International review of neurobiology最新文献_第2页

Potential therapeutic effects of psychedelics in small doses: Is there a role for microdosing in psychiatry? 小剂量致幻剂的潜在治疗效果：微剂量在精神病学中有作用吗？

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-04-02 DOI: 10.1016/bs.irn.2025.03.002

Iva Totomanova, Eline C H M Haijen, Petra P M Hurks, Johannes G Ramaekers, Kim P C Kuypers

{"title":"Potential therapeutic effects of psychedelics in small doses: Is there a role for microdosing in psychiatry?","authors":"Iva Totomanova, Eline C H M Haijen, Petra P M Hurks, Johannes G Ramaekers, Kim P C Kuypers","doi":"10.1016/bs.irn.2025.03.002","DOIUrl":"https://doi.org/10.1016/bs.irn.2025.03.002","url":null,"abstract":"Clinical trials using full doses of psychedelics have provided preliminary evidence supporting their safety and efficacy in treating a variety of physical and psychological conditions. Anecdotal reports indicate that even very small amounts of these substances may provide therapeutic benefits, though robust clinical studies are still needed. This chapter reviews the current experimental studies in humans using psychedelics in small doses to better understand their therapeutic potential. Research in both neurotypical individuals (n = 18 studies) and patients (n = 3) suggests that small doses of LSD and psilocybin produce subtle, acute, effects on neural connectivity, brain electrophysiology, blood pressure, sleep duration, pain perception, temporal processing, and mood; and show reductions in symptoms of depression and obsessive-compulsive behavior in patient samples. The chapter also discusses the influence of extra-pharmacological factors, such as the baseline subjective state, expectations, and individual differences in drug metabolism, on treatment outcomes. Overall, controlled microdosing studies suggest the potential therapeutic applications of small psychedelic doses, warranting further exploration through large-scale trials in clinical populations.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"181 ","pages":"231-268"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychedelics for the treatment of end-of-life distress in patients with a life-threatening disease. 致幻剂用于治疗生命垂危疾病患者的临终痛苦。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-04-22 DOI: 10.1016/bs.irn.2025.03.001

Stephan Tap, Tijmen Bostoen, Joost Breeksema, Robert Schoevers

{"title":"Psychedelics for the treatment of end-of-life distress in patients with a life-threatening disease.","authors":"Stephan Tap, Tijmen Bostoen, Joost Breeksema, Robert Schoevers","doi":"10.1016/bs.irn.2025.03.001","DOIUrl":"https://doi.org/10.1016/bs.irn.2025.03.001","url":null,"abstract":"Patients with a life-threatening disease (LTD) sometimes suffer from end-of-life distress (EOLD) which refers to the physical, psychological, emotional, and spiritual suffering related to chronic illness and the possibility of death. Palliative care interventions seek to improve the quality of life of patients with EOLD and their significant others. Currently, a range of psychological and pharmacological palliative care interventions may be used to mitigate the various symptoms related to EOLD. However, the evidence for their efficacy is inconclusive with only short- to moderate effects. Another significant and relevant limitation in the context of LTDs is that palliative care interventions often require months to take effect. In the past decade, psychedelic-assisted therapy (PAT) has been increasingly investigated for its therapeutic potential in addressing EOLD in various LTDs characterized by highly significant and sometimes sustained decreases in symptoms of depression and (death) anxiety along with other EOLD-related improvements (e.g., meaning, spiritual well-being, optimism, life satisfaction, and change attitudes towards LTDs). The current chapter will provide a detailed description of the concept of EOLD followed by estimated prevalence rates in a range of LTDs. Next, the chapter provides a brief overview of palliative interventions and their limitations. The chapter then introduces a description of PAT, its evidence-base, and why it seems to work in particular for patients with EOLD. The chapter is concluded with future perspectives.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"181 ","pages":"357-393"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral agents in neuromuscular pathology. 神经肌肉病理学中的病毒因子。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-05-05 DOI: 10.1016/bs.irn.2025.04.007

Abhay Kumar Singh, Yemgadda Goutham Sudhan, Ramakrisha Ramakrishna, Siva Sundara Kumar Durairajan

{"title":"Viral agents in neuromuscular pathology.","authors":"Abhay Kumar Singh, Yemgadda Goutham Sudhan, Ramakrisha Ramakrishna, Siva Sundara Kumar Durairajan","doi":"10.1016/bs.irn.2025.04.007","DOIUrl":"https://doi.org/10.1016/bs.irn.2025.04.007","url":null,"abstract":"In recent years, viral infections have been increasingly identified as major players in neuromuscular pathologies. This chapter presents an overview of the evidence and future directions for virus-induced neuromuscular disorders. Information is integrated on the global burden of these diseases related to epidemiology, clinical features, diagnosis, treatment, and preventive strategies was integrated. Responsible viruses include enteroviruses, flaviviruses, herpesviruses, and emerging pathogens such as SARS-CoV-2. It represents a broad spectrum of neuromuscular disorders, including Guillain-Barré syndrome, viral myositis, and critical illness neuropathy/myopathy. The book chapter discusses different diagnostic approaches, therapy strategies, and rehabilitation methods, in addition to early intervention and preventive measures. This has led to new insights into novel therapies, unmet research needs, and future perspectives on viral neuromuscular disorders. This chapter demonstrates that supporting both clinical care and patient management with clinical research entails a profound understanding of the difficult interactions between the viruses concerned and the neuromuscular system.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"180 ","pages":"397-434"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial meningitis is a significant catalyst for neuroinflammation. 细菌性脑膜炎是神经炎症的重要催化剂。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-04-15 DOI: 10.1016/bs.irn.2025.03.010

Sudharsan Parthasarathy, Siva Vijayakumar Tharumasivam, Ashajyothi Chavaan, Bupesh Giridharan, Archana Sundaram

{"title":"Bacterial meningitis is a significant catalyst for neuroinflammation.","authors":"Sudharsan Parthasarathy, Siva Vijayakumar Tharumasivam, Ashajyothi Chavaan, Bupesh Giridharan, Archana Sundaram","doi":"10.1016/bs.irn.2025.03.010","DOIUrl":"https://doi.org/10.1016/bs.irn.2025.03.010","url":null,"abstract":"Bacterial meningitis is a severe infection that can lead to neuroinflammation, posing risks to the central nervous system (CNS). This inflammation, if uncontrolled, can cause long-term neurological damage, cognitive decline, and neuron injury. Management strategies include telemedicine and remote monitoring, enabling continuous observation and timely adjustments in treatment. Early detection through biosensor technology is vital, offering healthcare providers insights for proactive intervention before critical issues arise. Nutritional support, particularly hydration, is also emphasized to strengthen immune response and potentially delay disease progression. The chapter highlights the transformative potential of Artificial Intelligence (AI) and machine learning in disease management, from prognostic assessments to creating personalized treatment plans. By integrating AI-driven insights with advanced monitoring and preventive approaches, healthcare providers can mitigate the impact of bacterial meningitis, enhancing patient outcomes and recovery potential.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"180 ","pages":"369-396"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disruption in the human microbiome causing behavioural changes in bipolar disorder. 人类微生物群的破坏导致双相情感障碍的行为改变。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-04-15 DOI: 10.1016/bs.irn.2025.04.001

Subramani Srinivasan

引用次数: 0

Serotonin, immune function, and psychedelics as potent anti-inflammatories. 血清素，免疫功能，和迷幻药作为有效的抗炎药。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-04-21 DOI: 10.1016/bs.irn.2025.04.011

Charles D Nichols, Timothy P Foster

{"title":"Serotonin, immune function, and psychedelics as potent anti-inflammatories.","authors":"Charles D Nichols, Timothy P Foster","doi":"10.1016/bs.irn.2025.04.011","DOIUrl":"https://doi.org/10.1016/bs.irn.2025.04.011","url":null,"abstract":"Psychedelics are primarily recognized for their profound behavioral effects, leading most research on psychedelics and their primary target, the 5-HT2A receptor, to focus on brain activity. However, these receptors are not only found within the brain and are present in nearly every tissue and cell type throughout the body, playing a significant role alongside serotonin in modulating various processes, including immune function. Serotonin acting at 5-HT2A receptors generally promotes inflammation. Levels are elevated at sites of inflammation and through 5-HT2A receptor activation lead to events including increased cytokine production, eosinophil recruitment, T-cell activation, and mast cell degranulation. Some psychedelics, but not all, have been found to have powerful anti-inflammatory and immunomodulatory effects through activation of 5-HT2A receptors in preclinical experimental systems and models of human inflammatory diseases. Human studies examining anti-inflammatory effects of psychedelics are limited but suggestive that psychedelics may represent a new strategy to treat inflammatory diseases. In this review we will present an overview of serotonergic modulation of immune function, the role of 5-HT2A receptors in these processes, and a summary of key findings with psychedelics with regards to anti-inflammatory efficacy.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"181 ","pages":"45-76"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serotonergic psychedelics for depression: A comprehensive overview. 5 -羟色胺类致幻剂治疗抑郁症：综合综述。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-05-14 DOI: 10.1016/bs.irn.2025.04.009

A M Wingert, C Agnorelli, J Peill, S Reed, D J Nutt, D Erritzoe

{"title":"Serotonergic psychedelics for depression: A comprehensive overview.","authors":"A M Wingert, C Agnorelli, J Peill, S Reed, D J Nutt, D Erritzoe","doi":"10.1016/bs.irn.2025.04.009","DOIUrl":"https://doi.org/10.1016/bs.irn.2025.04.009","url":null,"abstract":"Depressive disorders continue to pose a major clinical challenge worldwide, particularly given the high prevalence and increasing number of treatment-resistant cases. Over the past decade, advances in research have elucidated the antidepressant potential of psilocybin and other 5-HT₂A receptor agonists in patients with major depressive disorder (MDD) and treatment-resistant depression (TRD). Phase I and II clinical trials have consistently demonstrated that even a single administration can yield rapid and sustained symptom reduction. These effects compare favourably with conventional pharmacotherapies such as SSRIs and ketamine. The distinctive pharmacological profile and robust safety data associated with serotonergic psychedelics make them particularly promising candidates, especially for patients who do not respond to standard treatments. Nonetheless, several challenges impede their integration into routine clinical practice, including the resource-intensive nature of psychedelic-assisted therapy, which demands specialized training and controlled settings. Despite those limitations, some countries including Australia, Switzerland or Canada are paving the way by allowing the use of psilocybin in TRD cases. This chapter reviews the antidepressant potential of psilocybin, DMT, ayahuasca and 5-MeO-DMT based on modern clinical trial data, comparing effect sizes of psychedelics to conventional treatments like SSRIs and ketamine, and provides a brief overview of their potential neurobiological mechanisms.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"181 ","pages":"271-304"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered microbiome influence on the enteric neuromuscular system in amyotrophic lateral sclerosis (ALS). 肌萎缩性侧索硬化症（ALS）患者肠道神经肌肉系统微生物组改变的影响。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-05-16 DOI: 10.1016/bs.irn.2025.04.006

Sadari Manusha, N Varsha, R Varshini, Yuvaraj Sivamani, Kiran Sree Pokkuluri, Sumitha Elayaperumal

引用次数: 0

Dysbiosis significantly elevates the probability of altered affective function in Alzheimer disease (AD). 生态失调显著提高阿尔茨海默病（AD）患者情感功能改变的可能性。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-05-03 DOI: 10.1016/bs.irn.2025.04.005

Harsh Kumar, Daljeet Singh Dhanjal, Rajni Dhalaria, Neetika Kimta, Richard Cimler, Kamil Kuča

引用次数: 0

Human neuroimaging: fMRI. 人类神经成像：功能磁共振成像。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-06-06 DOI: 10.1016/bs.irn.2025.04.013

Matthew B Wall, Robin L Carhart-Harris

{"title":"Human neuroimaging: fMRI.","authors":"Matthew B Wall, Robin L Carhart-Harris","doi":"10.1016/bs.irn.2025.04.013","DOIUrl":"https://doi.org/10.1016/bs.irn.2025.04.013","url":null,"abstract":"Human neuroimaging with functional Magnetic Resonance Imaging has been a key feature of the current wave of psychedelic research, in both healthy and clinical populations. The available data has suggested that classic psychedelics (psilocybin, LSD, DMT) have a characteristic effect of acutely and profoundly disrupting the normal pattern of resting-state connectivity in the human brain, and that this effect may be closely related to both the characteristic subjective phenomenology of psychedelics, and their more clinically-relevant longer-term effects on emotional brain systems. This chapter briefly outlines the basic methodological background of fMRI, and then provides an overview of the current state of knowledge of psychedelic drug action as revealed by task and resting-state fMRI, in both non-clinical and clinical cohorts. Current limitations of the field are largely addressable by ongoing and future work, particularly in terms of providing additional datasets, increased standardisation of data acquisition and analysis procedures, potential multi-modal imaging studies, and more open data-sharing. Neuroimaging with fMRI remains a central platform of modern psychedelic research, with implications for our mechanistic understanding of psychedelics, as well as a strong influence on the clinical development of psychedelic-based treatments.","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"181 ","pages":"149-170"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0