Minerva medica最新文献

The multidisciplinary team reduces the time to idiopathic pulmonary fibrosis diagnosis in a real-life setting.

Minerva medica Pub Date : 2025-02-17 DOI: 10.23736/S0026-4806.25.09643-0

Tiziana LA Blasca, Alida Benfante, Riccardo Messina, Emanuele Grassedonio, Salvatore Battaglia, Giada Capizzi, Irene DI Leo, Laura Napoli, Sergio Palma, Pietro Provinzano, Alessandra Tomasello, Nicola Scichilone

{"title":"The multidisciplinary team reduces the time to idiopathic pulmonary fibrosis diagnosis in a real-life setting.","authors":"Tiziana LA Blasca, Alida Benfante, Riccardo Messina, Emanuele Grassedonio, Salvatore Battaglia, Giada Capizzi, Irene DI Leo, Laura Napoli, Sergio Palma, Pietro Provinzano, Alessandra Tomasello, Nicola Scichilone","doi":"10.23736/S0026-4806.25.09643-0","DOIUrl":"https://doi.org/10.23736/S0026-4806.25.09643-0","url":null,"abstract":"Background: Early diagnosis of idiopathic pulmonary fibrosis (IPF) is fundamental to slow disease progression; multidisciplinary teams (MDTs) play a central role in posing the final diagnosis of IPF, thus aiming to improve patient outcomes. However, the practical implementation of MDTs in clinical real-life settings may be hindered by the lack of local expertise or time constraints, with the diagnosis being made without the support of complementary professional health care figures. This study aims to evaluate the impact of MDT meetings on the latency between the symptom onset and the final diagnosis of IPF.Methods: Patients referred to a regional center for IPF between January 2019 and August 2019 were included. The length of time to pose a definite diagnosis by means of MDT evaluation was compared with that of patients diagnosed elsewhere (no MDT evaluation) in an observational case-control investigation.Results: Among 24 IPF patients, those evaluated by MDT (M/F: 14/2, age: 69.8±8.2 yrs) showed a time interval from the first outpatient visit to the definite diagnosis of 3±2.3 months; on the other hand, patients in the control group (M/F: 7/1, age: 76.9±7.7 yrs) showed a time interval of 12.8±9.4 months (P=0.02). The time elapsed between the onset of symptoms and the definite diagnosis was 11.1±5.3 months for patients evaluated within the MDT, compared to 33.8±21.5 months for the control group (P=0.02).Conclusions: These exploratory findings confirm the essential role of the MDT in the early diagnosis of IPF, thus discouraging the acquisition of diagnosis solely on individual basis. The current findings highlight the need for the implementation of MDTs in clinical practice to optimize patient care.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing age and mortality due to pollution exposure: a comprehensive review.

Minerva medica Pub Date : 2025-02-17 DOI: 10.23736/S0026-4806.24.09611-3

Yashendra Sethi, Arsalan Moinuddin, Giuseppe Biondi-Zoccai

{"title":"Advancing age and mortality due to pollution exposure: a comprehensive review.","authors":"Yashendra Sethi, Arsalan Moinuddin, Giuseppe Biondi-Zoccai","doi":"10.23736/S0026-4806.24.09611-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09611-3","url":null,"abstract":"The global aging population has been increasingly vulnerable to environmental stressors, particularly air pollution. Advancing age is associated with physiological declines and a higher prevalence of chronic diseases, heightening susceptibility to pollution-related health effects. This review explores the relationship between advancing age and mortality/morbidity due to pollution exposure, consolidating evidence on how pollution exacerbates health risks in elderly populations. Based on the epidemiological evidence, this comprehensive literature review evaluates the interaction between aging, pollution exposure, and the biological mechanisms that make older adults more vulnerable to pollution-related mortality/morbidity. Google Scholar, PubMed, and Scopus were systematically searched to identify relevant studies, including cohort studies, meta-analyses, and reviews. Studies were selected based on their focus on air pollution, aging populations, and mortality. Inclusion criteria included peer-reviewed articles addressing pollution-related health outcomes in older adults, specifically emphasizing cardiovascular, respiratory, and neurological impacts. Aging amplifies the harmful effects of air pollution through mechanisms like oxidative stress, impaired immune responses, and chronic inflammation. Elderly populations are disproportionately affected by pollutants such as particulate matter (PM2.5), nitrogen dioxide (NO<inf>2</inf>), and ozone. Mortality, specifically due to cardiovascular, respiratory, and neurodegenerative diseases, is significantly higher in older adults exposed to long-term pollution. Air pollution, as an effect modifier, intensifies the health risks associated with aging. Older adults face heightened mortality risks due to pollution, demanding public health strategies to prioritize pollution reduction and protective interventions at individual and population levels.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psoriasis and diabetes: a review of the pathophysiological and therapeutic interconnections.

Minerva medica Pub Date : 2025-02-17 DOI: 10.23736/S0026-4806.24.09570-3

David A DE Luca, Cristian Papara, Tomasz Hawro, Diamant Thaçi

{"title":"Psoriasis and diabetes: a review of the pathophysiological and therapeutic interconnections.","authors":"David A DE Luca, Cristian Papara, Tomasz Hawro, Diamant Thaçi","doi":"10.23736/S0026-4806.24.09570-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09570-3","url":null,"abstract":"Introduction: Psoriasis is a chronic, immune-mediated skin disorder associated with systemic conditions like cardiovascular diseases, metabolic syndrome, and type 2 diabetes mellitus. Individuals with psoriasis show a higher risk of diabetes compared to the general population. This review aims to examine the relationship between the physiopathology and treatment of psoriasis and diabetes mellitus.Evidence acquisition: A systematic search was conducted across PubMed and Google Scholar up to July 2024. Observational studies and clinical trials involving all age groups and genders were included, focusing on the pathophysiology, inflammatory pathways, and therapeutic interventions for psoriasis and diabetes.Evidence synthesis: Evidence consistently showed an increased prevalence of type 2 diabetes among psoriasis patients. The IL-23/IL-17 axis plays a critical role in the inflammation driving both psoriasis and insulin resistance. This inflammation promotes metabolic syndrome components such as obesity. Conversely, insulin resistance and obesity amplify systemic inflammation, creating a vicious cycle in psoriasis patients. Integrated treatment approaches, combining targeted pharmacologic therapies with lifestyle modifications, demonstrated potential in managing both conditions effectively. Multidisciplinary care is vital to address the dermatological and metabolic aspects of these interconnected diseases.Conclusions: The shared inflammatory pathways between psoriasis and type 2 diabetes highlight the complex, bidirectional relationship between the two. Integrated therapeutic strategies that include lifestyle changes and targeted drug interventions show promise in improving outcomes for individuals affected by both conditions.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insomnia disorder.

Minerva medica Pub Date : 2025-02-11 DOI: 10.23736/S0026-4806.25.09690-9

Luigi Ferini-Strambi

{"title":"Insomnia disorder.","authors":"Luigi Ferini-Strambi","doi":"10.23736/S0026-4806.25.09690-9","DOIUrl":"https://doi.org/10.23736/S0026-4806.25.09690-9","url":null,"abstract":"Insomnia is a prevalent public health issue, characterized by dissatisfaction with the duration, continuity, and quality of sleep. It is closely associated with daytime symptoms, which are essential for diagnosing insomnia disorder. The condition is more common among women, middle-aged and older adults, and individuals with coexisting mental or physical health conditions. Evidence suggests that insomnia increases the risk of various health problems. Addressing insomnia is therefore crucial not only to enhance patients' quality of life but also to mitigate its significant health, social, and economic impacts. However, further studies are needed to evaluate the cost-effectiveness of insomnia treatments. Cognitive behavioral therapy for insomnia (CBT-I) is recommended as the first-line treatment for chronic insomnia in adults. When CBT-I proves ineffective or is unavailable, pharmacological treatments may be considered. Benzodiazepines (BZs) and benzodiazepine receptor agonists (BZRAs) are suitable for short-term treatment (up to 4 weeks). Among BZs, triazolam is notable for its short half-life and demonstrated efficacy in treating sleep-onset and middle-of-the-night (MOTN) insomnia, supported by robust clinical evidence. Additionally, triazolam does not impair psychomotor performance. In certain cases, longer-term use of BZs or BZRAs may be appropriate; however, this approach requires careful individual assessment of the benefits and risks. Non-nightly use of hypnotic medications may also be a viable option for patients who do not require nightly treatment. Low-dose sedating antidepressants may be considered for short-term insomnia management (off-label), while antipsychotics and antihistamines are not recommended for this purpose. Orexin receptor antagonists are an option for treating insomnia for up to three months. It is important to note that although insomnia guidelines are based on daily use as evaluated in randomized controlled trials, clinical practice may vary.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical approach to the diagnosis and management of small bowel bleeding. 诊断和处理小肠出血的临床方法。

Minerva medica Pub Date : 2025-02-01 Epub Date: 2024-09-26 DOI: 10.23736/S0026-4806.24.09361-3

Sanket Bhattarai, Sandra Algarin Perneth, Huber Padilla Zambrano, Cadman L Leggett

引用次数: 0

Venous thromboembolism during pregnancy and postpartum period: an updated review. 孕期和产后静脉血栓栓塞：最新综述。

Minerva medica Pub Date : 2025-02-01 Epub Date: 2024-10-11 DOI: 10.23736/S0026-4806.24.09242-5

Sanaullah Mojaddedi, Javairia Jamil, Andrew Abraham, Dawood Jamil, Hend Mansoor, Islam Y Elgendy

引用次数: 0

Flying to high-altitude destinations. 飞往高海拔目的地

Minerva medica Pub Date : 2025-02-01 Epub Date: 2024-08-05 DOI: 10.23736/S0026-4806.24.09286-3

Johannes Burtscher, Hannes Gatterer, David Niederseer, Karin Vonbank, Martin Burtscher

{"title":"Flying to high-altitude destinations.","authors":"Johannes Burtscher, Hannes Gatterer, David Niederseer, Karin Vonbank, Martin Burtscher","doi":"10.23736/S0026-4806.24.09286-3","DOIUrl":"10.23736/S0026-4806.24.09286-3","url":null,"abstract":"Every year millions of people fly to high-altitude destinations. They thereby expose themselves to specific high-altitude conditions. The hypoxic environment (low ambient oxygen availability) constitutes a major factor affecting health and well-being at high altitude. While the oxygen availability is already moderately reduced inside the aircraft cabin, this reduction becomes aggravated when leaving the plane at high-altitude destinations. Especially if not pre-acclimatized, the risk of suffering from high-altitude illnesses, e.g., acute mountain sickness, high-altitude cerebral or pulmonary edema, increases with the level of altitude. In addition, diminished oxygen availability impairs exercise tolerance, which not only limits physical activity at high altitude but may also provoke symptomatic exacerbation of pre-existing diseases. Moreover, the cold and dry ambient air and increased levels of solar radiation may contribute to adverse health effects at higher altitude. Thus, medical pre-examination and pre-flight advice, and proper preparation (pre-acclimatization, exercise training, and potentially adaptation of pharmacological regimes) are of utmost importance to reduce negative health impacts and frustrating travel experiences.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"43-61"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The "Burden of Skin Diseases" Project: a population-based study on 44,689 participants from 27 European countries. 皮肤病负担 "项目：一项针对 27 个欧洲国家 44 689 名参与者的人口研究。

Minerva medica Pub Date : 2025-02-01 Epub Date: 2024-05-14 DOI: 10.23736/S0026-4806.24.09262-0

Carle Paul, Alexander J Stratigos, Tamar Nijsten, Paolo Gisondi, Carmen Salavastru, Martin Röecken, Charles Taieb, Francesca Sampogna, Myrto Trakatelli, Luis Puig, Marie A Richard

引用次数: 0

Reliability and validity of the Italian version of the Caregiver Priorities and Child Health Index of Life with Disabilities in children with cerebral palsy. 意大利语版脑瘫儿童照顾者优先事项和残疾儿童生活健康指数的可靠性和有效性。

Minerva medica Pub Date : 2025-02-01 Epub Date: 2024-11-27 DOI: 10.23736/S0026-4806.24.09537-5

Federica Giorgi, Nicolò Sproccati, Corrado Zenesini, Francesca R Pulvirenti, Nicoletta Battisti, Nadia Sommella, Alessandra Feliciangeli, Antonella Cersosimo

{"title":"Reliability and validity of the Italian version of the Caregiver Priorities and Child Health Index of Life with Disabilities in children with cerebral palsy.","authors":"Federica Giorgi, Nicolò Sproccati, Corrado Zenesini, Francesca R Pulvirenti, Nicoletta Battisti, Nadia Sommella, Alessandra Feliciangeli, Antonella Cersosimo","doi":"10.23736/S0026-4806.24.09537-5","DOIUrl":"10.23736/S0026-4806.24.09537-5","url":null,"abstract":"Background: The Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD™) questionnaire is a reliable indirect indicator of functional, health status and quality of life in children with severe Cerebral Palsy (CP), as well as the caregiving burden. The aim of the study is to validate the Italian translation of Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD™) questionnaire and assess its reliability and validity.Methods: A cross-sectional study was conducted. The study involved 60 caregivers of children with CP, classified according to the Gross Motor Function Classification System (GMFCS) levels I-V. There was a self-compilation of the CPCHILD™ by primary caregivers during the clinical visit and a re-administration of the questionnaire 2-3 weeks after the first to a defined sample (N.=30, GMFCS IV-V). The Italian version of CPCHILD™'s psychometric properties were evaluated through internal consistency, test-retest reliability, and validity analyses.Results: The translated CPCHILD™ questionnaire showed excellent test-retest reliability (Intraclass Correlation Coefficient - ICC=0.97) across most sections, with significant construct validity, differentiating well between the various GMFCS levels. The internal consistency was robust (Cronbach's alpha=0.852) except for the health section. The face validity indicated high relevance of the questionnaire items to the caregivers, particularly in emotional well-being and social interaction.Conclusions: The Italian version of CPCHILD™ questionnaire is a reliable and valid tool for assessing the quality of life in children with severe CP, offering insights into the care burden and health status impacts perceived by caregivers.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"22-30"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the language of chronic pain stories through a Facebook page. A qualitative study on narratives and unmet needs.

Minerva medica Pub Date : 2025-02-01 DOI: 10.23736/S0026-4806.24.09577-6

Maria Giulia Marini, Alessandro Braga, Chiara Lattuada, Antonietta Cappuccio, Fabio Bianco Madau

{"title":"Exploring the language of chronic pain stories through a Facebook page. A qualitative study on narratives and unmet needs.","authors":"Maria Giulia Marini, Alessandro Braga, Chiara Lattuada, Antonietta Cappuccio, Fabio Bianco Madau","doi":"10.23736/S0026-4806.24.09577-6","DOIUrl":"10.23736/S0026-4806.24.09577-6","url":null,"abstract":"Background: Dimensione Sollievo (Dimension of Relief) and its Facebook page represent a patient-centered social media initiative focused on chronic pain. This platform provides users with accurate resources on chronic pain and offers a virtual space for peer interaction - a crucial aspect for a condition often lacking proper recognition. The study's primary objective was to analyze the content in relation to unmet needs, with a secondary objective to explore the role of narrative medicine (NM) in this form of social communication.Methods: Posts, replies, and comments from the Facebook page between 2020 and 2023 were analyzed using thematic frameworks such as Frank, Kleinmann, Launer classifications, and Berne's transactional analysis. Language styles, semantics, word frequency, and metaphors were also examined. Narratives were analyzed through Nvivo software and Microsoft Office tools.Results: Users embraced the Facebook page as a safe space for interaction, where they found understanding and connection, unlike their experiences outside the community. While interactions were generally brief, they intensified around issues where users perceived injustices, such as the lack of recognition of their condition by medical professionals and family, and challenges in accessing benefits. Thematic analysis revealed that the most prominent theme was the dimension of disease, with many narratives expressing difficulty coping and a lack of progress.Conclusions: The application of narrative medicine (NM) tools highlights both explicit and unconscious patient needs, such as the desire to be heard and acknowledged. This study is the first to explore NM's potential in chronic pain. Implementing NM tools through informed moderation could transform pain management culture, improving treatment approaches and enhancing the overall community experience.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":"116 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0