Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan最新文献

{"title":"Yiqi Huoxue formula relieves heart failure with reduced ejection fraction in calcium/calmodulin-dependent protein kinase Ⅱ delta B isoform and calcium/calmodulin-dependent protein kinase Ⅱ delta C isoform transgenic mice by inhibiting myocardial remodeling and enhancing calcium homeostasis.","authors":"X U Jianglin, Shi Xiaolu, L I Yan, Zhou Kun, L I Peng, L I Sinai, L U Jinjin, Chen Yajun, Zhan Nannan, Zhang Ruotong, Cheng Bairu, Lin Qian, Wan Jie, Liu Jing","doi":"10.19852/j.cnki.jtcm.20260214.001","DOIUrl":"10.19852/j.cnki.jtcm.20260214.001","url":null,"abstract":"<p><strong>Objective: </strong>To confirm the efficacy of Yiqi Huoxue formula (, YQHX) on heart failure with reduced ejection fraction (HFrEF), and elucidate its potential effect on calcium homeostasis.</p><p><strong>Methods: </strong>Cardiac specific calcium/calmodulin-dependent protein kinase II delta C isoform (CaMKⅡδC)-overexpression transgenic mice (C-CaMKⅡδC^+/- Tg mice) and calcium/calmodulin-dependent protein kinase II delta B isoform (CaMKⅡδB)-overexpression transgenic mice (C-CaMKⅡδB^+/- Tg mice) were established by clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 technique, and their genotypes and phenotypes were identified thereafter. C57BL/6 mice and transgenic mice were divided into seven groups in random, each containing eight mice. The groups were Control group, CaMKⅡδB model group, CaMKⅡδB treatment group (B Treated), CaMKⅡδB inhibitor group (B Inhibitor), CaMKⅡδC model group (C Model), CaMKⅡδC treatment group (C Treated), CaMKⅡδC inhibitor group (C Inhibitor). B and C Treated groups were given YQHX once a day for 4 weeks by gavage. The cardiac function and structure were evaluated using echocardiogram. The myocardial cellular status and fibrosis were detected by hematoxylin and eosin staining and Masson staining. Calcium transients and calcium leakage from cardiac ventricular myocytes were detected to reflect calcium homeostasis, and the expressions of CaMKⅡδB, CaMKⅡδC, hypertrophy factors, calcium pathway-related genes, and the level of calcium handling proteins were assessed by western blotting and reverse transcription-quantitative polymerase chain reaction.</p><p><strong>Results: </strong>We found CaMKⅡδB and CaMKⅡδC transgenic mice showed HFrEF phenotype. YQHX improved the systolic function of the CaMKⅡδB transgenic mice, reduced the cross-sectional area of cardiomyocytes, inhibited the overexpression of CaMKⅡδB and hypertrophy-related genes (B-type natriuretic peptide, myocyte enhancer factor 2, and atrial natriuretic factor), and increased calcium handling protein sarcoendoplasmic reticulum Ca²⁺ adenosine triphosphatase 2a (SERCA2a) and calcium capacity. YQHX improved the cardiac systolic function of CaMKⅡδC transgenic mice, reduced the ventricular diameter and cardiomyocyte cross-sectional area, alleviated myocardial fibrosis, increased SERCA2a expression and calcium capacity, and reduced calcium leakage.</p><p><strong>Conclusion: </strong>Our results suggest that YQHX improved HFrEF by inhibiting CaMKIIδB overexpression, which may be related to reduced expression of hypertrophy-related factors, and increased SERCA2a expression to increase calcium reserve. In addition, YQHX improved HFrEF by inhibiting CaMKIIδC overexpression, which may be related to reduce calcium leakage, and increase SERCA2a expression to increase calcium reserve.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"530-543"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicenter randomized controlled trial and metabolomics exploration of Traditional Chinese Medicine pattern-based therapy for stable chronic obstructive pulmonary disease.","authors":"Ding Huanzhang, Wang Hui, Yang Qinjun, M A Xiao, W U Di, L I Qiao, Zheng Caixia, L U Jiasheng, W U Chengming, Huang Pingfu, Chen Zhixiang, Wang Shihan, Feng Jihong, Liu Jian, Sun Dengdi, Zhu Jie, Tong Jiabing, Gao Yating, L I Zegeng","doi":"10.19852/j.cnki.jtcm.20260206.001","DOIUrl":"10.19852/j.cnki.jtcm.20260206.001","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of Traditional Chinese Medicine (TCM) pattern-based comprehensive therapy on stable chronic obstructive pulmonary disease (COPD) patients and its influence on metabolic profiles.</p><p><strong>Methods: </strong>In this multicenter trial, 270 participants from nine hospitals were randomly divided into a trial group and a control group at a 1∶2 ratio. The trial group received Tiotropium Bromide Powder for Inhalation (TBPI) plus one of three TCM granules [Shenqi Wenfei formula, Shenqi Buzhong formula, or Shenqi Tiaoshen formula], while the control group got only TBPI. The study had a 24-week treatment and 52-week follow-up. The main outcome was the frequency of acute COPD exacerbations. Secondary outcomes included related rates, scores on COPD assessment test (CAT) and modified medical research council (mMRC) dyspnea scale, 6-min walk test (6MWT) distance, and lung function, measured at weeks 0, 24, and 52. Serum samples for metabolomics were taken from the trial group before/after treatment and from healthy people.</p><p><strong>Results: </strong>A total of 256 out of 270 patients completed the study. The trial group had fewer acute exacerbations than the control group during 52-week follow-up (<i>P <</i>0.05). At 24 weeks, the trial group improved in CAT, mMRC, and 6MWT compared to the control (<i>P <</i>0.05), with mMRC and 6MWT improvements lasting at week 52. Lung function showed no significant group differences. Metabolomics found 32 different metabolites between healthy and pre-treatment patients, 17 reversing post-treatment. Bioinformatics showed pathway changes in pre-treatment patients reversed after treatment.</p><p><strong>Conclusion: </strong>TCM pattern-based comprehensive therapy reduces acute exacerbation risk and improves quality of life, respiratory symptoms, and exercise tolerance in stable COPD patients, likely by modulating energy, protein, and amino acid metabolism pathways.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"652-665"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cheek acupuncture therapy combined with Chinese herbal medicine for female chronic pelvic pain: a retrospective study.","authors":"Song Ying, You Yalin, Liao Yiru, H U Luodan, Wang Danna, Nie Guangning","doi":"10.19852/j.cnki.jtcm.2026.03.012","DOIUrl":"10.19852/j.cnki.jtcm.2026.03.012","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of cheek acupuncture therapy combined with Chinese herbal medicine on chronic pelvic pain (CPP) in female patients.</p><p><strong>Methods: </strong>Female patients with CPP treated with cheek acupuncture (CA) and Chinese herbal medicine (CHM) from January 2018 to March 2022 were retrospectively analyzed. The patients were divided into an observation group receiving CA combined with CHM and a control group receiving only CHM. Baseline and follow-up assessments were conducted using the visual analogue scale (VAS), the McCormack scale, and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) quality of life assessment questionnaire. Prognostic differences were analyzed by comparing pain recurrence rates during follow-up. Baseline and follow-up assessments were conducted using the VAS, the McCormack scale, and the SF-36 quality of life assessment questionnaire. Prognostic differences were analyzed by comparing pain recurrence rates during follow-up.</p><p><strong>Results: </strong>A total of 255 patients with CPP were included, with 113 assigned to the observation group and 142 to the control group. There was no significant difference in baseline characteristics between the two groups (<i>P</i> > 0.05). After treatment, patients in the observation group showed significantly lower VAS scores and McCormack scale scores, as well as higher SF-36 scores, than the control group. Additionally, the treatment group had a lower recurrence rate during follow-up.</p><p><strong>Conclusion: </strong>The combination of CA therapy and CHM shows high safety and efficacy, and a low CPP recurrence rate in women.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"726-732"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of the Chinese herbal medicine Xiao'er Niuhuang antipyretic plaster for treating fever in children with acute upper respiratory tract infection with wind-heat syndrome: a multicenter, randomized, double-blind, controlled clinical trial.","authors":"Liu Na, Chen Zhimin, Zhao Gang, Yuan Bin, Huang Zhijun, Zhang Xuerong, Song Guihua, Chen Huafang","doi":"10.19852/j.cnki.jtcm.20250930.001","DOIUrl":"10.19852/j.cnki.jtcm.20250930.001","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of Xiao'er Niuhuang antipyretic plaster in treating fever associated with acute upper respiratory tract infection (AURI) accompanied by wind-heat syndrome in children.</p><p><strong>Methods: </strong>A total of 464 pediatric patients diagnosed with AURI and wind-heat syndrome were enrolled. Participants were stratified into two age subgroups (1-2 years and 3-5 years) and then randomly assigned in a 3:1 ratio to receive either the Xiao'er Niuhuang antipyretic plaster or an extremely low-dose control plaster. The primary outcome was the time to onset of fever reduction. Safety assessments included monitoring of vital signs, laboratory tests (complete blood count, urinalysis, stool routine, and liver and kidney function), electrocardiogram, and local skin reactions.</p><p><strong>Results: </strong>The median time to onset of antipyretic effect was significantly shorter in the Xiao'er Niuhuang antipyretic plaster group than in the control group (2.53 h <i>vs</i> 3.98 h). The complete antipyretic rates at the 4-h time point were 31.76% for the Xiao'er Niuhuang antipyretic plaster group and 17.70% for the control group; at the 8-h time point, the rates were 49.55% and 33.04%, respectively. No significant difference was observed in the incidence of adverse events between the two groups (<i>P ></i>0.05). No serious adverse events were reported.</p><p><strong>Conclusion: </strong>Xiao'er Niuhuang antipyretic plaster is an effective and safe treatment for fever in children with AURI and wind-heat syndrome.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"666-673"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of Jichuan decoction in slow-transit constipation: focus on gut microbiota modulation.","authors":"Wang Xiumin, Lü Lixia, L I Jianghua, Chen Jilan, Tan Cailin, Ding Weijun","doi":"10.19852/j.cnki.jtcm.2026.03.002","DOIUrl":"10.19852/j.cnki.jtcm.2026.03.002","url":null,"abstract":"<p><strong>Objective: </strong>To clarify the therapeutic mechanisms of Jichuan decoction (, JCD) in slow-transit constipation (STC), we focused on its neuromuscular and microbiota-modifying effects.</p><p><strong>Methods: </strong>An STC mouse model was induced by administering diphenoxylate for 14 consecutive days. The experimental groups included healthy controls (HC), a saline-treated STC model group, a mosapride-treated positive control group (MSP), and JCD-treated groups at different dosages. Gastrointestinal motility was evaluated first by black stool latency and then by colonic 5-hydroxytryptamine and substance P levels. Neural markers were assessed by real-time quantitative reverse transcription polymerase chain reaction, and glial-derived neurotrophic factor (GDNF) and central nervous system specific protein β (S100β) levels were measured via enzyme-linked immunosorbent assay. Histopathological analysis was performed via hematoxylin-eosin and periodic acid-Schiff staining. Microbial profiling was conducted via 16S rRNA sequencing.</p><p><strong>Results: </strong>JCD treatment improved intestinal motility in STC mice, increased colonic neurotransmitter levels, increased mucosal thickness and goblet cell density, upregulated protein gene product 9.5 and GDNF, downregulated neuronal nitric oxide synthase and S100β, and reversed dysbiosis through the enrichment of Akkermansia muciniphila.</p><p><strong>Conclusion: </strong>JCD alleviates STC by restoring enteric nervous system function and gut microbiota homeostasis, indicating its potential for STC management.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"544-551"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of gamma-aminobutyric acid-ergic neurons in the thalamic reticular nucleus in regulating sleep-wake cycles in mice treated with acupuncture for insomnia.","authors":"L U Xiaoxiao, X U Yipeng, Zhou Minjie, Zhang Chengshun, Cai Dingjun, Zhao Zhengyu","doi":"10.19852/j.cnki.jtcm.2026.03.003","DOIUrl":"10.19852/j.cnki.jtcm.2026.03.003","url":null,"abstract":"<p><strong>Objective: </strong>To test whether acupuncture improves sleep by enhancing gamma-aminobutyric acid-ergic (GABA) neuronal activity in the thalamic reticular nucleus (TRN).</p><p><strong>Methods: </strong>We established an animal model using p-chlorophenylalanine (PCPA). We assessed the impact of acupuncture on insomnia through wheel-running activity and sodium pentobarbital-induced sleep tests. Subsequently, the calcium indicator GCaMP6m was injected into the TRN of Vgat-Cre mice, and the activity of GABA neurons in the TRN was analyzed before and after acupuncture using fiber photometry recording. Additionally, cortical electroencephalography (EEG) recordings were compared between groups following chemogenetic inhibition of GABA neurons in the TRN.</p><p><strong>Results: </strong>Following acupuncture, we observed a reduction in sleep latency and an increase in sleep duration in comparison to the PCPA-induced insomnia (<i>P</i> < 0.01). Furthermore, acupuncture positively influenced the diurnal phase of insomnia (<i>P</i> < 0.01). Ca²⁺ signals in GABA neurons within the TRN increased post-acupuncture (paired <i>t-</i>test, <i>P</i>< 0.01). Acupuncture also reduced the proportion of EEG power in the elevated Beta and Gamma frequencies associated with PCPA injection, while simultaneously increasing the Delta power ratio (<i>P</i> < 0.01). Chemogenetic inhibition of TRN GABA neurons blocked these acupuncture effects: the hM4Di + MA group showed no significant differences from the PCPA group in Beta and Gamma power, but exhibited elevated Beta and Theta activity compared to controls (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>Acupuncture activates GABA neurons in the TRN, thereby regulating the sleep-wake cycle in the context of PCPA-induced insomnia.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"552-560"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of the nucleus nuclear factor erythroid 2-related factor 2ghrelin/growth hormone secretagogue receptor 1a signaling by Yueju pill confers cardioprotective and antidepressant effects.","authors":"Jing Yunjia, Y E Zhaoyi, Zhu Yan, Gao Xin, Chen Xi, Wang Kaixuan, Huang Dafeng, H U Yue, Jiang Jiancong","doi":"10.19852/j.cnki.jtcm.2026.03.001","DOIUrl":"10.19852/j.cnki.jtcm.2026.03.001","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the efficacy and mechanistic foundations of the Traditional Chinese Medicine Yueju pill (YJP, ) for treating the complex comorbidity of heart failure and depression.</p><p><strong>Methods: </strong>C57BL/6 male mice were used to establish a robust congestive heart failure (CHF) model with concomitant depressive manifestations. Echocardiographic assessments were conducted to evaluate cardiac structure and function in the mice. Depression-related behavioral tests and the detection of monoamine neurotransmitters were performed to assess the antidepressant-like effectiveness of YJP. Western blot analysis was conducted to measure the expression levels of key components in the nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase 1 (HO1) antioxidant pathway, NRF2/brain-derived neurotrophic factor (BDNF) pathway, and ghrelin/growth hormone secretagogue receptor (GHS-R)1a pathway in the myocardium and hippocampus. To explore the mechanistic role of the ghrelin/GHS-R1a pathway, the ghrelin receptor antagonist D-Lys3-growth hormone-releasing peptide-6 was introduced to enable the iterative evaluation of the aforementioned parameters.</p><p><strong>Results: </strong>YJP improved cardiac dysfunction and myocardial fibrosis and markedly ameliorated depressive behaviors. It also improved neuron damage, boosted the growth of dendritic spines to enhance synaptic plasticity, and alleviated monoamine neurotransmitter imbalances. Additionally, the NRF2/BDNF, ghrelin/GHS-R1a, and NRF2/HO1 antioxidant pathways were promoted by YJP, with the increased expression of key components of the three pathways. The addition of a GHS-R1a antagonist impaired the antidepressant and cardioprotective effects of YJP.</p><p><strong>Conclusions: </strong>YJP effectively improved cardiac dysfunction and depressive-like behaviors in mice by activating NRF2 <i>via</i>mediation of the ghrelin/GHS-R1a signaling axis within both the myocardial and hippocampal domains.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"517-529"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the fear of cancer recurrence and Traditional Chinese Medicine constitution in breast cancer patients: a cross-sectional study.","authors":"Wang Runxi, Fang Liyuan, Wang Yan, Xie Yi, Fang Yuhang, Sui Bailu, Yuan Xinhe, Chen Yu, Zhang Ying","doi":"10.19852/j.cnki.jtcm.2026.03.011","DOIUrl":"10.19852/j.cnki.jtcm.2026.03.011","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between Traditional Chinese Medicine (TCM) constitution and fear of cancer recurrence (FCR) in breast cancer survivors.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among breast cancer patients at Guang'anmen Hospital of the Chinese Academy of Traditional Chinese Medicine, China, during the period from April 9, 2023, to July 2, 2024. Data were collected on participants' common sociodemographic characteristics, medical history, scores on the Fear of Cancer Recurrence Inventory (FCRI), and TCM constitution classification. Statistical analyses employed independent samples <i>t</i>-test, <i>χ</i> ² test, Fisher's exact test, one-way analysis of variance, Spearman's correlation coefficient, multiple linear regression analysis, and multivariate logistic regression analysis.</p><p><strong>Results: </strong>A total of 279 eligible breast cancer patients enrolled in this study. The most prevalent TCM constitutions were '<i>Qi</i>-depression', 'Peaceful' and '<i>Yang</i>-deficiency'. All nine TCM constitutions of breast cancer patients exhibited significant correlations with FCR scores. The strongest positive correlation was observed between '<i>Qi</i>-stagnation' and FCR (<i>r</i>= 0.5576, <i>P <</i> 0.0001), followed by '<i>Qi</i>-deficiency' (<i>r</i> = 0.4465, <i>P <</i> 0.0001). By contrast, the Peaceful correlation showed a significant negative correlation with FCR (<i>r</i> = －0.363, <i>P <</i> 0.0001). Multiple linear regression analysis showed that TCM constitution, lymph node metastasis, and endocrine therapy were influencing factors for FCR in breast cancer patients (<i>P <</i> 0.05). Additionally, multivariate logistic regression analysis was performed to identify factors associated with TCM constitution in breast cancer patients. After adjusting for potential confounding factors including age, disease stage, pathological type, immunohistochemical status, lymph node metastasis, disease duration, and treatment modality, FCR, disease stage, age, and surgical modality were found to be significantly associated with TCM constitution (all <i>P <</i> 0.05).</p><p><strong>Conclusion: </strong>This study demonstrates a significant association between TCM constitution and FCR in breast cancer patients, suggesting that FCR can potentially be interpreted within the theoretical framework of TCM. These findings thus provide a theoretical foundation for TCMC-informed management strategies targeting FCR in breast cancer patients.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"715-725"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of Buzhong Yiqi decoction for Hashimoto's thyroiditis: insights from gut microbiota and metabolomics.","authors":"Chen Ying, Qiao Jiajun, L U Yuyuan, Xue Chongxiang, Xia Zhongyuan","doi":"10.19852/j.cnki.jtcm.2026.03.005","DOIUrl":"10.19852/j.cnki.jtcm.2026.03.005","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of Buzhong Yiqi decoction (BZYQ) and its potential mechanism by conducting a comprehensive analysis of intestinal microbiota and metabolomics in autoimmune thyroiditis (AIT) rats.</p><p><strong>Methods: </strong>An AIT model with antibiotic cocktail were established. After 8 weeks of intervention with BZYQ, the levels of anti-thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TGAb) were measured. Pathological changes were assessed using hematoxylin and eosin staining. Changes of gut microbiota and fecal metabolites were analyzed through 16S RNA sequencing and metabolomics analysis.</p><p><strong>Results: </strong>BZYQ intervention improved pathological damage of thyroid gland in AIT rats and significantly reduced the levels of anti-thyroid antibodies. Additionally, it had an ameliorative effect on the pathological damage of the colon. Also, BZYQ increased the abundance of Lactobacillus reuteri, reversing the dysbiosis of the gut microbiota. And BZYQ could regulate tryptophan metabolism of tryptophan to reverse metabolic disorders in HT. The correlation analysis indicated a close relationship between tryptophan metabolism and Lactobacillus reuteri.</p><p><strong>Conclusions: </strong>BZYQ is a promising therapeutic approach for HT. Its mechanism in treating HT may be associated with the regulation of gut microbiota dysbiosis and the improvement of gut-derived metabolic disorders.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"571-583"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of acupoint sensitization in patients with essential hypertension: a cross-sectional matched case-control study.","authors":"Gong Yu, Hao Xiaomin, Liu Qingguo, Tian Junjian, Liu Yu","doi":"10.19852/j.cnki.jtcm.20251030.001","DOIUrl":"10.19852/j.cnki.jtcm.20251030.001","url":null,"abstract":"<p><strong>Objective: </strong>To observe the characteristics of acupoint sensitization in patients with essential hypertension, analyze the mechanical pain threshold and tenderness threshold of each acupoint, and summarize the clinical characteristics of high-sensitivity acupoints.</p><p><strong>Methods: </strong>This study employed a cross-sectional matched case-control design and enrolled a total of 448 volunteer participants, including 224 patients with hypertension and 224 healthy controls. The main outcome measures included measuring the mechanical pain threshold and tenderness threshold of 16 highly sensitive acupoints in both hypertensive subjects and healthy controls. The receiver operating characteristic curve method was used to evaluate the sensitivity of each acupoint. Additionally, the rules of mechanical pain threshold, tenderness threshold sensitization rate, and degree of sensitization of each acupoint in hypertension patients were summarized to identify the optimal highly sensitive acupoints related to hypertension.</p><p><strong>Resuits: </strong>The mechanical pain threshold and tenderness threshold of hypertensive patients were significantly lower than those of healthy subjects, the difference was statistically significant (<i>P <</i> 0.001), indicating that the mechanical pain threshold and tenderness threshold of hypertensive patients at various points had a downward trend. Acupoints with high incidence of sensitization in hypertensive patients include Quchi (LI11), Taichong (LR3), Fenglong (ST40), Xingjian (LR2), Taixi (KI3) and Renying (ST9).</p><p><strong>Conclusion: </strong>This study successfully achieved the objective of exploring acupoint sensitization in patients with primary hypertension. Hypertensive patients exhibited significantly lower mechanical pain thresholds and pressure pain thresholds compared to healthy subjects. These findings provide clinical evidence for acupoint selection in acupuncture treatment for primary hypertension.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 3","pages":"684-694"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}