Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan最新文献

{"title":"Therapeutic effect of Fuzheng Yixin decoction on cardiac insufficiencythe soluble guanylyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway in a doxorubicin-induced dilated cardiomyopathy rat model.","authors":"Sang Xiuxiu, Lü Shuquan, Wang Feng, Yang Jing, Wang Qingguo, Wang Lixin","doi":"10.19852/j.cnki.jtcm.20260514.002","DOIUrl":"10.19852/j.cnki.jtcm.20260514.002","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of Fuzheng Yixin decoction (, FZYX) and explore its underlying mechanisms in doxorubicin-induced dilated cardiomyopathy (DCM) rat model.</p><p><strong>Methods: </strong>Sprague-Dawley rats were intraperitoneally injected with doxorubicin for 6 consecutive weeks. Ultra-high-perform ance liquid chromatography Q-exactive mass spectrometry was utilized to obtain mass spectrum data for FZYX. The rats were then intragastrically injected with low-dose FZYX, high-dose FZYX, or captopril for 4 weeks. Serum N-terminal pro-brain natriuretic peptide, transthoracic echocardiography, haematoxylin and eosin and Masson staining, electron microscopy, and immunohistochemistry were used to evaluate the efficacy of FZYX. Differentially expressed genes and metabolites in the myocardial tissue of DCM rats following FZYX intervention were subsequently identified through transcriptomics and non-targeted metabolomics. Finally, the influence of FZYX on the expression of natriuretic peptide precursor A (Nppa), natriuretic peptide precursor B (Nppb), soluble guanylyl cyclase (sGC), protein kinase G (PKG), and PKG-1α in DCM rats was verified through quantitative polymerase chain reaction (qPCR), Western blotting (WB) based on the results of transcriptomics and non-targeted metabolomics analyses.</p><p><strong>Results: </strong>FZYX alleviated body weight loss; inhibited ventricular dilatation; restored impaired heart function, ruptured sarcomeres and mitochondrial damage, and pathological changes; and reduced collagen deposition. Transcriptomic and non-targeted metabolomic results revealed that FZYX regulated the expression of sGC-cyclic guanosine monophosphate (cGMP)-PKG pathway-related genes (Nppa, Nppb) and metabolites such as cGMP, 5'-guanylic acid, adenosine. qPCR and WB demonstrated that FZYX suppressed the expression of Nppa and Nppb and increased the expression of sGC, which led to a further increase in the level of PKG and PKG-1α.</p><p><strong>Conclusion: </strong>These findings suggest that the cardioprotective effect of FZYX may be mediated through the restoration of the sGC-cGMP-PKG signaling pathway. FZYX may provide a new strategy for clinical application against DCM.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"854-863"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory effects and mechanisms of the acupuncture-induced complement component 1q on the high mobility group box 1 -receptor for advanced glycation end products-nuclear factor kappa-B pathway at Zusanli (ST36).","authors":"Kang Xiaochun, W U Sinuo, L I Ningcen, X U Wenyue, X U Zhifang, Thong Yikchih, L I Peiyun, T U Shiwei, M A Ning, L I Yanwei, Dou Baomin, Tan Wenjun, Guo Jing, Guo Yi, Pan Xingfang, Lü Zhongxi","doi":"10.19852/j.cnki.jtcm.20251201.001","DOIUrl":"10.19852/j.cnki.jtcm.20251201.001","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate what are the crucial regulators and mechanisms involved in regulating the inflammatory responses at Zusanli (ST36).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Initially, we utilized enzyme-linked immunosorbent assay (ELISA) to detect the variations of high mobility group box 1 (HMGB1), interleukin-10 (IL-10), and complement component 1q (C1q) concentrations at Zusanli (ST36) on day 1 (D1), day 3 (D3), day 5 (D5) and day 7 (D7) after acupuncture to clearly depict the time-dependent changes of these inflammatory substances. Subsequently, we utilized C1qa-knockout (C1qa-KO) mice to investigate the role of acupuncture-induced C1q in inflammatory responses at Zusanli (ST36). We utilized hematoxylin and eosin staining to observe the inflammatory morphological alterations, examined the activation of the NF-κB pathway by immunofluorescence and assessed HMGB1 and IL-10 changes using ELISA. Lastly, to uncover the specific mechanism by which C1q regulates the acupuncture-induced inflammatory responses at Zusanli (ST36), we employed Western blot (WB) to measure the expression levels of receptor of advanced glycation end products (RAGE), leukocyte associated immunoglobulin like receptor 1 (LAIR-1), and src homology region 2 domain-containing protein tyrosine phosphatase 1 (SHP-1) proteins and used immunofluorescence to detect the polarization of classically activated macrophages (M1) and alternatively activated macrophages (M2).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Compared with the wild-type group, the levels of HMGB1 and C1q of acupuncture (ACU) group at Zusanli (ST36) were increased on D3 after acupuncture, while the level of IL-10 decreased. With continued higher level of HMGB1, both C1q and IL-10 level were increased on D7. After knocking out C1q, compared with the ACU group, the C1qa-KO+acupuncture (C1q&lt;sup&gt;-/-&lt;/sup&gt;+ACU) group exhibited further aggravated inflammatory infiltrations in the epidermal layer, dermal layer, and muscular layer. At Zusanli (ST36), the level of HMGB1 was further increased, accompanied by an intensified activation of the NF-κB pathway. Meanwhile, the level of IL-10 exhibited a downward tendency, which jointly led to the exacerbation of inflammatory responses at Zusanli (ST36). In comparison with the ACU group, the C1q&lt;sup&gt;-/-&lt;/sup&gt;+ACU group showed a reduction in SHP-1 levels, a downward tendency of LAIR-1 expression, whereas the expression of RAGE exhibited an upward inclination. Furthermore, the number of M1 macrophages at Zusanli (ST36) increased significantly, in stark contrast to a pronounced decline in the number of M2 macrophages.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Zusanli (ST36) acupuncture initiates a time-regulated inflammatory cascade might through the following mechanism: HMGB1 release (D1) triggers C1q upregulation (D3), culminating on D7 with C1q binding to LAIR-1, which recruits SHP-1 to inhibit HMGB1-RAGE-NF-κB signaling &lt;i&gt;via&lt;/i&gt;M2 polarization and IL-10 feedback, ensuring precise","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"844-853"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics and network pharmacology analysis of mechanisms underlying amelioration of tic disorders in rats by Jiawei Huangan Lipi decoction.","authors":"Chen Lijin, Chen Linghui, Wang Chengrui, Fang Yijun, Gan Liping, Hang Jinyu","doi":"10.19852/j.cnki.jtcm.2026.04.012","DOIUrl":"10.19852/j.cnki.jtcm.2026.04.012","url":null,"abstract":"<p><strong>Objective: </strong>To further investigate the mechanism of Jiawei Huangan Lipi decoction (, JHD) in treating tic disorders (TD) based on metabolomics and network pharmacology.</p><p><strong>Methods: </strong>The TD model rats were established using iminodipropionitrile and Shengdahuang (<i>Radix Et Rhizoma Rhei Palmati</i>) powder, combined with tail clamping and cold stimulation to induce pathology. Liquid chromatography-mass spectrometry (LC-MS) was used to analyse the chemical constituents of JHD, integrated network pharmacology to predict its therapeutic targets and pathways, and validated findings through reverse transcription quantitative polymerase chain reaction, Western blot and metabolomics. LC-MS-based serum metabolomics coupled with pattern recognition techniques identified endogenous differential metabolites and elucidated associated metabolic pathways.</p><p><strong>Results: </strong>Integrated metabolomics and network pharmacology revealed JHD's 744 compounds targeting 247 genes, notably ras-related C3 botulinum toxin substrate-alpha serine/threonine kinase 1, interleukin 6, tumor necrosis factor, estrogen receptor 1, interleukin-1β were highlighted, indicating that JHD may mitigate the incidence of TD by modulating these pivotal genes. The identified targets were predominantly enriched in pathways related to cancer, lipid metabolism and atherosclerosis, malaria, cAMP signaling, and neuroactive ligand-receptor interactions. Metabolomics identified 255 differential metabolites in TD, with JHD reversing 85 linked to linoleic acid, taurine, and biotin metabolism pathways. These pathways may underpin JHD's therapeutic effects against TD.</p><p><strong>Conclusion: </strong>The study systematically explored JHD's mechanism by cross-integrating metabolomics-derived biomarker pathways with network pharmacology predictions, and it may be a useful alternative therapy for the treatment of TD.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"916-926"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Yishen Jiangzhuo granules in the treatment of chronic kidney disease stages 3-4: a retrospective cohort study.","authors":"Ruan Yaqing, Ruan Shiwei, Y E Binhua, Y U Yongxin, Zheng Kailin","doi":"10.19852/j.cnki.jtcm.20260423.001","DOIUrl":"10.19852/j.cnki.jtcm.20260423.001","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the impact of Yishen Jiangzhuo granules on endpoint events in patients with chronic kidney disease (CKD) stages 3-4.</p><p><strong>Methods: </strong>Based on real-world data, a retrospective analysis was conducted on patients with CKD stages 3-4 who were treated at a single hospital between January 2014 and December 2022. Patients taking Yishen Jiangzhuo granules > 6 months comprised the exposed group; others were non-exposed. The primary outcome was a composite kidney endpoint. Baseline characteristics were collected. Propensity score matching (PSM) balanced covariates. Multivariable Cox regression identified risk/protective factors. Dose-response and threshold effects were assessed using restricted cubic spline (RCS) curves.</p><p><strong>Results: </strong>After PSM, 335 matched cases (87 exposed, 248 non-exposed) showed balanced baselines. Endpoint events differed significantly (38 <i>vs</i>174 events, <i>P <</i> 0.05). The estimated glomerular filtration rate (eGFR) slope was －3.88 mL·(1.73 m²·min·year)^-1 in the exposed group. Multivariable Cox regression indicated lower endpoint risk in the exposed group [<i>HR</i>= 0.567, 95% <i>CI</i> (0.384, 0.838)]. The eGFR slope was the strongest predictor; hypoalbuminemia, elevated BUN, and elevated Scr were also independent risk factors (<i>P <</i> 0.05). A linear relationship existed between eGFR slope and endpoint events (<i>P</i>-nonlinear = 0.165), with a risk threshold at －3.6 mL·(1.73 m²·min·year)^-1.</p><p><strong>Conclusion: </strong>Yishen Jiangzhuo granules may help stabilize renal function, slow the annual decline rate of eGFR, and reduce the risk of CKD progression in patients with stages 3-4 CKD. The eGFR slope is the most significant predictor of endpoint events, with a critical threshold at －3.6 mL·(1.73 m²·min·year)^-1.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"990-999"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Jinlong capsule on the survival of patients with hepatocellular carcinoma: a propensity score matching study.","authors":"Shi Ke, Zhang Yi, Sun Lina, Wang Xianbo, Feng Ying","doi":"10.19852/j.cnki.jtcm.2026.04.015","DOIUrl":"10.19852/j.cnki.jtcm.2026.04.015","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of Jinlong capsule on the overall survival (OS) rates of patients with hepatocellular carcinoma (HCC) at various stages of the disease.</p><p><strong>Methods: </strong>A total of 799 patients diagnosed with HCC between January 2016 and December 2019 were enrolled. The three-year OS rate of the Jinlong group (<i>n =</i> 144) was compared with that of the control group (<i>n =</i> 655). To minimize potential bias, propensity score matching (PSM) was applied. Kaplan-Meier survival analysis was used to assess the OS rates of different subgroups, with statistical significance determined by the log-rank test.</p><p><strong>Results: </strong>The Cox regression model revealed that Jinlong treatment was independently associated with an improved three-year OS. The Jinlong group had a significantly higher OS rate than the control group, with an adjusted hazard ratio of 0.48 (95% confidence interval: 0.38-0.60; <i>P <</i>0.001). After applying PSM at a 1∶2 ratio, 140 patients were included in the Jinlong group and 280 in the control group. The OS rate for the Jinlong group was substantially longer than that for the control group (65.7% <i>vs</i>48.2%, <i>P <</i>0.0001). Additionally, the aHR for Jinlong use showed a dose-response effect: 0.36 for 3-12 months, 0.28 for 12-24 months, and 0.09 for > 24 months of use. Compared to the control treatment, Jinlong treatment consistently reduced the risk of death within three years, of most subgroups.</p><p><strong>Conclusions: </strong>Jinlong treatment significantly improved the three-year survival rate of patients with HCC. These findings provide a foundation for further studies into the effectiveness of Jinlong capsule in the treatment of HCC.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"951-960"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal essential oils in therapy: advances in clinical applications and delivery mechanisms.","authors":"Liang Yong, Guan Qiuyan, Chen Yi, W U Wei, Yang Ming, Tang Fangrui, Wang Yawen, Pan Deng, Huang Xiaoying, L I Huiting","doi":"10.19852/j.cnki.jtcm.2026.04.022","DOIUrl":"10.19852/j.cnki.jtcm.2026.04.022","url":null,"abstract":"<p><p>This review comprehensively examines the therapeutic mechanisms, formulation advancements, and clinical applications of intranasal essential oil (EO) delivery, aiming to highlight its potential as a modern therapeutic approach. A systematic literature search was conducted in PubMed and Web of Science up to May 2024, focusing on preclinical and clinical studies. Data on target diseases, delivery mechanisms, formulation innovations, and therapeutic effects were extracted and analyzed. Intranasal EO delivery demonstrates significant therapeutic potential for neurological, respiratory, cardiovascular, and metabolic disorders. Advanced delivery systems, including nanoemulsions, liposomes, and nasal in situ gels, enhance EO stability, bioavailability, and targeted release. Mechanistically, EOs exert effects through neurotransmission modulation, anti-inflammatory pathways, and vascular regulation, primarily <i>via</i> the olfactory and trigeminal nerves. Clinical evidence supports the efficacy of intranasal EOs in conditions such as anxiety, depression, allergic rhinitis, and hypertension, although further optimization is needed to minimize irritation and improve patient adherence. Intranasal delivery of EOs offers a promising strategy for enhancing therapeutic administration and expanding clinical applications. Future research should focus on developing advanced <i>in vivo</i> pharmacokinetic evaluation tools, optimizing delivery systems, ensuring safety, and integrating EOs with conventional therapies to support their broader clinical translation.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"1026-1041"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Heshu Xiaoji pills combined with standard treatment strategy in hepatitis B virus-related hepatocellular carcinoma: a single-center, open-label, prospective controlled, real-world cohort study.","authors":"Zhu Xiaoning, Yin Yue, Kong Yuan, Peng Mengyun, Peng Zhaoxuan, Zheng Ding, Wang Xiaodong, Han Yunwei, L I Bo, Liu Jurong, Wang Encheng, Tian Zhen, Peng Qinghua, Jiang Yuanyuan, M I Shaoping, Liu Yong, P U Qingrong, Guo Yongcan, H E Qizhou, Cheng Chunxia, L I Linghua, Jia Hong, Wang Jing","doi":"10.19852/j.cnki.jtcm.2026.04.016","DOIUrl":"10.19852/j.cnki.jtcm.2026.04.016","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness and safety of Heshu Xiaoji pills (HSXJ, ) as an adjunct to standard treatment in patients with hepatitis B virus-related hepatocellular carcinoma.</p><p><strong>Methods: </strong>Overall, 201 patients enrolled between May 2020 and February 2022 received either HSXJ plus standard treatment (TCM group, <i>n =</i> 136) or standard treatment alone (Control group, <i>n =</i> 65). Follow-up continued until February 2023. Propensity score matching (PSM) (2∶1) was used to adjust for baseline differences, yielding 61 TCM and 39 control patients. Overall survival (OS), progression-free survival (PFS), and safety were compared using multivariate Cox proportional hazard regression.</p><p><strong>Results: </strong>Before PSM, OS and PFS were significantly longer in the TCM group than in the Control group (OS: 609 <i>vs</i> 500 d; PFS: 609 <i>vs</i> 507 d). After PSM, PFS remained significantly longer (551 <i>vs</i> 449.5 d), but OS differences were not statistically significant. Adverse events were comparable between groups. Subgroup analysis identified patients with cirrhosis, prior resection or local therapy, Child-Pugh A stage, HBV-DNA ≥ 2000 IU/mL, and alpha-fetoprotein ≤ 200 ng/mL as the most responsive to this TCM therapy.</p><p><strong>Conclusions: </strong>HSXJ combined with standard treatment strategy significantly improved PFS in patients with HBV-related HCC without added safety risks.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"961-971"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a nomogram for anxiety and depression in patients with Sjögren's syndrome by combining tongue and pulse characteristics: a cross-sectional study based on a prospective cohort.","authors":"Shan Xueyan, H E Jiale, Guo Zilin, Pang Fengtao, Liu Ruihua, Liu Ying, Jiang Ping, J I Wei, Y U Jing, Zhou Xinyao, Tang Xiaopo","doi":"10.19852/j.cnki.jtcm.2026.04.017","DOIUrl":"10.19852/j.cnki.jtcm.2026.04.017","url":null,"abstract":"<p><strong>Objective: </strong>To develop and validate a predictive model for predicting psychological complications of Sjögren's syndrome (SS) in combination with tongue and pulse characteristics.</p><p><strong>Methods: </strong>This cross-sectional study was based on a prospective cohort study including SS patients recruited from 30 major tertiary hospitals in China. Nomograms were developed based on the clinical characteristics, tongue and pulse manifestations, and laboratory tests of these patients, and univariate and multivariate logistic regression analyses were used to screen for various correlates of anxiety and depression, and the column charts were evaluated using the area under the curve (AUC), calibration curves, and decision curve analysis.</p><p><strong>Results: </strong>A total of 444 patients were included, comprising 424 females (95.5%) and 20 males (4.5%), with a mean age of (46 ± 13) years. The prevalence of anxiety and depression was 45.5% (<i>n =</i> 202) and 42.1% (<i>n =</i> 187), respectively. Peeled tongue was associated with higher rates of both anxiety and depression among SS patients [odds ratio (<i>OR</i>) for anxiety = 0.44, 95% <i>CI</i> (0.26, 0.74), <i>P =</i> 0.002; <i>OR</i> for depressio<i>n =</i> 0.44, 95% <i>CI</i> (0.27, 0.73), <i>P =</i> 0.002]. Regarding pulse diagnostics, a thready pulse was linked to increased anxiety [<i>OR</i>= 1.99, 95% <i>CI</i>(1.11, 3.60), <i>P =</i> 0.022], while a slippery pulse correlated with depression [<i>OR</i> = 0.32, 95% <i>CI</i>(0.14, 0.74), <i>P =</i> 0.007]. Nomograms developed from these findings demonstrated good predictive performance, with AUC values of 0.767 for anxiety and 0.741 for depression in both training and validation cohorts.</p><p><strong>Conclusions: </strong>Integrating Traditional Chinese Medicine diagnostics with conventional clinical assessments provides a robust predictive model for psychological comorbidities in SS. The innovative approach enhances personalized management, offering a pathway for targeted interventions to treat anxiety and depression effectively in affected patients.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"972-981"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of acupuncture and moxibustion combined with core stabilization training on the function of transverse abdominal muscle and pelvic floor muscle in women with postpartum pelvic pain.","authors":"Shi Ling, Yang Chengcheng, Huang Li, Deng Linwen","doi":"10.19852/j.cnki.jtcm.2026.04.020","DOIUrl":"10.19852/j.cnki.jtcm.2026.04.020","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of acupuncture and moxibustion combined with core stabilization exercises (CSE) in enhancing the function of the transverse abdominal muscle (TAM) and pelvic floor muscle in postpartum women with pelvic pain.</p><p><strong>Methods: </strong>This retrospective cohort study included 205 postpartum women with moderate to severe pelvic pain [visual analog scale (VAS) score ≥ 4] between January 2020 and January 2022. Participants were allocated to either a control group receiving CSE (<i>n</i>= 93) or a joint treatment group receiving CSE with acupuncture and moxibustion (<i>n =</i>112). Outcomes assessed included pain relief (VAS), TAM thickness (ultrasound measurement), pelvic floor muscle recovery (manual assessment), urinary incontinence pad test, international consultation on incontinence questionnaire-short form, incontinence quality of life questionnaire, sexual satisfaction (validated questionnaire), quality of life world health organization quality of life questionnaire-abbreviated version, and depression (Self-Rating Depression Scale).</p><p><strong>Results: </strong>Both groups experienced significant reductions in pelvic pain, with superior outcomes noted in the joint treatment group (<i>P =</i>0.008). Pelvic floor muscle recovery and sexual satisfaction rates were comparable between groups. The SE group demonstrated better post-treatment scores for urinary symptoms and quality of life related to urinary incontinence. TAM thickness remained unchanged in both groups. Quality of life and depression scores improved similarly across both groups post-treatment.</p><p><strong>Conclusion: </strong>While acupuncture paired with CSE did not greatly surpass CSE alone in all outcomes, it provided enhanced pain relief and similar psychological benefit. These findings suggest a potential role for integrative approaches in managing postpartum pelvic pain, though longer-term studies with more objective measures are needed.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"1009-1017"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaofu Zhuyu decoction can inhibit the progression of endometriosis fibrosis through the transforming growth factor-β1/ smads signaling pathway mediated by 5' adenosine monophosphate-activated protein kinase.","authors":"L I Bingbing, Ding Meiqi, Chen Xiangying, L I Wenzhe, Wei Chao, Y U Bin, M A Xiaona, Sun Xinhui","doi":"10.19852/j.cnki.jtcm.2026.04.004","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2026.04.004","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the mechanisms by which Shaofu Zhuyu decoction (SFZYD, ) modulates fibrosis in a mouse model of endometriosis.</p><p><strong>Methods: </strong>Mice were divided into control, endometriosis model, low-dose SFZYD, high-dose SFZYD, and dinorgestrel groups. Ectopic lesion weights and volumes were evaluated post-intervention. Uterine or lesion morphology and fibrosis were assessed using hematoxylin/eosin and Masson's trichrome and Sirius red staining, respectively. Gene expression levels of 5' adenosine monophosphate-activated protein kinase (AMPK), transforming growth factor β1 (TGF-β1), collagen type 1 alpha 1 chain (COL1A1), alpha smooth muscle actin (α-SMA), and connective tissue growth factor (CTGF) were detected using quantitative real-time polymerase chain reaction. Protein expression levels of AMPK, p-AMPK, TGF-β1, Smad2/3, p-Smad2/3, COL1A1, α-SMA and CTGF were detected using immunohistochemistry or Western blotting.</p><p><strong>Results: </strong>Staining revealed excessive ectopic lesion fibrosis, and p-AMPK/AMPK expression was downregulated in the model group, whereas TGF-β1, Smad2/3, COL1A1, α-SMA, and CTGF expression was upregulated. SFZYD-L group showed the greatest effect in reducing ectopic lesion size and inhibiting fibrosis. These changes were correlated with the activation/ phosphorylation of AMPK, suppression of TGF-β1 and Smad2/3 expression, and downregulation of COL1A1, α-SMA, and CTGF expression, suggesting a potential association with AMPK modulation.</p><p><strong>Conclusion: </strong>SFZYD significantly inhibits both the progression of ectopic lesions and the development of fibrosis in a mouse model of endometriosis. These effects are potentially mediated through the regulation of the AMPK/TGF-β1/Smads signaling pathway.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 4","pages":"809-820"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}