International review of neurobiology最新文献_第3页

Altered microbiome influence on the enteric neuromuscular system in amyotrophic lateral sclerosis (ALS). 肌萎缩性侧索硬化症（ALS）患者肠道神经肌肉系统微生物组改变的影响。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-05-16 DOI: 10.1016/bs.irn.2025.04.006

Sadari Manusha, N Varsha, R Varshini, Yuvaraj Sivamani, Kiran Sree Pokkuluri, Sumitha Elayaperumal

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Dysbiosis significantly elevates the probability of altered affective function in Alzheimer disease (AD). 生态失调显著提高阿尔茨海默病（AD）患者情感功能改变的可能性。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-05-03 DOI: 10.1016/bs.irn.2025.04.005

Harsh Kumar, Daljeet Singh Dhanjal, Rajni Dhalaria, Neetika Kimta, Richard Cimler, Kamil Kuča

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Epidemiology of myasthenia gravis. 重症肌无力的流行病学。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-07-05 DOI: 10.1016/bs.irn.2025.04.028

Nils Erik Gilhus, Ari Breiner

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Preface. 前言。

International review of neurobiology Pub Date : 2025-01-01 DOI: 10.1016/S0074-7742(25)00060-1

Murugan Sevanan, Shyamjith Manikkoth, Chandrapragasam Vani, Riddhi Upadhyay

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Animal models of myasthenia gravis. 重症肌无力动物模型。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-07-09 DOI: 10.1016/bs.irn.2025.04.029

Patricia M Sikorski, Linda L Kusner

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Contribution of cellular immune dysregulation to myasthenia gravis pathology. 细胞免疫失调在重症肌无力病理中的作用。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-05-20 DOI: 10.1016/bs.irn.2025.04.035

Alexandra C Bayer, Richard J Nowak, Kevin C O'Connor

{"title":"Contribution of cellular immune dysregulation to myasthenia gravis pathology.","authors":"Alexandra C Bayer, Richard J Nowak, Kevin C O'Connor","doi":"10.1016/bs.irn.2025.04.035","DOIUrl":"https://doi.org/10.1016/bs.irn.2025.04.035","url":null,"abstract":"Myasthenia gravis (MG) is an autoimmune disorder in which autoantibodies attack proteins at the neuromuscular junction, resulting in impaired neuromuscular transmission. Like other autoimmune diseases, MG arises when the immune system fails to distinguish self from non-self, attacking and damaging normal tissues. The pathological response involves not only B cells, responsible for autoantibody production, but also T cells, which provide essential support for B cell pathogenicity. While the precise triggers of this abnormal immune response remain undefined, MG is recognized as a multifactorial disease influenced by immune dysregulation along with genetic and environmental factors. This chapter explores the complex immunopathology of MG, highlighting how these factors collectively contribute to disease development. We examine the physiological development of T and B cell compartments, the tolerance checkpoints designed to prevent autoimmunity, and the consequences of their failure. Finally, we discuss the dysregulation of these cellular compartments in MG, emphasizing their roles in disease progression, the persistence of autoimmunity, and responses to treatment.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"182 ","pages":"43-66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure and function of the neuromuscular junction in health and myasthenia gravis. 健康与重症肌无力神经肌肉接点的结构与功能。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-06-06 DOI: 10.1016/bs.irn.2025.04.036

Jaap J Plomp, Richard G Webster

引用次数: 0

Microbiota dysbiosis impact on the immune system dysregulation in Huntington's disease (HD). 微生物群失调对亨廷顿氏病（HD）免疫系统失调的影响。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-05-02 DOI: 10.1016/bs.irn.2025.04.002

Papia Acharjee, Shambhu Kumar Prasad, Vishal Vikram Singh, Mukulika Ray, Arup Acharjee

{"title":"Microbiota dysbiosis impact on the immune system dysregulation in Huntington's disease (HD).","authors":"Papia Acharjee, Shambhu Kumar Prasad, Vishal Vikram Singh, Mukulika Ray, Arup Acharjee","doi":"10.1016/bs.irn.2025.04.002","DOIUrl":"https://doi.org/10.1016/bs.irn.2025.04.002","url":null,"abstract":"Huntington's disease (HD) is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric impairments caused by Huntingtin (HTT) gene mutations, resulting in the mutant huntingtin (mHTT) protein. Both innate and adaptive immunities play crucial roles in the pathogenesis of HD. In this chapter, we explore the vital role of the gut microbiota in HD, emphasizing its impact on the immune response and brain health via the gut-brain axis. Dysbiosis influences immune responses and HD pathogenesis through microbial metabolites such as short-chain fatty acids (SCFAs) and pathogen-associated molecular patterns (PAMPs). We discuss advanced mathematical models, telemedicine, and biosensors for tracking HD progression and detecting gut dysbiosis. Nutritional interventions to restore microbiota balance and using artificial intelligence and machine learning to predict disease prognosis and personalized treatments have been highlighted. Based on their unique immune profiles and gut microbiota, personalized medicine has been proposed as a promising strategy for effective HD treatment.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"180 ","pages":"57-94"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oro-pharyngeal mucosal microbiome alternations causing immune system dysregulation in schizophrenia. 精神分裂症患者口咽黏膜微生物组改变导致免疫系统失调。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-04-28 DOI: 10.1016/bs.irn.2025.03.003

Deena Krishnan, Puja Ghosh, Nathish Lakshman, Antony Justin, Sivasamy Ramasamy

{"title":"Oro-pharyngeal mucosal microbiome alternations causing immune system dysregulation in schizophrenia.","authors":"Deena Krishnan, Puja Ghosh, Nathish Lakshman, Antony Justin, Sivasamy Ramasamy","doi":"10.1016/bs.irn.2025.03.003","DOIUrl":"https://doi.org/10.1016/bs.irn.2025.03.003","url":null,"abstract":"Schizophrenia is a chronic and thoughtful psychological disorder that affects a person's thinking, feelings, and behaviours. Multi-factorial genetic, environmental, and neurological variables cause it. Recently, more research focused on the human microbiome, which alters the immune system and develops adverse health effects on the human body. The study discusses a possible relationship between the oropharyngeal microbiome and schizophrenia. According to recent studies, the oropharyngeal microbiome may alter the immune system in the human body and cause various psychiatric disorders, including schizophrenia. The oropharyngeal microbiome can cause schizophrenia either by affecting the genes, chromosomes, and immune system in the human body. Additionally, it examines the combined mechanism of how the oropharyngeal microbiome's alterations lead to genetic abnormalities and immune dysregulation in schizophrenia. By combining the various approaches, this chapter offers a comprehensive view of the oropharyngeal microbiome's role in schizophrenia and suggests that microbial alterations could serve as biomarkers or therapeutic targets for the disorder.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"180 ","pages":"125-156"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal microbiota due to prenatal antibiotic as a possible risk factor for Attention-Deficit / Hyperactivity Disorder (ADHD). 产前抗生素引起的微生物群异常可能是注意力缺陷/多动障碍（ADHD）的危险因素。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-04-15 DOI: 10.1016/bs.irn.2025.03.007

Sudharsan Parthasarathy, Bupesh Giridharan, Jogeswar Panigrahi, Longnyu M Konyak, Nokenketla Jamir, Siva Vijayakumar Tharumasivam

{"title":"Abnormal microbiota due to prenatal antibiotic as a possible risk factor for Attention-Deficit / Hyperactivity Disorder (ADHD).","authors":"Sudharsan Parthasarathy, Bupesh Giridharan, Jogeswar Panigrahi, Longnyu M Konyak, Nokenketla Jamir, Siva Vijayakumar Tharumasivam","doi":"10.1016/bs.irn.2025.03.007","DOIUrl":"https://doi.org/10.1016/bs.irn.2025.03.007","url":null,"abstract":"One of the major issues modern medicine faces is the increasing use of antibiotics in reaction to the increased incidence of infectious agents. The current trend of antibiotic overuse contributes to microbial dysbiosis. Recent studies have hypothesized that antibiotic exposure during pregnancy, which alters the composition of the microbiome, might increase the likelihood of attention deficit hyperactivity disorder (ADHD). In addition to the ongoing discussion about the potential links between antibiotic usage, microbiome dysbiosis, and ADHD, there is a rising interest in integrating AI and ML into healthcare practices. Diagnosis, treatment plans, and prognoses are all enhanced by these technological advancements. Remote monitors or telemedicine monitoring are among the management techniques described in this chapter for effectively managing illnesses. Also discussed are ways to halt the progression of diseases by preventative measures that use biosensor technology and dietary approaches. Personalized treatment programs, disease progression stages, and prognosis evaluations are all made possible with the use of artificial intelligence and machine learning. By using these technologies to provide individualized therapy, healthcare practitioners may get a better understanding of ADHD and perhaps improve patient outcomes.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"180 ","pages":"299-328"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0