Nuklearmedizin. Nuclear medicine最新文献

{"title":"Late post-treatment 131I SPECT/CT reveals additional lymph node metastasis of papillary thyroid carcinoma.","authors":"Erik Karaskiwiecz, Arba Syka, Felix M Mottaghy, Susanne Lütje","doi":"10.1055/a-2852-9891","DOIUrl":"https://doi.org/10.1055/a-2852-9891","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massive Functioning Hepatic Metastasis from Follicular Thyroid Carcinoma under Radioiodine Therapy.","authors":"John Volkenandt, Anne Popp, Claudia Brogsitter, Ralph Alexander Bundschuh","doi":"10.1055/a-2843-3860","DOIUrl":"https://doi.org/10.1055/a-2843-3860","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact assessment of [18F]FDG PET/CT in predicting EGFR gene mutation status in patients with lung adenocarcinoma using recovery coefficient-based correction of semi-quantitative and volume-based PET metrics.","authors":"Aleksei Leontev, Angelina Lokhova, Aleksandr Khalimon, Malika Khodzhibekova, Tatyana Lazutina, Gulnara Khamadeeva, Daria Khodakova, Irina Pylova, Vitaly Bobrov, Leila Atakishieva, Natalia Kadymova, Anastasia Nikiforuk, Bogdan Shvets, Nadezhda Volchenko, Viktoriya Surkova, Petr Shatalov, Andrey Kaprin","doi":"10.1055/a-2777-2278","DOIUrl":"https://doi.org/10.1055/a-2777-2278","url":null,"abstract":"<p><p>The aim of this study was to assess the impact of [¹⁸F]FDG PET/CT in predicting EGFR gene mutation status in patients with lung adenocarcinoma using recovery coefficient-based (RC-based) correction of semi-quantitative and volume-based PET metrics.A retrospective multi-center study included 63 patients diagnosed with lung adenocarcinoma who underwent [¹⁸F]FDG PET/CT. Acquisition was performed according to the EANM guidelines using two EARL-accredited PET/CT-systems. All patients were divided into an EGFR-mutant (n=30) and a wild-type (n=33) groups based on the results of molecular testing. Maximal diameter and CT volume of each primary tumor lesion were measured. [¹⁸F]FDG uptake was evaluated by measurement of semi-quantitative and volume-based PET metrics such as SUVmax, SUVpeak, MTV, and TLG. TLG was measured using PET segmentation method by 3D-Isocontour tool with a 41% of SUVmax threshold (TLG_41%) and a threshold adapted to the CT volume (TLG_CT). Additionally, TLR was calculated as the ratio of tumor SUVpeak to liver SUVmean. Acquisition data of the NEMA IEC Body Phantom Set NU2-2018 were applied for plotting the RC curves which were used for following RC-based correction of PET metrics.No significant difference in tumor lesion maximal diameter, CT volume, evaluated values of PET metrics before and after RC-based correction was found between the EGFR-mutant and wild-type groups (p > 0.05).Observed semi-quantitative and volume-based PET metrics obtained from [¹⁸F]FDG PET/CT have no significant value for predicting EGFR gene mutation status in patients with lung adenocarcinoma, regardless of whether RC-based correction is applied.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DGN procedural guideline for bone scintigraphy with SPECT and SPECT/CT in children and adolescents.","authors":"Julian M M Rogasch, Holger Amthauer, Regine Kluge, Roland Bares, Imke Schatka, Thomas Pfluger, Christiane Franzius","doi":"10.1055/a-2784-7659","DOIUrl":"https://doi.org/10.1055/a-2784-7659","url":null,"abstract":"<p><strong>Aim: </strong>To present the updated S1 guideline recommendations on bone scintigraphy, including SPECT and SPECT/CT, in children and adolescents, with a particular focus on its positioning relative to alternative imaging modalities and on optimization of radiation protection.</p><p><strong>Methods: </strong>Narrative literature review and evaluation of interdisciplinary national and international guidelines, combined with expert consensus within the German Society of Nuclear Medicine. Indications, dosimetry and CT protocols were revised based on EANM recommendations, ICRP Publication 128 and newly established diagnostic reference levels.</p><p><strong>Results: </strong>Compared with the 2015 version, the clinical indications were comprehensively re-evaluated and restructured, with explicit consideration particularly of MRI and FDG-PET/CT or PET/MRI. Potential drug interactions relevant to image interpretation are listed systematically. Radiation exposure data were updated according to ICRP 128. For SPECT/CT, detailed age- and diameter-adapted recommendations for low-dose CT dose reduction were formulated. In addition, the role of [¹⁸F]NaF PET as a potential alternative to conventional bone scintigraphy in childhood is described.</p><p><strong>Conclusions: </strong>The updated guideline refines and sharpens the indications for bone scintigraphy in the context of MRI and PET techniques and reinforces the use of radiation dose-optimized protocols. It supports nuclear medicine teams in evidence- and guideline-based imaging of paediatric skeletal disorders.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[18F]FDG PET/CT diagnosis and follow-up of arterial intimal sarcoma of the left atrium.","authors":"Tao-Tao Sun, Lin-Bo Zhu, Lei Jiang, En-Tao Liu","doi":"10.1055/a-2784-7275","DOIUrl":"https://doi.org/10.1055/a-2784-7275","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"65 2","pages":"93-96"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioactive Gold Isotopes in the Era of Theranostics: Medical Potential of ¹⁹⁸Au and ¹⁹⁹Au Radioisotopes.","authors":"Punita Bhardwaj, Guilhem Claude, Winfried Brenner, Sarah Spreckelmeyer","doi":"10.1055/a-2784-7716","DOIUrl":"10.1055/a-2784-7716","url":null,"abstract":"<p><p>Radioactive gold isotopes, particularly the element-matched theranostic pair ¹⁹⁸Au and ¹⁹⁹Au, hold significant promise for targeted radionuclide therapy and SPECT imaging. This review critically evaluates their medical potential by contextualizing historical development, nuclear properties, production physics, radiochemical separations, and contemporary radiopharmaceutical applications to identify pathways for clinical translation.We comprehensively surveyed literature on gold isotope decay characteristics, reactor and accelerator based production from Au, Pt, and Hg targets, purification strategies including ion-exchange chromatography, solid-phase extraction, polymer/zeolite adsorption, and liquid-liquid extraction, alongside reviewing a spectrum of ¹⁹⁸Au/¹⁹⁹Au radiotracers from small-molecule complexes to nanostructures and bioconjugates. ¹⁹⁸Au and ¹⁹⁹Au offer complementary β^- emissions for therapy and their γ photons are ideal for SPECT imaging, with scalable carrier-added production routes from ¹⁹⁷Au and non-carrier-added routes via enriched Pt/Hg. Robust separation techniques deliver radioactive gold with higher purity, enabling the production of diverse agents including but not limited to Au(III) Schiff-bases, phosphine/dithiocarbamate/NHC complexes, thioglucose derivatives, intrinsically doped nanoparticles (RGD-, bombesin-, HER2-targeted), and antibody conjugates.While radioactive gold research has progressed from colloidal ¹⁹⁸Au brachytherapy to modern small molecule based complexes, barriers persist in sustainable high-specific-activity production, target recycling, in vivo stability, and clinical validation. Nevertheless, gold's chemical and physical characteristics position ¹⁹⁸Au/¹⁹⁹Au as candidates for next-generation radio-theranostics.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"69-82"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear cardiology - Current status of the clinical application.","authors":"Oliver Lindner, Christian Goetz, Frank M Bengel, Axel Linke, Alexander Maier, Maria Papathanasiou, Sigmund Silber, Christoph Rischpler, Simon Greulich, Jan Bucerius","doi":"10.1055/a-2778-2169","DOIUrl":"10.1055/a-2778-2169","url":null,"abstract":"<p><p>This updated position paper from the German Society of Nuclear Medicine (DGN) and the German Cardiac Society (DGK) replaces the original statement from 2018. It gives an overview of the fields of application and the current value of nuclear cardiological imaging. The topics covered include chronic coronary syndrome, including viability diagnostics and the special value of positron emission tomography (PET), cardiomyopathies, cardiac sarcoidosis, amyloidosis, infectious endocarditis and inflammation of cardiac implants.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"52-59"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"177Lu-based radioligand therapy: A retrospective multicenter analysis to calculate the effective half-life and follow-up dose for the public.","authors":"Christian Schütze, Markus Borowski, Martin Freesmeyer, Robert Freudenberg, Heribert Hänscheid, Jens Kurth, Marc Rudi Linde, Lara-Christiane Militzer, Bernhard Sattler, Tabea Nikola Schmidt, Paul Soubiran, Mathias Steffner, Lars Stegger, Carsten Wanke, Christian Kühnel","doi":"10.1055/a-2784-7468","DOIUrl":"10.1055/a-2784-7468","url":null,"abstract":"<p><p>The study investigated routinely used radiopharmaceuticals containing lutetium-177 (¹⁷⁷Lu), providing reference values for their effective half-life (T_1/2,eff). So far, no guidelines regarding discharging this patients exist, are essential to ensure radiation protection of the public. This study contributes to the development of binding discharge criteria regarding ¹⁷⁷Lu therapies.This retrospective multicenter study comprised eight nuclear medicine departments. Two commercially available products and two in-house preparations were considered. Radiation measurement methods, in terms of measuring device, setup, and time points were reported, as well as dose rate measurements for T_1/2,eff calculation.The study includes 210 dose rate measurement sets with a mean administered activity of (7149 ± 522) MBq. When only measurements up to 48 h p.i. were taken into account the T_{1/2, eff} were shorter (Pluvicto 1.30 d, Lutathera 1.40 d, ihPSMA 1.45 d, ihRRT 1.97 d) compared to 168 h (1.60 d, 1.89 d, 2.10 d, and 2.85 d, respectively). Differences were statistically significant for all compounds except Lutathera. The 90^th percentile of the T_1/2,eff observed in late measurements (Pluvicto 2.0 d, Lutathera 3.0 d, ihPSMA 3.5 d, ihRRT 4.0 d) can be considered conservative values for discharge calculations.The T_1/2,eff of ¹⁷⁷Lu is considerably shorter than its T_1/2,phy, owing to the pharmacokinetics of the entire molecule. This highlights the need of considering biological clearance mechanisms into calculations of discharge times for patients treated with ¹⁷⁷Lu. If direct measurements are not feasible in clinical routine, reference values support inpatient planning while ensuring radiation protection.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"60-68"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146088594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difficult-to-interpret dopamine transporter SPECT with [123I]ioflupane in the diagnosis of parkinsonism.","authors":"Ivayla Ilieva Apostolova, Thomas Buddenkotte, Loren Jedid, Susanne Klutmann, Rickmer Braren, Philipp T Meyer, Ralph Buchert","doi":"10.1055/a-2784-7591","DOIUrl":"https://doi.org/10.1055/a-2784-7591","url":null,"abstract":"<p><p>To estimate (i) the rate of difficult-to-interpret cases in dopamine transporter (DAT)-SPECT with [¹²³I]ioflupane and (ii) the diagnostic accuracy of binary visual categorization in difficult-to-interpret DAT-SPECT.The study included 178 control subjects (49% females, 63.7±11.7y) and 178 sex- and age-matched patients with pre-screening clinical diagnosis of Parkinson's disease (PD) from the Parkinson's Progression Markers Initiative (PPMI). SPECT images reconstructed by the PPMI and a local method were visually interpreted twice by 2 independent readers with respect to Parkinson-like reduction of the striatal signal using the following 6-score: -3 = clearly reduced, -2 = probably reduced, -1 = more likely reduced than normal, 1 = more likely normal than reduced, 2 = probably normal, 3 = clearly normal. Cases with 6-score of -1 or 1 were considered \"difficult-to-interpret\", all other cases were considered \"conclusive\". To assess diagnostic accuracy relative to the clinical group label (control, PD), the 6-score was binarized using 0 as cutoff.The proportion of difficult-to-interpret cases ranged between 3.4% (95%-CI 1.5-5.2%) and 7.6% (4.8-10.3%) across readers and reconstruction methods. The proportion of cases misclassified by the binarized score ranged between 17.4% (1.9-32.9%) and 50.0% (25.5-74.5%) among the difficult-to-interpret cases, and between 5.1% (2.7-7.4%) and 6.4% (3.8-9.0%) among the conclusive cases.(i) the proportion of difficult-to-interpret cases in DAT-SPECT for the diagnosis of parkinsonism is not larger than 10%, (ii) the diagnostic accuracy of binary decisions is severely reduced in these cases. We therefore recommend reporting difficult-to-interpret cases as \"inconclusive\", unless in special situations.</p>","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"65 2","pages":"83-92"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral absent brown adipose tissue activity and diaphragmatic paralysis allowing precise delineation of lymphoma-associated nerve damage.","authors":"Asif Moin, Elif Yilmaz, Orhan K Öz, Steven P Rowe","doi":"10.1055/a-2821-8949","DOIUrl":"https://doi.org/10.1055/a-2821-8949","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}