Medical archives (Sarajevo, Bosnia and Herzegovina)最新文献

{"title":"Umbilical Cord-Derived Mesenchymal Stem Cells Improve TGF-β, α-SMA and Collagen on Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats.","authors":"Ade Indra Mukti,&nbsp;Syafruddin Ilyas,&nbsp;Syah Mirsya Warli,&nbsp;Agung Putra,&nbsp;Nur Rasyid,&nbsp;Delfitri Munir,&nbsp;Kamal Basri Siregar,&nbsp;Muhammad Ichwan","doi":"10.5455/medarh.2022.76.4-11","DOIUrl":"https://doi.org/10.5455/medarh.2022.76.4-11","url":null,"abstract":"<p><strong>Background: </strong>A Erectile dysfunction (ED) is one of the well-known comorbidities in males with diabetes mellitus (DM), whose pathogenesis might be induced by dysregulation of corpus cavernosum smooth muscle cells. UC-MSCs are multipotent cells that attract considerable interest due to immunoregulatory properties and might be a potential strategy to regulate and recover the functional cells and tissues, including tissue improvement in DMED.</p><p><strong>Objective: </strong>This study aims to determine the efficacy of UC-MSCs in improving the erectile function of DMED rats through analyzing the expression of TGF-β, α-SMA, and collagen.</p><p><strong>Methods: </strong>Total number of 30 male Sprague-Dawley rats (6 to 8 weeks old) were randomly divided into four groups (negative control group, positive control group, T1 group, and T2 group). After 16 h fast, 24 rats were randomly selected and intraperitoneally injected with streptozotocin to induce DM. At 8 weeks after STZ injection, rats with DMED were identified by unresponsive erectile stimulation within 30 min. PC group received 500 μL; T1 rats treated with 500 μL PBS containing 1x106 UC-MSCs; T2 rats treated with 500 μL PBS containing 3x106 UC-MSCs. After MSCs treatment, the rats were sacrificed and the corpus cavernosum tissues were prepared for histological observations.</p><p><strong>Results: </strong>This study resulted in the administration of UC-MSCs could downregulate the expression of TGF-β, α-SMA, and collagen leading to the improvement of DMED.</p><p><strong>Conclusion: </strong>UC-MSCs improve the expression of TGF-β, α-SMA, and collagen on erectile dysfunction in streptozotocin-induced diabetic rats.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"76 1","pages":"4-11"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/1a/medarch-76-4.PMC8976889.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer Tomography (CT) Characteristics of Pulmonary Cystic Echinococcosis.","authors":"Aida Armoon,&nbsp;Payam Mehrian,&nbsp;Hussein Soleimantabar,&nbsp;Shabnam Torabi,&nbsp;Bahareh Heshmat Ghahderijani","doi":"10.5455/medarh.2019.73.338-343","DOIUrl":"https://doi.org/10.5455/medarh.2019.73.338-343","url":null,"abstract":"<p><strong>Introduction: </strong>Cystic echinococcosis (CE) is a common zoonosis worldwide. The two most frequent location of CE are liver and lung. Confirmatory diagnosis of CE is routinely performed sung imaging methods such as computer aided tomography and nuclear magnetic resonance in humans.</p><p><strong>Aim: </strong>to investigate CT scan imaging of patients with pulmonary CE in Masih Daneshvari Hospital from 2011 to 2017.</p><p><strong>Matarial and methods: </strong>This descriptive-analytic study was carried out on patients with pulmonary CE referring to Masih Daneshvari Hospital. By using the convenience sampling, 195 cases were selected from eligible patients. The data collection tool was a researcher-made questionnaire that included demographic, clinical and laboratory information. Data were analyzed using SPSS software version 20.</p><p><strong>Results: </strong>In this study, 84.1% and 15.9% of patients were diagnosed using surgical method and CT scan, respectively. Our findings indicated CE was most commonly located in liver (28.2%) and spleen was considered as the lowest location (3.1%). Furthermore, cough was the most common clinical symptom of patients. The lower right lobe opacity was found to be higher, while and Lingula was the least frequent.</p><p><strong>Conclusion: </strong>According to the findings of this study, surgery is the most important diagnostic and cough method as the most common clinical symptom of the disease. Since the CE with atypical symptoms is relatively common, physicians should always consider the lung CE in differential diagnosis of localized radiological images.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"73 5","pages":"338-343"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/3b/medarch-73-338.PMC6885213.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Most Influential Physicians in Bosnia and Herzegovina: Stanko Sielski (1891-1958).","authors":"Izet Masic","doi":"10.5455/medarh.2019.73.362-365","DOIUrl":"10.5455/medarh.2019.73.362-365","url":null,"abstract":"","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"73 5","pages":"362-365"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/03/17/medarch-73-362.PMC6885214.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of Cytogenetic Findings and its Effect on the Outcome of Pediatric Acute Lymphoblastic Leukemia.","authors":"Gholamreza Bahoush, Marzieh Nojoomi","doi":"10.5455/medarh.2019.73.311-315","DOIUrl":"10.5455/medarh.2019.73.311-315","url":null,"abstract":"<p><strong>Introduction: </strong>Acute lymphoblastic leukemia (ALL) is one of the most common cancers in children and accounts for about ⅓ of cancers in children. The annual incidence of ALL is 4 patients per 100,000 children. Their peak age is between 2-5 Year. One of the most important prognostic factors is cytogenetic abnormalities which are very effective in determining treatment policy.</p><p><strong>Aim: </strong>To determine the frequency of cytogenetic findings and its effect on the outcome of children with ALL.</p><p><strong>Materials and methods: </strong>This retrospective cross-sectional analytical study was conducted on children with ALL who their disease was diagnosed between 2001and 2009. Furthermore, 206 patients with ALL were examined by referring to Clinic of Ali Asghar Hospital in Tehran. Data was collected from medical records and analyzed by SPSS16 software.</p><p><strong>Results: </strong>206 children with ALL were enrolled in the study. The estimated event-free survival rate of all enrolled patients was more than 70%. There was a significant relationship between type of cytogenetic disorder and clinical outcome of patients (P˂0.0001), where the highest mortality was observed in patients with t (9;22) and t (4;11). There was no significant correlation between the sex and age with the clinical outcome of the patient (P = 0.064; p=0.322). There was a statistically significant relationship between mediastinal mass and clinical outcome (P = 0.002), indicating that the presence of cells growth in an involuntary way can be cause of the cancer. A significant association was found between the clinical outcome of patients and radiotherapy (P = 0.043), indicating that radiotherapy is effective in improving cancer.</p><p><strong>Conclusion: </strong>The findings demonstrated that the average survival rate without recurrence in children was at level of the European countries. However, the strong chemotherapy weakened the role of many prognostic factors in ALL patients, but some translocations are prognostic factors in predicting death in patients with ALL. Therefore, patients with this factor need to receive more confident treatment policy. Comprehensive studies are required by focusing on more samples because of low number of relapses and deaths in the present study.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"73 5","pages":"311-315"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/89/medarch-73-311.PMC6885216.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatibility of Portunus Pelagicus Hydroxyapatite Graft on Human Gingival Fibroblast Cell Culture.","authors":"Michael Josef Kridanto Kamadjaja,&nbsp;Janery Fidelia Abraham,&nbsp;Harry Laksono","doi":"10.5455/medarh.2019.73.303-306","DOIUrl":"https://doi.org/10.5455/medarh.2019.73.303-306","url":null,"abstract":"<p><strong>Introduction: </strong>Crab shell (<i>Portunus pelagicus</i>) has the potential to be a source of hydroxyapatite biomaterials that used as bone grafts. Before clinical application, crab shell graft should be tested for its biocompatibility in vitro on human gingival fibroblast.</p><p><strong>Aim: </strong>This study aimed to determine the biocompatibility of <i>Portunus pelagicus</i> hydroxyapatite graft on human gingival fibroblast cell culture.</p><p><strong>Material and methods: </strong>Human gingival fibroblast cell cultures were divided into control group and treatment group with the addition of hydroxyapatite graft powder from <i>Portunus pelagicus</i> at a concentration of 100 ppm, 50 ppm, and 25 ppm. The synthesis process of hydroxyapatite was conducted by heating at 1000°C then characterizing the compound with SEM-EDX. All samples were incubated in α-MEM medium, then were given MTT material. The cultures on the plate were examined using ELISA reader. The results were analyzed using a Oneway Anova.</p><p><strong>Results: </strong>The percentage of living cells throughout all treatment group shown results that exceeded the LD50 parameter. The highest percentage of living cells was at 25 ppm concentration group.</p><p><strong>Conclusion: </strong>The hydroxyapatite graft powder from crab shells is biocompatible with human gingival fibroblast cell culture.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"73 5","pages":"303-306"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/3f/medarch-73-303.PMC6885209.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacists' Attitudes and Role in Diabetes Management in Bosnia and Herzegovina.","authors":"Tarik Catic,&nbsp;Rasim Jusufovic,&nbsp;Dzan Horozic,&nbsp;Lana Lekic,&nbsp;Vedad Tabakovic","doi":"10.5455/medarh.2019.73.351-355","DOIUrl":"https://doi.org/10.5455/medarh.2019.73.351-355","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes is the fastest growing chronic diseases worldwide and in Bosnia and Herzegovina. International standards for diabetes care have recognized the crucial role of pharmacists in diabetes management. Community pharmacists can provide services beyond medication dispensing inducing patient identification, assessment, education, referral, monitoring and behavioral counseling. Pharmacists' attitudes toward diabetes are generally positive but do not correlate with the degree of their involvement in diabetes management and frequency of providing diabetes-related services varied throughout countries.</p><p><strong>Aim: </strong>To measure pharmacists' attitude toward diabetes management and to identify pharmacy services that are currently provided to patients with diabetes.</p><p><strong>Material and methods: </strong>We have conducted a descriptive, cross-sectional survey-based study among pharmacists from Bosnia and Herzegovina attending on of the conferences in May 2018. Majority of pharmacist attending such conferences are from community pharmacies across the whole country considering surveyed sample was representative. The questionnaire contained 3 different sections: a) participants' demographics, b) measured participants' attitude toward diabetes using the DAS-3 to measure participants' degree of agreement to 33 diabetes-related statements, on a 5-point Likert type scale and c) a list of possible diabetes patient support activities that could be delivered by pharmacists based on authors experience and available literature.</p><p><strong>Results: </strong>The majority of respondents (86,5%) were female and 53,8% work in private owned pharmacies. Interest in diabetes was indicated by 94,2% while 59,6% completed special diabetes continuing education in the past. All the respondents expressed positive attitudes in all DAS-3 with no significant difference between overall DAS-3 and subscale values. Provided services differ but mainly drug oriented and partially include comorbidity counseling.</p><p><strong>Conclusion: </strong>Pharmacists had positive attitudes toward diabetes but they provided limited diabetes-related services to patients. Additional special education is needed.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"73 5","pages":"351-355"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ce/92/medarch-73-351.PMC6885234.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Serum Ykl-40 and Ischemia Modified Albulmin Levels Between Pregnant Women with Hyperemesis Gravidarum and Normal Pregnant Women.","authors":"Murat Bulanık,&nbsp;Nevin Sağsöz,&nbsp;Cemile Dayangan Sayan,&nbsp;Mahmut İlkin Yeral,&nbsp;Üçler Kısa","doi":"10.5455/medarh.2019.73.97-100","DOIUrl":"https://doi.org/10.5455/medarh.2019.73.97-100","url":null,"abstract":"<p><strong>Introduction: </strong>The etiopathogenesis of HG is still unclear.</p><p><strong>Aim: </strong>The aim of this study was to investigate the levels of YKL-40 protein as an inflammatory marker and evaluate the levels of IMA as an oxidative marker in hyperemesis gravidarum women.</p><p><strong>Materials and methods: </strong>Totally 35 patients with hyperemesis gravidarum and 35 healthy pregnants were included in the study. Singleton pregnancies between 6+0 week and 13+6 weeks of gestation, with normal fetal anatomy were included in the study. Complete blood count, complete urine analyze, biochemical tests and thyroid function tests were done.</p><p><strong>Results: </strong>There was no significant difference between groups for demographical features (age, gravidity, gestational age, body mass index). Also, there was no statistically significant difference between groups for IMA levels (p>0.05). The median level of YKL-40 was higher in pregnants with hyperemesis gravidarum than normal pregnants but the difference was not statistically significance (p>0.05).</p><p><strong>Conclusion: </strong>Further comprehensive studies with more number of patients are needed to show the efficacy of YKL-40 and IMA levels for predicting hyperemesis gravidarum and even monitoring of the treatment.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"73 2","pages":"97-100"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5455/medarh.2019.73.97-100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71435104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Level of Polymorphonuclear Neutrophil Leukocytes and Bronchial Hyperreactivity in Chronic Obstructive Pulmonary Disease.","authors":"Vesna Cukic","doi":"10.5455/medarh.2015.69.244-246","DOIUrl":"https://doi.org/10.5455/medarh.2015.69.244-246","url":null,"abstract":"<p><strong>Introduction: </strong>Polymorphonuclear neutrophil leukocytes (PMNL) have an important defensive role against various microorganisms and other agents, but by liberating various substances, first of all the superoxide anion (O 2¯), they can damage the bronchial mucosa and influence the development of bronchial inflammation which is the fundamental of bronchial hyperreactivity (BHR).</p><p><strong>Objective: </strong>to show the role of the PMNL for development and level of BHR in patients with chronic obstructive pulmonary disease (COPD).</p><p><strong>Material and methods: </strong>We observed 160 patients with COPD treated in Clinic for Pulmonary Diseases and TB \"Podhrastovi\" Sarajevo during three years :from 2012 to 2014. They were divided into groups and subgroups according to the first registration of BHR in the course of illness and to the number of exacerbations of the disease in one year. The number of blood PMNL was measured in a stable state of disease at the begging and at the end of investigation.</p><p><strong>Results: </strong>The number of blood PMNL was significantly greater in patients with 3 or more exacerbations per one year (p <0.01). Patients with BHR had significantly greater number blood PMNL than patients without BHR (p< 0.05). Patients with 3 exacerbations per year had a statistically significant increase of number of PMNL between first and last examination (p<0.01).</p><p><strong>Conclusion: </strong>There is statistically significant correlation between the number of blood PMNL and the level of BHR in COPD, but future examination need to be done to determine real role and mode of action of PMNL for these processes.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"69 4","pages":"244-6"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71434977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the physical activity on the cognitive functions with people depending on their age.","authors":"J. P. Gligoroska, S. Mancevska, B. Dejanova, S. Petrovska, L. Todorovska, V. Petrova, V. Antovska, L. Božinovska","doi":"10.5455/MEDARH.2012.66.271-275","DOIUrl":"https://doi.org/10.5455/MEDARH.2012.66.271-275","url":null,"abstract":"In comparison with the number of studies which have examined the physical activity influence on the cognitive capabilities with the adults (above 60 years of age), researches for children, adolescents and young adult population are rarely done. The examination of the potential connection, role or influence between Physi-cal Activity and cognition during early age (the first third of the human life) is very complex and subtle due to a large number of external factors which are present in the period during which the cognitive capabilities are still being developed. Regular physical activity improves the physiological and psychological aspect of human health. Due to the well known advantages and benefits from the physical activity, one would expect it to be more present in the life of contemporary man. But it is a fact that the level of physical activity with people decreases in the course of life-time, especially in the period when young people move from secondary school to university. The decrease of the physical activity additionally increases the pressure over the young academic persons. There is not enough literature which examines the connection of the neuropsychological indicators and physical activity with young adults. It is obvious the need for further researches in this field which will create a solid base for the connection of the physical activity and cognition, the same one that is found for the adult population. Within the frame of positive role the physical activity has over the cognitive health, it is suggested as a means of reducing the risk of developing cognitive decrease connected with getting old. Future vast random-ized researches and interventions would have to test the quantity and the type of physical activity which would be recommended in order to prevent or postpone the cognitive decrease.","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"31 1 1","pages":"271-275"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78899159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}