Minerva medica最新文献_第2页

The improvement of clinical effect of Chinese medicine directed transmission on patients with endometritis. 中药导引输液对子宫内膜炎患者临床疗效的改善。

Minerva medica Pub Date : 2024-09-05 DOI: 10.23736/S0026-4806.24.09305-4

Lixue Feng, Lingjuan Song, Xiuqin Zhang

引用次数: 0

Application of auricular point therapy in multi-mode postoperative analgesia after osteotomy and orthopedic surgery of lower limbs. 耳穴疗法在下肢截骨和矫形手术后多模式术后镇痛中的应用。

Minerva medica Pub Date : 2024-09-05 DOI: 10.23736/S0026-4806.24.09366-2

Xiang Wang, Maoxi Chen, Jie Li, Guoying Wang, Daobo Xing

引用次数: 0

Adenosine triphosphate: a new player in complex regional pain syndrome type 1. 三磷酸腺苷：1 型复杂性区域疼痛综合征的新角色。

Minerva medica Pub Date : 2024-08-05 DOI: 10.23736/S0026-4806.24.09345-5

Sergio Rosini, Stefano Rosini, Gianantonio Saviola, Luigi Molfetta

{"title":"Adenosine triphosphate: a new player in complex regional pain syndrome type 1.","authors":"Sergio Rosini, Stefano Rosini, Gianantonio Saviola, Luigi Molfetta","doi":"10.23736/S0026-4806.24.09345-5","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09345-5","url":null,"abstract":"The complex regional pain syndrome type 1 (CRPS-1) is one of the most discussed painful syndromes due to the variability and severity of its symptoms. CRPS-1 generally occurs after a trauma, a fracture or a sprain followed by an immobilization. Classical diagnostic criteria are not always clear; hence, the diagnosis is difficult. The definition of CRPS itself defines and considers the pain as key symptom neglecting the bone damage. Early CRPS involves the activation of the innate cutaneous immune system with altered sensory and sympathetic signaling, activation and proliferation of keratinocytes and mast cells in addition to the release of inflammatory mediators and pain. The role of the immune system and the response to the disease is becoming clearer as the microglia is activated as a result of injury and can induce a central sensitization while astrocytes can maintain the process. Adenosine triphosphate (ATP) exerts a fundamental role in the activation of innate cutaneous immune system, in the proliferation of keratinocytes and mast cells, in the release of several proinflammatory cytokines and in the microglia activation. It is essential to intervene on this pathology as soon as possible with drugs, as clodronate, able to reduce bone marrow edema and pain through the inhibition of the primary inflammatory process and the immune reaction, limiting the activation of macrophages and the release of cytokines activating nuclear growth factor (NGF). In this review the role of ATP, bisphosphonates and rehabilitation are discussed.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flying to high-altitude destinations. 飞往高海拔目的地

Minerva medica Pub Date : 2024-08-05 DOI: 10.23736/S0026-4806.24.09286-3

Johannes Burtscher, Hannes Gatterer, David Niederseer, Karin Vonbank, Martin Burtscher

{"title":"Flying to high-altitude destinations.","authors":"Johannes Burtscher, Hannes Gatterer, David Niederseer, Karin Vonbank, Martin Burtscher","doi":"10.23736/S0026-4806.24.09286-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09286-3","url":null,"abstract":"Every year millions of people fly to high-altitude destinations. They thereby expose themselves to specific high-altitude conditions. The hypoxic environment (low ambient oxygen availability) constitutes a major factor affecting health and well-being at high altitude. While the oxygen availability is already moderately reduced inside the aircraft cabin, this reduction becomes aggravated when leaving the plane at high-altitude destinations. Especially if not pre-acclimatized, the risk of suffering from high-altitude illnesses, e.g., acute mountain sickness, high-altitude cerebral or pulmonary edema, increases with the level of altitude. In addition, diminished oxygen availability impairs exercise tolerance, which not only limits physical activity at high altitude but may also provoke symptomatic exacerbation of pre-existing diseases. Moreover, the cold and dry ambient air and increased levels of solar radiation may contribute to adverse health effects at higher altitude. Thus, medical pre-examination and pre-flight advice, and proper preparation (pre-acclimatization, exercise training, and potentially adaptation of pharmacological regimes) are of utmost importance to reduce negative health impacts and frustrating travel experiences.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison and analysis of maternal and neonatal outcomes between vaginal delivery and cesarean section. 阴道分娩与剖腹产对产妇和新生儿预后的比较与分析。

Minerva medica Pub Date : 2024-08-05 DOI: 10.23736/S0026-4806.24.09316-9

Ying Huang, Lixiang Feng, Jiaolian Wang, Mengdie Chen

引用次数: 0

Exploring the impact of Cyp2C19 genetic polymorphism on the neurological and endothelial functions of acute cerebral infarction patients treated with dibenzyline. 探讨Cyp2C19基因多态性对急性脑梗死患者接受二苄嘧啶治疗后神经功能和血管内皮功能的影响

Minerva medica Pub Date : 2024-07-30 DOI: 10.23736/S0026-4806.24.09294-2

Qingchuan Ma, Ni Mu, Xi Wu, Bing Yang, Na Xu

引用次数: 0

Rare homozygous exon 6 deletion in the STAT5b gene. STAT5b 基因中罕见的第 6 号外显子同源缺失。

Minerva medica Pub Date : 2024-07-22 DOI: 10.23736/S0026-4806.24.09388-1

Yu Yang, Hui Huang, Lei Xu, Zudan Zhou, Li Yang, Liling Xie, Xia Shuai, Ka Chen

引用次数: 0

Diagnostic efficiency and safety evaluation of different groups of lymph nodes in 193 cases of conventional transbronchial needle aspiration (C-TBNA). 对 193 例常规经支气管针吸术（C-TBNA）中不同组别淋巴结的诊断效率和安全性进行评估。

Minerva medica Pub Date : 2024-07-22 DOI: 10.23736/S0026-4806.24.09330-3

Yeshan Li, Ling Lin, Zhaoyan Wu, Fangfang Bai, Yao Lu, Gang Yang, Shirong Li

引用次数: 0

Reappraisal of Pidotimod: an immunomodulatory agent with 30-year evidence. 重新评估匹多莫德：一种经过 30 年验证的免疫调节药物。

Minerva medica Pub Date : 2024-07-17 DOI: 10.23736/S0026-4806.24.09391-1

Gian L Marseglia, Matteo Gelardi, Pierachille Santus, Giorgio Ciprandi

{"title":"Reappraisal of Pidotimod: an immunomodulatory agent with 30-year evidence.","authors":"Gian L Marseglia, Matteo Gelardi, Pierachille Santus, Giorgio Ciprandi","doi":"10.23736/S0026-4806.24.09391-1","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09391-1","url":null,"abstract":"Pidotimod (3-L-pyroglutamyl-L-thiaziolidine-4-carboxylic acid) is a synthetic dipeptide with immunomodulatory properties that is indicated for use in adults and children over 3 years of age with documented cell-mediated immunodepression during respiratory and urinary tract infections. Infections are associated with an immune response that helps fight pathogens. In this scenario, inflammatory events occur to improve the antimicrobial reaction. However, defective immunity and/or sustained inflammation may adversely affect the course of the infection. Thus, modulating immune function could be a valuable option in managing patients with infections. The multifaceted mechanism of action of Pidotimod enables it to modulate innate and adaptive immunity. Extensive evidence about Pidotimod, accumulated over the last 30 years, has provided much data on the prevention of recurrent respiratory infections in susceptible children and respiratory exacerbations in patients with chronic bronchitis. Recent studies provide interesting information on how Pidotimod affects the metabolomic profiles of patients with bronchiectasis, clinical and immunological outcomes of elderly patients with pneumonia, clinical and cellular changes in patients with allergic rhinitis and asthma, and beneficial effects on cytokines and humoral immunity in human immunodeficiency virus (HIV) patients. Preliminary experience suggests that Pidotimod can shorten the duration of COVID-19 infection and reduce clinical severity by modulating the immune response, as well as prevent vaccination-related adverse events. In conclusion, the immunomodulatory properties of Pidotimod indicate that it may be a valuable option in managing patients with respiratory infections and other immune-mediated disorders, including allergy, chronic obstructive pulmonary disease, and asthma.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary hypertension in patients affected by sleep-related breathing disorders: up to date from the literature. 睡眠呼吸障碍患者的肺动脉高压：最新文献。

Minerva medica Pub Date : 2024-07-17 DOI: 10.23736/S0026-4806.24.09112-2

Elvia Battaglia, Elena Compalati, Luca Mapelli, Agata Lax, Paola Pierucci, Paolo Solidoro, Paolo Banfi

{"title":"Pulmonary hypertension in patients affected by sleep-related breathing disorders: up to date from the literature.","authors":"Elvia Battaglia, Elena Compalati, Luca Mapelli, Agata Lax, Paola Pierucci, Paolo Solidoro, Paolo Banfi","doi":"10.23736/S0026-4806.24.09112-2","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09112-2","url":null,"abstract":"Sleep-related breathing disorders (SBD) are conditions of abnormal and difficult respiration during sleep, including chronic snoring, obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation disorders and sleep-related hypoxemia. Some of them have a limited impact on health, but others (e.g., OSA) can have serious consequences, because of their dangerous effects on sleep and the hematic balance of oxygen and carbon dioxide. According to several population-based studies, prevalence of OSA is relatively high, approximately 3-7% for adult males and 2-5% for adult females in the general population. However, methodological differences and difficulties in characterizing this syndrome yielded to variability in estimates. Moreover, it is estimated that only about 40% of patients with OSA are diagnosed, which can lead to underestimation of disease prevalence. OSA is directly correlated with age and male sex and to risk factors such as obesity. Several studies found that OSA is associated with an increased risk of diabetes, some cancer types, cardiovascular and cerebrovascular diseases, such as hypertension, coronary artery disease and stroke. Pulmonary hypertension (PH), a noted cardiovascular disease, is significantly associated with sleep-related breathing disorders and lot of scientific studies published in the literature demonstrated a strong link between these conditions and the development of pulmonary hypertension PH. PH is relatively less common than sleep-related breathing disorders. The purpose of this systematic review is to analyze both the current knowledge around the consequences that SBD may have on pulmonary hemodynamics and the effects resulting from pharmacological and non-pharmacological treatments of SDB on PH.","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0