Medical archives (Sarajevo, Bosnia and Herzegovina)最新文献

{"title":"Burden of Delayed Circumcision on Healthcare Systems: a Retrospective Study.","authors":"Ossamah Alsowayan","doi":"10.5455/medarh.2024.78.302-304","DOIUrl":"10.5455/medarh.2024.78.302-304","url":null,"abstract":"<p><strong>Background: </strong>Circumcision is a surgical procedure that is performed for a variety of cultural, medical, and religious purposes. Carbonic Circumcision is a surgical procedure which has the potential to be performed in a public health setting and offers several advantages particularly in the prevention of disease.</p><p><strong>Objective: </strong>This study aims to evaluate the financial, medical, and sociodemographic impacts of delayed circumcision as compared to early circumcision.</p><p><strong>Methods: </strong>This retrospective study was carried after obtaining IRB approval from our institution (IRB-2024-01-814). Records of circumcision cases from January 2020 to January 2024 were reviewed comparing early circumcisions (within the first 90 days of life) done under local anesthesia with delayed circumcisions (after 180 days of life) done under general anesthesia.</p><p><strong>Results: </strong>A total of 192 patients were excluded due to various reasons: Hypospadias (57 cases), ambiguous genitalia with bilateral undescended testes (26 cases), penile web (22 cases), buried penis (12 cases), penoscrotal transposition (4 cases), and other systemic abnormalities (7 cases). Studies have shown multiple long term economic benefits when circumcision is done early on in life. The cost of circumcision performed later in life is relatively higher than that performed early. In older children, circumcision requires general anesthesia, hospital bed utilization and post operative care which significantly increases the direct cost of the procedure compared to a procedure that is done in an outpatient setting under local anesthesia.</p><p><strong>Conclusion: </strong>Delayed circumcision translates into expedited healthcare costs while circumcising neonates fosters more overall affordable and less risky surgery. Appropriate measures should be taken from the side of the decision makers in order to endorse neonatal circumcision practices during such interventions where there is a disparity in healthcare equity, costs or patient outcomes..</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 4","pages":"302-304"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex Presentation of Seatbelt Syndrome.","authors":"Naif Alkhaldi, Sadeem Aljaman, Rahaf Alghamdi, Faten Al Aqeel, Mamon Nabri, Ayman Nasr, Humood Al Sadery, Saleh Busbait","doi":"10.5455/medarh.2024.78.244-246","DOIUrl":"10.5455/medarh.2024.78.244-246","url":null,"abstract":"<p><strong>Background: </strong>Seat belt usage can lead to injuries like the \"Seat-belt sign,\" an abdominal bruising from compression forces. When coupled with internal or lumbar injuries, this forms \"Seat Belt Syndrome.</p><p><strong>Objective: </strong>This report details the case of a young male involved in a frontal collision, presenting with severe multiple complicated injuries including abdominal trauma with multiple damage control surgeries.</p><p><strong>Case presentation: </strong>The patient presented to the emergency department after road traffic accident with a seat belt sign, Exploratory laparotomy unveiled extensive injuries, including complete jejunal transaction, avulsion of the terminal ileum, sigmoid mesentery avulsion, and rectosigmoid junction degloving with left anterolateral muscle destruction forming a traumatic hernia. Surgical interventions included jejunal resection and anastomosis, ileocecal limited resection and anastomosis, lastly Hartmann procedure and left high colostomy creation. Subsequent procedures addressed complications, in form of anastomotic leakage managed with resection of the ileocolic anastomosis and ileostomy creation, Vacuum-Assisted Closure dressing, and biological mesh placement to manage abdominal wall infection and dehiscence. After one year the patient underwent surgery for ileostomy and colostomy reversal, along with abdominal wall reconstruction using biosynthetic mesh.</p><p><strong>Conclusion: </strong>Managing injuries involving the jejunum, ileum, and rectosigmoid requires careful surgical intervention, considering individual cases and surgeon judgment. Our experience highlights the need for a modification in the emergency room policies, advocating immediate computed tomography scans for patients with seat belt signs for early detection and improved outcomes.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 3","pages":"244-246"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel TSHR Gene Mutation in a Family with Non-autoimmune Hyperthyroidism.","authors":"Tamara Kufoof, Catherine Luxford, Kishani Kannangara, Roderick Clifton-Bligh, Kim C Donaghue","doi":"10.5455/medarh.2024.78.154-158","DOIUrl":"https://doi.org/10.5455/medarh.2024.78.154-158","url":null,"abstract":"<p><strong>Background: </strong>Familial non-autoimmune hyperthyroidism is a rare disorder characterized by the absence of thyroid autoimmunity, particularly TSH receptor antibody [TRAb].</p><p><strong>Objective: </strong>The aim of this study was to describe a novel TSHR mutation identified in a family of two siblings and their father.</p><p><strong>Methods: </strong>Two siblings presented for endocrine assessment at ages 7 and 14 years with mild T3 toxicosis, and the father presented at 30 years of age with non-autoimmune thyrotoxicosis. Both siblings were treated with oral antithyroid therapy to achieve reasonable symptom control and thyroid function normalization. The father was treated with oral antithyroid therapy, radioactive iodine, thyroidectomy, and thyroid replacement therapy. Peripheral blood DNA was extracted from both affected siblings and father. Mutation analysis of TSHR was carried out by PCR and Sanger sequencing of both strands of the extracted DNA.</p><p><strong>Results: </strong>Both siblings and their father were heterozygous for the missense TSHR variant c.1855G>C, p.[Asp619His], in exon 10.</p><p><strong>Conclusions: </strong>This novel TSHR variant is associated with T3 toxicosis during childhood. Therefore, early identification and treatment may improve patient outcomes.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 2","pages":"154-158"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10983094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sporadic Malignant Triton Tumor of Shoulder: a Case Report.","authors":"Mohammad Al-Alwan, Ghaith Abu Noar, Ayat Al-Alwan, Sura Alrwabdeh, Mahmood Etawi","doi":"10.5455/medarh.2024.78.174-176","DOIUrl":"https://doi.org/10.5455/medarh.2024.78.174-176","url":null,"abstract":"<p><strong>Background: </strong>Malignant triton tumors (MTT) are subtype of malignant peripheral nerve sheath tumor (MPNST) which develop from Schwan cells of peripheral nerves or within neurofibromas, and shows rhabdomyoblastic differentiation. It is a rare soft tissue tumor with poor prognosis.</p><p><strong>Objective: </strong>We report a case of Malignant Triton Tumor (MTT) arising in the right shoulder in a 46 year old male patient presented to our Musculoskeletal Oncology Clinic at Royal Rehabilitation center at King Hussein Medical Center during June 2018.</p><p><strong>Case presentation: </strong>The patient was complaining of an 8 months long progressive right shoulder pain and swelling at the posterior lateral area of the shoulder. As accurate diagnosis is crucial in such case, investigations that included x-rays and magnetic resonance imaging (MRI) demonstrated an soft tissue tumor involving the right shoulder area leading to the differential diagnosis of aggressive soft tissue tumor which laid down the plan of an open incisional biopsy to be reported histopathological as a case of Malignant Triton Tumor which is a very rare and aggressive sarcoma originates from the peripheral nerve sheaths as it is subtype of malignant peripheral nerve sheath tumors after which excision of the entire tumor with safety margin was performed and referred for adjuvant chemotherapy.</p><p><strong>Conclusion: </strong>The treatment of choice is radical tumor excision with wide margins followed by chemotherapy and /or radiotherapy to improve the 5 years survival rates.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 2","pages":"174-176"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10983085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile Papillomatosis of the Breast: a Report of Two Cases with Review of the literature.","authors":"Mariam Al-Qurashi, Arwa Ibrahim, Tarek M ElSharkawy, Areej Al Nemer, Hiyam Alhaddad, Maha Abdel Hadi","doi":"10.5455/medarh.2024.78.170-173","DOIUrl":"https://doi.org/10.5455/medarh.2024.78.170-173","url":null,"abstract":"<p><strong>Background: </strong>Juvenile papillomatosis (JP) of the breast is a rare and benign proliferative disorder affecting young women. The affected patients tend to have an increased risk of breast cancer development during follow-up.</p><p><strong>Objective: </strong>This article aims to highlight a rare entity of breast disease, that harbor risk of breast cancer.</p><p><strong>Case presentation: </strong>Here, we present 2 cases of JP in young females; the first case is a 13 year-old presented with spontaneous nipple discharge, while the other patient is a 24 year-old presented with a right breast lump. Both patients had a total excision of the breast lesions, revealing JP at histology. Discussion: Juvenile Papillomatosis is considered a clinicopathological entity and is usually misdiagnosed as fibroadenoma clinically and radiologically, which requires histological correlation. The histologic findings are well-defined (hyperplasia, papillomatosis, and multiple cysts with foamy histiocytes).The controversy in management between surgery and observation is because of insufficient knowledge about the direct relationship between JP and subsequent cancer.</p><p><strong>Conclusion: </strong>Considering the risk of developing breast cancer in JP, enrolling patients and their families in a close follow-up and surveillance program is crucial.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 2","pages":"170-173"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10983086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chordoma of the Oropharynx.","authors":"Almedina Ramas, Merima Kasumovic, Sabrina Uscupsic, Majda Mujic, Lejla Tokic","doi":"10.5455/medarh.2024.78.68-70","DOIUrl":"10.5455/medarh.2024.78.68-70","url":null,"abstract":"<p><strong>Background: </strong>Chordoma is a rare malignant neoplasm that predominantly arises from the axial skeleton, but can also develop in unusual locations. However, there are also rare cases of \"NOS\" chordoma involving the oropharyx and epithelial-myoepithelial carcinoma of the parotid gland in the same patient. According to contemporary research, chordoma is a rare malignant neoplasm that arises from the embryonic remnants of the notochord. and typically involves the clivus, sacrococcygeal bones or vertebrae. Studies have shown that the incidence of chordoma has been estimated to be one per one million people per year. Chordoma can occur at any age, but most commonly it is diagnosed in the 40-60 year old age group with the male predominance.</p><p><strong>Objective: </strong>The aim of this article was to review the case of a 74-year-old female patient with epithelial-myoepithelial carcinoma of the parotid gland and a case of \"NOS\" chordoma involving the oropharyx.</p><p><strong>Methods: </strong>Diagnostic methods were used to examine a female patient with two primary malignant tumors: CT neck scan, CT of paranasal sinuses, ultrasound examination, scintigraphy and operative finding.</p><p><strong>Case presentzation: </strong>Due to the anatomy complexity, complete resection of the tumor through a transoral-transpharyngeal approach was not possible. Intraoperative palpation of the mass revealed well defined submucosal lesion 20x43x46mm beginning at the level of the oro- and hypopharynx and extending superiorly to the nasopharynx, and posteriorly into the spinal canal and intervertebral foramen causing near complete occlusion of the oro and hypopharynx. The patient also underwent extracapsular dissection of the parotid tumor. Postoperative palliative radiotherapy was performed.</p><p><strong>Conclusion: </strong>Surgical treatment remains the mainstay of treatment for EMC and radiation is imperative for patients who refuse surgery and for those with advanced or inoperable diseases.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 1","pages":"68-70"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical Challenges with the Informed Consent Process in Pediatric Research Studies.","authors":"Thabit S Alotaibi","doi":"10.5455/medarh.2024.78.65-67","DOIUrl":"10.5455/medarh.2024.78.65-67","url":null,"abstract":"<p><strong>Background: </strong>Informed Consent (IC) is crucial in pediatric research, aligning with the National Research Act of 1974 and the Belmont Report's principles. Current regulations, particularly 45 CFR 46, provide additional safeguards for children in research.</p><p><strong>Objective: </strong>This article explores ethical challenges in pediatric research IC, drawing from PubMed literature and regulatory guidelines to understand historical context, legislative milestones, and contemporary issues.</p><p><strong>Methods: </strong>A literature review, primarily sourced from PubMed, informed the examination of pediatric research and IC, referencing guidelines from the American Academy of Pediatrics and regulations from the FDA and HHS.</p><p><strong>Results: </strong>The study underscores the need for increased pediatric research due to the prevalence of drugs studied on adults. Despite legislative efforts like the FDAMA and Pediatric Research Equity Act, ethical challenges persist in obtaining IC in pediatric studies.</p><p><strong>Conclusion: </strong>Pediatric research necessitates nuanced IC approaches, involving parents, guardians, and children. Ethical challenges such as coercion and compensation require attention, with recommendations emphasizing guideline adherence and increased public engagement for trust-building and pediatric health advancement.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 1","pages":"65-67"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serotonin Levels in Newly-Infected HIV-Positive: A Preliminary Study.","authors":"Muh Yusuf Tahir, Andi Agus Mumang, Kusrini S Kadar, Risna Halim Mubin, Firdaus Hamid","doi":"10.5455/medarh.2024.78.55-59","DOIUrl":"10.5455/medarh.2024.78.55-59","url":null,"abstract":"<p><strong>Background: </strong>HIV is still a global health concern worldwide and in 2021, a total of 27,000 newly infected cases were detected in the Indonesian population, specifically among adults. However, there is no available data found about serotonin levels in newly infected cases of HIV.</p><p><strong>Objective: </strong>This study aimed to preliminary investigate serotonin levels in newly-infected HIV-positive cases in the Indonesian population.</p><p><strong>Methods: </strong>A quantitative cross-sectional analytic design was used with a total of 54 newly-infected HIV-positive participants who were enrolled using the purposive sampling technique. The questionnaire, blood sampling, and ELISA methods for measuring serotonin were applied. Furthermore, the serotonin distribution was compared based on participants' characteristics using the Mann-Whitney U test. The main effect of characteristics was also tested by the generalized linear model.</p><p><strong>Results: </strong>The mean serotonin level was low and did not differ based on participants' characteristics.</p><p><strong>Conclusion: </strong>Low serotonin level is characteristic of people newly infected with HIV in Indonesia. This might be a manifestation of the depression stage, a consequence of infection, or the involvement in provoking HIV infection progression.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 1","pages":"55-59"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-Based Cross-Sectional Assessment Survey On Herpes Zoster Vaccination Practices.","authors":"Nouf F Bin Rubaian, Nada Alghamdi, Nada Alquorain, Serene R Almuhaidib, Nouf A AlShamlan, Assim M AlAbdulKader, Moataza M Abdel Wahab, Malak A Al-Shammari","doi":"10.5455/medarh.2024.78.95-99","DOIUrl":"https://doi.org/10.5455/medarh.2024.78.95-99","url":null,"abstract":"<p><strong>Background: </strong>Herpes Zoster (HZ), also known as Shingles, is a commonly occurring infection especially among the elderly. It is due to the reactivation of the dormant virus in the sensory ends that were present since the primary infection with the virus.</p><p><strong>Objective: </strong>Our study aims at assessing the knowledge, attitudes practices beliefs and current barriers towards the Shingrix vaccine to fully understand where we stand and come up with proper recommendations to services these at-risk individuals and ultimately have a positive impact on the healthcare system.</p><p><strong>Methods: </strong>Questionnaire based cross sectional study using a translated version of a previously developed and tested questionnaire.</p><p><strong>Results: </strong>more than 8000 participants responded to the survey. The vast majority had chicken pox before and did hear about the vaccine from different sources. Most of the participants had minimal knowledge regarding the vaccine and were willing to take it regardless of some safety concerns.</p><p><strong>Conclusion: </strong>more efforts need to be conducted to enhance vaccine uptake in at risk populations in Saudi Arabia.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 2","pages":"95-99"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10983100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD56 Expression in Spleen Tissue Pathology and Its Implications in the Development of Type 1 Diabetes: Insights from Diabetic Rat Models.","authors":"Suha Khayri Ababneh, Osama Odat, Ali Ata Alsarhan, Jumanah D Al-Shawabkeh, Futoon Abedrabbu Al-Rawashde, Rawan Al-Jaloudi, Moath Alqaraleh, Nihad Al-Othman, Ahed J Alkhatib","doi":"10.5455/medarh.2024.78.274-278","DOIUrl":"10.5455/medarh.2024.78.274-278","url":null,"abstract":"<p><strong>Background: </strong>Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of beta cells in the pancreas.</p><p><strong>Objective: </strong>This study's goals were to look at how much CD56 was expressed in the spleen tissue of rats with type 1 diabetes and compare it to rats that were not diabetic.</p><p><strong>Methods: </strong>The method used in this study was to give rats type 1 diabetes by giving them Alloxan (120 mg/kg). The rats had diabetes for one month. As soon as the experiment was over, all the animals were put down and prepared for normal biochemical, histology, and immunohistochemical tests.</p><p><strong>Results: </strong>The study results revealed that the biochemical findings including glucose, cholesterol, and triglycerides in diabetic group were more significantly higher than that in the control group. The spleen tissue of diabetic rats was more inflamed than that of the control group, as shown by histological results. CD56 expression was much lower in the rats of diabetic group compared to the rats in the control group.</p><p><strong>Conclusion: </strong>When looked at as a whole, CD56's role in diabetes seems to have been lost. This explains why people with type 1 diabetes have inflammatory problems.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 4","pages":"274-278"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}