International journal of radiation biology最新文献

Image selection is critical in the dicentric chromosome assay in cytogenetic biodosimetry. 在细胞遗传学生物剂量测定中，图像选择是双中心染色体测定的关键。

IF 2.4

International journal of radiation biology Pub Date : 2025-10-08 DOI: 10.1080/09553002.2025.2566688

Ayaka Okimoto, Donovan Anderson, Yohei Fujishima, Yui Kadowaki, Hinata Suzuki, Tomisato Miura

{"title":"Image selection is critical in the dicentric chromosome assay in cytogenetic biodosimetry.","authors":"Ayaka Okimoto, Donovan Anderson, Yohei Fujishima, Yui Kadowaki, Hinata Suzuki, Tomisato Miura","doi":"10.1080/09553002.2025.2566688","DOIUrl":"https://doi.org/10.1080/09553002.2025.2566688","url":null,"abstract":"Purpose: The dicentric chromosome assay (DCA), recognized as the gold standard for biological dosimetry in emergency radiation exposure, involves multiple key steps. Among these, metaphase image selection remains ambiguous and particularly challenging for beginners. This study evaluates the impact of metaphase image selection on dicentric (Dic) frequency during initial training.Materials and methods: Peripheral blood (PB) from three healthy donors was irradiated with 2 Gy X-rays and incubated at 37 °C for 2 h for DNA repair. PB samples were then cultured for 48 h with phytohemagglutinin and colcemid. After fixation, metaphase spreads were prepared, Giemsa-stained, and images were captured by specific microscope imaging and image processing software. Three beginners independently selected and analyzed 50 metaphase images each. A trainer with experience in performing radiation emergency related DCA then reviewed and removed unsuitable images. The beginners reanalyzed Dic frequencies, supplementing with additional images as needed to reach 50 metaphases. Dic frequencies were compared before and after image refinement.Results: Dic frequencies were lower in metaphase image pools selected by beginners compared to those refined by the trainer. The novices' selections included numerous over-condensed metaphases, making Dic detection difficult.Conclusion: Blood culture for 48 h permanent colcemid treatment increases the occurrence of over-condensed chromosomes, affecting Dic scoring. This study highlights the importance of proper training in metaphase image selection and structured education on quality assessment, including the use of specific microscope imaging and image processing software to ensure accurate biological dosimetry.","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-7"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 2.4

International journal of radiation biology Pub Date : 2025-10-03 DOI: 10.1080/09553002.2025.2566614

引用次数: 0

Investigation of the effect of yeast NADH dehydrogenase (NDI1) on the radiation-induced bystander response in HCT116 cells with wild-type p53 function. 酵母NADH脱氢酶（NDI1）对具有野生型p53功能的HCT116细胞辐射诱导旁观者反应影响的研究

IF 2.4

International journal of radiation biology Pub Date : 2025-10-03 DOI: 10.1080/09553002.2025.2566684

Megan Li, Colin Seymour, Carmel Mothersill

{"title":"Investigation of the effect of yeast NADH dehydrogenase (NDI1) on the radiation-induced bystander response in HCT116 cells with wild-type p53 function.","authors":"Megan Li, Colin Seymour, Carmel Mothersill","doi":"10.1080/09553002.2025.2566684","DOIUrl":"https://doi.org/10.1080/09553002.2025.2566684","url":null,"abstract":"Purpose: Radiation-induced bystander effects describe the biological effects in unirradiated cells induced by signals from nearby radiation-targeted cells. Although the bystander effect has been well demonstrated in cell cultures, the mechanisms underlying how bystander signaling induces mitochondrial dysfunction and metabolic alterations are not fully understood. Of interest to this study is the impairment of mitochondrial Complex I's function in non-targeted mammalian cells.Methods: NADH dehydrogenase from Saccharomyces cerevisiae (yeast) (NDI1) has been shown to restore functionality to mitochondria where complex I is inactive. In this study, NDI1 or an empty vector control was transfected into bystander human colon carcinoma cells with wild-type p53 function (HCT116 p53+/+) to investigate the effect heterologous complex has on cellular response following direct and indirect Cs-137 gamma irradiation.Results: HCT116 p53+/+ were successfully transfected with either the empty vector control or NDI1 vector. NDI1 expressing cells showed no significant decrease in clonogenic survival after exposure to irradiated cell conditioned medium compared to controls.Discussion: Our study suggests the alternative respiratory enzyme is able to prevent the reduction in colony formation in bystander cells. Yeast NDI1 expression may present a method to study the mechanisms by which bystander signals modulate Complex I activity. However, we cautiously note the results are preliminary in nature, and this work is an exploratory step toward mechanistic validation rather than conclusive evidence. There is a need for further validation to confirm mitochondrial localization and function of NDI1.","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-8"},"PeriodicalIF":2.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upregulation of miR-206 attenuates breast cancer cell survival and increases their radiosensitivity. miR-206的上调会降低乳腺癌细胞的存活率并增加其放射敏感性。

IF 2.4

International journal of radiation biology Pub Date : 2025-10-01 DOI: 10.1080/09553002.2025.2540359

Parvaneh Seiri, Parichehr Mehrafshar, Mitra Nourbakhsh, Zahra Hesari, Zohreh Abdolvahabi, Mohammad Soukhtanloo, Pegah Golpour, Zeynab Yousefi, Sahar Yarahmadi, Samira Ezzati Mobaser, Meysam Abolmaali, Zahra Abbasian, Hannaneh Zarrinnahad, Nazanin Hosseinkhan, Seied Rabi Mahdavi

{"title":"Upregulation of miR-206 attenuates breast cancer cell survival and increases their radiosensitivity.","authors":"Parvaneh Seiri, Parichehr Mehrafshar, Mitra Nourbakhsh, Zahra Hesari, Zohreh Abdolvahabi, Mohammad Soukhtanloo, Pegah Golpour, Zeynab Yousefi, Sahar Yarahmadi, Samira Ezzati Mobaser, Meysam Abolmaali, Zahra Abbasian, Hannaneh Zarrinnahad, Nazanin Hosseinkhan, Seied Rabi Mahdavi","doi":"10.1080/09553002.2025.2540359","DOIUrl":"https://doi.org/10.1080/09553002.2025.2540359","url":null,"abstract":"Background: MicroRNAs (miRNAs) are a group of small non-coding RNAs that substantially participate in regulating gene expression. Their participation in cancer development encompasses various critical pathways, spanning from cell transformation to the progression of tumor cells, metastasis, and even resistance to treatment. This study aimed to assess the impact of miR-206 on radiosensitivity in breast cancer (BC) cells, SIRT1 activity, and p53 acetylation.Method: miR-206 mimic or inhibitor was transfected into BC cell lines and exposed to X-ray radiation. MTT and colony-forming assays were used to estimate cell viability, and apoptosis was inspected using flow cytometry. SIRT1 enzymatic activity was assessed by a fluorescence method. The protein levels of p53 and its acetylation status were evaluated using western blotting. miR-206 levels were assessed in the breast tumor, marginal, and normal control tissue.Results: The expression of miR-206 was significantly reduced in BC cell lines and tumor tissue compared to normal tissue. miR-206 reduced cell viability and induced apoptosis, and could enhance the suppressive effects of irradiation on cell viability, colony formation, and its ability to induce apoptosis. miR-206 effectively suppressed SIRT1 activity in BC cells. Moreover, miR-206 significantly increased the levels of p53 and its acetylated form.Conclusion: The upregulation of miR-206 enhanced the efficacy of radiotherapy by promoting apoptosis and reducing cell survival. It also resulted in elevated levels of p53 and its acetylation. Therefore, miR-206 may be considered a promising candidate for radiosensitizing BC cells.","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-12"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of boron neutron capture therapy on biological behavior of nasopharyngeal carcinoma. 硼中子俘获治疗对鼻咽癌生物学行为的影响。

IF 2.4

International journal of radiation biology Pub Date : 2025-09-30 DOI: 10.1080/09553002.2025.2566690

Yun Hou, Jiangwei Kong, Yujun Zhong, Feifei Li, Youhu Wang, Fangfang Wang, Xudong Wei

{"title":"Effect of boron neutron capture therapy on biological behavior of nasopharyngeal carcinoma.","authors":"Yun Hou, Jiangwei Kong, Yujun Zhong, Feifei Li, Youhu Wang, Fangfang Wang, Xudong Wei","doi":"10.1080/09553002.2025.2566690","DOIUrl":"https://doi.org/10.1080/09553002.2025.2566690","url":null,"abstract":"Background: Boron Neutron Capture Therapy (BNCT) shows clinical promise for cancer treatment, particularly in addressing radiotherapy resistance, the primary cause of local recurrence in nasopharyngeal carcinoma (NPC). Research on BNCT for both conventional and radiotherapy-resistant NPC remains limited.Objectives: This study evaluates BNCT's efficacy against NPC using parental 5-8 F and radiotherapy-resistant 5-8 F-IR cell lines, comparing its effects to γ-rays and thermal (BPA), and 10B uptake was quantified via ICP-MS. Cytotoxicity (CCK-8), migration (Transwell), invasion, and clonogenic assays validated radioresistance in 5-8 F-IR. BNCT's impact on proliferation, apoptosis, and cell cycle (G2/M arrest) was assessed.Results: BPA showed no toxicity, with 10B uptake reaching 1 × 109 atoms/cell after 2 h. BNCT inhibited proliferation and induced apoptosis in 5-8 F cells dose-dependently. For 5-8 F-IR (40 μg/mL 10B), BNCT suppressed proliferation, migration, and invasion more effectively than γ-rays or neutrons, inducing significant G2/M arrest.Conclusions and significance: BNCT enhances radiosensitivity in NPC, particularly for resistant cases, outperforming conventional radiotherapy. BPA's targeted delivery and BNCT's cytotoxic effects support its potential as a salvage therapy for recurrent NPC.","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-13"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological changes induced by gamma radiation on the cuticle and antennal sensilla of Acanthoscelides obtectus adults. 伽玛辐射对棘皮虫成虫表皮和触角感受器的形态学影响。

IF 2.4

International journal of radiation biology Pub Date : 2025-09-30 DOI: 10.1080/09553002.2025.2567048

Ali F Hamza, Nagwan F Zahran, Hassan A Gad

{"title":"Morphological changes induced by gamma radiation on the cuticle and antennal sensilla of Acanthoscelides obtectus adults.","authors":"Ali F Hamza, Nagwan F Zahran, Hassan A Gad","doi":"10.1080/09553002.2025.2567048","DOIUrl":"https://doi.org/10.1080/09553002.2025.2567048","url":null,"abstract":"Purpose: Acanthoscelides obtectus is considered as one of the most dangerous insect pest of stored legume crops. Scanning electron microscopy (SEM) was used to studying morphological changes induced by gamma radiation on the cuticle and antennal sensilla of A. obtectus adults.Materials and methods: Antennal structure of the normal and irradiated A. obtectus adults as 1-2 days old pupae at four doses (50, 100, 150 and 200 Gy) was examined using SEM to study the changes in the antennal segments and associated sensilla.Results: The antenna of A. obtectus is covered with a high density of sensilla. Five sensillum types have been observed in both sexes: Böhm bristles, sensilla chaetica, sensilla trichodea, sensilla basiconica and sensilla coeloconica. Due to the gamma radiation doses (50, 100, 150, and 200 Gy), morphological changes were observed in the antennal segments and their associated sensilla. These changes included shrinkage, sensilla curvature into different directions, irregular shape, swelling in certain areas, and sensilla gathered into dense collections. At 150 and 200 Gy doses, these alterations were clearly visible, while at case of irradiated pupae with 50 Gy, there were only minor abnormalities. Also, morphological changes caused in body cuticle were splitting between the elytra and between the thorax and elytra. Furthermore, a decrease in sensilla density was observed in certain areas of the elytra.Conclusions: All these malformations may lead A. obtectus to not reaching the host, impeding their ability to infest the common bean seeds, and this is the primary goal of this investigation.","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors governing individual response to ionizing radiation and risk of diseases of the circulatory system: human epidemiological studies. 控制个体对电离辐射反应和循环系统疾病风险的因素：人类流行病学研究。

IF 2.4

International journal of radiation biology Pub Date : 2025-09-23 DOI: 10.1080/09553002.2025.2561808

Preetha Rajaraman, Andreas Klaus Breitbarth, Mai Utada, Syed Asrafuzzaman, Amy Berrington de Gonzalez, Nobuyuki Hamada, Mark P Little

{"title":"Factors governing individual response to ionizing radiation and risk of diseases of the circulatory system: human epidemiological studies.","authors":"Preetha Rajaraman, Andreas Klaus Breitbarth, Mai Utada, Syed Asrafuzzaman, Amy Berrington de Gonzalez, Nobuyuki Hamada, Mark P Little","doi":"10.1080/09553002.2025.2561808","DOIUrl":"https://doi.org/10.1080/09553002.2025.2561808","url":null,"abstract":"Purpose: Growing evidence from the Japanese atomic bomb survivors, and occupationally and medically exposed groups indicates that ionizing radiation could increase the risk of various diseases of the circulatory system (DCS), even at low levels of exposure. As radiation protection systems increasingly consider the possibility of individualized radiation protection, better understanding is needed of the factors that may impact radiation-related risk, whether intrinsic (such as age, sex or genetics), or extrinsic (such as smoking). Here, we comprehensively review potential effect modification of radiation exposure and the risk of DCS in medical, occupational and environmental settings.Conclusion: Several studies indicate potential effect modification, usually detrimental, with use of anthracycline in medical settings. There was some indication that younger age at exposure increased risk for various DCS outcomes, but this was less consistent across studies and settings. Interpretation of the data is complicated by considerations of statistical power, differences in specific disease outcomes, and narrow ranges of exposure and/or potential modifiers within studies. Future studies with well-defined exposure over a wide range of ages, along with biological samples, are required to better inform the nature of these interactions.","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-13"},"PeriodicalIF":2.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary analysis of the integrated EPR signals of fingernails to validate the dosimetry method based on peak-to-peak amplitudes. 初步分析指甲EPR信号，验证基于峰间振幅的剂量测定方法。

IF 2.4

International journal of radiation biology Pub Date : 2025-09-23 DOI: 10.1080/09553002.2025.2561815

Hiroshi Yasuda, Samayeh Azariasl, François Trompier

{"title":"Preliminary analysis of the integrated EPR signals of fingernails to validate the dosimetry method based on peak-to-peak amplitudes.","authors":"Hiroshi Yasuda, Samayeh Azariasl, François Trompier","doi":"10.1080/09553002.2025.2561815","DOIUrl":"https://doi.org/10.1080/09553002.2025.2561815","url":null,"abstract":"Introduction: Although the dosimetry technique using fingernails coupled with electron paramagnetic/spin resonance (EPR/ESR) spectroscopy (hereafter called 'fingernail EPR dosimetry') has practical advantages, more efforts to improve its accuracy and reliability are required for application to dose assessment in radiological accidents.Purpose: In fingernail EPR dosimetry, an absorbed dose is determined from the peak-to-peak amplitude of the main peak of the EPR signal spectrum, whereas the measured spectrum is the first derivative of the microwave absorption band. This study aimed to confirm the validity of this approach based on peak deconvolution analysis of the integrated EPR spectra of irradiated fingernails.Methods: Fingernail samples collected from two donors (an 11-year-old child and a 62-year-old adult) were irradiated with X-rays (160 kV, 6.3 mA) at different doses (0, 5, 10, and 20 Gy) and EPR signals were measured using an X-band EPR spectrometer. The measured EPR spectra were integrated and deconvoluted into major components.Results: The integrated EPR spectra were successfully deconvoluted into three Gaussian peaks with central magnetic field values of 327.42, 327.55, and 327.63 mT. All the peaks of the child fingernails showed linear dose responses. In contrast, the three peaks of the adult fingernails presented notably different dose responses; it was implied that the reduction in radiation sensitivity of the peak-to-peak amplitude was not attributable to the major peak.Conclusions: The findings presented in this study underscore the importance of examining the behaviors of the overlapping peaks in fingernail EPR spectra on an individual basis to achieve more reliable fingernail EPR dosimetry.","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-8"},"PeriodicalIF":2.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heavy ion radiation induces pyroptosis in skin keratinocytes through a mitogen-activated protein kinase signaling pathway. 重离子辐射通过丝裂原激活的蛋白激酶信号通路诱导皮肤角质形成细胞焦亡。

IF 2.4

International journal of radiation biology Pub Date : 2025-09-23 DOI: 10.1080/09553002.2025.2561813

Zhiqiang Zhang, Haoxiang Wang, Yumeng Huang, Liming Zhu, Xuanyu Wang, Yan Du, Guangming Zhou, Ye Zhao

{"title":"Heavy ion radiation induces pyroptosis in skin keratinocytes through a mitogen-activated protein kinase signaling pathway.","authors":"Zhiqiang Zhang, Haoxiang Wang, Yumeng Huang, Liming Zhu, Xuanyu Wang, Yan Du, Guangming Zhou, Ye Zhao","doi":"10.1080/09553002.2025.2561813","DOIUrl":"https://doi.org/10.1080/09553002.2025.2561813","url":null,"abstract":"Purpose: To elucidate the mechanisms underlying pyroptosis in skin due to heavy ion radiation.Materials and methods: Human keratinocytes (HaCaT cells) were irradiated with different doses of X-rays and 12C ions. Clonogenic survival, CCK-8 cell proliferation, and micronucleus assays were performed to assess the radiosensitivity of HaCaT cells. The pyroptosis-related, inflammation-related, and MAPK/NF-κB signaling pathway proteins were detected by Western-blotting.Results: 12C ion radiation caused more severe damage to HaCaT cells than X-rays. The former induced pyroptosis in the HaCaT cells in a dose-dependent manner. Heavy ion-induced pyroptosis was activated by the Caspase-4/Caspase-5/Gasdermin D (GSDMD) pathway, which was regulated by the MAPK/NF-κB signaling pathway.Conclusions: 12C ion irradiation induced pyroptosis in human keratinocytes by a non-classical pathway via the activation of MAPK/NF-κB signaling pathway. The findings may be used to guide further research on targeted interventions to reduce skin damage and optimize treatment strategies in the future.","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-9"},"PeriodicalIF":2.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and cosmetic outcomes of high-dose-rate brachytherapy in the treatment of nasal carcinomas: a retrospective analysis. 高剂量率近距离放射治疗鼻癌的疗效和美容效果：回顾性分析。

IF 2.4

International journal of radiation biology Pub Date : 2025-09-23 DOI: 10.1080/09553002.2025.2561807

Leila Ettalhaoui, Arnaud Beddok, Felix Felici, Nathaniel Assouly, Esteban Brenet, Alexandre Roque, Manuelle Viguier, Stéphane Vignot, Philippe Guilbert, Antonio Da Silva Ribeiro Mota

{"title":"Efficacy and cosmetic outcomes of high-dose-rate brachytherapy in the treatment of nasal carcinomas: a retrospective analysis.","authors":"Leila Ettalhaoui, Arnaud Beddok, Felix Felici, Nathaniel Assouly, Esteban Brenet, Alexandre Roque, Manuelle Viguier, Stéphane Vignot, Philippe Guilbert, Antonio Da Silva Ribeiro Mota","doi":"10.1080/09553002.2025.2561807","DOIUrl":"https://doi.org/10.1080/09553002.2025.2561807","url":null,"abstract":"Background: Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the most common non-melanoma skin cancers, frequently affecting the facial region. High-Dose Rate (HDR) interstitial brachytherapy (iBT) offers a promising alternative to surgery, particularly in cosmetically sensitive areas like the nasal region. This study evaluates the clinical efficacy and esthetic outcomes of HDR iBT in the treatment of nasal BCC and cSCC.Methods: This retrospective analysis included 10 patients with histologically confirmed primary nasal BCC or cSCC treated with HDR iBT between May 2021 and February 2023. Patients received HDR iBT as either a definitive treatment or post-surgery, depending on clinical indications. The treatment involved image-guided placement of interstitial catheters, with individualized dosimetric planning following GEC-ESTRO and ASTRO guidelines. Prescribed doses ranged from 40 to 45 Gy, delivered in 9-10 fractions.Results: The cohort consisted of 80% male patients, with a median age of 69 years (IQR:49-83), and an equal distribution of BCC and cSCC. After a median follow-up of 23.5 months (IQR:19.5-31), all patients were alive, with a 90% complete response rate. Two patients experienced locoregional recurrences, successfully managed with salvage therapy. Acute toxicities included dermatitis (100%, with 60% grade 3) and pain (50%). Late toxicities were minimal, limited to grade 1 fibrosis (30%) and edema (20%). Esthetic outcomes, assessed via the Global Esthetic Improvement Scale, were excellent in most cases.Conclusion: HDR iBT demonstrates high efficacy with favorable cosmetic outcomes, offering a viable, minimally invasive alternative to surgery for nasal BCC and cSCC.","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-7"},"PeriodicalIF":2.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0