Minerva medica最新文献

Hemoptysis of unknown origin: let's put in order the puzzle pieces. 来历不明的咯血：让我们来整理一下。

Minerva medica Pub Date : 2024-12-20 DOI: 10.23736/S0026-4806.24.09597-1

Francesco Gavelli, Mattia Bellan, Filippo Patrucco

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Type 2 diabetes, heart failure and the treatment of their comorbidity. 2型糖尿病、心力衰竭及其合并症的治疗。

Minerva medica Pub Date : 2024-12-06 DOI: 10.23736/S0026-4806.24.09264-4

Si Wang, Sheyu Li

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Diagnosis and treatment of periorbital and orbital cellulitis in children. 儿童眼眶周围及眼眶蜂窝织炎的诊断与治疗。

Minerva medica Pub Date : 2024-12-06 DOI: 10.23736/S0026-4806.24.09357-1

Xing Zhang, Chen Wang, Haixia Liu, Lulin Bi, Shuxin Wen

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Application of percutaneous intervertebral foraminoscopic discectomy in lumbar disc herniation. 经皮椎间孔镜椎间盘切除术在腰椎间盘突出症中的应用。

Minerva medica Pub Date : 2024-12-06 DOI: 10.23736/S0026-4806.24.09403-5

Zhi Ruan, Qinzheng Fang, Xiao Zhang, Liang Shang, Hui Ma

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Pulmonary hypertension in patients affected by sleep-related breathing disorders: up to date from the literature. 睡眠呼吸障碍患者的肺动脉高压：最新文献。

Minerva medica Pub Date : 2024-12-01 Epub Date: 2024-07-17 DOI: 10.23736/S0026-4806.24.09112-2

Elvia Battaglia, Elena Compalati, Luca Mapelli, Agata Lax, Paola Pierucci, Paolo Solidoro, Paolo Banfi

{"title":"Pulmonary hypertension in patients affected by sleep-related breathing disorders: up to date from the literature.","authors":"Elvia Battaglia, Elena Compalati, Luca Mapelli, Agata Lax, Paola Pierucci, Paolo Solidoro, Paolo Banfi","doi":"10.23736/S0026-4806.24.09112-2","DOIUrl":"10.23736/S0026-4806.24.09112-2","url":null,"abstract":"Sleep-related breathing disorders (SBD) are conditions of abnormal and difficult respiration during sleep, including chronic snoring, obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation disorders and sleep-related hypoxemia. Some of them have a limited impact on health, but others (e.g., OSA) can have serious consequences, because of their dangerous effects on sleep and the hematic balance of oxygen and carbon dioxide. According to several population-based studies, prevalence of OSA is relatively high, approximately 3-7% for adult males and 2-5% for adult females in the general population. However, methodological differences and difficulties in characterizing this syndrome yielded to variability in estimates. Moreover, it is estimated that only about 40% of patients with OSA are diagnosed, which can lead to underestimation of disease prevalence. OSA is directly correlated with age and male sex and to risk factors such as obesity. Several studies found that OSA is associated with an increased risk of diabetes, some cancer types, cardiovascular and cerebrovascular diseases, such as hypertension, coronary artery disease and stroke. Pulmonary hypertension (PH), a noted cardiovascular disease, is significantly associated with sleep-related breathing disorders and lot of scientific studies published in the literature demonstrated a strong link between these conditions and the development of pulmonary hypertension PH. PH is relatively less common than sleep-related breathing disorders. The purpose of this systematic review is to analyze both the current knowledge around the consequences that SBD may have on pulmonary hemodynamics and the effects resulting from pharmacological and non-pharmacological treatments of SDB on PH.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"671-688"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenosine triphosphate: a new player in complex regional pain syndrome type 1. 三磷酸腺苷：1 型复杂性区域疼痛综合征的新角色。

Minerva medica Pub Date : 2024-12-01 Epub Date: 2024-08-05 DOI: 10.23736/S0026-4806.24.09345-5

Sergio Rosini, Stefano Rosini, Gianantonio Saviola, Luigi Molfetta

{"title":"Adenosine triphosphate: a new player in complex regional pain syndrome type 1.","authors":"Sergio Rosini, Stefano Rosini, Gianantonio Saviola, Luigi Molfetta","doi":"10.23736/S0026-4806.24.09345-5","DOIUrl":"10.23736/S0026-4806.24.09345-5","url":null,"abstract":"The complex regional pain syndrome type 1 (CRPS-1) is one of the most discussed painful syndromes due to the variability and severity of its symptoms. CRPS-1 generally occurs after a trauma, a fracture or a sprain followed by an immobilization. Classical diagnostic criteria are not always clear; hence, the diagnosis is difficult. The definition of CRPS itself defines and considers the pain as key symptom neglecting the bone damage. Early CRPS involves the activation of the innate cutaneous immune system with altered sensory and sympathetic signaling, activation and proliferation of keratinocytes and mast cells in addition to the release of inflammatory mediators and pain. The role of the immune system and the response to the disease is becoming clearer as the microglia is activated as a result of injury and can induce a central sensitization while astrocytes can maintain the process. Adenosine triphosphate (ATP) exerts a fundamental role in the activation of innate cutaneous immune system, in the proliferation of keratinocytes and mast cells, in the release of several proinflammatory cytokines and in the microglia activation. It is essential to intervene on this pathology as soon as possible with drugs, as clodronate, able to reduce bone marrow edema and pain through the inhibition of the primary inflammatory process and the immune reaction, limiting the activation of macrophages and the release of cytokines activating nuclear growth factor (NGF). In this review the role of ATP, bisphosphonates and rehabilitation are discussed.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"651-659"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fragmented QRS in dialysis patients: too simple to be truly useful or a potential prognostic and diagnostic tool? 透析患者的 QRS 波形片断：是过于简单而无法真正发挥作用，还是一种潜在的预后和诊断工具？

Minerva medica Pub Date : 2024-12-01 Epub Date: 2024-05-09 DOI: 10.23736/S0026-4806.24.09351-0

Martina Cacciapuoti, Lucia F Stefanelli, Elisabetta Bettin, Elena Sgrò, Laura DE Michieli, Ugo Vertolli, Federico Nalesso, Lorenzo A Calò

引用次数: 0

Translation, cross-cultural adaptation, and validation of the Italian version of the Parkinson's disease caregiver burden questionnaire (PDCB-I). 意大利语版帕金森病护理者负担问卷 (PDCB-I) 的翻译、跨文化改编和验证。

Minerva medica Pub Date : 2024-12-01 Epub Date: 2024-09-18 DOI: 10.23736/S0026-4806.24.09494-1

Sara Gherardini, Elena Porri, Matilde Dugini, Valentina Santoro, Matteo Paci

{"title":"Translation, cross-cultural adaptation, and validation of the Italian version of the Parkinson's disease caregiver burden questionnaire (PDCB-I).","authors":"Sara Gherardini, Elena Porri, Matilde Dugini, Valentina Santoro, Matteo Paci","doi":"10.23736/S0026-4806.24.09494-1","DOIUrl":"10.23736/S0026-4806.24.09494-1","url":null,"abstract":"Background: To translate and cross-culturally adapt the Parkinson's Disease Caregiver Burden questionnaire (PDBC) into Italian language and to evaluate the psychometric properties of the Italian version in terms of test-retest reliability, internal consistency, and construct validity.Methods: The PDBC-I was developed by forward-backward translation to establish correspondence with the original English latest version. Psychometric properties were estimated in a sample of primary caregivers of individuals with Parkinson's disease. Reliability testing included internal consistency (Cronbach's alpha), test-retest reliability (ICC), the standard error of measurement (SEM) and the minimal detectable change (MDC), also expressed as percentage (MDC%). Validity was estimated by comparing the PDBC -I to the Caregiver Burden Inventory (CBI) and the Short Form 36 (SF-36) (Pearson correlation coefficient).Results: The questionnaire was administered to 65 caregivers, showing internal consistency of 0.934. ICC value was 0.811 (95% CI 0.708-0.880) for test-retest reliability, and the SEM and the MDC (MDC%) were 5.04 and 13.97 (38.21%), respectively. Low to moderate correlation with all other investigated scales (CBI: r=0.693; SF-36 physical score: r=-0.309; SF-36 mental score: r=-0.588; SF36 total score: -0.470) were found.Conclusions: Despite the PDCB-I holds acceptable psychometric properties to be used in clinical settings of Italian-speaking Countries as a measure of caregiver burden in caregivers of individuals with Parkinson Disease, the caregiver might require the support of a clinician to finalize the compilation of the questionnaire.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"635-642"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noninvasive tools for the assessment of fibrosis in metabolic dysfunction-associated steatotic liver disease. 评估代谢功能障碍相关脂肪性肝病纤维化的无创工具。

Minerva medica Pub Date : 2024-12-01 Epub Date: 2024-09-16 DOI: 10.23736/S0026-4806.24.09290-5

Joana Rigor, Maria E Martins, Beatriz Passos, Raquel Oliveira, Daniela Martins-Mendes

{"title":"Noninvasive tools for the assessment of fibrosis in metabolic dysfunction-associated steatotic liver disease.","authors":"Joana Rigor, Maria E Martins, Beatriz Passos, Raquel Oliveira, Daniela Martins-Mendes","doi":"10.23736/S0026-4806.24.09290-5","DOIUrl":"10.23736/S0026-4806.24.09290-5","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD), previously nonalcoholic fatty liver disease (NAFLD), is the number one chronic liver disorder worldwide. Progression to advanced fibrosis marks the emergence of a significant risk of liver-related negative outcomes. However, only a minority of patients will present at this stage. Since widespread liver biopsy in unfeasible at such high disease prevalence, there was a need to develop noninvasive tests (NITs) that could easily and reliably be applied to patients with MASLD, regardless of clinical setting. The NITs include simple scores, like the fibrosis-4 (FIB-4) Index, patented serum tests, like the Enhanced Liver Fibrosis test (ELF™), and imaging-based modalities, like the vibration-controlled transient elastography (VCTE). Guidelines suggests a stepwise approach that utilizes more than one NIT, with FIB-4 <1.30 being used as a first step to rule out patients that do not need further testing. Subsequent choice of NIT will be influenced by setting, cost, and local availability. While these NITs are accurate, they are not perfect. As such, research is ongoing. A promising avenue is that of omics, a group of technologies that provide concomitant results on a large number of molecules (and other variables). With the advance of artificial intelligence, new NITs may arise from large demographic, biochemical, and radiological data sets.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"660-670"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BNT162b2 vaccine booster dose did not influence the activity of the exudative form of age-related macular degeneration during anti-vascular endothelial growth factor therapy. 在抗血管内皮生长因子治疗期间，BNT162b2 疫苗加强剂量不会影响老年性黄斑变性渗出型的活性。

Minerva medica Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.23736/S0026-4806.24.09379-0

Bernadetta Płatkowska-Adamska, Agnieszka Bociek, Magdalena Kal, Dorota Zarębska-Michaluk, Dominik Odrobina

{"title":"BNT162b2 vaccine booster dose did not influence the activity of the exudative form of age-related macular degeneration during anti-vascular endothelial growth factor therapy.","authors":"Bernadetta Płatkowska-Adamska, Agnieszka Bociek, Magdalena Kal, Dorota Zarębska-Michaluk, Dominik Odrobina","doi":"10.23736/S0026-4806.24.09379-0","DOIUrl":"10.23736/S0026-4806.24.09379-0","url":null,"abstract":"Background: Due to safety concerns, patients were hesitant to receive a booster dose of COVID-19 vaccine. In this study, we investigated whether neovascular age-related macular degeneration activity deteriorated after receiving the booster dose of the BNT162b2 vaccine.Methods: Optical coherence tomography (OCT) of the macula, best-corrected visual acuity (BCVA), and slit-lamp examination data were collected from 89 patients. All these individuals were diagnosed with neovascular age-related macular degeneration (AMD) and treated with intravitreal injections of aflibercept or ranibizumab. During the process of treatment, patients received a booster dose of the BNT162b2 vaccine. Time points included two visits before (marked as \"-2\", \"-1\") and two visits after (marked as \"1\", \"2\") the uptake of the booster dose.Results: There were significant differences in the average thickness and total volume of the macula during follow-up. Moreover, a decreased average thickness, total volume, total thickness of the macula, subretinal fluid thickness, and subretinal complex thickness was observed between the time points \"-2\" and \"2\", but only in the aflibercept group. There were no significant differences in the frequency of occurring intraretinal cysts, subretinal fluid, serous retinal pigment epithelial detachments retinal hemorrhage, subretinal hyperreflective material, complete RPE and outer retinal atrophy, and BCVA before and after the booster dose.Conclusions: These results demonstrate that the BNT162b2 vaccine booster dose did not deteriorate the course of neovascular AMD.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"643-650"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0