International journal of radiation biology最新文献

{"title":"Significant interruptions in radiotherapy during curative treatment for prostate cancer are correlated with poorer oncological outcomes.","authors":"Miriam Tomaciello, Antonio Sciurti, Luisa Caprara, Miriam Conte, Viviana Frantellizzi, Giuseppe De Vincentis, Lucy Zaccaro, Giorgia Cunicella, Alberto Fallico, Carlo Guglielmo Cattaneo, Roberto Lisi, Silvia Arcieri, Carlina Veneranda Albanese, Paolo Tini, Beatrice Detti, Vanessa Di Cataldo, Monica Mangoni, Giulio Francolini, Giuseppe Migliara, Lorenzo Livi, Francesca De Felice, Giuseppe Minniti, Giovanni Luca Gravina, Valentina Baccolini, Francesco Marampon","doi":"10.1080/09553002.2025.2470202","DOIUrl":"https://doi.org/10.1080/09553002.2025.2470202","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of radical radiotherapy (RT) relevant interruptions (RRI), single (sRRI) or multiple (mRRI), on Biochemical Failure-Free Survival (BFFS), Metastases-Free Survival (MFS) and Overall Survival (OS) in prostate cancer (PCa) patients.</p><p><strong>Methods: </strong>We conducted a retrospective analysis involving 383 patients diagnosed with prostate cancer (PCa) who received radical RT between March 2013 and April 2021, with doses ranging from 60 to 80 Gy (median dose 76.0 Gy), either alone or in combination with androgen deprivation therapy. The study aimed to evaluate the effects of sRRI and mRRI radiation-related interruptions on BFFS, MFS, and OS using the Kaplan-Meier method. Additionally, we adjusted for relevant prognostic factors using three multivariate Cox regression proportional hazard models.</p><p><strong>Results: </strong>In the univariate analysis, it was observed that patients who experienced unexpected RRIs (50.1%: 35.5% sRRI and 14.6% mRRI), resulting in a median overall treatment time prolongation of five days, exhibited a higher incidence of biochemical failure (BF) and metastases (Met). However, no difference was observed in OS. In the multivariate analysis, it was found that RRIs were significantly associated with increased hazards of BF (sRRI, aHR: 4.61, 95% CI: 2.80-7.60; mRRIs, aHR: 9.92, 95% CI: 5.61-17.54), Met (sRRI, aHR: 4.20, 95% CI: 1.97-8.94; mRRI, aHR: 7.01, 95% CI: 2.94-6.71), and all-cause mortality (mRRI, aHR: 1.89, 95% CI: 1.18-3.03).</p><p><strong>Conclusions: </strong>sRRIs were associated with both lower BFFS and MFS, while mRRIs with both BFFS, MFS and OS.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prohibitin2 knockdown decreases glioma malignant phenotypes and radio-resistance by inhibiting mitophagy.","authors":"Xuefei Xue, Huiling Tan, Xingning Jiang, Jingfan Lu, Ting Sun, Wei Yang","doi":"10.1080/09553002.2025.2470203","DOIUrl":"https://doi.org/10.1080/09553002.2025.2470203","url":null,"abstract":"<p><strong>Purpose: </strong>Prohibitin2 (PHB2), located in inner mitochondrial membrane (IMM), is an important receptor to induce mitophagy. PHB2 was identified as a cancer-promoting factor in most cancers. However, the function of PHB2 in glioma cells remains unclear. This study delved into the impact of PHB2 knockdown on the phenotype, radiosensitivity and mitophagy of glioma cells.</p><p><strong>Methods: </strong>PHB2 expression and its clinical relevance in glioma were investigated by western blot, quantitative reverse transcription polymerase chain reaction (qRT-PCR) and TCGA databases. The malignant phenotypes of glioma cells were analyzed in vitro using cell proliferation, cell cycle, wound healing and transwell assay. The radiosensitivity of glioma cells was detected by colony forming assay. The potential mechanism by which PHB2 regulated mitophagy was investigated by coimmunoprecipitation assay.</p><p><strong>Results: </strong>The expression of PHB2 was significantly upregulated in glioma cells and closely correlated with the malignant degree of glioma. The knockdown of PHB2 inhibited the proliferation, migration and invasion activities of glioma cells. Furthermore, PHB2 knockdown enhanced the radiosensitivity of normoxic and hypoxic glioma cells and suppressed the ionizing radiation-induced mitophagy in glioma cells. Cyanide 3-chlorophenylhydrazone (CCCP), a mitophagy agonist, could reverse the phenotypes and radiosensitivity changes elicited by PHB2 knockdown. Additionally, PHB2 regulated the expression of PGAM5 and PINK1 by directly binding to PARL.</p><p><strong>Conclusions: </strong>Our findings revealed that PHB2 knockdown decreased glioma malignant phenotypes and radio-resistance by inhibiting mitophagy <i>via</i> PARL-PGAM5-PINK1-Parkin pathway. PHB2 is a promising candidate target for the development of new therapeutic strategy to enhance the efficacy of radiotherapy for glioma.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of long-term low-dose 2.45 GHz microwave electromagnetic radiation on vulnerable organs in humans: a retrospective study based on patients receiving microwave diathermies in the Department of Rehabilitation Medicine.","authors":"Zhi Zheng, Lihua Huang, Tao Shang, Yanhong Ma, Yiming Xu","doi":"10.1080/09553002.2025.2467671","DOIUrl":"https://doi.org/10.1080/09553002.2025.2467671","url":null,"abstract":"<p><strong>Purpose: </strong>To retrospectively observe the effects of long-term low-dose 2.45 GHz microwave electromagnetic radiation on human vulnerable organs.</p><p><strong>Methods: </strong>This single-center, retrospective cohort study investigated patients who received long-term (20-100 times of microwave therapy within three months) low-dose (≤20 W) microwave therapy in our department five years ago. Patients were identified and followed up using a rehabilitation treatment management system. Adverse events or diseases that developed after microwave treatment were collected. Based on the number of microwave exposures, patients were divided into two groups: the multiple irradiation group (20-50 sessions) and the ultra-multiple irradiation group (50-100 sessions). The incidence of irreversible damage (ocular lesions, nervous system diseases, reproductive system diseases, cardiovascular system diseases, tumors, or early precancerous lesions) within five years after treatment completion was compared between the two groups.</p><p><strong>Results: </strong>A total of 113 valid cases were analyzed. Sixteen adverse events occurred, including two cases related to tumors, nine cases related to cardiovascular and cerebrovascular diseases, five cases related to metabolic diseases, and one case related to nervous system diseases. One patient had multiple conditions. There was no significant difference in the incidence of adverse events between the multiple irradiation group and the ultra-multiple irradiation group (p = .161, OR = 0.307, 95% CI 0.088-1.025). Logistics regression analysis revealed that the number of microwave treatments, treatment frequency per week, and patient gender was not a significant risk factor for adverse events (p = .100, OR = 0.972, 95% CI 0.938-1.006; p = .896, OR = 1.028, 95% CI 0.679-1.575; p = .960, OR = 1.039, 95% CI 0.212-4.609). Advanced age and obesity might be contributing factors for adverse events (p = .001, OR = 0.923, 95% CI 0.877-0.965; p = .002, OR = 0.064, 95% CI 0.009-0.348).</p><p><strong>Conclusions: </strong>Based on this study, receiving less than 100 sessions of low-dose microwave therapy within three months appears to be safe. Advanced age and obesity might increase the risk of adverse events. Due to the deviation that may be caused by the small sample size of this study, it is necessary to carry out prospective randomized controlled studies with larger samples in the future for further verification.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of gamma irradiation treatments on the germination, moisture, viability and radicle length of <i>Quercus frainetto</i> acorns.","authors":"Servet Caliskan, Vedat Aslan, Mesut Tandoğan, Mehmet Özdemir, Safa Balekoglu","doi":"10.1080/09553002.2025.2470208","DOIUrl":"https://doi.org/10.1080/09553002.2025.2470208","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of this study was to ascertain the impact of varying dosages of gamma irradiation on the germination and development of <i>Quercus frainetto</i> acorns.</p><p><strong>Materials and methods: </strong>The acorns were subjected to gamma radiation from a cobalt-60 source at doses of 25, 50, 100, and 200 gray. The germination percentage, mean germination time, and radicle length of the acorns were quantified. Images were used to evaluate the radicle length. Correlation was employed to investigate the relationships between gamma radiation treatments and moisture content, tetrazolium staining, germination percentage, mean germination time, and radicle length.</p><p><strong>Results: </strong>The impact of gamma-ray radiation on acorns was found to significantly affect moisture content, viability, germination percentage, mean germination time, and radicle length. The germination percentage indicated a decline, particularly at 100 Gy. The acorn lots subjected to 25 grays had the highest germination percentage (92%). The germination percentage in the acorn lots treated with 200 grays decreased by approximately half (44%) in comparison to the control (86%), while the radicle length decreased from 14.8 cm to approximately one-tenth (1.4 cm).</p><p><strong>Conclusions: </strong>The findings demonstrated that the germination percentage and radicle length declined with elevated gamma radiation intensity. While low doses of gamma (25 grays) radiation may facilitate germination, higher doses can exert detrimental effects, including the suppression or complete inhibition of germination. The application of gamma treatment has been demonstrated to be an effective method of inhibiting radicle length elongation, a process that is crucial for the storage and postharvest seeding of acorns.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Down-regulation of PCK2 enhanced the radioresistance phenotype of nasopharyngeal carcinoma.","authors":"Yijun He, Li Yan, Ruiqi Zhang, Rui Yang, Zhaolu Kong, Xiaosheng Wang","doi":"10.1080/09553002.2025.2470226","DOIUrl":"https://doi.org/10.1080/09553002.2025.2470226","url":null,"abstract":"<p><strong>Purpose: </strong>Radiotherapy is the main treatment for non-distant metastatic nasopharyngeal carcinoma (NPC). However, about 15% of NPC patients still experience local tumor recurrence after radiotherapy. The mechanisms underlying the radioresistance of NPC have not been fully understood. This study explored the role of phosphoenolpyruvate carboxykinase2 (PCK2) in NPC radiosensitivity.</p><p><strong>Methods: </strong>Two NPC cell lines, SUNE-1 and 5-8 F, were enrolled in this research, and their radioresistant counterparts, SUNE-1R and 5-8FR were obtained by long-term exposure to γ-ray (2 Gy*30 times). Cells response to ionizing radiation (IR) was determined by colony formation assay (C.F.A). Immunofluorescence, microsphere formation assay and ferroptosis test were adopted to compare the difference of DNA damage repair, stemness and cell death between sensitive and resistant NPC cells. The biological functions of PCK2 were investigated by knocking down the endogenous PCK2 in vitro and in vivo. In addition, the tumor morphology and related markers were observed by HE staining and immunohistochemistry assay, respectively.</p><p><strong>Results: </strong>Intracellular PCK2 is transiently upregulated after a single irradiation in both SUNE-1 and 5-8 F cells. However, PCK2 was significantly reduced in radiation-tolerant cells that survived from multiple irradiations. Further work showed that PCK2 down-regulation prevented SUNE-1R and 5-8FR cells from IR-induced ferroptosis, accompanied by increased cell ability of DNA damaged repair and enhanced phenotypes of tumor stem cells.</p><p><strong>Conclusions: </strong>Our findings indicate that low expression of PCK2 is an important phenotypic feature of radioresistant NPC cells. It could be a result of PCK2 involved in regulating radiation-induced ferroptosis. Regulating the expression of PCK2 may provide new strategies for improving NPC radiation sensitivity.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of radiobiological effects induced by radiolabeled antibodies in human cancer cells and fungal cells.","authors":"Jonathan Bonet Ramírez, Kevin J H Allen, Mackenzie E Malo, Connor Frank, Ekaterina Dadachova","doi":"10.1080/09553002.2025.2467691","DOIUrl":"https://doi.org/10.1080/09553002.2025.2467691","url":null,"abstract":"<p><strong>Purpose: </strong>Acute myeloid leukemia (AML) is a deadly form of leukemia, and its treatment often leaves patients immunocompromised, making them vulnerable to fungal infections. Radioimmunotherapy (RIT) is explored for both AML and fungal infections. This study compares the radiobiological effects of alpha emitter Actinium-225 (²²⁵Ac) and beta emitter Lutetium-177 (¹⁷⁷Lu)-labeled antibodies on AML and <i>Cryptococcus neoformans</i> cells.</p><p><strong>Materials and methods: </strong>AML OCI-AML3 and C. neoformans Cap-67 cells were treated with anti-(1-3)-beta-glucan antibody 400-2 and anti-CD33 antibody HuM-195, conjugated to DOTA and radiolabeled with ²²⁵Ac or ¹⁷⁷Lu. Clonogenic survival, γH2A/X staining, and micronuclei assays were conducted. Antibody internalization was assessed by flow cytometry.</p><p><strong>Results: </strong>Both ²²⁵Ac- and ¹⁷⁷Lu-enabled RIT resulted in decreased clonogenic survival in Cap-67 and OCI-AML3 cells, with Cap-67 recovering more rapidly. DNA double-strand breaks and micronuclei formation revealed DNA damage, with fewer micronuclei in OCI-AML3 cells due to radiation destruction. HuM-195 antibody internalized into OCI-AML3 cells, whereas 400-2 did not internalize into Cap-67 cells.</p><p><strong>Conclusions: </strong>While both cell lines showed similar responses to ²²⁵Ac- and ¹⁷⁷Lu-enabled RIT, variations were observed based on cellular structure, doubling times and DNA repair mechanisms. This study offers insights for future in vivo research on fungal infections in cancer setting.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomography-based pulmonary vasculature analysis of decreased lung perfusion after thoracic radiotherapy in patients with lung cancer.","authors":"Yu-Sen Huang, Jenny Ling-Yu Chen, Wei-Chun Ko, Yee-Fan Lee, Yeun-Chung Chang","doi":"10.1080/09553002.2024.2435316","DOIUrl":"10.1080/09553002.2024.2435316","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to quantitatively assess changes in lung perfusion after thoracic radiotherapy in lung cancer patients.</p><p><strong>Materials and methods: </strong>Patients underwent chest computed tomography (CT) for pulmonary vasculature analysis before radiotherapy and at 3 and 12 months after radiotherapy. The correlation between the percentage decrease in lung perfusion after radiotherapy and the delivered radiotherapy dose was analyzed.</p><p><strong>Results: </strong>The ipsilateral lung, where the primary tumor was located, received a significantly higher dose than the contralateral lung (mean dose: 22.9 Gy vs. 6.8 Gy). At 3 months, significant reductions in lung perfusion parameters were observed in the ipsilateral lung (total blood volume (TBV): 13.8%, blood volume in vessels with cross-sectional areas of ≤10 mm²: 12.6%, blood volume in vessels with cross-sectional areas of ≤5 mm²: 11.7%, subpleural vessel count: 21.1%, subpleural vessel area: 16.9%, and subpleural vessel density: 12.3%). Significant negative correlations between perfusion parameters and the radiation dose delivered to the ipsilateral lung were observed. For every 1-Gy increase in the mean dose for the ipsilateral lung, TBV decreased by 0.852% (<i>p</i> = .044), and for every 1% increase in the percentage of lung volume that received more than 20 Gy, TBV decreased by 0.402% (<i>p</i> = .048). The 3-year overall survival of the patients was 75%. No significant association between baseline perfusion parameters and survival was observed.</p><p><strong>Conclusions: </strong>Thoracic radiotherapy significantly reduced pulmonary perfusion, especially in the ipsilateral lung. The reduction in perfusion correlated with the radiation dose. These findings underscore the impact of radiation-induced damage on perfusion.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"35-43"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of immunohistochemical of the effects of flattened and unflattened radiotherapy beams in nude mice breast cancer xenografts.","authors":"Serhat Aras, Seyma Ozkanli, Engin Sumer, Tugba Kul Koprulu, Mustafa Efendioglu","doi":"10.1080/09553002.2024.2445582","DOIUrl":"10.1080/09553002.2024.2445582","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to investigate the radiobiological effects underlying the inhibition of breast cancer (BCa) following radiotherapy in nude mice models, and to evaluate the impact of changes in immunohistochemical parameters induced by FF and FFF beams.</p><p><strong>Materials and methods: </strong>The study included thirty-six adult nude mouse models, which were randomly assigned to five groups: control (G1), breast cancer (BCa) (G2), FF-400 MU/min (G3), FFF-1100 MU/min (G4), and FFF-1800 MU/min (G5). The control group received neither radiation nor treatment, while the BCa group had a cancer model without radiation. The BCa models were subjected to a single dose of 20 Gy of radiotherapy at varying dose rates. Twenty days after the implantation of the MCF-7 cancer cell line, the nude mice were irradiated and sacrificed 48 h later for ER, PR, HER-2, Ki-67, CD-133, Caspase-3, APAF-1, NOS-2 and NOS-3 IHC analysis.</p><p><strong>Results: </strong>A statistically significant decrease in IHC staining values for ER, Ki-67 and NOS-2 was observed in the FF-400 MU/min, FFF-1100 MU/min and FFF-1800 MU/min groups due to radiotherapy compared to the BCa group. The FFF beams demonstrated superior efficacy in the treatment of BCa. The significant differences in Caspase-3 and APAF-1 levels were found between BCa and control groups, while CD-133, NOS-3, HER-2, and PR staining showed no differences between groups.</p><p><strong>Conclusions: </strong>It was concluded that FFF beam was more effective than FF beam for BCa, especially on ER, Ki-67 and NOS-2 IHC parameters.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"264-273"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using ultrasound sequential images processing to predict radiotherapy-induced sternocleidomastoid muscle fibrosis.","authors":"Asma Khodadadi, Manijhe Mokhtari-Dizaji, Reza Ghalehtaki, Niloofar Ayoobi Yazdi","doi":"10.1080/09553002.2025.2453995","DOIUrl":"10.1080/09553002.2025.2453995","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to evaluate the thickness and biomechanical parameters of the sternocleidomastoid muscle (SCM) before, during, and after radiotherapy using ultrasound elastography to predict radiotherapy-induced muscle fibrosis.</p><p><strong>Materials and methods: </strong>The mean daily absorbed doses of 20 SCMs were determined. To find out the Young and shear modulus, shear wave elastography (SWE) and the B-mode sequential images processing method were implemented. In the B-mode sequential images processing method, by administering dynamic stress, the Young and shear modulus were estimated utilizing the maximum gradient and the block-matching algorithms, respectively. The imaging was done before, during the third and sixth weeks of treatment, and 3 months after radiotherapy.</p><p><strong>Results: </strong>There was a statistically significant increase in the maximum thickness during the sixth week compared to before radiotherapy (<i>p</i> = .043). However, this parameter did not change significantly 3 months later (<i>p</i> = .095). The Young modulus (<i>p</i> = .611) derived from SWE did not differ significantly throughout any of the weeks of radiotherapy. But Young and shear modulus increased significantly in the B-mode sequential images processing method before and during the third and sixth weeks of treatment (<i>p</i> = .001). The outcomes observed 3 months after radiotherapy revealed a statistically significant increase in both Young modulus (<i>p</i> = .029) and shear modulus (<i>p</i> = .004) compared to pre-radiotherapy.</p><p><strong>Conclusion: </strong>The Young modulus and shear modulus are introduced as biological markers used to detect the onset of the fibrosis process during the initial radiotherapy fractions.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"411-421"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"γ-Radiations induced phytoconstituents variability in the grains of cultivated buckwheat species of Himalayan region.","authors":"Nidhi Joshi, Kuldip Chandra Verma, Sanjay Kumar Verma, Pawanesh Tamta","doi":"10.1080/09553002.2024.2430246","DOIUrl":"10.1080/09553002.2024.2430246","url":null,"abstract":"<p><strong>Purpose: </strong>Buckwheat is a major traditional crop of hilly regions, capable of growing in adverse climatic conditions. During the survey, it was reported that prolonged consumption of buckwheat leads to digestive problems and numbness. The present study was conducted to study the effect of γ-irradiations on buckwheat to make them suitable for daily consumption.</p><p><strong>Materials and methods: </strong>Buckwheat seeds were irradiated by 100, 200, 300, 400, 500, 600, 700, and 800 Gy doses of γ-radiations, to access the phytoconstituent variability using standard methods.</p><p><strong>Results: </strong>Significant (<i>p</i> < 0.05) increase in total phenol, total flavonoid, total antioxidant activity, rutin, β-carotene, iron, calcium up to 6.23, 16.48, 18.62, 19.06, 8.08, 47.66, 32.74% in common buckwheat and 9.58, 16.66, 39.16, 9.19, 9.00, 53.99, 36.75% in tartary buckwheat was found by increasing doses of γ-radiations up to 800 Gy. Significant decrease was found in phytate, tannin, and oxalate content up to 18.92, 17.95, 15.32% in common buckwheat and 24.73, 19.72, 24.07% in tartary buckwheat.</p><p><strong>Conclusions: </strong>It can be concluded that 800 Gy dose of γ-radiation, maximally increased the nutritional value by significant (<i>p</i> < 0.05) increase in nutrients and their bioavailability. This makes buckwheat more amenable for daily consumption to fulfill RDA, by Himalayan population depending on traditional foods without any digestive problem. Furthermore, significant increase in rutin by γ-radiations will be useful to fulfill the demand of cosmetic and pharmaceutical industries. But minimization of reduction loss for some nutrients by γ-radiations is the thrust area for future research.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"73-84"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}