Nuklearmedizin. Nuclear medicine最新文献_第2页

Correction: Digitalization of Nuclear Medicine in Germany - Status Quo 2024. 更正：德国核医学数字化-现状2024。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-05-20 DOI: 10.1055/a-2604-5823

Thomas Wendler, Julian Manuel Michael Rogasch, Moritz B Bastian, Wolfgang Burchert, Dirk Hellwig, Lena Kaiser, Philipp Lohmann, Florian Rosar, Benedikt Schemmer, Johannes Tran-Gia, Isabelle Miederer

引用次数: 0

[99mTc]Tc-PSMA SPECT/CT is a promising tool in the staging of renal cell carcinoma. [99mTc]Tc-PSMA SPECT/CT是一种很有前途的肾细胞癌分期工具。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-05-12 DOI: 10.1055/a-2578-7222

Marcel Baehr, Isabell Dietrich, Knut Liepe

引用次数: 0

The Status of Neuroimaging with SPECT and PET in Germany: Results from the 1st Survey on Nuclear Neuroimaging in Germany in 2023. 德国SPECT和PET神经成像的现状：德国2023年第一次核神经成像调查结果。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-15 DOI: 10.1055/a-2566-1487

Ralph Buchert, Alexander Drzezga, Mathias Schreckenberger, Karl Josef Langen, Philipp T Meyer

{"title":"The Status of Neuroimaging with SPECT and PET in Germany: Results from the 1st Survey on Nuclear Neuroimaging in Germany in 2023.","authors":"Ralph Buchert, Alexander Drzezga, Mathias Schreckenberger, Karl Josef Langen, Philipp T Meyer","doi":"10.1055/a-2566-1487","DOIUrl":"https://doi.org/10.1055/a-2566-1487","url":null,"abstract":"The advent of disease-modifying therapies for neurodegenerative diseases may result in a growing demand for nuclear neuroimaging procedures presenting opportunities but also challenges to the nuclear medicine community. Whether capacity and expertise in Germany are sufficient to meet an increasing demand for nuclear neuroimaging is under discussion. Against this background, the Neuroimaging Working Group of the German Society of Nuclear Medicine initiated the first survey on the status of nuclear neuroimaging in Germany in 2023. 82 institutions participated in the survey: 33 practices, 15 community hospitals, 34 university hospitals. Primary findings were the following. In practices, brain scans are less frequently performed than in hospitals and are often limited to dopamine transporter SPECT. Brain PET is mainly performed in hospitals, and in community hospitals it is often restricted to FDG PET. Nevertheless, availability of amyloid PET with well-certified quality can be taken for granted. Thus, access to amyloid PET will not be a major bottleneck for new treatments of Alzheimer's disease. Adequate reimbursement and clear anchoring in clinical guidelines have the greatest potential to advance nuclear neuroimaging in Germany. Clinical dopamine transporter SPECT is largely in agreement with procedure guidelines. An area for improvement is the limited availability of MR images to avoid misinterpretation of structural/vascular lesions as nigrostriatal degeneration. The survey provides the first systematic assessment of the status of nuclear neuroimaging in Germany. It underscores the capacity of the German nuclear medicine community to meet an increasing demand for neuroimaging procedures, its adherence to procedure guidelines and identifies topics for improvement.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of the xSPECT reconstruction algorithms on the recovery coefficients value for small tumors: a phantom study with 177Lu. xSPECT重建算法对小肿瘤恢复系数值的影响：177Lu的幻影研究。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-12-11 DOI: 10.1055/a-2418-2486

Ali Ebrahimifard, Hossein Rajabi, Parham Geramifar, Markus Luster, Behrooz Hooshyar Yousefi, Robin de Nijs

{"title":"The impact of the xSPECT reconstruction algorithms on the recovery coefficients value for small tumors: a phantom study with 177Lu.","authors":"Ali Ebrahimifard, Hossein Rajabi, Parham Geramifar, Markus Luster, Behrooz Hooshyar Yousefi, Robin de Nijs","doi":"10.1055/a-2418-2486","DOIUrl":"10.1055/a-2418-2486","url":null,"abstract":"Quantifying small tumors is still a challenge due to the partial volume effect (PVE). Although iterative reconstruction had promising results with a better recovery coefficient (RC), it suffers from the PVE. RC values typically depend on the reconstruction method, which may affect on 177Lu quantifying. In this study, we investigated the effect of different reconstruction methods on RC values for 177Lu SPECT/CT images.A water-filled cylindrical polymethylmethacrylate (PMMA) phantom without background radioactivity with two solid cylinders which represent the bone and soft tissue equivalent was used for SPECT/CT imaging. We placed syringes with different volumes containing 177Lu in the vicinity of the cylinders as tumors. The iterative reconstructions of xSPECT, xSPECT Bone, and Flash3D was performed on SPECT/CT images.The effect of the reconstruction algorithms on the RC values was determined by calculating the radioactivity concentration in volumes of interest which were drawn manually and by a threshold method.The xSPECT Bone reconstruction has shown an RC value of approximately 100%, while the other reconstructions typically show an RC value of 93%. The RC values for all the reconstructions were decreased for smaller tumors. The smallest tumor showed a minimum RC between 52% and 72% compared to the largest tumor.In this study, it was possible to obtain an RC value close to 100% when the xSPECT Bone reconstruction algorithm was used. The xSPECT results were slightly lower RC values compared to the Flash3D algorithm. In using standard RC curves for tumors close to the bone, special care has to be taken since RC values relative to bone are higher than in tissue.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"132-140"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Thoracic SMARCA4-Deficient Undifferentiated Tumor on 18F-FDG PET/CT. 一例胸腔 SMARCA4 缺失型未分化肿瘤（18F-FDG PET/CT）。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-11-20 DOI: 10.1055/a-2383-2527

Gege Zhao, Zhongke Huang

引用次数: 0

Digitalization of Nuclear Medicine in Germany - Status Quo 2024. 德国核医学数字化-现状2024。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2025-04-17 DOI: 10.1055/a-2502-1728

Thomas Wendler, Julian Manuel Michael Rogasch, Moritz B Bastian, Wolfgang Burchert, Dirk Hellwig, Lena Kaiser, Philipp Lohmann, Florian Rosar, Benedikt Schemmer, Johannes Tran-Gia, Isabelle Miederer

{"title":"Digitalization of Nuclear Medicine in Germany - Status Quo 2024.","authors":"Thomas Wendler, Julian Manuel Michael Rogasch, Moritz B Bastian, Wolfgang Burchert, Dirk Hellwig, Lena Kaiser, Philipp Lohmann, Florian Rosar, Benedikt Schemmer, Johannes Tran-Gia, Isabelle Miederer","doi":"10.1055/a-2502-1728","DOIUrl":"10.1055/a-2502-1728","url":null,"abstract":"Digitalization in the healthcare sector is becoming increasingly widespread. Yet, the degree of digitalization in nuclear medicine has not been systematically investigated. The \"Digitalization and AI\" working group of the German Society of Nuclear Medicine conducted a survey to assess the status quo of digitalization of the nuclear medicine health infrastructure in Germany.100 questions were defined on eleven topics covering the main work processes in nuclear medicine. The survey primarily included single-select multiple-choice questions, yes-no questions on the availability of specific digital structures and processes, and questions assessing the degree of digitalization of certain processes and current satisfaction. The level of satisfaction was measured with an ordinal scale (1, very good to 5, poor).In most subject areas, processes relied on a combination of paper-based and electronic procedures for the topics analyzed. Differences in satisfaction regarding the different types of processes for any of the questions were not observed, and the overall level of satisfaction among responding sites was quite high.The survey did not reveal a clear need of the responding sites for complete digitalization of clinical processes. Yet, the participants highlighted the lack of proper Wi-Fi (60%) and the desire for a platform for communication between hospitals, registered doctors and patients (74%). Nevertheless, it is important to take a focused and unbiased look at the daily clinical procedures in every institution and place it in the frame of the existing tools or solutions of peer institutions to discover aspects of digitalization that can create added value in terms of time efficiency, integrity and sustainability.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"64 2","pages":"156-162"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic Neuroendocrine Tumor incidentally found on 68Ga-PSMA PET/CT. 68Ga-PSMA PET/CT偶然发现胰腺神经内分泌肿瘤。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2025-04-17 DOI: 10.1055/a-2511-6595

Rodrigo Luna, Daniel A Laheru, Eun Ji Shin, Chen Lossos, Mahalia T Robinson, Steven P Rowe, Elie Saad, Mark C Markowski

引用次数: 0

Comparison of whole-body 18F-FDG-PET/CT with 18F-FDG-PET/CT limited to skull base to upper abdomen for primary staging of lung cancer - a retrospective explorative analysis. 全身18F-FDG-PET/CT与局限于颅底至上腹的18F-FDG-PET/CT在肺癌初诊分期中的比较--一项回顾性探索分析。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-11-11 DOI: 10.1055/a-2438-7278

Lukas Schulz, Georg-Christian Funk, Klaus Kirchbacher, Elena Egger, Nino Müser, Siroos Mirzaei

{"title":"Comparison of whole-body 18F-FDG-PET/CT with 18F-FDG-PET/CT limited to skull base to upper abdomen for primary staging of lung cancer - a retrospective explorative analysis.","authors":"Lukas Schulz, Georg-Christian Funk, Klaus Kirchbacher, Elena Egger, Nino Müser, Siroos Mirzaei","doi":"10.1055/a-2438-7278","DOIUrl":"10.1055/a-2438-7278","url":null,"abstract":"The gold standard for ruling out distant metastases as part of primary staging in lung cancer is whole-body 18F-FDG-PET/CT, but this method is resource-intensive. Recent evidence suggests that examining only the thorax and upper abdomen may be sufficient 1 2 3. If a limited 18F-FDG-PET/CT approach proves effective for proper staging, it could lead to quicker examinations and reduced radiation exposure. This study aimed to determine whether limited 18F-FDG-PET/CT is adequate for the primary staging of lung cancer.In this study, a retrospective analysis of 161 patients (87 men, 74 women; age range 31-88 y) with recent or suspected lung cancer who had undergone a whole-body 18F-FDG-PET/CT examination for primary staging at our clinic between 2018 and 2022 was conducted. None of these patients showed evidence of extrathoracic metastases before the 18F-FDG-PET/CT examination. The images were divided into three regions: \"head-neck\" (HN), \"thorax-upper abdomen\" (TUA), and \"lower abdomen-hip\" (LAH). TNM staging based on the HN plus TUA region was compared with TNM staging based on the whole body.Among the 161 subjects, 7 (4%) showed malignancy-suspect lesions in HN, 110 (68%) in TUA and 7 (4%) had suspected distant metastases in LAH. The TNM staging based on HN plus TUA corresponded to TNM staging based on the whole body in 161 (100%) examinations. This finding aligns with similar results in previous literature. 18F-FDG-PET/CT limited to HN and TUA yielded accurate staging in all cases. Adopting this method could facilitate the examination and correct staging of more individuals, reducing exam waiting times and physician reporting time and minimising radiation exposure.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"150-155"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intratumoral distribution and pharmacokinetics of the radiolabeled ICAM-1 targeting monoclonal antibody R6.5 in a prostate cancer mouse model. 放射标记ICAM-1靶向单克隆抗体R6.5在前列腺癌小鼠模型中的瘤内分布和药代动力学

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI: 10.1055/a-2543-0723

Anders Örbom, Susan Evans-Axelsson, Bo Jansson, Oskar Vilhelmsson Timmermand, Thuy A Tran, Anders Bjartell, Sven-Erik Strand

{"title":"Intratumoral distribution and pharmacokinetics of the radiolabeled ICAM-1 targeting monoclonal antibody R6.5 in a prostate cancer mouse model.","authors":"Anders Örbom, Susan Evans-Axelsson, Bo Jansson, Oskar Vilhelmsson Timmermand, Thuy A Tran, Anders Bjartell, Sven-Erik Strand","doi":"10.1055/a-2543-0723","DOIUrl":"10.1055/a-2543-0723","url":null,"abstract":"Despite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.Anti-ICAM-1 antibody R6.5 was labeled with 111In or 177Lu, and a non-specific antibody with 177Lu. In vitro uptake of R6.5 was tested in PC-3 prostate cancer cells. Biodistribution studies, SPECT/CT imaging, and autoradiography were performed in a PC-3 xenograft model.In vitro uptake of R6.5 ([177Lu]Lu-R6.5) increased during 6 h of incubation. The uptake was higher at lower mAb concentration and could be blocked by 500 nM of unlabeled R6.5. In vivo and ex vivo biodistribution showed that [111In]In-R6.5 and [177Lu]Lu-R6.5 targeted the xenograft tumors better than the control Ab, however [111In]In-R6.5 had better tumor uptake than [177Lu]Lu-R6.5, probably due to less aggressive conjugation with chelator and smaller tumor sizes. From 24 h post-injection, the tumors in mice injected with [111In]In-R6.5 and [177Lu]Lu-R6.5 were visible on SPECT, optimal contrast at 48 h. Uptake was low in normal organs except the spleen and liver for all mAbs. Autoradiography showed [111In]In-R6.5 and [177Lu]Lu-R6.5 accumulated along the edges of viable tumor. The control Ab tended to accumulate in partly necrotic areas.This study demonstrates ICAM-1 as a potential target for theragnostics in CRPC.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":" ","pages":"163-169"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A metastatic melanoma with an atypical low 18F-FDG uptake. 转移性黑色素瘤，不典型低18F-FDG摄取。

Nuklearmedizin. Nuclear medicine Pub Date : 2025-04-01 Epub Date: 2024-12-04 DOI: 10.1055/a-2383-2584

Laura Ternoy, Pierre Meneret, Xavier Palard-Novello, David Russo

引用次数: 0