Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan最新文献

{"title":"Network Meta-analysis of the clinical efficacy and safety of kidney-tonifying and bone-strengthening therapies for the treatment of rheumatoid arthritis with kidney deficiency type.","authors":"Gan Chang, Tao Qingwen, Y I Haoying, Bian Yuting, Wang Jianming","doi":"10.19852/j.cnki.jtcm.20240927.002","DOIUrl":"10.19852/j.cnki.jtcm.20240927.002","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy and safety of different Traditional Chinese Medicine (TCM)-based kidney-tonifying and bone-strengthening therapies for rheumatoid arthritis (RA).</p><p><strong>Methods: </strong>The current Bayesian network Meta-analysis compared different TCM-based kidney-tonifying and bone-strengthening therapies for RA. Eight electronic databases and two trial registration platforms were searched. RevMan 5.4 and Stata 16 software were employed.</p><p><strong>Results: </strong>A total of 42 studies involving 3779 cases were included. The results showed that the most effective intervention for improving efficacy was Wanbi decoction; Bushen Quhan Zhiwang decoction was superior in reducing the incidence of adverse reactions; and Qiwei Tongbi oral liquid effectively reduced C-reactive protein and erythrocyte sedimentation rate levels.</p><p><strong>Conclusion: </strong>Combining TCMs with conventional Western Medicine can improve the clinical efficacy of RA treatments, reduce inflammatory indexes, and result in a higher safety profile. However, this conclusion needs to be verified by more high-quality randomized controlled trials.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1067-1081"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compound Tongyang Fumai decoction improves quality of life in sick sinus syndrome: a randomized controlled study.","authors":"W U Qiaomin, Guan Xuanke, Liu Jinfeng, Wang Yanli, Chang Xing, Liu Zhiming, Liu Ruxiu","doi":"10.19852/j.cnki.jtcm.2024.06.010","DOIUrl":"10.19852/j.cnki.jtcm.2024.06.010","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of Tongyang Fumai decoction (, TYFM) on the quality of life (QOL) as a complementary therapy for sick sinus syndrome (SSS).</p><p><strong>Methods: </strong>This randomized controlled study involved 224 patients with symptomatic SSS. Patients were randomly assigned to either the TYFM group or the control group (receiving theophylline sustained-release tablets). The primary endpoints included changes in average heart rate, the longest R to R (RR) interval, and the occurrences of long RR intervals. Secondary endpoints comprised the Short Form (SF)-36 questionnaires, the Self-Rating Anxiety Scale (SAS), and the Self-Rating Depression Scale (SDS).</p><p><strong>Results: </strong>TYFM significantly improved average heart rate (TYFM: 6 bpm <i>vs</i> control: 3 bpm, <i>P <</i> 0.01), shortened longest RR interval (TYFM: －0.20 s <i>vs</i> control: －0.0027 s, <i>P <</i> 0.05), and reduced numbers of long RR (TYFM: －99 <i>vs</i> control: －59, <i>P <</i> 0.01). In SF-36, TYFM enhanced physical and mental components (<i>P <</i> 0.01), outperforming the control group. TYFM also improved eight SF-36 dimensions significantly (<i>P <</i> 0.05 or <i>P <</i> 0.01). Regarding SAS and SDS, TYFM reduced scores significantly (<i>P <</i> 0.01), while SAS improved in the control group (<i>P <</i> 0.01), with no change in SDS. Statistically significant differences (<i>P <</i> 0.01) were observed in SAS and SDS between TYFM and control groups post-intervention.</p><p><strong>Conclusions: </strong>TYFM emerges as a promising alternative strategy for treating SSS, demonstrating favorable therapeutic effects and significant improvements in the quality of life for patients with SSS.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1247-1253"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics analysis reveals the neuroprotective effect of extract against Parkinson's disease in mouse.","authors":"Kang Sohi, Lee Sueun, Moon Byeong Cheol, Song Jun Ho, Kim Sung-Ho, Moon Changjong, Lee Soong-In, Kim Chul, Kim Joong Sun","doi":"10.19852/j.cnki.jtcm.2024.06.002","DOIUrl":"10.19852/j.cnki.jtcm.2024.06.002","url":null,"abstract":"<p><strong>Objective: </strong>To assess <i>Atractylodis Rhizoma Alba extract</i> (ARE) neuroprotective function in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice and related genes.</p><p><strong>Methods: </strong>Examined mRNA-DNA methylation changes induced by ARE in MPTP-induced Parkinson's disease (PD) model's substantia nigra.</p><p><strong>Results: </strong>ARE mitigated MPTP-induced motor impairment in rotarod and open field tests and preserved tyrosine hydroxylase-positive neuronal cells in substantia nigra and striatum. Genome RNA-Sequencing and Methyl-Sequencing in substantia nigra of vehicle/ARE-treated MPTP-induced PD mice showed 84 differentially expressed genes (DEGs) and 1804 differentially methylated regions (DMRs). Upregulated genes involved zinc ion homeostasis, cilium protein localization, and transcription; downregulated genes linked to ephrin receptor signaling, somitogenesis, and gene expression regulation. Hyper/hypomethylated DMRs post-ARE treatment associated with Wnt signaling, mitochondrial organization, dopamine biosynthesis, and hindbrain development. No significant correlation between DEGs and methylated genes related to PD pathogenesis.</p><p><strong>Conclusion: </strong>This research has identified the epigenetic targets of ARE's therapeutic action and gives insight on how ARE protects neurons in Parkinson's disease.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1111-1117"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2-hydroxy-3-methyl anthraquinone promotes apoptosis and inhibits invasion of human hepatocellular carcinoma cells by targeting nicotinamide adenine dinucleotide-dependent protein deacetylase sirtuin-1/cellular tumor antigen p53 signaling pathway.","authors":"W U Shuang, L I Qiao, Zhu Xieying, Zhang Taoyuan","doi":"10.19852/j.cnki.jtcm.20230904.005","DOIUrl":"10.19852/j.cnki.jtcm.20230904.005","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the anti-liver cancer effect of 2-hydroxy-3-methyl anthraquinone (HMA) and the specific mechanism based on nicotinamide adenine dinucleotide-dependent protein deacetylase sirtuin-1 (SIRT1)/cellular tumor antigen p53 (p53) pathway.</p><p><strong>Methods: </strong>Cell counting kit-8 method was used to observe the effect of HMA on the activity of human hepatocellular carcinoma cells (HepG2) cells. At 72 h and 80 μL HMA, the apoptosis rate of HepG2 cells in each group was measured by flow cytometry. Transwell was used to assay for cell invasion. The protein expression levels of SIRT1, p53, B-cell lymphoma-2 (Bcl-2), Bcl-2 associated X protein (Bax), caspase-9 (CASP9) and caspase-3 (CASP3) were detected by Western Blot.</p><p><strong>Results: </strong>HMA significantly inhibited the proliferation of HepG2 cells, The half inhibiting concentration (IC50) of the HMA at 24, 48 and 72 h were examined and it were 126.3, 98.6, and 80.55 μM, respectively. Compared with the control group, the apoptosis rate of HMA, Selisistat (EX527), and HMA+ EX527 groups enhanced, while the apoptosis rate of SRT1720 diminished, demonstrating that inhibition of SIRT1 can lead to apoptosis of HepG2 cells. HMA+ EX527 group had the highest apoptosis rate, the lowest expression of SIRT1 and Bcl-2, and the highest expression of p53, Bax, CASP9 and CASP3. The number of invasions of HepG2 was significantly reduced after HMA and EX527 intervened. Western blot shows HMA could inhibit SIRT1, promote the expression of p53, and decrease the ratio of Bcl-2/Bax.</p><p><strong>Conclusions: </strong>HMA induced apoptosis in HepG2 cells, while inhibiting proliferation and invasion. The mechanism of HMA against HCC may be related to the SIRT1/p53 pathway.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1104-1110"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy and safety evaluation of Buzhongyiqi pills on appetite improvement in patients with colorectal cancer receiving chemotherapy: a pilot randomized cross-over clinical trial.","authors":"Qian Jianan, X U Yan, H U Hongyi, Zhao Aiguang","doi":"10.19852/j.cnki.jtcm.20240806.005","DOIUrl":"10.19852/j.cnki.jtcm.20240806.005","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the clinical efficacy and safety of Buzhongyiqi pills (BZYQP, ) in improving the appetite of patients with colorectal cancer (CRC) receiving chemotherapy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Trial design: &lt;/strong&gt;A pilot, randomized, single-blind cross-over clinical trial was conducted on diagnosed stage II-IV CRC patients receiving chemotherapy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Patients were randomly assigned to either the BZYQP-placebo or placebo-BZYQP groups. The BZYQP-placebo group received BZYQP for 1-2 d before the first cycle of chemotherapy and continued until the end of the third cycle. A 7-day washout followed, after which they received a placebo until the end of the sixth cycle. The placebo-BZYQP group followed the opposite treatment order. The oral dose of BZYQP and placebo was ten pills three times daily. A total of 12 visit points were scheduled in this study, with each visit point carried out before and after each of the six cycles of chemotherapy. The Simplified Nutrition Appetite Questionnaire (SNAQ), the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30, version 3.0), and the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE, V5.0) were used to evaluate patient appetite, quality of life, and drug safety.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Totally 62 patients completed the study, and baseline characteristics were balanced between the BZYQP-placebo and placebo-BZYQP groups. The primary outcome, as assessed by SNAQ scores, demonstrates a statistically significant difference between the two groups during the first three cycles of chemotherapy, with the mean SNAQ score of the BZYQP-placebo group consistently higher than that of the placebo-BZYQP group from V1 (&lt;i&gt;P &lt;&lt;/i&gt; 0.001). After the washout period, the SNAQ score of the BZYQP-placebo group decreased from V7, and the difference in SNAQ scores between the two groups gradually became more significant after the intersection at V9. Secondary outcomes showed that during the first three cycles of chemotherapy, the BZYQP-placebo group had significantly lower scores in physical, role, emotional, cognitive, and social functioning domains, as well as in fatigue, loss of appetite, and diarrhea symptoms, compared to the placebo-BZYQP group (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). Scores for physical, role, emotional, cognitive, and social functioning in the BZYQP-placebo group remained lower (&lt;i&gt;P &lt;&lt;/i&gt; 0.05) at V11. The chemotherapy-induced adverse events (AEs) in the BZYQP-placebo group were significantly lower than those in the placebo-BZYQP group at V5, mainly in nausea and vomiting (9.1% &lt;i&gt;vs&lt;/i&gt; 62.1%, &lt;i&gt;P &lt;&lt;/i&gt; 0.001), diarrhea (12.1% &lt;i&gt;vs&lt;/i&gt; 44.8%, &lt;i&gt;P =&lt;/i&gt; 0.004), and anemia (15.2% &lt;i&gt;vs&lt;/i&gt; 41.4%, &lt;i&gt;P =&lt;/i&gt; 0.021). No drug-related events were reported in this study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;BZYQP is feasible and safe to effectively improve the appetite of patients with CRC receiving c","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1254-1267"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-oxidative and immunological role of Cyclocarya paliurus polysaccharide on the liver injury of diabetic rats.","authors":"Xia Xichao, Xue Shipeng, Song Guoying, L I Bin, Wang Huiping, Qiu Ju, Wang Jihong, Liu Qingchun, M A Yuhong, Ouyang Jingfeng","doi":"10.19852/j.cnki.jtcm.2024.06.005","DOIUrl":"10.19852/j.cnki.jtcm.2024.06.005","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of Cyclocarya paliurus (C. paliurus) polysaccharide on the liver injury of diabetic rats.</p><p><strong>Methods: </strong>Rats were divided into 6 groups, including normal group, model group, control group, low-dose group of C. paliurus polysaccharide treatment, middle-dose group of C. paliurus polysaccharide treatment and high-dose group of C. paliurus polysaccharide treatment. Histological analysis of liver was analyzed using hematoxilin and eosin. Levels of plasma biological parameters and anti-oxidative enzymes were determined by spectrophotometry. Nuclear factor kappa-B-p65 (NF-κB p65), tumor necrosis factor-α (TNF-α), interleukins 6 (IL-6), IL-1β were measured by real-time polymerase chain reaction and enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Compared with that of model group, the glucose level of plasma decreased 62.32% (<i>P</i> < 0.01), but glycogen and insulin level increased 1.51 times and 1.27 times in the high-dose group of C. paliurus polysaccharide treatment, respectively. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) level decreased 47.47% (<i>P <</i> 0.05), 43.65% (<i>P <</i> 0.05) and 50.51% (<i>P <</i> 0.05) in the high-dose group of C. paliurus polysaccharide treatment, respectively. Superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase level increased 1.16 times (<i>P <</i> 0.01), 71.28% (<i>P <</i> 0.05), 1.29 times (<i>P <</i> 0.01) and 87.46% (<i>P <</i> 0.05) in the high-dose group of C. paliurus polysaccharide treatment, respectively. Enzyme activities of NF-κB, TNF-α, IL-1β and IL-6 were decreased 39.29% (<i>P <</i> 0.05), 51.11% (<i>P</i> < 0.05), 37.42% (<i>P</i> < 0.05) and 36.50% (<i>P <</i> 0.05), respectively.</p><p><strong>Conclusions: </strong>Administration of C. paliurus polysaccharide may play a protecting role for liver injury of diabetic rats through lowering glucose, ALT, AST, ALP level, increasing glycogen and insulin level, enhancing the anti-oxidative ability and down-regulating the inflammatory factors expression.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1146-1152"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation indicators of Traditional Chinese Medicine syndromes for gouty arthritis with damp heat accumulation and the effect of administering Tongfeng Qingxiao formula.","authors":"Zhang Xiaoyun, L I Yongjin, L I Huanan, Chai Yuan, Cheng Feng, L I Binglin, Zhou Yi, Lai Yu","doi":"10.19852/j.cnki.jtcm.20240706.001","DOIUrl":"10.19852/j.cnki.jtcm.20240706.001","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the indicators of an animal model of gouty arthritis (GA) with dampness heat accumulation and the intervention effect of Tongfeng Qingxiao formula (, TFQXF).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Seventy-two healthy adult Sprague?Dawley male rats were selected and randomly divided into a normal group, model group, low-dose group, medium-dose group, high-dose group, and diclofenac group using a random number table method, with 12 rats in each group. After group intervention, the general condition of the rats in each group was monitored and recorded, and the swelling index was measured. After separating the serum, the changes in glutamic pyruvic transaminase (ALT), glutamic oxaloacetic transaminase (AST), carbamide (UREA), creatinine (CREA), triglyceride (TG), total serum cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) in the serum of the rats in each group were measured using an automatic biochemical analyzer. The levels of motilin (MTL), gastrin (GAS), endothelin (ET), calcitonin gene-related peptide (CGRP), heat shock protein 70 (HSP70), interleukin (IL)-1β, and nuclear factor kappa-B (NF-κB) in the serum of the rats in each group were evaluated using enzyme-linked immunosorbent assay (ELISA) kits. Kidney tissues were used to evaluate the protein and mRNA expression of aquaporin (AQP) 1 and AQP2. Colon tissue was used to evaluate the protein and mRNA expression of AQP3 and AQP4 by Western blotting (WB) assay and real-time quantitative polymerase chain reaction (RT?qPCR). The levels of ALT, AST, UREA, and CREA were used to evaluate the liver and kidney function of rats. The levels of MTL and GAS were used to evaluate the gastrointestinal function of rats. The levels of TG, TC, LDL-C, HDL-C, AQP1, AQP2, AQP3, and AQP4 were used to evaluate the \"dampness\" syndrome performance in rats. The levels of ET, CGRP, and HSP70 were used to evaluate the \"heat\" syndrome performance in rats. The levels of IL-1β and NF-κB were used to evaluate the degree of inflammation in rats. The pathological changes in synovial and colonic tissues were observed by hematoxylin and eosin staining.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Except for the normal group, after modeling treatment, the ankle joint of rats in both the model group and drug treatment groups gradually swelled, reaching a peak at 12 h, and then gradually began to subside. The results of biochemical analyzer detection indicated that the serum ALT, AST, UREA, CREA, TG, TC and LDL-C levels were significantly higher, but the HDL-C level was significantly lower in the rats of the model group than in the rats of the normal group (&lt;i&gt;P &lt;&lt;/i&gt; 0.05). The serum ALT, AST, UREA, CREA, MTL, TC and LDL-C levels were significantly lower, but the HDL-C level was significantly higher in the rats of all drug treatment groups than in the rats of the model group (&lt;i&gt;P &lt;&lt;/i&gt; 0.05). The results of ELISA detection indicated that the MTL","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1204-1216"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture reduces sedative and anaesthetic consumption and improves pain tolerance in patients undergoing colonoscopy: a Meta-analysis.","authors":"Wang Bingyu, Jin Fangfang, Gao Jiawei, Yang Liuxin, Zhang Yali, Yuan Xingxing, Zhang Yang","doi":"10.19852/j.cnki.jtcm.20240926.001","DOIUrl":"10.19852/j.cnki.jtcm.20240926.001","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of acupuncture anesthesia on the consumption of sedatives and anesthetics, pain, and time consumption in patients undergoing colonoscopy, thus providing evidence that acupuncture anesthesia should be extended to endoscopists and anesthetists.</p><p><strong>Methods: </strong>Four English and four Chinese databases were searched for randomised controlled trials of acupuncture anaesthesia in patients undergoing colonoscopy, published from database inception to 1 March 2023. Outcomes were consumption of sedatives and anaesthetics, pain tolerance, visual analog scale (VAS) score, the meantime consumption of examination, satisfaction, and adverse reactions.</p><p><strong>Results: </strong>Thirty-one randomized controlled trials with a total of 4790 participants were included. Results showed that acupuncture anaesthesia significantly reduced consumption of sedatives and anaesthetics [9 studies, <i>n</i> = 944, standardized mean difference (<i>SMD</i>) = －0.82, 95% <i>CI</i> (－1.31, －0.33), <i>P =</i> 0.001], VAS score [9 studies, <i>n</i> = 1790, mean difference (<i>MD</i>) = －1.13, 95% <i>CI</i> (－1.70, －0.57), <i>P</i> < 0.001], meantime consumption [21 studies, <i>n</i> = 3799, <i>MD</i> = －2.09, 95% <i>CI</i> (－3.15, －1.03)<i>, P</i><0.001] and adverse reactions of colonoscopy [7 studies, <i>n</i> = 738, odds ratio (<i>OR</i>) = 0.17, 95% <i>CI</i> (0.10, 0.28), <i>P</i><0.001]. Acupuncture also significantly improved pain tolerance [14 studies, <i>n =</i> 1661, <i>OR</i> = 7.05, 95% <i>CI</i> (3.79, 13.12), <i>P</i><0.001], while no beneficial effects were found for satisfaction [7 studies, <i>n =</i> 843, <i>SMD =</i> 0.02, 95% <i>CI</i> (－0.38, 0.43), <i>P</i> = 0.91].</p><p><strong>Conclusion: </strong>Acupuncture has beneficial effects on patients undergoing colonoscopy, particularly in reducing consumption of sedatives and anaesthetics, alleviating pain, shortening the time consumption of examination and preventing adverse events. As an alternative, effective, inexpensive, and accessible approach, acupuncture anaesthesia should be extended to endoscopists and anaesthesiologists.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1091-1103"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted serum metabonomic reveals alleviated ovalbumin-induced asthma by Baijin Pingchuan through primary bile acid biosynthesis.","authors":"Ding Lizhong, Zhang Qiang, Sun Yingying, Kong Yibu, Song Yongfu, Wang Yongji","doi":"10.19852/j.cnki.jtcm.2024.06.007","DOIUrl":"10.19852/j.cnki.jtcm.2024.06.007","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of baijinpingchuan (, BJPC) on the asthma rat model and identify differential metabolites and disturbed metabolic pathways.</p><p><strong>Methods: </strong>The rats were categorized into six groups: control, dexamethasone (DEX), ovalbumin (OVA), and low-, median-, and high-dose BJPC. The rats, except for the control group, were initially treated with OVA to develop the asthma model, which was then activated using DEX, OVA, and low-, median-, and high-dose BJPC. Enzyme-linked immunosorbent assay kit was used to detect the expression of interleukin (IL)-33, IL-25, thymic stromal lymphopoietin (TSLP), and transforming growth factor-beta 1 (TGF-β1). Hematoxylin and eosin staining were performed to observe the pathological condition of the lung. Untargeted serum metabonomic analysis was conducted to identify differential metabolites and disturbed metabolic pathways.</p><p><strong>Results: </strong>High-dose BJPC significantly inhibited the expression of IL-33, IL-25, TSLP, and TGF-β1 (<i>P <</i> 0.0001). Further, high-dose BJPC improved inflammatory cell infiltration, which plays a similar role in asthma as DEX. OVA-induced and BJPC-treated rats were identified through 17 differential metabolites, especially cholic acid. Furthermore, primary bile acid biosynthesis was a significantly differential pathway in the mechanism of BJPC for treating asthma.</p><p><strong>Conclusions: </strong>BJPC plays an anti-inflammation role in asthma, which might be a promising therapy through mediating primary bile acid biosynthesis.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1187-1193"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bufei Huoxue capsule alleviates silicosis by inhibiting the activation of nucleotide-like receptor containing pyrin domain 3 inflammasome and macrophages polarization based on network pharmacology.","authors":"Hang Wenlu, Wang Lin, B O Yun, Zuo Shurun, Wang Songquan, L I Haiquan, B U Chunlu, Zhao Jie, Zhou Xianmei","doi":"10.19852/j.cnki.jtcm.20240626.004","DOIUrl":"10.19852/j.cnki.jtcm.20240626.004","url":null,"abstract":"<p><strong>Objective: </strong>To predict the targets of Bufei Huoxue capsule (, BFHX) using network pharmacology analysis and to explore its effects and functional targets in a silicotic rat model.</p><p><strong>Methods: </strong>The drug and disease targets were correlated through network pharmacology analysis to explore the targets and signaling pathways of BFHX affecting silicosis. NR8383 cells were cultured to verify the core genes and pathways. A rat model of silicosis was established to verify whether the mechanism behind SiO2-caused pulmonary fibrosis was alleviated by BFHX (0.82 g/kg) and how it affected key targets and pathways.</p><p><strong>Results: </strong>Overlapping BFHX and silicotic gene targets produced 159 interactive targets, and 55 were screened by network topology analysis. The results of gene ontology and Kyoto encyclopedia of genes and genomes enrichment analyses suggested that BFHX could affect silicosis through the nucleotide-like receptor containing pyrin domain 3 (NLRP3) inflammasome. In NR8383 cells, the expression of core genes related to the NLRP3 inflammasome could be inhibited by BFHX treatment. BFHX reduced the degree of alveolitis and collagen deposition, attenuating pulmonary fibrosis in SiO2-induced rat model. Pulmonary macrophage pyroptosis after SiO2 exposure was observed under transmission electron microscopy. BFHX alleviated the morphological characteristics of pyroptosis. BFHX also reduced the expression of NLRP3, caspase-1, interleukin-1 beta (IL-1β), IL-18, IL-6, and tumor necrosis factor-alpha in lung tissues of silicotic rat model. BFHX affected the K ion content in bronchoalveolar lavage fluid when assessed by energy dispersive spectrometer testing. The expression of CD68+ and CD206+ were also reduced after BFHX intervention.</p><p><strong>Conclusion: </strong>NOD-like receptor signaling is vital for BFHX's effects on silicosis. It exerts anti-pulmonary fibrosis effects by inhibiting pulmonary macrophage pyroptosis and polarization through NLRP3 inflammasome activation.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1236-1246"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}