Medical archives (Sarajevo, Bosnia and Herzegovina)最新文献

{"title":"Vascular Ultrasound Assessment of Abdominal Aortic Diameter and Prevalence of Infrarenal Aortic Aneurysm in Individuals Aged 60 Years and Above.","authors":"Nguyen Tuan Hai, Pham Manh Hung, Nguyen Ngoc Quang","doi":"10.5455/medarh.2025.79.181-183","DOIUrl":"10.5455/medarh.2025.79.181-183","url":null,"abstract":"<p><strong>Background: </strong>Vascular ultrasound evaluation of the abdominal aorta is a simple and efficient technique for assessing the morphology and size of the abdominal aorta, as well as for identifying infrarenal aortic aneurysms, a potential condition with significant mortality.</p><p><strong>Objective: </strong>This study aims to evaluate the diameter and morphology of abdominal aorta in a community-based population using vascular ultrasound and to determine the prevalence of infrarenal aortic aneurysms.</p><p><strong>Methods: </strong>A randomized sample of individuals aged 60 years and above was recruited from several provinces. Abdominal aortic diameters were measured using vascular ultrasound according to established international guidelines.</p><p><strong>Results: </strong>810 individuals were enrolled in the study, of whom 40.2% were male, with a mean age of 70.9 ± 7.56 years. The mean infrarenal abdominal aortic diameter was 18.2 ± 2.93 mm in men and 16.3 ± 1.87 mm in women (p < 0.001). A significant increase in aortic diameter was observed with advancing age. Age, male sex, body surface area, and current smoking status were significant predictors of infrarenal aortic diameter.</p><p><strong>Conclusion: </strong>In this population-based survey, the mean infrarenal abdominal aortic diameter was 18.2 ± 2.93 mm in men and 16.3 ± 1.87 mm in women, with an infrarenal aortic aneurysm prevalence of 0.12%. Further population-based studies with a bigger sample and extended follow-up are necessary to investigate further the aortic morphologies predisposing to later aneurysm.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 3","pages":"181-183"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Preoperative Enteral Nutrition on Clinical Outcomes in Malnourished Patients Undergoing Elective Colorectal Cancer Surgery: A Prospective Cohort Study.","authors":"Fuad Pasic, Haris Elezovic","doi":"10.5455/medarh.2025.79.227-232","DOIUrl":"10.5455/medarh.2025.79.227-232","url":null,"abstract":"<p><strong>Background: </strong>Malnutrition is a frequent yet often overlooked comorbidity in patients undergoing surgery for colorectal cancer. It is associated with adverse postoperative outcomes, including increased complications, prolonged hospital stay, and elevated mortality.</p><p><strong>Objective: </strong>This study aimed to assess the clinical impact of short-term preoperative enteral nutrition in malnourished patients undergoing elective colorectal cancer surgery.</p><p><strong>Methods: </strong>A prospective cohort study was conducted involving 68 malnourished patients with histologically confirmed stage I-III colorectal cancer. Patients were divided into three groups: Group A (14-day enteral nutrition), Group B (7-day enteral nutrition), and Group C (no supplementation). Nutritional status, laboratory parameters, postoperative complications, transfusion needs, and hospitalization metrics were compared among groups.</p><p><strong>Results: </strong>Group A demonstrated the most favorable outcomes, including significantly fewer postoperative complications such as anastomotic leakage (5.0% vs. 17.9%, p = 0.030), reduced transfusion and albumin requirements, and shorter ICU and hospital stays (1.6 ± 0.7 and 7.1 ± 2.4 days, respectively). Group C showed the highest complication and mortality rates. Improvements in biochemical markers were observed in both intervention groups, supporting the efficacy of enteral supplementation.</p><p><strong>Conclusion: </strong>Short-term preoperative enteral nutrition significantly improves clinical outcomes in malnourished colorectal cancer patients undergoing elective surgery. These findings support the integration of nutritional screening and intervention as standard components of perioperative care in oncologic surgery.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 3","pages":"227-232"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fully Digital Workflow for Immediate Prosthetic Implant on Microsurgery Fibula Flap for Mandibular Reconstruction.","authors":"Truong Dinh Van, Long Nguyen Khanh, Hieu Nguyen Dinh, My Hoang Phong, Chinh Cao Duc","doi":"10.5455/medarh.2025.79.215-219","DOIUrl":"10.5455/medarh.2025.79.215-219","url":null,"abstract":"<p><strong>Background: </strong>Immediate implant-retained surgery on the fibula using the traditional method is a technical challenge in mandibular reconstruction and can worsen the following prosthetic process. A digital workflow with multiple surgical guidance tools can help ensure accuracy and even immediate temporary prosthesis placement in mandibular reconstruction using fibula flaps.</p><p><strong>Objective: </strong>In this article, we present a digital workflow for dental implant placement in the fibula flap using a 3D-printed surgical guide before the vascularization of the flap and temporary prosthesis immediately during surgery.</p><p><strong>Case presentation: </strong>This procedure includes resection of the mandibular lesion, immediate reconstruction with a fibula flap, immediate implant placement, and provisional prosthesis placement. Our patient received both mandibular reconstruction and dental implant prosthesis completed in a single day at the tumor resection stage, which enormously shortens the recovery time without teeth to zero. Regarding the implant position on the fibula, the results were awe-inspiring. We measured and compared with the assumed plan; the neck deviation was about 1.47mm, the average change in implant height was 1.06mm, and the average implant deviation angle was 9.17 degrees. The above results helped the process of trying on temporary restorations and grinding the occlusion completely smoothly, even with the permanent restoration process later.</p><p><strong>Conclusion: </strong>We report two cases utilizing the fully digital \"Jaw in a Day\" workflow. VSP and surgical guidance are essential in the precise cutting and shaping of the fibula flap and the prosthetic restoration with dental implants.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 3","pages":"215-219"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-stratified Characterization of Body Composition and Biochemical Profiles in Cardiometabolic Risk Assessment.","authors":"Almedina Hajrovic Radovic, Sanela Hajro, Altaira Jazic Durmisevic, Melina Drljo, Aldina Alibegovic, Selma Sabotic- Klepo, Adela Erovic Vranesic, Amna Vefic, Dzenan Pleho, Arzija Pasalic","doi":"10.5455/medarh.2025.79.353-357","DOIUrl":"10.5455/medarh.2025.79.353-357","url":null,"abstract":"<p><strong>Background: </strong>Cardiometabolic risk (CMR), encompassing metabolic syndrome, type 2 diabetes mellitus, hypertension, and dyslipidemia, represents a major public health challenge in Bosnia and Herzegovina, where overweight and obesity prevalence is high.</p><p><strong>Objective: </strong>The study aimed to: a) examine the prevalence of three or more metabolic risk factors in relation to age; b) analyze biochemical parameters, lipid indices, and body composition indices in association with cardiometabolic risk (QRISK3); and c) identify age-specific thresholds for elevated risk.</p><p><strong>Methods: </strong>A cross-sectional, observational, descriptive-analytical study included 203 working-age participants (≤49, 50-54, 55-59, ≥60 years). The research instruments included: laboratory analysis, anthropometric and body composition parameters, and the Q3 risk calculator.</p><p><strong>Results: </strong>The prevalence of three or more metabolic risk factors increased with age, from <49 years to ≥60 years. Younger participants exhibited lower HDL and higher visceral fat, whereas older groups showed elevated glucose, ALT, and AST (p<0.05). The Q3 risk score increased significantly across age groups (median 8.15 to 24.80; p<0.001). Visceral fat, BMI, and body fat percentage emerged as strong predictors of risk in younger and middle-aged adults.</p><p><strong>Conclusion: </strong>Cardiometabolic risk develops already in early adulthood. Age-specific thresholds for visceral fat and biochemical markers may improve risk stratification, highlighting the importance of early screening and preventive interventions.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 5","pages":"353-357"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12634079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145590627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2D Speckle-tracking Echocardiography Parameters and Prognostic Performance of the Progression Among Patients with Stroke.","authors":"Diem Thi Nguyen, Nhan Huu Kha, Duy Huu Duong, Thuc Tri Nguyen, Cang Trung Huynh, Huy Gia Truong, Dung The Bui","doi":"10.5455/medarh.2025.79.358-364","DOIUrl":"10.5455/medarh.2025.79.358-364","url":null,"abstract":"<p><strong>Background: </strong>Stroke is the second leading cause of global mortality and the major contributor to morbidity. 2D speckle-tracking echocardiography (STE) is a sensitive method for evaluating myocardial function, but its parameters and prognostic value in stroke patients remain limited.</p><p><strong>Objective: </strong>The aim of this study was to evaluate the prognostic performance of left atrial and left ventricular function through the correlation of STE and tissue Doppler imaging (TDI) parameters.</p><p><strong>Methods: </strong>We conducted a prospective case-control study on 67 ischemic stroke patients who met inclusion criteria and underwent clinical evaluations, 2D echocardiography, TDI, and STE. We employed multivariate and univariate analyses to assess relationships, the area under the curve (AUC) and the receiver operating characteristic (ROC) curve to assess the prognostic performance of STE parameters.</p><p><strong>Results: </strong>In 67 stroke patients (55% men, 58 ± 10.1 years old) and 40 control patients (77.5% men, 43.75 ± 5.3 years old), correlation assessment regarding STE parameters, GLS and LAVmax in the two groups significantly declined from -18.6 ± 2.6 to -20.6 ± 1.3, 29.6 ± 8.5 to 24.6 ± 7.5, respectively. ROC curve analysis demonstrated high performance with AUC = 0.89, cut-off = 35.5%, sensitivity = 94.1% and specificity = 52%. Regarding multivariate logistic regression analysis, LAS indicated a significant relationship with severe stroke events (OR: 0.69, 95% CI 0.56 - 0.88, p = 0.001).</p><p><strong>Conclusion: </strong>The AUC of ROC showed STE parameters as a highly significant prognostic factor. After eliminating insignificant factors via a uni-multivariable logistic model, STE parameters remained a key factor in prognostic stroke progression.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 5","pages":"358-364"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12634095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145590625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-Exome Sequencing in Recurrent Pregnancy Loss: Current Evidence and Future Directions in Saudi Arabia.","authors":"Dalal Sameer Alshaer","doi":"10.5455/medarh.2025.79.488-496","DOIUrl":"10.5455/medarh.2025.79.488-496","url":null,"abstract":"<p><strong>Background: </strong>Recurrent pregnancy loss or RPL is a controversial subject in reproductive medicine. Although we perform clinical tests and cytogenetic analyses, we are often left puzzled. Whole-exome sequencing (WES) is changing this trend, whose usage has helped discover inherited and new genetic changes related to miscarriage.</p><p><strong>Objective: </strong>This review summarizes international experience of using WES in RPL diagnostics and genetics, particularly from Saudi Arabia and other consanguineous populations.</p><p><strong>Methods: </strong>Based on PRISMA protocols, database searches were performed in PubMed, Scopus, Embase, and Web of Science for published studies (2013 to 2025). There were 24 studies in total of women or couples with RPL which is due two or more consecutive losses with WES. Afterward, we sought information on the study design, participants, how WES was performed, its diagnostic yield, the genes involved, and the clinical implications. Studies from Saudi Arabia were evaluated in more detail.</p><p><strong>Results: </strong>A diagnostic yield of 34.9% was observed across these studies. A total of 24 studies with 585 families and 5,000 pregnancy losses. increasing further in trio-based WES designs. More than 60 genes were found that not only are responsible but also likely to contribute to RPL. Maternal effects, cilia development, immune tolerance, and blood coagulation-endocrine functions. Most cases were of autosomal-recessive mode of inheritance, particularly in consanguineous groups from Saudi Arabia and South Asia. European populations, however, were shown to have a more abundant de novo variants. In Saudi Arabia, genomic research has contributed significantly toward identifying novel maternal-effect and early embryonic genes that highlight the necessity of population-specific genomic data.</p><p><strong>Conclusion: </strong>WES is transforming the diagnosis of RPL by unveiling rare monogenic and oligogenic causes that would otherwise be missed by standard testing. The application of WES in reproductive health care facilitates counselling, PGTM and targeted carrier screening. These approaches can possibly improve outcomes and increase live births. The evidence from Saudi Arabia and other consanguineous populations suggests added advantages in the consanguineous context and points to ways that genomic medicine can aid reproductive choices. Future research should include functional validation of candidate variants, the use of AI-based tools for variant interpretation, and the establishment of global registries to promote equitable and population-informed genomics for future purposes.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 6","pages":"488-496"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Perioperative Neonatal and Maternal Glycemic Response and APGAR Score During Elective Cesarean Section: Factors and Anesthetic Management.","authors":"Diab A Bani Hani, Omar F Altal, Ala A A Alhowary, Anas Alrusan, Rania Al-Bataieneh, Khayria Tahir, Shahed Shloul, Malak Issa, Ahmed Al Sharie","doi":"10.5455/medarh.2025.79.34-40","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.34-40","url":null,"abstract":"<p><strong>Background: </strong>The type of anesthesia and intensity of pain experienced during surgery are linked to the body's stress response, as reflected in preoperative and postoperative glucose levels.</p><p><strong>Objective: </strong>This comparative study aims to assess the hyperglycemic stress response to cesarean sections performed under different types of anesthesia.</p><p><strong>Methods: </strong>This prospective study included 302 participants, divided into two groups: a general anesthesia group and a spinal anesthesia group. Our primary objective was to investigate the effects of general versus spinal anesthesia on pregnant women undergoing cesarean section. Secondarily, we aimed to assess the impact of other factors on the maternal and neonatal stress response during surgery.</p><p><strong>Results: </strong>Both groups exhibited a significant proportional increase in mean blood glucose levels after surgery. However, this increase was more pronounced in the general anesthesia group than in the spinal anesthesia group. Therefore, spinal anesthesia had a greater effect in attenuating the hyperglycemic response to surgery during cesarean section compared to general anesthesia. Maternal blood glucose levels were significantly associated with steroid injection, type of anesthesia, and gestational age. In contrast, neonatal blood glucose was significantly associated with gestational age, APGAR score, maternal steroid injection, type of anesthesia, maternal age, and both preoperative and postoperative maternal blood glucose levels.</p><p><strong>Conclusion: </strong>Spinal anesthesia was superior to general anesthesia in attenuating both maternal and neonatal hyperglycemic responses during the cesarean section. This highlights the significant impact of anesthesia type on maternal and neonatal well-being.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 1","pages":"34-40"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Abnormal Morphokinetic Embryos, Genetic Testing Results, and Clinical Outcomes.","authors":"Diem Thi Yen, Nguyen Khang Son, Nguyen Thi Hue Giang, Le Thi Quyen, Doan Nhu Tho, Tran Thi Dieu Thuy, Nguyen Xuan Hoi","doi":"10.5455/medarh.2025.79.4-8","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.4-8","url":null,"abstract":"<p><strong>Background: </strong>Embryo quality is a crucial factor in the success of in vitro fertilization (IVF). Morphokinetics, which refers to the timing and sequence of embryonic cell division and development, has gained attention as a potential indicator of embryo viability and genetic competence.</p><p><strong>Objective: </strong>This study evaluates the relationship between abnormal embryonic morphokinetics and genetic analysis results, and their impact on clinical outcomes in assisted reproductive technology (ART).</p><p><strong>Methods: </strong>Conducted at Duc Phuc Hospital with Hanoi Medical University from January to December 2023, the prospective study included 152 patients undergoing in-vitro fertilization (IVF). A total of 968 blastocysts were analyzed using preimplantation genetic testing for aneuploidy (PGT-A). Time-lapse monitoring assessed cell division milestones and abnormal morphokinetic patterns, including direct cleavage, reverse cleavage, multinucleation, and vacuole. Patients received a single euploid embryo transfer. Clinical outcomes were tracked to the live birth stage, analyzed using SPSS 20.0, with p-values < 0.05 considered significant.</p><p><strong>Results: </strong>Of 583 blastocysts, 294 (50.4%) showed abnormal cleavage patterns. The aneuploidy rate was higher in embryos with reverse cleavage (56.1%) and multinucleation (50%), while direct cleavage and vacuolization showed no significant correlation. Early blastocyst formation (≥100 hours) was linked to a higher aneuploidy rate (60.8%). Nonetheless, clinical outcomes, such as β-hCG positivity and live birth rates, were similar between abnormal and normal cleavage groups when euploid embryos were transferred.</p><p><strong>Conclusion: </strong>Abnormal morphokinetic patterns are linked to higher aneuploidy rates, but do not significantly affect clinical outcomes when euploid embryos are selected. Integrating genetic testing with morphokinetic assessment can optimize ART success rates.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 1","pages":"4-8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Profile of Addicts Treated in a Therapeutic Community.","authors":"Đana Loncarica, Jasmina Mahmutovic","doi":"10.5455/medarh.2025.79.369-373","DOIUrl":"10.5455/medarh.2025.79.369-373","url":null,"abstract":"<p><strong>Background: </strong>Perspectives and views on addiction have changed throughout history, from moralistic interpretations to pharmacological, medical, social and cultural approaches. Research and thinking about the connection between social development and the use of psychoactive substances has broadened the perspective. Personal factors that contribute to the development of a tendency towards addiction are extremely important for understanding addictive behavior, but they are less the focus of researchers. This is one of the key reasons why the underlying causes of this disease are still under-researched.</p><p><strong>Objective: </strong>To discover how psychological profiles differ between those who have successfully completed treatment and those who have not, thereby providing deeper insight into traits that may be key to successful rehabilitation of addicts.</p><p><strong>Methods: </strong>The study involved drug addicts (N=368) who were undergoing residential treatment for a year at the Therapeutic Community Institution, Campus of Canton Sarajevo. The study used the MMPI 2 - Minnesota Multiphasic Personality Inventory, a broad-ranging test designed to identify a number of major personality and emotional disorders, and a standardized questionnaire with basic data on addicts in the treatment program, the Pompidou questionnaire, which is used in many European countries to determine: the prevalence of substance abuse, the modality of their use, and the associated harmful consequences. After the psychological profiles were formed, we investigated whether there was a difference between the groups of addicts who completed treatment and those who did not. The IBM SPSS (v23.0) software for statistical analysis was used to process the collected data.</p><p><strong>Results: </strong>AGE - statistically significant differences/borderline differences were found on the scale Psychopathic Deviation (F=7.501 p=0.001), Paranoia (F=3.025, p=0.056), Psychoasthenia (F=3.144, p=0.051) and Schizophrenia (F=4.383, p=0.017). Status of previous treatment - statistically significant differences were found on the scales Psychopathic Deviation (F=6.047 p=0.017) and Masculinity-Femininity (F=5.086, p=0.028).</p><p><strong>Conclusion: </strong>Understanding the personality psychological profiles, sociodemographic characteristics, history of the disease of addiction can improve the understanding of the personality of the addict and help to be more successful in the treatment. Previous research in this area shows that addicts have additional psychological difficulties that should be addressed and treated during addiction treatment.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 5","pages":"369-373"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12634092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145589761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxic Conditioned Medium Secretome from Mesenchymal Stem Cell Alleviates Sepsis by Targeting IL-6 and IL-4.","authors":"Mutiara Indah Sari, Nelva Karmila Jusuf, Delfitri Munir, Agung Putra, Tatang Bisri, Syafruddin Ilyas, Farhat Farhat, Adi Muradi Muhar","doi":"10.5455/medarh.2025.79.365-368","DOIUrl":"10.5455/medarh.2025.79.365-368","url":null,"abstract":"<p><strong>Background: </strong>Sepsis is a state of immune response imbalance in an attempt to eliminate infection. Currently, the hypoxic conditioned medium (HPO-CM) secretome from mesenchymal stem cells (MSCs) has been considered as a therapeutic approach with their immunomodulatory capabilities.</p><p><strong>Objective: </strong>The aim of this article was to study the effect of HPO-CM secretome on the levels of IL-6 and IL-4 in the rat model of sepsis.</p><p><strong>Methods: </strong>Forty-eight male Rattus norvegicus rats aged 10-12 weeks were divided into four groups: sham (no sepsis induction and treatment), control (sepsis induction without treatment), T1 (sepsis induction and treated with 150 µL of HPO-CM secretome), and T2 (sepsis induction and treated with 300 µL of HPO-CM secretome). Sepsis was induced with procedures based on previous studies. Forty-eight hours after sepsis induction, we sacrificed the rats and collected the blood from the rat orbitals to examine the serum IL-6 and IL-4 levels.</p><p><strong>Results: </strong>A significant decrease in IL-6 levels was found in rats given 150 µL and 300 µL of HPO-CM secretome. Meanwhile, a significant increase in IL-4 levels was found in rats given 300 µL of HPO-CM secretome.</p><p><strong>Conclusion: </strong>HPO-CM secretome can alleviate immune dysregulation in sepsis by reducing serum IL-6 levels and increasing serum IL-4 levels.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 5","pages":"365-368"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12634072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145590669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}