Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan最新文献

{"title":"Clinical observation on the effect of warming meridian medicinal wine, polarized light external application combined with acupuncture and moxibustion on pain after vertebroplasty.","authors":"Wen Zhigang, L U Shuai, Cheng Xiumei","doi":"10.19852/j.cnki.jtcm.2025.03.018","DOIUrl":"10.19852/j.cnki.jtcm.2025.03.018","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of external application of warm meridian medicated wine and polarized light therapy combined with acupuncture on pain management following vertebroplasty.</p><p><strong>Methods: </strong>A total of 120 patients with osteoporotic vertebral compression fractures treated by vertebroplasty at our hospital were divided into four groups. The control group received non-steroidal anti-inflammatory drugs, the Treatment Group Ⅰ received acupuncture alone, Treatment Group Ⅱ was treated with medicated wine for warming meridians alongside polarized light physiotherapy, and Treatment Group Ⅲ received a combination of medicated wine for warming meridians, polarized light therapy, and acupuncture. The clinical efficacy, pain thresholds at various time points, temperature pain threshold, electric pain threshold, quality of life, sleep quality index, lumbar dysfunction index, visual analog scale (VAS) scores, and incidence of adverse reactions were compared and analyzed across the four groups.</p><p><strong>Results: </strong>The total clinical effective rate in Treatment Group Ⅲ was significantly higher than that in the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ (<i>P <</i> 0.05). At 24 and 72 h post-treatment, the VAS scores, temperature pain thresholds, and electric pain thresholds in Treatment Group Ⅲ were significantly lower than those in the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ (<i>P <</i> 0.05). Additionally, quality-of-life scores in Treatment Group Ⅲ were markedly higher compared to the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ, while the Pittsburgh Sleep Quality Index scores, Oswestry Disability Index scores, and incidence of adverse reactions in Treatment Group Ⅲ were significantly lower than in the other groups (<i>P <</i> 0.05).</p><p><strong>Conclusion: </strong>The external application of warm meridian medicated wine and polarized light therapy combined with acupuncture significantly reduces postoperative pain following vertebroplasty, enhances lumbar function, and improves both sleep quality and overall quality of life for patients. This approach is recommended for clinical application.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 3","pages":"660-666"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the mechanism of Shenhua tablet alleviating renal injury by regulating macrophage glycolysis hypoxia-inducible factor-1α/ pyruvate kinase M2 signaling pathway in diabetic kidney disease mice.","authors":"Chen Yuanchun, Jing Jiaxing, L I Qingmin, Zhou Xiaohong, Jin Xiaofei, Gao Weijuan, Chen Xiangmei, Y U Wentao","doi":"10.19852/j.cnki.jtcm.2025.03.009","DOIUrl":"10.19852/j.cnki.jtcm.2025.03.009","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the impact of Shenhua tablet (, SHT) on renal macrophage polarization and renal injury in mice with diabetic kidney disease (DKD)and to explore the potential mechanism involving the hypoxia-inducible factor-1α (HIF-1α) and pyruvate kinase M2 (PKM2) signaling pathway, along with the glycolysis metabolism pathway.</p><p><strong>Methods: </strong>The animals were divided into the following groups: Model, Control, dapagliflozin, SHT low-dose, SHT medium-dose, and SHT high-dose. We assessed 24-hour urine protein (24 h-UTP) levels, urinary albumin-to-creatinine ratio, and regularly monitored fasting blood glucose during the treatment period. After treatment, we examined renal tissue structure, renal function (urea nitrogen, uric acid, creatinine, cystatin C, β2-microglobulin), and glycolysis in renal macrophages. Additionally, we observed macrophage polarization in renal tissue and measured inflammatory factors (tumor necrosis factor-α, interleukin-1β, interleukin-6, interleukin-10, monocyte chemoattractant protein-1) to assess the immunoinflammatory status of the renal tissue. Finally, we investigated the expression of the HIF-1α/ PKM2 signaling pathway in macrophages to explore its role in the glycolysis process.</p><p><strong>Results: </strong>SHT shows a beneficial effect in treating DKD by reducing 24 h-UTP, regulating blood glucose levels, improving renal tissue structure, protecting renal function, inhibiting macrophage glycolysis, reducing macrophage transformation to the M1 state, and suppressing the expression of the HIF-1α/PKM2 signaling pathway.</p><p><strong>Conclusion: </strong>SHT may exert renoprotective effects by inhibiting macrophage glycolysis <i>via</i> the HIF-1α/PKM2 signaling pathway. This inhibition decreases macrophage M1 polarization and reduces immunoinflammatory injury in the renal tissue of DKD mice.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 3","pages":"528-537"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jatropholone B from Jatropha curcas inhibits melanin synthesisextracellular signal-regulated kinase activation in Mel-Ab cell.","authors":"Harfina Finanda Anwar, Chang Seok Park, Marianti Manggau, Hye-Young Yun, Dong-Seok Kim","doi":"10.19852/j.cnki.jtcm.2025.03.005","DOIUrl":"10.19852/j.cnki.jtcm.2025.03.005","url":null,"abstract":"<p><strong>Objective: </strong>In the present study, we investigated the effects of jatropholone B from <i>Jatropha curcas</i> (<i>J. curcas</i>) on melanin synthesis in Mel-Ab cells.</p><p><strong>Methods: </strong>Mel-Ab cells were cultured to measure melanin content and tyrosinase activities. Western blotting was performed to investigate jatropholone B-induced signal transduction and measure the expression of melanogenic proteins.</p><p><strong>Results: </strong>Jatropholone B decreased melanin synthesis in a concentration-dependent manner but did not directly inhibit the activity of tyrosinase, a melanogenic enzyme. Instead, jatropholone B downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase protein levels. Therefore, we investigated jatropholone B-induced signal transduction related to MITF and tyrosinase expression. However, jatropholone B had no significant effect on Akt and glycogen synthase kinase-3β phosphorylation as well as β-catenin change. In contrast, jatropholone B was observed to phosphorylate extracellular signal-regulated kinase (ERK) for the first time. To clarify the involvement of ERK activation in jatropholone B-induced hypopigmentation, we pretreated cells with PD98059, a specific ERK pathway inhibitor, and measured MITF and tyrosinase levels as well as melanin content. PD98059 pretreatment abrogated jatropholone B-induced downregulation of MITF and tyrosinase expression as well as reduction in melanin production.</p><p><strong>Conclusions: </strong>Based on these results, we suggest that ERK activation by jatropholone B inhibits melanogenesis <i>via</i> the downregulation of MITF and tyrosinase expression. Therefore, jatropholone B from J. curcas can be a candidate for developing a new skin-whitening agent.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 3","pages":"485-492"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotating-pulling-poking manipulation in gait analysis for lateral ankle sprain treatment.","authors":"Feng Mingshan, Wen Haibao, Zhao Wenlong, Han Changxiao, Gao Chunyu, L I Luguang, Zou Jinqiao, D U Wuyin, Zhu Liguo, Gao Jinghua","doi":"10.19852/j.cnki.jtcm.2025.03.019","DOIUrl":"10.19852/j.cnki.jtcm.2025.03.019","url":null,"abstract":"<p><strong>Objective: </strong>To compare the changes in gait parameters before and after the treatment of lateral ankle sprain using the rotating-pulling-poking manipulation, and explore the potential bio-mechanical mechanism of this manipulation.</p><p><strong>Methods: </strong>Forty patients with lateral ankle sprains were randomly divided into two groups in a 1:1 ratio using a random number table. The experimental group were treated by rotating-pulling-poking manipulation and elastic bandage external fixation, while the control group were treated by ice compress and elastic bandage external fixation. The treatment courses of the two groups were both 2 weeks. We used a three-dimensional motion capture system for kinematic measurements and a Bertec gait analysis force measurement system for mechanical measurements, and compared the changes in gait parameters between the two groups of patients before and after treatment.</p><p><strong>Results: </strong>Intragroup comparison showed that the support time, swing time, peak of back extension, peak of plantar flexion, peak of toe pedal force, and peak of heel landing force of the affected feet in the experimental group were significantly improved compared to those before treatment (<i>P <</i> 0.05). The swing time of the affected feet in the control group was significantly improved compared to that before treatment (<i>P <</i> 0.05). The inter group comparison showed that the gait speed, stride length, peak of back extension, peak of plantar flexion, peak of toe pedal force, and peak of heel landing force of the affected feet in the experimental group were significantly better than those in the control group (<i>P <</i> 0.05).</p><p><strong>Conclusions: </strong>The rotating-pulling-poking manipulation can effectively improve the patient's gait and range of motion of the affected ankle joint, and enhance the negative gravity in the vertical direction of the affected foot, and the braking and driving forces in the front and back directions. This may be the potential biomechanical mechanism of the rotating-pulling-poking manipulation for treating lateral ankle sprain.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 3","pages":"667-675"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prognostic model of immunoglobulin A nephropathy using artificial neural network: a retrospective study based on integrated Chinese and Western Medicine.","authors":"Chen Hongyu, Zheng Xinyi, Wang Zeng, Ding Xiaoyu, X U Luhuan, Zhu Qin","doi":"10.19852/j.cnki.jtcm.2025.03.002","DOIUrl":"10.19852/j.cnki.jtcm.2025.03.002","url":null,"abstract":"<p><strong>Objective: </strong>To establish and evaluate a prognostic model of immunoglobulin A nephropathy (IgAN) based on integrated Chinese and Western Medicine.</p><p><strong>Methods: </strong>Retrospective analysis from 1/1/2013 to 12/31/2015 was performed on 735 patients who were diagnosed with IgAN. In addition, 105 external data sets from 1/1/2016 to 12/31/2018 were used to verify the constructed model. The end point was entry into end-stage renal disease or a doubling of serum creatinine (Scr) level from baseline. Kaplan-Meier curve survival analysis and multivariable Cox regression analysis were used to find independent prognostic factors. MATLAB 2018b and artificial neural network (ANN) were used to construct prognostic risk factor prediction models each for Traditional Chinese Medicine (TCM), Western Medicine, and integrated TCM and Western Medicine. The ANN model incorporated WANG Yongjun's new five-type syndrome differentiation for IgAN. The prediction efficiencies of the three models were compared using the confusion matrix and the area under thecurve (AUC).</p><p><strong>Results: </strong>Patients from 1/1/2013 to 12/31/2015 were followed for a mean of (46 ± 19) months. The 5-year median overall renal survival time was 58.6 months, and a total of 40 patients (5.4%) entered the endpoint. Ratio of males to females was 1.48:1. Median age of patients undergoing renal puncture was 35 years. Median 24-hour urinary protein was 0.55 g and 37 patients (5.0%) had pronounced proteinuria (24-hour urine protein ≥ 3.5 g). Median serum creatinine was 76 μmol/L and mean estimated glomerular filtration rate was (90 ± 33) mL/min per 1.73 m². Oxford classification of renal pathology suggested a high rate of focal segmental glomeru-losclerosis (80.3%). Use of immunosuppressants was the most common (71.3%) treatment after renal puncture and improved clinical outcomes of IgAN. TCM differentiation of kidney deficiency was the most common syndrome (69.5%). Independent risk factors for the endpoint were male, anemia, high urinary protein, and an Oxford classification of segmental sclerosis (S). AUCs of the Western Medicine, TCM, and integrated Chinese and Western Medicine models were 0.89, 0.87, and 0.92, respectively. In external data (1/1/2016 to 12/31/2018), the performance of the three models was 0.88, 0.80, and 0.94, respectively.</p><p><strong>Conclusions: </strong>ANN can be used to successfully construct a 5-year prediction model of IgAN after renal puncture. The efficiency of this model, which combines TCM and Western Medicine factors based on Wang's new five-type syndrome differentiation, exceeds that of Western Medicine factors or TCM factors alone in data from this single-center retrospective study.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 3","pages":"676-684"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xiong's Shiwei Wendan decoction attenuates plaque lesions and balances gut microbiota dysbiosis in ApoE-/- mice with high-fat diet.","authors":"Liu Qian, Xiao Liuchen, Yuan Yue, Dang Xiaopeng, Wen Jie, Tan Moye, Liu Yuxin, G U Hongfeng, Xie Xuejiao","doi":"10.19852/j.cnki.jtcm.2025.03.008","DOIUrl":"10.19852/j.cnki.jtcm.2025.03.008","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the anti-atherosclerotic potential and gut microbiota (GM) modulation effects of Xiong's Shiwei Wendan decoction (, XSWD).</p><p><strong>Methods: </strong>For <i>in vitro</i> study, Tsuchiya human peripheral blood mononuclear cell-1 (THP-1) derived foam cells were used to examine the possible anti-atherosclerotic effect of XSWD and XSWD-medicated serum. Atherosclerosis-prone apolipoprotein E-deficient (ApoE-/-) mice were utilized for <i>in vivo</i> analysis. After an 8-week high-fat diet (HFD) adminstration, 25 male ApoE-/- mice were randomly divided into the model group, different doses of XSWD groups (1.25, 2.5, 5 mg/mL), and atorvastatin group (2.6 mg/kg). Following a continuous 8-week intervention, all mice underwent examination for AS lesion formation and assessment of its serum lipid profile. To investigate the effect on the gut microbiome, 16S rRNA gene sequencing targeting the V3-V4 hypervariable region was performed on the colonic content of mice.</p><p><strong>Results: </strong>XSWD administration attenuated lipid deposition in THP-1 cells, significantly reduced aortic plaque lesions, improved the lipid profile, and normalized GM composition in HFD-fed ApoE-/- mice.</p><p><strong>Conclusion: </strong>This study investigated the potential anti-atherosclerotic and gut microbio-ta-restoring effects of XSWD in ApoE-/- mice, with findings suggesting that XSWD may be a promising preventive measure against atherosclerosis through its ability to reduce lipid accumula-tion in foam cells, improve lipid profile, and restore gut microbiota composition.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 3","pages":"508-517"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between colorectal polyps and pulmonary nodules based on the theory of the lung and the large intestine being internally and externally connected.","authors":"Q U Tongshuo, Zhang Liping, Zhao Yuqing, Zhang Huan","doi":"10.19852/j.cnki.jtcm.2025.03.003","DOIUrl":"10.19852/j.cnki.jtcm.2025.03.003","url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationship between colorectal polyps and pulmonary nodules from the perspective of the lung and the large intestine being internally and externally connected, aiming to provide a theoretical basis for clinical diagnosis and treatment.</p><p><strong>Methods: </strong>We retrospectively analyzed the data of patients who underwent electronic colonoscopy and were found to have colorectal polyps at the Gastrointestinal Endoscopy Center of Dongfang Hospital, Beijing University of Chinese Medicine, from January 1, 2017, to December 31, 2023. We also reviewed their lung CT results and used statistical software to analyze the recurrence, location, size, and pathology of colorectal polyps in relation to the presence, number, and size of pulmonary nodules.</p><p><strong>Results: </strong>Both colorectal polyps and pulmonary nodules are more common in elderly males. Patients with recurrent colorectal polyps are more likely to have pulmonary nodules, which tend to be located in the left colon and are more likely to be adenomatous in nature; those without pulmonary nodules show no clear pattern in polyp distribution, with a tendency towards inflammatory and hyperplastic pathology; the data from this study suggests that the proportion of lung nodules larger than 0.5 cm in the recurrent group is higher than in the non-recurrent group, and the proportion of colorectal polyps larger than 1 cm in the recurrent group is also higher than in the non-recurrent group.</p><p><strong>Conclusion: </strong>There is a certain connection between the pathogenesis and treatment of colorectal polyps and pulmonary nodules. Cold, phlegm, dampness, blood stasis, and toxic coagulation are common pathogenic factors of the two diseases. Patients with larger colorectal polyps should be advised to undergo regular colonoscopy. Patients with recurrent polyps or those with left colon necrosis or cancer indicated by colonoscopy should be advised to complete lung related examinations to rule out the possibility of pulmonary nodules.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 3","pages":"685-692"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervention and mechanism of Xiaoyin Anshen Yin in treatment of psoriasis combined with sleep disorders.","authors":"Diao Ruohan, Duan Xingwu, L I Lingling, Q U Tiange, Feng Huishang, Chen Guangshan","doi":"10.19852/j.cnki.jtcm.2025.03.004","DOIUrl":"10.19852/j.cnki.jtcm.2025.03.004","url":null,"abstract":"<p><strong>Objective: </strong>To explore the therapeutic mechanisms of Xiaoyin Anshen Yin (, XYAS) in treating psoriasis associated with sleep focusing on melatonin and the regulation of the nuclear factor kappa-B (NF-κB) pathway.</p><p><strong>Methods: </strong>Forty Sprague-Dawley rats were randomly divided into four groups, and administered distilled water, XYAS and its two different disassembly prescriptions by gavage respectively. Four types of drug-containing serums corresponding to the four groups were then prepared. Tumor necrosis factor (TNF)-α stimulated HaCaT was used to establish a psoriasis cell model, and the serums and the retinoid related orphan receptor alpha (RORα) inverse agonist were used respectively to intervene in the model. Enzyme-linked immunosorbent assay was used to detect the levels of interleukin (IL)-6 and melatonin in each group; flow cytometry was used to detect the levels of reactive oxygen species (ROS), mitochondrial membrane potential, and apoptosis; Western blot was used to evaluate the levels of superoxide dismutase 2 (SOD2), cytochrome-c (Cyt-c), inhibitor of kappa-B alpha (IκBα), p65 and phosphorylated p65.</p><p><strong>Results: </strong>XYAS and its disassembly prescriptions inhibited the secretion of inflammatory factors such as IL-6, reduced the ROS content and Cyt-c expression, increased the mitochondrial membrane potential and SOD2 content, promoted the apoptosis in HaCaT cells and inhibited the activation of the NF-κB pathway. XYAS was also found increase the melatonin content. The above effects are beneficial in the treatment of psoriasis combined with sleep disorders. Meanwhile, XYAS no longer had a significant ameliorative effect after applying the RORα inverse agonist, suggesting that the therapeutic effect of XYAS is related to RORα.</p><p><strong>Conclusions: </strong>The results of this study confirm that XYAS can be utilized for the treatment of psoriasis combined with sleep disorders <i>via</i> inhibiting the NF-κB pathway, anti-inflammatory, antioxidant and pro-apoptotic, which is in part related to the regulatory role of melatonin and its receptor RORα.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 3","pages":"552-560"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of influential factors about deficiency constitution of Traditional Chinese Medicine based on multi-methods.","authors":"Luo Yue, Cheng Xiaoen, Jiang Luxia, S U Biliang, Zhao Yuxin, O U Jintao, Wen Chuanbiao","doi":"10.19852/j.cnki.jtcm.2025.03.020","DOIUrl":"10.19852/j.cnki.jtcm.2025.03.020","url":null,"abstract":"<p><strong>Objective: </strong>To find more influencing factors <i>Qi-</i>deficiency constitution of Traditional Chinese Medicine (TCM) using dynamic and comprehensive information.</p><p><strong>Methods: </strong>Because grey relational analysis (GRA) is good at processing incomplete information and has no special requirements for sample size and distribution. We acquired 2122 pieces of valid <i>Qi-</i>deficiency constitution dynamic data after preprocessing, and used GRA combing with <i>χ</i> ² test and multivariate logistic regression analysis to discover and sort the influencing factors of <i>Qi-</i>deficiency constitution.</p><p><strong>Results: </strong>For the calculation results of GRA, there were 10 (62.5%) aspects whose grey correlation degrees were greater than 0.6. The results of <i>χ</i> ² test showed that all the above 10 aspects were statistically significant with <i>Qi-</i>deficiency constitution. The analysis results of multivariate logistic regression analysis showed the following factors were positively correlated with <i>Qi-</i>deficiency constitution: premature birth, sleeping late and getting up early, sleeping late and getting up late, irregular sleeping, sleeping 6.0-6.9 h per day, artificial feeding, female, age at 18-19, and father's age at 18-19 years old when a baby at birth. The following factors were negatively correlated with <i>Qi-</i>deficiency constitution: sleeping 8.0-8.9 h per day and ≥ 9.0 h per day, and age at 30-39 and 40-49 years old.</p><p><strong>Conclusions: </strong>It is necessary to pay attention to these innate and acquired information of individuals which may lead to <i>Qi-</i>deficiency constitution. And our research also provides a novel methodological thinking for analyzing the influential factors of TCM constitution.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 3","pages":"693-701"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matrine alleviates coronary microvascular dysfunction in ischemia with non-obstructive coronary artery disease mice induced by advanced glycation end products inhibition of the reactive oxygen species-mediated endoplasmic reticulum stress in cardiac microvascular endothelial cells.","authors":"D U Haixia, Qiu Chuan, M A Yanpeng, Pan Shuo, Wang Xiqiang, Wang Junkui, Liu Zhongwei","doi":"10.19852/j.cnki.jtcm.2025.03.006","DOIUrl":"10.19852/j.cnki.jtcm.2025.03.006","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the protective effect of matrine on coronary microvascular dysfunction (CMD) induced by advanced glycation end products (AGEs) in a mouse model of ischemia with non-obstructive coronary artery disease (INOCA), with a focus on the underlying mechanisms, particularly the endoplasmic reticulum (ER) stress protein kinase R-like ER kinase (PERK)/ nuclear factor of activated T-cells (NFAT) signaling pathway.</p><p><strong>Methods: </strong>An INOCA model was established in mice, and CMD was induced by peritoneal injections of AGEs. Matrine was administered daily <i>via</i> intraperitoneal injections. Coronary microcirculation was evaluated using coronary flow velocity reserve (CFVR), and cardiac microvascular endothelial cells (CMECs) were isolated for assessment of apoptosis, inflammation, oxidative stress, and microthrombosis. Markers of ER stress and the PERK/NFAT pathway were examined through immunoblotting, immunofluorescence, and enzymatic assays. The effect of matrine were further evaluated in CMECs treated with AGEs and the PERK agonist.</p><p><strong>Results: </strong>Matrine treatment significantly improved CFVR and reduced CMD in AGEs-exposed INOCA mice. In CMECs, matrine attenuated AGEs-induced apoptosis, inflammation, and microthrombosis. It also suppressed intracellular reactive oxygen species (ROS) generation, ER stress markers, and PERK/NFAT signaling. Matrine's effects were concentration-dependent and partially reversed by the PERK agonist, confirming its action through the ER stress pathway. No significant toxicities were observed with matrine administration.</p><p><strong>Conclusion: </strong>Matrine attenuates AGEs-induced CMD in INOCA by suppressing the ROS-mediated ER stress PERK/NFAT signaling pathway in CMECs. This study highlights matrine's potential as a therapeutic agent for CMD in diabetic cardiovascular complications.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 3","pages":"473-484"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}