Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan最新文献

{"title":"Tongue color tones in Traditional Chinese Medicine correlate with liver histology of metabolic dysfunction-associated steatohepatitis in morbidly obese patients undergoing metabolic and bariatric surgery.","authors":"Cen Zhikang, Huang Bing, Zhang Pengfei, Liu Dongyang, M O Yanxin, Zhu Fei, Fan Mengqi, N I Zheng, X U Ying, Liu Wei, W U Shuduo, X U Aimin, Song Erfei, Y E Dewei","doi":"10.19852/j.cnki.jtcm.20250821.001","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.20250821.001","url":null,"abstract":"<p><strong>Objective: </strong>To determine the association of tongue color tones in morbidly obese patients with various liver histological characteristics of metabolic dysfunction-associated steatohepatitis (MASH), which is the advanced subtype of metabolic dysfunction-associated steatotic liver disease (MASLD).</p><p><strong>Methods: </strong>A total of 60 morbidly obese adults who underwent metabolic and bariatric surgery were recruited. Liver biopsies were available for all participants and were subjected to histological assessment. The association of tongue color tones with histological parameters in the liver was investigated.</p><p><strong>Results: </strong>MASH-related histological characteristics in the liver were closely associated with color features in distinct zones of the tongue. The values for color channels red (R), green (G), and blue (B) were increased in subjects with histological features of steatosis. Likewise, the histological characteristic of lobular inflammation was associated with distinct panels of RGB values for tongue edge zones and tongue coating. RGB values in the tongue exhibited a step-wise increase in line with grading score of liver histology. In contrast, tooth-sign on the tongue was dissociated with histological features of MASH.</p><p><strong>Conclusion: </strong>Our clinicopathological study demonstrated a close association of color tones in the tongue with MASH-related histological characteristics in the liver of morbidly obese patients, supporting the application of tongue inspection in Traditional Chinese Medicine as a promising approach to non-invasive diagnosis of MASLD/MASH.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 2","pages":"480-489"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying fasting-related changes in pulse patterns at , , and using a modern Traditional Chinese Medicine pulse-diagnostic platform.","authors":"Wang Meng, X U Shijie, L U Yu, Zhao Kaiwei, W U Qiong, Wang Chao","doi":"10.19852/j.cnki.jtcm.2026.02.019","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2026.02.019","url":null,"abstract":"<p><strong>Objective: </strong>To quantify pulse waveform features in healthy adults under different fasting states and to explore the relationship between gastrointestinal \"deficiency\" and \"excess\" states [in the Traditional Chinese Medicine (TCM) sense] and corresponding pulse patterns at key pulse positions.</p><p><strong>Methods: </strong>Fifty-one healthy participants were enrolled and underwent standardized pulse recording at three time points: pre-fasting (Day 0), during-fasting (Day 4), and post-fasting (Day 7). Pulse signals were collected at the Left <i>Cun</i>, Right <i>Cun</i>, and Right <i>Guan</i> positions, which are classically associated with the heart, lungs, and spleen, respectively. Quantitative pulse parameters were extracted and compared across the three stages using statistical analyses to detect within-subject changes.</p><p><strong>Results: </strong>Significant differences in pulse patterns were observed across the three fasting stages, with the most pronounced changes occurring between pre-fasting and post-fasting. Overall pulse strength and related quantitative indices decreased from pre-fasting to post-fasting, and these changes were correlated with the relative fullness or emptiness of the gastrointestinal system. The Left <i>Cun</i>, Right <i>Cun</i>, and Right Guan positions contributed most strongly to discriminating between fasting stages.</p><p><strong>Conclusions: </strong>This study provides quantitative evidence that gastrointestinal loading status is reflected in measurable changes in pulse characteristics at specific TCM pulse positions, supporting classical TCM theories regarding the roles of the stomach and spleen in <i>Qi</i>and blood regulation. These findings offer a preliminary bridge between traditional pulse diagnosis and modern quantitative assessment, and lay the groundwork for future studies integrating TCM concepts with contemporary biomedical methods.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 2","pages":"470-479"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial effects of Huanglian Jiedu decoction ( ) on metabolic syndrome: a prospective randomized controlled clinical trial.","authors":"X U Pingyuan, Zhu Heng, Zhou Ruonan, Wei Yaping, Zhu Ziwei, X U Fangyuan, Xiang Yingying, Cao Yue, Shen Lixuan, Wang Ziwei, Xue Yingying, Y U Xizhong, Fang Penghua, Shang Wenbin","doi":"10.19852/j.cnki.jtcm.2026.02.013","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2026.02.013","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of Huanglian Jiedu decoction (, HLJDD) in patients with metabolic syndrome (MS) and to elucidate its potential underlying mechanisms.</p><p><strong>Methods: </strong>A total of 132 participants were enrolled and randomly divided into the HLJDD group and the control group. Participants in the HLJDD group received a 3-month HLJDD treatment in addition to lifestyle guidance, while the control group received only lifestyle guidance. Anthropometric indices, blood lipid profiles, liver function indices, glucose homeostasis, insulin sensitivity, inflammatory profiles, and the brown adipokine fibroblast growth factor 21 (FGF-21) were measured both at baseline and at the end of the trial.</p><p><strong>Results: </strong>The study demonstrated that administering HLJDD for three months significantly reduces the body weight [8.91% (6.03%-10.22%) <i>vs</i>5.58% (3.31%-8.70%), <i>P</i><0.01], body mass index [8.55% (6.08%-10.16%) <i>vs</i>5.37% (3.27%-8.54%), <i>P</i><0.01], waist circumference [9.56% (6.63%-14.41%) <i>vs</i> 7.43% (3.11%-11.69%), <i>P</i> <0.01] as well as the metabolic profiles of patients with metabolic syndrome. Additionally, it was observed that the HLJDD regimen led to lower serum levels of inflammatory cytokines IL-6 (-45.03% <i>vs</i>-22.90%, <i>P</i> < 0.01), IL-17A (-23.34% <i>vs</i> -9.13%, P < 0.05), TNF-α (-33.78% <i>vs</i>-11.02%, <i>P</i> < 0.01) and FGF-21 (<i>P</i> < 0.05) when compared to the control group.</p><p><strong>Conclusion: </strong>It can be concluded that HLJDD contributes to ameliorating metabolic disorders in individuals suffering from metabolic syndrome. The data also imply that the beneficial effects of HLJDD on metabolism might be attributed to its role in enhancing FGF-21 secretion, which is otherwise compromised due to metabolic inflammation.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 2","pages":"411-417"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Jiawei Simiaoyongan granules in the treatment of non-infectious anterior uveitis: a randomized open-label trial.","authors":"Sun Wu, Chu Liqun, Zhou Wanyu, Shi Hang, Chen Shuiling, Liang Yu, W U Jianguo, Wei Dong, Liu Yushen, Zhang Qi","doi":"10.19852/j.cnki.jtcm.2026.02.014","DOIUrl":"10.19852/j.cnki.jtcm.2026.02.014","url":null,"abstract":"<p><strong>Objective: </strong>To observe the clinical efficacy and safety of Chinese herbal medicine Jiawei Simiao Yongan granules (, JWSMYAG) in the treatment of non-infectious anterior uveitis (NIAU).</p><p><strong>Methods: </strong>We conducted a single-center, randomized, open-labeled clinical trial in adults with NIAU. Patients received standard treatment or a combination of JWSMYAG (twice daily) for three months, with a 3-month withdrawal period for observation. The primary endpoint was the recurrence rate within six months.</p><p><strong>Results: </strong>A total of 98 patients were included in the intention-to-treat analysis, including 49 patients in the Traditional Chinese Medicine (TCM) group and 49 patients in the control group. Compared with the control group, the number of relapses was significantly lower in the TCM group [24.5% <i>vs</i>6.1%, <i>P</i> = 0.0224; Hazard Ratio = 0.208, 95% Confidence Interval (0.059, 0.737)]; in addition, patients in the TCM group had lower symptom scores of eye pain, insomnia, and bitter taste within two weeks (all <i>P</i> < 0.05). There was no significant difference between the two groups in terms of the difference in best corrected visual acuity change over six months, the number of intraocular pressure elevations > 10 mm Hg, the scoring of anterior chamber cells, the number of patients with keratic precipitates (+) after 1/2 weeks of treatment, and the scores of conjunctival hyperemia, headache, photophobia, and lacrimation. The difference in the number of adverse events between the two groups over six months was not statistically significant.</p><p><strong>Conclusion: </strong>JWSMYAG can reduce the recurrence rate of NIAU, alleviate ocular pain, insomnia, and bitter taste symptoms in patients with NIAU, and have a favorable safety profile.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 2","pages":"418-426"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13146387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous auricular vagus nerve stimulation improves emotional and cognitive functions in post-traumatic stress disorder rats through anti-inflammation, neuroprotection, and modulation of the hippocampal nuclear factor erythroid 2-related factor 2-heme oxygenase-1-glutathione peroxidase 4 pathway.","authors":"Zheng Yanfeng, Zhang Xinjiang, Zhang Xiaomeng, L I Xiangji, Xin Chen, Kong Jingwei, Wang Xin, Sun Lan, Rong Peijing","doi":"10.19852/j.cnki.jtcm.2026.02.006","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2026.02.006","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the role and potential molecular mechanisms of transcutaneous auricular vagus nerve stimulation (taVNS) in post-traumatic stress disorder (PTSD).</p><p><strong>Methods: </strong>A single prolonged stress (SPS) model of PTSD was used to conduct behavioral tests and evaluate the effects of taVNS on the emotion-cognitive function in PTSD animals. Focusing on the prefrontal cortex-hippocampus brain region, we systematically evaluated the growth status of neurons and astrocytes, as well as the level of microglial-mediated neuroinflammation. Key indicators of the nuclear factor erythroid 2-related (NRF2)-heme oxygenase-1 (HO-1)-glutathione peroxidase 4 (GPX4) signaling pathway were detected and analyzed. Additionally, immune and oxidative stress levels in peripheral plasma were also assessed.</p><p><strong>Results: </strong>Two weeks of taVNS significantly improved the abnormal emotion-cognitive function in PTSD animals and partially inhibited peripheral oxidative stress injury and immune-inflammatory responses. Compared with the prefrontal cortex, taVNS markedly alleviated hippocampal neuron loss, microglial activation, and astrocyte dysfunction in PTSD rats, suggesting that the NRF2-HO-1-GPX4 signaling pathway may play a critical role in this process.</p><p><strong>Conclusion: </strong>taVNS extensively modulates the functions of neurons and glial cells by regulating both central and peripheral oxidative stress and immune-inflammatory responses, thereby ameliorating the abnormal emotional and cognitive functions observed in PTSD animals.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 2","pages":"326-338"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanic evaluation of Jisheng Shenqi Wan on calcium oxalate kidney stones: an integrated network pharmacology and metabolomics.","authors":"Shi Bing, L I Yang, Jiang Zhuocheng, Qin Guozheng, Zhao Fan","doi":"10.19852/j.cnki.jtcm.20250929.001","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.20250929.001","url":null,"abstract":"<p><strong>Objective: </strong>To understand the efficacy of Jisheng Shenqi Wan (JSSQW, ) in treating calcium oxalate kidney stones (KS) and to investigate the mechanism of JSSQW action by combining network pharmacology with metabolomics analysis based on ultra-high performance liquid chromatography combined with tandem electrostatic field orbital trap high-resolution mass spectrometry (UHPLC-Q/Orbitrap HRMS).</p><p><strong>Methods: </strong>The chemical components of JSSQW absorbed into rat blood were identified by UHPLC-Q/Orbitrap HRMS. The identified components were introduced into the Bioinformatics Analysis Tool for Molecular mechanism of Traditional Chinese Medicine platform to screen for target genes, followed by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and disease enrichment analysis. A KS rat model was generated using the oxalic acid precursor method to examine the efficacy of JSSQW for treating KS. Serum metabolomics was used to monitor changes in endogenous substances in KS rats after JSSQW intervention.</p><p><strong>Results: </strong>Twenty-three chemicals from JSSQW were identified in the blood of JSSQW gavage-administered rats. KEGG enrichment analysis predicted the top 20 signaling pathways affected by these 23 chemicals. Disease enrichment analysis showed that the target genes of these 23 chemicals were enriched in diseases of the urinary system and endocrine system, including kidney stones. In a KS rat model, JSSQW inhibited the aggregation of calcium oxalate crystals, reduced renal tubular injury, lowered the renal index, and improved biochemical indicators (blood creatinine, blood urea nitrogen). Serum metabolomics identified 25 differential metabolites that responded to JSSQW treatment. They were mainly lipids, with phosphatidylethanolamine and phosphorylcholine and their derivatives accounting for the highest proportion. Metabolic pathway analysis showed that the changes in differential metabolites were related to multiple metabolic pathways, especially sphingolipid metabolism and sphingolipid signaling pathways.</p><p><strong>Conclusions: </strong>JSSQW can inhibit the aggregation of calcium oxalate crystals in the kidneys, reduce tubular injury, and improve kidney function in KS rats. Its mechanism of action may be related to regulating disordered metabolites and metabolic pathways, especially glycerol phospholipid metabolism, sphingolipid metabolism, and sphingolipid signaling.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 2","pages":"371-381"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moxibustion alleviates autophagy and inhibits ferroptosis to improve cardiac function in rats with post-myocardial infarction heart failure.","authors":"Gao Bing, Liu Pan, L I Lan, Gong Tiantian, Zhu Ling, L I Lingji, Xia Ran, M A Qiang, H U Jing, Wang Jing","doi":"10.19852/j.cnki.jtcm.2026.02.007","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2026.02.007","url":null,"abstract":"<p><strong>Objective: </strong>To explore the mechanism by which moxibustion alleviates autophagy and inhibits ferroptosis, thereby improving myocardial fibrosis in rats with post-myocardial infarction heart failure (post-MI HF).</p><p><strong>Methods: </strong>We used a rat model of post-MI HF rats. Interventions included moxibustion and intraperitoneal injection of rapamycin (RAPA) along with assessing echocardiography, cardiac pathology, myocardial mitochondrial morphology, co-immunofluorescence, transmission electron microscope, Western blotting, and reverse transcriptase-quantitative polymerase chain reaction.</p><p><strong>Results: </strong>Moxibustion improves the left ventricular ejection fraction and fractional shortening, myocardial cell morphology, and myocardial fibrosis levels induced by post-MI HF. In addition, it reduces the immunofluorescence co-localization intensity of nuclear receptor coactivator 4 (NCOA4) and microtubule-associated protein 1A/1B light chain 3 and decreases the level of intracellular free iron. It suppresses autophagy and ferroptosis-related indicators, downregulates NCOA4 expression, upregulates glutathione peroxidase 4 expression, and decreases lipid peroxidation levels. The activation of autophagy increases NCOA4 expression and promotes ferroptosis. Furthermore, moxibustion counteracts the effects of RAPA.</p><p><strong>Conclusions: </strong>Moxibustion can alleviate myocardial fibrosis and exert cardioprotective effects by regulating autophagy and inhibiting ferroptosis. Our findings indicate that targeting autophagy-induced ferroptosis may serve as a novel therapeutic approach for the treatment of post-MI HF.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 2","pages":"339-349"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No. 2 Kangxianling decoction protects against renal ischemia/reperfusion injury by hypoxia-inducible factor activation.","authors":"Y U Kena, Zhong Liping, Lin Xiaomeng, Chen Jian, H E Liqun, Cai Xudong","doi":"10.19852/j.cnki.jtcm.2026.02.004","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2026.02.004","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of No. 2 Kangxianling decoction (，No. 2 KXLD) on renal tubular injury in renal ischemia/reperfusion injury (RIRI) rats and explore the mechanisms.</p><p><strong>Methods: </strong>Male Sprague-Dawley rats were divided into sham group, RIRI group, No. 2 KXLD group, and FG-4592 group. Rats were pretreated with No. 2 KXLD (30 g·kg^-1·d^-1, i.g.) or FG-4592 (10 mg·kg^-1·d^-1, i.p.) for 7 d and then subjected to renal I/R. Serum creatinine (Scr) and blood urine nitrogen (BUN) were tested after I/R. Periodic acid-Schiff staining and tubular injury biomarkers were measured. Hypoxia-inducible factor (HIF), inflammatory response, and B-cell lymphoma 2/Bcl-2-associated X protein/caspase-9/3 (Bcl-2/Bax/caspase-9/3) signaling were determined. We used human kidney 2 (HK-2) cells in a hypoxia/reoxygenation (H/R) model to verify the study.</p><p><strong>Results: </strong>No. 2 KXLD significantly decreased the levels of Scr by 22.4% and BUN by 19.7% at 48 h after I/R and improved the renal pathological changes in RIRI rats. No. 2 KXLD attenuated the expression of kidney injury molecule-1, neutrophil-gelatinase-associated lipocalin, and tissue inhibitor of metalloproteinase-2 in RIRI rats and H/R-induced HK-2 cells (<i>P <</i> 0.05). Both <i>in vivo</i> and in vitro studies demonstrated that No. 2 KXLD increased hypoxia-inducible factor, erythropoietin, and heme oxygenase 1 levels, suppressed tumor necrosis factor-α and interleukin-6 expressions, and boosted Bcl-2/Bax/caspase-9/3 pathway.</p><p><strong>Conclusions: </strong>No. 2 KXLD might have therapeutic potential on RIRI by inhibiting HIF-mediated inflammation and apoptosis, which provides a theoretical basis for the treatment of patients with renal tubulointerstitial injury.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 2","pages":"306-315"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of abdominal moxibustion at the Zhongji (CV3) in combination with Yiqi Tonglin Yangyin decoction and antibiotics for treating elderly female patients with complicated urinary tract infection.","authors":"H U Yunhao, Zhang Yi, Zhao Min, Zhu Danyang, Jia Xing, Wang Cunzhou","doi":"10.19852/j.cnki.jtcm.2026.02.017","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2026.02.017","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical effect of abdominal moxibustion at the Zhongji (CV3) combined with Yiqi Tonglin Yangyin decoction and antibiotics on elderly women with complicated urinary tract infections.</p><p><strong>Methods: </strong>One hundred and forty-four elderly female patients diagnosed with complicated urinary tract infections and admitted to our hospital were selected for this study. They were randomly assigned to two groups: the dual treatment group, consisting of 72 patients, treated with antibiotics combined with Yiqi Tonglin Yangyin decoction, and the triple treatment group, comprising 72 patients, who received abdominal moxibustion at the Zhongji (CV3) in addition to the dual treatment. The clinical efficacy, Traditional Chinese Medicine (TCM) syndrome score, immune function indicators, oxidative stress status indicators, symptom recovery, and recurrence were evaluated and compared.</p><p><strong>Results: </strong>Before treatment, there was no statistically significant differences observed in the TCM syndrome score, levels of immunoglobulin A (IgA), immunoglobulin M (IgM), xanthine oxidoreductase (XOD), malondialdehyde (MDA) and superoxide dismutase (SOD) between the two groups (<i>P ></i>0.05). After treatment, the triple group exhibited a significantly higher overall response rate (95.9% > 84.7%) compared to the dual group. Moreover, the triple group demonstrated elevated levels of IgA, IgM, and SOD, a lower TCM syndrome score, and reduced levels of XOD and MDA, along with a diminished recurrence rate. Additionally, patients in the triple group experienced a shorter time to return to normal symptoms, bacteriuria, and a routine urine output.</p><p><strong>Conclusion: </strong>Abdominal moxibustion at the Zhongji (CV3), combined with Yiqi Tonglin Yangyin decoction and antibiotics for treating complicated urinary tract infections in elderly women, can effectively improve the clinical symptoms, TCM syndromes, and immune function of patients. Additionally, it can reduce oxidative stress, promote patient recovery, and lower the recurrence rate with pronounced comprehensive efficacy.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 2","pages":"447-457"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Candidate biomarker identification for blood stasis syndrome among coronary artery disease patients using the Olink proteomics platform.","authors":"L I Hongzheng, Lin Guosheng, Peng Yuxuan, Churov Alexey Viktorovich, Yang Wenwen, Wang Jie, L U Jieming, Liao Feifei, Y U Ruotong, Wei Yue, Zhao Zhiru, L U Aimei, L I Peng, Shen Aling, Long Linzi, Q U Hua, F U Changgeng","doi":"10.19852/j.cnki.jtcm.2026.02.020","DOIUrl":"https://doi.org/10.19852/j.cnki.jtcm.2026.02.020","url":null,"abstract":"<p><strong>Objective: </strong>To identify candidate biomarkers of blood stasis syndrome (BSS) associated with coronary artery disease (CAD) and explore the underlying inflammatory mechanisms.</p><p><strong>Methods: </strong>Using the Olink Target 96 Inflammation panel, we identified plasma proteins in a group of 88 patients comprised of healthy controls (HCs), those with CAD and BSS (CAD-BSS), those with CAD without BSS (CAD-non-BSS), and those with BSS without CAD (non-CAD-BSS) (<i>n =</i> 22 in each group). Protein molecules that were specifically expressed in CAD or BSS were identified by differential expression analyses. Subsequently, potential protein biomarkers were identified using least absolute shrinkage and selection operator regression to enable CAD and BSS differentiation. The potential functional mechanisms of identified proteins were then determined by Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses.</p><p><strong>Results: </strong>Patients with CAD had 31/92 upregulated and 4/92 downregulated proteins compared with those without. Chemokine (C-C motif) ligand 11 (CCL11), CUB domain-containing protein 1, hepatocyte growth factor, sirtuin 2 (SIRT2), eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), CCL25, and tumor necrosis factor (TNF) showed the strongest upregulation (all <i>P <</i>0.0001). Patients with BSS had 8/92 downregulated proteins, specifically CCL28, CCL11, cystatin D, STAM-binding protein, 4E-BP1, matrix metalloproteinase-10, SIRT2, and monocyte chemotactic protein 4, compared with those without (all <i>P</i> < 0.05). The CAD-BSS group had one interleukin-17 (IL-17) upregulated and 10/92 downregulated proteins compared with the CAD-non-BSS group. When compared with the non-CAD-BSS group, the CAD-BSS group had 8 upregulated proteins but only 2 downregulated proteins, namely interleukin-10 receptor subunit alpha (IL-10RA) and TNF-related activation-induced cytokine (both <i>P</i> < 0.05). Totally 10 proteins were identified as potential candidate biomarkers of BSS in CAD patients. After least absolute shrinkage and selection operator regression analysis, two proteins that distinguished between BSS and non-BSS individuals among CAD patients were identified (SIRT2 and 4E-BP1). These proteins are primarily associated with the mechanistic target of rapamycin signaling pathway, which regulates inflammation and oxidative stress.</p><p><strong>Conclusions: </strong>Results suggest that the inflammatory response and mechanistic target of rapamycin signaling pathway participate in CAD and BSS development, and that SIRT2 and 4E-BP1 are prospective protein biomarkers for patients with CAD and BSS.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"46 2","pages":"490-500"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}