IF 10.7

MedComm Pub Date : 2024-07-15 DOI: 10.1002/mco2.637

Xiaolong Ya, Chenglong Liu, Long Ma, Peicong Ge, Xiaoxue Xu, Zhiyao Zheng, Siqi Mou, Rong Wang, Qian Zhang, Xun Ye, Dong Zhang, Yan Zhang, Wenjing Wang, Hao Li, Jizong Zhao

{"title":"Single-cell atlas of peripheral blood by CyTOF revealed peripheral blood immune cells metabolic alterations and neutrophil changes in intracranial aneurysm rupture","authors":"Xiaolong Ya, Chenglong Liu, Long Ma, Peicong Ge, Xiaoxue Xu, Zhiyao Zheng, Siqi Mou, Rong Wang, Qian Zhang, Xun Ye, Dong Zhang, Yan Zhang, Wenjing Wang, Hao Li, Jizong Zhao","doi":"10.1002/mco2.637","DOIUrl":"https://doi.org/10.1002/mco2.637","url":null,"abstract":"Previous studies have found that the peripheral immune environment is closely related to the occurrence and development of intracranial aneurysms. However, it remains unclear how the metabolism of peripheral blood mononuclear cells (PBMCs) and the composition of polymorphonuclear leukocytes (PMNs) changes in the process of intracranial aneurysm rupture. This study utilized cytometry by time of flight technology to conduct single-cell profiling analysis of PBMCs and PMNs from 72 patients with IAs. By comparing the expression differences of key metabolic enzymes in PBMCs between patients with ruptured intracranial aneurysms (RIAs) and unruptured intracranial aneurysms, we found that most PBMCs subsets from RIA group showed upregulation of rate-limiting enzymes related to the glycolytic pathway. By comparing the composition of PMNs, it was found that the proinflammatory CD101+HLA DR+ subsets were increased in the RIA group, accompanied by a decrease in the anti-inflammatory polymorphonuclear myeloid-derived suppressor cells. In conclusion, this study showed the changes in the peripheral immune profile of RIAs, which is helpful for our understanding of the mechanisms underlying peripheral changes and provides a direction for future related research.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141624510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases 外泌体纳米微粒：治疗人类疾病的生物标记物和新策略

IF 10.7

MedComm Pub Date : 2024-07-15 DOI: 10.1002/mco2.660

Chuan Xu, Chaoyang Jiang, Zhihui Li, Hui Gao, Jing Xian, Wenyan Guo, Dan He, Xingchen Peng, Daijun Zhou, Dong Li

{"title":"Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases","authors":"Chuan Xu, Chaoyang Jiang, Zhihui Li, Hui Gao, Jing Xian, Wenyan Guo, Dan He, Xingchen Peng, Daijun Zhou, Dong Li","doi":"10.1002/mco2.660","DOIUrl":"https://doi.org/10.1002/mco2.660","url":null,"abstract":"Exosomes are nanoscale vesicles of cellular origin. One of the main characteristics of exosomes is their ability to carry a wide range of biomolecules from their parental cells, which are important mediators of intercellular communication and play an important role in physiological and pathological processes. Exosomes have the advantages of biocompatibility, low immunogenicity, and wide biodistribution. As researchers’ understanding of exosomes has increased, various strategies have been proposed for their use in diagnosing and treating diseases. Here, we provide an overview of the biogenesis and composition of exosomes, describe the relationship between exosomes and disease progression, and focus on the use of exosomes as biomarkers for early screening, disease monitoring, and guiding therapy in refractory diseases such as tumors and neurodegenerative diseases. We also summarize the current applications of exosomes, especially engineered exosomes, for efficient drug delivery, targeted therapies, gene therapies, and immune vaccines. Finally, the current challenges and potential research directions for the clinical application of exosomes are also discussed. In conclusion, exosomes, as an emerging molecule that can be used in the diagnosis and treatment of diseases, combined with multidisciplinary innovative solutions, will play an important role in clinical applications.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.660","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141624511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNMT3A dysfunction promotes neuroinflammation and exacerbates acute ischemic stroke DNMT3A 功能障碍会促进神经炎症并加剧急性缺血性中风。

IF 10.7

MedComm Pub Date : 2024-07-14 DOI: 10.1002/mco2.652

Tian-Jie Lyu, Xin Qiu, Yubo Wang, Ling Zhang, Yalun Dai, Xuechun Wang, Shunying Zhao, Meilin Xiang, Lu Cui, Si Cheng, Yang Liu, Hongqiu Gu, Yong Jiang, Xia Meng, Yilong Wang, Xingquan Zhao, Xianwei Wang, Qian Li, Meng Wang, Yingyu Jiang, Zhe Xu, Xinying Huang, Hao Li, Yongjun Wang, Zixiao Li

{"title":"DNMT3A dysfunction promotes neuroinflammation and exacerbates acute ischemic stroke","authors":"Tian-Jie Lyu, Xin Qiu, Yubo Wang, Ling Zhang, Yalun Dai, Xuechun Wang, Shunying Zhao, Meilin Xiang, Lu Cui, Si Cheng, Yang Liu, Hongqiu Gu, Yong Jiang, Xia Meng, Yilong Wang, Xingquan Zhao, Xianwei Wang, Qian Li, Meng Wang, Yingyu Jiang, Zhe Xu, Xinying Huang, Hao Li, Yongjun Wang, Zixiao Li","doi":"10.1002/mco2.652","DOIUrl":"10.1002/mco2.652","url":null,"abstract":"Somatic mutations related to clonal hematopoiesis of indeterminate potential (CHIP) are risk factors for stroke. The impact of DNMT3A, the most mutated gene in CHIP, on clinical functional outcomes of acute ischemic stroke (AIS) remains unclear. In a well-characterized cohort of 8524 ischemic stroke patients, we demonstrated that DNMT3A-driven CHIP was significantly associated with neurological disability in these patients. With a stroke mouse model of transient middle cerebral artery occlusion (tMCAO), we demonstrated that DNMT3A protein levels in the brain penumbra increased. The DNMT3A inhibitor RG108 administration amplified neutrophil proliferation in the blood, promoted neutrophil infiltration into the brain penumbra, and exaggerated proinflammatory activation in tMCAO male mice. DNMT3A inhibition also significantly increased infarct volume and worsened neurobehavioral function in tMCAO male mice. In conclusion, DNMT3A somatic mutations are associated with worsened neurological disability in some patients with AIS, potentially through increased neutrophil proliferation and infiltration in the ischemic brain region. These findings suggest a possible mechanism for proinflammatory activation and tissue damage in the affected brain tissue, highlighting the need for further research in this area.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of pulmonary embolism and deep vein thrombosis following COVID-19: a nationwide cohort study COVID-19 后发生肺栓塞和深静脉血栓的风险：一项全国性队列研究。

IF 10.7

MedComm Pub Date : 2024-07-14 DOI: 10.1002/mco2.655

Hye Jun Kim, Seogsong Jeong, Jihun Song, Sun Jae Park, Young Jun Park, Yun Hwan Oh, Jaehun Jung, Sang Min Park

{"title":"Risk of pulmonary embolism and deep vein thrombosis following COVID-19: a nationwide cohort study","authors":"Hye Jun Kim, Seogsong Jeong, Jihun Song, Sun Jae Park, Young Jun Park, Yun Hwan Oh, Jaehun Jung, Sang Min Park","doi":"10.1002/mco2.655","DOIUrl":"10.1002/mco2.655","url":null,"abstract":"Recent studies elucidate that coronavirus disease 2019 (COVID-19) patients may face a higher risk of cardiovascular complications. This study aimed to evaluate association of COVID-19 with the risk of pulmonary embolism (PE) or deep vein thrombosis (DVT). This nationwide population-based retrospective cohort study included Korean adult citizens between January 2021 and March 2022 from the Korea Disease Control and Prevention Agency COVID-19 National Health Insurance Service cohort. The Fine and Gray's regression with all-cause death as a competing event was adopted to evaluate PE and DVT risks after COVID-19. This study included a total of 1,601,835 COVID-19 patients and 14,011,285 matched individuals without COVID-19. The risk of PE (adjusted hazard ratio [aHR], 6.25; 95% confidence interval [CI], 3.67–10.66; p < 0.001) and DVT (aHR, 3.05; 95% CI, 1.75–5.29; p < 0.001) was higher in COVID-19 group in individuals without complete COVID-19 vaccination. In addition, individuals with complete COVID-19 vaccination still had a higher risk of COVID-19-related PE (aHR, 1.48; 95% CI, 1.15–1.88; p < 0.001). However, COVID-19 was not a significant risk factor for DVT among those with complete COVID-19 vaccination. COVID-19 was identified as an independent factor that elevated PE and DVT risks, especially for individuals without complete COVID-19 vaccination.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid–liquid phase separation in diseases 疾病中的液-液相分离

IF 10.7

MedComm Pub Date : 2024-07-13 DOI: 10.1002/mco2.640

Xinyue Zhang, Lin Yuan, Wanlu Zhang, Yi Zhang, Qun Wu, Chunting Li, Min Wu, Yongye Huang

{"title":"Liquid–liquid phase separation in diseases","authors":"Xinyue Zhang, Lin Yuan, Wanlu Zhang, Yi Zhang, Qun Wu, Chunting Li, Min Wu, Yongye Huang","doi":"10.1002/mco2.640","DOIUrl":"https://doi.org/10.1002/mco2.640","url":null,"abstract":"Liquid–liquid phase separation (LLPS), an emerging biophysical phenomenon, can sequester molecules to implement physiological and pathological functions. LLPS implements the assembly of numerous membraneless chambers, including stress granules and P-bodies, containing RNA and protein. RNA–RNA and RNA–protein interactions play a critical role in LLPS. Scaffolding proteins, through multivalent interactions and external factors, support protein–RNA interaction networks to form condensates involved in a variety of diseases, particularly neurodegenerative diseases and cancer. Modulating LLPS phenomenon in multiple pathogenic proteins for the treatment of neurodegenerative diseases and cancer could present a promising direction, though recent advances in this area are limited. Here, we summarize in detail the complexity of LLPS in constructing signaling pathways and highlight the role of LLPS in neurodegenerative diseases and cancers. We also explore RNA modifications on LLPS to alter diseases progression because these modifications can influence LLPS of certain proteins or the formation of stress granules, and discuss the possibility of proper manipulation of LLPS process to restore cellular homeostasis or develop therapeutic drugs for the eradication of diseases. This review attempts to discuss potential therapeutic opportunities by elaborating on the connection between LLPS, RNA modification, and their roles in diseases.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.640","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141608085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier 阿尔茨海默病和其他神经退行性疾病中的小脑：一个新兴的研究领域

IF 10.7

MedComm Pub Date : 2024-07-13 DOI: 10.1002/mco2.638

Cui Yang, Guangdong Liu, Xi Chen, Weidong Le

{"title":"Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier","authors":"Cui Yang, Guangdong Liu, Xi Chen, Weidong Le","doi":"10.1002/mco2.638","DOIUrl":"https://doi.org/10.1002/mco2.638","url":null,"abstract":"The cerebellum is crucial for both motor and nonmotor functions. Alzheimer's disease (AD), alongside other dementias such as vascular dementia (VaD), Lewy body dementia (DLB), and frontotemporal dementia (FTD), as well as other neurodegenerative diseases (NDs) like Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and spinocerebellar ataxias (SCA), are characterized by specific and non-specific neurodegenerations in central nervous system. Previously, the cerebellum's significance in these conditions was underestimated. However, advancing research has elevated its profile as a critical node in disease pathology. We comprehensively review the existing evidence to elucidate the relationship between cerebellum and the aforementioned diseases. Our findings reveal a growing body of research unequivocally establishing a link between the cerebellum and AD, other forms of dementia, and other NDs, supported by clinical evidence, pathological and biochemical profiles, structural and functional neuroimaging data, and electrophysiological findings. By contrasting cerebellar observations with those from the cerebral cortex and hippocampus, we highlight the cerebellum's distinct role in the disease processes. Furthermore, we also explore the emerging therapeutic potential of targeting cerebellum for the treatment of these diseases. This review underscores the importance of the cerebellum in these diseases, offering new insights into the disease mechanisms and novel therapeutic strategies.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.638","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141608084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of an alternative ligand-binding pocket in peroxisome proliferator-activated receptor gamma and its correlated selective agonist for promoting beige adipocyte differentiation 鉴定过氧化物酶体增殖激活受体γ的替代配体结合袋及其相关的选择性激动剂，以促进米色脂肪细胞分化。

IF 10.7

MedComm Pub Date : 2024-07-10 DOI: 10.1002/mco2.650

Qiang Tian, Miaohua Wang, Xueting Wang, Zhenli Lei, Owais Ahmad, Dianhua Chen, Wei Zheng, Pingping Shen, Nanfei Yang

{"title":"Identification of an alternative ligand-binding pocket in peroxisome proliferator-activated receptor gamma and its correlated selective agonist for promoting beige adipocyte differentiation","authors":"Qiang Tian, Miaohua Wang, Xueting Wang, Zhenli Lei, Owais Ahmad, Dianhua Chen, Wei Zheng, Pingping Shen, Nanfei Yang","doi":"10.1002/mco2.650","DOIUrl":"10.1002/mco2.650","url":null,"abstract":"The pharmacological activation of peroxisome proliferator-activated receptor gamma (PPARγ) is a convenient and promising strategy for promoting beige adipocyte biogenesis to combat obesity-related metabolic disorders. However, thiazolidinediones (TZDs), the full agonists of PPARγ exhibit severe side effects in animal models and in clinical settings. Therefore, the development of efficient and safe PPARγ modulators for the treatment of metabolic diseases is emerging. In this study, using comprehensive methods, we report a previously unidentified ligand-binding pocket (LBP) in PPARγ and link it to beige adipocyte differentiation. Further virtual screening of 4097 natural compounds based on this novel LBP revealed that saikosaponin A (NJT-2), a terpenoid compound, can bind to PPARγ to induce coactivator recruitment and effectively activate PPARγ-mediated transcription of the beige adipocyte program. In a mouse model, NJT-2 administration efficiently promoted beige adipocyte biogenesis and improved obesity-associated metabolic dysfunction, with significantly fewer adverse effects than those observed with TZD. Our results not only provide an advanced molecular insight into the structural ligand-binding details in PPARγ, but also develop a linked selective and safe agonist for obesity treatment.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11233932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ischemia-enhanced myocardial infarction protection-related lncRNA protects against acute myocardial infarction 缺血增强型心肌梗死保护相关lncRNA可预防急性心肌梗死。

IF 10.7

MedComm Pub Date : 2024-07-10 DOI: 10.1002/mco2.632

Rongzhou Wu, Tingting Wu, Qiaoyu Wang, Youyang Shi, Qianqian Dong, Xing Rong, Meiting Chen, Zhiyu He, Yu Fu, Lei Liu, Shuai Shao, Xueqiang Guan, Chunxiang Zhang

{"title":"The ischemia-enhanced myocardial infarction protection-related lncRNA protects against acute myocardial infarction","authors":"Rongzhou Wu, Tingting Wu, Qiaoyu Wang, Youyang Shi, Qianqian Dong, Xing Rong, Meiting Chen, Zhiyu He, Yu Fu, Lei Liu, Shuai Shao, Xueqiang Guan, Chunxiang Zhang","doi":"10.1002/mco2.632","DOIUrl":"10.1002/mco2.632","url":null,"abstract":"Long non-coding RNA RP11-64B16.4 (myocardial infarction protection-related lncRNA [MIPRL]) is among the most abundant and the most upregulated lncRNAs in ischemic human hearts. However, its role in ischemic heart disease is unknown. We found MIPRL was conserved between human and mouse and its expression was increased in mouse hearts after acute myocardial infarction (AMI) and in cultured human and mouse cardiomyocytes after hypoxia. The infarcted size, cardiac cell apoptosis, cardiac dysfunction, and cardiac fibrosis were aggravated in MIPRL knockout mice after AMI. The above adverse results could be reversed by re-expression of MIPRL via adenovirus expressing MIPRL. Both in vitro and in vivo, we identified that heat shock protein beta-8 (HSPB8) was a target gene of MIPRL, which was involved in MIPRL-mediated anti-apoptotic effects on cardiomyocytes. We further discovered that MIPRL could combine with the messenger RNA (mRNA) of HSPB8 and increase its expression in cardiomyocytes by enhancing the stability of HSPB8 mRNA. In summary, we have found for the first time that the ischemia-enhanced lncRNA MIPRL protects against AMI via its target gene HSPB8. MIPRL might be a novel promising therapeutic target for ischemic heart diseases such as AMI.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling dynamic immunological landscapes in intracerebral hemorrhage: insights from single-cell and spatial transcriptomic profiling 揭示脑出血的动态免疫景观：单细胞和空间转录组特征分析的启示。

IF 10.7

MedComm Pub Date : 2024-07-10 DOI: 10.1002/mco2.635

Lingui Gu, Hualin Chen, Mingjiang Sun, Yihao Chen, Qinglei Shi, Jianbo Chang, Junji Wei, Wenbin Ma, Xinjie Bao, Renzhi Wang

{"title":"Unraveling dynamic immunological landscapes in intracerebral hemorrhage: insights from single-cell and spatial transcriptomic profiling","authors":"Lingui Gu, Hualin Chen, Mingjiang Sun, Yihao Chen, Qinglei Shi, Jianbo Chang, Junji Wei, Wenbin Ma, Xinjie Bao, Renzhi Wang","doi":"10.1002/mco2.635","DOIUrl":"10.1002/mco2.635","url":null,"abstract":"Intracerebral hemorrhage (ICH) poses a formidable challenge in stroke management, with limited therapeutic options, particularly in the realm of immune-targeted interventions. Clinical trials targeting immune responses post-ICH have encountered setbacks, potentially attributable to the substantial cellular heterogeneity and intricate intercellular networks within the brain. Here, we present a pioneering investigation utilizing single-cell RNA sequencing and spatial transcriptome profiling at hyperacute (1 h), acute (24 h), and subacute (7 days) intervals post-ICH, aimed at unraveling the dynamic immunological landscape and spatial distributions within the cerebral tissue. Our comprehensive analysis revealed distinct cell differentiation patterns among myeloid and lymphocyte populations, along with delineated spatial distributions across various brain regions. Notably, we identified a subset of lymphocytes characterized by the expression of Spp1 and Lyz2, termed macrophage-associated lymphocytes, which exhibited close interactions with myeloid cells. Specifically, we observed prominent interactions between Lgmn+Macro-T cells and microglia through the spp1–cd44 pathway during the acute phase post-ICH in the choroid plexus. These findings represent a significant advancement in our understanding of immune cell dynamics at single-cell resolution across distinct post-ICH time points, thereby laying the groundwork for exploring critical temporal windows and informing the development of targeted therapeutic strategies.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11233862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromothripsis is a novel biomarker for prognosis and differentiation diagnosis of pancreatic neuroendocrine neoplasms Chromothripsis 是用于胰腺神经内分泌肿瘤预后和分化诊断的新型生物标记物。

IF 10.7

MedComm Pub Date : 2024-07-10 DOI: 10.1002/mco2.623

Ming-Yi Zhang, Du He, Yi Zhang, Ke Cheng, Hong-Shuai Li, Yu-Wen Zhou, Qiong-Xian Long, Rui-Zhi Liu, Ji-Yan Liu

{"title":"Chromothripsis is a novel biomarker for prognosis and differentiation diagnosis of pancreatic neuroendocrine neoplasms","authors":"Ming-Yi Zhang, Du He, Yi Zhang, Ke Cheng, Hong-Shuai Li, Yu-Wen Zhou, Qiong-Xian Long, Rui-Zhi Liu, Ji-Yan Liu","doi":"10.1002/mco2.623","DOIUrl":"10.1002/mco2.623","url":null,"abstract":"This study aimed to identify the role of chromothripsis as a novel biomarker in the prognosis and differentiation diagnosis of pancreatic neuroendocrine neoplasms (pNENs). We conducted next-generation gene sequencing in a cohort of 30 patients with high-grade (G3) pNENs. As a reference, a similar analysis was also performed on 25 patients with low-grade (G1/G2) pancreatic neuroendocrine tumors (pNETs). Chromothripsis and its relationship with clinicopathological features and prognosis were investigated. The results showed that DNA damage response and repair gene alteration and TP53 mutation were found in 29 and 11 patients, respectively. A total of 14 out of 55 patients had chromothripsis involving different chromosomes. Chromothripsis had a close relationship with TP53 alteration and higher grade. In the entire cohort, chromothripsis was associated with a higher risk of distant metastasis; both chromothripsis and metastasis (ENETS Stage IV) suggested a significantly shorter overall survival (OS). Importantly, in the high-grade pNENs group, chromothripsis was the only independent prognostic indicator significantly associated with a shorter OS, other than TP53 alteration or pathological pancreatic neuroendocrine carcinomas (pNECs) diagnosis. Chromothripsis can guide worse prognosis in pNENs, and help differentiate pNECs from high-grade (G3) pNETs.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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