Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan最新文献

{"title":"Effect of add-on therapy with Traditional Chinese Medicine on the survival of patients with anemic lower-risk myelodysplastic syndromes in the real-world setting: a retrospective study.","authors":"Q U Weiying, Tan Xyucheng, Zhao Yihan, Y U Yanan, Zhao Lin","doi":"10.19852/j.cnki.jtcm.2025.01.014","DOIUrl":"10.19852/j.cnki.jtcm.2025.01.014","url":null,"abstract":"<p><strong>Objective: </strong>To illustrate the effect of add-on therapy of Traditional Chinese Medicine (TCM) on the long-term survival of anemic lower-risk myelodysplastic syndromes (LR-MDS) patients.</p><p><strong>Methods: </strong>In this study, we conducted a retrospective analysis of the data of patients with LR-MDS who were identified from Shuguang Hospital between January 2006 and June 2020. The Kaplan-Meier method was used to calculate overall survival (OS), while the Cox model was employed to analyze prognostic factors of long-term survival. A total of 162 patients who met the inclusion criteria were divided into two groups: the TCM group (<i>n =</i> 78) or the non-TCM group (<i>n =</i> 84).</p><p><strong>Results: </strong>There were no significant differences in baseline characteristics. The cumulative survival rate of the TCM group was significantly higher than that of the non-TCM group [log-rank <i>P =</i> 0.029, hazard ratio (<i>HR</i>) = 0.484, 95% confidence interval (<i>CI</i>) (0.249, 0.942), <i>P <</i> 0.05]. Patients with longer TCM treatment appeared to have better OS (≥ 12 months <i>vs</i> < 12 months); [<i>HR</i>, 0.166 95% <i>CI</i> (0.055, 0.508), <i>P <</i> 0.001)]. According to the Cox model analysis, the combination of TCM and conventional Western Medicine may be a protective factor affecting the long-term survival of LR-MDS patients [<i>HR</i> = 0.509, 95% <i>CI</i>, (0.261, 0.993), <i>P =</i> 0.048]. The hematologic improvement erythroid response (HI-E) rate of the TCM group was significantly higher than that of the non-TCM group (69.23% <i>vs</i> 52.38%; <i>P =</i> 0.028). However, the duration of HI-E and cases of disease progression after HI-E did not significantly differ from the non-TCM group (<i>P ></i> 0.05).</p><p><strong>Conclusions: </strong>The integration of TCM and Western Medicine has the potential to extend the OS of LR-MDS patients when compared to the use of Western Medicine alone.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 1","pages":"152-159"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative proteomic analysis of the brain reveals the potential antidepressant mechanism of Jiawei Danzhi Xiaoyao San in a chronic unpredictable mild stress mouse model of depression.","authors":"L I Yajing, Wang Baoying, Shao Wenxue, L U Shuaifei, S U Pan, Bai Ming, X U Erping, L I Yucheng","doi":"10.19852/j.cnki.jtcm.2025.01.003","DOIUrl":"10.19852/j.cnki.jtcm.2025.01.003","url":null,"abstract":"<p><strong>Objective: </strong>To reveal the antidepressant mechanisms of Jiawei DanZhiXiaoYaoSan (,JD) in chronic unpredictable mild stress (CUMS)-induced depression in mice.</p><p><strong>Methods: </strong>Using the CUMS mouse model of depression, the antidepressant effects of JD were assessed using the sucrose preference test (SPT), forced swimming test (FST), and tail suspension test (TST). Tandem mass tag (TMT)-based quantitative proteomic analysis of the brain was performed following JD treatment. Hierarchical clustering, Gene Ontology function annotation, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and protein-protein interactions (PPIs) were used to analyze differentially expressed proteins (DEPs), which were further validated using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting.</p><p><strong>Results: </strong>Behavioral tests confirmed the anti-depressant effects of JD, and bioinformatics analysis revealed 59 DEPs, including 33 up-regulated and 26 down-regulated proteins, between the CUMS and JD-M groups. KEGG and PPI analyses revealed that neuro-filament proteins and the Ras signaling pathway may be key targets of JD in the treatment of depression. qRT-PCR and Western blotting results demonstrated that CUMS reduced the protein expression of neurofilament light (NEFL) and medium (NEFM) and inhibited the phosphorylation of extracellular regulated kinase 1/2 (ERK1/2), whereas JD promoted the phosphorylation of ERK1/2 and up-regulated the protein expression of NEFL and NEFM.</p><p><strong>Conclusions: </strong>The antidepressant mechanism of JD may be related to the up-regulation of p-ERK1/2 and neurofilament proteins.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 1","pages":"22-31"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese patent medicine for atherosclerosis: a systematic review and Meta-analysis of randomized controlled trials.","authors":"X U Jian, Liu Yuntao, Luo Zhihao, Zhao Zhen, Wang Dawei, Liu Qing","doi":"10.19852/j.cnki.jtcm.2024.06.001","DOIUrl":"10.19852/j.cnki.jtcm.2024.06.001","url":null,"abstract":"<p><strong>Objective: </strong>To synthesize the evidence from randomized controlled trials (RCTs) to assess the efficacy and safety of Chinese patent medicine (CPM) on atherosclerosis (AS) or with a high risk of atherosclerosis.</p><p><strong>Methods: </strong>All RCTs in three databases (PubMed, EMBASE, and Cochrane Library) were included from the inception of the database to September 20, 2019. The methodological evaluation of the included trials was carried out using the Cochrane Collaboration Risk of Bias Tool. Meta-analysis was conducted using RevMan 5.3 software. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to evaluate the quality of evidence.</p><p><strong>Results: </strong>Eighteen RCTs were included, involving a total of 3885 patients with AS or with a high risk of AS. Most trials had favorable methodology. Meta-analysis suggested significant differences in clinical endpoint (<i>n =</i> 1938, <i>RR</i> 0.53; 95% <i>CI</i> 0.40 to 0.69, <i>P <</i> 0.00001; <i>I</i> ² = 0%); the change in carotid artery IMT (<i>n =</i> 1723, <i>MD</i> -0.09, 95% <i>CI</i> －0.14 to -0.04, <i>P <</i> 0.001; <i>I</i> ² = 40%); change in FMD (<i>n =</i> 239, <i>MD</i> 0.87, 95% <i>CI</i> 0.52 to 1.21, <i>P <</i> 0.00001; <i>I</i> ² = 0%); change in high sensitive C-reactive protein (hs-CRP) (<i>n =</i> 1527, <i>MD</i> －1.89, 95% <i>CI</i> －3.36 to －0.42, <i>P =</i> 0.01; <i>I</i> ² = 94%) and incidence of total adverse events (<i>RR</i> 0.76, 95% <i>CI</i> 0.62 to 0.93, <i>P =</i> 0.009; <i>I</i> ² = 40%) in favor of the experimental group. However, meta-analysis showed no significant differences in the change in low-density lipoprotein-C (LDL-C) (<i>n =</i> 2419, <i>MD</i> －0.19, 95% <i>CI</i> －0.50 to 0.12, <i>P =</i> 0.22, <i>I</i> ² = 94%) between the experimental and control groups.</p><p><strong>Conclusion: </strong>CPM could have certain clinical efficacy in the treatment of AS. However, more double-blinded placebo-controlled RCTs are required in further evaluations to provide stronger evidence.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1082-1090"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome sequencing-based study on the mechanism of action of Jintiange capsules in regulating synovial mesenchymal stem cells exosomal miRNA and articular chondrocytes mRNA for the treatment of osteoarthritis.","authors":"Chen Zhongying, Zhang Xue, Zhang Xiaofei, Zou Junbo, Yuan Puwei, Shi Yajun","doi":"10.19852/j.cnki.jtcm.20240927.004","DOIUrl":"10.19852/j.cnki.jtcm.20240927.004","url":null,"abstract":"<p><strong>Objective: </strong>To corroborate the efficacy of Jintiange capsules (JTGs) in the treatment of osteoarthritis (OA) by exploring the potential mechanism of action of synovial mesenchymal stem cell exosomes (SMSC-Exos) and articular chondrocytes (ACs) through transcriptome sequencing (RNA-seq).</p><p><strong>Methods: </strong>Type II collagenase was used to induce OA in rats. The efficacy of JTGs was confirmed by macroscopic observation of articular cartilage, micro-CT observation, and safranin fast green staining. After SMSC-Exos and ACs were qualified, RNA-seq was used to screen differentially expressed miRNAs and mRNAs. The target genes of differentially expressed miRNAs in Synovial mesenchymal stem cells (SMSCs) were predicted based on the multiMiR R package. The co-differentially expressed genes of SMSC-Exos and ACs were obtained by venny 2.1.0. The miRNA-mRNA regulatory network was constructed by Cytoscape software. Based on the OmicShare platform, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis was performed on the mRNA regulated by key miRNAs. Expression trend analysis was performed for co-differentially expressed genes. Correlation analysis was performed on micro-CT efficacy indicators, co-differentially expressed genes mRNA and miRNA.</p><p><strong>Results: </strong>The efficacy of each administration group of JTGs was significant compared with the model group. SMSC-Exos and ACs were identified by their characteristics. The expression of rno-miR-23a-3p, rno-miR-342-3p, rno-miR-146b-5p, rno-miR-501-3p, rno-miR-214-3p was down-regulated in OA pathological state, and the expression of rno-miR-222-3p, rno-miR-30e-3p, rno-miR-676, and rno-miR-192-5p expression was up-regulated, and the expression of all these miRNAs was reversed after the intervention with JTGs containing serum. The co-differentially expressed genes were enriched in the interleukin 17 signaling pathway, tumor necrosis factor signaling pathway, transforming growth factor-β signaling pathway, etc. The expression trends of Ccl7, Akap12, Grem2, Egln3, Arhgdib, Ccl20, Mmp12, Pla2g2a, and Nr4a1 were significant. There was a correlation between micro-CT pharmacodynamic index, mRNA, and miRNA.</p><p><strong>Conclusion: </strong>JTGs can improve the degeneration of joint cartilage and achieve the purpose of cartilage protection, which can be used for the treatment of OA. SMSCs-related miRNA expression profiles were significantly altered after the intervention with JTGs containing serum. The 9 co-differentially expressed genes may be the key targets for the efficacy of JTGs in the treatment of OA rats, which can be used for subsequent validation.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1153-1167"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weichang' an pill alleviates functional dyspepsia through modulating brain-gut peptides and gut microbiota.","authors":"Liao Mengting, L I Tao, Chu Fuhao, Chen Yan, Lou Ni, Zhuang Yuan, B O Rongqiang, Ding Xia","doi":"10.19852/j.cnki.jtcm.2024.06.006","DOIUrl":"10.19852/j.cnki.jtcm.2024.06.006","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of Weichang'an pill (, WCAP) on functional dyspepsia (FD) and explore its regulation of brain-gut peptides (BGPs) and gut microbiota balance as a potential treatment mechanism.</p><p><strong>Methods: </strong>The \"0 ℃ saline gavage + irregular feeding and tail clamp\" method was used to establish the FD rat model, excluding the normal group. The successfully established FD rat models were randomly divided into the model group and the WCAP1 (WC1), WCAP2 (WC2), WCAP3 (WC3), WCAP4 (WC4), WCAP5 (WC5), and Domperidone (Dom) groups (<i>n =</i> 10 per group). The unhandled rats were designated as the control group. The gastrointestinal motility of the rats was evaluated using the charcoal propulsion test. Histopathology was assessed by hematoxylin and eosin (HE) staining. The enzyme-linked immunosorbnent assay method was used to detect the levels of motilin (MTL), gastrin (GAS), vasoactive intestinal peptide (VIP), and somatostatin (SS) in the serum from each group. In addition, the gut microbiota composition of fecal samples was analyzed using 16S rRNA sequencing.</p><p><strong>Results: </strong>Rat models were successfully established according to data from rat state, gastrointestinal motility assessments, and HE staining. WCAP improved FD symptoms by accelerating the gastric emptying and small intestinal transit of FD rats. Mechanistically, WCAP increased the levels of GAS and MTL and reduced the levels of VIP and SS. Moreover, WCAP treatment restored the total relative abundance of Firmicutes and Bacteroidetes, increased the species richness of the gut flora, and modulated the changes in the composition and function of the gut microbiota.</p><p><strong>Conclusion: </strong>WCAP can effectively promote the recovery of gastrointestinal motility disorders in FD rats. The mechanism may be related to regulating the secretion of BGPs and the composition of the gut microbiota.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1177-1186"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A neural regulation mechanism of head electroacupuncture on brain network of patients with stroke related sleep disorders.","authors":"Zhang Boyang, Zhou Yang, Feng Liyuan, Sui Dan, H E Lei, Tong Dan, Wang Ruoyu, Sui Xue, Song Jing, Wang Dongyan","doi":"10.19852/j.cnki.jtcm.2024.06.011","DOIUrl":"10.19852/j.cnki.jtcm.2024.06.011","url":null,"abstract":"<p><strong>Objective: </strong>To analyze part of the mechanism of electroacupuncture on Sishencong (EX-HN1) for stroke-related sleep disorders (SSD) and post-stroke cognitive impairment (PSCI).</p><p><strong>Methods: </strong>Using a randomized controlled trial (RCT) design, 72 patients were assigned to the electro-acupuncture (EA) group or the sham acupuncture (SA) group. A healthy control (HC) group was also included. Both groups were given routine rehabilitation treatment. Then, patients in the EA group were given additional electroacupuncture at Sishencong (EX_HN1). Meanwhile, patients in the SA group were given a flat-head needle sham/placebo treatment placed at the bilateral Jianyu (LI15) and Binao (LI14) line midpoints and the Jianyu (LI15) and Jianzhen (SI9) line midpoints. Before and after treatment, scales were collected and analyzed. In the second phase of the study, some subjects from the EA group were selected for functional magnetic resonance imaging (fMRI) data acquisition and comparative analysis with the HC group using a non-RCT design.</p><p><strong>Results: </strong>The EA group performed better than the SA group on the Pittsburgh sleep quality index (PSQI), Montreal cognitive assessment basic (MoCA_B), self-rating anxiety scale (SAS), and self-rating depression scale (SDS). Analysis of the fMRI showed that low-frequency (2 Hz) electroacupuncture stimulation at Sishencong (EX_HN1) can restrain frontal sup medial right (SFGmed.R), precuneus right (PCUN.R), and posterior cingulate cortex right (PCC.R) and enhance angular left (ANG.L), parietal inf left (IPL.L) and occipital mid left (MOG.L). The functional connectivity (FC) of SFGmed.R was positively correlated with PSQI. Electroacupuncture stimulation at Sishencong (EX_HN1) can reduce the side efficiency of the whole brain connection with the Thalamus.L, Hippocampus.L, and Occipital.Mid.L.</p><p><strong>Conclusions: </strong>Low frequency (2 Hz) electroacupuncture stimulation at Sishencong (EX_HN1) can simultaneously improve sleep quality, negative emotions, and cognitive functions, the first two of which may be related to SFGmed.R restraint. Electroacupuncture can make some brain areas approach the physiological bias state, which is characterized by dominant hemispheric enhancement and non-dominant hemispheric weakening. The reduced whole brain connection side efficiency with some key nodes of the brain net may relate to sleep quality improvements in SSD patients.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1268-1276"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the scientific connotation of compatibility of Chinese medicine medica based on self-assembly technology.","authors":"Dong Yingying, Guo Qin, Gao Yuan, Wang Huanhuan, Bai Dong","doi":"10.19852/j.cnki.jtcm.2024.06.013","DOIUrl":"10.19852/j.cnki.jtcm.2024.06.013","url":null,"abstract":"<p><p>Chinese materia medica (CMM) compatibility is one core content in the theory of Traditional Chinese Medicine (TCM), and elaborating the scientific connotation of CMM compatibility is of great significance to promote the modernization of TCM. Self-assembly is the combination of active ingredients into aggregates through non-covalent bonds, such as hydrogen bonding, electrostatic interactions, ionic interactions, and hydrophobic interactions. The complex properties and special structures of CMM components create the basis for self-assembly. The self-assembled materials formed after CMM compatibility is an important part of the material basis for the efficacy of TCM, which can help explain the scientific connotations of CMM compatibility. This review summarizes the self-assembly phenomenon from the perspective of drug pair combinations in recent decades and explains the scientific connotation of CMM compatibility about the material basis, pharmacodynamic changes, and mechanism of action, providing new ideas and methods for the study of TCM.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1288-1295"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bailing capsule alleviates autoimmune thyroiditis regulating peroxisome proliferator-activated receptor signaling pathway: a multi-omics analysis.","authors":"Wang Qixin, X U Liting, W U Jiangpeng, H E Xueling, Tang Huan, Cheng Guangqing, L U Tianming, Dai Chuanhao, Guo Qiuyan, Wang Jigang","doi":"10.19852/j.cnki.jtcm.20240409.001","DOIUrl":"10.19852/j.cnki.jtcm.20240409.001","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the efficacy and potential mechanism of Bailing capsule (, BL) anti-autoimmune thyroiditis (AIT).</p><p><strong>Methods: </strong>Based on the AIT rat model, the effect of BL in alleviating AIT was evaluated by detecting serum thyroid index free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroglobulin antibody (TGAb), thyroid peroxidase antibody (TPOAb), and inflammatory factors Interferon-gamma (IFN-γ), Interleukin-4, -10, and -12 (IL-4, IL-10, and IL-12) as well as thyroid tissue Hematoxylin-eosin (HE) staining and ultrastructure observation. The mechanism of BL was explored by combining transcriptome and proteome analysis, and further verified by Western blot (WB).</p><p><strong>Results: </strong>BL effectively reduced serum FT3, FT4, TGAb, and TPOAb levels in AIT rats, restored TSH balance, inhibited the release of pro-inflammatory cytokines IFN-γ and IL-12, promoted the production of anti-inflammatory cytokines IL-4 and IL-10, and significantly reduced IFN-γ/IL-4 and IL-12/IL-10, improved thyroid follicular structure, and protected thyroid tissue from injury. Kyoto Encyclopedia of Genes and Genomes and protein interaction network analysis showed that BL affected the expression of fatty acid-binding protein 4, acyl-CoA synthetase long-chain family member 1, and acyl-CoA dehydrogenase long chain to regulate the peroxisome proliferator-activated receptor signaling pathway, thereby inhibiting the fatty acid metabolism and the inflammatory state of AIT rats.</p><p><strong>Conclusions: </strong>BL could effectively reduce thyroid inflammation in AIT model rats. The possible BL mechanism was to regulate the peroxisome proliferator-activated receptor signaling pathway and inhibit fatty acid metabolism. This study suggested that BL has the potential to be used in clinical treatment of AIT.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1217-1226"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bushen Huoxue decoction improves the reproduction of endometriosis-associated infertility by regulating Homeobox A10 and αlpha(v)beta(3) integrin expression.","authors":"Tang Weiwei, Liu Kaili, Fan Xumei, Zhu Li, Zeng Zheng, Sun Jiali, Shi Jie, Zhang Zhenzhen, Gui Tao, Wan Guiping","doi":"10.19852/j.cnki.jtcm.2024.06.004","DOIUrl":"10.19852/j.cnki.jtcm.2024.06.004","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the mechanism of Bushen Huoxue decoction (, BSHXD) to treat endometriosis-induced infertility.</p><p><strong>Medhods: </strong>The main compounds of BSHXD were determined by high performance liquid chromatography-mass spectrometry (HPLC-MS/MS). The effect of BSHXD on Homeobox A10 (HOXA10) and alpha(v)beta(3) (αvβ3) integrin expression of Ishikawa cells, mouse model, and endometriosis-associated infertility women was evaluated by using Western blot analysis, immunohistochemistry and Real-Time quantitative polymerase chain reaction (RT-qPCR). The efficacy of BSHXD on embryo attachment were examined by using the BeWo spheroid and mouse embryo attachment assay. HOXA10 concentration in uterine flushing fluid of endometriosis-associated infertility women treated with BSHXD was measured by Enzyme-Linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>BSHXD improved BeWo spheroid and mice blastocysts attachment to Ishikawa cells and increased embryo implantation rates in mice and pregnancy rates in women with endometriosis-associated infertility. BSHXD enhanced HOXA10 and αvβ3 integrin expression in Ishikawa cell, endometriosis mouse model, and endometriosis-associated infertility women, which potentially improved endometrial receptivity.</p><p><strong>Conclusions: </strong>BSHXD could improve endometrial receptivity of endometriosis-associated infertility in a dose-dependent manner by regulating HOXA10 and αvβ3 integrin expression.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1137-1145"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renshen (Radix Ginseng) polysaccharide promotes repair of the mice intestinal mucosa through regulatory mechanisms based on polyamine and human antigen R.","authors":"Wang Guanyu, Dai Xingzhen, Liu Yiting, Zhu Zeming, H U Ling, L I Ruliu","doi":"10.19852/j.cnki.jtcm.2024.06.003","DOIUrl":"10.19852/j.cnki.jtcm.2024.06.003","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the mechanism and effect of Renshen (<i>Radix Ginseng</i>) polysaccharide on the migration of intestinal epithelial cell line 6 (IEC-6), as well as the repair mechanism of Renshen (<i>Radix Ginseng</i>) polysaccharide on colonic injury induced by dextran sulfate sodium (DSS) in mice.</p><p><strong>Methods: </strong>Mice were fed 3% (w/v) DSS for 6 d to create colonic lesions. A cell-migration model was created using cell scratching. mRNA expression, protein expression, translation efficiency of mRNA, and nucleoplasmic distribution of human antigen R (HuR) were determined by real-time reverse transcription-quantitative polymerase chain reaction, western blotting, a dual luciferase reporter system, and immunofluorescence staining, respectively.</p><p><strong>Results: </strong>Renshen (<i>Radix Ginseng</i>) polysaccharide promoted the migration of IEC-6 cells and affected expression of stromal interaction molecule 1 (STIM1) and cell division cycle 42 (Cdc42) at transcriptional and post-transcriptional levels.</p><p><strong>Conclusions: </strong>Renshen (<i>Radix Ginseng</i>) polysaccharide-induced repair of intestinal mucosal injury may be mediated by increased cell migration <i>via</i> polyamine-based regulatory mechanisms. <i>In vitro</i> and <i>in vivo</i> experiments suggest that Renshen (<i>Radix Ginseng</i>) polysaccharide-induced post-transcriptional regulation of STIM1 and Cdc42 may be related to differences in the regulation of different target genes by HuR. Taken together, these data provide a reference for further exploration of the protective effect of Renshen (<i>Radix Ginseng</i>) on the intestinal mucosa.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1118-1126"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}