Minerva medica最新文献

{"title":"A case of laparoscopic right hemicolectomy for colon cancer.","authors":"Shengli Huang, Wenzhang Qi, Hongda Li, Shuai Chen, Ye Liu, Pan Liu, Lichao Zhu, Shuanghu Zhang, Huifeng Yang, Yuekun Kang, Wei Zhao, Changyou Wang","doi":"10.23736/S0026-4806.24.09417-5","DOIUrl":"10.23736/S0026-4806.24.09417-5","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"57-60"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of 10% thymoquinone-standardized Nigella sativa oily extract on 24-hour blood pressure profile and nocturnal dipping: a subgroup analysis of a pilot study in postmenopausal hypertensive women.","authors":"Barbara Pala, Francesco DI Pierro, Nicola Zerbinati, Giulia Nardoianni, Paola Gualtieri, Giulia Frank, Marco A Perrone, Laura DI Renzo, Giuliano Tocci","doi":"10.23736/S0026-4806.25.09844-1","DOIUrl":"10.23736/S0026-4806.25.09844-1","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"53-55"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The internal medicine management of diabetic foot syndrome.","authors":"Cesare Miranda, Roberto DA Ros","doi":"10.23736/S0026-4806.25.09805-2","DOIUrl":"10.23736/S0026-4806.25.09805-2","url":null,"abstract":"<p><p>Diabetic foot syndrome (DFS) is a severe complication of diabetes mellitus, representing a significant burden on healthcare systems and patient quality of life. This syndrome encompasses a spectrum of pathologies, including neuropathy, peripheral arterial disease (PAD), infection and foot deformities, culminating in ulceration and potential amputation. Notably, individuals with DFS often present with multiple comorbidities, which significantly influence management and outcomes. This article provides a comprehensive overview of the internal medicine management of DFS, focusing on risk factor identification, preventive strategies, diagnostic approaches, therapeutic interventions and thecritical consideration of comorbidities. The four pillars of management of diabetic foot syndrome are: 1) metabolic management; 2) DFU management; 3) comorbidities management 4) Prevention. A multidisciplinary approach, involving diabetologists, internists, vascular surgeons, infectious disease specialists, podiatrists, and specialized nursing staff, is crucial for optimal patient outcomes.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"36-52"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pollution and health: the role of healthy lifestyle.","authors":"Gianni Testino, Patrizia Balbinot","doi":"10.23736/S0026-4806.25.09839-8","DOIUrl":"10.23736/S0026-4806.25.09839-8","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145566698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of MemoPart for patent foramen ovale closure in real-world patients.","authors":"Alberto M Lanzone, Emiliano Boldi, Paolo Della Pina, Antonio Silvestro, Saverio Continisio, Giuseppe Biondi-Zoccai","doi":"10.23736/S0026-4806.25.09764-2","DOIUrl":"10.23736/S0026-4806.25.09764-2","url":null,"abstract":"<p><strong>Background: </strong>Patent foramen ovale (PFO) is a common congenital heart defect associated with cryptogenic stroke, transient ischemic attacks (TIAs), and migraines. The Multifenestrated MemoPart device is specifically designed to address complex anatomical variations of PFO. This study evaluates the feasibility, safety, and effectiveness of MemoPart for PFO closure in a real-world setting.</p><p><strong>Methods: </strong>Consecutive patients undergoing PFO closure with the MemoPart device were included. Diagnosis was based on transthoracic echocardiography with bubble contrast and quantification of Valsalva maneuver intensity with a Valsalva assist device. Procedural success, adverse events, residual shunts, and clinical outcomes were assessed at baseline and up to 3 months.</p><p><strong>Results: </strong>A total of 60 patients were included in the overall analysis, with age 51.6±12.6 years, and 30 (50%) women. Most participants (46 [77%]) reported a history of stroke, and a Reduce PFO morphology was the most common (34 [57%]). Acutely complete closure was achieved in 59 (98% [91%-100%]) cases, whereas 3-month echocardiographic follow-up showed complete closure in all 60 (100% [94%-100%]). No major or other serious adverse events were reported, and bubble testing showed 0 MES in 49 (82% [70%-91%]) cases. Exploratory ordinal logistic regression suggested that MES were higher in those with complicated (natural logarithm of the odds ratio [LnOR]=1.54 [0.04-3.04], P=0.044) and Tunnel morphologies (LnOR=1.23 [0.01-2.45], P=0.048), as well as with atrial septal aneurysm (LnOR=2.22 [0.54-3.91], P=0.010).</p><p><strong>Conclusions: </strong>MemoPart is a safe and effective option for PFO closure, in routine as well as anatomically complex cases. These findings support its routine use and encourage further long-term studies to confirm its clinical benefits.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"4-10"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia: effects of Robuvit® supplementation on loss of muscular mass and strength.","authors":"Gianni Belcaro, Maria R Cesarone, Mark Dugall, Pietro M Bavera, Andrea Ledda, Claudia Scipione, Valeria Scipione, Marcello Corsi, David Cox, Morio Hosoi, Shu Hu, Roberto Cotellese, Beatrice Feragalli","doi":"10.23736/S0026-4806.25.09735-6","DOIUrl":"10.23736/S0026-4806.25.09735-6","url":null,"abstract":"<p><strong>Background: </strong>The aim of this pilot registry study was to evaluate the effects of the supplement Robuvit^® (French oak wood extract) in otherwise healthy subjects with sarcopenia. Robuvit^® is used in several conditions including convalescence, fatigue, vigor loss, hepatic failure and liver inflammatory conditions. Subjects (30 male subjects and an equivalent control group) were evaluated for a period of 3 months. Standard management (SM) was compared to SM+Robuvit^® (3 cp/day; 300 mg/day).</p><p><strong>Methods: </strong>Sixty male subjects (age 70-80 years) with loss of muscular mass and strength were included; 30 subjects used Robuvit^® 300 mg/day and 30 served as controls. Both groups were comparable at baseline.</p><p><strong>Results: </strong>The tolerability was very good. After 3 months, body fat percentage decreased significantly in the supplement group compared to controls (P<0.05). Hand strength, measured using hand grip dynamometry, was significantly increased in the supplemented subjects compared to controls (P<0.05). Muscular vascularization, assessed using laser Doppler flowmetry, improved significantly in the supplemented group compared to controls (P<0.05). The subjective perception of vigor significantly increased in the subjects using Robuvit^® compared to controls (P<0.05). After 3 months, plasma oxidative stress was significantly decreased with the supplement compared to controls (P<0.05). The urinary excretion of 3-methylhistidine (3MEH) significantly decreased (P<0.05) in the Robuvit^® group compared to controls, suggesting a reduced level of muscle breakdown.</p><p><strong>Conclusions: </strong>In conclusion, this pilot registry study suggests that 'primary' (idiopathic) sarcopenia can be reduced in otherwise healthy subjects with supplementation of Robuvit^®. Robuvit^® increased hand strength, muscular vascularization, subjective vigor and reduced plasma oxidative stress and urinary excretion of 3-methylhistidine a marker of muscle loss after 3 months.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":"117 1","pages":"19-25"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147380227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality, psychological profile and motor-cognitive performance in patients with fibromyalgia: a pilot study.","authors":"Cristina Fonte, Valentina Varalta, Vittorio Schweiger, Elisa Evangelista, Angelica Filosa, Alvise Martini, Mirko Filippetti, Enrico Polati, Nicola Smania, Alessandro Picelli","doi":"10.23736/S0026-4806.25.09781-2","DOIUrl":"10.23736/S0026-4806.25.09781-2","url":null,"abstract":"<p><strong>Background: </strong>Fibromyalgia is characterized by widespread musculoskeletal pain, fatigue, disturbances in cognitive and emotional functioning. Cognitive impairment (so-called \"fibrofog\") is increasingly recognized as a central feature of fibromyalgia. However, its relationship with psychological traits and personality dimensions remains insufficiently explored. This study aimed to examine the interaction between cognitive performance, emotional states, and personality traits in individuals diagnosed with fibromyalgia.</p><p><strong>Methods: </strong>This descriptive pilot study involved 10 female outpatients diagnosed with fibromyalgia according to the criteria of the American College of Rheumatology. Participants underwent a comprehensive assessment including neuropsychological, psychological, personality, and motor evaluations. Instruments used included the Young Schema Questionnaire, the State-Trait Anxiety Inventory, the Beck Depression Inventory, the Brief COPE questionnaire, and a battery of cognitive and motor tests. Statistical analyses were conducted using Spearman's rank correlation coefficient.</p><p><strong>Results: </strong>The most frequently observed maladaptive personality schemas were self-sacrifice (80%) and unrelenting standards (70%). Trait anxiety was present in 80% of participants, and depressive symptoms were reported by 90%. While short-term and long-term memory were generally preserved, 80% of participants showed deficits in divided attention, and 40% demonstrated impaired mobility under dual-task conditions. Significant correlations were found between anxiety and cognitive flexibility, as well as between coping strategies and working memory performance.</p><p><strong>Conclusions: </strong>Patients with fibromyalgia exhibit a complex cognitive-emotional profile characterized by attentional deficits, maladaptive personality traits, and elevated psychological distress. These findings emphasize the importance of multidimensional assessment and suggest that interventions targeting personality schemas and coping mechanisms may improve cognitive and functional outcomes in this population.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"11-18"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145672975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An umbrella review encompassing 42 systematic reviews on medical applications of ChatGPT.","authors":"Sara Ramadan, Camilla Calvieri, Abraham E Gracia-Ramos, Gabriela Roselli Ferrari, Martino Pepe, Giuseppe Biondi-Zoccai","doi":"10.23736/S0026-4806.25.09664-8","DOIUrl":"10.23736/S0026-4806.25.09664-8","url":null,"abstract":"<p><p>Since its release, ChatGPT, which is a novel artificial intelligence (AI) tool, has become a global phenomenon with its utilization in various fields of life. In particular, ChatGPT has many potential uses in the medical field, and its evidence base is expanding momentously. We thus aimed at synthesizing the evidence on medical applications of ChatGPT. After searching several databases, 4351 articles were initially retrieved, eventually yielding that we retrieved 42 systematic reviews or meta-analyses. The main fields of applications were medical education, medical research, and actual use in clinical practice. Additional areas addressed in the literature focused on ethics issues, using ChatGPT as assistance in medical writing and research, as well as ChatGPT's demonstrated medical knowledge. While these reviews demonstrated the potential transformative role of ChatGPT in the medical field, there were also common areas of concern expressed in the articles. A frequently noted concern was inaccuracy, as well as the risk of hallucination. Other key limitations were limited validity, reliability, and privacy issues. In conclusion, the totality of evidence suggests that ChatGPT can be a valuable tool in the medical field, with favorable applications ranging from generation to dissemination and application of clinical knowledge. However, further refinements are required to ensure that its output can be directly applied to medical activities while protecting patient safety and rights.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":"117 1","pages":"26-35"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147380175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous recombinant human prourokinase for acute ischemic stroke: a network meta-analysis.","authors":"João V Fernandes, João V Ramos, Maurus M Holanda","doi":"10.23736/S0026-4806.25.09737-X","DOIUrl":"10.23736/S0026-4806.25.09737-X","url":null,"abstract":"<p><strong>Introduction: </strong>Acute ischemic stroke (AIS) requires prompt thrombolytic therapy to restore cerebral perfusion. Recombinant human prourokinase (rhPro-UK) has emerged as a potential alternative to standard agents, but the optimal dosage remains unclear.</p><p><strong>Evidence acquisition: </strong>A systematic review and network meta-analysis was conducted using PubMed and Embase up to January 27, 2025. Eligible studies were randomized controlled trials (RCTs) comparing intravenous rhPro-UK dosages in adults with AIS. Outcomes included changes in NIHSS scores (24 hours and 7 days), mRS scores (0-1 and 0-2), all-cause mortality, serious adverse events (SAEs), and symptomatic intracranial hemorrhage (SIH). Data were analyzed using a Bayesian random-effects model in R (v4.4.2), with results reported as mean differences (MDs), odds ratios (ORs), and risk differences (RDs) with 95% confidence intervals (CIs).</p><p><strong>Evidence synthesis: </strong>Eight RCTs (N.=4309; mean age 64.7 years; 33.1% female) were included. Both 35 mg and 50 mg rhPro-UK improved NIHSS scores at 24 hours (MD: -1.03 and -0.44) and 7 days (MD: -1.19 and -0.86) versus standard care. The combination of 40 mg rhPro-UK + alteplase (ALT) showed the highest probability of achieving mRS 0-2 (OR: 1.59). The 50 mg dose was associated with increased mortality (OR: 2.34), while the 35 mg dose had the highest estimated SIH risk (OR: 4.73).</p><p><strong>Conclusions: </strong>Both 35 mg and 50 mg rhPro-UK improve early neurological outcomes. However, 40 mg rhPro-UK + ALT may offer the most favorable efficacy-safety profile. Further trials are warranted to optimize dosing strategies.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"461-467"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focus on digital construction of smart cities from COVID-19 epidemic prevention and control.","authors":"Xing Wang, Huaiying Shi, Yichen Zhang, Lijun Wu, Xun Gong, Hongwei Xiong, Xuanxuan Wang","doi":"10.23736/S0026-4806.23.08845-6","DOIUrl":"10.23736/S0026-4806.23.08845-6","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"507-509"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}