Delineates Peritoneal Carcinomatosis in Invasive Lobular Breast Cancer with Limited FDG Avidity.","authors":"Mehmet Tarık Tatoğlu, Hatice Uslu","doi":"10.1055/a-2883-7848","DOIUrl":"10.1055/a-2883-7848","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"328-331"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Brain Metastasis in Occult Medullary Thyroid Carcinoma Using ⁶⁸Ga-DOTATATE PET/CT: A Case Report.","authors":"Muhammet Halil Baltacioglu","doi":"10.1055/a-2892-1094","DOIUrl":"10.1055/a-2892-1094","url":null,"abstract":"<p><strong>Abstract: </strong>Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that may express somatostatin receptors, enabling imaging with ⁶⁸Ga-DOTATATE PET/CT. Brain metastases from MTC are extremely rare, particularly in the absence of an identifiable primary tumor. We present a 63-year-old male with occult MTC and elevated serum calcitonin levels (27 pg/mL). ⁶⁸Ga-DOTATATE PET/CT demonstrated focal tracer uptake in the right parietal lobe (SUVmax: 9.1), which was confirmed by brain MRI as a 7-mm enhancing lesion consistent with metastasis. This case highlights the value of ⁶⁸Ga-DOTATATE PET/CT in detecting unusual metastatic presentations in occult MTC.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"321-322"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and new-onset rates of nausea and fatigue in ¹⁷⁷Lu-PSMA therapy with standardized premedication.","authors":"Wolfram A Bosbach, Karene Sriramachandran, Nasir Gözlügöl, Axel Rominger, Marco Cuzzocrea, Sabin G Pop, Gaetano Paone, Irene A Burger, Ali Afshar-Oromieh","doi":"10.1055/a-2902-0532","DOIUrl":"10.1055/a-2902-0532","url":null,"abstract":"<p><strong>Aim: </strong>PSMA-based radioligand therapy (PSMA-RLT) for metastatic castration-resistant prostate cancer (mCRPC) is associated with nausea, vomiting, and fatigue. We evaluated whether standardized premedication with glucocorticoids and antiemetics reduces these side effects.</p><p><strong>Methods: </strong>In this retrospective multicentre study, 67 mCRPC patients received 322 cycles of ¹⁷⁷Lu-PSMA-617 at three Swiss centres. All patients received 8 mg dexamethasone and 8 mg ondansetron intravenously 30 minutes before therapy. Side effects were assessed using study-specific questionnaires (195/322 returned; 61%). Baseline symptoms were documented using EORTC questionnaires in 30 patients. Biochemical response was evaluated in 36 patients using PCWG3 criteria.</p><p><strong>Results: </strong>Absolute side effect rates were: nausea within 3 days 20.9%, inter-cycle nausea 35.8%, vomiting 10.4%, and fatigue 67.2%. After correction for baseline symptoms, estimated new-onset rates were lower: 16.3%, 26.1%, 7.0%, and 6.7%, respectively. Early nausea significantly predicted inter-cycle nausea (p=0.02). Side effects followed a U-shaped pattern across cycles. No significant association was observed between side effects and PCWG3 biochemical response, though statistical power was limited.</p><p><strong>Conclusions: </strong>Absolute rates of nausea and fatigue were comparable to the VISION trial. However, new-onset rates of these two side effects were substantially lower after accounting for baseline symptoms. A protective effect of premedication with glucocorticoids and antiemetics could be the reason for this, but requires confirmation in prospective controlled studies.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"303-311"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148414475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}