International journal of oral and maxillofacial surgery最新文献_第3页

Aberrant promoter methylation of CTHRC1 gene and its clinicopathological characteristics in head and neck cancer.

International journal of oral and maxillofacial surgery Pub Date : 2025-01-24 DOI: 10.1016/j.ijom.2025.01.005

A R Kumar, B Kannan, S Girija As, V P Jayaseelan, P Arumugam

{"title":"Aberrant promoter methylation of CTHRC1 gene and its clinicopathological characteristics in head and neck cancer.","authors":"A R Kumar, B Kannan, S Girija As, V P Jayaseelan, P Arumugam","doi":"10.1016/j.ijom.2025.01.005","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.005","url":null,"abstract":"Head and neck squamous cell carcinoma (HNSCC) is genetically complex and difficult to treat. Detection in the early stage is challenging, leading to diagnosis at advanced stages with limited treatment options. This study examined the collagen triple helix repeat containing 1 gene (CTHRC1) as a potential biomarker and therapeutic target in HNSCC. Despite documented CTHRC1 upregulation in various cancers, the underlying causes remain unclear. The objective was to investigate potential epigenetic regulation of CTHRC1 expression through the analysis of promoter methylation. CTHRC1 DNA methylation, mRNA, and its protein expression were analysed using The Cancer Genome Atlas (TCGA) HNSCC cohort and oral squamous cell carcinoma (OSCC) patient samples. Functional analysis included scrutinizing the protein-protein interaction network and associations with DisGeNET (disease gene network). Various statistical methods were employed for analysis. HNSCC tumours exhibited significant hypomethylation of CTHRC1 DNA, correlating with advanced disease features. Elevated mRNA and protein expression of CTHRC1 further support its role in disease progression. High CTHRC1 gene expression was associated with a poorer prognosis. The protein interaction network implicated crucial pathways in cancer development and links to oral submucous fibrosis. Despite the limitations of this study, including the use of retrospective data and need for functional experiments, CTHRC1 shows potential as a prognostic predictor and target for therapeutic applications in HNSCC, paving the way for further research and improved patient management.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-tricalcium phosphate patient-specific gap implants in bilateral sagittal split osteotomy: an innovative treatment method to enhance the mandibular border contour. Part 1: concept and workflow.

International journal of oral and maxillofacial surgery Pub Date : 2025-01-22 DOI: 10.1016/j.ijom.2025.01.004

G R J Swennen, A Aksu, F Reinauer, L Pottel, Y Weinberg

{"title":"Beta-tricalcium phosphate patient-specific gap implants in bilateral sagittal split osteotomy: an innovative treatment method to enhance the mandibular border contour. Part 1: concept and workflow.","authors":"G R J Swennen, A Aksu, F Reinauer, L Pottel, Y Weinberg","doi":"10.1016/j.ijom.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.004","url":null,"abstract":"Antegonial notching can occur after bilateral sagittal split osteotomy (BSSO) and may lead to unpleasant aesthetic outcomes in both young and older patients. This clinical study presents a new concept to potentially overcome this problem and describes the workflow. Beta-tricalcium phosphate patient-specific gap implants (β-TCP gap-PSIs) are biocompatible and resorbable bone grafts that are placed in the space of the osteotomy gap during orthognathic procedures; they are virtually planned and printed in 3D. Between July 9, 2017 and July 31, 2018, 14 patients received bilateral β-TCP gap-PSIs during BSSO procedures. Nine were female (64.3%) and five were male (35.7%); mean age at surgery was 32.4 ± 12.7 years and the mean sagittal advancement gap was 9.4 ± 1.74 mm. The immediate postoperative position of the β-TCP implants, as well as early and long-term complications were evaluated; the clinical follow-up was 5 years. Intraoperative placement of the β-TCP implants was achieved without early complications, and the mandibular border contour was rated as very good or good in 82.1% of sides. Two minor long-term complications occurred, resulting in a total grafting success rate of 92.9%. In conclusion, this initial study (part 1) showed the potential of the β-TCP gap-PSI concept in BSSO procedures to prevent antegonial notching, which is currently underestimated and underreported. However, further extensive quantitative assessment is mandatory and will be presented in part 2.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TNF-α polymorphism in oral cancer and oral potentially malignant disorders: meta-analysis and investigation as a potential tool to determine individual susceptibility and the prognosis. 口腔癌和口腔潜在恶性疾病中的TNF-α多态性：作为确定个体易感性和预后的潜在工具的荟萃分析和调查

International journal of oral and maxillofacial surgery Pub Date : 2025-01-17 DOI: 10.1016/j.ijom.2025.01.002

A Jain, N Sivakumar, P Sharma, S John, S Gupta

{"title":"TNF-α polymorphism in oral cancer and oral potentially malignant disorders: meta-analysis and investigation as a potential tool to determine individual susceptibility and the prognosis.","authors":"A Jain, N Sivakumar, P Sharma, S John, S Gupta","doi":"10.1016/j.ijom.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.002","url":null,"abstract":"There is increasing evidence that tumour necrosis factor alpha (TNF-α) gene polymorphisms may promote development and spread of cancer through transitions at different loci that lead to its altered expression. However, data on TNF-α gene polymorphisms in oral cancer remain highly controversial. This meta-analysis was performed to determine the impact of TNF-α gene polymorphisms on oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). An electronic search was conducted in the PubMed, Cochrane Library, Google Scholar, and Web of Science databases to identify original articles reporting TNF-α polymorphism in OSCC and OPMD. The articles were examined by two independent authors. Data from the included articles were compiled and tabulated. Risk of bias was analysed. Overall, 11 eligible articles that included 1070 cases of OSCC and 641 cases of OPMD in which TNF-α polymorphism was studied, were included for quantitative analysis. It was found that both TNF-α -308 and -238 polymorphisms were significantly associated with the development of oral cancer. TNF-α polymorphism was significantly associated with OSCC and OPMD. Moreover, in polymorphisms of TNF-α at both -308 and -238, the G allele, especially the homozygous form (GG), was found to be associated with oral cancer.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of orthognathic surgery on the cheek area using the Barcelona line. 使用巴塞罗那线的正颌手术对脸颊区域的影响。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-15 DOI: 10.1016/j.ijom.2024.11.002

J S Vivas-Castillo, A Valls-Ontañón, O L Haas Junior, M Giralt-Hernando, G M Ragucci, F J Hernández-Alfaro

{"title":"Impact of orthognathic surgery on the cheek area using the Barcelona line.","authors":"J S Vivas-Castillo, A Valls-Ontañón, O L Haas Junior, M Giralt-Hernando, G M Ragucci, F J Hernández-Alfaro","doi":"10.1016/j.ijom.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.ijom.2024.11.002","url":null,"abstract":"A facial appearance of premature aging due to poor bone support of the soft tissues is frequently found in patients with midface hypoplasia. This study was performed to evaluate the changes in the soft tissues of the cheek area in patients subjected to bimaxillary orthognathic surgery. The cheek line angle and length of 27 consecutive patients who underwent bimaxillary surgery, were measured on cone beam computed tomography scans obtained before surgery and at 1 and 12 months after surgery using 3D software. Changes between time-points were analyzed. Bimaxillary surgery was virtually planned in all patients using the Barcelona line protocol. The results showed a mean decrease in cheek angle of 5 ± 5° (P < 0.001). This decrease was reflected in a more anterior-projected cheek and was related to forward movement of the upper and lower incisors (x-axis) (r = -0.469, P = 0.014 and r = -0.440, P = 0.021, respectively). There was 3D stability of the hard and soft tissue changes at the 1-year postoperative follow-up. The results indicate that bimaxillary surgery performed following the Barcelona line as a planning reference could improve midfacial soft tissue support by means of a more anterior-projected cheek.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of sticky bone in guided bone regeneration in the aesthetic area of the anterior teeth: a retrospective study. 前牙美学区域粘骨引导骨再生的评估：一项回顾性研究。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-10 DOI: 10.1016/j.ijom.2025.01.001

X Li, X Li, H Huang

{"title":"Evaluation of sticky bone in guided bone regeneration in the aesthetic area of the anterior teeth: a retrospective study.","authors":"X Li, X Li, H Huang","doi":"10.1016/j.ijom.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.001","url":null,"abstract":"The retrospective study aimed to compare the space-maintaining effects of sticky bone (bone graft matrix enriched with injectable platelet-rich fibrin) and titanium mesh for bone augmentation in the aesthetic zone. Patients who underwent single implant placement and had type 2/4 alveolar bone defects (buccal bone wall loss is >50% of the expected implant length) were screened for inclusion in this study. The labial bone plate width was measured at 1, 3, and 5 mm below the apical implant platform on cone beam computed tomography images taken immediately and 6 months after surgery. Mimics and 3-matic software were used to measure the volume changes in the labial bone at 6 months post-surgery. Forty patients were included. There was no significant difference in the change in labial bone width between the groups at 1 mm (P = 0.22), 3 mm (P = 0.71), or 5 mm (P = 0.53). There was no significant difference in the change in labial bone volume (P = 0.70) or aesthetic scores (P = 0.27) between the groups. Sticky bone showed comparable space-maintaining effects as titanium mesh in bone augmentation for single-tooth implantation in type 2/4 bone defects in the anterior maxillary aesthetic area.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the stability of immediate dental implant placement in fresh molar extraction sockets in the maxilla and mandible: a controlled, prospective, non-randomized clinical trial. 上颌和下颌骨新鲜磨牙拔牙槽即刻种植体稳定性的比较：一项对照、前瞻性、非随机临床试验。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-09 DOI: 10.1016/j.ijom.2024.12.011

P Witoonkitvanich, P Amornsettachai, W Panyayong, D Rokaya, N Vongsirichat, S Suphangul

{"title":"Comparison of the stability of immediate dental implant placement in fresh molar extraction sockets in the maxilla and mandible: a controlled, prospective, non-randomized clinical trial.","authors":"P Witoonkitvanich, P Amornsettachai, W Panyayong, D Rokaya, N Vongsirichat, S Suphangul","doi":"10.1016/j.ijom.2024.12.011","DOIUrl":"https://doi.org/10.1016/j.ijom.2024.12.011","url":null,"abstract":"The aim of this study was to assess the stability of immediate dental implants in fresh molar extraction sockets and to compare those placed in the maxilla and mandible. This was a controlled, prospective, non-randomized clinical trial; the maxilla was the test group and the mandible was the control group. Thirty patients with an unrestorable molar tooth who needed immediate implant placement were included. The implant surgery was performed using a surgical stent and a guided surgery kit. After placement of the implant, the implant stability quotient (ISQ) was measured. A titanium customized healing abutment was inserted, and further ISQ values were obtained during 24 weeks of follow-up. The mean primary stability after immediate implant placement was >70 (73.98 ± 5.40 in the maxilla and 73.59 ± 6.74 in the mandible; P = 0.864). In the maxilla, stability was reduced at 2 weeks and 4 weeks and then increased gradually. In conclusion, immediate implant placement in the molar region with computer-guided surgery resulted in excellent implant stability. Higher mean ISQ values were obtained for the implants in the mandibular molar region when compared to the maxillary molar region (significant at 24 weeks, P = 0.018).","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of mandibular setback surgery on the upper airway and sleep quality in skeletal Class III patients and comparison with control subjects: a pilot study. 下颌退行手术对骨骼III类患者上呼吸道和睡眠质量的影响，并与对照组比较：一项初步研究。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-08 DOI: 10.1016/j.ijom.2024.12.010

S Kraivijitkul, S Rochanavibhata, C Changsiripun, P Sinpitaksakul, N Chirakalwasan, W Kongsong

{"title":"The effects of mandibular setback surgery on the upper airway and sleep quality in skeletal Class III patients and comparison with control subjects: a pilot study.","authors":"S Kraivijitkul, S Rochanavibhata, C Changsiripun, P Sinpitaksakul, N Chirakalwasan, W Kongsong","doi":"10.1016/j.ijom.2024.12.010","DOIUrl":"https://doi.org/10.1016/j.ijom.2024.12.010","url":null,"abstract":"The aim of this study was to determine the effects of mandibular setback surgery exceeding 5 mm on upper airway and sleep quality in skeletal Class III patients, with comparisons to Class I controls. Sixteen individuals per group were selected based on their ANB angle and surgical need. 2D and 3D airway analyses were conducted. Sleep quality was assessed using the Epworth Sleepiness Scale, the STOP-Bang questionnaire, and a sleep study. Following surgery, all of the skeletal Class III malocclusion patients transitioned to a Class I relationship. This transformation was accompanied by a significant reduction in pharyngeal airway space, minimum cross-sectional area (minCSA), and airway volume. Additionally, the mandibular plane to hyoid distance and airway length increased, and the total apnea-hypopnea index (AHI), obstructive AHI, and snoring levels were elevated. Compared to the control group, significant narrowing of the minCSA and reduction in airway volume, especially in the lower segment, were observed. However, no significant change in sleep quality was noted. In conclusion, the altered upper airway anatomy after mandibular setback surgery exceeding 5 mm in skeletal Class III patients was associated with an increase in AHI, but overall sleep quality was not altered compared to Class I subjects.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the comment on "Prevalence and risk factors of suicidal ideation in oral cancer: a systematic review and meta-analysis". 对“口腔癌中自杀意念的患病率和危险因素：系统回顾和荟萃分析”评论的回应。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-03 DOI: 10.1016/j.ijom.2024.12.008

S M Gondivkar, G S Sarode, A Warhekar, M Yuwanati, R Ingole, A R Gadbail, S C Sarode, P Motghare

引用次数: 0

Comment on "Prevalence and risk factors of suicidal ideation in oral cancer: a systematic review and meta-analysis". 《口腔癌患者自杀意念的患病率及危险因素：一项系统综述和荟萃分析》

International journal of oral and maxillofacial surgery Pub Date : 2025-01-03 DOI: 10.1016/j.ijom.2024.12.007

R Mehta, A K Balaraman, M Shabil, S Sah

引用次数: 0

Securing the Puncture Depth via an Endodontic Stopper in Arthrocentesis of the Temporomandibular Joint: A Technical Note. 在颞下颌关节置换术中使用牙髓塞固定穿刺深度：技术要点。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-02 DOI: 10.1016/j.ijom.2024.12.009

A Gülses, C Flörke, J-T Weitkamp, J Wiltfang

引用次数: 0