International journal of radiation biology最新文献

{"title":"Computed tomography-based pulmonary vasculature analysis of decreased lung perfusion after thoracic radiotherapy in patients with lung cancer.","authors":"Yu-Sen Huang, Jenny Ling-Yu Chen, Wei-Chun Ko, Yee-Fan Lee, Yeun-Chung Chang","doi":"10.1080/09553002.2024.2435316","DOIUrl":"10.1080/09553002.2024.2435316","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to quantitatively assess changes in lung perfusion after thoracic radiotherapy in lung cancer patients.</p><p><strong>Materials and methods: </strong>Patients underwent chest computed tomography (CT) for pulmonary vasculature analysis before radiotherapy and at 3 and 12 months after radiotherapy. The correlation between the percentage decrease in lung perfusion after radiotherapy and the delivered radiotherapy dose was analyzed.</p><p><strong>Results: </strong>The ipsilateral lung, where the primary tumor was located, received a significantly higher dose than the contralateral lung (mean dose: 22.9 Gy vs. 6.8 Gy). At 3 months, significant reductions in lung perfusion parameters were observed in the ipsilateral lung (total blood volume (TBV): 13.8%, blood volume in vessels with cross-sectional areas of ≤10 mm²: 12.6%, blood volume in vessels with cross-sectional areas of ≤5 mm²: 11.7%, subpleural vessel count: 21.1%, subpleural vessel area: 16.9%, and subpleural vessel density: 12.3%). Significant negative correlations between perfusion parameters and the radiation dose delivered to the ipsilateral lung were observed. For every 1-Gy increase in the mean dose for the ipsilateral lung, TBV decreased by 0.852% (<i>p</i> = .044), and for every 1% increase in the percentage of lung volume that received more than 20 Gy, TBV decreased by 0.402% (<i>p</i> = .048). The 3-year overall survival of the patients was 75%. No significant association between baseline perfusion parameters and survival was observed.</p><p><strong>Conclusions: </strong>Thoracic radiotherapy significantly reduced pulmonary perfusion, especially in the ipsilateral lung. The reduction in perfusion correlated with the radiation dose. These findings underscore the impact of radiation-induced damage on perfusion.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"35-43"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"γ-Radiations induced phytoconstituents variability in the grains of cultivated buckwheat species of Himalayan region.","authors":"Nidhi Joshi, Kuldip Chandra Verma, Sanjay Kumar Verma, Pawanesh Tamta","doi":"10.1080/09553002.2024.2430246","DOIUrl":"10.1080/09553002.2024.2430246","url":null,"abstract":"<p><strong>Purpose: </strong>Buckwheat is a major traditional crop of hilly regions, capable of growing in adverse climatic conditions. During the survey, it was reported that prolonged consumption of buckwheat leads to digestive problems and numbness. The present study was conducted to study the effect of γ-irradiations on buckwheat to make them suitable for daily consumption.</p><p><strong>Materials and methods: </strong>Buckwheat seeds were irradiated by 100, 200, 300, 400, 500, 600, 700, and 800 Gy doses of γ-radiations, to access the phytoconstituent variability using standard methods.</p><p><strong>Results: </strong>Significant (<i>p</i> < 0.05) increase in total phenol, total flavonoid, total antioxidant activity, rutin, β-carotene, iron, calcium up to 6.23, 16.48, 18.62, 19.06, 8.08, 47.66, 32.74% in common buckwheat and 9.58, 16.66, 39.16, 9.19, 9.00, 53.99, 36.75% in tartary buckwheat was found by increasing doses of γ-radiations up to 800 Gy. Significant decrease was found in phytate, tannin, and oxalate content up to 18.92, 17.95, 15.32% in common buckwheat and 24.73, 19.72, 24.07% in tartary buckwheat.</p><p><strong>Conclusions: </strong>It can be concluded that 800 Gy dose of γ-radiation, maximally increased the nutritional value by significant (<i>p</i> < 0.05) increase in nutrients and their bioavailability. This makes buckwheat more amenable for daily consumption to fulfill RDA, by Himalayan population depending on traditional foods without any digestive problem. Furthermore, significant increase in rutin by γ-radiations will be useful to fulfill the demand of cosmetic and pharmaceutical industries. But minimization of reduction loss for some nutrients by γ-radiations is the thrust area for future research.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"73-84"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages of single high-dose radiation therapy compared with conventional fractionated radiation therapy in overcoming radioresistance.","authors":"Yun-Suk Kwon, Phuong Anh Nguyen, Hai Yen Dao, Hyunsoo Jang, Soyoung Kim","doi":"10.1080/09553002.2024.2418493","DOIUrl":"10.1080/09553002.2024.2418493","url":null,"abstract":"<p><strong>Background: </strong>Radioresistance is a major clinical challenge in cancer treatment, as it reduces the effectiveness of radiation therapy (RT). While advances in radiation delivery have enabled the clinical use of high-dose hypofractionated RT, its impact on radioresistant tumors remains unclear. This study aimed to compare the effects of single high-dose RT with conventional fractionated RT on radioresistant breast cancer cells and explore the underlying mechanisms.</p><p><strong>Methods: </strong>Radioresistant cell lines were previously established by exposing SK-BR-3 and MCF-7 cells to 48 Gy and 70 Gy of radiation, respectively, in multiple fractions. We compared the effects of 2 Gy × 5 and 7 Gy × 1 fractions on these cells using clonogenic survival assays and western blot analysis. In vivo antitumor effects were assessed in SR tumor-bearing <i>BALB/c</i> mice irradiated with either 2 Gy × 5 or 7 Gy × 1 fractions.</p><p><strong>Results: </strong>7 Gy x1 was more efficient at killing radioresistant breast cancer cells than 2 Gy x5. Furthermore, the 7 Gy x1 fraction produced higher levels of reactive oxygen species (ROS) and decreased the expression of radioresistance factors such as p-STAT3, ACSL4, FOXM1, RAD51, Bcl-xL, and survivin. Consistent with the in vitro studies, the 7 Gy × 1 fraction also showed superior antitumor effects in SR tumor-bearing <i>BALB/c</i> mice.</p><p><strong>Conclusions: </strong>Single high-dose RT offers superior advantages over conventional fractionated RT in regard to overcoming radioresistance, supporting its potential as a promising treatment for recurrent tumors.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"44-55"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and characterization of gamma rays induced mutants for improved agro-morphological performance and harder grain texture in wheat (<i>Triticum aestivum</i> L.).","authors":"Amit Rana, Vijay Rana, Suman Bakshi, Vinod Kumar Sood","doi":"10.1080/09553002.2024.2425305","DOIUrl":"10.1080/09553002.2024.2425305","url":null,"abstract":"<p><strong>Purpose: </strong>Kernel texture plays a principal role in determining technological flour properties and end-use quality of wheat products. Hence, a multi-year mutation induction programme was conducted to isolate advanced wheat mutant lines with agro-morphologically superior performance, higher disease resistance and harder grain texture.</p><p><strong>Materials and methods: </strong>Radiation mutagenesis was employed in soft textured wheat variety HPW 89 using gamma rays dose of 250, 300 and 350 Gy (Co⁶⁰: BARC, Mumbai) and evaluated across M_1-5 generations. Promising superior mutants selected were evaluated during M₄ and M₅ generation for induced variability and trait association for agro-morphological and quality traits. The screened mutants were also determined for induced changes at genetic level using gene specific markers for puroindoline genes.</p><p><strong>Results: </strong>A total of 293 agro-morphologically superior mutants isolated showed significant genetic variation in the M₄ generation. Single kernel characterization system categorized 267 mutants (8.79-50.06) with higher grain hardness than the HPW 89 variety (7.39). Among these, 108 mutants were selected for agro-morphological and molecular characterization. Significant variations were found in these mutants in either <i>pina</i> and <i>pinb</i> or both puroindoline genes. Clustering among these mutants led to the formation of five clusters and a total of eleven mutants were found with better set of agro-morphological, disease resistance and quality traits.</p><p><strong>Conclusion: </strong>These mutants can serve as important genetic resource for developing harder texture bread wheat varieties in the future grain quality improvement programmes. These mutants will also bridge the need of bakers and millers' requirement of varieties with specific texture and quality.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"85-100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IEPA, a novel radiation countermeasure, alleviates acute radiation syndrome in rodents.","authors":"Radoslaw Wesolowski, Brian L Fish, Michael Eibl, Stella Bähr, Srishti Munjal Mehta, Maciej T Czajkowski, Tracy Gasperetti, Christie M Orschell, Corinna Asang, Nikita Singh, Heather A Himburg, Dirk Pleimes","doi":"10.1080/09553002.2024.2425312","DOIUrl":"10.1080/09553002.2024.2425312","url":null,"abstract":"<p><p>Repurposing therapeutic agents with existing clinical data is a common strategy for developing radiation countermeasures. IEPA (imidazolyl ethanamide pentandioic acid) is an orally bioavailable small molecule pseudopeptide with myeloprotective properties, a good clinical safety profile, and stable chemical characteristics facilitating stockpiling. Here, we evaluated IEPA's radiomitigative efficacy in the hematopoietic subsyndrome of acute radiation syndrome (H-ARS) using total-body irradiation (TBI) models in C57BL/6J mice and WAG/RijCmcr rats, applying various posology schemes and introducing syringe feeding of the IEPA formulation in the pudding. Additionally, we assessed IEPA in the delayed effects of acute radiation exposure (DEARE) model after partial-body irradiation (PBI) in WAG/RijCmcr rats. Endpoints included survival, body weight, hematology, and pulmonary parameters, depending on the model. Results from mouse and rat TBI models demonstrated survival improvements with repeated IEPA dosing at 10 mg/kg, with the largest benefits observed in the bi-daily (BID) treatment over the 30-day ARS phase in female rats. Survival across PBI-DEARE subsyndromes was comparable between IEPA and vehicle groups, though IEPA improved pulmonary parameters in female rats during the lung-DEARE phase. Sex-related differences in response to irradiation and IEPA were noted, with females showing a survival advantage. IEPA treatment is compatible with Neulasta® (Pegfilgrastim; PEG-G-CSF); adequately powered studies are needed to confirm the trend toward improved survival over standard care alone. IEPA is a promising development candidate as a medical countermeasure against the effects of acute radiation syndrome. Further confirmatory studies in small and large animal models should validate the robustness and translatability of preliminary rodent data on IEPA's radiomitigative efficacy.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technetium-99m radiolabeling of graphene quantum dots (GQDs) as a new probe for glioblastoma tumor imaging.","authors":"Maryam Mazaheri Tehrani, Mostafa Erfani, Mojtaba Amiri, Mostafa Goudarzi","doi":"10.1080/09553002.2024.2404460","DOIUrl":"10.1080/09553002.2024.2404460","url":null,"abstract":"<p><strong>Purpose: </strong>Cancer diagnosis involves a multi-step process. Accurate identification of the tumor, staging and development of cancer cells is crucial for selecting optimal treatments to minimize disease recurrence. Quantum dots (QDs) represent an exciting class of fluorescent nanoprobes in molecular detection and targeted tumor imaging.</p><p><strong>Materials and methods: </strong>In this study, graphene quantum dots (GQDs) were synthesized by pyrolysis of citric acid (CA) as a carbon precursor under high temperatures. The morphology of the obtained GQDs was first characterized using physical (TEM and DLS) and spectroscopic (fluorescence, FTIR and UV-Vis) methods. In the following,^99mTc-labeled GQDs were prepared in the presence of SnCl₂.2H₂O as a reducing agent between 95 and 100 °C. The biodistribution and tumor targeting efficiency of radiolabeled GQDs as a novel agent for C6 glioma tumor scintigraphy in an animal model were evaluated. Furthermore, organ uptake, human serum albumin binding and tumor accumulation were measured.</p><p><strong>Results: </strong>The TEM image of the prepared GQDs showed a relatively uniform size distribution in the range of diameter 6-9 nm and spherical shape. Radiolabeled GQDs showed a radiochemical yield of >97% (<i>n</i> = 3). Through incubation in human serum, almost 15% of ^99mTc-labeled GQDs degraded after 6 h. The amount of uptake in xenograft models of glioma C6 rats was 1.10 ± 0.36% of injection dose per gram after 1 h. The kidneys, intestinal and glioma tumor sites were observed via scintigraphy imaging.</p><p><strong>Conclusion: </strong>Our data suggest that ^99mTc-labeled GQDs, as a new radiotracer, efficiently accumulate in the tumor site and could be included as a radiotracer for detecting glioma tumors.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichostatin A mitigates acute and late effects of radiation in intestine by regulation of DNA damage repair and Wnt/TGFβ/Smad signaling.","authors":"Akshu Dahiya, Aliza Rehan, Paban K Agrawala, Ajaswrata Dutta","doi":"10.1080/09553002.2024.2430250","DOIUrl":"10.1080/09553002.2024.2430250","url":null,"abstract":"<p><strong>Purpose: </strong>Radiation accidents and misuse of nuclear weapons elevate the risk of development of acute life-threatening injuries as well as their late effects are noted in survivors. Currently, no countermeasure agents are available for the management of radiation-induced GI injury (RIGI) in humans. In the present study, the radiomitigative potential of Trichostatin A (TSA) was evaluated against acute and late RIGI.</p><p><strong>Methods: </strong>15 Gy gamma radiation was delivered to the whole abdomen of C57BL/6 mice, followed by intravenous TSA (150 ng/kg) administration after 1 h and 24 h. Acute changes were checked 24 h and 3.5 days post irradiation. Mice were monitored for development of fibrosis, survival for 1 year and alteration in different signaling pathways.</p><p><strong>Result: </strong>15 Gy abdominal irradiation activated the DNA damage marker (γ-H2AX) by nearly 3.2 ± 0.29 fold and regulated the repair proteins, XRCC1 and PARP1 in the intestine, which was differentially regulated by TSA. The Wnt signaling pathway and stem cell proliferation in the intestine were also positively regulated by TSA. The TSA administered mice demonstrated improved intestinal morphology. 12.5% of TSA administered mice survived upto 1 year whereas 100% of 15 Gy exposed mice died by 6 months. The surviving mice that had received TSA showed reduced intestinal fibrosis than 15 Gy group, possibly via downregulation of TGFβ/Smad signaling.</p><p><strong>Conclusion: </strong>The findings suggest that TSA have the potential to mitigate both acute and late effects of radiation in the intestine and can be explored as promising agent in the management of RIGI.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"15-27"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin as a radioprotective agent against flattening filter and flattening filter-free beam in radiotherapy-induced lung tissue damage.","authors":"Zuhal Özer Simsek, Serhat Aras, Makbule Cikrikcioglu, Kursad Nuri Baydili, Mustafa Cortuk","doi":"10.1080/09553002.2024.2381492","DOIUrl":"10.1080/09553002.2024.2381492","url":null,"abstract":"<p><strong>Background: </strong>Radiotherapy is a widely used treatment method in oncology, applied by delivering high-energy particles or waves to the tumor tissue. Although tumor cells are targeted with radiotherapy, it can cause acute or long-term damage to healthy tissues. Therefore, the preservation of healthy tissues has been an important subject of various scientific researches. Melatonin has been shown to have a radioprotective effect on many tissues and organs such as liver, parotid gland, brain, and testicles. This study aimed to evaluate the protective effect of melatonin against the radiation at various doses and rates administered to the lung tissue of healthy mice.</p><p><strong>Methods: </strong>This study was a randomized case-control study conducted with 80 rats comprising 10 groups with eight animals per group. Of the 10 groups, first is the control group, which is not given any melatonin, and second is the group that does not receive RT, which is given only melatonin, and the other eight groups are RT groups, four with melatonin and four without melatonin.</p><p><strong>Results: </strong>There was no statistical difference in terms of histopathological findings in the lung tissue between the second group, which did not receive radiotherapy and received only melatonin, and the control group. Lung damage due to radiotherapy was statistically significantly higher in the groups that did not receive melatonin compared to the groups that received melatonin.</p><p><strong>Conclusions: </strong>This study revealed that melatonin has a protective effect against the cytotoxic damage of RT in rats receiving RT.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The combination of microwave hyperthermia with TIPE2 impedes the growth of orthotopic colon cancer.","authors":"Qingqing Yu, Lingdi Li, Weixing Mo, Linfang Zhao, Lidan Zhang, Ke Zhang, Rongjun Tang","doi":"10.1080/09553002.2024.2435324","DOIUrl":"https://doi.org/10.1080/09553002.2024.2435324","url":null,"abstract":"<p><strong>Background: </strong>Colon cancer (CC) is the main fatal disease of humans. Microwave hyperthermia (MH) is an adjuvant therapy for diverse cancers. Tumor necrosis factor-α induced protein-8-like 2 (TIPE2) is a tumor suppressor. However, the effect of MH combined with TIPE2 on CC remains unclear.</p><p><strong>Methods: </strong>The orthotopic CC mouse model was constructed by mouse CC CT26-Luc cells, and mice were randomized into control, model (CT26-Luc), CT26-Luc + Vector, CT26-Luc + TIPE2, CT26-Luc + MH, and CT26-Luc + MH+TIPE2 groups (<i>n</i> = 6). Tumor growth pretreatment and post-treatment by <i>in vivo</i> fluorescence image analysis was detected. TIPE2 expression and cell transfection efficiency was detected by qRT-PCR and western blot. The pathological changes by HE staining, apoptosis by TUNEL staining, serum inflammatory factors by ELISA, TIPE2 expression by immunohistochemistry, and NF-κB signaling by western blot was performed.</p><p><strong>Results: </strong>Paracancerous tissues showed higher TIPE2 expression than in CC tissues. CT26-Luc + TIPE2, CT26-Luc + MH, and CT26-Luc + MH+TIPE2 groups reduced tumor growth, tumor cell infiltration, and increased apoptosis. CT26-Luc + TIPE2 group had lower NF-κB, TNF-α, IL-1β, IL-6, p-p65, and p-IKK expression, and elevated TIPE2 and IkB expression, which was reversed by CT26-Luc + MH group. Moreover, CT26-Luc+MH+TIPE2 group showed opposite effects on the above factor expression of CT26-Luc+MH group.</p><p><strong>Conclusions: </strong>Combination of MH with TIPE2 could impede CC tumor growth, providing scientific bases for its clinical application in CC treatment.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testicular exposure to ionizing radiation and sperm epigenetic alterations as possible mechanisms of hereditary effects: perspectives from the viewpoint of radiation protection.","authors":"Hisanori Fukunaga, Nobuyuki Hamada","doi":"10.1080/09553002.2024.2440860","DOIUrl":"https://doi.org/10.1080/09553002.2024.2440860","url":null,"abstract":"<p><strong>Purpose: </strong>Since the genotoxicity of ionizing radiation was demonstrated in the 1920s, its hereditary effects have remained a serious concern for human society. The International Commission on Radiological Protection has highlighted the need for appropriate protection against hereditary effects of radiation in humans. In this paper, we review the literature on the possible multigenerational and transgenerational effects following testicular exposure to radiation, focusing on sperm epigenetic alterations as possible mechanisms.</p><p><strong>Results: </strong>This mini-review highlights that hereditary effects following testicular exposure occur via epigenetic changes of germ cells in animal models, providing implications on human radiation protection.</p><p><strong>Conclusions: </strong>A great amount of epigenomic research data has emerged rapidly since the beginning of this century; thus, a revision of the radiological protection protocols against the hereditary effects of radiation would be no longer inevitable. The collection and analysis of evidence on these effects must be enhanced and further accelerated to formulate appropriate protection protocols in the future.</p>","PeriodicalId":94057,"journal":{"name":"International journal of radiation biology","volume":" ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}