Medical archives (Sarajevo, Bosnia and Herzegovina)最新文献

{"title":"Synergistic Impact of Nasal Irrigation and Health Education in Reducing Chronic Rhinosinusitis Among Cement Plant Workers: a Randomized Controlled Trial.","authors":"Nguyen Quang Hung, Vo Hoang Long, Nguyen Quang Truong","doi":"10.5455/medarh.2025.79.184-189","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.184-189","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinosinusitis (CRS) is a prevalent and debilitating condition among industrial workers exposed to occupational hazards such as dust and chemical irritants. Despite its significant impact on quality of life and productivity, evidence-based interventions for occupational CRS remain limited.</p><p><strong>Objective: </strong>This study evaluates the effectiveness of combined health education and nasal irrigation in reducing CRS symptoms among direct labor workers at the Hai Phong Cement Plant, Vietnam.</p><p><strong>Methods: </strong>A randomized controlled trial was conducted from 2014 to 2015, involving 90 workers diagnosed with CRS. Participants were randomly assigned to an intervention group (n=45), receiving nasal irrigation kits and training, or a control group (n=45), receiving health education only. Health education sessions focused on improving knowledge, attitudes, and practices (KAP) related to CRS prevention. Nasal irrigation involved twice-daily rinsing with 0.9% saline solution. Outcomes were assessed using structured questionnaires, clinical examinations, and the Intervention Effectiveness Index (HQCT).</p><p><strong>Results: </strong>The health education intervention significantly improved KAP scores, with a 2967% increase in positive attitudes and an 847% improvement in understanding preventive measures. Nasal irrigation demonstrated substantial efficacy, reducing moderate nasal discharge by 58% and nasal congestion by 1600%. Objective findings revealed a 1657% increase in workers reporting no nasal cavity discharge and a 158% improvement in nasal mucosal health. After six months, 60% of the nasal irrigation group reported \"good\" improvement, compared to 11.1% in the control group (p < 0.05).</p><p><strong>Conclusions: </strong>This study highlights the synergistic potential of health education and nasal irrigation in managing occupational CRS. Nasal irrigation, in particular, emerged as a highly effective, low-cost intervention for alleviating CRS symptoms in high-risk industrial settings. These findings underscore the importance of integrating non-pharmacological approaches into occupational health programs to safeguard respiratory health among workers exposed to environmental hazards.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 3","pages":"184-189"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Ultrasound Assessment of Abdominal Aortic Diameter and Prevalence of Infrarenal Aortic Aneurysm in Individuals Aged 60 Years and Above.","authors":"Nguyen Tuan Hai, Pham Manh Hung, Nguyen Ngoc Quang","doi":"10.5455/medarh.2025.79.181-183","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.181-183","url":null,"abstract":"<p><strong>Background: </strong>Vascular ultrasound evaluation of the abdominal aorta is a simple and efficient technique for assessing the morphology and size of the abdominal aorta, as well as for identifying infrarenal aortic aneurysms, a potential condition with significant mortality.</p><p><strong>Objective: </strong>This study aims to evaluate the diameter and morphology of abdominal aorta in a community-based population using vascular ultrasound and to determine the prevalence of infrarenal aortic aneurysms.</p><p><strong>Methods: </strong>A randomized sample of individuals aged 60 years and above was recruited from several provinces. Abdominal aortic diameters were measured using vascular ultrasound according to established international guidelines.</p><p><strong>Results: </strong>810 individuals were enrolled in the study, of whom 40.2% were male, with a mean age of 70.9 ± 7.56 years. The mean infrarenal abdominal aortic diameter was 18.2 ± 2.93 mm in men and 16.3 ± 1.87 mm in women (p < 0.001). A significant increase in aortic diameter was observed with advancing age. Age, male sex, body surface area, and current smoking status were significant predictors of infrarenal aortic diameter.</p><p><strong>Conclusion: </strong>In this population-based survey, the mean infrarenal abdominal aortic diameter was 18.2 ± 2.93 mm in men and 16.3 ± 1.87 mm in women, with an infrarenal aortic aneurysm prevalence of 0.12%. Further population-based studies with a bigger sample and extended follow-up are necessary to investigate further the aortic morphologies predisposing to later aneurysm.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 3","pages":"181-183"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Covid-19 With the Occurrence of a Depressive Disorder.","authors":"Danijel Bijedic, Elvir Becirovic, Jasminka Petrovic, Humera Porobic Jahic, Alma Trnacevic, Azra Zigic","doi":"10.5455/medarh.2025.79.211-214","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.211-214","url":null,"abstract":"<p><strong>Background: </strong>Depressive disorder is characterized by a persistent low mood (sadness, irritability, or emptiness) or a loss of pleasure, accompanied by other cognitive, behavioral, or neurovegetative symptoms that significantly impair a person's ability to function. Anxiety and fear-related disorders are marked by excessive anxiety and fear, which lead to behavioral disturbances and cause significant distress or impair personal, family, social, educational, occupational, or other key areas of functioning.</p><p><strong>Objective: </strong>The aim of this study was to analyze whether there are differences in the development of depressive symptoms between COVID-19 patients and patients with symptoms of the flu or common cold.</p><p><strong>Methods: </strong>This is a prospective study that included sixty participants: thirty with COVID-19 and thirty without COVID-19. Data were collected from the ambulatory observational records of participants, documenting their symptoms. We analyzed the relationship between variables such as age, sex, education, and the level of potential depression. The participants were divided into two groups: one consisting of individuals with COVID-19 and the other of individuals without COVID-19. All participants were male and female, aged between 40 and 65 years, and had no previous history of depressive disorder. The first group consisted of patients with COVID-19 who were treated at home but were examined at our outpatient clinic and subsequently sent home.</p><p><strong>Results: </strong>Statistical data processing was performed using the Excel program and the R statistical data processing program. Percentages are calculated in relation to 30 respondents in each group.There was no statistically significant correlation between the level of education in Group 1 and the development of depression(Spearman ro=0.007, P=0.972). In Group 1 (Covid ) there is a statistically significant correlation between the age of the subjects and the development of depression (Spearman ro=0.44, P=0.015). A positive value of the Spearman correlation coefficient means that the score increases with the age of the respondent. Three questions with the highest score in group 1 were: Question 2=71, Questions 15 and 16=66, Question 14=65; three questions with the highest score in group 2 were: Question 2=74, Question 1 =50, Question 18=46.</p><p><strong>Conclusion: </strong>COVID-19 can contribute to the development of depression. In our study, 16.7% of patients with COVID-19 showed signs of depression, with 10% experiencing mild depression and 6.7% experiencing moderate depression. Patients in the first group, particularly those of older age, were more likely to develop mild or moderate depression associated with COVID-19. Additionally, no statistically significant correlation was found between the level of education in Group 1 and the development of depression.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 3","pages":"211-214"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fully Digital Workflow for Immediate Prosthetic Implant on Microsurgery Fibula Flap for Mandibular Reconstruction.","authors":"Truong Dinh Van, Long Nguyen Khanh, Hieu Nguyen Dinh, My Hoang Phong, Chinh Cao Duc","doi":"10.5455/medarh.2025.79.215-219","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.215-219","url":null,"abstract":"<p><strong>Background: </strong>Immediate implant-retained surgery on the fibula using the traditional method is a technical challenge in mandibular reconstruction and can worsen the following prosthetic process. A digital workflow with multiple surgical guidance tools can help ensure accuracy and even immediate temporary prosthesis placement in mandibular reconstruction using fibula flaps.</p><p><strong>Objective: </strong>In this article, we present a digital workflow for dental implant placement in the fibula flap using a 3D-printed surgical guide before the vascularization of the flap and temporary prosthesis immediately during surgery.</p><p><strong>Case presentation: </strong>This procedure includes resection of the mandibular lesion, immediate reconstruction with a fibula flap, immediate implant placement, and provisional prosthesis placement. Our patient received both mandibular reconstruction and dental implant prosthesis completed in a single day at the tumor resection stage, which enormously shortens the recovery time without teeth to zero. Regarding the implant position on the fibula, the results were awe-inspiring. We measured and compared with the assumed plan; the neck deviation was about 1.47mm, the average change in implant height was 1.06mm, and the average implant deviation angle was 9.17 degrees. The above results helped the process of trying on temporary restorations and grinding the occlusion completely smoothly, even with the permanent restoration process later.</p><p><strong>Conclusion: </strong>We report two cases utilizing the fully digital \"Jaw in a Day\" workflow. VSP and surgical guidance are essential in the precise cutting and shaping of the fibula flap and the prosthetic restoration with dental implants.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 3","pages":"215-219"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Preoperative Enteral Nutrition on Clinical Outcomes in Malnourished Patients Undergoing Elective Colorectal Cancer Surgery: A Prospective Cohort Study.","authors":"Fuad Pasic, Haris Elezovic","doi":"10.5455/medarh.2025.79.227-232","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.227-232","url":null,"abstract":"<p><strong>Background: </strong>Malnutrition is a frequent yet often overlooked comorbidity in patients undergoing surgery for colorectal cancer. It is associated with adverse postoperative outcomes, including increased complications, prolonged hospital stay, and elevated mortality.</p><p><strong>Objective: </strong>This study aimed to assess the clinical impact of short-term preoperative enteral nutrition in malnourished patients undergoing elective colorectal cancer surgery.</p><p><strong>Methods: </strong>A prospective cohort study was conducted involving 68 malnourished patients with histologically confirmed stage I-III colorectal cancer. Patients were divided into three groups: Group A (14-day enteral nutrition), Group B (7-day enteral nutrition), and Group C (no supplementation). Nutritional status, laboratory parameters, postoperative complications, transfusion needs, and hospitalization metrics were compared among groups.</p><p><strong>Results: </strong>Group A demonstrated the most favorable outcomes, including significantly fewer postoperative complications such as anastomotic leakage (5.0% vs. 17.9%, p = 0.030), reduced transfusion and albumin requirements, and shorter ICU and hospital stays (1.6 ± 0.7 and 7.1 ± 2.4 days, respectively). Group C showed the highest complication and mortality rates. Improvements in biochemical markers were observed in both intervention groups, supporting the efficacy of enteral supplementation.</p><p><strong>Conclusion: </strong>Short-term preoperative enteral nutrition significantly improves clinical outcomes in malnourished colorectal cancer patients undergoing elective surgery. These findings support the integration of nutritional screening and intervention as standard components of perioperative care in oncologic surgery.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 3","pages":"227-232"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Perioperative Neonatal and Maternal Glycemic Response and APGAR Score During Elective Cesarean Section: Factors and Anesthetic Management.","authors":"Diab A Bani Hani, Omar F Altal, Ala A A Alhowary, Anas Alrusan, Rania Al-Bataieneh, Khayria Tahir, Shahed Shloul, Malak Issa, Ahmed Al Sharie","doi":"10.5455/medarh.2025.79.34-40","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.34-40","url":null,"abstract":"<p><strong>Background: </strong>The type of anesthesia and intensity of pain experienced during surgery are linked to the body's stress response, as reflected in preoperative and postoperative glucose levels.</p><p><strong>Objective: </strong>This comparative study aims to assess the hyperglycemic stress response to cesarean sections performed under different types of anesthesia.</p><p><strong>Methods: </strong>This prospective study included 302 participants, divided into two groups: a general anesthesia group and a spinal anesthesia group. Our primary objective was to investigate the effects of general versus spinal anesthesia on pregnant women undergoing cesarean section. Secondarily, we aimed to assess the impact of other factors on the maternal and neonatal stress response during surgery.</p><p><strong>Results: </strong>Both groups exhibited a significant proportional increase in mean blood glucose levels after surgery. However, this increase was more pronounced in the general anesthesia group than in the spinal anesthesia group. Therefore, spinal anesthesia had a greater effect in attenuating the hyperglycemic response to surgery during cesarean section compared to general anesthesia. Maternal blood glucose levels were significantly associated with steroid injection, type of anesthesia, and gestational age. In contrast, neonatal blood glucose was significantly associated with gestational age, APGAR score, maternal steroid injection, type of anesthesia, maternal age, and both preoperative and postoperative maternal blood glucose levels.</p><p><strong>Conclusion: </strong>Spinal anesthesia was superior to general anesthesia in attenuating both maternal and neonatal hyperglycemic responses during the cesarean section. This highlights the significant impact of anesthesia type on maternal and neonatal well-being.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 1","pages":"34-40"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Abnormal Morphokinetic Embryos, Genetic Testing Results, and Clinical Outcomes.","authors":"Diem Thi Yen, Nguyen Khang Son, Nguyen Thi Hue Giang, Le Thi Quyen, Doan Nhu Tho, Tran Thi Dieu Thuy, Nguyen Xuan Hoi","doi":"10.5455/medarh.2025.79.4-8","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.4-8","url":null,"abstract":"<p><strong>Background: </strong>Embryo quality is a crucial factor in the success of in vitro fertilization (IVF). Morphokinetics, which refers to the timing and sequence of embryonic cell division and development, has gained attention as a potential indicator of embryo viability and genetic competence.</p><p><strong>Objective: </strong>This study evaluates the relationship between abnormal embryonic morphokinetics and genetic analysis results, and their impact on clinical outcomes in assisted reproductive technology (ART).</p><p><strong>Methods: </strong>Conducted at Duc Phuc Hospital with Hanoi Medical University from January to December 2023, the prospective study included 152 patients undergoing in-vitro fertilization (IVF). A total of 968 blastocysts were analyzed using preimplantation genetic testing for aneuploidy (PGT-A). Time-lapse monitoring assessed cell division milestones and abnormal morphokinetic patterns, including direct cleavage, reverse cleavage, multinucleation, and vacuole. Patients received a single euploid embryo transfer. Clinical outcomes were tracked to the live birth stage, analyzed using SPSS 20.0, with p-values < 0.05 considered significant.</p><p><strong>Results: </strong>Of 583 blastocysts, 294 (50.4%) showed abnormal cleavage patterns. The aneuploidy rate was higher in embryos with reverse cleavage (56.1%) and multinucleation (50%), while direct cleavage and vacuolization showed no significant correlation. Early blastocyst formation (≥100 hours) was linked to a higher aneuploidy rate (60.8%). Nonetheless, clinical outcomes, such as β-hCG positivity and live birth rates, were similar between abnormal and normal cleavage groups when euploid embryos were transferred.</p><p><strong>Conclusion: </strong>Abnormal morphokinetic patterns are linked to higher aneuploidy rates, but do not significantly affect clinical outcomes when euploid embryos are selected. Integrating genetic testing with morphokinetic assessment can optimize ART success rates.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 1","pages":"4-8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Otolaryngological Manifestations and Associated Biochemical, Hematological, and Immunological Profiles in HIV-Positive Patients in Vietnam.","authors":"Truong Quang Nguyen, Nguyen Quang Hung","doi":"10.5455/medarh.2025.79.220-226","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.220-226","url":null,"abstract":"<p><strong>Background: </strong>The global HIV/AIDS epidemic, with its significant presence in Vietnam by the early 2000s, often linked to injecting drug use, prompted concern at the National Otorhinolaryngology Hospital due to a rising prevalence of HIV among ENT patients. This highlighted a need to understand their specific clinical and laboratory profiles.</p><p><strong>Objective: </strong>This study aimed to systematically evaluate selected biochemical, hematological, and immunological parameters in these HIV-positive ENT patients to characterize their infection and identify significant laboratory alterations.</p><p><strong>Methods: </strong>This retrospective-prospective cohort study included 104 HIV-positive ENT patients from January 2010 to August 2014. HIV diagnoses were confirmed via a multi-test approach. Demographic, risk behavior, and ENT diagnosis data were collected from medical records. Biochemical, hematological, and immunological (CD4, CD8, CD4/CD8 ratio) parameters were analyzed.</p><p><strong>Results: </strong>The cohort was predominantly young adult males (85.55%), with injecting drug use as the main risk factor (79.04%). Over half (53.60%) had HIV-related ENT conditions; 46.40% were incidentally diagnosed. Biochemical analysis showed significantly elevated total protein/globulin and reduced albumin/A/G ratio (p < 0.05). Hematologically, leukopenia (7.4% males) and mild/moderate anemia (20.4% males, 33.3% females) were observed. Immunological profiling revealed significantly decreased CD4 counts (264±89.57 cells/mm³) and CD4/CD8 ratios, alongside increased CD8 counts (all p < 0.05).</p><p><strong>Conclusion: </strong>HIV-positive ENT patients in Vietnam exhibit typical demographic/risk profiles and frequent HIV-related ENT manifestations. Significant biochemical, hematological, and profound immunological abnormalities underscore HIV's systemic impact. ENT clinics are crucial for early HIV detection, necessitating comprehensive laboratory monitoring for effective disease management.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 3","pages":"220-226"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation Between Plasma Bilirubin Concentrations and Glomerular Filtration Rate and Creatinine in Type 2 Diabetes with Renal Damage.","authors":"Nguyen Tien Dung, Hoang Thi Ngoc Tram, Vu Thi Thu Hang, Pham Thi Thuy","doi":"10.5455/medarh.2025.79.52-55","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.52-55","url":null,"abstract":"<p><strong>Background: </strong>Diabetic nephropathy is one of the causes of chronic kidney disease with a very complex mechanism, in which oxidative stress plays an important role and bilirubin acts as an effective antioxidant, protecting cells from damage caused by oxidative stress.</p><p><strong>Objective: </strong>The aim of the study was to investigate the relationship between plasma bilirubin concentration with glomerular filtration rate and creatinine in patients with type 2 diabetes with renal damage.</p><p><strong>Methods: </strong>Total amount of 60 patients with type 2 diabetes with renal damage. Study design was descriptive.</p><p><strong>Results: </strong>Mean age 64.1±4.76. The rate of decreased glomerular filtration rate was 86.7% and increased albuminuria accounted for 96.7%. The concentration of total bilirubin in plasma decreased correspondingly to the decrease in glomerular filtration rate. The concentration of total, free and conjugated bilirubin was negatively correlated with creatinine concentration (r=-0.48), (r=-0.37), (r=-0.34) and positively correlated with glomerular filtration rate (r=0.54), (r=0.45), (r=0.41) with p<0.05). The area under the curve (AUC) of total bilirubin concentration was 0.7, lower than the area under the curve (AUC) of creatinine concentration 0.8, uric acid 0.74.</p><p><strong>Conclusion: </strong>Plasma bilirubin concentration is inversely correlated with creatinine concentration and positively correlated with glomerular filtration rate.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 1","pages":"52-55"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Analysis of Mediastinal Masses: a Single-Institute Experience.","authors":"Zeead M Alghamdi, Sharifah A Othman, Dhuha N Boumarah, Mohammed Sabry Abdelmotaleb, Farouk Alrashaid, Yasser Aljehani, Hatem Y Elbawab","doi":"10.5455/medarh.2025.79.15-19","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.15-19","url":null,"abstract":"<p><strong>Background: </strong>The centrally located portion of the thoracic cavity is called the mediastinum and consists of several essential organs. In the presence of various outcomes and prognostic indicators of mediastinal masses, meticulous diagnosis of these masses is considered crucial.</p><p><strong>Objective: </strong>In this study, we analyzed all mediastinal masses observed clinically and pathologically at one institution over a period of ten years.</p><p><strong>Methods: </strong>This is a retrospective, single-institution review of 94 patients with mediastinal masses, drawing on existing data recorded by the hospital. The study was carried out at the King Fahd University Hospital, Khobar, Saudi Arabia. Data was collected from 2009 to 2019. Participants were all patients with malignant or benign mediastinal masses admitted to the hospital, or diagnosed incidentally to have mediastinal masses during investigations for other reasons.</p><p><strong>Results: </strong>The mean age for developing a mediastinal mass was 33.89 ± 18.91 years of age. Most of the patients (69.1%) were symptomatic at presentation. Overall, (49.23%) of patients who were symptomatic at diagnosis had a malignant mass. Concerning pathologic diagnosis and presentation of the patient (symptomatic versus asymptomatic), there was a significant positive relationship between pathologic diagnosis and symptoms with a P value of 0.020. In our study, only 5.15% of cases experienced recurrence.</p><p><strong>Conclusion: </strong>This study provides a great understanding of mediastinal tumor biology and the role of both radiotherapy and chemotherapy in increasing the survival rates of patients suffering from similar malignant conditions.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 1","pages":"15-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}