Minerva medica最新文献

{"title":"The outcome difference of monotherapy versus combination therapy among patients with pneumonia: a systematic review.","authors":"Pande A Permatananda, Pande A Pandit","doi":"10.23736/S0026-4806.24.09446-1","DOIUrl":"10.23736/S0026-4806.24.09446-1","url":null,"abstract":"<p><strong>Introduction: </strong>Pneumonia is a severe public health problem on a global scale. Pneumonia continues to be the leading infectious disease-related cause of mortality worldwide. Selecting appropriate antimicrobial treatment is a significant challenge including multi-drug resistant bacteria. The use of monotherapy and combination therapy of antibiotics in pneumonia is still controversial. Considering the wide range of patient characteristics and illness severity in pneumonia, it is important to investigate the variables that affect mortality in different treatment plans. Therefore, this study aimed to systematically review the available evidence regarding comparing monotherapy and combination regimens in pneumonia patients.</p><p><strong>Evidence acquisition: </strong>A systematic search across various electronic databases like PubMed, Google Scholar, Proquest, and Cochrane was conducted to identify articles published from 2014 to 2024. Review papers, incomplete articles, and duplicates were excluded.</p><p><strong>Evidence synthesis: </strong>Initially, 179 articles were retrieved from the database search. After a systematic elimination process, sox pertinent articles were identified. These articles involved a total of 11,513 patients across 11 studies. All studies were conducted at single centers, comprising three retrospective cohort studies, one prospective cohort study, one randomized controlled trial, and one cross-sectional study.</p><p><strong>Conclusions: </strong>Monotherapy and combination therapy have comparable outcomes in mortality rate and hospital length of stay. However, combination therapy is linked with a lower mortality rate in immunocompromised and APACHE ≥15 patients.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"135-140"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplementation with Pycnogenol® relieves symptoms of chronic inflammatory diseases with a significant vasculitis component: a pilot registry study.","authors":"Gianni Belcaro, Shu Hu, Maria R Cesarone, Valeria Scipione, Claudia Scipione, Mark Dugall, Umberto Cornelli, David Cox, Morio Hosoi, Beatrice Feragalli, Francesca Coppazuccari, Roberto Cotellese","doi":"10.23736/S0026-4806.24.09579-X","DOIUrl":"10.23736/S0026-4806.24.09579-X","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the potential use of a food supplement, Pycnogenol^® (French maritime Pine Bark Extract) as an anti-inflammatory management during the remission phases of four conditions with a vasculitis component: systemic lupus erythematosus, Behçet's disease, Sjögren Syndrome and polyarteritis nodosa. Symptoms were minimal but persisting and the subjects did not use any chronic drug treatment.</p><p><strong>Methods: </strong>The aim of this pilot registry study was to evaluate the safety and the preventive effects of oral Pycnogenol^® on the residual symptoms of the inflammatory conditions and possible effects on the recurrence of symptoms in a 4-week, open, supplement registry study.</p><p><strong>Results: </strong>The registry study included 124 otherwise healthy subjects, suffering from one of the vasculitis conditions with 63 patients taking Pycnogenol^® 150 mg per day and 61 serving as controls. There were no dropouts. Symptom distribution was comparable in the control and in the supplement groups at baseline. No side effects of Pycnogenol^® supplementation were observed. The symptom scores that ranged from 0 to 10, decreased significantly in all the Pycnogenol^® groups after 4 weeks compared to controls (P<0.05). After 4 weeks ESR values decreased significantly in all Pycnogenol^® groups compared to controls (P<0.05). The proportion of subjects with high IL-6 (>5.9 pg/mL) decreased significantly after 4 weeks in the Pycnogenol^® group compared to controls. The proportion of subjects that needed to take nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to relieve signs and symptoms was significantly lower across all Pycnogenol^® subjects at 4 weeks compared to controls. Finally, plasma oxidative stress (high, >300 Carr Units, in all subjects at inclusion) was significantly reduced (P<0.05) in the supplemented subjects, with minimal improvements in the control groups.</p><p><strong>Conclusions: </strong>In conclusion, supplementation with Pycnogenol^® may offer advantages and management possibilities for patients with vasculitis diseases allowing to avoid more potentially dangerous drug treatments. Considering a prolonged course, it is possible that chronic management with Pycnogenol^® may prevent the recurrence of diseases with a vasculitis component to clinically significant levels.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"106-112"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in oncolytic and immunotherapy of measles virus.","authors":"Yongping He, Xue Zhou, Ye Liu, Zhixu He","doi":"10.23736/S0026-4806.25.09447-9","DOIUrl":"https://doi.org/10.23736/S0026-4806.25.09447-9","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractionated lentisk oil as add-on therapy for preventing chronic rhinosinusitis recurrence.","authors":"Francesco DI Pierro, Nicola Zerbinati, Maria L Tanda, Giulia Monti, Alberto Macchi","doi":"10.23736/S0026-4806.25.09683-1","DOIUrl":"https://doi.org/10.23736/S0026-4806.25.09683-1","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical approach to the diagnosis and management of small bowel bleeding.","authors":"Sanket Bhattarai, Sandra Algarin Perneth, Huber Padilla Zambrano, Cadman L Leggett","doi":"10.23736/S0026-4806.24.09361-3","DOIUrl":"10.23736/S0026-4806.24.09361-3","url":null,"abstract":"<p><p>The diagnosis and management of small bowel bleeding (SBB) can be a clinical challenge. Advances in video capsule endoscopy, balloon-assisted enteroscopy, and multiphasic computed tomography allow for localization and therapeutic intervention. Etiologies of SBB including vascular, neoplastic, and inflammatory conditions are associated with age and comorbidities. The present review highlights terminologies that describe SBB, provides a differential diagnosis for bleeding etiologies, and summarizes a clinical approach to managing this condition.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"31-42"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous thromboembolism during pregnancy and postpartum period: an updated review.","authors":"Sanaullah Mojaddedi, Javairia Jamil, Andrew Abraham, Dawood Jamil, Hend Mansoor, Islam Y Elgendy","doi":"10.23736/S0026-4806.24.09242-5","DOIUrl":"10.23736/S0026-4806.24.09242-5","url":null,"abstract":"<p><p>Venous thromboembolism (VTE) is a leading cause of maternal mortality. The risk of VTE in pregnant and postpartum women is ~ five times higher compared with non-pregnant women. There is a physiological tendency to a hypercoagulable state, from conception to the postpartum period. Several non-obstetric risk factors independently increase the risk of VTE. Since most signs and symptoms of VTE might mimic those of a normal pregnancy, a high index of suspicion is warranted to establish the diagnosis. D-dimer, ultrasonography and computed tomography pulmonary angiography are the primary tools for VTE diagnosis. Management mainly revolves around systemic anticoagulation with heparin. Advanced therapy options exist, but these can be considered for selected high-risk cases.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"62-74"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flying to high-altitude destinations.","authors":"Johannes Burtscher, Hannes Gatterer, David Niederseer, Karin Vonbank, Martin Burtscher","doi":"10.23736/S0026-4806.24.09286-3","DOIUrl":"10.23736/S0026-4806.24.09286-3","url":null,"abstract":"<p><p>Every year millions of people fly to high-altitude destinations. They thereby expose themselves to specific high-altitude conditions. The hypoxic environment (low ambient oxygen availability) constitutes a major factor affecting health and well-being at high altitude. While the oxygen availability is already moderately reduced inside the aircraft cabin, this reduction becomes aggravated when leaving the plane at high-altitude destinations. Especially if not pre-acclimatized, the risk of suffering from high-altitude illnesses, e.g., acute mountain sickness, high-altitude cerebral or pulmonary edema, increases with the level of altitude. In addition, diminished oxygen availability impairs exercise tolerance, which not only limits physical activity at high altitude but may also provoke symptomatic exacerbation of pre-existing diseases. Moreover, the cold and dry ambient air and increased levels of solar radiation may contribute to adverse health effects at higher altitude. Thus, medical pre-examination and pre-flight advice, and proper preparation (pre-acclimatization, exercise training, and potentially adaptation of pharmacological regimes) are of utmost importance to reduce negative health impacts and frustrating travel experiences.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"43-61"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The \"Burden of Skin Diseases\" Project: a population-based study on 44,689 participants from 27 European countries.","authors":"Carle Paul, Alexander J Stratigos, Tamar Nijsten, Paolo Gisondi, Carmen Salavastru, Martin Röecken, Charles Taieb, Francesca Sampogna, Myrto Trakatelli, Luis Puig, Marie A Richard","doi":"10.23736/S0026-4806.24.09262-0","DOIUrl":"10.23736/S0026-4806.24.09262-0","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"81-83"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140924115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity of the Italian version of the Caregiver Priorities and Child Health Index of Life with Disabilities in children with cerebral palsy.","authors":"Federica Giorgi, Nicolò Sproccati, Corrado Zenesini, Francesca R Pulvirenti, Nicoletta Battisti, Nadia Sommella, Alessandra Feliciangeli, Antonella Cersosimo","doi":"10.23736/S0026-4806.24.09537-5","DOIUrl":"10.23736/S0026-4806.24.09537-5","url":null,"abstract":"<p><strong>Background: </strong>The Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD™) questionnaire is a reliable indirect indicator of functional, health status and quality of life in children with severe Cerebral Palsy (CP), as well as the caregiving burden. The aim of the study is to validate the Italian translation of Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD™) questionnaire and assess its reliability and validity.</p><p><strong>Methods: </strong>A cross-sectional study was conducted. The study involved 60 caregivers of children with CP, classified according to the Gross Motor Function Classification System (GMFCS) levels I-V. There was a self-compilation of the CPCHILD™ by primary caregivers during the clinical visit and a re-administration of the questionnaire 2-3 weeks after the first to a defined sample (N.=30, GMFCS IV-V). The Italian version of CPCHILD™'s psychometric properties were evaluated through internal consistency, test-retest reliability, and validity analyses.</p><p><strong>Results: </strong>The translated CPCHILD™ questionnaire showed excellent test-retest reliability (Intraclass Correlation Coefficient - ICC=0.97) across most sections, with significant construct validity, differentiating well between the various GMFCS levels. The internal consistency was robust (Cronbach's alpha=0.852) except for the health section. The face validity indicated high relevance of the questionnaire items to the caregivers, particularly in emotional well-being and social interaction.</p><p><strong>Conclusions: </strong>The Italian version of CPCHILD™ questionnaire is a reliable and valid tool for assessing the quality of life in children with severe CP, offering insights into the care burden and health status impacts perceived by caregivers.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":"22-30"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the language of chronic pain stories through a Facebook page. A qualitative study on narratives and unmet needs.","authors":"Maria Giulia Marini, Alessandro Braga, Chiara Lattuada, Antonietta Cappuccio, Fabio Bianco Madau","doi":"10.23736/S0026-4806.24.09577-6","DOIUrl":"10.23736/S0026-4806.24.09577-6","url":null,"abstract":"<p><strong>Background: </strong>Dimensione Sollievo (Dimension of Relief) and its Facebook page represent a patient-centered social media initiative focused on chronic pain. This platform provides users with accurate resources on chronic pain and offers a virtual space for peer interaction - a crucial aspect for a condition often lacking proper recognition. The study's primary objective was to analyze the content in relation to unmet needs, with a secondary objective to explore the role of narrative medicine (NM) in this form of social communication.</p><p><strong>Methods: </strong>Posts, replies, and comments from the Facebook page between 2020 and 2023 were analyzed using thematic frameworks such as Frank, Kleinmann, Launer classifications, and Berne's transactional analysis. Language styles, semantics, word frequency, and metaphors were also examined. Narratives were analyzed through Nvivo software and Microsoft Office tools.</p><p><strong>Results: </strong>Users embraced the Facebook page as a safe space for interaction, where they found understanding and connection, unlike their experiences outside the community. While interactions were generally brief, they intensified around issues where users perceived injustices, such as the lack of recognition of their condition by medical professionals and family, and challenges in accessing benefits. Thematic analysis revealed that the most prominent theme was the dimension of disease, with many narratives expressing difficulty coping and a lack of progress.</p><p><strong>Conclusions: </strong>The application of narrative medicine (NM) tools highlights both explicit and unconscious patient needs, such as the desire to be heard and acknowledged. This study is the first to explore NM's potential in chronic pain. Implementing NM tools through informed moderation could transform pain management culture, improving treatment approaches and enhancing the overall community experience.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":"116 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}