International journal of radiation biology最新文献

{"title":"N-acetyl-L-tryptophan provides radioprotection to mouse and primate models by antagonizing the TRPV1 receptor and substance P inhibition.","authors":"Raj Kumar, Pratibha Kumari, Neelanshu Gaurav, Ravi Kumar, Darshana Singh, Poonam Malhotra, Shravan Kumar Singh, Rabi Sankar Bhatta, Anil Kumar, Perumal Nagarajan, Surender Singh, Nishu Dalal, Bal Gangadhar Roy, Anant Narayan Bhatt, Sudhir Chandna","doi":"10.1080/09553002.2024.2435330","DOIUrl":"10.1080/09553002.2024.2435330","url":null,"abstract":"<p><strong>Purpose: </strong>The present study was carried out to evaluate the radioprotective activities of N-acetyl-L-tryptophan (L-NAT) using rodent and non-human primate (NHP) models.</p><p><strong>Materials and methods: </strong>The antagonistic effect of L-NAT on the Transient receptor potential vanilloid-1 (TRPV1) receptor and substance P inhibition was determined using molecular docking and Elisa assays. The in <i>vivo</i> radioprotective activity of L-NAT was evaluated using whole-body survival assays in mice and NHPs. Radioprotective activity of L-NAT was also determined at the systemic level using quantitative histological analysis of bone marrow, jejunum, and seminiferous tubules of irradiated mice.</p><p><strong>Results: </strong>Molecular docking studies revealed a strong binding of L-NAT with TRPV1 receptor at similar binding pockets to which capsaicin, an agonist of the TRPV1 receptor, binds. Further, capsaicin and gamma radiation were found to induce substance P levels in the intestines and serum of the mice, while L-NAT pretreatment was found to inhibit it. Significant whole-body survival (>80%) was observed in irradiated (9.0 Gy) mice that pretreated with L-NAT (150 mg/kg, b.wt. im) compared to 0% survival in irradiated mice that not pretreated with L-NAT. The quantitative histology of the hematopoietic, gastrointestinal, and male reproductive systems demonstrated significant protection against radiation-induced cellular degeneration. Interestingly, 100% survival was observed with irradiated NHPs (6.5 Gy) that pretreated with L-NAT (37.5 mg/kg, b.wt.im). Significant improvement in the hematology profile was observed after days 10-20 post-treatment periods in irradiated (6.5 Gy) NHPs that were pretreated with L-NAT.</p><p><strong>Conclusion: </strong>L-NAT demonstrated excellent radioprotective activity in the mice and NHP models, probably by antagonizing TRPV1 receptor and subsequently inhibiting substance P expression.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"118-143"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbeam radiation therapy for lung cancer: a review of experimental setups and biological endpoints in preclinical studies.","authors":"Abbie Reynolds, Laure Marignol","doi":"10.1080/09553002.2025.2473981","DOIUrl":"10.1080/09553002.2025.2473981","url":null,"abstract":"<p><strong>Background: </strong>Microbeam radiation therapy (MRT) seeks to improve the therapeutic ratio of conventional radiation therapy though the delivery of high doses in micrometre-scale beamlets of synchrotron-generated X-rays.</p><p><strong>Purpose: </strong>To assess the MRT experimental setups and biological endpoints used in preclinical studies investigating its therapeutic potential in lung cancer models.</p><p><strong>Methodology: </strong>PubMed, Embase, Science Direct, and Web of Science were searched using the following keywords, 'microbeam', 'micro beam', 'synchrotron' and 'lung'. The reported physical parameters of the MRT set up and biological endpoints chosen to test efficacy were examined.</p><p><strong>Main findings: </strong>Fourteen studies were assessed. The microbeam widths ranged from 25 µm to 630 µm, and the microbeam spacing ranged from 0 µm to 4000 µm. The peak doses ranged up to 1000 Gy and dose rates ranged from 4 Gy/s to 1.4x10⁴ Gy/s. Fibrosis was the most commonly assessed radiation-induced toxicity.</p><p><strong>Conclusion: </strong>MRT experimental set ups and biological endpoints are heterogeneous. Standardization could strengthen future evidence supporting its use for the management of patients with lung cancer.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"549-558"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of pre-radiation exposure on physiological and fermentation activity of <i>Saccharomyces cerevisiae</i> SAF Ale S-33.","authors":"Emmanuel Kormla Danyo, Maria Igorevna Tokareva, Ruslan Albertovich Vazirov, Irina Stanislavovna Selezneva","doi":"10.1080/09553002.2025.2498979","DOIUrl":"10.1080/09553002.2025.2498979","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate the effect of radiation pre-exposure on the survival, physiological, and fermentation activity of <i>Saccharomyces cerevisiae</i>.</p><p><strong>Materials and methods: </strong>The low-dose (20-80 cGy) irradiation was conducted using the medical therapy installation Xstrahl 320, which has a maximum energy of 320 keV and a dose rate of 1 Gy/min. High-dose (1 and 5 kGy) exposure was achieved by an electron beam using the linear accelerator UELR-10-10S with a maximum energy of 10 MeV and a dose rate of 1 kGy/s.</p><p><strong>Results: </strong>The results showed that hyper-radiosensitivity of the yeast exposed to low-dose radiation occurred at 20 cGy and induced radio-resistance occurred at doses from 40 to 60 cGy, increasing survival. The pre-exposure of <i>S. cerevisiae</i> to 60 cGy radiation conferred adaptation on the yeast to withstand repeated exposure to a higher dose (1 kGy). The irradiation of <i>S. cerevisiae</i> with low doses ranging from 20 to 80 cGy decreased its physiological and metabolic activity compared to the non-irradiated yeast samples. The viability of the yeast was totally lost after exposure to 5 kGy, resulting in the death of all the yeast.</p><p><strong>Conclusions: </strong>The pre-exposure of <i>S. cerevisiae</i> to radiation resulted in a decline in growth, vitality, metabolic activity, and fermentation activity. However, pre-exposure of the yeast to low-dose radiation (40 and 60 cGy) induced an adaptive response, reducing the damaging effect usually experienced from high-dose (kGy) exposure.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"742-750"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages of single high-dose radiation therapy compared with conventional fractionated radiation therapy in overcoming radioresistance.","authors":"Yun-Suk Kwon, Phuong Anh Nguyen, Hai Yen Dao, Hyunsoo Jang, Soyoung Kim","doi":"10.1080/09553002.2024.2418493","DOIUrl":"10.1080/09553002.2024.2418493","url":null,"abstract":"<p><strong>Background: </strong>Radioresistance is a major clinical challenge in cancer treatment, as it reduces the effectiveness of radiation therapy (RT). While advances in radiation delivery have enabled the clinical use of high-dose hypofractionated RT, its impact on radioresistant tumors remains unclear. This study aimed to compare the effects of single high-dose RT with conventional fractionated RT on radioresistant breast cancer cells and explore the underlying mechanisms.</p><p><strong>Methods: </strong>Radioresistant cell lines were previously established by exposing SK-BR-3 and MCF-7 cells to 48 Gy and 70 Gy of radiation, respectively, in multiple fractions. We compared the effects of 2 Gy × 5 and 7 Gy × 1 fractions on these cells using clonogenic survival assays and western blot analysis. In vivo antitumor effects were assessed in SR tumor-bearing <i>BALB/c</i> mice irradiated with either 2 Gy × 5 or 7 Gy × 1 fractions.</p><p><strong>Results: </strong>7 Gy x1 was more efficient at killing radioresistant breast cancer cells than 2 Gy x5. Furthermore, the 7 Gy x1 fraction produced higher levels of reactive oxygen species (ROS) and decreased the expression of radioresistance factors such as p-STAT3, ACSL4, FOXM1, RAD51, Bcl-xL, and survivin. Consistent with the in vitro studies, the 7 Gy × 1 fraction also showed superior antitumor effects in SR tumor-bearing <i>BALB/c</i> mice.</p><p><strong>Conclusions: </strong>Single high-dose RT offers superior advantages over conventional fractionated RT in regard to overcoming radioresistance, supporting its potential as a promising treatment for recurrent tumors.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"44-55"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and characterization of gamma rays induced mutants for improved agro-morphological performance and harder grain texture in wheat (<i>Triticum aestivum</i> L.).","authors":"Amit Rana, Vijay Rana, Suman Bakshi, Vinod Kumar Sood","doi":"10.1080/09553002.2024.2425305","DOIUrl":"10.1080/09553002.2024.2425305","url":null,"abstract":"<p><strong>Purpose: </strong>Kernel texture plays a principal role in determining technological flour properties and end-use quality of wheat products. Hence, a multi-year mutation induction programme was conducted to isolate advanced wheat mutant lines with agro-morphologically superior performance, higher disease resistance and harder grain texture.</p><p><strong>Materials and methods: </strong>Radiation mutagenesis was employed in soft textured wheat variety HPW 89 using gamma rays dose of 250, 300 and 350 Gy (Co⁶⁰: BARC, Mumbai) and evaluated across M_1-5 generations. Promising superior mutants selected were evaluated during M₄ and M₅ generation for induced variability and trait association for agro-morphological and quality traits. The screened mutants were also determined for induced changes at genetic level using gene specific markers for puroindoline genes.</p><p><strong>Results: </strong>A total of 293 agro-morphologically superior mutants isolated showed significant genetic variation in the M₄ generation. Single kernel characterization system categorized 267 mutants (8.79-50.06) with higher grain hardness than the HPW 89 variety (7.39). Among these, 108 mutants were selected for agro-morphological and molecular characterization. Significant variations were found in these mutants in either <i>pina</i> and <i>pinb</i> or both puroindoline genes. Clustering among these mutants led to the formation of five clusters and a total of eleven mutants were found with better set of agro-morphological, disease resistance and quality traits.</p><p><strong>Conclusion: </strong>These mutants can serve as important genetic resource for developing harder texture bread wheat varieties in the future grain quality improvement programmes. These mutants will also bridge the need of bakers and millers' requirement of varieties with specific texture and quality.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"85-100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of gamma irradiation treatments on the germination, moisture, viability and radicle length of <i>Quercus frainetto</i> acorns.","authors":"Servet Caliskan, Vedat Aslan, Mesut Tandoğan, Mehmet Özdemir, Safa Balekoglu","doi":"10.1080/09553002.2025.2470208","DOIUrl":"10.1080/09553002.2025.2470208","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of this study was to ascertain the impact of varying dosages of gamma irradiation on the germination and development of <i>Quercus frainetto</i> acorns.</p><p><strong>Materials and methods: </strong>The acorns were subjected to gamma radiation from a cobalt-60 source at doses of 25, 50, 100, and 200 gray. The germination percentage, mean germination time, and radicle length of the acorns were quantified. Images were used to evaluate the radicle length. Correlation was employed to investigate the relationships between gamma radiation treatments and moisture content, tetrazolium staining, germination percentage, mean germination time, and radicle length.</p><p><strong>Results: </strong>The impact of gamma-ray radiation on acorns was found to significantly affect moisture content, viability, germination percentage, mean germination time, and radicle length. The germination percentage indicated a decline, particularly at 100 Gy. The acorn lots subjected to 25 grays had the highest germination percentage (92%). The germination percentage in the acorn lots treated with 200 grays decreased by approximately half (44%) in comparison to the control (86%), while the radicle length decreased from 14.8 cm to approximately one-tenth (1.4 cm).</p><p><strong>Conclusions: </strong>The findings demonstrated that the germination percentage and radicle length declined with elevated gamma radiation intensity. While low doses of gamma (25 grays) radiation may facilitate germination, higher doses can exert detrimental effects, including the suppression or complete inhibition of germination. The application of gamma treatment has been demonstrated to be an effective method of inhibiting radicle length elongation, a process that is crucial for the storage and postharvest seeding of acorns.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"531-540"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testicular exposure to ionizing radiation and sperm epigenetic alterations as possible mechanisms of hereditary effects: perspectives from the viewpoint of radiation protection.","authors":"Hisanori Fukunaga, Nobuyuki Hamada","doi":"10.1080/09553002.2024.2440860","DOIUrl":"10.1080/09553002.2024.2440860","url":null,"abstract":"<p><strong>Purpose: </strong>Since the genotoxicity of ionizing radiation was demonstrated in the 1920s, its hereditary effects have remained a serious concern for human society. The International Commission on Radiological Protection has highlighted the need for appropriate protection against hereditary effects of radiation in humans. In this paper, we review the literature on the possible multigenerational and transgenerational effects following testicular exposure to radiation, focusing on sperm epigenetic alterations as possible mechanisms.</p><p><strong>Results: </strong>This mini-review highlights that hereditary effects following testicular exposure occur via epigenetic changes of germ cells in animal models, providing implications on human radiation protection.</p><p><strong>Conclusions: </strong>A great amount of epigenomic research data has emerged rapidly since the beginning of this century; thus, a revision of the radiological protection protocols against the hereditary effects of radiation would be no longer inevitable. The collection and analysis of evidence on these effects must be enhanced and further accelerated to formulate appropriate protection protocols in the future.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"101-106"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric impacts on height development after radiotherapy for intracranial non-germinomatous germ cell tumors.","authors":"Guanhua Deng, Juan Li, Zhaoming Zhou, Changguo Shan, Jing He, Mingyao Lai, Ping Zhang, Junjie Zhen, Shaoqun Li, Weiping Hong, Xiaolei Hu, Jie Ding, Linbo Cai, Cheng Zhou, Lei Wen","doi":"10.1080/09553002.2025.2473980","DOIUrl":"10.1080/09553002.2025.2473980","url":null,"abstract":"<p><strong>Objectives: </strong>Intracranial non-germinomatous germ cell tumors (NGGCTs) are rare pediatric central nervous system (CNS) tumors. Growth impairment induced by radiation treatment was rarely evaluated. We aimed to evaluate the impacts of radiotherapy on height development as well as the dosimetric constraints, providing potential insights for hormonal replacement treatment.</p><p><strong>Methods: </strong>A total of 128 pediatric patients diagnosed with NGGCTs were retrospectively studied. Sex, age at irradiation, physical doses and biologically effective dose (BED), height and endocrine status were obtained for analysis. The cumulative change in height was assessed using age-matched normalized height (ANH). Cumulative physical doses and BEDs for the whole brain and pituitary were derived via dose-volume histograms (DVHs) and BED-volume histograms (BEDVHs).</p><p><strong>Results: </strong>For pediatric patients ≤ 11.5 years, linear correlations between ANH and cumulative physical doses as well as BEDs to the whole brain and pituitary were identified. More specifically, dosimetric constraints to the pituitary were 36 Gy for physical dose (AUC = 0.70 [95% CI, 0.54-0.86], <i>p</i> < .05) and 63 Gy₂ BED (AUC = 0.69 [95% CI, 0.53-0.86], <i>p</i> < .05). Impaired hormone secretion with respect to growth hormone (GH) and thyroid-stimulating hormone (TSH) was observed following cranial irradiation (both <i>p</i> < .001), particularly for those with tumors at the suprasellar region (GH: <i>p</i> < .01, TSH: <i>p</i> < .001). Unlikely to patients > 11.5 years, the height development for patients with tumors in the suprasellar region was significantly more affected than those in the other locations (<i>p</i> < .01) among patients ≤11.5 years.</p><p><strong>Conclusions: </strong>Our study revealed the impacts of cumulative doses and tumor locations for radiation-associated growth impairment. Reduced levels of GH and TSH were observed in patients ≤ 11.5 years particularly with tumors in the suprasellar region.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"510-520"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The activation mode of a dirty-bomb can modify the health risk estimation profile.","authors":"Rocco Pascale Neto, Vitor W L Silva, William H S Profeta, Andrew Collinson, Ricardo M Stenders, Rodrigo C Curzio, Hélio C Vital, Edson R Andrade","doi":"10.1080/09553002.2024.2435334","DOIUrl":"10.1080/09553002.2024.2435334","url":null,"abstract":"<p><strong>Purpose: </strong>This study focuses on analytical computer simulations performed to investigate a hypothetical event where the activation of a radiological dispersion device (RDD) triggers a crisis.</p><p><strong>Materials and methods: </strong>The methodology presents steps centered on the initial evaluation phase of the event (initial 100 hours), aiming to evaluate the radiological risks regarding the development of leukemia. Local environmental changes, sex, and age were also used to assess risks.</p><p><strong>Results: </strong>It was also estimated that the sex of potentially affected individuals was irrelevant to decisions at the early phase of the event. In contrast, age and the moment of release (day or night) were the most important variables influencing individual radiological risk.</p><p><strong>Conclusions: </strong>Based on the calculated results, it was possible to conclude that the proposed methodology would significantly contribute to planning the allocation of human resources, reducing future risks.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"215-221"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A chromosome 2 locus influences the onset of radiation-induced lung disease in mice.","authors":"Lisa Honeyman, Marie-Eve Bergeron, Cin Thang, Amit Kunwar, Erin E McCurry, Christina K Haston","doi":"10.1080/09553002.2025.2473977","DOIUrl":"10.1080/09553002.2025.2473977","url":null,"abstract":"<p><strong>Purpose: </strong>The onset of distress from radiation-induced lung disease differs among patients and among inbred strains of mice exposed to thoracic cavity radiotherapy. For the latter specifically, C3H/HeJ mice present distress due to pneumonitis at approximately 10-14 weeks following thoracic irradiation, while C57BL/6J mice show distress due to pneumonitis with pulmonary fibrosis at 22-30 weeks. Mapping studies completed in offspring derived from these inbred strains revealed a chromosome 2 locus to be linked to onset of distress in irradiated mice. Herein, we bred and phenotyped a panel of chromosome 2 subcongenic mice with 64 Mb of C3H/HeJ alleles on a C57BL/6J background, to investigate the contribution of the chromosome 2 locus to radiation-induced lung disease.</p><p><strong>Materials and methods: </strong>Mice received 18 Gy to the thoracic cavity and were monitored for the onset of distress. Lung disease was assessed histologically and with bronchoalveolar lavage.</p><p><strong>Results: </strong>Following whole thorax irradiation, subcongenic mice with C3H/HeJ alleles from 95 to 123 Mb showed significantly earlier onset of respiratory distress (16-22 weeks; <i>p</i> < .02) from pneumonitis and fibrosis compared to C57BL/6J mice. These subcongenic mice did not differ from C57BL/6J mice in pneumonitis (<i>p</i> = .23), mast cell counts (<i>p</i> = .96), or lavage neutrophils (<i>p</i> = .69), evident at distress. <i>In silico</i> analyses reveal 246 protein coding genes mapped within the reduced region, 52 of which differ in pulmonary expression of C3H/HeJ, compared to C57BL/6J, mice after whole thorax irradiation.</p><p><strong>Conclusions: </strong>We have identified a 28 Mb region of chromosome 2 to influence the onset of radiation-induced lung disease in mice.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"581-589"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}