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Can we predict the natural evolution of probiotics? 我们能否预测益生菌的自然进化？
Minerva medica Pub Date : 2024-10-01 Epub Date: 2024-09-12 DOI: 10.23736/S0026-4806.24.09568-5
Francesco DI Pierro
{"title":"Can we predict the natural evolution of probiotics?","authors":"Francesco DI Pierro","doi":"10.23736/S0026-4806.24.09568-5","DOIUrl":"10.23736/S0026-4806.24.09568-5","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol-related diseases: from metabolism to the main effect on the body. 与酒精有关的疾病：从新陈代谢到对身体的主要影响。
Minerva medica Pub Date : 2024-10-01 Epub Date: 2024-06-13 DOI: 10.23736/S0026-4806.24.09355-8
Fabio Caputo, Lisa Lungaro, Matteo Guarino, Anna Costanzini, Giacomo Caio, Gianni Testino, Roberto DE Giorgio
{"title":"Alcohol-related diseases: from metabolism to the main effect on the body.","authors":"Fabio Caputo, Lisa Lungaro, Matteo Guarino, Anna Costanzini, Giacomo Caio, Gianni Testino, Roberto DE Giorgio","doi":"10.23736/S0026-4806.24.09355-8","DOIUrl":"10.23736/S0026-4806.24.09355-8","url":null,"abstract":"<p><p>Alcohol consumption can cause, beyond addiction, roughly 200 different diseases and at least fourteen types of cancer. In 2016 the WHO estimated that 29% of alcohol-related deaths were mainly due to oncological diseases, liver cirrhosis (20%), and cardiovascular disorders (19%). The aim of this review was to focus on the absorption and metabolism of ethanol and discuss the main conditions caused by alcohol consumption (i.e., liver and cardiovascular diseases, and tumors). This narrative review is based on a detailed analysis of the scientific literature published before January 31, 2024 (PubMed, Web of Science, Scopus, Google Scholar). Approximately 90% of the absorbed alcohol reaches the liver where it is metabolized to acetaldehyde, a highly reactive and toxic compound. The excessive use of alcohol causes damage to several organs and systems, mainly the liver (e.g., steatosis, steato-hepatitis, fibrosis, and cirrhosis), cardiovascular system (cardiomyopathy, arrythmias, arterial hypertension, and stroke), and significantly contribute to the onset of neoplastic lesions to various organs including the esophagus, liver and breast. Even moderate drinking appears not to reduce mortality risk. Alcohol intake is one of the main risk factors for several pathological conditions and social problems, thus drastically impacting on public health. Proper awareness of the high risk related to alcohol consumption is of crucial importance to reduce the harm to public health.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current treatment paradigms for triple-negative breast cancer. 目前治疗三阴性乳腺癌的范例。
Minerva medica Pub Date : 2024-10-01 Epub Date: 2024-07-17 DOI: 10.23736/S0026-4806.24.09458-8
Sumeet K Yadav, Roberto A Leon-Ferre
{"title":"Current treatment paradigms for triple-negative breast cancer.","authors":"Sumeet K Yadav, Roberto A Leon-Ferre","doi":"10.23736/S0026-4806.24.09458-8","DOIUrl":"10.23736/S0026-4806.24.09458-8","url":null,"abstract":"<p><p>Triple negative breast cancer (TNBC) accounts for 15% of all breast cancers and is characterized by more aggressive biology, significant disease heterogeneity, and worse clinical outcomes. In recent years, improved understanding of TNBC tumor biology and its heterogeneity have led to the identification of new molecular targets, opening avenues for novel treatment strategies. Clinical trials evaluating immunotherapy, poly-ADP ribose polymerase (PARP) inhibitors, and antibody drug conjugates have shown improvement in clinical outcomes, leading to their incorporation to the treatment options available for patients with TNBC. This review aimed to provide the internal medicine specialist and primary care provider with a comprehensive overview of the current systemic therapy approaches for TNBC and introduce clinicians to novel therapies that have recently been added to the treatment armamentarium against this disease.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nursing collaboration for minimally invasive left ventricular assist device implantation. 微创左心室辅助装置植入术的护理协作。
Minerva medica Pub Date : 2024-09-26 DOI: 10.23736/S0026-4806.24.09382-0
Mengtian Wang, Min Hong, Xu Zhang, Jintao Liu
{"title":"Nursing collaboration for minimally invasive left ventricular assist device implantation.","authors":"Mengtian Wang, Min Hong, Xu Zhang, Jintao Liu","doi":"10.23736/S0026-4806.24.09382-0","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09382-0","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research on DRGs payment system in TCM medical institutions by taking chronic hepatitis B of TCM single disease as an example. 以中医单病种慢性乙型肝炎为例，研究中医医疗机构 DRGs 支付制度。
Minerva medica Pub Date : 2024-09-26 DOI: 10.23736/S0026-4806.24.09385-6
Qian DU, Qiang Huang, Liang Chen, Chunming Wu, Sanhai Liu
{"title":"Research on DRGs payment system in TCM medical institutions by taking chronic hepatitis B of TCM single disease as an example.","authors":"Qian DU, Qiang Huang, Liang Chen, Chunming Wu, Sanhai Liu","doi":"10.23736/S0026-4806.24.09385-6","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09385-6","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical approach to the diagnosis and management of small bowel bleeding. 诊断和处理小肠出血的临床方法。
Minerva medica Pub Date : 2024-09-26 DOI: 10.23736/S0026-4806.24.09361-3
Sanket Bhattarai, Sandra Algarin Perneth, Huber Padilla Zambrano, Cadman L Leggett
{"title":"Clinical approach to the diagnosis and management of small bowel bleeding.","authors":"Sanket Bhattarai, Sandra Algarin Perneth, Huber Padilla Zambrano, Cadman L Leggett","doi":"10.23736/S0026-4806.24.09361-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09361-3","url":null,"abstract":"<p><p>The diagnosis and management of small bowel bleeding (SBB) can be a clinical challenge. Advances in video capsule endoscopy, balloon-assisted enteroscopy, and multiphasic computed tomography allow for localization and therapeutic intervention. Etiologies of SBB including vascular, neoplastic, and inflammatory conditions are associated with age and comorbidities. The present review highlights terminologies that describe SBB, provides a differential diagnosis for bleeding etiologies, and summarizes a clinical approach to managing this condition.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High prevalence of intimate partner violence in outpatient women addressed for hematological investigations. 在接受血液学检查的门诊妇女中，亲密伴侣暴力的发生率很高。
Minerva medica Pub Date : 2024-09-18 DOI: 10.23736/S0026-4806.24.09466-7
Chloé Bourguignon, Jérémy Laurent, Géraldine Lissade-Lavigne, Mathias Chea, Jean-Christophe Gris
{"title":"High prevalence of intimate partner violence in outpatient women addressed for hematological investigations.","authors":"Chloé Bourguignon, Jérémy Laurent, Géraldine Lissade-Lavigne, Mathias Chea, Jean-Christophe Gris","doi":"10.23736/S0026-4806.24.09466-7","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09466-7","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The accuracy of cervical lymph node puncture biopsy and angiography in the early diagnosis of head and neck cancer. 宫颈淋巴结穿刺活检和血管造影在头颈癌早期诊断中的准确性。
Minerva medica Pub Date : 2024-09-18 DOI: 10.23736/S0026-4806.24.09404-7
Youzhen Shi, Ping Xiong
{"title":"The accuracy of cervical lymph node puncture biopsy and angiography in the early diagnosis of head and neck cancer.","authors":"Youzhen Shi, Ping Xiong","doi":"10.23736/S0026-4806.24.09404-7","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09404-7","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translation, cross-cultural adaptation, and validation of the Italian version of the Parkinson's disease caregiver burden questionnaire (PDCB-I). 意大利语版帕金森病护理者负担问卷 (PDCB-I) 的翻译、跨文化改编和验证。
Minerva medica Pub Date : 2024-09-18 DOI: 10.23736/S0026-4806.24.09494-1
Sara Gherardini, Elena Porri, Matilde Dugini, Valentina Santoro, Matteo Paci
{"title":"Translation, cross-cultural adaptation, and validation of the Italian version of the Parkinson's disease caregiver burden questionnaire (PDCB-I).","authors":"Sara Gherardini, Elena Porri, Matilde Dugini, Valentina Santoro, Matteo Paci","doi":"10.23736/S0026-4806.24.09494-1","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09494-1","url":null,"abstract":"<p><strong>Background: </strong>To translate and cross-culturally adapt the Parkinson's Disease Caregiver Burden questionnaire (PDBC) into Italian language and to evaluate the psychometric properties of the Italian version in terms of test-retest reliability, internal consistency, and construct validity.</p><p><strong>Methods: </strong>The PDBC-I was developed by forward-backward translation to establish correspondence with the original English latest version. Psychometric properties were estimated in a sample of primary caregivers of individuals with Parkinson's disease. Reliability testing included internal consistency (Cronbach's alpha), test-retest reliability (ICC), the standard error of measurement (SEM) and the minimal detectable change (MDC), also expressed as percentage (MDC%). Validity was estimated by comparing the PDBC -I to the Caregiver Burden Inventory (CBI) and the Short Form 36 (SF-36) (Pearson correlation coefficient).</p><p><strong>Results: </strong>The questionnaire was administered to 65 caregivers, showing internal consistency of 0.934. ICC value was 0.811 (95% CI 0.708-0.880) for test-retest reliability, and the SEM and the MDC (MDC%) were 5.04 and 13.97 (38.21%), respectively. Low to moderate correlation with all other investigated scales (CBI: r=0.693; SF-36 physical score: r=-0.309; SF-36 mental score: r=-0.588; SF36 total score: -0.470) were found.</p><p><strong>Conclusions: </strong>Despite the PDCB-I holds acceptable psychometric properties to be used in clinical settings of Italian-speaking Countries as a measure of caregiver burden in caregivers of individuals with Parkinson Disease, the caregiver might require the support of a clinician to finalize the compilation of the questionnaire.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the therapeutic effect of Qishen Qiangxin formula combined with Sacubitril Valsartan sodium tablets on patients with chronic heart failure. 芪参羌活方联合沙库比特利缬沙坦钠片对慢性心力衰竭患者的治疗效果研究。
Minerva medica Pub Date : 2024-09-18 DOI: 10.23736/S0026-4806.24.09478-3
Ru He, Yuepeng Yuan, Yang Bai, Dong Li
{"title":"Study on the therapeutic effect of Qishen Qiangxin formula combined with Sacubitril Valsartan sodium tablets on patients with chronic heart failure.","authors":"Ru He, Yuepeng Yuan, Yang Bai, Dong Li","doi":"10.23736/S0026-4806.24.09478-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09478-3","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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