International review of neurobiology最新文献_第10页

Cannabidiol: Pharmacodynamics and pharmacokinetic in the context of neuropsychiatric disorders. 大麻二酚：神经精神疾病的药效学和药代动力学。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-07-03 DOI: 10.1016/bs.irn.2024.05.001

Pedro H C Lirio, Priscyla D M Gaspari, Alline C Campos

{"title":"Cannabidiol: Pharmacodynamics and pharmacokinetic in the context of neuropsychiatric disorders.","authors":"Pedro H C Lirio, Priscyla D M Gaspari, Alline C Campos","doi":"10.1016/bs.irn.2024.05.001","DOIUrl":"https://doi.org/10.1016/bs.irn.2024.05.001","url":null,"abstract":"In this chapter we explored the growing interest in cannabinoids, particularly cannabidiol (CBD), over the last two decades due to their potential therapeutic applications in neurodegenerative and psychiatric disorders. CBD, a major non-psychotomimetic compound derived from Cannabis sativa, is highlighted as a safer alternative to other cannabinoids like Δ9-tetrahydrocannabinol (THC). Clinical trials have been investigating CBD formulations for conditions such as schizophrenia, multiple sclerosis, Alzheimer's, Parkinson's diseases, and stress-related disorders. However, limited access to CBD-approved formulations primarily due to their high-cost and concerns about the quality of market-available products, challenges regulatory agencies globally. The pharmacokinetics of CBD, especially after oral administration, present challenges with erratic absorption and low bioavailability. CBD's \"promiscuous\" pharmacodynamics involve interactions with various targets beyond the endocannabinoid system, complicating precise dosing in therapeutic interventions. This chapter delves into CBD's dose-response curves, revealing complexities that pose challenges in clinical practice. Nanobiotechnology emerges as a promising solution, with recent developments showing improved bioavailability, stability, and reduced toxicity through nanoencapsulation of CBD. While this phytocannabinoid holds immense promise in neuropsychopharmacology, we provided a comprehensive overview of the current state of CBD research and suggests potential future directions regarding the pharmacology of CBD, harnessing the benefits of this intriguing compound.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"177 ","pages":"11-27"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol in anxiety disorders: Current and future perspectives. 焦虑症中的大麻二酚：当前和未来展望。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-07-02 DOI: 10.1016/bs.irn.2024.05.003

João Luís Queiroz Simei, José Diogo Ribeiro de Souza, João Roberto Lisboa, Francisco Silveira Guimarães, José Alexandre de Souza Crippa

{"title":"Cannabidiol in anxiety disorders: Current and future perspectives.","authors":"João Luís Queiroz Simei, José Diogo Ribeiro de Souza, João Roberto Lisboa, Francisco Silveira Guimarães, José Alexandre de Souza Crippa","doi":"10.1016/bs.irn.2024.05.003","DOIUrl":"https://doi.org/10.1016/bs.irn.2024.05.003","url":null,"abstract":"Anxiety disorders are highly prevalent psychiatric disorders, characterized by a chronic course and often accompanied by comorbid symptoms that impair functionality and decrease quality of life. Despite advances in basic and clinical research in our understanding of these disorders, currently available pharmacological options are associated with limited clinical benefits and side effects that frequently lead to treatment discontinuation. Importantly, a significant number of patients do not achieve remission and live with lifelong residual symptoms that limit daily functioning. Since the 1970s, basic and clinical research on cannabidiol (CBD), a non-psychotomimetic compound found in the Cannabis sativa plant, has indicated relevant anxiolytic effects, garnering attention for its therapeutic potential as an option in anxiety disorder treatment. This chapter aims to review the history of these studies on the anxiolytic effects of CBD within the current understanding of anxiety disorders. It highlights the most compelling current evidence supporting its anxiolytic effects and explores future perspectives for its clinical use in anxiety disorders.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"177 ","pages":"205-234"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol effects on fear processing and implications for PTSD: Evidence from rodent and human studies. 大麻二酚对恐惧处理的影响以及对创伤后应激障碍的影响：来自啮齿动物和人类研究的证据。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-07-02 DOI: 10.1016/bs.irn.2024.03.007

Sabrina Francesca Lisboa, Cristina Aparecida Jark Stern, Lucas Gazarini, Leandro José Bertoglio

{"title":"Cannabidiol effects on fear processing and implications for PTSD: Evidence from rodent and human studies.","authors":"Sabrina Francesca Lisboa, Cristina Aparecida Jark Stern, Lucas Gazarini, Leandro José Bertoglio","doi":"10.1016/bs.irn.2024.03.007","DOIUrl":"10.1016/bs.irn.2024.03.007","url":null,"abstract":"Cannabidiol (CBD) modulates aversive memory and its extinction, with potential implications for treating anxiety- and stress-related disorders. Here, we summarize and discuss scientific evidence showing that CBD administered after the acquisition (consolidation) and retrieval (reconsolidation) of fear memory attenuates it persistently in rats and mice. CBD also reduces fear expression and enhances fear extinction. These effects involve the activation of cannabinoid type-1 (CB1) receptors in the dorsal hippocampus, bed nucleus of stria terminalis, and medial prefrontal cortex, comprising the anterior cingulate, prelimbic, and infralimbic subregions. Serotonin type-1A (5-HT1A) receptors also mediate some CBD effects on fear memory. CBD effects on fear memory acquisition vary, depending on the aversiveness of the conditioning procedure. While rodent findings are relatively consistent and encouraging, human studies investigating CBD's efficacy in modulating aversive/traumatic memories are still limited. More studies are needed to investigate CBD's effects on maladaptive, traumatic memories, particularly in post-traumatic stress disorder patients.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"177 ","pages":"235-250"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical neurophysiology of neuropathic pain. 神经性疼痛的临床神经生理学。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-11-04 DOI: 10.1016/bs.irn.2024.10.005

Michèle Hubli, Caterina Leone

{"title":"Clinical neurophysiology of neuropathic pain.","authors":"Michèle Hubli, Caterina Leone","doi":"10.1016/bs.irn.2024.10.005","DOIUrl":"https://doi.org/10.1016/bs.irn.2024.10.005","url":null,"abstract":"Timely and accurate diagnosis of neuropathic pain is critical for optimizing therapeutic outcomes and minimizing treatment delays. According to current standards, the diagnosis of definite neuropathic pain requires objective confirmation of a lesion or disease affecting the somatosensory nervous system. This can be provided by specialized neurophysiological techniques as conventional methods like nerve conduction studies and somatosensory evoked potentials may not be sufficient as they do not assess pain pathways. These specialized techniques apply various stimuli, such as thermal, electrical, or mechanical, alongside assessments of spinal/cortical potential or electromyographic reflex recordings. The selection of techniques is guided by the patient's clinical history and examination. The most common neurophysiological tests used in clinical practice are pain-related evoked potentials (PREPs) providing an objective evaluation of nociceptive pathways. Four types of PREPs are employed: laser evoked potentials, contact-heat evoked potentials, intra-epidermal electrical stimulation evoked potentials, and pinprick evoked potentials, with the two former ones being the most robust and reliable ones. These techniques investigate small-diameter fibers, primarily Aδ-fibers, and spinothalamic tracts allowing the identification of peripheral or central nervous system lesions. Yet, they are limited in capturing neuronal mechanisms underlying neuropathic pain or in providing objective quantification of pain sensation. Two neurophysiological measures which investigate the pain system beyond its integrity are the nociceptive withdrawal reflex and the N13 component of somatosensory evoked potentials. Both of these methods are more commonly used in research than clinical practice, but they pose interesting approaches to quantify central sensitization, a key underlying mechanism of neuropathic pain. Future investigations in neuropathic pain are therefore warranted.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"179 ","pages":"125-154"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of CBD in Autism Spectrum Disorder. CBD 对自闭症谱系障碍的治疗潜力。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-06-29 DOI: 10.1016/bs.irn.2024.05.002

João F C Pedrazzi, Lucas Hassib, Frederico R Ferreira, Jaime C Hallak, Elaine Del-Bel, José A Crippa

{"title":"Therapeutic potential of CBD in Autism Spectrum Disorder.","authors":"João F C Pedrazzi, Lucas Hassib, Frederico R Ferreira, Jaime C Hallak, Elaine Del-Bel, José A Crippa","doi":"10.1016/bs.irn.2024.05.002","DOIUrl":"https://doi.org/10.1016/bs.irn.2024.05.002","url":null,"abstract":"Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by persistent deficits in social communication and interaction, as well as restricted and repetitive patterns of behavior. Despite extensive research, effective pharmacological interventions for ASD remain limited. Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa plant, has potential therapeutic effects on several neurological and psychiatric disorders. CBD interacts with the endocannabinoid system, a complex cell-signaling system that plays a crucial role in regulating various physiological processes, maintaining homeostasis, participating in social and behavioral processing, and neuronal development and maturation with great relevance to ASD. Furthermore, preliminary findings from clinical trials indicate that CBD may have a modulatory effect on specific ASD symptoms and comorbidities in humans. Interestingly, emerging evidence suggests that CBD may influence the gut microbiota, with implications for the bidirectional communication between the gut and the central nervous system. CBD is a safe drug with low induction of side effects. As it has a multi-target pharmacological profile, it becomes a candidate compound for treating the central symptoms and comorbidities of ASD.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"177 ","pages":"149-203"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing and testing treatments for alcohol use disorder. 设计和测试酒精使用障碍的治疗方法。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.1016/bs.irn.2024.02.004

Katie Witkiewitz, Felicia R Tuchman

引用次数: 0

Executive dysfunction and cognitive decline, a non-motor symptom of Parkinson's disease captured in animal models. 在动物模型中捕捉帕金森病的非运动症状--执行功能障碍和认知能力下降。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2023-12-28 DOI: 10.1016/bs.irn.2023.12.001

Mahmoud M Iravani, Mohammed Shoaib

引用次数: 0

Macro and micro-sleep dysfunctions as translational biomarkers for Parkinson's disease. 作为帕金森病转化生物标志物的宏观和微观睡眠功能障碍。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2023-12-01 DOI: 10.1016/bs.irn.2023.08.008

Marcelo M S Lima, Adriano D S Targa, Gustavo Z Dos Santos Lima, Clarissa F Cavarsan, Pablo Torterolo

{"title":"Macro and micro-sleep dysfunctions as translational biomarkers for Parkinson's disease.","authors":"Marcelo M S Lima, Adriano D S Targa, Gustavo Z Dos Santos Lima, Clarissa F Cavarsan, Pablo Torterolo","doi":"10.1016/bs.irn.2023.08.008","DOIUrl":"10.1016/bs.irn.2023.08.008","url":null,"abstract":"Sleep disturbances are highly prevalent among patients with Parkinson's disease (PD) and often appear from the early-phase disease or prodromal stages. In this chapter, we will discuss the current evidence addressing the links between sleep dysfunctions in PD, focusing most closely on those data from animal and mathematical/computational models, as well as in human-based studies that explore the electrophysiological and molecular mechanisms by which PD and sleep may be intertwined, whether as predictors or consequences of the disease. It is possible to clearly state that leucine-rich repeat kinase 2 gene (LRRK2) is significantly related to alterations in sleep architecture, particularly affecting rapid eye movement (REM) sleep and non-REM sleep, thus impacting sleep quality. Also, decreases in gamma power, observed after dopaminergic lesions, correlates negatively with the degree of injury, which brings other levels of understanding the impacts of the disease. Besides, abnormal synchronized oscillations among basal ganglia nuclei can be detrimental for information processing considering both motor and sleep-related processes. Altogether, despite clear advances in the field, it is still difficult to definitely establish a comprehensive understanding of causality among all the sleep dysfunctions with the disease itself. Although, certainly, the search for biomarkers is helping in shortening this road towards a better and faster diagnosis, as well as looking for more efficient treatments.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"174 ","pages":"187-209"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Animal models for studying therapeutic targets and treatments for alcohol use disorder. 研究酒精使用障碍治疗目标和治疗方法的动物模型。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-10-24 DOI: 10.1016/bs.irn.2024.08.004

Cristiane Aparecida Favoretto, Thamires Righi, Gustavo Juliate Damaceno Fernandes, Natalia Bonetti Bertagna, Ben Tagami Rodolpho, Nilma do Rocio Lara de Lima Janisset, Caio Jovita-Farias, Giovanna Victória Lopes Costa, Alexia Dos Anjos-Santos, Fernando Bezerra Romualdo da Silva, Rodrigo Molini Leão, Fábio Cardoso Cruz

{"title":"Animal models for studying therapeutic targets and treatments for alcohol use disorder.","authors":"Cristiane Aparecida Favoretto, Thamires Righi, Gustavo Juliate Damaceno Fernandes, Natalia Bonetti Bertagna, Ben Tagami Rodolpho, Nilma do Rocio Lara de Lima Janisset, Caio Jovita-Farias, Giovanna Victória Lopes Costa, Alexia Dos Anjos-Santos, Fernando Bezerra Romualdo da Silva, Rodrigo Molini Leão, Fábio Cardoso Cruz","doi":"10.1016/bs.irn.2024.08.004","DOIUrl":"https://doi.org/10.1016/bs.irn.2024.08.004","url":null,"abstract":"Over the decades, preclinical models have been developed and refined to investigate the rewarding effects of addictive substances and the neurobiological underpinnings of alcohol and other drug use disorders. This chapter delves into the methodological foundations, advantages, and limitations of leading animal models used to study alcohol use disorders (AUDs). Some models focus on the early stages of alcohol use and abuse. For instance, conditioned place preference assesses associative learning between a specific context and the effects of the drug, while locomotor sensitization measures increased locomotor activity following repeated drug exposure. In contrast, contingent models such as operant and non-operant alcohol self-administration protocols gauge voluntary intake, preference, motivation, and seeking behavior for alcohol solutions among experimental subjects. Additionally, we discuss the chronic intermittent alcohol vapor model, extensively utilized to induce a phenotype resembling dependence through non-contingent inhalation of alcohol vapor, resulting in elevated blood alcohol concentrations. Given the focus on pharmacological treatments for AUDs, we explore how different animal models can be employed to evaluate potential therapies and extrapolate findings to alcohol-related behaviors in humans. This chapter aims to provide readers with a comprehensive understanding of various animal models for AUDs, aiding in the interpretation of preclinical studies and the selection of suitable models for future research endeavors.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"178 ","pages":"355-381"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroanatomy of the nociceptive system: From nociceptors to brain networks. 痛觉系统的神经解剖学：从痛觉感受器到大脑网络。

International review of neurobiology Pub Date : 2024-01-01 Epub Date: 2024-11-04 DOI: 10.1016/bs.irn.2024.10.008

Julian C Motzkin, Allan I Basbaum, Andrew J Crowther

引用次数: 0