Carbohydrate Research最新文献_第7页

Photocatalyst-free light-promoted carbohydrate synthesis and modification 无光催化剂光促进碳水化合物合成和改性。

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-11-05 DOI: 10.1016/j.carres.2024.109304

Jing Wang , Fan Zhou , Yuping Xu , Lei Zhang

引用次数: 0

Entropy-enthalpy compensation in the methyl 5-thio-α-d-galactopyranoside–Jacalin interaction 5-thio-α-d-galactopyranoside-Jacalin 与甲基 5-thio-α-d-galactopyranoside 的相互作用中的熵焓补偿。

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-11-05 DOI: 10.1016/j.carres.2024.109305

Daniil Ahiadorme , David Crich

引用次数: 0

Structure analysis and immunomodulatory activity of novel oligosaccharide from Nicotiana tabacum roots 来自烟草根的新型寡糖的结构分析和免疫调节活性。

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-11-01 DOI: 10.1016/j.carres.2024.109303

Ming Ma , Fengdie Yan , Jing Jing , Kunyan Chen , Peng Wang , Changguo Wang , Qianfeng Chen

引用次数: 0

Synthetic strategy for polyhydroxylated indolizidine iminosugar from sugar-derived HWE precursor 从糖源 HWE 前体合成多羟基吲嗪亚氨基糖的策略

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-11-01 DOI: 10.1016/j.carres.2024.109302

Nagaraja Ingaladal , Ravi S. Lankalapalli

引用次数: 0

Effect of bacterial dissociation on lipopolysaccharide structure: A study of O-polysaccharide from the marine bacterium Pseudoalteromonas agarivorans KMM 232 (O-form) 细菌解离对脂多糖结构的影响：对海洋细菌 Pseudoalteromonas agarivorans KMM 232（O-form）O 型多糖的研究。

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-11-01 DOI: 10.1016/j.carres.2024.109300

Maxim S. Kokoulin , Vlada S. Belova , Lyudmila A. Romanenko

引用次数: 0

Sustainable production of organic acids from chitin biomass catalyzed by Keggin-type heteropolyacid under hydrothermal condition 水热条件下 Keggin 型杂多酸催化甲壳素生物质可持续生产有机酸。

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-11-01 DOI: 10.1016/j.carres.2024.109299

Yulong Chang, Yongtai Wang, Yimo Feng, Xiangling Zhu, Hongjun Zang

引用次数: 0

Modeling conformational changes in alginic acid oligomers induced by external forces 模拟藻酸低聚物在外力作用下的构象变化。

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-11-01 DOI: 10.1016/j.carres.2024.109294

Agnieszka Brzyska , Wojciech Płaziński

{"title":"Modeling conformational changes in alginic acid oligomers induced by external forces","authors":"Agnieszka Brzyska , Wojciech Płaziński","doi":"10.1016/j.carres.2024.109294","DOIUrl":"10.1016/j.carres.2024.109294","url":null,"abstract":"<div><div>In this study, the mechanism and nature of mechanical force-induced conformational transitions of alginate oligomers with different ratios of β-<span>d</span>-mannuronic acid (M unit) and α-<span>l</span>-guluronic acid (G unit) units were investigated. The influence of the type of glycosidic linkage in either homo- or heterooligomers on the nature of conformational transitions was also considered. For this purpose, two different theoretical methods were used: quantum mechanics (QM) at the DFT level with the EGO (Enforced Geometry Optimization) approach previously tested also for other saccharide systems, and molecular dynamics (MD) simulations within hybrid interaction potentials, which take into account both the ab initio (QM) level of theory and classical molecular mechanics (MM) force fields. This allowed to characterize in detail the structural and energetic properties of the conformational transition occurring upon the influence of external, mechanical forces (e.g. ring conformations at the path of ring-inversion process as well as the energies corresponding to initial, final and intermediate states). The results indicate qualitatively various responses against the applied force, depending on the G:M ratio, which have their source in differing topologies of glycosidic linkage in either G or M units. This is of potential relevance for determining the content of naturally heterogeneous alginate chains by the AFM experimental studies. The effects of explicit solvent and non-zero temperature are not of primarily importance in the context of determined stretching properties.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"545 ","pages":"Article 109294"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bile acid conjugated chitosan nanoparticles promote the proliferation and epithelial-mesenchymal transition of hepatocellular carcinoma by regulating the PI3K/Akt/mTOR pathway 胆汁酸共轭壳聚糖纳米粒子通过调节 PI3K/Akt/mTOR 通路促进肝细胞癌的增殖和上皮-间质转化。

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-11-01 DOI: 10.1016/j.carres.2024.109296

Ziyu Jiang , Yi Xu , Liu Yang , Xing Huang , Jun Bao

{"title":"Bile acid conjugated chitosan nanoparticles promote the proliferation and epithelial-mesenchymal transition of hepatocellular carcinoma by regulating the PI3K/Akt/mTOR pathway","authors":"Ziyu Jiang , Yi Xu , Liu Yang , Xing Huang , Jun Bao","doi":"10.1016/j.carres.2024.109296","DOIUrl":"10.1016/j.carres.2024.109296","url":null,"abstract":"<div><div>Bile acids have been known to play significant roles at certain physiological levels in gastrointestinal metabolism. Yet, they are known to be carcinogenic and aid in tumor progression in most cases, although the roles remain uncertain. Hence, we tested the cytotoxic potential of cholic acid (CA) loaded chitosan nanoparticles (CNPs) on Hep3B cells. The physicochemical properties of the CNPs synthesized with CA load (CA-CNPs) were determined using standard techniques such as ultraviolet–visible spectrophotometry (UV–Vis), fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The characteristic peak for chitosan nanoparticles were observed for plain CNPs (pCNPs) and CA-CNPs at around 300 nm as per UV–Vis analysis. FTIR analysis indicated the possible trapping of CA onto CNPs as certain peaks were retained and some peaks were shifted. XRD analysis determined that the peaks representing CA and pCNPs were collectively obtained in CA-CNPs. As per DLS analysis, the particle size, PDI and ζ-potential of the CA-CNPs were 259 nm, 0.284 and 30.4 mV. Further, the CA-CNPs were non-cytotoxic on Hep3B cells at the maximum tested concentration of 500 μg/mL. The viability at 500 μg/mL of CA-CNPs was two-fold higher than 500 μg/mL of pCNPs. Also, the pCNPs were not hemolytic and therefore could not have played a role in the increase of viability after treatment with CA-CNPs, which indicates that CA posed a major role in increased viability of Hep3B cells. As per quantitative PCR (qPCR), the upregulated gene expressions of PI3K, Akt, mTORC2, cMyc, Fibronectin, hVPS34, Slug and ZEB1 and the downregulated expression of the tumor suppressor PTEN indicates that PI3K/Akt/mTOR pathway mediated the induction of epithelial-to-mesenchymal transition (EMT) in response to CA-CNPs treatment on Hep3B cells.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"545 ","pages":"Article 109296"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan-curcumin conjugate prepared by one-step free radical grafting: Characterization, and functional evaluation 一步自由基接枝法制备壳聚糖-姜黄素共轭物：表征和功能评估

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-10-23 DOI: 10.1016/j.carres.2024.109297

Xuerong Luo , Lingyu Zhao , Imran Mahmood Khan , Lin Yue , Yin Zhang , Zhouping Wang

{"title":"Chitosan-curcumin conjugate prepared by one-step free radical grafting: Characterization, and functional evaluation","authors":"Xuerong Luo , Lingyu Zhao , Imran Mahmood Khan , Lin Yue , Yin Zhang , Zhouping Wang","doi":"10.1016/j.carres.2024.109297","DOIUrl":"10.1016/j.carres.2024.109297","url":null,"abstract":"<div><div>Curcumin (Cur) is a naturally hydrophobic polyphenol, and it has a wide range of physiological functions. But the practical application of Cur is constrained by its low water solubility and poor stability. To improve these deficiencies of Cur, a novel Cur derivative (CS-Cur) was prepared by grafting chitosan (CS) with Cur through a one-step reaction of a free radical-mediated redox system. A series of characterizations provided evidence that the grafting of CS with Cur was successful. The obtained CS-Cur showed lower crystallinity and thermal properties than CS and Cur. After grafting, the water solubility of CS-Cur was found to be 9.76 ± 2.45 g/L and greatly improved. Meanwhile, the CS-Cur showed good photothermal stability, antioxidant activity, and photodynamic antibacterial activity in an aqueous solution, and it had good <em>in vitro</em> biosafety. This provides an idea for the design and synthesis of novel highly water-soluble Cur derivatives and also improves the practical application of Cur in aqueous systems.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"545 ","pages":"Article 109297"},"PeriodicalIF":2.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the therapeutic potential of polysaccharide from Portulaca oleracea L.: A review of phytochemistry and immunomodulatory effect 探索马齿苋多糖的治疗潜力：植物化学和免疫调节作用综述

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-10-23 DOI: 10.1016/j.carres.2024.109298

Hai-Xin Liu , Ling-Ling Ding , Yan-Yan Chen , Shi-Yuan Wen

{"title":"Exploring the therapeutic potential of polysaccharide from Portulaca oleracea L.: A review of phytochemistry and immunomodulatory effect","authors":"Hai-Xin Liu , Ling-Ling Ding , Yan-Yan Chen , Shi-Yuan Wen","doi":"10.1016/j.carres.2024.109298","DOIUrl":"10.1016/j.carres.2024.109298","url":null,"abstract":"<div><div><em>Portulaca oleracea</em> L., a plant with both edible and medicinal properties, is traditionally valued for its diuretic, antipyretic, antiseptic, antispasmodic, and anthelmintic functions in folk medicine. <em>P</em>. <em>oleracea</em> polysaccharide (POP), a pivotal bioactive component, has various biological activities. Notably, their immunomodulatory capabilities have emerged as a significant area of research. The extraction, purification, monosaccharide composition, structure characterization, and biological activity of POP have been extensively investigated to identify the active components and to clarify their pharmacological actions and underlying molecular mechanisms. It aims to delineate the pharmacological mechanisms and molecular pathways associated with these polysaccharides, thereby underscoring their therapeutic promise and nutritional significance. Furthermore, the review critically examines the current research landscape of POP, identifying gaps and proposing innovative perspectives to enrich the scientific discourse surrounding these bioactive compounds.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"545 ","pages":"Article 109298"},"PeriodicalIF":2.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0