Medical archives (Sarajevo, Bosnia and Herzegovina)最新文献

{"title":"Live Birth Rate After Transfer of a Single Euploid Blastocyst With and Without a Multinucleated Embryo.","authors":"Diem Thi Yen, Nguyen Thi Hue Giang, Le Thi Quyen, Tran Thi Dieu Thuy, Doan Nhu Tho, Luong Thi Van Anh, Vu Duong Thanh, Luong Xuan Huy, Pham Quang Nhat, Vo Minh Tuan, Nguyen Xuan Hoi, Nguyen Khang Son","doi":"10.5455/medarh.2025.79.292-295","DOIUrl":"10.5455/medarh.2025.79.292-295","url":null,"abstract":"<p><strong>Background: </strong>Multinucleation, a deviation from typical embryonic development, is frequently observed during in vitro fertilization (IVF) cycles. The relationship between multinucleation at the two-cell stage (2MN), chromosomal status, and live birth remains poorly defined.</p><p><strong>Objective: </strong>This study aimed to investigate whether 2MN is associated with chromosomal status, determined by preimplantation genetic testing for aneuploidy (PGT-A), and live birth outcomes following single embryo transfer.</p><p><strong>Methods: </strong>This prospective study, conducted from January 2023 to December 2023, included 152 patients undergoing IVF. Oocytes were cultured and monitored in a time-lapse system, and blastocysts were analyzed by PGT-A.</p><p><strong>Results: </strong>23.3% of embryos exhibited 2MN. Euploidy rates were significantly lower in the 2MN group (36.0%) compared to the non-multinucleation group (46.3%) (p < 0.05), and mosaicism was significantly more frequent in the 2MN group (42.6% vs. 31.1%, p < 0.05). However, live birth rates following euploid embryo transfer did not differ significantly between the non-multinucleation group (61.8%) and the multinucleation group (62.3%) (p > 0.05).</p><p><strong>Conclusions: </strong>While 2MN is associated with reduced euploidy rates and increased mosaicism, euploid embryos with early multinucleation have comparable live birth rates to non-multinucleated embryos. A limitation of the study was the relatively small sample size for the live birth outcome subgroup.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 4","pages":"292-295"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Outcomes and Prognostic Factors for Resectability of Intramedullary Spinal Cord Tumors Incorporating Intraoperative Neurophysiological Monitoring In Vietnam.","authors":"Tran Son Tung, Duong Dai Ha, Le Hong Nhan, Nguyen-Anh Tuan","doi":"10.5455/medarh.2025.79.280-286","DOIUrl":"10.5455/medarh.2025.79.280-286","url":null,"abstract":"<p><strong>Background: </strong>Surgery is the preferred treatment for symptomatic intramedullary lesions. Intraoperative neurophysiological monitoring (IONM) has recently emerged as a crucial tool in spinal surgery, enhancing safety through real-time assessment of spinal cord function. Its use is particularly beneficial during intramedullary tumor resection, helping to reduce the risk of neurological impairment and improve postoperative outcomes.</p><p><strong>Objective: </strong>Our study aims to evaluate the efficacy and outcomes of intraoperative neurophysiological monitoring for intramedullary tumor resection surgery in Vietnam and to identify some key predictive factors for tumor resectability.</p><p><strong>Methods: </strong>A prospective study on 41 patients treated with neurosurgery using multimodal intraoperative neurophysiological monitoring between January 2022 and February 2024 at the Neurosurgery Center, Hanoi, Viet Nam.</p><p><strong>Results: </strong>Gross total tumor resection was achieved in 26/41 patients (63.4%) with the mean tumor length was 49.9 mm. Among them, 21 cases (51.2%) were ependymoma, 15 cases (36.6%) were diffuse gliomas and 5 cases (12.2%) were other types (including hemangioblastoma, and metastases). Early outcomes assessed at 6 months using the modified McCormick Scale (MCS) revealed that 23.1 % showed no change, 76.9% patients demonstrated improvement. Univariate demonstrated intraoperative motor evoked potentials (MEPs) changes, tumor length and tumor transverse diameter were predictive factors for the resectability; preoperative McCormick Scale and somatosensory evoked potentials (SSEPs) changes were predictors for postoperative outcomes. Multivariate analysis revealed that tumor length was the only independent factor predicting tumor resectability.</p><p><strong>Conclusion: </strong>Our study demonstrated the efficacy of IONM in improving surgical outcomes for patients undergoing intramedullary tumor resection. The outcomes of patients with intramedullary tumors post-surgery with IONM were significantly affected by the preoperative McCormick Scale and SSEPs changes during surgery. Predictive factors for resectability were tumor size in preoperative Magnetic Resonance Imaging (MRI) and intraoperative MEPs changes.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 4","pages":"280-286"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Anemia As a Predictor of Postoperative Delirium in Patients With Colorectal Cancer.","authors":"Dzenita Ahmetasevic, Selmira Brkic, Jasmina Smajic, Alisa Krdzalic","doi":"10.5455/medarh.2025.79.301-304","DOIUrl":"10.5455/medarh.2025.79.301-304","url":null,"abstract":"<p><strong>Background: </strong>Relationship between preoperative anemia (PA) and postoperative delirium (POD) is not still completely clear and totally proven for surcigally treated patients. This study tries to unveil that connection in patient surgically treated for colorectal cancer (CRC).</p><p><strong>Objective: </strong>The aim of this study is to examine relationship between PA and POD in patients surgically treated for CRC and improve preoperative preparation and recognition of critical risk groups of patients for POD.</p><p><strong>Methods: </strong>Out of 62 patient were analysed in prospective method. All patient have been operated for CRC in Surgical clinic of University clinical centre Tuzla from june until december of 2024. Patients were divided in 2 groups depending on presence of PA. Presence of PA is defined as blood hemoglobin concentration (HGB) lower than 130 g/L (<13 g/dL) or hematocrite (HCT) lower than 39% in grown up men and HGB <120 g/L (<12 g/dL) or HCT<37% in grown up women. Incidence of POD was observed and noted postoperatively. POD was diagnosed and confirmed with CAM test (Confusion Assessment Method), which was done inside first 2 hours after surgery and patient extubation. Noted datas were analysed with descriptive and analytic statistic methods.</p><p><strong>Results: </strong>POD incidence was 27% (17/62) on the first postoperative day. After analysis statitically significant realtionship was found between PA and POD (ρ=0.324; p<0.05). Realised corellation is on the significance level of 0.05 (95%), it has positive direction and waek intensity. POD occurs 4,5 times more often in patients with PA. (OR= 4,500; 95% IP: 1.355-14.944).</p><p><strong>Conclusion: </strong>PA is connected with increased number of patients with POD who have been surgically treated for CRC. PA can be defined as one important preoperative risk factor that affect onset of POD . Identification of all preoperative risk factors and its correction represent best way of POD prevention.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 4","pages":"301-304"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trachoma in Croatia: How Did it Become a Thing of the Past?","authors":"Jelena Juri Mandic, Maja Bakula, Lorena Karla Sklebar, Ivana Gabric, Kresimir Mandic, Snjezana Kastelan, Zdenko Bujger","doi":"10.5455/medarh.2025.79.320-323","DOIUrl":"10.5455/medarh.2025.79.320-323","url":null,"abstract":"<p><strong>Background: </strong>Trachoma is a specific type of keratoconjunctivitis caused by bacteria Chlamydia trachomatis and characterized by conjunctival follicular and papillary hyperplasia, followed by conjunctival scarring, entropion, trichiasis and corneal ulcerations.</p><p><strong>Objective: </strong>The aim of this article is to describe the successful epidemiological programs and actions which led to eradication of trachoma in Croatia.</p><p><strong>Methods: </strong>Online literature search conducted with the purpose of identifying studies describing epidemiological methods of eradicating trachoma in Croatia.</p><p><strong>Results: </strong>In an effort to eradicate trachoma in Croatia, many medical and epidemiological actions were taken in the middle of the 20th century. At the time, throughout infected areas antitrachoma stations were founded, in form of an outpatient clinic office with a trained ophthalmologist and a nurse who would continuously treat and monitor trachoma patients. Special attention was given to screening and treatment of school-aged children and special programs were developed for their treatment. Many adults were treated in form of an intermittent treatment. Epidemiologists and ophthalmologists also organized regular screenings of the whole population in the infected areas. These screenings were conducted jointly with educational activities which consisted of simplified informative posters, brochures, flyers, and films.</p><p><strong>Conclusion: </strong>Success of trachoma treatment in Croatia in the middle of the 20th century was a result of a combination of a well-organized epidemiological programs and actions throughout the infected areas, which included educational programs, adequate treatment of local population and improvement of hygiene and living conditions. We hope that this historical review could help in planning and implementing the eradication of the most common infectious cause of blindness in low to mid income countries still nowadays.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 4","pages":"320-323"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Main Blood Supply for The Nipple-Areola Complex of Breast Hypertrophy Evaluated by Multi-Slice Computed Tomography.","authors":"Ta Thi Hong Thuy, Tran Thiet Son, Pham Thi Viet Dung, Luu Hong Nhung, Lai Thu Huong, Phan Tuan Nghia","doi":"10.5455/medarh.2025.79.267-270","DOIUrl":"10.5455/medarh.2025.79.267-270","url":null,"abstract":"<p><strong>Background: </strong>Breast hypertrophy is a condition of increased breast volume, occurring at different ages, causing many psychological and physiological problems such as back pain, inflammation of the inframammary folds, and psychological stress1.</p><p><strong>Objective: </strong>This study aimed to identify the main arterial sources of blood supply to the nipple-areola complex (NAC), which may apply to extensive hypertrophic breast reduction surgeries.</p><p><strong>Methods: </strong>Describe a cross-sectional, uncontrolled clinical case series to evaluate the most accurate blood supply to the NAC based on angiography for all patients diagnosed with excessive breast enlargement requiring surgery.</p><p><strong>Results: </strong>30 female patients were diagnosed with hypertrophic breasts with a minimum volume of 1005cc and a maximum of 2412 cc. Multi-slice computed tomography (MSCT) was indicated preoperatively to determine the blood supplies to the breast; the internal mammary artery (IMA) predominates in 60/60 breasts (100%), and the lateral thoracic artery predominates in 21/60 breasts (35%). Based on the MSCT scan results, the axial flap design carrying the NAC complex has a dominant branch entirely from the IMA: superior medial pedicle in 48/60 breasts (80%), superior pedicle in 11/60 breasts (18.33%) and medial pedicle in 1/60 breasts (1.67%). None of the breasts showed signs of nipple-areola necrosis after surgery, and only two cases (3.3%) of partial NAC necrosis occurred, both in superior flaps.</p><p><strong>Conclusion: </strong>Preoperative breast MSCT imaging helps select the type of pedicle that supplies blood to the NAC and minimizes the risk of NAC necrosis during breast reduction surgery in cases of significant hypertrophy and severe grades of ptosis.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 4","pages":"267-270"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Silent Mimic: Actinomyces and the Enigmatic Gastric Ulcer.","authors":"Annisa Zahra Mufida, Muhammad Miftahussurur","doi":"10.5455/medarh.2025.79.328-330","DOIUrl":"10.5455/medarh.2025.79.328-330","url":null,"abstract":"<p><strong>Background: </strong>Primary gastric actinomycosis is a rare infection caused by anaerobic Actinomyces species, normally colonizing the oral and gastrointestinal flora. Often misdiagnosed as malignancy due to atypical presentation and non-specific findings, it typically affects immunocompromised individuals or those with mucosal damage from surgery or trauma.</p><p><strong>Objective: </strong>The aim of this case report is to explore the diagnostic challenges and the necessity of high clinical suspicion for rare infectious causes of gastrointestinal pathology, especially given its atypical presentation.</p><p><strong>Case presentation: </strong>A 63-year-old woman presented with hematemesis, melena, and epigastric pain. Laboratory tests revealed severe anaemia, hypoalbuminemia, and elevated cancer antigen 19-9 (CA 19-9). Gastroscopy revealed oesophageal erosions and a gastric ulcer with a wide, black-coloured base on a polypoid lesion, along with small erosions. Histopathological findings showed filamentous and rod-like bacteria, consistent with Actinomyces, in gastroscopic biopsies. The patient was then treated with high-dose intravenous penicillin G. <b>Conclusion:</b> This case highlights the diagnostic challenges of gastric actinomycosis, which can be mistaken for peptic ulcers or malignancy. Clinicians should consider gastric actinomycosis, especially in immunocompromised patients, when imaging or endoscopy reveals a submucosal lesion or ulcer.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 4","pages":"328-330"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Date Consumption on Labor and Vaginal Birth.","authors":"Mohammad Abou El-Ardat, Zarema Obradovic, Dzenana Saldo, Minela Velagic, Aida Omeragic, Nedim Galijasevic","doi":"10.5455/medarh.2025.79.56-60","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.56-60","url":null,"abstract":"<p><strong>Background: </strong>Date palm fruits (Phoenix dactylifera L.) are a widely available product that contains numerous macronutrients including a high sugar content. Research has shown that date fruit extracts possess antibacterial and antifungal properties, as well as antimutagenic and antiatherogenic effects. Date fruit can also have a beneficial effect on the female reproductive system. Several studies have examined the impact of date consumption during pregnancy on the outcome of labor, providing useful results.</p><p><strong>Objective: </strong>This study aims to determine the effects of date fruit consumption on the onset and progression of labor.</p><p><strong>Methods: </strong>The study included 120 pregnant women who were pregnant at GAK Sarajevo, in the period from 01.01. 2020 to 31.12. 2020. The patients were divided into two groups, the first group of 60 patients who consumed 6 dates during the last four weeks of pregnancy, and the second group of 60 patients who did not consume dates during pregnancy.</p><p><strong>Results: </strong>There was a significant positive effect of consuming date fruits on maternal outcomes in the first and third stages of labor. The group of pregnant women who consumed dates had a shortened latent phase of labor, which meant that their cervix reached maximum dilation (10 cm) faster. Pregnant women in this group gave birth 8.5 hours faster than pregnant women who did not consume dates, in whom labor lasted about 15 hours. Of the 60 pregnant women in the first group, 60% had a spontaneous natural birth, and only 40% of the patients received oxytocin, because dates enhance the effect of oxytocin, which is responsible for uterine contractions.</p><p><strong>Conclusion: </strong>This study showed a promising effect of consuming date fruits on the duration of the stages of labor. Saturated and unsaturated fatty acids found in dates stimulate the production of prostaglandins, which are necessary for labor. Dates are also rich in folic acid, vitamin K, iron, potassium, and magnesium.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 1","pages":"56-60"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Beneficial Effect of Melatonin on Gentamicin-induced Liver Injury in Rats.","authors":"Mersiha Krupalija-Fazlic, Dina Kapic, Maida Sahinovic, Samra Custovic, Visnja Muzika","doi":"10.5455/medarh.2025.79.86-91","DOIUrl":"10.5455/medarh.2025.79.86-91","url":null,"abstract":"<p><strong>Background: </strong>Gentamicin is a potent, broad-spectrum aminoglycoside antibiotic used in the treatment of many infections. Gentamicin can induce hepatotoxicity through oxidative stress and apoptosis. Since melatonin has antioxidant properties, its protective effects on liver tissue damage were evaluated in this study.</p><p><strong>Objective: </strong>The aim of this study was to conduct our investigation to assess the hepatoprotective effects of melatonin in rats treated with gentamicin.</p><p><strong>Methods: </strong>Forty eight adult male Wistar rats were used. The animals were randomly distributed into six groups of equal size. During the period of 11 days, three control groups of rats were daily injected i.p. with the vehicle or with melatonin at a dose of 5 or 10 mg/kg. The gentamicin group was injected with gentamicin at a dose of 80 mg/kg during 8 days and vehicle for 11 days. The other two experimental groups were administered gentamicin (80 mg/kg during) 8 days and melatonin (doses of 5 and 10 mg/kg) 3 days before and 8 days concomitantly with melatonin. Obtained liver sections were analyzed using qualitative, semi-quantitative, and stereological analysis.</p><p><strong>Results: </strong>Gentamicin expressed hepatotoxic effects inducing congestion of lobular blood vessels, hydropic degeneration of periportal hepatocytes and mononuclear infiltration in the portal tract. Treatment with gentamicin resulted in an increase in the Vv of blood vessels, a decrease in the Vv of hepatocytes, and a decrease in the glycogen content in all three lobular zones. Melatonin administration reduced the liver alterations induced by gentamicin; the higher dose had a more potent protective effect.</p><p><strong>Conclusion: </strong>Melatonin has a beneficial effect on gentamicin-induced liver damage and the effect is dose-dependent.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 2","pages":"86-91"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthroscopic Management of Triangular Fibrocartilage Complex Injuries: Clinical Outcomes and Functional Results in a Vietnamese Population.","authors":"DaoXuan Thanh, Bui HongThien Khanh, Le Trong Tan, TranNguyen Phuong","doi":"10.5455/medarh.2025.79.100-104","DOIUrl":"10.5455/medarh.2025.79.100-104","url":null,"abstract":"<p><strong>Background: </strong>Triangular fibrocartilage complex (TFCC) injuries commonly cause ulnar-sided wrist pain, yet reports on arthroscopic management outcomes in Asian populations remain limited.</p><p><strong>Objective: </strong>This study evaluates clinical outcomes following arthroscopic treatment of TFCC injuries in Vietnamese patients.</p><p><strong>Methods: </strong>This prospective study included 40 patients (60% female, mean age 32.6±8.6 years) with TFCC injuries treated arthroscopically between January 2021 and December 2022. Preoperative assessment included Visual Analog Scale (VAS) pain evaluation, Modified Mayo Wrist Score (MMWS), Disabilities of the Arm, Shoulder, and Hand (DASH) scores, physical examination, and MRI. Surgical techniques included debridement (17.5%), capsular repair (57.5%), and transosseous repair (25.0%). Patients were evaluated at 1, 3, and 6 months postoperatively.</p><p><strong>Results: </strong>Type 1B tears (62.5%) were most common. MRI diagnosis matched intraoperative findings in only 42.5% of cases. Mean VAS pain scores improved from 6.90±1.57 preoperatively to 1.03±1.44 at 6 months (p<0.001). MMWS scores improved from 51.50±12.57 to 88.38±10.15, with 87.5% of patients achieving good or excellent results. DASH scores decreased from 38.73±15.93 to 9.23±8.62 (p<0.001). Complications occurred in 15% of patients, primarily transient ulnar nerve symptoms. No significant outcome differences were observed between surgical techniques. Patient satisfaction was high (92.5%).</p><p><strong>Conclusion: </strong>Arthroscopic management of TFCC injuries in Vietnamese patients demonstrates excellent short-term outcomes regardless of surgical technique. The discrepancy between MRI and arthroscopic findings highlights the importance of thorough arthroscopic evaluation.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 2","pages":"100-104"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Serological Predictors of Liver Fibrosis in Vietnamese Chronic Hepatitis B Patients with Persistently Normal or Mildly Elevated Aminotransferase Level.","authors":"Tien Duc Dao, Hieu Van Tran, Khai Hoang Nguyen, Khien Van Vu","doi":"10.5455/medarh.2025.79.147-154","DOIUrl":"10.5455/medarh.2025.79.147-154","url":null,"abstract":"<p><strong>Background: </strong>Chronic hepatitis B (CHB) remains a significant health concern, especially in low- and middle-income countries. Some CHB patients with normal or mildly elevated ALT may have advanced liver fibrosis, which often goes undetected.</p><p><strong>Objective: </strong>The aim of this study was to assess the prevalence of significant fibrosis and the diagnostic accuracy of serum markers in CHB patients with ALT <2× ULN in Vietnam.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at 175 Military Hospital between October 2019 and December 2021. A total of 144 CHB patients with ALT <2× ULN were assessed for liver fibrosis using FibroScan (METAVIR criteria). The diagnostic accuracy of APRI and FIB-4 was evaluated using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>Among 144 participants, 26.4% exhibited advanced fibrosis (F≥2), including 9% with cirrhosis. Advanced fibrosis correlated with older age (50 vs. 42 years, p=0.012), male sex (p=0.024), higher AST, ALT, and GGT levels (p<0.05), and lower platelet counts (PLT) (p<0.001). APRI and PLT demonstrated the highest diagnostic accuracy (AUC=0.802 and 0.805, respectively). APRI achieved 84.2% sensitivity and 92.5%, negative predictive value (NPV), while PLT had the highest specificity (81.1%). FIB-4 (AUC=0.716), ALT (AUC=0.676), and prothrombin time (PT) (AUC=0.646), had moderate performance. Combining APRI and PLT significantly improved diagnostic accuracy (p<0.05).</p><p><strong>Conclusion: </strong>Significant fibrosis was present in 26.4% of CHB patients with normal or mildly elevated ALT levels. APRI and PLT are reliable and cost-effective to detect early fibrosis in re-source-limited settings. These findings underscore the need to revise Vietnam's CHB management strategies for earlier fibrosis diagnosis and treatment.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 2","pages":"147-154"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}