Nuklearmedizin. Nuclear medicine最新文献

Correction: Divergent growth on [18F]FDG PET/CT in a case of co-existing pulmonary metastatic leiomyosarcoma and papillary thyroid carcinoma. 更正：一例同时患有肺转移性亮肌肉瘤和甲状腺乳头状癌的病例在[18F]FDG PET/CT 上出现了不同程度的生长。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2024-03-25 DOI: 10.1055/a-2286-9571

Sean Ira G Gacula, Sophie C Kunte, Lena M Unterrainer, Johannes Rübenthaler, Wolfgang G Kunz, Clemens Cyran, Adrien Holzgreve

引用次数: 0

FAPI PET/CT provides higher uptake and better target to back ground in recurrent and metastatic tumors of patients with Iodine refractory papillary thyroid cancer compared with FDG PET CT. 与 FDG PET CT 相比，FAPI PET/CT 在碘难治性甲状腺乳头状癌患者的复发和转移性肿瘤中具有更高的摄取率和更好的靶向性。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2024-01-08 DOI: 10.1055/a-2185-7746

Shaghayegh Nourbakhsh, Yalda Salehi, Saeed Farzanehfar, Reza Ghaletaki, Mohsen Bakhshi Kashi, Mehrshad Abbasi

{"title":"FAPI PET/CT provides higher uptake and better target to back ground in recurrent and metastatic tumors of patients with Iodine refractory papillary thyroid cancer compared with FDG PET CT.","authors":"Shaghayegh Nourbakhsh, Yalda Salehi, Saeed Farzanehfar, Reza Ghaletaki, Mohsen Bakhshi Kashi, Mehrshad Abbasi","doi":"10.1055/a-2185-7746","DOIUrl":"10.1055/a-2185-7746","url":null,"abstract":"The role of fibroblast activation protein inhibitor (FAPI) PET CT scan is not well documented in papillary thyroid cancer (PTC) patients. Patients with radioiodine refractory PTC and high thyroglobulin levels need PET/CT scan which is generally done by 18F FDG. In the current study, the diagnostic performance of 68Ga FAPI and FDG PET/CT scans were compared head to head in patients with radioiodine refractory PTC.Fourteen patients with negative whole body Iodine scans and high thyroglobulin levels underwent whole body PET scans with, respectively, 120-310 and 145-370 MBq 68Ga FAPI-46 and 18F FDG. SUVmax of the back ground in the blood pool and liver and the hottest, largest and average neck, mediastinum, lung and bone lesions were calculated and compared.Ten patients had at least one active (SUVmax>blood pool) lesion similarly in two scans. The liver and blood pool SUVmax values were 1.25(0.2) and 1.7(0.2) in FAPI and 2.65(0.2) and 2.0(0.2) in FDG PET images, respectively. The difference was significant (p=0.001). Standard SUV of the hottest lesion to liver was above 3 in all FAPI scans but in half of FDG scans. Target lesion number and intensity were similar between two PET studies but in a patient out of 5 pulmonary metastatic patients, pulmonary nodules were negative (SUVmax=0.9) in FDG while positive (SUVmax= 3.8) in FAPI images (i.e. 20% patient upstaged).FAPI accumulates in the recurrent and metastatic lesions of patients with Iodine refractory PTC at least as well as FDG with particular privileges as lower injected activity and lower back ground.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"188-192"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiomic signatures derived from baseline 18F FDG PET/CT imaging can predict tumor-infiltrating lymphocyte values in patients with primary breast cancer. 来自基线18F FDG PET/CT成像的放射学特征可以预测原发性乳腺癌患者的肿瘤浸润性淋巴细胞值。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2025-01-28 DOI: 10.1055/a-2512-8212

Özge Vural Topuz, Sidar Bağbudar, Ayşegül Aksu, Tuçe Söylemez Akkurt, Burcu Esen Akkaş

{"title":"Radiomic signatures derived from baseline 18F FDG PET/CT imaging can predict tumor-infiltrating lymphocyte values in patients with primary breast cancer.","authors":"Özge Vural Topuz, Sidar Bağbudar, Ayşegül Aksu, Tuçe Söylemez Akkurt, Burcu Esen Akkaş","doi":"10.1055/a-2512-8212","DOIUrl":"10.1055/a-2512-8212","url":null,"abstract":"To determine the value of radiomics data extraction from baseline 18F FDG PET/CT in the prediction of tumor-infiltrating lymphocytes (TILs) among patients with primary breast cancer (BC).We retrospectively evaluated 74 patients who underwent baseline 18F FDG PET/CT scans for BC evaluation between October 2020 and April 2022. Radiomics data extraction resulted in a total of 131 radiomic features from primary tumors. TILs status was defined based on histological analyses of surgical specimens and patients were categorized as having low TILs or moderate & high TILs. The relationships between TILs groups and tumor features, patient characteristics and molecular subtypes were examined. Features with a correlation coefficient of less than 0.6 were analyzed by logistic regression to create a predictive model. The diagnostic performance of the model was calculated via receiver operating characteristics (ROC) analysis.Menopausal status, histological grade, nuclear grade, and four radiomics features demonstrated significant differences between the two TILs groups. Multivariable logistic regression revealed that nuclear grade and three radiomics features (Morphological COMShift, GLCM Correlation, and GLSZM Small Zone Emphasis) were independently associated with TIL grouping. The diagnostic performance analysis of the model showed an AUC of 0.864 (95% CI: 0.776-0.953; p < 0.001). The sensitivity, specificity, PPV, NPV and accuracy values of the model were 69.6%, 82.4%, 64%, 85.7% and 78.4%, respectivelyThe pathological TIL scores of BC patients can be predicted by using radiomics feature extraction from baseline 18F FDG PET/CT scans.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"194-204"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Field of View Matters: A Case of Incidental Lingual Thyroid Detection. 视野问题：偶然发现舌甲状腺1例。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2025-03-11 DOI: 10.1055/a-2535-1172

Michael C M Gammel, Kimberley Hansen, Wolfgang A Weber, Matthias Eiber, Isabel Rauscher

引用次数: 0

Activation of fibroblast in intestinal Behçet's disease shown by 68Ga-FAPI-04 PET/CT. 68Ga-FAPI-04 PET/CT显示肠behaperet病成纤维细胞的活化。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1055/a-2543-0982

Silu Liu, Qingqing Pan, Hui Xu, Yaping Luo

引用次数: 0

Correction: 18F-FDG PET/CT images of adult pulmonary blastoma: a case report. 更正：成人肺泡瘤的 18F-FDG PET/CT 图像：一份病例报告。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2024-02-20 DOI: 10.1055/a-2265-4049

Minhan Chen, Yao Liu

引用次数: 0

Importance of oxyphil cells for 99mTc-sestamibi uptake in primary hyperparathyroidism: a retrospective observational study. 原发性甲状旁腺功能亢进症患者嗜氧细胞对99m锝-sestamibi摄取的重要性：一项回顾性观察研究。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2025-03-06 DOI: 10.1055/a-2535-1067

Jan Axl Dropmann, Axel Kleespies, Heinrich Fuerst, Marcus Kremer, Moritz Drefs, Michael Neuberger

{"title":"Importance of oxyphil cells for 99mTc-sestamibi uptake in primary hyperparathyroidism: a retrospective observational study.","authors":"Jan Axl Dropmann, Axel Kleespies, Heinrich Fuerst, Marcus Kremer, Moritz Drefs, Michael Neuberger","doi":"10.1055/a-2535-1067","DOIUrl":"10.1055/a-2535-1067","url":null,"abstract":"In patients with primary hyperparathyroidism (pHPT), the importance of oxyphil cells for 99mTc-sestamibi uptake is uncertain.This retrospective observational study of pHPT patients evaluated independent associations between oxyphil cell content (OCC) and preoperative scintigraphic (SC) findings, using logistic regression analyses.We studied 76 patients with pHPT before and after operation. Preoperative SC was able to definitively identify abnormal parathyroid tissue in 47 patients (61.8%). The median relative OCC (postoperative histopathological examination) was 10% (IQR 0.25% - 40%) and the median absolute OCC was 0.09 cm3 (IQR 0.00 - 0.59 cm3). After adjustment for confounders, an iPTH concentration >200 pg/ml and increasing OCC was the only significant independent predictor of a definitively positive SC result (per category of relative OCC: adjusted odds ratio (aOR) 2.40, 95% confidence interval (CI) 1.02 - 5.65, p=0.045).In patients with pHPT, a higher OCC was associated with a significantly higher probability of a clearly positive SC finding.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"215-224"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The diagnostic performance of an [18F]FDG PET/CT algorithm for preoperative evaluation of extrahepatic cholangiocarcinoma: a retrospective study. [18F]FDG PET/CT算法在肝外胆管癌术前评估中的诊断价值：回顾性研究。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1055/a-2561-1179

Hui Yang, Yi Zhang, Zhiwei Guan, Can Li, Guanyun Wang, Hui Zhou, Ruimin Wang, Baixuan Xu

{"title":"The diagnostic performance of an [18F]FDG PET/CT algorithm for preoperative evaluation of extrahepatic cholangiocarcinoma: a retrospective study.","authors":"Hui Yang, Yi Zhang, Zhiwei Guan, Can Li, Guanyun Wang, Hui Zhou, Ruimin Wang, Baixuan Xu","doi":"10.1055/a-2561-1179","DOIUrl":"https://doi.org/10.1055/a-2561-1179","url":null,"abstract":"In this retrospective study, we evaluated the diagnostic value of [18F]FDG PET/CT in preoperative assessment of extrahepatic cholangiocarcinoma (ECC) and to develop a PET-based diagnostic algorithm for ECC.Patients with suspected ECC with biliary obstruction were included. Patients received [18F]FDG PET/CT scan and image analysis. FDG uptake was semi-quantified using the SUVmax of the suspected primary tumor, lymph nodes and metastatic lesions. Sex, age, tumor location, enhancement patterns and tumor size were analyzed using binary logistic regression for prediction of ECC on PET images.The study included 238 ECC patients and 42 patients with benign diseases. The lesion was located in the common bile duct in 67.50% patients and in the hilar region in 31.79% patients. [18F]FDG PET/CT scan showed a sensitivity of 70.6% and a specificity of 76.2% for the diagnosis of cholangiocarcinoma in patients with extrahepatic lesions, with a positive predictive value of 94.4% and a negative predictive value of 31.4% and an accuracy of 71.4%. Forced entry logistic regression analysis showed that age (OR 1.07, 95%CI, 1.03 to 1.10) and detection of ECC by [18F]FDG PET/CT scan (OR 6.15, 95% CI, 2.00 to 19.10) were predictors of ECC. A PET-based scoring algorithm had an AUC of 0.81 (95% CI, 0.75 to 0.88) and had a sensitivity of 61.3% and a specificity of 88.1% for ECC. The algorithm had a significantly better diagnostic performance than [18F]FDG PET/CT scan (Chi square test, P <0.001).The PET-based algorithm shows improved diagnostic performance for the detection of ECC and could facilitate early diagnosis and staging of ECC.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"64 3","pages":"205-214"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Theranostic Application of Somatostatin Receptor Peptides in a Rare Case of Familial Multicentric Paragangliomas. 生长抑素受体肽在罕见家族性多中心副神经节瘤中的成功应用。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1055/a-2561-1380

Akram Al-Ibraheem, Hasan Alalawi, Ula Al-Rasheed, Abeer Anabtawi, Ahmed Saad Abdlkadir

引用次数: 0

A Case of Male Breast Cancer Detected by Myocardial Perfusion Scintigraphy. 心肌灌注显像检测男性乳腺癌1例。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-06-01 Epub Date: 2025-03-12 DOI: 10.1055/a-2543-0846

Ahmet Eren Şen, Fatma Hicret Tekin, Mustafa Erol, Ülkünur Çimen Şen

引用次数: 0