Medical archives (Sarajevo, Bosnia and Herzegovina)最新文献

{"title":"Serum Concentrations of IL-18, IL-21, IL-22, IL-23, IL-27, and IL-31 in Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis and Their Correlation With Disease Severity.","authors":"Tran Thi Huyen, Nguyen Hoang Phuc, Pham Thi Lan, Le Huyen My, Nguyen Thi Ha Vinh, Dao Anh Son, Le Huu Doanh","doi":"10.5455/medarh.2025.79.9-14","DOIUrl":"https://doi.org/10.5455/medarh.2025.79.9-14","url":null,"abstract":"<p><strong>Background: </strong>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening conditions marked by extensive epidermal necrolysis and skin sloughing.</p><p><strong>Objective: </strong>The study aimed to assess the serum levels of specific proinflammatory interleukins (IL-18, -21, 22, -23, -27, and -31) and their relationship with the severity of SJS/TEN within the Vietnamese population.</p><p><strong>Methods: </strong>This descriptive cross-sectional study was conducted from 2018 to 2020. Serum levels of IL-18, -21, -22, -23, -27, and -31 were measured using the fluorescence covalent microbead immunosorbent assay.</p><p><strong>Results: </strong>The study included 61 patients (29 males and 32 females; 21 with SJS and 40 with TEN), with a median age of 51 years (interquartile range: 37-58), and 20 healthy controls. The median lesional area covered 45% of the body surface area (interquartile range: 8-70%). The most frequently identified medications were traditional medicine (19 patients; 31.15%), allopurinol (9 patients; 14.75%), and carbamazepine (8 patients; 13.11%). In the TEN group, the serum level of IL-18 was significantly elevated compared to the healthy control group. A correlation was found between serum levels of IL-18 and IL-27 and the lesional area in SJS/TEN patients, as well as between serum levels of IL-18 and IL-31 and the lesional area in TEN patients.</p><p><strong>Conclusion: </strong>Serum levels of IL-18 were increased in TEN group. Additionally, serum concentrations of IL-18, IL-27, and IL-31 were associated with disease severity as indicated by the lesional area. These interleukins may play an important role in the pathogenesis of SJS/TEN.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 1","pages":"9-14"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Analgesic Effect of Nefopam in Patients Undergoing Orthopedics Surgery with Tourniquet: a Double-blind Case-control Trial.","authors":"Anas Alrusan, Suhaib Bani Essa, Ala A Alhowary, Diab Bani Hani, Mohammad Al Hazaymeh, Mohammad Alradaideh, Halah Alameri, Ahmad Bani Younes, Noor Al-Badarneh, Saba Alradaideh","doi":"10.5455/medarh.2025.79.205-210","DOIUrl":"10.5455/medarh.2025.79.205-210","url":null,"abstract":"<p><strong>Background: </strong>Pain-free and relief are one of the anesthesiologist's most important concerns during the operation. General aim is always to effectively control pain but while simultaneously reducing opioid requirements to reduce opioid related side effects and mortality. Patients undergoing orthopedic operations tend to have high pain scores and analgesic requirements.</p><p><strong>Objective: </strong>In this study, we aim to investigate the effect of adding nefopam on reducing the postoperative pain scores and the need for opioids.</p><p><strong>Methods: </strong>This double-blind placebo-controlled prospective study aims to determine the effectiveness of nefopam in relieving the pain resulting from the operation in addition to the pain resulting from tourniquet. The unlabeled drug solution was administered one at the beginning of surgery. A 10 mL solution containing nefopam 20 mg or placebo diluted with normal saline was infused over 20 min. 11-point visual analogue scale was utilized to assess the pain score.</p><p><strong>Results: </strong>Forty-nine participants enrolled in the study, 24 received nefopam. The mean age was 40.45 years. Participants received nefopam achieved better postoperative surgical site pain score, less intraoperative and postoperative opioids use. Nefopam utilization was the single independent factor affecting the postoperative pain score.</p><p><strong>Conclusions: </strong>Compared with placebo, opioid requirement was decreased, the pain resulting from operation and tourniquet pain were decreased.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"79 3","pages":"205-210"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Approach to Patient Engagement in Obtaining Dental Services.","authors":"Yerbol Duisebayev, Mairash Baimuratova, Bassymbek Dilbarkhanov, Bakhyt Omarova, Kairat Zhakipbekov","doi":"10.5455/medarh.2024.78.232-240","DOIUrl":"10.5455/medarh.2024.78.232-240","url":null,"abstract":"<p><strong>Background: </strong>The comprehensive approach to involving patients in receiving dental services in Kazakhstan is highly relevant in the present time due to several key reasons. National health, economic advantages, quality of life, education and enlightenment, modern challenges, and the development of the dental industry all play a crucial role.</p><p><strong>Objective: </strong>The purpose is to investigate a comprehensive approach to involving patients in receiving dental services in Kazakhstan.</p><p><strong>Methods: </strong>To achieve this purpose, various methods, statistical analysis of data, and comparative analysis were used in the study. The combination of these methods provided a comprehensive understanding of the problem of patient involvement in dental services in Kazakhstan and developed realistic strategies to address it.</p><p><strong>Results: </strong>As a result, the level of involvement of patients in dental services in various regions of Kazakhstan was analysed. This allowed identifying the most active and less active areas of involvement and highlighting factors influencing the level of patient participation. The main obstacles and issues preventing patients from receiving dental care or leading to their negative attitude toward dental medicine were identified. Best practices and strategies for involving patients in dental services used in other countries or regions were analysed. This allowed the identification of successful approaches that can be adapted and implemented in the context of Kazakhstan.</p><p><strong>Conclusion: </strong>This study contributes valuable knowledge and recommendations to the field of dental medicine, helping to optimise the processes of providing dental services, which ultimately can enhance the nation's health and reduce healthcare costs.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 3","pages":"232-240"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Pirdot Leaf Extract (Saurauia Vulcani Korth ) on SGPT and SGOT Value in Wistar Strain Rats Induced by Salmonella Typhimurium.","authors":"Haslinda Haslinda, Yunita Sari Pane","doi":"10.5455/medarh.2024.78.9-11","DOIUrl":"10.5455/medarh.2024.78.9-11","url":null,"abstract":"<p><strong>Background: </strong>Typhoid fever is an acute disease caused by Salmonella typhimurium that can invade the liver and cause symptoms of hepatomegaly,jaundice.Biochemically, these symptoms can be assessed by seeing the SGPT and SGOT levels increase. Pirdot Leaf is an herbal plant found in the Toba area of North Sumatra which has a lot of bioactive potential,namely flavonoids,steroids, saponins. Flavonoids are active substances that can overcome the inflammatory process, it is expected that the administration of Pirdot leaf extract can reduce levels of SGOT and SGPT in mice induced Salmonella Typhimurium.</p><p><strong>Objective: </strong>The purpose of this study was to determine the effect of ethanol extract of pirdot leaves on SGPT and SGOT values in rat models induced by Salmonella typhimurium. Methods: This study used 32 samples divided into four groups namely: Normal group, Negative group, Positive group and Treatment group. Results: The results were obtained for normal control SGPT (27,85) negative control (37,80) positive control (27,30) and for Dick treatment (26,21). The results of the study for SGPT obtained normal control (73,18), negative control (120,23), positive control (92,89), and treatment control (78,68).</p><p><strong>Conclusion: </strong>Giving ethanol extract of pirdot leaves effect on reducing SGPT and SGOT levels in wistar strain mice induced Salmonella typhimurium.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 1","pages":"9-11"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Subtalar Dislocations: Insights from a Case Study and Literature Review.","authors":"Alzahid Abdullah, Alghamdi Mohannad, Alkhadra Faisal, Almulihi Qasem, Assiri Mohammed, Almulhim Mohammed, Alhawas Abdulaziz","doi":"10.5455/medarh.2024.78.71-74","DOIUrl":"10.5455/medarh.2024.78.71-74","url":null,"abstract":"<p><strong>Background: </strong>Isolated subtalar joint dislocations without associated fractures are rare in the medical literature. They occur when the talus bone remains in place while the calcaneus and navicular bones shift out of place. These dislocations account for about 15% of talus bone injuries and 1 to 2% of all joint dislocations. They are more common in young men following inversion trauma.</p><p><strong>Objective: </strong>This study aims to improve the understanding of diagnosis, treatment, and management of these rare injuries for better patient care.</p><p><strong>Case presentation: </strong>17-year-old male patient with type 1 diabetes mellitus presented to the emergency department with severe ankle pain and swelling following an inversion injury, which rendered him unable to walk or stand. Despite his chronic condition, he was hemodynamically stable, with no neurovascular deficits but an apparent deformity in the left ankle. Treatment involved pain management with morphine, successful closed reduction under ketamine sedation, and immobilization. Follow-up radiographs and a CT scan revealed no fractures but indicated soft tissue edema, joint effusion, and subsequent osteopenia. At a three-month follow-up, the patient experienced ongoing pain and weight-bearing difficulties, diagnosed as complicated pain syndrome requiring further physiotherapy and rehabilitation.</p><p><strong>Conclusion: </strong>This case highlights the clinical challenges and complications in managing isolated subtalar joint dislocations, particularly in patients with systemic health issues, and contributes valuable insights to the sparse literature on this topic.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 1","pages":"71-74"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metaplastic Breast Cancer with Squamous Differentiation: Beyond the Recognized Statistics.","authors":"Rania Zaki Fallatah, Dhuha N Boumarah, Ghadeer Hajjaj, Abdullah Ahmed Alkhars, Mohammed AlDuhileb","doi":"10.5455/medarh.2024.78.75-77","DOIUrl":"10.5455/medarh.2024.78.75-77","url":null,"abstract":"<p><strong>Background: </strong>Metaplastic breast cancer is a clinically rare subtype of breast carcinomas, accounting for less than 1% of all breast neoplasms, and was not officially recognized till the end of the 20th century as an independent pathological diagnosis.</p><p><strong>Objective: </strong>In this paper, we report a case of metaplastic breast cancer with squamous differentiation in a 51-year-old female, with a succinct review of the literature.</p><p><strong>Case report: </strong>The patient presented to our outpatient department with a complaint of left breast mass for 2 months duration with a diagnostic workup found to be grade three metaplastic carcinoma with squamous differentiation. The management decision was to proceed with neoadjuvant chemotherapy, followed by surgical intervention based on the tumor cell response to neoadjuvant therapy.</p><p><strong>Conclusion: </strong>Metaplastic breast cancer represents a rare clinical entity, encountered in a minority of patients. The clinical presentation of metaplastic carcinomas in general is similar to other breast cancers, however, metaplastic breast cancer tend to present in later stages as a rapidly growing mass with poor prognosis. The recognized poor prognosis along with rarity necessities having a high index of suspicion for early detection and appropriate management of metaplastic breast cancer.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 1","pages":"75-77"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Highly Rare Complication: Right Obturator Artery Pseudoaneurysm in a Crohn's Disease Patient Due to Multiple Perianal Abscesses and Drainages.","authors":"Mohammed M Al-Ghamdi, Ahmed Albaqshi, Khwaja Junaid Saeed, Tarig Adlan, Zakaria AlSafran, Hassan Alsayegh","doi":"10.5455/medarh.2024.78.241-243","DOIUrl":"10.5455/medarh.2024.78.241-243","url":null,"abstract":"<p><strong>Background: </strong>Obturator artery pseudoaneurysm is a rare entity, typically caused by trauma or iatrogenic injury during pelvic procedures. It is associated with symptoms such as pain, swelling if the aneurysm is large, and anemia.</p><p><strong>Objective: </strong>To report the first documented case of obturator artery pseudoaneurysm as a complication of perianal involvement in a patient with Crohn's disease, detailing the diagnostic approach and therapeutic interventions to highlight the importance of considering vascular complications in patients with complex perianal diseases.</p><p><strong>Case presentation: </strong>A 39-year-old male with long-standing Crohn's disease affecting the perianal region, and a history of multiple surgical drainages for perianal abscesses, presented to the emergency room with minimal bloody discharge from a perianal fistula. He was vitally stable and thus, perianal MRI was booked on routine bases, revealing a large cystic lesion near the perineum, showing intense enhancement post IV contrast administration. Subsequent imaging confirmed the diagnosis of an obturator artery pseudoaneurysm. The patient underwent successful management via percutaneous trans-arterial embolization, recognized as a safe and effective treatment for such cases.</p><p><strong>Conclusion: </strong>This case is the first in the literature reporting an obturator artery pseudoaneurysm in a patient with Crohn's disease. It underscores the necessity of vigilance for vascular complications in patients with extensive perianal Crohn's disease, offering significant educational value for improving outcomes in similar clinical scenarios.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 3","pages":"241-243"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Patterns and Quality of Acute Trauma Care in A University Hospital - A 5-year Analysis.","authors":"Omar A Bamalan, Ahmed A Alshaikhi, Nader M Alosaimi, Mamoun A Nabri, Adel J Osman, Humood A Alsadery, Ayman O Nasr","doi":"10.5455/medarh.2024.78.226-231","DOIUrl":"10.5455/medarh.2024.78.226-231","url":null,"abstract":"<p><strong>Background: </strong>Traumatic injuries contribute to over 5 million fatalities each year and cause a significant burden on healthcare systems' resources and availability. Traumatic injury patterns and a healthcare system's efficiency are critical to predicting patients' outcomes and should be regularly evaluated to deliver optimum care.</p><p><strong>Objective: </strong>The study will present and discuss trauma qualty indicators (TQI's) to display the local practices' opportunities for improvement and analyze patterns of traumatic injuries and outcomes.</p><p><strong>Methods: </strong>The study retrospectively analyzed trauma cases from January 2016 to December 2020, in which patients hospitalized and treated under the trauma unit were included. The collected data included several variables (e.g., demographics, mechanism of injury), and the patients were divided into early/late phase and severe/non-severe cases.</p><p><strong>Results: </strong>In total, there were 2024 cases, 70% were polytraumas with a mean age of 29 years and a male-to-female ratio of 3.8:1. The most common mechanism of injury was motor vehicle collision (55%) while the most common injuries were pneumothorax (18%) and lung contusions (17%). Notably, there was a 3.5-hour reduction in both the time to the operating room and the time to normotension when comparing the early to late phase. The 30-day outcomes for the patients were 90.5% recovery, 2.2% disability, 2.2% transfer, and 5.1% mortality rates.</p><p><strong>Conclusion: </strong>This study emphasizes how crucial trauma quality indicators are to achieve the best outcomes for patients. The results point to improvements in terms of trauma quality indicators and offer insightful information on patterns of traumatic injuries, aiding in the enhancement of trauma care. Thus, the continuous assessment of trauma quality indicators and the implementation of preventive measures are mandatory for the future advancement of trauma care.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 3","pages":"226-231"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thirty Years of Editorial Experience of the Oldest Bosnia and Herzegovina Medical Journal \"Medicinski Arhiv/Medical Archives\".","authors":"Izet Masic","doi":"10.5455/medarh.2024.78.266-273","DOIUrl":"10.5455/medarh.2024.78.266-273","url":null,"abstract":"","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 4","pages":"266-273"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of Tranexamic Acid in Case of Patient with Intracerebral Hemorrhage After a Coronary Procedure-Case Report.","authors":"Amra Salkic, Amel Amidzic, Stoja Eric, Nermina Gorana-Polimac, Naida Tiro, Merita Tiric-Campara","doi":"10.5455/medarh.2024.78.317-321","DOIUrl":"10.5455/medarh.2024.78.317-321","url":null,"abstract":"<p><strong>Background: </strong>Tranexamic acid can prevent death from bleeding after trauma and postpartum hemorrhage.</p><p><strong>Objective: </strong>The aim of the paper was to assess whether tranexamic acid reduces hematoma expansion and improves outcome in adults with stroke caused by intracerebral hemorrhage.</p><p><strong>Case presentation: </strong>Administration of Tranexamic acid in a patient after a diagnosis of intracerebral hematoma, which occurred after coronary stent implantation. Intracerebral hematoma, or neurological deficit, occurs one day after cardiac surgery in the patient. The case report will present the radiological resolution of the intracerebral hematoma, as well as the improvement of the clinical picture, neurological deficit, in the patient during a one-month follow-up, after the administration of Tranexamic acid.</p><p><strong>Conclusion: </strong>Tranexemic acid is affordable, easy to administer, appears to be safe, and is widely available, so even a modest treatment effect can have an important global impact, and it is necessary to consider its more frequent use, as well as to initiate larger randomized trials.</p>","PeriodicalId":94135,"journal":{"name":"Medical archives (Sarajevo, Bosnia and Herzegovina)","volume":"78 4","pages":"317-321"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}