International journal of radiation biology最新文献

{"title":"Radiofrequency radiation and Alzheimer's disease: harmful and therapeutic implications.","authors":"Hava Bektas, Suleyman Dasdag","doi":"10.1080/09553002.2025.2481854","DOIUrl":"https://doi.org/10.1080/09553002.2025.2481854","url":null,"abstract":"<p><strong>Purpose: </strong>Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline. The relationship between AD and radiofrequency (RF) radiation emitted by wireless devices remains under investigation. The aim of this review is to comprehensively explore the effects of RF radiation on AD by evaluating existing literature. This review used Web of Science, Scopus, and PubMed to find relevant studies on AD and RF radiation. This review evaluates a total of 81 studies, including animal models, human studies, and in vitro experiments, with results summarized in tables for clarity.</p><p><strong>Conclusion: </strong>Some studies suggest RF aggravates AD by increasing oxidative stress, impairing blood-brain barrier integrity, and promoting amyloid-beta deposition. Conversely, other studies indicate RF may have protective benefits, such as enhancing brain mitochondrial functions and reducing amyloid-beta levels. Understanding the RF-AD relationship, including parameters like frequency and exposure time, is crucial for therapeutic strategies. The studies reviewed highlight RF radiation's dual effects on AD, underscoring the need for a detailed approach. Further studies are required to clarify these effects and inform preventive and therapeutic measures.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric impacts on height development after radiotherapy for intracranial non-germinomatous germ cell tumors.","authors":"Guanhua Deng, Juan Li, Zhaoming Zhou, Changguo Shan, Jing He, Mingyao Lai, Ping Zhang, Junjie Zhen, Shaoqun Li, Weiping Hong, Xiaolei Hu, Jie Ding, Linbo Cai, Cheng Zhou, Lei Wen","doi":"10.1080/09553002.2025.2473980","DOIUrl":"https://doi.org/10.1080/09553002.2025.2473980","url":null,"abstract":"<p><strong>Objectives: </strong>Intracranial non-germinomatous germ cell tumors (NGGCTs) are rare pediatric central nervous system (CNS) tumors. Growth impairment induced by radiation treatment was rarely evaluated. We aimed to evaluate the impacts of radiotherapy on height development as well as the dosimetric constraints, providing potential insights for hormonal replacement treatment.</p><p><strong>Methods: </strong>A total of 128 pediatric patients diagnosed with NGGCTs were retrospectively studied. Sex, age at irradiation, physical doses and biologically effective dose (BED), height and endocrine status were obtained for analysis. The cumulative change in height was assessed using age-matched normalized height (ANH). Cumulative physical doses and BEDs for the whole brain and pituitary were derived via dose-volume histograms (DVHs) and BED-volume histograms (BEDVHs).</p><p><strong>Results: </strong>For pediatric patients ≤ 11.5 years, linear correlations between ANH and cumulative physical doses as well as BEDs to the whole brain and pituitary were identified. More specifically, dosimetric constraints to the pituitary were 36 Gy for physical dose (AUC = 0.70 [95% CI, 0.54-0.86], <i>p</i> < .05) and 63 Gy₂ BED (AUC = 0.69 [95% CI, 0.53-0.86], <i>p</i> < .05). Impaired hormone secretion with respect to growth hormone (GH) and thyroid-stimulating hormone (TSH) was observed following cranial irradiation (both <i>p</i> < .001), particularly for those with tumors at the suprasellar region (GH: <i>p</i> < .01, TSH: <i>p</i> < .001). Unlikely to patients > 11.5 years, the height development for patients with tumors in the suprasellar region was significantly more affected than those in the other locations (<i>p</i> < .01) among patients ≤11.5 years.</p><p><strong>Conclusions: </strong>Our study revealed the impacts of cumulative doses and tumor locations for radiation-associated growth impairment. Reduced levels of GH and TSH were observed in patients ≤ 11.5 years particularly with tumors in the suprasellar region.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential biomarkers of chronic low-dose radiation exposure for nuclear medicine technologists.","authors":"Irene Mbutu-Austin, Bijan Modarai, Elizabeth Ainsbury, Samantha Y A Terry","doi":"10.1080/09553002.2025.2470225","DOIUrl":"https://doi.org/10.1080/09553002.2025.2470225","url":null,"abstract":"<p><p><b>Purpose:</b> Nuclear medicine is the fastest growing segment in imaging due to an increase in demand for procedures, development of advanced scanners and new radioactive tracers. Technologists are exposed to radiation throughout the workday. Key protection approaches are time, distance, and shielding; these can be difficult to achieve since patients are usually the main source of radiation and close contact is required. Technologists in general nuclear medicine receive annual effective doses of approximately 0.1 mSv. Doses in positron emission tomography (PET) imaging can be close to 6 mSv. Without appropriate radiation protection measures, finger doses from handling PET radiopharmaceuticals can exceed the annual dose limit of 500 mSv. Estimates of health risks from low dose-rate exposures are extrapolated from risk coefficients calculated from Japanese atomic bomb survivors. Effects of chronic exposure are obtained from nuclear workers and radiotherapy patients. This review aims to consolidate existing research in biomarkers of low dose radiation exposure to determine whether they may form a part in occupational health monitoring. <b>Conclusions:</b> The link between chronic low-dose exposure in nuclear medicine technologists and health risks using radiation-related biomarkers as a proxy remains relatively unexplored. Further work is needed to identify and characterize biomarkers in technologists.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of polysaccharide POM extracted from <i>Pleurotus ostreatus</i> in curbing and treating the harmful effects on liver and kidney resulting from radiation exposure.","authors":"Manal G Mahmoud, Mohsen S Asker, Mona A M Ghoneim, Amal I Hassan, Hala F Osman","doi":"10.1080/09553002.2025.2473979","DOIUrl":"10.1080/09553002.2025.2473979","url":null,"abstract":"<p><strong>Purpose: </strong>This research assesses the radioprotective and antioxidant activity of polysaccharide (POM) derived from <i>Pleurotus ostreatus</i> strain on rats suffering from metabolic problems due to irradiation. The crude POM obtained through chemical analysis was found to consist of glucose, galactose, and fructose in 1:1.2:0.1 ratio but was absent of uronic acid, and sulfate. Moreover, it demonstrated radical scavenging activity (45.21-84.21%) at 5 mg/ml concentration.</p><p><strong>Methods: </strong>A total of thirty-two male Sprague-Dawley rats were used and split into four groups: control, radiation (whole body RT with 5 Gy gamma rays), POM treatment (28 days at 100 mg/kg body weight), POM + radiation (n = 8 rats/group). Monitoring of body weight was done and on day 28, cardiac blood samples were collected and tested on liver and kidney function indices. ELISA was used to test for inflammatory factors and liver and kidney sections were stained with hematoyxlin-eosin, and other tests for DNA fragmentation were undertaken.</p><p><strong>Results: </strong>The rats that underwent radiation exhibited reduced body weights, metabolic disruption, and decrease in antioxidant enzyme activities. The histological analysis displayed edema of hepatic cells, inflammatory cell infiltration, and vacuolar degeneration. On the other hand, rats in the POM + Radiation group showed less severe pathological changes. POM treated rats had restored their liver and kidney functions, lower TBARS, higher total protein, and improved antioxidant enzyme activities.</p><p><strong>Conclusion: </strong>POM treatment effectively alleviates liver and kidney damage caused by radiation exposure.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A chromosome 2 locus influences the onset of radiation-induced lung disease in mice.","authors":"Lisa Honeyman, Marie-Eve Bergeron, Cin Thang, Amit Kunwar, Erin E McCurry, Christina K Haston","doi":"10.1080/09553002.2025.2473977","DOIUrl":"https://doi.org/10.1080/09553002.2025.2473977","url":null,"abstract":"<p><strong>Purpose: </strong>The onset of distress from radiation-induced lung disease differs among patients and among inbred strains of mice exposed to thoracic cavity radiotherapy. For the latter specifically, C3H/HeJ mice present distress due to pneumonitis at approximately 10-14 weeks following thoracic irradiation, while C57BL/6J mice show distress due to pneumonitis with pulmonary fibrosis at 22-30 weeks. Mapping studies completed in offspring derived from these inbred strains revealed a chromosome 2 locus to be linked to onset of distress in irradiated mice. Herein, we bred and phenotyped a panel of chromosome 2 subcongenic mice with 64 Mb of C3H/HeJ alleles on a C57BL/6J background, to investigate the contribution of the chromosome 2 locus to radiation-induced lung disease.</p><p><strong>Materials and methods: </strong>Mice received 18 Gy to the thoracic cavity and were monitored for the onset of distress. Lung disease was assessed histologically and with bronchoalveolar lavage.</p><p><strong>Results: </strong>Following whole thorax irradiation, subcongenic mice with C3H/HeJ alleles from 95 to 123 Mb showed significantly earlier onset of respiratory distress (16-22 weeks; <i>p</i> < .02) from pneumonitis and fibrosis compared to C57BL/6J mice. These subcongenic mice did not differ from C57BL/6J mice in pneumonitis (<i>p</i> = .23), mast cell counts (<i>p</i> = .96), or lavage neutrophils (<i>p</i> = .69), evident at distress. <i>In silico</i> analyses reveal 246 protein coding genes mapped within the reduced region, 52 of which differ in pulmonary expression of C3H/HeJ, compared to C57BL/6J, mice after whole thorax irradiation.</p><p><strong>Conclusions: </strong>We have identified a 28 Mb region of chromosome 2 to influence the onset of radiation-induced lung disease in mice.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological effects of high-LET irradiation on the circulatory system.","authors":"Yumi Saigusa, Mark P Little, Omid Azimzadeh, Nobuyuki Hamada","doi":"10.1080/09553002.2025.2470947","DOIUrl":"10.1080/09553002.2025.2470947","url":null,"abstract":"<p><strong>Purpose: </strong>High-linear energy transfer (LET) radiation is generally thought to be more biologically effective in various tissues than low-LET radiation, but whether this also applies to the circulatory system remains unclear. We therefore reviewed biological studies about the effects of high-LET radiation on the circulatory system.</p><p><strong>Conclusions: </strong>We identified 76 relevant papers (24 in vitro, 2 ex vivo, 51 in vivo, one overlapping). In vitro studies used human, bovine, porcine or chick vascular endothelial cells or cardiomyocytes, while ex vivo studies used porcine hearts. In vivo studies used mice, rats, rabbits, dogs or pigs. The types of high-LET radiation used were neutrons, α particles, heavy ions and negative pions. Most studies used a single dose, although some investigated fractionation effects. Twenty-one studies estimated the relative biological effectiveness (RBE) that ranged from 0.1 to 130, depending on radiation quality and endpoint. A meta-analysis of 6 in vitro and 8 in vivo studies (selected based on the feasibility of estimating the RBE and its uncertainty) suggested an RBE of 6.69 (95% confidence intervals (CI): 2.51, 10.88) for in vitro studies and 1.14 (95% CI: 0.91, 1.37) for in vivo studies. The meta-analysis of these 14 studies yielded an RBE of 2.88 (95% CI: 1.52, 4.25). This suggests that high-LET radiation is only slightly more effective than low-LET radiation, although substantial inter-study heterogeneity complicates interpretation. Therapeutic effects have also been reported in disease models. Further research is needed to better understand the effects on the cardiovascular system and to improve radiation protection.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-24"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbeam radiation therapy for lung cancer: a review of experimental setups and biological endpoints in preclinical studies.","authors":"Abbie Reynolds, Laure Marignol","doi":"10.1080/09553002.2025.2473981","DOIUrl":"https://doi.org/10.1080/09553002.2025.2473981","url":null,"abstract":"<p><strong>Background: </strong>Microbeam radiation therapy (MRT) seeks to improve the therapeutic ratio of conventional radiation therapy though the delivery of high doses in micrometre-scale beamlets of synchrotron-generated X-rays.</p><p><strong>Purpose: </strong>To assess the MRT experimental setups and biological endpoints used in preclinical studies investigating its therapeutic potential in lung cancer models.</p><p><strong>Methodology: </strong>PubMed, Embase, Science Direct, and Web of Science were searched using the following keywords, 'microbeam', 'micro beam', 'synchrotron' and 'lung'. The reported physical parameters of the MRT set up and biological endpoints chosen to test efficacy were examined.</p><p><strong>Main findings: </strong>Fourteen studies were assessed. The microbeam widths ranged from 25 µm to 630 µm, and the microbeam spacing ranged from 0 µm to 4000 µm. The peak doses ranged up to 1000 Gy and dose rates ranged from 4 Gy/s to 1.4x10⁴ Gy/s. Fibrosis was the most commonly assessed radiation-induced toxicity.</p><p><strong>Conclusion: </strong>MRT experimental set ups and biological endpoints are heterogeneous. Standardization could strengthen future evidence supporting its use for the management of patients with lung cancer.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive organelles of U251 MG glioblastomas to boron neutron capture therapy.","authors":"Jiaomei Bai, Diyun Shu, Changran Geng, Li Li, Xiaoping Sun, Aleksandr Kichigin, Xiaobin Tang, Yuanhao Liu, Ailian Wang, Xiaohong Zhang","doi":"10.1080/09553002.2025.2473978","DOIUrl":"https://doi.org/10.1080/09553002.2025.2473978","url":null,"abstract":"<p><strong>Purpose: </strong>The micro-distribution of boron compounds within cells influences the effectiveness of boron neutron capture therapy (BNCT) in killing tumor cells. Boron neutron capture therapy-sensitive organelles within the range of α particles and ⁷Li recoil nuclei can enhance killing effects on tumor cells. However, comprehensive studies on the sensitive organelles to BNCT are currently lacking. In the present study, we explored the sensitivity of organelles in U251 MG glioblastomas to BNCT.</p><p><strong>Materials and methods: </strong>Trypan blue exclusion assay, the level of autophagic proteins, cell counting kit-8, and clonogenic formation assay were used to evaluate the sensitivity of the cellular membrane, the endoplasmic reticulum, the mitochondria, and the cell nuclei of U251 MG glioblastomas to BNCT (¹⁰B atoms of L-4-boronophenylalanin capture neutrons).</p><p><strong>Results: </strong>Boron neutron capture therapy induced a trypan blue exclusion rate of 93.33%, no changes in the levels of LC3-II and Beclin-1, a survival rate of 77.78%, and reproductive death of 90.25% in U251 MG glioblastomas. These results indicate a hierarchical sensitivity of U251 MG glioblastoma organelles to BNCT ranked as the cell membrane (the endoplasmic reticulum) < the mitochondria < and the cell nucleus. Reproductive death, the main type of U251 MG glioblastoma death induced by BNCT, is attributed to the shortening of the S phase duration.</p><p><strong>Conclusions: </strong>The comprehensive understanding of sensitive organelles within tumor cells to BNCT lays the foundation for significantly improving the efficacy of BNCT in killing tumor cells.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of low dose rate radiotherapy on pain relief, performance score, and quality of life in patients with knee osteoarthritis; a double-blind sham-controlled randomized clinical trial.","authors":"Danial Fazilat-Panah, Seyed Alireza Javadinia, Ali Shabestani Monfared, Fahimeh Attarian, Mansour Babaei, Behnaz Yousefghahari, Saeed Najafzadeh Sadati, Nahid Ahmadi, Hamid Fallah Tafti","doi":"10.1080/09553002.2025.2473975","DOIUrl":"https://doi.org/10.1080/09553002.2025.2473975","url":null,"abstract":"<p><strong>Introduction: </strong>Knee osteoarthritis (OA) is a prevalent chronic condition characterized by progressive damage to the articular cartilage, resulting in chronic pain, swelling, and reduced range of motion with a range of prevalence of 10-40%. This study aims to investigate the efficacy of low-dose radiation as a local treatment option for knee OA symptoms.</p><p><strong>Methods: </strong>In this prospective study, patients with confirmed OA and older than 65 years were randomly assigned to treatment and control groups. The protocol plan IRCT20160706028815N6 was registered in Iranian registry of clinical trials system. The treatment group received 3 Gy radiation over six fractions, while the control group continued routine treatment without radiation. The pain intensity and functional levels were assessed at pretreatment and each month following completion of therapy for six consecutive months by Visual Analog Scale (VAS) and the Lysholm 100-point Scale, respectively. Analgesic medication usage and performance status (PS) were also assessed.</p><p><strong>Results: </strong>The mean age of the patients was 77 years (range 72-89). All variables including VAS pain score, Lysholm scale, PS and analgesic consumption were improved following radiation from first month to the end of assessments (<i>p</i> value <0.01).</p><p><strong>Conclusion: </strong>Results showed significant pain score improvements and enhanced joint function with no adverse effects. Findings were compared with previous studies, revealing mixed conclusions on low dose radiation therapy (LDRT) efficacy. Mechanistic hypotheses suggest LDRT may modulate inflammatory pathways. The study suggests LDRT at 3 Gy could benefit knee osteoarthritis patients and calls for further research on mechanisms of action in early-stage osteoarthritis.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the interplay of selenoproteins and mir-675 in breast cancer: a focus on radiotherapy effects.","authors":"Sevgin Degirmencioglu, Selim Öğüt, Nurten Bahtiyar, Birsen Aydemir, Didem Karaçetin, Fatma Behice Cinemre, Ebru Hacıosmanoğlu Aldoğan, Mehmet Emin Güneş, Alev Kural, Muhammet Bektaş","doi":"10.1080/09553002.2025.2473962","DOIUrl":"https://doi.org/10.1080/09553002.2025.2473962","url":null,"abstract":"<p><strong>Objectives: </strong>The present study aims to investigate the changes in the expression levels of miR-675 and some selenoproteins (Sel K, Sel W, and Sel P) in patients with breast cancer, before and after radiotherapy.</p><p><strong>Subjects and methods: </strong>This study included 35 breast cancer patients who applied to the Department of Radiation Oncology for radiotherapy and 25 healthy female controls. miR-675 expressions were analyzed by using quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Western blot was conducted to determine Sel K, Sel W, and Sel P expression levels. Biochemical parameters and complete blood count were analyzed by autoanalyzer system and automatic cell counter, respectively.</p><p><strong>Results: </strong>Plasma Sel K protein expression levels were decreased in the after-radiotherapy group compared to the control and before-radiotherapy groups, but plasma miR-675 expression levels were lower in both before and after radiotherapy groups compared to the control group.</p><p><strong>Conclusion: </strong>Our findings showed that miR-675 and Sel K expression levels changed after radiotherapy in breast cancer patients. These changes may have the potential to be biomarkers for the effectiveness of radiotherapy in breast cancer.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}