Minerva medica最新文献

{"title":"Role of artificial intelligence in cognitive debiasing within clinical decision-making.","authors":"Giovanni Volpe, Andrea Zanoni","doi":"10.23736/S0026-4806.25.09831-3","DOIUrl":"10.23736/S0026-4806.25.09831-3","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"504-505"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study of the venous structure and hemodynamic status of patients with varicose veins of the lower limbs by bifunctional ultrasound scanning.","authors":"Ying Gao, Minghui Sun, Junming Qin, Xin Wang","doi":"10.23736/S0026-4806.24.09105-5","DOIUrl":"10.23736/S0026-4806.24.09105-5","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"510-513"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amoxicillin/clavulanate as a cornerstone of antibiotic stewardship: integrating WHO AWaRe principles, Italian recommendations, and evidence-based practice.","authors":"Roberto Mattina, Francesco Scaglione","doi":"10.23736/S0026-4806.25.09808-8","DOIUrl":"10.23736/S0026-4806.25.09808-8","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) remains a critical global health concern, largely driven by inappropriate antibiotic use. To address this challenge, the World Health Organization (WHO) developed the AWaRe (Access, Watch, Reserve) classification, prioritizing the use of Access antibiotics - narrow-spectrum agents with proven efficacy and low resistance potential. Amoxicillin/clavulanate, included in the Access group, is widely endorsed in international and national guidelines, as a first-line option for common community-acquired infections. This Expert Opinion reviews the positioning of amoxicillin/clavulanate within stewardship frameworks, synthesizing its pharmacological characteristics, clinical evidence, and relevance in both Italian and global contexts. The combination of amoxicillin with the β-lactamase inhibitor clavulanic acid provides broad activity against key respiratory pathogens such as Haemophilus influenzae, and Moraxella catarrhalis, including β-lactamase-producing strains. Evidence from randomized controlled trials and meta-analyses demonstrates high bacteriological eradication and clinical cure rates across acute bacterial rhinosinusitis, otitis media, community-acquired pneumonia, and chronic bronchitis exacerbations. In pediatric populations, amoxicillin/clavulanate has shown significant efficacy in protracted bacterial bronchitis and chronic wet cough. Comparative data confirm its equivalence or superiority to macrolides and fluoroquinolones while maintaining a lower resistance selection potential and favorable tolerability. The integration of WHO AWaRe targets, Italian stewardship recommendations, and robust clinical evidence underscores the central role of amoxicillin/clavulanate in rational antibiotic prescribing. Its stewardship-aligned use - emphasizing short-course therapy, targeted prescribing, and avoidance in viral syndromes - represents a pragmatic and evidence-based strategy to optimize treatment outcomes while contributing to AMR mitigation in both national and global contexts.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"497-503"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-wave diathermy in the rehabilitation management of tension-type headache associated with neck pain: a case-control study.","authors":"Alessandro Picelli, Rita DI Censo, Diletta Lorenzoni Inama, Cecilia Angeli, Tullio Malgrati, Marta Cappellesso, Vittorio Schweiger, Alvise Martini, Valentina Varalta, Nicola Smania, Mirko Filippetti","doi":"10.23736/S0026-4806.25.09756-3","DOIUrl":"10.23736/S0026-4806.25.09756-3","url":null,"abstract":"<p><strong>Background: </strong>Tension-type headache is the most prevalent neurological disorder worldwide and is frequently associated with neck pain. Musculoskeletal dysfunctions of the cervical spine are commonly reported in patients with tension-type headache, suggesting a potential therapeutic role for physical rehabilitation. Short-wave diathermy is a deep-heating modality known to increase pain thresholds, reduce muscle spasm, and enhance soft tissue extensibility. The aim of this study was preliminary to assess the effectiveness of short-wave diathermy as an adjunct to conventional rehabilitation for adults with tension-type headache associated with neck pain.</p><p><strong>Methods: </strong>This single-center case-control observational study retrospectively analyzed data of 42 adult patients with persistent tension-type headache and neck pain were included. Cases received short-wave diathermy (20 minutes) combined with myofascial release (pompage technique, 20 minutes), while controls underwent pompage and therapeutic neck exercises (20 minutes each). All participants completed ten 45-minute sessions over five weeks. Primary outcome was pain intensity (Numerical Pain Rating Scale). Secondary outcomes included disability (Neck Disability Index) and pressure pain threshold. Assessments were conducted before and one week after treatment completion.</p><p><strong>Results: </strong>After treatment, the Case group showed significantly greater improvements compared to controls in neck pain (P=0.03) and disability (P=0.04). No significant between-group differences were observed in pressure pain threshold measurements at cervical sites.</p><p><strong>Conclusions: </strong>Preliminary findings suggest that short-wave diathermy may serve as a useful adjunct in the rehabilitation of adults with tension-type headache associated with neck pain. Larger randomized controlled studies are needed to confirm these results.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"447-453"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic approaches in the management of chronic kidney disease: the past, the present, and the future.","authors":"Georgia Doumani, Panagiotis Theofilis, Aikaterini Vordoni, Despina Smirloglou, Rigas G Kalaitzidis","doi":"10.23736/S0026-4806.25.09747-2","DOIUrl":"10.23736/S0026-4806.25.09747-2","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) remains a major global health burden, contributing significantly to morbidity, mortality, and healthcare costs. Over the past century, therapeutic approaches to CKD have evolved substantially, reflecting advances in the understanding of renal pathophysiology. Early strategies centered around dietary interventions, notably low-protein diets, aimed at mitigating the progression of renal impairment. Subsequently, rigorous blood pressure control and the introduction of renin-angiotensin-aldosterone system (RAAS) blockade with ACE inhibitors and ARBs markedly improved renal outcomes. In the modern era, the emergence of sodium-glucose cotransporter 2 (SGLT2) inhibitors, non-steroidal mineralocorticoid receptor antagonists (nsMRAs) such as finerenone, and glucagon-like peptide-1 receptor agonists (GLP-1RAs) has redefined the therapeutic landscape, offering robust cardiorenal protection. Despite these advances, CKD often remains a progressive disease, underscoring the need for continued innovation. Future therapeutic strategies, including aldosterone synthase inhibitors, soluble guanylate cyclase activators, and therapies currently in preclinical development - such as gene-editing technologies, novel peptide therapies, and renal regenerative approaches - aim to target the fundamental drivers of CKD progression. These emerging modalities hold the promise not merely of slowing disease progression but potentially restoring renal function. As the field moves toward personalized, mechanism-based interventions, early diagnosis and prompt initiation of therapy will remain pivotal. This review traces the historical evolution of CKD management, highlights contemporary advances, and explores the exciting horizon of future therapeutic opportunities.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"468-482"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strain-level resolution is needed to understand the putative pathogenic role of bacteria.","authors":"Francesco DI Pierro, Chiara M Palazzi, Alexander Bertuccioli, Nicola Zerbinati","doi":"10.23736/S0026-4806.25.09792-7","DOIUrl":"https://doi.org/10.23736/S0026-4806.25.09792-7","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":"116 6","pages":"505-507"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-like peptide-1 receptor agonists and its possible nephroprotective role: a systematic review.","authors":"Alessandro Perencin, Chiara Ceolin, Mario V Papa, Benedetta DI Marzio, Bruno M Zanforlini, Maria Devita, Chiara Curreri, Giulia Gasparini, Giuseppe Sergi, Marina DE Rui","doi":"10.23736/S0026-4806.25.09709-5","DOIUrl":"10.23736/S0026-4806.25.09709-5","url":null,"abstract":"<p><strong>Introduction: </strong>Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are commonly used to manage type 2 diabetes (T2DM), offering benefits not only for blood sugar control but also potentially for kidney health. While some studies have looked at kidney function, no review has specifically focused on how these medications impact kidney health in people with diabetes.</p><p><strong>Evidence acquisition: </strong>We conducted a review of existing studies following established guidelines. We searched databases like PubMed, Embase, Web of Science, and the Cochrane Library for studies that examined kidney outcomes - such as estimated glomerular filtration rate (eGFR) and albumin-to-creatinine ratio (ACR) - in T2DM patients treated with GLP-1RAs. We also assessed the quality of these studies using well-known bias risk tools.</p><p><strong>Evidence synthesis: </strong>We included 13 studies, including clinical trials and observational research. Overall, the findings suggest that GLP-1RAs may help slow the decline in kidney function, reduce proteinuria and improve other kidney health markers in people with T2DM. However, the results weren't consistent - some studies showed clear benefits, while others found little to no effect.</p><p><strong>Conclusions: </strong>This review highlights the potential for GLP-1RAs to protect kidney function in people with type 2 diabetes. Although the evidence is encouraging, the differences between studies suggest the need for more large-scale, well-designed trials to confirm these effects and help guide treatment decisions.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"454-460"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracorporeal cardiopulmonary resuscitation: what does the future hold for out of hospital cardiac arrest? A narrative review and critical appraisal of the literature.","authors":"Ana R Bello, Daniel A Gomes, João Presume, Catarina Brízido, Christopher Strong, António Tralhão","doi":"10.23736/S0026-4806.25.09716-2","DOIUrl":"10.23736/S0026-4806.25.09716-2","url":null,"abstract":"<p><p>The use of extracorporeal cardiopulmonary resuscitation (ECPR) has risen exponentially worldwide. Following favorable observational studies, randomized controlled trials yielded conflicting results in patients with out of hospital cardiac arrest when compared to conventional advanced life support. Additionally, several important questions remain incompletely answered, from patient selection criteria, logistics of care and post-cardiac arrest management, to cost-benefit thresholds, withdrawal of care and organ donation. We offer a narrative review of current literature, critically appraising the existing evidence and discussing pragmatic hurdles to ECPR implementation.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"483-496"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the mechanistic synergy of palmitoylethanolamide and acetyl-L-carnitine in lumbosciatalgia.","authors":"Simone Parisi","doi":"10.23736/S0026-4806.25.09763-0","DOIUrl":"10.23736/S0026-4806.25.09763-0","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"365-368"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractionated lentisk oil as add-on therapy for preventing chronic rhinosinusitis recurrence.","authors":"Francesco DI Pierro, Nicola Zerbinati, Maria L Tanda, Giulia Monti, Alberto Macchi","doi":"10.23736/S0026-4806.25.09683-1","DOIUrl":"10.23736/S0026-4806.25.09683-1","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"441-443"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}