International journal of oral and maxillofacial surgery最新文献_第4页

Effectiveness of Aloe vera in the treatment of oral mucositis: a systematic review and meta-analysis of randomized controlled trials. 芦荟治疗口腔黏膜炎的有效性：随机对照试验的系统回顾和荟萃分析。

International journal of oral and maxillofacial surgery Pub Date : 2025-02-04 DOI: 10.1016/j.ijom.2025.01.015

D Cássia-Santos, C K C Santos, L T Fernandes, G Q Carvalho, S N de Aquino, C A A Lemos

{"title":"Effectiveness of Aloe vera in the treatment of oral mucositis: a systematic review and meta-analysis of randomized controlled trials.","authors":"D Cássia-Santos, C K C Santos, L T Fernandes, G Q Carvalho, S N de Aquino, C A A Lemos","doi":"10.1016/j.ijom.2025.01.015","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.015","url":null,"abstract":"Oral mucositis (OM) is a common complication of cancer patients. A systematic review and meta-analysis assessed the effectiveness of Aloe vera (AV) in the treatment of OM. The population included cancer patients undergoing radiotherapy or chemotherapy, treated for OM with AV. A search following the PICOS strategy, with specific keywords, identified randomized controlled trials (RCTs) published up to September 2024. Seven RCTs involving 355 participants, 170 in the intervention (AV) groups (mean age 39.7 years, standard deviation 23.9 years) and 185 in control groups (mean age 39.0 years, standard deviation 23.5 years), were included. A significant difference in the improvement of severe mucositis cases (grades 3 and 4) was observed with the use of AV compared to control (placebo, sodium bicarbonate, or benzydamine) (odds ratio 0.32, 95% confidence interval 0.15-0.70, P = 0.004). Considering the moderate heterogeneity observed (I2 = 36%, P = 0.15), a subgroup analysis was conducted. A subgroup analysis showed significant improvement in grade 3 and 4 OM for AV versus placebo (odds ratio 0.22, 95% CI 0.11-0.44, P < 0.001), but not compared with sodium bicarbonate or benzydamine. The results suggest that AV may be beneficial for cancer patients undergoing radiotherapy or chemotherapy, leading to improvements in the more severe stages of OM.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra-articular injection of orthobiologics for temporomandibular joint osteoarthritis: a systematic review of randomized controlled trials. 关节内注射骨科治疗颞下颌关节骨性关节炎：随机对照试验的系统综述。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-30 DOI: 10.1016/j.ijom.2025.01.008

Y M Sillmann, J L G C Monteiro, M Haugstad, B Burris, D A Keith, S Handa, F P S Guastaldi

{"title":"Intra-articular injection of orthobiologics for temporomandibular joint osteoarthritis: a systematic review of randomized controlled trials.","authors":"Y M Sillmann, J L G C Monteiro, M Haugstad, B Burris, D A Keith, S Handa, F P S Guastaldi","doi":"10.1016/j.ijom.2025.01.008","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.008","url":null,"abstract":"Temporomandibular joint (TMJ) osteoarthritis (OA) leads to pain, limited jaw function, and bite changes. When non-invasive treatments fail, minimally invasive procedures like TMJ arthrocentesis with saline and hyaluronic acid (HA) injections are commonly used. Orthobiologics, including platelet-rich plasma (PRP) and cell-derived products, have gained attention for their potential to enhance tissue healing. This review aimed to compare the outcomes of orthobiologic injections with HA injections following arthrocentesis in TMJ-OA treatment. A systematic search, following PRISMA guidelines, identified nine studies (403 patients). Risk of bias was assessed using the Cochrane Risk of Bias Tool. PRP and cell-derived products showed potential benefits in reducing TMJ pain and improving maximum mouth opening (MMO). However, three of four studies comparing PRP with HA found no significant difference between the two. In contrast, cell-derived orthobiologics demonstrated significantly greater improvements in TMJ pain and MMO compared to HA. Risk of bias varied, with some studies showing moderate to high levels. This review highlights the potential but inconsistent benefits of orthobiologics in treating TMJ-OA. While cell-derived orthobiologics appear promising, PRP did not demonstrate superiority over HA. Further high-quality studies are needed to validate these findings.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanisms of temporomandibular joint degeneration in large animal models. 大型动物模型中颞下颌关节退化的分子机制。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-30 DOI: 10.1016/j.ijom.2025.01.007

J L G C Monteiro, Y M Sillmann, T M Kambakhsh, M Bei, F P S Guastaldi

{"title":"Molecular mechanisms of temporomandibular joint degeneration in large animal models.","authors":"J L G C Monteiro, Y M Sillmann, T M Kambakhsh, M Bei, F P S Guastaldi","doi":"10.1016/j.ijom.2025.01.007","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.007","url":null,"abstract":"The aim of this scoping review was to summarize the results of large animal models investigating the molecular mechanisms of temporomandibular joint degenerative diseases (TMJ-DD). A search of the PubMed/MEDLINE, Embase, and Cochrane Library databases was performed, up to April 2024, using specific terms related to large animals and TMJ-DD. Identified studies had to be published in English. Two reviewers independently selected articles based on the inclusion criteria, with disagreements resolved by a senior author. Compliance with the ARRIVE guidelines was assessed for all studies, evaluating adherence to reporting standards across 21 checklist items. The search yielded 649 non-duplicate articles, of which 616 were excluded after title and abstract screening . The remaining 33 articles and one additional study identified in a hand-search underwent full-text review . Ultimately, seven studies were included, with three focusing on sheep, two on horses, and two on pigs. This review summarizes the biological markers involved in TMJ-DD and discusses their relevance in developing targeted and minimally invasive strategies to prevent the initiation and/or progression of joint disease.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of unfavourable osteotomy on skeletal stability and temporomandibular joint symptoms in sagittal split ramus osteotomy. 矢状裂支截骨术中不良截骨对骨骼稳定性和颞下颌关节症状的影响。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-29 DOI: 10.1016/j.ijom.2025.01.011

S Ohba, R Shido, T Naruse, S Narahara, T Yamada

{"title":"Influence of unfavourable osteotomy on skeletal stability and temporomandibular joint symptoms in sagittal split ramus osteotomy.","authors":"S Ohba, R Shido, T Naruse, S Narahara, T Yamada","doi":"10.1016/j.ijom.2025.01.011","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.011","url":null,"abstract":"This study was performed to investigate the impact of the split line on postoperative stability and temporomandibular joint (TMJ) disorders (TMD) after sagittal split ramus osteotomy. Skeletal Class III malocclusion patients who underwent mandibular osteotomy with/without plate fixation between August 2008 and March 2023 were enrolled retrospectively. The osteotomy lines were divided into original sagittal split ramus (SSRO), short lingual (SLO), and short buccal (SBO) osteotomies. Skeletal stability was evaluated, and TMDs were assessed preoperatively. Overall, 135 patients (270 TMJs) (87 female, 48 male; mean age 23.7 ± 7.8 years) were included. Mean mandibular setback was 6.2 ± 2.9 mm. Skeletal stability was observed in all patients. TMD were recorded in 47 joints (17.4%) preoperatively and 15 joints (5.6%) postoperatively. When TMD were compared between joints with and without plate fixation, preoperative TMD was found to be improved in non-fixed joints (P = 0.004). On multivariate analysis, segment fixation (P = 0.040), the osteotomy line (SBO vs SLO/SSRO, P = 0.043), and preoperative TMD (P = 0.030) were associated with postoperative TMD. The results of this study suggest that no plate fixation after mandibular osteotomy may be beneficial when the split line is SBO or preoperative TMD is observed.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automatic segmentation of the midfacial bone surface from ultrasound images using deep learning methods. 利用深度学习方法从超声图像中自动分割面中骨表面。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-28 DOI: 10.1016/j.ijom.2025.01.012

M Yuan, B Jie, R Han, J Wang, Y Zhang, Z Li, J Zhu, R Zhang, Y He

{"title":"Automatic segmentation of the midfacial bone surface from ultrasound images using deep learning methods.","authors":"M Yuan, B Jie, R Han, J Wang, Y Zhang, Z Li, J Zhu, R Zhang, Y He","doi":"10.1016/j.ijom.2025.01.012","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.012","url":null,"abstract":"With developments in computer science and technology, great progress has been made in three-dimensional (3D) ultrasound. Recently, ultrasound-based 3D bone modelling has attracted much attention, and its accuracy has been studied for the femur, tibia, and spine. The use of ultrasound allows data for bone surface to be acquired non-invasively and without radiation. Freehand 3D ultrasound of the bone surface can be roughly divided into two steps: segmentation of the bone surface from two-dimensional (2D) ultrasound images and 3D reconstruction of the bone surface using the segmented images. The aim of this study was to develop an automatic algorithm to segment the midface bone surface from 2D ultrasound images based on deep learning methods. Six deep learning networks were trained (nnU-Net, U-Net, ConvNeXt, Mask2Former, SegFormer, and DDRNet). The performance of the algorithms was compared with that of the ground truth and evaluated by Dice coefficient (DC), intersection over union (IoU), 95th percentile Hausdorff distance (HD95), average symmetric surface distance (ASSD), precision, recall, and time. nnU-Net yielded the highest DC of 89.3% ± 13.6% and the lowest ASSD of 0.11 ± 0.40 mm. This study showed that nnU-Net can automatically and effectively segment the midfacial bone surface from 2D ultrasound images.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between maxillary defect and facial asymmetry. 上颌缺损与面部不对称的关系。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-26 DOI: 10.1016/j.ijom.2025.01.013

Y Huang, W Wang, B X Gu, Z Y Wu, X H Zhou, Z G Cai, J Zhang

{"title":"Correlation between maxillary defect and facial asymmetry.","authors":"Y Huang, W Wang, B X Gu, Z Y Wu, X H Zhou, Z G Cai, J Zhang","doi":"10.1016/j.ijom.2025.01.013","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.013","url":null,"abstract":"The aim of this study was to evaluate the correlation between maxillary defects and facial asymmetry, and to establish categories for visual perception of facial asymmetry. The facial data of 47 patients who underwent maxillary resection due to tumors were captured using stereophotogrammetry. Facial asymmetry was measured using a landmark-independent method and assessed with a Likert scale. Facial asymmetry was classified into three grades (I-III) based on visual perception. Statistically significant differences (P < 0.001) were found in the asymmetry of the suborbital, zygomatic, buccal, and superolabial areas among the different visual perception categories, and the symmetry of these areas significantly influenced the visual perception (P < 0.001). The maxillary defect magnitude significantly influenced facial asymmetry perception (P < 0.001). Substantial statistical variations (P < 0.001) in the asymmetry of four facial areas, excluding the masseteric and nasal areas, across the different classes of maxillary defect were noted. Maxillary defects significantly affect the midface soft tissue symmetry. Reconstruction should focus on sufficient soft tissue support in the zygomatic, buccal, suborbital, and superolabial areas. Corrective measures are generally unnecessary for grade I asymmetry. For grade II asymmetry, reconstruction can be decided individually. For grade III asymmetry, reconstruction is essential.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatofibrosarcoma protuberans arising in the lower labial mucosa: a case report and literature review. 下唇黏膜生隆突性皮肤纤维肉瘤1例并文献复习。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-24 DOI: 10.1016/j.ijom.2025.01.009

K Chihara, K Yamagata, K Maeda, T Namai

{"title":"Dermatofibrosarcoma protuberans arising in the lower labial mucosa: a case report and literature review.","authors":"K Chihara, K Yamagata, K Maeda, T Namai","doi":"10.1016/j.ijom.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.009","url":null,"abstract":"Dermatofibrosarcoma protuberans (DFSP) is a low-grade, malignant, spindle cell tumour with an infiltrative growth pattern and a high local recurrence rate. Cases of oral DFSP are rare. This report describes a case of DFSP occurring in the labial mucosa. A 21-year-old Japanese man was referred with a recurrent mass on the labial mucosa. Oral examination revealed an indurated tumour of 10 mm, extending from the lower labial mucosa to the labial commissure. The lesion was resected with a surgical margin of >10 mm from the induration, under general anaesthesia. The full-thickness labial mucosa to the cheek, with overlying skin and labial commissure, was resected. Pathologically, spindle-shaped cells with pale eosinophilic cytoplasm were observed. Most of the tumour cells exhibited mild to moderate nuclear atypia and were positive for α-smooth muscle actin and CD34 on immunohistochemistry. Based on these findings, a pathological diagnosis of DFSP was made. The postoperative course was uneventful, and no recurrence was observed for over a year. Oral DFSP is extremely rare and challenging to diagnose, and DFSP of the labial mucosa, as reported here, is exceptionally rare. Resection of this locally invasive tumour with a clear margin is important for a good prognosis.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computed tomography-based findings and severity of temporomandibular joint osteoarthritis are associated with the development of skeletal mandibular retrusion. 基于计算机断层扫描的结果和颞下颌关节骨性关节炎的严重程度与下颌骨后缩的发展有关。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-24 DOI: 10.1016/j.ijom.2025.01.003

H Miyagishima, K Fujita, Y Yamashita, H Takasu, M Hirota, K Mitsudo

{"title":"Computed tomography-based findings and severity of temporomandibular joint osteoarthritis are associated with the development of skeletal mandibular retrusion.","authors":"H Miyagishima, K Fujita, Y Yamashita, H Takasu, M Hirota, K Mitsudo","doi":"10.1016/j.ijom.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.003","url":null,"abstract":"The aim of this study was to clarify the relationship between the severity of condylar osteoarthritis (OA) and skeletal mandibular retrusion. Three-dimensional cephalometric characteristics of skeletal mandibular retrusion were analysed using computed tomography scans from 15 patients with OA and 15 without OA. Mandibular, dental, and condylar-related factors were evaluated. Severity was scored by counting findings of cysts, erosion, atrophy, osteophytes, and sclerosis (score of 1 for the presence of each). The OA group was further divided into mild and moderate OA according to the total severity score of both condyles. The mean condylar volume was significantly lower in OA (851.1 mm3) than in non-OA (1151.3 mm3) (P < 0.001). A decrease in volume was significantly correlated with the number of radiographic OA findings (P = 0.012). Findings seen in mild OA were mostly cysts and erosion, while all findings were identified in moderate OA. The measured factors did not differ significantly between the mild OA and non-OA groups, whereas many mandible-related factors differed significantly between the moderate OA and non-OA groups. A significantly lower volume of the condyle was observed in moderate OA compared to non-OA (P < 0.001), suggesting that the appearance of atrophy, osteophytes, and sclerosis worsened OA from mild to moderate, and correspondingly, mandibular retrusion became apparent.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant promoter methylation of CTHRC1 gene and its clinicopathological characteristics in head and neck cancer. 头颈癌CTHRC1基因启动子甲基化异常及其临床病理特征

International journal of oral and maxillofacial surgery Pub Date : 2025-01-24 DOI: 10.1016/j.ijom.2025.01.005

A R Kumar, B Kannan, S Girija As, V P Jayaseelan, P Arumugam

{"title":"Aberrant promoter methylation of CTHRC1 gene and its clinicopathological characteristics in head and neck cancer.","authors":"A R Kumar, B Kannan, S Girija As, V P Jayaseelan, P Arumugam","doi":"10.1016/j.ijom.2025.01.005","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.005","url":null,"abstract":"Head and neck squamous cell carcinoma (HNSCC) is genetically complex and difficult to treat. Detection in the early stage is challenging, leading to diagnosis at advanced stages with limited treatment options. This study examined the collagen triple helix repeat containing 1 gene (CTHRC1) as a potential biomarker and therapeutic target in HNSCC. Despite documented CTHRC1 upregulation in various cancers, the underlying causes remain unclear. The objective was to investigate potential epigenetic regulation of CTHRC1 expression through the analysis of promoter methylation. CTHRC1 DNA methylation, mRNA, and its protein expression were analysed using The Cancer Genome Atlas (TCGA) HNSCC cohort and oral squamous cell carcinoma (OSCC) patient samples. Functional analysis included scrutinizing the protein-protein interaction network and associations with DisGeNET (disease gene network). Various statistical methods were employed for analysis. HNSCC tumours exhibited significant hypomethylation of CTHRC1 DNA, correlating with advanced disease features. Elevated mRNA and protein expression of CTHRC1 further support its role in disease progression. High CTHRC1 gene expression was associated with a poorer prognosis. The protein interaction network implicated crucial pathways in cancer development and links to oral submucous fibrosis. Despite the limitations of this study, including the use of retrospective data and need for functional experiments, CTHRC1 shows potential as a prognostic predictor and target for therapeutic applications in HNSCC, paving the way for further research and improved patient management.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-tricalcium phosphate patient-specific gap implants in bilateral sagittal split osteotomy: an innovative treatment method to enhance the mandibular border contour. Part 1: concept and workflow. 双侧矢状面劈裂截骨术中β -磷酸三钙患者特异性间隙种植体：一种增强下颌边缘轮廓的创新治疗方法。第1部分：概念和工作流。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-22 DOI: 10.1016/j.ijom.2025.01.004

G R J Swennen, A Aksu, F Reinauer, L Pottel, Y Weinberg

{"title":"Beta-tricalcium phosphate patient-specific gap implants in bilateral sagittal split osteotomy: an innovative treatment method to enhance the mandibular border contour. Part 1: concept and workflow.","authors":"G R J Swennen, A Aksu, F Reinauer, L Pottel, Y Weinberg","doi":"10.1016/j.ijom.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.004","url":null,"abstract":"Antegonial notching can occur after bilateral sagittal split osteotomy (BSSO) and may lead to unpleasant aesthetic outcomes in both young and older patients. This clinical study presents a new concept to potentially overcome this problem and describes the workflow. Beta-tricalcium phosphate patient-specific gap implants (β-TCP gap-PSIs) are biocompatible and resorbable bone grafts that are placed in the space of the osteotomy gap during orthognathic procedures; they are virtually planned and printed in 3D. Between July 9, 2017 and July 31, 2018, 14 patients received bilateral β-TCP gap-PSIs during BSSO procedures. Nine were female (64.3%) and five were male (35.7%); mean age at surgery was 32.4 ± 12.7 years and the mean sagittal advancement gap was 9.4 ± 1.74 mm. The immediate postoperative position of the β-TCP implants, as well as early and long-term complications were evaluated; the clinical follow-up was 5 years. Intraoperative placement of the β-TCP implants was achieved without early complications, and the mandibular border contour was rated as very good or good in 82.1% of sides. Two minor long-term complications occurred, resulting in a total grafting success rate of 92.9%. In conclusion, this initial study (part 1) showed the potential of the β-TCP gap-PSI concept in BSSO procedures to prevent antegonial notching, which is currently underestimated and underreported. However, further extensive quantitative assessment is mandatory and will be presented in part 2.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0