International journal of radiation biology最新文献

{"title":"Synergistic effects of hydropriming and differential gamma radiation on the physiomorphic attributes of <i>Cannabis sativa</i> L.","authors":"Rabeea Tariq, Umer Habib, Muhammad Azam Khan, Rashid Mehmood Rana, Maryam Bibi","doi":"10.1080/09553002.2026.2710766","DOIUrl":"https://doi.org/10.1080/09553002.2026.2710766","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the impact of hydropriming and gamma rays on morpho-functional attributes of <i>Cannabis sativa</i> L. and identified optimal radiation levels for improvements in local hemp germplasm.</p><p><strong>Materials and methods: </strong>Two seed lots, <i>G</i>₁ (pre-irradiation hydropriming) and <i>G</i>₂ (post-irradiation hydropriming), were subjected to the radiation source cobalt-60 (Co⁶⁰) at specified doses (150, 300, 450, and 600 Gy) in a completely randomized factorial experiment with 10 treatments and three replications. Key physiomorphic traits, including germination rate, survival percentage, plant height, leaf number, shoot/root dry weight, trichome traits, chlorophyll and metabolite contents (anthocyanin, flavonoids), were measured and statistically analyzed via ANOVA Tukey's HSD. Regression heat maps and dose response curves were drawn to find out optimal dose levels.</p><p><strong>Results: </strong>Gamma irradiation significantly influenced all the parameters across treatments compared to wild-types. Application @150 Gy increased seed germination, survival rate, plant height, biomass, chlorophyll content, and trichome density while high doses (210.16 Gy in <i>G</i>₁ and 425.95 Gy in <i>G</i>₂) surpassed LD₅₀. Maximum phenotypic variation was observed in <i>G</i>₁<i>D</i>₁ and <i>G</i>₂<i>D</i>₃. The trichome density notably increased at low to moderate doses. A significantly positive correlation was observed among parameters in response to gamma irradiation; however, dose response curves showed greater radio-tolerance and growth in <i>G</i>₂ than <i>G</i>₁ plants.</p><p><strong>Conclusion: </strong>Low-dose gamma irradiation (150 Gy) combined with hydropriming can be an effective mutagenic approach to enhance the growth and biochemical traits of <i>Cannabis sativa</i>. The findings offered a viable mutation protocol to develop improved hemp varieties tailored for fiber and cannabidiol (CBD) production.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-15"},"PeriodicalIF":2.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of a four gene set with H-ARS severity in irradiated minipigs treated with Myelo001.","authors":"Nikolai Schmid, Aleš Tichý, Lenka Lecová, Corinna Asang, Dirk Pleimes, Samantha Stewart, Mandy Kasper, Patrick Ostheim, Stefan Eder, Matthias Port, Michael Abend","doi":"10.1080/09553002.2026.2705996","DOIUrl":"https://doi.org/10.1080/09553002.2026.2705996","url":null,"abstract":"<p><strong>Purpose: </strong>Early prediction of hematological acute radiation syndrome (H-ARS) saves lives. For H-ARS severity prediction, we established a four-gene panel (<i>FDXR, DDB2, POU2AF1</i>, <i>WNT3</i>) using leukemia patients and non-human primates. Further confirmation in 12 minipigs failed, due to a weak response of these genes after irradiation.</p><p><strong>Materials and methods: </strong>Here, we intended to confirm previous findings using a larger cohort (n = 19) and assess the impact of Myelo001 on clinical progression and gene expression. All minipigs received 2.1 Gy total-body irradiation (LD ≈ 40/30). The study included an irradiated control group and two irradiated groups treated with Myelo001 (11 or 15 days). Peripheral blood was collected six days before and on days 1-, 3-, and 10 after irradiation. RNA was isolated, reverse-transcribed, and analyzed by qRT-PCR using TaqMan assays. Differential gene expression (DGE) was calculated relative to pre-irradiation samples.</p><p><strong>Results: </strong><i>WNT3</i> was undetectable in most animals. No significant difference in gene expression, survival, or clinical progression were found between Myelo001-treated and untreated animals, so treatment groups were pooled for DGE analyses. Across all time points, no significant changes in DGE were observed, except for slight <i>DDB2</i> upregulation on day 3 (DGE = 2.3). The expected pattern of upregulated (DGE >2) <i>FDXR</i>/<i>DDB2</i> with simultaneous downregulation (DGE <0.5) of <i>POU2AF1</i>, was absent (except on day one in one minipig). This missing pattern contrasted with an on average 5.5-fold reduction in lymphocyte counts, indicative of severe H-ARS. Also, no age or sex related changes were observed.</p><p><strong>Conclusion: </strong>This independent minipig study confirms previous work showing that these genes do not exhibit statistically significant radiation-responsiveness in this animal model. Under the experimental conditions applied, no significant age or sex related changes nor treatment-related effects of Myelo001 were observed, which may reflect model-specific limitations or a lack of efficacy in this setting, or a combination of both.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-12"},"PeriodicalIF":2.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical targeted alpha therapy of B7-H3-positive tumors using [²²⁵Ac]Ac-Macropa-PEG₂-enoblituzumab via EDC/NHS-mediated conjugation.","authors":"Madeeha Shabnam, Syed Qaiser Shah, Ralph Santos-Oliveira","doi":"10.1080/09553002.2026.2710757","DOIUrl":"https://doi.org/10.1080/09553002.2026.2710757","url":null,"abstract":"<p><strong>Purpose: </strong>Targeted alpha therapy (TAT) has the advantage of localized cytotoxicity using the high linear energy transfer capabilities of alpha particles. Actinium-225 ([²²⁵Ac]Ac) has been shown to be suitable for antibody-based targeting but lacks chelate stability and conjugation reproducibility. CD276 (B7-H3) has been shown to be broadly overexpressed in various solid tumors and thus presents as a suitable therapeutic target. We developed and evaluated a well-defined [²²⁵Ac]Ac-Macropa-PEG₂-Enoblituzumab radioimmunoconjugate prepared using thiol-maleimide-based PEG₂-Macropa conjugation strategy.</p><p><strong>Materials and methods: </strong>The Enoblituzumab was activated (thiolated) using Traut's reagent followed by conjugation with activated Macropa-PEG₂ using EDC/NHS chemistry. The Macropa-PEG₂-Enoblituzumab conjugate was characterized by SEC-HPLC and MALDI-TOF MS. Radiolabeling with [²²⁵Ac]Ac- was achieved under mild conditions and the [²²⁵Ac]Ac-Macropa-PEG₂-Enoblituzumab assessed with iTLC and radio-SEC-HPLC. Functional studies involved saturated binding & internalization analyses using CD276-positive DU145-B7-H3 cells and CD276-negative CHO-K1 controls. Biodistribution, dosimetry, and therapeutic effectiveness were assessed using DU145-B7-H3 xenograft-bearing mice model with excess Enoblituzumab blocking and non-target CHO-K1 controls.</p><p><strong>Results: </strong>The conjugate revealed reproducible chelator incorporation (CAR = 3.4 ± 0.12), efficient radiolabeling (>95%), and in vitro stability (>90% intact up to 7 days). High-affinity binding (K_D = 0.18 ± 0.05 nM) and time-dependent internalization were observed in DU145-B7-H3 cells, with minimal uptake in CHO-K1 controls. In vivo studies showed gradual tumor accumulation (15.7 ± 1.1%ID/g at 72 h) with sustained retention and favorable tumor-to-background ratios. CHO-K1 xenografts showed minimal uptake, and blocking significantly reduced tumor accumulation, confirming receptor-mediated targeting. Therapy studies demonstrated significant tumor growth inhibition and prolonged survival with good tolerability.</p><p><strong>Conclusions: </strong>[²²⁵Ac]Ac-Macropa-PEG₂-Enoblituzumab shows strong stability, specificity, and therapeutic efficacy, supporting further development as a promising translational candidate for targeted alpha therapy of B7-H3-expressing malignancies.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-16"},"PeriodicalIF":2.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capacity and capability of the RENEB network for large-scale radiological and nuclear emergencies: survey results 2025.","authors":"Jayne Moquet, Stephen Barnard, Joan-Francesc Barquinero, Martin Bucher, Ulrike Kulka, Juan S Martinez, Matthias Port, Andrzej Wojcik, Ursula Oestreicher","doi":"10.1080/09553002.2026.2710751","DOIUrl":"https://doi.org/10.1080/09553002.2026.2710751","url":null,"abstract":"<p><strong>Purpose: </strong>Since 2017, the RENEB network (Running the European Network of Biological and Retrospective Physical Dosimetry) is a group of specialized laboratories that can provide mutual assistance in individual dose estimation by biological and retrospective physical dosimetry for large-scale radiological or nuclear emergencies in Europe and beyond. To ensure the operability of RENEB, Working Group 'Infrastructures', regularly produce a survey to update partners contact details, collect information on laboratories emergency capacity/capabilities and sample transport.</p><p><strong>Methods: </strong>An online survey was developed and distributed to RENEB members and completed in May 2025.</p><p><strong>Results: </strong>Replies were received from scientists working in 29 institutes and provide a clear picture of the RENEB network's capacity and capability.</p><p><strong>Conclusions: </strong>The data collected gives reassurance that RENEB is ready to react to a large-scale radiological event, as well as giving key information about operational aspects which will be essential during an emergency.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-9"},"PeriodicalIF":2.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of a combination of monoclonal antibodies and chemoradiotherapy for the treatment of locally advanced cervical cancer in Chinese patients: a systematic review and meta-analysis.","authors":"Xindi Feng, Liangyu He, Yudong Gao, Yin Qiu, Jiajia Cao, Bowei Ju","doi":"10.1080/09553002.2026.2710755","DOIUrl":"https://doi.org/10.1080/09553002.2026.2710755","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to systematically evaluate the efficacy and safety of combining monoclonal antibodies with chemoradiotherapy for the treatment of locally advanced cervical cancer (LACC) in Chinese patients.</p><p><strong>Materials and methods: </strong>A systematic search was performed in PubMed, Web of Science, Excerpta Medica Database (Embase), China National Knowledge Infrastructure (CNKI), and WanFang for randomized controlled trials, cohort studies, and prospective single-arm studies assessing monoclonal antibodies (anti-EGFR, anti-VEGF, and PD-1 inhibitors) in combination with chemoradiotherapy for LACC, from inception to 5 February 2025. Literature screening, data extraction, and bias assessment were conducted independently by two researchers. Meta-analysis was performed using Stata version 14.0 software.</p><p><strong>Results: </strong>Eighteen studies involving 776 patients were included. The pooled objective response rate was 90% (95% confidence interval [CI]: 0.85-0.95), complete response rate 65% (95% CI: 0.56-0.74), and disease control rate 94% (95% CI: 0.92-0.96). The 1-, 2-, 3-, and 5-year overall survival rates were 98%, 93%, 89%, and 80%, respectively. Common adverse events included gastrointestinal reactions (55%), leukopenia (51%), anemia (59%), and fatigue (20%). The mortality rate was 10%, and recurrence rate was 22% (95% CI: 0.12-0.35).</p><p><strong>Conclusions: </strong>Combining monoclonal antibodies with chemoradiotherapy is effective and safe for LACC, demonstrating favorable treatment outcomes.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-16"},"PeriodicalIF":2.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-maturing, high-yielding M5 mutant lines of cowpea (<i>Vigna unguiculata</i>) derived from gamma irradiation exhibit enhanced seed protein and mineral composition: implications for nutritional biofortification.","authors":"Prosper Deo-Donne Lumorh, Innocent Kwaku Dorvlo, Godwin Amenorpe, Paul Agu Asare, Michael Osei Adu, Emmanuel Afutu, Mishael Amoah Nyarko, Michael Odenkey Quaye, Edward Bariam, Benjamin Kwasi Offei, Patrick Twumasi, Samuel Amiteye","doi":"10.1080/09553002.2026.2708815","DOIUrl":"https://doi.org/10.1080/09553002.2026.2708815","url":null,"abstract":"<p><strong>Purpose: </strong>Cowpea (Vigna unguiculata (L.) Walp.) is the primary grain legume in sub-Saharan Africa, yet protein-energy malnutrition and micronutrient deficiencies persist widely across the region. This study evaluates the proximate and mineral composition of twelve early-maturing, high-yielding M5 mutant lines derived through multi-generational pedigree selection from ⁶⁰Co gamma irradiation (452 Gy) of the Ghanaian cowpea cultivar Hansadua.</p><p><strong>Materials and methods: </strong>Seeds harvested from a randomized complete block design (three replications) at the University of Cape Coast, Ghana, were analyzed for proximate composition (protein, fat, fiber, ash, carbohydrate, moisture) and mineral content (N, Ca, Na, K, Mg, Fe) using AOAC and wet acid digestion methods.</p><p><strong>Results: </strong>All twelve parameters differed significantly (p < .001) among genotypes. Crude protein ranged from 18.96 ± 0.09% to 30.49 ± 0.14%, compared to 20.54 ± 0.09% in the parent; ten of twelve mutant lines exceeded Hansadua. All mutant lines surpassed the parent in calcium (44.47-105.60 mg/100 g) and potassium (745.87-1,112.03 mg/100 g). Protein was strongly correlated with nitrogen (r = 0.99, p < .001) and magnesium (r = 0.60, p < .001) but was independent of iron (r = 0.18, p > .05).</p><p><strong>Conclusion: </strong>Mutant lines HanM4(12)(3), HanM4(52)HY, and HanM4(33)(HY43) show promise for cowpea biofortification breeding efforts aimed at fighting protein-energy malnutrition and mineral deficiencies in West Africa.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-9"},"PeriodicalIF":2.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic 3.5 GHz radiofrequency exposure is associated with behavioral, molecular, and histopathological changes in the rat hippocampus.","authors":"Hava Bektas, Serife Cakir, Ares Alizade, Semih Dogu, Fikret Altindag","doi":"10.1080/09553002.2026.2708930","DOIUrl":"https://doi.org/10.1080/09553002.2026.2708930","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic exposure to mid-band radiofrequency (RF) electromagnetic fields at 3.5 GHz is increasingly relevant to modern wireless environments; however, its effects on hippocampal circuit stability under non-thermal conditions remain unclear. We investigated whether prolonged 3.5-GHz RF exposure is associated with anxiety-like behavior and hippocampal transcript-level changes consistent with excitatory-inhibitory (E/I) imbalance, and whether thymoquinone (TQ) or taurine (TAU) are associated with modulation of these responses.</p><p><strong>Materials and methods: </strong>Adult male Wistar rats (<i>n</i> = 28) were assigned to Sham, RF, RF + TQ (20 mg/kg), or RF + TAU (20 mg/kg) groups (<i>n</i> = 7/group). Animals were exposed to a GSM-like 3.5-GHz RF signal (2 W; 2 h/day; 5 days/week; 10 weeks). Anxiety-like behavior and spatial learning were assessed using the Elevated Plus Maze (EPM) and Morris Water Maze (MWM). Hippocampal gene expression (<i>bdnf, creb1, camk2a, th, tph2, gad1, slc17a7</i>) was quantified by RT-qPCR, and histopathology by H&E staining.</p><p><strong>Results: </strong>Dosimetry indicated whole-body SAR of 0.0383 W/kg and brain gray matter SAR of 0.3411 W/kg. RF exposure was associated with reduced open-arm time in the EPM. Expression of <i>slc17a7</i> increased in the RF group, suggesting a shift toward excitation. Under RF co-exposure conditions, TQ and TAU were associated with changes in <i>slc17a7</i> expression and with increases in <i>bdnf</i>, <i>creb1</i>, and <i>camk2a</i>, along with inhibitory and monoaminergic markers. RF-exposed hippocampi showed neuronal degeneration, less pronounced in antioxidant-treated groups.</p><p><strong>Conclusions: </strong>Chronic non-thermal 3.5-GHz RF exposure is associated with anxiety-like behavior and a hippocampal molecular-structural profile consistent with E/I imbalance and tissue stress. TQ and TAU were associated with context-dependent changes under RF co-exposure conditions; however, due to the absence of antioxidant-only control groups, independent effects cannot be determined. These findings suggest that synaptic homeostasis may represent a potential target of prolonged mid-band RF exposure.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-14"},"PeriodicalIF":2.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Declaration of Adelaide White paper: Guidelines for Author Responsibility in Peer Review.","authors":"Loredana G Marcu, Chris Clement, Anna Friedl, Richard Harbron, Werner Rühm, Magdalena Stoeva, Michael Thorne, Iuliana Toma-Dasu, Jamie Trapp, Andrzej Wojcik, Gayle Woloschak","doi":"10.1080/09553002.2026.2682102","DOIUrl":"https://doi.org/10.1080/09553002.2026.2682102","url":null,"abstract":"","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-2"},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of mitochondrial DNA haplogroup, oxidative DNA damage and inflammatory markers in middle-aged adults.","authors":"Jessica T Smith, Nicole Noren Hooten, Nicolle A Mode, Alan B Zonderman, Ngozi Ezike, Michele K Evans","doi":"10.1080/09553002.2026.2699714","DOIUrl":"10.1080/09553002.2026.2699714","url":null,"abstract":"<p><strong>Purpose: </strong>Previous literature suggests that African American adults have higher levels of systemic oxidative stress than White adults. Mitochondrial DNA (mtDNA) variants can be traced to geographic origins of populations and classified into haplogroups. Emerging evidence indicates that mtDNA haplogroup may affect cellular stress responses such as the response to irradiation or oxidative stress. However, little is known about whether mtDNA haplogroup influences systemic baseline or induced levels of oxidative DNA damage.</p><p><strong>Materials and methods: </strong>We determined mtDNA haplogroup (African American or European) in 104 middle-aged adults living above and below poverty to investigate the association of mtDNA haplogroup and inflammatory markers with baseline and H₂O₂-induced DNA damage in peripheral blood mononuclear cells. DNA damage was measured using a high-throughput CometChip assay. Several inflammatory markers were measured in serum. Linear regression examined if variables were related to DNA damage in interactions or independently.</p><p><strong>Results: </strong>mtDNA haplogroup alone did not influence levels of baseline or H₂O₂-induced DNA damage. However, baseline and H₂O₂-induced DNA damage were associated with poverty, sex, age, and markers of inflammation. Baseline DNA damage was related to IL-6 levels differentially based on poverty status. Baseline DNA damage was inversely associated with levels of IL-8. Men showed overall higher levels of H₂O₂-induced DNA damage. H₂O₂-induced DNA damage was also related to IL-6 levels but differentially based on age. mtDNA haplogroup did affect both baseline and H₂O₂-induced DNA damage through differential effects on two markers of inflammation.</p><p><strong>Conclusion: </strong>These data suggest that mtDNA haplogroup plays an indirect role in the cellular response to endogenous and exogenous oxidative stress. Sex and age may also contribute to levels of inflammation in the DNA damage response. Finally, the social determinant of health poverty status, appears to play a role in interactions with inflammatory markers for baseline DNA damage at mid-life.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-12"},"PeriodicalIF":2.4,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13470647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical, structural and mutational landscapes of base excision repair enzymes and cancer: from atomic resolution to tumor signatures.","authors":"Simone Hall, Cameron Cordero, Mohammad Hashemian, Marcos B Ngo, Sheila S David, Steven A Roberts, Joann B Sweasy, Sylvie Doublié","doi":"10.1080/09553002.2026.2686689","DOIUrl":"10.1080/09553002.2026.2686689","url":null,"abstract":"<p><strong>Purpose: </strong>Base excision repair (BER) is the predominant pathway for repairing non‑bulky oxidized and alkylated DNA base lesions, and its fidelity depends on the coordinated action of lesion‑specific DNA glycosylases and downstream repair enzymes. This review aims to summarize recent structural, biochemical, and genomic insights into three base excision repair enzymes, MUTYH DNA glycosylase, NTHL1 DNA glycosylase, and DNA polymerase β.</p><p><strong>Conclusion: </strong>This review outlines how MUTYH, NTHL1 and DNA polymerase β protect the genome from mutagenesis, highlights major germline variants associated with disease, and synthesizes the current knowledge on the characteristic single base substitution (SBS) mutational signatures that occur when these repair enzymes are dysfunctional.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-18"},"PeriodicalIF":2.4,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}