Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan最新文献

{"title":"Regulation of mild moxibustion on non-neuronal cholinergic system in ulcerative colitis rats.","authors":"Peng Guangbin, L I Han, Zhu Lu, Q I Qin, Zheng Shiyu, Zhang Linshan, Lin Yaying, M A Zhe, W U Luyi, Huang Yan, W U Huangan","doi":"10.19852/j.cnki.jtcm.2025.02.013","DOIUrl":"10.19852/j.cnki.jtcm.2025.02.013","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect and mechanism of mild moxibustion on the non-neuronal cholinergic system (NNCS) in rats with ulcerative colitis (UC).</p><p><strong>Methods: </strong>UC rat model was established by administering 4% dextran sulfate sodium. After 7 d, mild moxibustion, α7 nicotinic acetylcholine receptors (α7nAchRs) antagonist (α-bungarotoxin, α-BGT), vesicular acetylcholine transport inhibitor (vesamicol hydrochloride, VH) and organic cation transporters inhibitor (quinine, Qu) treatments were performed once daily for 7 d. Haematoxylin and eosin staining was used for morphological evaluation of colon tissues. Enzyme-linked immunosorbent assay (ELISA) was used to measure the protein expressions of interleukin-1β (IL-1β) and choline acetyltransferase (ChAT) in colon tissue. Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) was used to detect the mRNA expressions of IL-1β, carnosine acetyltransferase (CarAT), ChAT, and nuclear factor kappa-B p65 subunit (NF-κB p65) in colon tissue. Western blot was used to detect NF-κB p65 protein expression in colon tissue. Immunofluorescence was used to detect the expressions of neuronal acetylcholine (nAch) and non-neuronal acetylcholine (nnAch, released by NNCS) in colon tissue.</p><p><strong>Results: </strong>Mild moxibustion inhibited colon inflammation and repaired mucosal damage to the colon in UC rats. Meanwhile, mild moxibustion could downregulate the expressions of IL-1β, NF-κB p65 protein and mRNA (<i>P</i> < 0.01), and upregulate the expressions of ChAT protein and CarAT mRNA (<i>P</i> < 0.05, <i>P</i> < 0.01). The α7nAChR antagonist α-BGT can reverse the protective effect of mild moxibustion on the UC and the inhibitory effect on the inflammatory factors. VH cannot affect the effect of mild moxibustion on the expressions of IL-1β and nnAch, while Qu can reverse the effect of mild moxibustion on the expression of IL-1β and nnAch.</p><p><strong>Conclusions: </strong>Mild moxibustion can inhibite colon inflammation in UC rats, which is closely related to the release of acetylcholine by NNCS and its mediated mechanism of cholinergic anti-inflammation pathway.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 2","pages":"368-375"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of acupuncture on brain activity in patients with decreasing ovarian reserve: a resting-state functional magnetic resonance imaging study.","authors":"Bai Tianyu, Yang Jiaen, Yin Liang, L I Jinling, Liu Jianxian, L I Zongchang, Sun Zeming, Jia Ning, X U Chengchao","doi":"10.19852/j.cnki.jtcm.2025.02.011","DOIUrl":"10.19852/j.cnki.jtcm.2025.02.011","url":null,"abstract":"<p><strong>Objective: </strong>To examine the variations in brain regions among individuals with decreasing ovarian reserve (DOR) compared to healthy controls using resting-state functional magnetic resonance imaging (rs-fMRI), and to assess the immediate effects of acupuncture stimulation on these brain regions in DOR patients.</p><p><strong>Methods: </strong>Twenty patients diagnosed with DOR (DOR group) and twenty healthy controls (HC group) who underwent rs-fMRI scans were included. The DOR group received acupuncture and underwent a subsequent rs-fMRI scan. Amplitude of low-frequency fluctuations (ALFF) analysis was utilized to identify disparities in brain regions between DOR and HC groups, and to evaluate the immediate effects of acupuncture on DOR patients' brain regions. Common brain regions were identified as seed points for functional connectivity (FC) analysis.</p><p><strong>Results: </strong>In this study, a total of 20 HCs and 20 patients with DOR were initially enrolled. However, due to incomplete personal information, three participants were removed from the HC group. Additionally, two DOR patients experienced symptoms such as physical discomfort and shortness of breath during the MRI scan, leading to their exclusion due to excessive head movement parameters. Consequently, 17 HCs and 16 DOR patients completed the entire study protocol. Comparative analysis revealed that DOR patients exhibited increased ALFF values in the left inferior temporal gyrus (ITG) and middle temporal gyrus (MTG), while ALFF values in the bilateral superior frontal gyrus (SFG), middle frontal gyrus (MFG), and left inferior frontal gyrus (IFG) were decreased compared to HCs. Following acupuncture intervention, ALFF values in the left SFG, MFG, and supplementary motor area (SMA) of DOR patients increased. Furthermore, functional connectivity (FC) analysis demonstrated increased connectivity of the left SFG with the bilateral calcarine sulcus and lingual gyrus post-acupuncture.</p><p><strong>Conclusion: </strong>This study highlights abnormal neural activity in the SFG, MFG, IFG, and ACC in DOR patients compared to HCs. Acupuncture was found to regulate the activity of the SFG, bringing it closer to normal levels, and enhancing its functional connectivity with the bilateral calcarine sulcus and lingual gyrus.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 2","pages":"450-457"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Jiedu formula as adjuvant therapy for early recurrence of hepatocellular carcinoma after radical surgery: a propensity score matching study.","authors":"Feng Qiuting, H U Jiajia, Y U Song, Zhu Huirong, Cheng Simo, Zhai Xiaofeng","doi":"10.19852/j.cnki.jtcm.2025.02.019","DOIUrl":"10.19852/j.cnki.jtcm.2025.02.019","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical efficacy of using a Jiedu formula as an adjunctive therapy in patients with hepatocellular carcinoma (HCC) after hepatectomy.</p><p><strong>Methods: </strong>In total, 354 patients were included in this study. All patients were categorized into the traditional herbal medicine (THM) group (<i>n =</i>115) or the non-THM treatment (nTHM) group (<i>n =</i>239), with the Jiedu formula administered twice a day to the patients in the THM group. The primary outcome was recurrence-free survival (RFS). Univariate and multivariate Cox regression analyses were performed to identify the prognostic factors associated with RFS. Then, the high risk of recurrence among patients was identified, and propensity score matching (PSM) and RFS analysis were performed to analyze the prognostic factors for the outcomes of patients at a high risk of recurrence in different groups.</p><p><strong>Results: </strong>The one, two, three, and five-year RFS rates of the THM and nTHM groups were 76.4% <i>vs</i>66.1%, 65.5% <i>vs</i>48.8%, 57.9% <i>vs</i>39.9%, and 43.9% <i>vs</i>29.2%, respectively. The results of the Multivariate Cox analysis showed that giant tumors [hazard ratio (<i>HR</i>), 1.54, <i>P =</i> 0.04], poor degree of differentiation, microsatellite, or microvascular invasion (<i>HR</i>, 1.29, <i>P</i>= 0.09) increased the risk of recurrence. In the population with a high risk of recurrence, after PSM, the one, two, three, and five-year survival rates were 70.6% <i>vs</i>68.0%, 63.0% <i>vs</i>43.1%, 59.6% <i>vs</i>33.3%, and 41.9% <i>vs</i>26.4%, respectively.</p><p><strong>Conclusion: </strong>In this study, THM was found to be an effective agent for adjuvant therapy for HCC to prevent early recurrence of HCC after hepatic resection.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 2","pages":"443-449"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yishen Tongluo formula ameliorates kidney injury modulating inflammation and apoptosis in streptozotocin-induced diabetic kidney disease mice.","authors":"Yuan Jiayao, W U Suhui, Meng Yufan, L I Hanbing, L I Genlin, X U Jiangyan","doi":"10.19852/j.cnki.jtcm.2025.02.007","DOIUrl":"10.19852/j.cnki.jtcm.2025.02.007","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect and mechanism of Yishen Tongluo formula (, YSTLF) in streptozotocin-induced diabetic kidney disease mice (DKD) mice.</p><p><strong>Methods: </strong>Thirty Institute of Cancer Research mice (specific pathogen free, SPF grade) were divided into five groups (<i>n</i> = 6 per group): control, DKD model, DKD model with YSTLF (4.9 g/kg), DKD model with YSTLF (9.8 g/kg), and DKD model with captopril. DKD was induced through a single intraperitoneal injection of streptozotocin (150 mg/kg). Body weight, fasting blood glucose and urine C-peptide levels were measured to assess metabolic regulation by YSTLF. Renal function was evaluated using indicators of glomerular and tubular health. Liver function was assessed by measuring aspartate aminotransferase and alanine aminotransferase levels. Renal pathological changes were examined using hematoxylin/eosin staining and transmission electron microscopy. Inflammatory and apoptosis-related factors were analyzed through enzyme-linked immunosorbent assay, immunohistochemistry, and Western blot analysis.</p><p><strong>Results: </strong>In DKD mice, fasting blood glucose, C-peptide, 24-hour urine protein (UP) levels, and renal damage were elevated, accompanied by increased inflammation and apoptosis. YSTLF significantly reduced 24-hour UP and C-peptide levels and improved kidney and liver function in DKD mice. YSTLF also mitigated glomerular hypertrophy, basement membrane thickening, and podocyte foot process effacement. It upregulated the expression of the podocyte marker podocalyxin. Furthermore, YSTLF alleviated inflammation and apoptosis, likely by reducing the overexpression of monocyte chemoattractant protein (MCP-1), Bax, and Caspase-3 in the kidneys of DKD mice.</p><p><strong>Conclusions: </strong>These findings suggest that YSTLF ameliorates kidney injury by modulating the expression of inflammatory cytokine MCP-1 and the Bax/Caspase-3 apoptosis pathway, providing a potential therapeutic approach for DKD.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 2","pages":"254-265"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Qingwei Zhitong pellets-containing quadruple therapy for eradication: a prospective, single-center, randomized trial.","authors":"Cheng Jianping, Fan Chanjuan, Zhai Lili, Wang Hui, Xie Dongling, Cai Yong, L I Zhen, Huang Kun, Bai Qixuan","doi":"10.19852/j.cnki.jtcm.2025.02.021","DOIUrl":"10.19852/j.cnki.jtcm.2025.02.021","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of 14-day Qingwei Zhitong pellets (, QZ)-containing quadruple therapy (QZQT) compared to bismuth-containing quadruple therapy (BQT) in treatment-naive patients with <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection.</p><p><strong>Methods: </strong>This single-center, randomized controlled clinical trial enrolled 333 patients, who were divided into either the QZQT group (QZ pellets, 3.2 g, three times daily; rabeprazole, 10 mg, twice daily; amoxicillin 1000 mg, twice daily; clarithromycin, 500 mg, twice daily) or the BQT group (bismuth potassium citrate, 1000 mg, three times daily; rabeprazole, 10 mg, twice daily; amoxicillin, 1000 mg, twice daily; clarithromycin, 500 mg, twice daily) for 14 d. The 13C-urea breath test assessed eradication success at least four weeks after treatment. The primary outcome focused on the eradication rate, with secondary outcomes including safety and patient compliance.</p><p><strong>Results: </strong>From August 2022 to June 2023, 342 subjects were screened, and 333 were randomized. The QZQT and BQT groups showed eradication rates of 68.9% and 67.8% (<i>P =</i> 0.838) by intention-to-treat (ITT) analysis, respectively, and 71.1% and 68.3% (<i>P =</i> 0.612) by per-protocol (PP) analysis, respectively. QZQT was non-inferior to BQT in both ITT and PP analyses. QZQT was associated with fewer side effects (57.8% of patients) than BQT (90.4%) (<i>P <</i> 0.001).</p><p><strong>Conclusion: </strong>The 14 d QZQT treatment demonstrates equal efficacy in eradicating H. pylori infection and improved patient compliance and safety compared to BQT. These results provide evidence supporting 14-day QZQT as an acceptable treatment for <i>H. pylori</i>infection.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 2","pages":"430-436"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rech. f. & Esfand as adjunctive therapy for eradication: a randomized controlled trial.","authors":"Nima Vaziri, Gholamreza Dehghannoudeh, Fariba Sharififar, Fatemeh Dabaghzadeh, Farhad Sarafzadeh, Bizhan Ahmadi","doi":"10.19852/j.cnki.jtcm.2025.02.009","DOIUrl":"10.19852/j.cnki.jtcm.2025.02.009","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of this plant as adjunctive therapy on <i>Helicobacter pylori</i> (<i>H. pylori</i>) eradication.</p><p><strong>Methods: </strong>The plant capsules were prepared and their physicochemical properties were assessed. In this clinical trial, 99 patients with <i>H. pylori</i> infection were randomized to receive <i>Salvia mirzayanii</i> Rech. f. & Esfand (<i>S. mirzayanii</i>) or placebo capsules for two weeks. All the patients in both groups received clarithromycin-based triple therapy. Both intention to treat and per protocol analyses were performed. Eradication rates, treatment side effects, and medication compliance were evaluated in both groups.</p><p><strong>Results: </strong>H. pylori eradication rate of all the randomized participants was 59.59%. The eradication rate of <i>H. pylori</i>was significantly higher in <i>S. mirzayanii</i> group compared with that in the placebo group for per protocol analysis (84.62%, <i>P</i> = 0.026) but not for intention to treat one (65.31%, <i>P =</i> 0.252). There were no significant differences between the two groups regarding the frequencies of the medications side effects and the patients with poor compliance.</p><p><strong>Conclusion: </strong>The use of <i>S. mirzayanii</i> as adjunctive therapy to 14-day clarithromycin-based triple therapy might improve <i>H. pylori</i>eradication rate.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 2","pages":"437-442"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture alleviates zymosan-induced colorectal hypersensitivity.","authors":"L I Siting, Wang Shaojun, Yin Yehui, D E Gejing, L I Caicai, Wang Ziyan, Cao Wenjie","doi":"10.19852/j.cnki.jtcm.20220425.001","DOIUrl":"10.19852/j.cnki.jtcm.20220425.001","url":null,"abstract":"<p><strong>Objective: </strong>this study to investigate the mechanism underlying the electroacupuncture (EA) alleviates colorectal hypersensitivity, a feature of irritable bowel syndrome (IBS).</p><p><strong>Methods: </strong>The colorectal hypersensitivity model was established by treating mice with zymosan. Electrophysiological techniques, Western blotting and immunofluorescence staining were used to detect the changes of the sensitive state of the colorectum and the response in spinal ganglion and spinal cord after acupuncture intervention.</p><p><strong>Results: </strong>colorectal distension studies revealed that repetitive applied electroacupuncture treatment on mice could significant alleviates colorectal intensity. Western blotting studies with nerve growth factor (NGF) in the colorectum, substance P (SP) in the spinal ganglion, protein kinase C gamma (PKCγ) in the spinal cord, and transient receptor potential vanilloid 1 (TRPV1) showed that electroacupuncture suppressed zymosan-induced expression of TRPV1, NGF and SP in multiple tissues. Immunofluorescence labeling results showed that EA attenuated the expression of NGF in the colorectum, SP in the spinal ganglion, PKCγ in the spinal cord, and TRPV1 in all three tissues in zymosan-treated mice. Moreover, the number of neurons double-positive for TRPV1/Isolectin B4 (IB4) and TRPV1/Neurofilament (NF) 200 was increased in the spinal ganglion.</p><p><strong>Conclusion: </strong>these results provide molecular-level evidence that EA alleviates zymosan-induced colorectal hypersensitivity by altering the expression of pain-associated proteins in the colorectum and spinal cord. EA has a potential to be therapeutic intervention option for IBS treatment.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 1","pages":"32-38"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yunpiqiangshen gel improves quality of life in dialysis patients.","authors":"Y U Manshu, Jiang Chunchun, Yao Min, Hua Jianwu, Jiang Yan, Huang Min, Liu Jianjing, Zhou Yan, Wang Yuan, Sheng Meixiao","doi":"10.19852/j.cnki.jtcm.2025.01.011","DOIUrl":"10.19852/j.cnki.jtcm.2025.01.011","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of Yunpiqiangshen gel which composed of eleven herbs on quality of life (QOL) improvement.</p><p><strong>Methods: </strong>We enrolled 180 patients lasted from January 2020 to December 2021. Seventy-eight patients received standards of care (control group) and 76 patients received Yunpiqiangshen gel [Traditional Chinese Medicine, (TCM) group] for 6 months in statistical analysis. The primary outcome assessed using Kidney Disease Quality of Life Short Form Questionnaire version 1.3 (KDQOL-SF^TM 1.3), including Short Form Health Survey (SF-36) and Kidney Disease Targeted Areas (KDTA) scores. The second outcomes included the TCM syndrome score, Fatigue Assessment Instrument (FAI) score, Modified Quantitative Subjective Global Assessment (MQSGA) score, anthropometric indicators, and blood chemical testing. Adverse events, including decompensated gastrointestinal symptoms, were evaluated.</p><p><strong>Results: </strong>The results showed that the mean change of SF-36 (75 <i>±</i> 13 <i>vs</i> 64 <i>±</i> 16, <i>F =</i> 6.070, <i>P =</i> 0.015) and KDTA (76 <i>±</i> 7 <i>vs</i> 70 <i>±</i> 9, <i>F =</i> 4.118, <i>P =</i> 0.044) scores in the TCM group had an improvement (increase) from baseline, as compared with the control group. Yunpiqiangshen gel also resulted in a significant improvement in almost dimensions of QOL. At the end of follow-up, the imputed percentage of patients in the response rate of TCM syndrome was greater in the TCM group than in the control group (76.32% <i>vs</i> 20.51%, <i>χ</i> ² = 48.02, <i>P =</i> 0.000). The fatigue, soreness of waist, anorexia, abdominal distension, loose stool, and constipation were alleviated after Yunpiqiangshen gel therapy. The FAI (98.58 <i>±</i> 25.08 <i>vs</i> 131.21 <i>±</i> 31.85, <i>F =</i> 8.745, <i>P =</i> 0.004) and MQSGA (10.13 <i>±</i> 2.84 <i>vs</i> 12.83 <i>±</i> 3.85, <i>F =</i> 11.396, <i>P =</i> 0.001) scores in the TCM group had an improvement (reduce) from baseline compared with the control group. A higher level of albumin of patients in the TCM group compared with the control group. Diarrhea, vomit, and loose stool were more common in the TCM group, but generally mild in severity.</p><p><strong>Conclusion: </strong>Compared with the standards of care, added Yunpiqiangshen gel was a safe and effective therapy for improving QOL in dialysis patients.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 1","pages":"123-131"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of lappaconitine on Freund's complete adjuvant-induced arthritis exerted through P2X7 receptor-mediated regulation of M1/M2 balance in rats.","authors":"Zhang Pengqiang, Feng Qi, Huang Weiyan, O U Shan","doi":"10.19852/j.cnki.jtcm.2025.01.004","DOIUrl":"10.19852/j.cnki.jtcm.2025.01.004","url":null,"abstract":"<p><strong>Objective: </strong>to investigate the anti-arthritic effects of lappaconitine (LA) on adjuvant-induced arthritis in Sprague-Dawley rats and its possible involvement in the regulation of M1/M2 macrophage balance through the P2X7 receptor (P2X7r).</p><p><strong>Methods: </strong>Rats were immunized with complete Freund's adjuvant and then intraperitoneally administered LA (2, 4, or 8 mg·kg^-1·d^-1) or methotrexate (0.5 mg/kg per 3 d) for 14 d. The anti-arthritic effects of LA were evaluated through arthritis index (AI) assessment, ankle diameter measurement, and histopathological staining analysis. The analgesic effect of LA on arthritis was measured using mechanical withdrawal threshold testing and gait scoring. The impacts of LA on macrophage polarization, the expression of pro-/anti-inflammatory cytokines and P2X7r were analyzed using quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and Western blotting.</p><p><strong>Results: </strong>LA treatment significantly reduced AI scores, paw swelling, joint destruction, and inflammatory cell infiltration, and alleviated arthritis pain. Additionally, LA promoted a balanced M1/M2 ratio by increasing the mRNA expression level of M2 marker arginase 1 and decreasing those of M1 markers inducible nitric oxide synthase and interleukin (IL)-1β in synovial tissues. Furthermore, LA lowered the levels of three M1-related cytokines, namely tumor necrosis factor-α, IL-1β and IL-18, and raised the level of the M2-related cytokine IL-10. Further research showed that treatment with LA inhibited the expression of P2X7r.</p><p><strong>Conclusion: </strong>Our findings indicate that the notable therapeutic and analgesic effects of LA on AIA rats are exerted through balancing the M1/M2 ratio, probably via P2X7r.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 1","pages":"39-48"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical observation of efficacy in adhesive intestinal obstruction with Integrated Chinese (Chaihu Shugan San, ) and Western Medicine: a randomized controlled trial.","authors":"Zhang Xin, Cao Jia, Luo Chengping, Fan Yibin, D U Jie","doi":"10.19852/j.cnki.jtcm.2025.01.010","DOIUrl":"10.19852/j.cnki.jtcm.2025.01.010","url":null,"abstract":"<p><strong>Objective: </strong>To explore the treatment efficacy of integrated Chinese medicine (Chaihu Shugan San, , CSS) and western therapy in the treatment of adhesive intestinal obstruction (AIO), to provide new ideas for the management of the disease.</p><p><strong>Methods: </strong>In our single-blind randomized controlled study, 120 patients with AIO who were hospitalized in The Affiliated Hospital of China West Normal University Nan Chong Gaoping District People's Hospital from January 2021 to June 2022 and met the inclusion criteria were categorized into the treatment group and the control group. Patients from the control group were administered basic Western Medicine therapy, whereas patients from the treatment group were administered basic Western Medicine therapy plus CSS by gastric tube injection. Subsequently, the time to first anal exhaustion and defecation, time to relief of abdominal distension and pain, days of hospitalization, Traditional Chinese Medicine (TCM) symptom scores, interleukin-6 (IL-6), C-reactive protein (CRP) and procalcitonin (PCT) levels in the 2 groups were recorded and compared.</p><p><strong>Results: </strong>The comparison of clinical efficacy of the treatment group were better than the control group. The TCM symptom score was considerably lower in the treatment group; the inflammation indicators CRP, IL-6, and PCT also decreased statistically when comparing the control group. Furthermore, there were significantly reduced in the time to first exhaustion, time to first defecation, time to relief of abdominal pain and distension, and days of hospitalization in the treatment group versus the control group.</p><p><strong>Conclusion: </strong>CSS could suppress the inflammatory reaction, reduce days of hospitalization, relieve clinical symptoms in AIO patients with reliable efficacy and high safety and is worthy of clinical application.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"45 1","pages":"115-122"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}