Minerva medicaPub Date : 2024-10-01Epub Date: 2024-07-04DOI: 10.23736/S0026-4806.24.09291-7
Stefano Moretto, Michele Zazzara, Filippo Marino, Arjan Nazaraj, Marcello Scarcia, Giuseppe M Ludovico
{"title":"Robotic pyelolithotomy for the treatment of large renal stones: a single-center experience over seven years.","authors":"Stefano Moretto, Michele Zazzara, Filippo Marino, Arjan Nazaraj, Marcello Scarcia, Giuseppe M Ludovico","doi":"10.23736/S0026-4806.24.09291-7","DOIUrl":"10.23736/S0026-4806.24.09291-7","url":null,"abstract":"<p><strong>Background: </strong>Urolithiasis prevalence varies globally between 1-20%, influenced by regional factors. Robotic pyelolithotomy (RPL) presents an interesting alternative to PCNL, considered the gold standard for symptomatic stones smaller than 20 mm, as it carries a risk of significant complications. However, studies on RPL are limited, especially in anatomically complex cases, where RPL proves to be particularly useful. The study aims to update and review outcomes of RPL in a high-volume robotic center.</p><p><strong>Methods: </strong>A retrospective analysis of 153 patients treated with RPL for staghorn kidney stones at a single center from February 2016 to December 2023 was conducted. Data including demographics, preoperative renal function, stone characteristics, operative and postoperative outcomes, and costs were collected. Stone-free rates (SFR) and complications were assessed at follow-up intervals up to 12 months post-surgery.</p><p><strong>Results: </strong>The study showed an initial 3-month stone-free rate (SFR) of 93.5%, which decreased to 83.5% at 12-months. This trend may reflect new stone formation rather than procedure failure. Sub-analysis revealed a significant difference in SFR between patients with pelvic and pyelocalyceal stones at each follow-up. Multivariate regression analysis identified in the pyelocalyceal group that higher BMI and larger stones were associated with higher failure rates at both 6 and 12 months.</p><p><strong>Conclusions: </strong>RPL is a safe and effective treatment for large renal stones, offering a high SFR and low complication rate. It is particularly beneficial in cases with complex anatomy or requiring concurrent renal procedures. However, patient selection is crucial, considering factors like stone location and size. Further research is needed to compare RPL with other treatment methods.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"573-580"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-10-01Epub Date: 2024-07-02DOI: 10.23736/S0026-4806.24.09343-1
Yashendra Sethi, Oroshay Kaiwan, Giacomo Frati, Mariangela Peruzzi, Mattia Galli, Mario Gaudino, Giuseppe Biondi-Zoccai
{"title":"Exploring the landscape of academic retractions in medicine: a comprehensive umbrella review.","authors":"Yashendra Sethi, Oroshay Kaiwan, Giacomo Frati, Mariangela Peruzzi, Mattia Galli, Mario Gaudino, Giuseppe Biondi-Zoccai","doi":"10.23736/S0026-4806.24.09343-1","DOIUrl":"10.23736/S0026-4806.24.09343-1","url":null,"abstract":"<p><strong>Introduction: </strong>The escalating trend of academic article retractions over the last decades raises concerns about scientific integrity, but heterogeneity in retractions and reasons for them pose a major challenge. We aimed to comprehensively overview systematic reviews focusing on retractions in the biomedical literature.</p><p><strong>Evidence acquisition: </strong>We abstracted salient features and bibliometric details from shortlisted articles. The Joanna Briggs Institute (JBI) Checklist for Systematic Reviews and Research Syntheses was used for validity appraisal.</p><p><strong>Evidence synthesis: </strong>A total of 11 reviews were included, published between 2016 and 2023, and reporting on a total of 1851 retracted studies. Several major reasons for retractions were identified, spanning both misconduct (e.g., falsification, duplication, plagiarism) and non-misconduct issues (e.g., unreliable data, publishing problems). Correlates include author-related factors (number of authors, nationality) and journal-related factors (impact factor), with repeat offenders contributing significantly. Impacts of retractions is profound, affecting scholarly credibility, public trust, and resource utilization.</p><p><strong>Conclusions: </strong>In order to prevent retractions and amend their adverse effects, rigorous and transparent reporting standards, enhanced training in research ethics, strengthened peer review processes, and the establishment of collaborative and integrated research integrity offices are proposed.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"581-588"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-10-01DOI: 10.23736/S0026-4806.24.09552-1
Ignazio LA Mantia, Attilio Varricchio, Cristina Luceri, Giorgio Ciprandi
{"title":"Reflux disease: a new multicomponent solution for a multifaceted problem.","authors":"Ignazio LA Mantia, Attilio Varricchio, Cristina Luceri, Giorgio Ciprandi","doi":"10.23736/S0026-4806.24.09552-1","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09552-1","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":"115 5","pages":"529-532"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-10-01Epub Date: 2024-09-12DOI: 10.23736/S0026-4806.24.09568-5
Francesco DI Pierro
{"title":"Can we predict the natural evolution of probiotics?","authors":"Francesco DI Pierro","doi":"10.23736/S0026-4806.24.09568-5","DOIUrl":"10.23736/S0026-4806.24.09568-5","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"614-616"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-10-01Epub Date: 2024-06-13DOI: 10.23736/S0026-4806.24.09355-8
Fabio Caputo, Lisa Lungaro, Matteo Guarino, Anna Costanzini, Giacomo Caio, Gianni Testino, Roberto DE Giorgio
{"title":"Alcohol-related diseases: from metabolism to the main effect on the body.","authors":"Fabio Caputo, Lisa Lungaro, Matteo Guarino, Anna Costanzini, Giacomo Caio, Gianni Testino, Roberto DE Giorgio","doi":"10.23736/S0026-4806.24.09355-8","DOIUrl":"10.23736/S0026-4806.24.09355-8","url":null,"abstract":"<p><p>Alcohol consumption can cause, beyond addiction, roughly 200 different diseases and at least fourteen types of cancer. In 2016 the WHO estimated that 29% of alcohol-related deaths were mainly due to oncological diseases, liver cirrhosis (20%), and cardiovascular disorders (19%). The aim of this review was to focus on the absorption and metabolism of ethanol and discuss the main conditions caused by alcohol consumption (i.e., liver and cardiovascular diseases, and tumors). This narrative review is based on a detailed analysis of the scientific literature published before January 31, 2024 (PubMed, Web of Science, Scopus, Google Scholar). Approximately 90% of the absorbed alcohol reaches the liver where it is metabolized to acetaldehyde, a highly reactive and toxic compound. The excessive use of alcohol causes damage to several organs and systems, mainly the liver (e.g., steatosis, steato-hepatitis, fibrosis, and cirrhosis), cardiovascular system (cardiomyopathy, arrythmias, arterial hypertension, and stroke), and significantly contribute to the onset of neoplastic lesions to various organs including the esophagus, liver and breast. Even moderate drinking appears not to reduce mortality risk. Alcohol intake is one of the main risk factors for several pathological conditions and social problems, thus drastically impacting on public health. Proper awareness of the high risk related to alcohol consumption is of crucial importance to reduce the harm to public health.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"599-613"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-10-01Epub Date: 2024-07-17DOI: 10.23736/S0026-4806.24.09458-8
Sumeet K Yadav, Roberto A Leon-Ferre
{"title":"Current treatment paradigms for triple-negative breast cancer.","authors":"Sumeet K Yadav, Roberto A Leon-Ferre","doi":"10.23736/S0026-4806.24.09458-8","DOIUrl":"10.23736/S0026-4806.24.09458-8","url":null,"abstract":"<p><p>Triple negative breast cancer (TNBC) accounts for 15% of all breast cancers and is characterized by more aggressive biology, significant disease heterogeneity, and worse clinical outcomes. In recent years, improved understanding of TNBC tumor biology and its heterogeneity have led to the identification of new molecular targets, opening avenues for novel treatment strategies. Clinical trials evaluating immunotherapy, poly-ADP ribose polymerase (PARP) inhibitors, and antibody drug conjugates have shown improvement in clinical outcomes, leading to their incorporation to the treatment options available for patients with TNBC. This review aimed to provide the internal medicine specialist and primary care provider with a comprehensive overview of the current systemic therapy approaches for TNBC and introduce clinicians to novel therapies that have recently been added to the treatment armamentarium against this disease.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"589-598"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-09-26DOI: 10.23736/S0026-4806.24.09385-6
Qian DU, Qiang Huang, Liang Chen, Chunming Wu, Sanhai Liu
{"title":"Research on DRGs payment system in TCM medical institutions by taking chronic hepatitis B of TCM single disease as an example.","authors":"Qian DU, Qiang Huang, Liang Chen, Chunming Wu, Sanhai Liu","doi":"10.23736/S0026-4806.24.09385-6","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09385-6","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical approach to the diagnosis and management of small bowel bleeding.","authors":"Sanket Bhattarai, Sandra Algarin Perneth, Huber Padilla Zambrano, Cadman L Leggett","doi":"10.23736/S0026-4806.24.09361-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09361-3","url":null,"abstract":"<p><p>The diagnosis and management of small bowel bleeding (SBB) can be a clinical challenge. Advances in video capsule endoscopy, balloon-assisted enteroscopy, and multiphasic computed tomography allow for localization and therapeutic intervention. Etiologies of SBB including vascular, neoplastic, and inflammatory conditions are associated with age and comorbidities. The present review highlights terminologies that describe SBB, provides a differential diagnosis for bleeding etiologies, and summarizes a clinical approach to managing this condition.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}