International journal of radiation biology最新文献

{"title":"Variability of radiation doses reconstructed by EPR in teeth of former United States nuclear workers.","authors":"Alexander Romanyukha, Keith Consani, Sergey Y Tolmachev","doi":"10.1080/09553002.2025.2519523","DOIUrl":"https://doi.org/10.1080/09553002.2025.2519523","url":null,"abstract":"<p><strong>Purpose: </strong>Our prior results showed that in the most cases, radiation doses measured by electron paramagnetic resonance (EPR) in tooth enamel samples significantly exceeded worksite reported doses. In an effort to understand causes of this discrepancy, we carried out EPR dose measurements in additional tooth samples collected from individuals studied before.</p><p><strong>Materials and methods: </strong>Tooth enamel samples from five tissue donors to the United States Transuranium and Uranium Registries were used in this study. EPR measurements were performed using ELEXYS 500 spectrometer and high purity germanium detectors were used to measure gamma-emitting radionuclides.</p><p><strong>Results: </strong>Significant variation of the EPR measured doses among multiple teeth collected from the same individuals was observed. These variations are potentially due to an additional exposure of the head/neck region as compared to the other parts of the body, e.g. torso where personal dosimeters are typically worn. The latter could explain very significant discrepancy of the doses, derived from EPR measurements and reported by worksites. With gamma-spectroscopy, no ¹³⁷Cs was detected in tooth roots.</p><p><strong>Conclusions: </strong>In several cases there was nonuniform exposure of the head of the teeth' donors which may explain the discrepancy between worksite reported and EPR reconstructed doses. Results of the gamma counting suggested that exposure from ¹³⁷Cs in the roots was not a factor in the observed discrepancy.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized combination methods for exploring novel space environment-responsive genes and their roles: insights from space-flown <i>C. elegans</i> and their implications for astronauts.","authors":"Zejun Li, Lei Zhao, Ge Zhang, Dong Mi, Yeqing Sun","doi":"10.1080/09553002.2025.2519561","DOIUrl":"https://doi.org/10.1080/09553002.2025.2519561","url":null,"abstract":"<p><strong>Purpose: </strong>By expanding the catalog of spaceflight-induced molecular signatures in <i>Caenorhabditis elegans</i>, we aim to identify key molecular features and potential mechanisms underlying space environment-induced health risks to astronauts using <i>C. elegans</i> as a model organism.</p><p><strong>Methods and materials: </strong>We employed an optimized combination algorithm that integrated two co-expression network analysis methods and four machine learning-based models to identify space environment-responsive genes (SEGs) in space-flown <i>C. elegans</i>. The expression levels and associated biological processes of human orthologues of identified <i>C. elegans</i> genes were further analyzed using data from the JAXA CFE and NASA Twins studies.</p><p><strong>Results: </strong>A total of 114 SEGs that were implicated in four biological processes, including DNA repair, metabolic process, reproductive and developmental process, and lifespan regulation in space-flown <i>C. elegans</i>. We obtained 19 SEGs as potential indicators associated with health risks of the space environment. Further, the human orthologues of <i>C. elegans</i> SEGs that also exhibited altered expression in the blood samples of astronauts.</p><p><strong>Conclusions: </strong>This study provides new insights into the molecular mechanisms behind spaceflight-induced health risks and highlights potential mechanistic targets for preventive measures. The findings suggest a conserved genetic response to space conditions between <i>C. elegans</i> and astronauts, offering valuable targets for mitigating the health risks of space exploration.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the alanine response to clinical proton and carbon ion beams.","authors":"Mattia Romeo, Alvaro de Farias Soares, Maria Cristina D'Oca, Mario Ciocca, Laura Mantovani, Riccardo Di Liberto, Alfredo Mirandola, Eleonora Rossi, Luca Maria Colombo Gomez, Maurizio Marrale","doi":"10.1080/09553002.2025.2523281","DOIUrl":"https://doi.org/10.1080/09553002.2025.2523281","url":null,"abstract":"<p><strong>Purposes: </strong>Hadrontherapy with proton and carbon ion scanning beams is an advanced radiation treatment modality mainly exploiting the finite range of those particles in the matter, to better spare critical organs close to the tumor volume as compared to photons. However, its complexity requires careful management of dosimetric uncertainties to guarantee patient safety. This study aims to reassess the suitability of alanine-based dosimetry for modern hadrontherapy applications.</p><p><strong>Materials and methods: </strong>Alanine pellets based on electron spin resonance (ESR) were used as dosimeters. The response was taken from the peak-to-peak amplitude and compared to the ionization chamber one. Dose response and dependence on energy, beam direction, and linear energy transfer (LET), for both pristine Bragg peak and spread-out Bragg peak (SOBP) were evaluated. The ESR ratio x/y was evaluated as a function of LET and microwave power. Photon irradiations were performed with a 6 MV linear accelerator at the San Matteo Hospital, while with charged particles at CNAO, both located in Pavia, Italy.</p><p><strong>Results: </strong>Alanine showed a linear dose-response for both protons and carbon ions in the range of 10-45 Gy. For carbon ions, a pronounced quenching effect in the Bragg peak and energy dependence were observed. Alanine effectiveness was reduced by up to 30% due to LET effects. Moreover, the use of the x/y ratio showed potential for LET differentiation.</p><p><strong>Conclusions: </strong>Alanine may be a promising dosimeter for hadrontherapy. However, further studies are required to investigate factors of correction due to the effects of LET and energy dependence.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Auger electron-emitting radionuclides for targeted DNA damage in mismatch repair-deficient cells: a theoretical study of ⁹⁹Rh- and ¹²³I-labeled metalloinsertors.","authors":"Alexandre França Velo, Lukas Carter, Michael Bellamy, Mike A Cornejo, Brian M Zeglis, John L Humm","doi":"10.1080/09553002.2025.2517328","DOIUrl":"10.1080/09553002.2025.2517328","url":null,"abstract":"<p><strong>Purpose: </strong>Preserving the integrity of the genome is critical to healthy cellular growth and development. Under normal circumstances, the eukaryotic mismatch repair (MMR) machinery is effective at detecting DNA polymerase errors and maintaining the fidelity of the genome. However, cells with inactivated MMR machinery are prone to the accumulation of mutations and tumorigenesis. This study explores the theoretical potential of rhodium-99- and iodine-123-labeled DNA metalloinsertors as Auger electron-emitting radiotherapeutics for cancers characterized by MMR deficiency.</p><p><strong>Materials and methods: </strong>A Monte Carlo code was developed in MATLAB^® to obtain Auger electron energy spectra for ⁹⁹Rh and ¹²³I. Using Geant4 track structure simulations, we determined the difference in effectiveness of these two Auger electron-emitting radionuclides in direct damage to DNA and the ability to produce double strand break damage (dsb) to the DNA comparing two different constructors 'G4EmDNAPhysics_option2' and 'G4EmDNAPhysics_option4'.</p><p><strong>Results: </strong>Differences in the Auger electron emission spectra of ⁹⁹Rh and ¹²³I arise from their electronic structure: ¹²³I favors more complex cascades and ultra-low-energy electrons, while ⁹⁹Rh produces electrons with energies more suited to DNA damage. Despite similar total electron yields, the emissions of ⁹⁹Rh are more effective at causing dsb (0.71 <i>vs.</i> 0.60 dsb/decay for ⁹⁹Rh and ¹²³I, respectively, using constructor 'G4EmDNAPhysics_option2' and 0.81 dsb/decay for ⁹⁹Rh <i>vs.</i> 0.71 dsb/decay for ¹²³I when using 'G4EmDNAPhysics_option4'.</p><p><strong>Conclusion: </strong>This theoretical study leverages both simulation and comparative analyses to identify ⁹⁹Rh as a promising Auger electron-emitting nuclide for radiotheranostics, as it offers superior DNA damage efficacy compared to ¹²³I.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-8"},"PeriodicalIF":2.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an electron spin resonance spectroscopy code for measuring carbonate radicals in tooth enamel and verification of its practicality using irradiated Japanese macaque teeth.","authors":"Takuma Yamashita, Teppei Hayashi, Yusuke Mitsuyasu, Kenta Ono, Satone Iwami, Yasushi Kino, Tsutomu Sekine, Toshitaka Oka, Atsushi Takahashi, Yoshinaka Shimizu, Mirei Chiba, Toshihiko Suzuki, Ken Osaka, Keiichi Sasaki, Taku Sato, Rio Isobe, Masatoshi Suzuki, Tomisato Miura, Manabu Fukumoto, Hisashi Shinoda","doi":"10.1080/09553002.2025.2510676","DOIUrl":"https://doi.org/10.1080/09553002.2025.2510676","url":null,"abstract":"<p><strong>Purpose: </strong>We developed a new computer program for the application of electron spin resonance (ESR) to dosimetry of wild animals related to the Fukushima Daiichi Nuclear Power Plant accident.</p><p><strong>Materials & methods: </strong>The ESR spectra of carbonate radicals and other inorganic radicals are calculated by the complete elliptic integral. A simulated annealing method is implemented for the parameter optimization. A cost function is designed to include the second derivative form of the microwave absorption spectrum to improve the fitting accuracy. As a testing ground for the developed code, we prepared tooth enamel samples from a Japanese macaque captured in a control area.</p><p><strong>Results: </strong>The developed code well reproduced the measured ESR spectrum. With a test spectrum, we demonstrated that the cost function that includes the second derivative form of the microwave absorption spectrum is helpful for the precise analysis of the low-dose enamel samples. The smoothness of the ESR spectrum plays an important role in utilizing this feature.</p><p><strong>Conclusion: </strong>The developed computer code can be used to analyze the ESR spectrum of tooth enamels of Japanese macaques. A precise analysis is essential to lower the detection limit and expand the applicability of ESR dosimetry. The code is independent of the computer operating system and is available publicly.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective centrifugation techniques for improving the frequency of metaphase spreads in lymphocytopenic patients.","authors":"Hyo Jin Yoon, Hae Young Ko, Su San Yang, Soon Woo Kwon, Minsu Cho, Jin Kyung Lee, Tomisato Miura, Yohei Fujishima, Donovan Anderson, Yang Hee Lee","doi":"10.1080/09553002.2025.2510674","DOIUrl":"https://doi.org/10.1080/09553002.2025.2510674","url":null,"abstract":"<p><strong>Purpose: </strong>Cytogenetic biodosimetry is used for radiation dose assessment by evaluating chromosomal aberrations in peripheral blood lymphocytes. However, high-dose radiation may cause low absolute lymphocyte counts (ALCs), making it difficult to obtain sufficient metaphase spreads for analysis. This study aimed to optimize centrifugation settings to enrich metaphase spreads, particularly for lymphocytopenic patients.</p><p><strong>Materials and methods: </strong>Peripheral blood samples from four healthy donors and one lymphocytopenic patient were collected. Lymphocytes were harvested using one of four centrifugation settings. After an additional low-speed centrifugation step (200 × <i>g</i> for 1 minute) in each experiment, we evaluated slide quality using mitotic index (MI) and metaphase frequency (MF), which were calculated by the number of metaphases and blasts using Metafer 4 software.</p><p><strong>Results: </strong>We established an automatic measurement method for metaphases and blasts, adjusting the settings of Metafer 4. In four healthy donors, the strongest centrifugation (Exp. 4, 879 × <i>g</i> for 5 minutes) yielded the highest number of 'all cells' after harvest. Incorporating an additional low-speed centrifugation step significantly increased MF by 1.5- to 2-fold across all settings, with the greatest improvement observed in Exp. 4. This approach was applied to a lymphocytopenic patient, resulting in a 3.5-fold improvement of MF and the production of high-quality slides. MI was not significantly affected by centrifugation.</p><p><strong>Conclusions: </strong>The combined high-speed and additional low-speed centrifugation method increased MF, improved slide quality by eliminating lower-density cells, and made it easier to analyze metaphase spreads. This method could be used for obtaining sufficient metaphase spreads in lymphocytopenic patients.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformation of the Chornobyl NPP cooling pond: radioecological situation and its impact on the blood system of small rodents.","authors":"Natalia Riabchenko, Alla Lypska, Natalia Rodionova, Hiroko Ishiniwa, Kenji Nanba, Olena Burdo","doi":"10.1080/09553002.2025.2505529","DOIUrl":"https://doi.org/10.1080/09553002.2025.2505529","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the radioecological consequences of the technogenic transformation of the Chornobyl NPP cooling pond aquatic ecosystem and its impact on the blood system of <i>Myodes glareolus</i>, a typical small rodent species in the Chornobyl exclusion zone.</p><p><strong>Materials and methods: </strong>Animals were captured in the drained areas of the cooling pond and nearby areas. Radiometric surveys of the animals' natural habitat and soil sampling were conducted. γ-β-spectrometry was used to measure radionuclide levels (¹³⁷Cs and ⁹⁰Sr) in soil and animal bodies. Absorbed dose rates were calculated. Blood smears, bone marrow and spleen imprints were prepared and stained using the standard Pappenheim method.</p><p><strong>Results: </strong>Activity of ¹³⁷Cs and ⁹⁰Sr in soil and animal samples, external/internal doses in animals were estimated. Radioecological assessment showed that radionuclide contamination in the drained areas did not exceed that of the adjacent territory. In exposed animals, similar hematopoietic alterations were observed, including disrupted differentiation and maturation of bone marrow cells, particularly in erythroid and granulocytic lineages. However, these blood abnormalities were less pronounced in animals from the drained zones.</p><p><strong>Conclusions: </strong>Draining the cooling pond, despite the expected high radionuclide concentrations in bottom sediments, did not cause significant changes in surface soil contamination. While bank voles showed deviations in blood parameters compared to reference values, differences between exposure groups were generally not significant. These findings support continued monitoring of radiobiological effects associated with the transforming of radiation-contaminated aquatic ecosystems into terrestrial.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative splicing in human cells exposed to ionizing radiation: a comprehensive review of ex vivo and in vivo studies.","authors":"Jerónimo Leberle, Marina Perona, Ananya Choudhury, Nicolas Bellora, Irene L Ibañez, Luisa V Biolatti","doi":"10.1080/09553002.2025.2505524","DOIUrl":"https://doi.org/10.1080/09553002.2025.2505524","url":null,"abstract":"<p><strong>Purpose: </strong>This study reviews how ionizing radiation (IR) induces alternative splicing (AS) in non-tumor and tumor cells under both ex vivo and in vivo irradiation conditions. The relevance and limitations of IR-induced AS in identifying potential biomarkers are highlighted for two main applications: biodosimetry and radiotherapy.</p><p><strong>Conclusions: </strong>Radiation promotes alterations in AS, which may differentially affect the response in both tumor and non-tumor cells. This response can occur in genes that change their overall expression as well as in those that remain unaltered in response to IR. Although cis-regulators modulate AS, trans-regulators like splicing factors are more involved in the IR response. Variants of key genes involved in the DNA damage response (DDR) are regulated in non-tumor cells while they are often deregulated in tumor cells favoring radioresistance. Identifying IR-induced AS variants could enhance the sensitivity of biodosimeters for dose estimation and biomarkers for radiosensitivity, offering potential strategies to personalize radiotherapy and improve outcomes. New and advanced sequencing technologies will allow variant identification important for the field of radiobiological research.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing major issues regarding the roles of biodosimetry in responding to a major nuclear incident: report of EPR BioDose 2024 roundtable discussion.","authors":"Matthias Port, Donovan Anderson, Harold M Swartz, Valerie Swee Ting Goh, Merriline M Satyamitra, Naduparambil K Jacob, Mattia Romeo, Ruth Wilkins, Ann Barry Flood","doi":"10.1080/09553002.2025.2498978","DOIUrl":"https://doi.org/10.1080/09553002.2025.2498978","url":null,"abstract":"<p><p>The roundtable discussion at EPR BioDose 2024 focused on identifying challenges for using biodosimetry in a large nuclear incident and exploring potential solutions to strengthen preparedness and response frameworks. This report outlines the major themes discussed, including advancements in techniques, challenges in scaling operations, and the future of biodosimetry in emergency response. Initiated by International Association of Biological and EPR Radiation Dosimetry (IABERD), a group of experts comprised of professionals in academia, government and other agencies, were asked to discuss the question: 'When and how should biodosimetry be used for an unplanned radiation explosion in the short or long term?' This question challenged participants to consider a range of scenarios, from immediate triage in the aftermath of an incident to long-term health monitoring and risk assessment. Panelists acknowledged that, while biodosimetry plays a crucial role in rapidly assessing exposure levels to guide medical response, its practical implementation can vary based on scale, resources, and timing. They emphasized that in the short term, methods that provide quick, large-scale screening are important, whereas long-term strategies might include more detailed biological assessments to understand cumulative effects and potential health risks. Despite the difficulty of a one-size-fits-all approach, the insights gathered aimed to inform strategies that balance speed, accuracy, and sustainability in biodosimetry practices. Finally, panelists emphasized the need for better communication about preparedness with the general public and healthcare providers, and a more collaborative approach that also takes into account evaluating the practicality of various methods for triage or guiding treatment.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdisciplinary team-based cancer research: a model for training the next generation of cancer researchers.","authors":"Dietmar W Siemann, Wendy Malorzo","doi":"10.1080/09553002.2025.2494546","DOIUrl":"https://doi.org/10.1080/09553002.2025.2494546","url":null,"abstract":"<p><strong>Purpose: </strong>Interdisciplinary team collaboration is a key element of discovery and advancement in oncology science and medicine. This fact is well-recognized by both laboratory and physician scientists and yet, most cancer research trainees are minimally exposed to and ill prepared in the collaboration skills required for them to be successful in the future. Similarly, near-peer mentoring, the benefits of which have been broadly published for precollegiate and undergraduate programs, is usually not a formal training component for doctoral and postdoctoral oncology trainees. At the University of Florida, the <b>Team-based Interdisciplinary Cancer Research Training</b> (<b>TICaRT) Program seeks to address this unmet need</b> by offering a unique opportunity for trainees to develop interdisciplinary skills in cancer research and gain collaborative expertise through team-based learning and near-peer mentoring.</p><p><strong>Conclusion: </strong>Active transdisciplinary research collaboration drives cancer discovery, knowledge, and treatment. Providing opportunities for trainees to participate in collaborative research experiences by incorporating team science and near-peer mentoring concepts as integral components of their training would greatly aid their preparation to become successful next-generation cancer researchers.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}