Carbohydrate Research最新文献_第7页

Mechanism and application of bacterial exopolysaccharides: An advanced approach for sustainable heavy metal abolition from soil 细菌外多糖的机制和应用：可持续去除土壤中重金属的先进方法

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-08-22 DOI: 10.1016/j.carres.2024.109247

Ankita Ghosh, Diksha Sah, Moumita Chakraborty, J.P.N. Rai

{"title":"Mechanism and application of bacterial exopolysaccharides: An advanced approach for sustainable heavy metal abolition from soil","authors":"Ankita Ghosh, Diksha Sah, Moumita Chakraborty, J.P.N. Rai","doi":"10.1016/j.carres.2024.109247","DOIUrl":"10.1016/j.carres.2024.109247","url":null,"abstract":"<div>The escalation of heavy metal pollutants in soils and effluents, driven by industrialization and human activities, poses significant environmental and health risks. Conventional remediation methods are often costly and ineffective, prompting a shift towards sustainable alternatives such as biological treatments. Natural biosorbents, including microbial cells and their byproducts, have emerged as promising solutions. One such approach involves leveraging exopolysaccharides (EPS), complex high-molecular-weight biopolymers synthesized by microbes under environmental stress conditions. EPS are intricate organic macromolecules comprising proteins, polysaccharides, uronic acids, humic compounds, and lipids, either located within microbial cells or secreted into their surroundings. Their anionic functional groups enable efficient electrostatic binding of cationic heavy metals, making EPS effective biosorbents for soil remediation. This review thoroughly explores the pivotal role of bacterial EPS in the removal of heavy metals, focusing on EPS biosynthesis mechanisms, the dynamics of interaction with heavy metals, and case studies that illustrate their effectiveness in practical remediation strategies. By highlighting these aspects, the review underscores the innovation and practical implications of EPS-based bioremediation technologies, demonstrating their potential to address critical environmental challenges effectively while paving the way for sustainable environmental management practices. Key findings reveal that EPS exhibit robust metal-binding capacities, facilitated by their anionic functional groups, thereby offering a promising solution for mitigating metal pollution in diverse environmental matrices.</div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"544 ","pages":"Article 109247"},"PeriodicalIF":2.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease” "训练有素的免疫中的糖：稳态和疾病中先天免疫记忆的教育者"

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-08-20 DOI: 10.1016/j.carres.2024.109245

Pedro Almeida , Ângela Fernandes , Inês Alves , Salomé S. Pinho

{"title":"“Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease”","authors":"Pedro Almeida , Ângela Fernandes , Inês Alves , Salomé S. Pinho","doi":"10.1016/j.carres.2024.109245","DOIUrl":"10.1016/j.carres.2024.109245","url":null,"abstract":"<div>Trained Immunity is defined as a biological process normally induced by exogenous or endogenous insults that triggers epigenetic and metabolic reprogramming events associated with long-term adaptation of innate immune cells. This trained phenotype confers enhanced responsiveness to subsequent triggers, resulting in an innate immune “memory” effect. Trained Immunity, in the past decade, has revealed important benefits for host defense and homeostasis, but can also induce potentially harmful outcomes associated with chronic inflammatory disorders or autoimmune diseases. Interestingly, evidence suggest that the “trainers” prompting trained immunity are frequently glycans structures. In fact, the exposure of different types of glycans at the surface of pathogens is a key driver of the training phenotype, leading to the reprogramming of innate immune cells through the recognition of those glycan-triggers by a variety of glycan-binding proteins (GBPs) expressed by the immune cells. β-glucan or mannose-enriched structures in Candida albicans are some of the examples that highlight the potential of glycans in trained immunity, both in homeostasis and in disease. In this review, we will discuss the relevance of glycans exposed by pathogens in establishing key immunological hubs with glycan-recognizing receptors expressed in immune cells, highlighting how this glycan-GBP network can impact trained immunity. Finally, we discuss the power of glycans and GBPs as potential targets in trained immunity, envisioning potential therapeutic applications.</div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"544 ","pages":"Article 109245"},"PeriodicalIF":2.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0008621524002246/pdfft?md5=6a05b42c9d784aad7e27368d88487846&pid=1-s2.0-S0008621524002246-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Punica granatum L. polysaccharides: A review on extraction, structural characteristics and bioactivities 石榴多糖：提取、结构特征和生物活性综述

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-08-20 DOI: 10.1016/j.carres.2024.109246

Bin Zhao , Chunying Zhang , Tianshi Guo , Yan Wei

{"title":"Punica granatum L. polysaccharides: A review on extraction, structural characteristics and bioactivities","authors":"Bin Zhao , Chunying Zhang , Tianshi Guo , Yan Wei","doi":"10.1016/j.carres.2024.109246","DOIUrl":"10.1016/j.carres.2024.109246","url":null,"abstract":"<div>Punica granatum L., commonly known as pomegranate, is native to Afghanistan and Iran, and today widely cultivated all over the world. Pomegranate polysaccharides are one of the most important bioactive components of P. granatum, which have a wide range of beneficial biological activities, such as anticancer, immunostimulatory, hepatoprotection, anti-psoriasis and antioxidation. Hot water extraction is currently the most commonly used method to isolate pomegranate polysaccharides. The structural characteristics of pomegranate polysaccharides have been extensively investigated through various advanced modern analytical techniques. This review focuses on the extraction, purification, structural characteristics, biological activities and structure-activity relationships of polysaccharides from Punica granatum. The aim of this article is to comprehensively and systematically summarize recent information of polysaccharides from Punica granatum and to serve as a basis for further research and development as therapeutic agents and functional foods.</div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"544 ","pages":"Article 109246"},"PeriodicalIF":2.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142040000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sugar functionalized coumarin motifs: Synthesis and applications 糖功能化香豆素基团：合成与应用

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-08-18 DOI: 10.1016/j.carres.2024.109244

Shubhi Dwivedi, Soumyadip Dey, Abhijit Sau

引用次数: 0

Synthesis, characterization and antifungal activity of imidazole chitosan derivatives 咪唑壳聚糖衍生物的合成、表征和抗真菌活性

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-08-15 DOI: 10.1016/j.carres.2024.109238

Lulu Wu, Liangxin Fan, Lijun Shi, Caixia Wang, Zhenliang Pan, Cuilian Xu, Guoyu Yang

{"title":"Synthesis, characterization and antifungal activity of imidazole chitosan derivatives","authors":"Lulu Wu, Liangxin Fan, Lijun Shi, Caixia Wang, Zhenliang Pan, Cuilian Xu, Guoyu Yang","doi":"10.1016/j.carres.2024.109238","DOIUrl":"10.1016/j.carres.2024.109238","url":null,"abstract":"<div>Five novel imidazole-functionalized chitosan derivatives 3a-3e were synthesized via addition reactions of chitosan with imidazole derivatives. The partial incorporation of imidazole moiety in chitosan were confirmed by FTIR, UV, 1H NMR, XRD, SEM and GPC. Meanwhile, the antifungal activity against three common plant pathogenic fungi: Phytophthora nicotianae (P. nicotianae), Fusarium graminearum (F. graminearum) and Rhizoctonia solani (R. solani), was assayed in vitro at 0.5 and 1.0 mg/mL by hyphal measurement, and the introduction of imidazole group can influence the antifungal activity. At 0.5 mg/mL, 3e inhibited P. nicotianae growth by 42 % and had an inhibitory index against R. solani of 50 %. Derivative 3e was more effective than unmodified chitosan whose antifungal index was 17 % against P. nicotianae and 22 % against R. solani. To our surprise, at 1.0 mg/mL, the inhibition rate of 3e against R. solani can reach 99 %, while the inhibition rate of chitosan is only 38 %. These results indicated that some imidazole chitosan derivatives with enhanced antifungal activities could serve as potential biomaterial for antifungal application.</div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"544 ","pages":"Article 109238"},"PeriodicalIF":2.4,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production of unsulfated chondroitin and associated chondro-oligosaccharides in recombinant Escherichia coli 在重组大肠杆菌中生产未硫酸化的软骨素和相关软骨寡糖

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-08-14 DOI: 10.1016/j.carres.2024.109243

Yanna André , Emeline Richard , Mélanie Leroux , Isabelle Jeacomine , Eric Bayma , Sylvie Armand , Bernard Priem

{"title":"Production of unsulfated chondroitin and associated chondro-oligosaccharides in recombinant Escherichia coli","authors":"Yanna André , Emeline Richard , Mélanie Leroux , Isabelle Jeacomine , Eric Bayma , Sylvie Armand , Bernard Priem","doi":"10.1016/j.carres.2024.109243","DOIUrl":"10.1016/j.carres.2024.109243","url":null,"abstract":"<div>We designed metabolically engineered non-pathogenic strains of Escherichia coli to produce unsulfated chondroitin with and without chondroitin lyase to produce the chondroitin polymer or its related oligosaccharides. Chondroitin was synthesized using chondroitin synthase KfoC and chondroitin was degraded using Pl35, a chondroitin lyase from Pedobacter heparinus. Pl35 behaved as a true endo-enzyme generating a large panel of oligosaccharides ranging from trimers to 18-mers instead of the di- and tetramers obtained with most chondroitin lyases. Two series of oligosaccharides were characterized, sharing an unsaturated uronic acid (4-deoxy-α-L-threo-hex-4-enepyranosyluronic acid, △UA) residue at their non-reducing end. The major “even-numbered” series was characterized by a terminal reducing N-acetylgalactosaminyl residue. The minor “odd-numbered” series oligosaccharides carried a terminal reducing glucuronic acid residue instead.Cultures were conducted in fed-batch conditions, and led to the production of up to 10 g L−1 chondroitin or chondroitin oligosaccharides.All products were purified and fully characterized using NMR and mass spectrometry analyses.This is the first report of the microbial production of large chondro-oligosaccharides.</div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"544 ","pages":"Article 109243"},"PeriodicalIF":2.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0008621524002222/pdfft?md5=72d24042146c3bbaed29a40488635760&pid=1-s2.0-S0008621524002222-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting legume lectins: Structural organization and carbohydrate-binding properties 重新审视豆科凝集素：结构组织和碳水化合物结合特性

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-08-13 DOI: 10.1016/j.carres.2024.109241

Vinicius J.S. Osterne, Gilles De Sloover, Els J.M. Van Damme

{"title":"Revisiting legume lectins: Structural organization and carbohydrate-binding properties","authors":"Vinicius J.S. Osterne, Gilles De Sloover, Els J.M. Van Damme","doi":"10.1016/j.carres.2024.109241","DOIUrl":"10.1016/j.carres.2024.109241","url":null,"abstract":"<div>Legume lectins are a diverse family of carbohydrate-binding proteins that share significant similarities in their primary, secondary, and tertiary structures, yet exhibit remarkable variability in their quaternary structures and carbohydrate-binding specificities. The tertiary structure of legume lectins, characterized by a conserved β-sandwich fold, provides the scaffold for the formation of a carbohydrate-recognition domain (CRD) responsible for ligand binding. The structural basis for the binding is similar between members of the family, with key residues interacting with the sugar through hydrogen bonds, hydrophobic interactions, and van der Waals forces. Variability in substructures and residues within the CRD are responsible for the large array of specificities and enable legume lectins to recognize diverse sugar structures, while maintaining a consistent structural fold. Therefore, legume lectins can be classified into several specificity groups based on their preferred ligands, including mannose/glucose-specific, N-acetyl-d-galactosamine/galactose-specific, N-acetyl-d-glucosamine-specific, l-fucose-specific, and α-2,3 sialic acid-specific lectins. In this context, this review examined the structural aspects and carbohydrate-binding properties of representative legume lectins and their specific ligands in detail. Understanding the structure/binding relationships of lectins continues to provide valuable insights into their biological roles, while also assisting in the potential applications of these proteins in glycobiology, diagnostics, and therapeutics.</div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"544 ","pages":"Article 109241"},"PeriodicalIF":2.4,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141993583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Putting a cap on the glycome: Dissecting human sialyltransferase functions 为糖分子结构戴上帽子剖析人类糖基转移酶的功能

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-08-13 DOI: 10.1016/j.carres.2024.109242

Khadra A. Mohamed, Stijn Kruf, Christian Büll

{"title":"Putting a cap on the glycome: Dissecting human sialyltransferase functions","authors":"Khadra A. Mohamed, Stijn Kruf, Christian Büll","doi":"10.1016/j.carres.2024.109242","DOIUrl":"10.1016/j.carres.2024.109242","url":null,"abstract":"<div>Human glycans are capped with sialic acids and these nine-carbon sugars mediate many of the biological functions and interactions of glycans. Structurally diverse sialic acid caps mark human cells as self and they form the ligands for the Siglec immune receptors and other glycan-binding proteins. Sialic acids enable host interactions with the human microbiome and many human pathogens utilize sialic acids to infect host cells. Alterations in sialic acid-carrying glycans, sialoglycans, can be found in every major human disease including inflammatory conditions and cancer. Twenty sialyltransferase family members in the Golgi apparatus of human cells transfer sialic acids to distinct glycans and glycoconjugates. Sialyltransferases catalyze specific reactions to form unique sialoglycans or they have shared functions where multiple family members generate the same sialoglycan product. Moreover, some sialyltransferases compete for the same glycan substrate, but create different sialic acid caps. The redundant and competing functions make it difficult to understand the individual roles of the human sialyltransferases in biology and to reveal the specific contributions to pathobiological processes. Recent insights hint towards the existence of biosynthetic rules formed by the individual functions of sialyltransferases, their interactions, and cues from the local Golgi environment that coordinate sialoglycan biosynthesis. In this review, we discuss the current structural and functional understanding of the human sialyltransferase family and we review recent technological advances that enable the dissection of individual sialyltransferase activities.</div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"544 ","pages":"Article 109242"},"PeriodicalIF":2.4,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0008621524002210/pdfft?md5=985723e9a3c09c761079e34a6e7c5486&pid=1-s2.0-S0008621524002210-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A concise synthetic approach for isoiminosugars 异亚氨基糖的简明合成方法

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-08-10 DOI: 10.1016/j.carres.2024.109239

Martin Thonhofer , André Culum , Tobias Dorn , Roland Fischer , Herwig Prasch , Arnold E. Stütz , Patrick Weber , Tanja M. Wrodnigg

引用次数: 0

A review of Lycium barbarum polysaccharides: Extraction, purification, structural-property relationships, and bioactive molecular mechanisms 枸杞多糖综述：枸杞多糖的提取、纯化、结构-性质关系和生物活性分子机制。

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2024-08-09 DOI: 10.1016/j.carres.2024.109230

Jiao Wang , Shifeng Li , Hua Zhang , Xin Zhang

{"title":"A review of Lycium barbarum polysaccharides: Extraction, purification, structural-property relationships, and bioactive molecular mechanisms","authors":"Jiao Wang , Shifeng Li , Hua Zhang , Xin Zhang","doi":"10.1016/j.carres.2024.109230","DOIUrl":"10.1016/j.carres.2024.109230","url":null,"abstract":"<div>Lycium barbarum L. is of great significance medicinal and edible plant, which is native to N. & Central China. The extensive health benefits of L. barbarum have earned it great respect in traditional medicine for centuries. Lycium barbarum polysaccharides (LBPs) being recognized as one of the most crucial bioactive compounds found within this plant, with it exhibit a diverse range of pharmacological activities and nutritional functions, thereby generating substantial market demand and broad application prospects. To gain a more comprehensive understanding of LBPs, the review discussed the extraction, purification and structural-property relationships of these compounds. In addition, this review provides a comprehensive summary of the potential mechanisms underlying various biological activities attributed to LBPs, including immune modulation, antioxidant effects, neuroprotection, hepatoprotection, and antitumor properties. The application status and the future research directions of LBPs were subsequently presented. This review will establish a robust foundation and serve as an invaluable resource for future research and advancements in the field of LBPs.</div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"544 ","pages":"Article 109230"},"PeriodicalIF":2.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0