MedComm最新文献 - Book学术

Immunometabolism: signaling pathways, homeostasis, and therapeutic targets 免疫代谢：信号通路、稳态和治疗目标

IF 10.7

MedComm Pub Date : 2024-11-03 DOI: 10.1002/mco2.789

Rongrong Xu, Xiaobo He, Jia Xu, Ganjun Yu, Yanfeng Wu

{"title":"Immunometabolism: signaling pathways, homeostasis, and therapeutic targets","authors":"Rongrong Xu, Xiaobo He, Jia Xu, Ganjun Yu, Yanfeng Wu","doi":"10.1002/mco2.789","DOIUrl":"https://doi.org/10.1002/mco2.789","url":null,"abstract":"Immunometabolism plays a central role in sustaining immune system functionality and preserving physiological homeostasis within the organism. During the differentiation and activation, immune cells undergo metabolic reprogramming mediated by complex signaling pathways. Immune cells maintain homeostasis and are influenced by metabolic microenvironmental cues. A series of immunometabolic enzymes modulate immune cell function by metabolizing nutrients and accumulating metabolic products. These enzymes reverse immune cells’ differentiation, disrupt intracellular signaling pathways, and regulate immune responses, thereby influencing disease progression. The huge population of immune metabolic enzymes, the ubiquity, and the complexity of metabolic regulation have kept the immune metabolic mechanisms related to many diseases from being discovered, and what has been revealed so far is only the tip of the iceberg. This review comprehensively summarized the immune metabolic enzymes’ role in multiple immune cells such as T cells, macrophages, natural killer cells, and dendritic cells. By classifying and dissecting the immunometabolism mechanisms and the implications in diseases, summarizing and analyzing advancements in research and clinical applications of the inhibitors targeting these enzymes, this review is intended to provide a new perspective concerning immune metabolic enzymes for understanding the immune system, and offer novel insight into future therapeutic interventions.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.789","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An inflammatory cytokine signature predicts IgA nephropathy severity and progression 炎症细胞因子特征可预测 IgA 肾病的严重程度和病情发展

IF 10.7

MedComm Pub Date : 2024-11-03 DOI: 10.1002/mco2.783

Lei Chen, Xizhao Chen, Guangyan Cai, Hongli Jiang, Xiangmei Chen, Min Zhang

{"title":"An inflammatory cytokine signature predicts IgA nephropathy severity and progression","authors":"Lei Chen, Xizhao Chen, Guangyan Cai, Hongli Jiang, Xiangmei Chen, Min Zhang","doi":"10.1002/mco2.783","DOIUrl":"https://doi.org/10.1002/mco2.783","url":null,"abstract":"IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis, resulting in end-stage renal disease and increased mortality rates. Prognostic biomarkers reflecting molecular mechanisms for effective IgAN management are urgently needed. Analysis of kidney single-cell transcriptomic sequencing data demonstrated that IgAN expressed high-expression levels of inflammatory cytokines TNFSF10, TNFSF12, CCL2, CXCL1, and CXCL12 than healthy controls (HCs). We also measured the urine proteins in 120 IgAN (57 stable and 63 progressive) and 32 HCs using the proximity extension assay (PEA), and the multivariable and least absolute shrinkage and selection operator (LASSO) logistic regression analysis both revealed that CXCL12, MCP1 were the prognostic significant variables to predict IgAN progression severity. These two proteins exhibited negative correlation with the estimated glomerular filtration rate (eGFR) and patients with higher expression levels of these two proteins had a higher probability to have poorer renal outcome. We further developed a risk index model utilizing CXCL12, MCP1, and baseline clinical indicators, which achieved an impressive area under the curve (AUC) of 0.896 for prediction of IgAN progression severity. Our study highlights the significance of the inflammatory protein biomarkers for noninvasive prediction of IgAN severity and progression, offering valuable insights for clinical management.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.783","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell transcriptomics reveals IRF7 regulation of the tumor microenvironment in isocitrate dehydrogenase wild-type glioma 单细胞转录组学揭示了IRF7对异柠檬酸脱氢酶野生型胶质瘤肿瘤微环境的调控作用

IF 10.7

MedComm Pub Date : 2024-11-03 DOI: 10.1002/mco2.754

Jinwei Li, Shengrong Long, Zhang Yang, Wei Wei, Shuangqi Yu, Quan Liu, Xuhui Hui, Xiang Li, Yinyan Wang

{"title":"Single-cell transcriptomics reveals IRF7 regulation of the tumor microenvironment in isocitrate dehydrogenase wild-type glioma","authors":"Jinwei Li, Shengrong Long, Zhang Yang, Wei Wei, Shuangqi Yu, Quan Liu, Xuhui Hui, Xiang Li, Yinyan Wang","doi":"10.1002/mco2.754","DOIUrl":"https://doi.org/10.1002/mco2.754","url":null,"abstract":"Mutations in isocitrate dehydrogenase (IDH) are important markers of glioma prognosis. However, few studies have examined the gene expression regulatory network (GRN) in IDH-mutant and wild-type gliomas. In this study, single-cell RNA sequencing and spatial transcriptome sequencing were used to analyze the GRN of cell subsets in patients with IDH-mutant and wild-type gliomas. Through gene transcriptional regulation analysis, we identified the M4 module, whose transcription factor activity is highly expressed in IDH wild-type gliomas compared to IDH-mutants. Enrichment analysis revealed that these genes were predominantly expressed in microglia and macrophages, with significant enrichment in interferon-related signaling pathways. Interferon regulatory factor 7 (IRF7), a transcription factor within this pathway, showed the highest percentage of enrichment and was primarily localized in the core region of wild-type IDH tumors. A machine-learning prognostic model identified novel subgroups within the wild-type IDH population. Additionally, IRF7 was shown to promote the proliferation and migration of T98G and U251 cells in vitro, and its knockdown affected glioma cell proliferation in vivo. This study systematically established the regulatory mechanism of IDH transcriptional activity in gliomas at the single-cell level and drew a corresponding cell map. The study presents a transcriptional regulatory activity map for IDH wild-type gliomas, involving single-cell RNA sequencing and spatial transcriptomics to identify gene regulatory networks, machine learning models for IDH subtyping, and experimental validation, highlighting the role of IRF7 in glioma progression.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.754","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic impact of age on outcomes of hepatic decompensation in patients with compensated cirrhosis (CHESS2102): an international, multicenter cohort study 年龄对代偿期肝硬化患者肝功能失代偿预后的影响（CHESS2102）：一项国际多中心队列研究

IF 10.7

MedComm Pub Date : 2024-11-03 DOI: 10.1002/mco2.781

Shanghao Liu, Jia Li, Yujun Wong, Hyung Joon Yim, Masashi Hirooka, Hirayuki Enomoto, Qing Xie, Erhei Dai, Amr Shaaban Hanafy, Zhujun Cao, Lili Zhao, Kok Ban Teh, Tae Hyung Kim, Young Kul Jung, Yohei Koizumi, Yoichi Hiasa, Takashi Nishimura, Hiroko Iijima, Qingyi Tian, Xinru Guo, Yansheng Jia, Jinfang Sun, Chuan Liu, Xiaolong Qi

{"title":"Prognostic impact of age on outcomes of hepatic decompensation in patients with compensated cirrhosis (CHESS2102): an international, multicenter cohort study","authors":"Shanghao Liu, Jia Li, Yujun Wong, Hyung Joon Yim, Masashi Hirooka, Hirayuki Enomoto, Qing Xie, Erhei Dai, Amr Shaaban Hanafy, Zhujun Cao, Lili Zhao, Kok Ban Teh, Tae Hyung Kim, Young Kul Jung, Yohei Koizumi, Yoichi Hiasa, Takashi Nishimura, Hiroko Iijima, Qingyi Tian, Xinru Guo, Yansheng Jia, Jinfang Sun, Chuan Liu, Xiaolong Qi","doi":"10.1002/mco2.781","DOIUrl":"https://doi.org/10.1002/mco2.781","url":null,"abstract":"Baveno VII criteria (B7C) and Baveno VI criteria (B6C) have been widely used to estimate the risk of hepatic decompensation. However, the impact of age on these criteria warrants further investigation. The international, multicenter cohort study included 1138 patients with compensated cirrhosis (median follow-up of 40.6 months), aiming to evaluate the value of age in predicting hepatic decompensation. We identified age as an independent predictor of hepatic decompensation, with 60 years determined as the optimal cut-off value. The occurrence of decompensation was 18.7% and 6.7% in the older (age ≥60 years) and younger (age <60 years) groups, respectively (p < 0.001). We subsequently integrated age into the existing Baveno criteria. In patients not meeting Baveno criteria (defined as not meeting B6C or B7C), the older group exhibited a significantly elevated risk of decompensation compared to the younger group (p < 0.05). However, no significant difference was observed between the older and younger groups in patients meeting Baveno criteria (p > 0.05). In conclusion, our study demonstrated that integrating age into the Baveno criteria could enhance the assessment of hepatic decompensation. Age should be considered before discharging patients with compensated cirrhosis from the surveillance of hepatic decompensation.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.781","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Raman spectroscopy on dried blood plasma allows diagnosis and monitoring of colorectal cancer 干血浆拉曼光谱可诊断和监测结直肠癌

IF 10.7

MedComm Pub Date : 2024-10-31 DOI: 10.1002/mco2.774

Carlo Morasso, Elena Daveri, Arianna Bonizzi, Marta Truffi, Francesco Colombo, Piergiorgio Danelli, Sara Albasini, Licia Rivoltini, Serena Mazzucchelli, Luca Sorrentino, Fabio Corsi

{"title":"Raman spectroscopy on dried blood plasma allows diagnosis and monitoring of colorectal cancer","authors":"Carlo Morasso, Elena Daveri, Arianna Bonizzi, Marta Truffi, Francesco Colombo, Piergiorgio Danelli, Sara Albasini, Licia Rivoltini, Serena Mazzucchelli, Luca Sorrentino, Fabio Corsi","doi":"10.1002/mco2.774","DOIUrl":"https://doi.org/10.1002/mco2.774","url":null,"abstract":"Colorectal cancer (CRC) remains challenging to diagnose, necessitating the identification of a noninvasive biomarker that can differentiate it from other conditions such as inflammatory bowel diseases (IBD) and diverticular disease (DD). Raman spectroscopy (RS) stands out as a promising technique for monitoring blood biochemical profiles, with the potential to identify distinct signatures identifying CRC subjects. We performed RS analysis on dried plasma from 120 subjects: 32 CRC patients, 37 IBD patients, 20 DD patients, and 31 healthy controls. We also conducted longitudinal studies of CRC patient's postsurgery to monitor the spectral changes over time. We identified six spectral features that showed significant differences between CRC and non-CRC patients, corresponding to tryptophan, tyrosine, phenylalanine, lipids, carotenoids, and disulfide bridges. These features enabled the classification of CRC patients with an accuracy of 87.5%. Moreover, longitudinal analysis revealed that the spectral differences normalized over 6 months after surgery, indicating their association with the presence of the disease. Our study demonstrates the potential of RS to identify specific biomolecular signatures related to CRC. These results suggest that RS could be a novel screening and monitoring tool, providing valuable insights for the development of noninvasive and accurate diagnostic methods for CRC.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.774","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disorganized thalamic subregional functional connectivity in bipolar I disorder 双相情感障碍 I 中丘脑次区域功能连接紊乱

IF 10.7

MedComm Pub Date : 2024-10-31 DOI: 10.1002/mco2.771

Xipeng Long, Xiuli Wang, Yuan Cao, Di Kong, Baolin Wu, Hongsheng Xie, Ziru Zhao, Neil Roberts, Qiyong Gong, Zhiyun Jia

{"title":"Disorganized thalamic subregional functional connectivity in bipolar I disorder","authors":"Xipeng Long, Xiuli Wang, Yuan Cao, Di Kong, Baolin Wu, Hongsheng Xie, Ziru Zhao, Neil Roberts, Qiyong Gong, Zhiyun Jia","doi":"10.1002/mco2.771","DOIUrl":"https://doi.org/10.1002/mco2.771","url":null,"abstract":"Thalamus plays a pivotal role in the pathophysiology of neuropsychiatric conditions due to its strategic position and intricate connectivity with the cerebral cortex, limbic system, and other subcortical structures. In the present study, the potential involvement of the thalamus and subregions of the thalamus are explored in bipolar disorder (BD). In particular, functional and structural magnetic resonance imaging was performed on 73 adult patients with BD-I and 78 healthy controls (HCs). Seed-based thalamus and thalamic subregional functional connectivity (FC) were compared between the BD-I patients and HCs. Compared to HCs, patients with BD-I showed higher FC between the left thalamus and right lingual gyrus and altered FC between the dorsal thalamus and the default mode network and prefrontal regions, which may be correlated with mania symptomatology. In patients with BD-I, the anterior subregions of the thalamus had higher FC than the posterior subregions. No significant difference in gray matter volume or local functional activity was found in the thalamus and thalamic subregions between BD-I and HC. These findings provide evidence of disorganized thalamocortical FC in BD-I, suggesting that the thalamus and its subregions may play important and specific roles in the neural circuitry of BD.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.771","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the DNA damage response in cancer 瞄准癌症中的 DNA 损伤反应

IF 10.7

MedComm Pub Date : 2024-10-31 DOI: 10.1002/mco2.788

Guffanti Federica, Chiappa Michela, Damia Giovanna

{"title":"Targeting the DNA damage response in cancer","authors":"Guffanti Federica, Chiappa Michela, Damia Giovanna","doi":"10.1002/mco2.788","DOIUrl":"https://doi.org/10.1002/mco2.788","url":null,"abstract":"DNA damage response (DDR) pathway is the coordinated cellular network dealing with the identification, signaling, and repair of DNA damage. It tightly regulates cell cycle progression and promotes DNA repair to minimize DNA damage to daughter cells. Key proteins involved in DDR are frequently mutated/inactivated in human cancers and promote genomic instability, a recognized hallmark of cancer. Besides being an intrinsic property of tumors, DDR also represents a unique therapeutic opportunity. Indeed, inhibition of DDR is expected to delay repair, causing persistent unrepaired breaks, to interfere with cell cycle progression, and to sensitize cancer cells to several DNA-damaging agents, such as radiotherapy and chemotherapy. In addition, DDR defects in cancer cells have been shown to render these cells more dependent on the remaining pathways, which could be targeted very specifically (synthetic lethal approach). Research over the past two decades has led to the synthesis and testing of hundreds of small inhibitors against key DDR proteins, some of which have shown antitumor activity in human cancers. In parallel, the search for synthetic lethality interaction is broadening the use of DDR inhibitors. In this review, we discuss the state-of-art of ataxia-telangiectasia mutated, ataxia-telangiectasia-and-Rad3-related protein, checkpoint kinase 1, Wee1 and Polθ inhibitors, highlighting the results obtained in the ongoing clinical trials both in monotherapy and in combination with chemotherapy and radiotherapy.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.788","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic role of lipoprotein(a) in atherosclerotic cardiovascular disease risk from a perspective on current risk stratification 从当前风险分层的角度看脂蛋白（a）在动脉粥样硬化性心血管疾病风险中的预后作用

IF 10.7

MedComm Pub Date : 2024-10-31 DOI: 10.1002/mco2.773

Sha Li, Hui-Hui Liu, Yan Zhang, Meng Zhang, Hui-Wen Zhang, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong, Jie Qian, Ke-Fei Dou, Yuan-Lin Guo, Jian-Jun Li

{"title":"Prognostic role of lipoprotein(a) in atherosclerotic cardiovascular disease risk from a perspective on current risk stratification","authors":"Sha Li, Hui-Hui Liu, Yan Zhang, Meng Zhang, Hui-Wen Zhang, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong, Jie Qian, Ke-Fei Dou, Yuan-Lin Guo, Jian-Jun Li","doi":"10.1002/mco2.773","DOIUrl":"https://doi.org/10.1002/mco2.773","url":null,"abstract":"Lipoprotein(a) [Lp(a)] is an emerging predictor for atherosclerotic cardiovascular disease (ASCVD) but the association from a perspective on current risk stratification was unknown. A cohort of 9944 Chinese patients with ASCVD was recruited and refined into very-high-risk (VHR) and non-VHR subgroups according to current guideline. Lp(a) plasma levels were divided by its concentration (<30, 30–50, 50–75, and ≥75 mg/dL) and percentile zones (<25th, 25–50th, 50–75th, 75–90th, ≥90th). Cardiovascular events (CVEs) occurred during an average of 38.5 months’ follow-up were recorded. We found that Lp(a) was increased with risk stratification of ASCVD increasing. Prevalence of CVEs had a significantly increasing trend with gradients of Lp(a) elevation in VHR but not in non-VHR subgroup. The adjusted HRs (95%CIs) for CVEs were 1.75(1.25–2.46) in the highest group of Lp(a) ≥75 mg/dL compared with the group of Lp(a) <30 mg/dL as the reference in overall patients, 2.18(1.32–3.58) in VHR subgroup and 1.43(0.93–2.18) in non-VHR subgroup, respectively. The adjusted HRs (95%CIs) at the highest grade of Lp(a) levels (≥90th) were 1.72(1.19–2.50) in overall population, 2.83(1.53–5.24) in VHR subgroup and 1.38(0.86–2.12) in non-VHR subgroup, respectively. These findings suggested that Lp(a) might contribute more to CVEs risk in VHR subgroup of ASCVD.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.773","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk 外周癌症的神经科学：肿瘤劫持神经与神经免疫串扰

IF 10.7

MedComm Pub Date : 2024-10-31 DOI: 10.1002/mco2.784

Hua-Yang Fan, Xin-Hua Liang, Ya-Ling Tang

{"title":"Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk","authors":"Hua-Yang Fan, Xin-Hua Liang, Ya-Ling Tang","doi":"10.1002/mco2.784","DOIUrl":"https://doi.org/10.1002/mco2.784","url":null,"abstract":"Cancer neuroscience is an emerging field that investigates the intricate relationship between the nervous system and cancer, gaining increasing recognition for its importance. The central nervous system governs the development of the nervous system and directly affects brain tumors, and the peripheral nervous system (PNS) shapes the tumor microenvironment (TME) of peripheral tumors. Both systems are crucial in cancer initiation and progression, with recent studies revealing a more intricate role of the PNS within the TME. Tumors not only invade nerves but also persuade them through remodeling to further promote malignancy, creating a bidirectional interaction between nerves and cancers. Notably, immune cells also contribute to this communication, forming a triangular relationship that influences protumor inflammation and the effectiveness of immunotherapy. This review delves into the intricate mechanisms connecting the PNS and tumors, focusing on how various immune cell types influence nerve‒tumor interactions, emphasizing the clinical relevance of nerve‒tumor and nerve‒immune dynamics. By deepening our understanding of the interplay between nerves, cancer, and immune cells, this review has the potential to reshape tumor biology insights, inspire innovative therapies, and improve clinical outcomes for cancer patients.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.784","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N6-methyladenosine reader YTHDF3-mediated zinc finger protein 41 inhibits hepatocellular carcinoma progression by transcriptional repression of Snail N6-甲基腺苷阅读器 YTHDF3 介导的锌指蛋白 41 通过转录抑制蜗牛抑制肝细胞癌的进展

IF 10.7

MedComm Pub Date : 2024-10-28 DOI: 10.1002/mco2.763

Xinxin Li, Mengzhen Han, He Zhu, Hongwei Zhang, Yonglong Pan, Huifang Liang, Zhibin Liao, Bixiang Zhang, Xiaoping Chen

{"title":"N6-methyladenosine reader YTHDF3-mediated zinc finger protein 41 inhibits hepatocellular carcinoma progression by transcriptional repression of Snail","authors":"Xinxin Li, Mengzhen Han, He Zhu, Hongwei Zhang, Yonglong Pan, Huifang Liang, Zhibin Liao, Bixiang Zhang, Xiaoping Chen","doi":"10.1002/mco2.763","DOIUrl":"https://doi.org/10.1002/mco2.763","url":null,"abstract":"Advanced metastasis of hepatocellular carcinoma (HCC) significantly contributes to high death rates among patients. The efficiency of targeted therapies and chemotherapeutic agents shows individual variability. Therefore, there is no effective treatment for advanced HCC. Zinc finger proteins (ZFPs) are known to be crucial in various tumors, especially on HCC. In our study, we verified that ZFP41 could suppress the progression and metastasis of HCC through in vitro and in vivo experiments. During the past years, N6-methyladenine (m6A) regulation has also been increasingly reported in HCC. To investigate whether ZFP41 could be regulated via m6A methylation, our results showed that YTHDF3 bound to the mRNA of ZFP41 and degrade it. Subsequently, to further elucidate the function of ZFP41, we identified Snail, a well-known oncogenic molecule, through RNA-seq. As a canonical component in the epithelial-to-mesenchymal transition (EMT) pathway, Snail plays a pivotal role and is a critical marker for tumor invasion and metastasis. Our results showed ZFP41 could inhibit Snail and the EMT pathway through its transcriptional repression. In conclusion, our study revealed that ZFP41 is a potential prognostic element for patients with HCC, and targeting ZFP41 might be used for translational clinical applications as a promising therapeutic target.","PeriodicalId":94133,"journal":{"name":"MedComm","volume":null,"pages":null},"PeriodicalIF":10.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mco2.763","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0