生态失调显著提高阿尔茨海默病(AD)患者情感功能改变的可能性。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-05-03 DOI:10.1016/bs.irn.2025.04.005
Harsh Kumar, Daljeet Singh Dhanjal, Rajni Dhalaria, Neetika Kimta, Richard Cimler, Kamil Kuča
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引用次数: 0

摘要

肠道菌群组成的变化与许多神经精神疾病有关。虽然肠道生态失调与大脑功能障碍之间的确切联系尚未完全清楚,但最近的数据表明,肠道生态失调可能通过促进神经炎症、胰岛素抵抗、氧化应激和β淀粉样蛋白(Aβ)聚集而促进阿尔茨海默病(AD)的发展。在动物模型中,肠道生态失调的主要特征是厚壁菌门/拟杆菌门比例升高,这可能导致淀粉样前体蛋白(APP)在阿尔茨海默病早期在肠道中积累。益生菌通过恢复肠-脑稳态在预防AD症状中发挥重要作用。本章概述了肠道微生物群及其失调在AD病因学中的作用。此外,还讨论了改变肠道微生物群组成作为AD预防或治疗方法的新见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dysbiosis significantly elevates the probability of altered affective function in Alzheimer disease (AD).

Changes in the makeup of gut microbiota are linked to many neuropsychiatric diseases. Although the exact connection between gut dysbiosis and brain dysfunction is not yet fully understood, but recent data suggests that gut dysbiosis may contribute to the development of Alzheimer's disease (AD) by promoting neuroinflammation, insulin resistance, oxidative stress, and amyloid-beta (Aβ) aggregation. Gut dysbiosis in animal models is primarily characterized by an elevated ratio of Firmicutes/Bacteroidetes which may lead to the accumulation of amyloid precursor protein (APP) in the intestine, in the early stages of AD. Probiotics play a significant role in preventing against the symptoms of AD by restoring gut-brain homeostasis. This chapter provides an overview of the gut microbiota and its dysregulation in etiology of AD. Moreover, novel insights into alteration of the composition of gut microbiota as a preventive or therapeutic approach to AD are discussed.

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