B Öhrnell Malekzadeh, L-O Öhrnell, G Widmark, R M Beigi, C-J Ivanoff
{"title":"Effects of platelet-rich fibrin on outcomes following mandibular third molar removal: a randomized controlled clinical trial.","authors":"B Öhrnell Malekzadeh, L-O Öhrnell, G Widmark, R M Beigi, C-J Ivanoff","doi":"10.1016/j.ijom.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.06.007","url":null,"abstract":"<p><p>Surgical removal of mandibular third molars is a routine procedure in oral and maxillofacial surgery, often followed by pain, swelling, trismus, and alveolar osteitis (AO), affecting patient comfort and daily function. Platelet-rich fibrin (PRF) is an autologous biomaterial that promotes healing through the gradual release of cytokines and growth factors. This prospective, randomized, controlled, and patient-blinded study investigated whether PRF applied to the extraction socket reduces postoperative symptoms and complications. Ninety patients scheduled for mandibular third molar removal were randomized to receive PRF or no adjunct treatment prior to wound closure. Seventy-five patients completed follow-up and were included in the analysis. Postoperative outcomes including AO, infection, pain, trismus, analgesic use, and sick leave were recorded over 10 days. The incidence of AO was lower in the PRF group (3.0%) compared to the control group (11.9%), although the difference was not statistically significant. PRF treatment significantly reduced postoperative pain during the first six days. These findings suggest that while PRF may not significantly reduce AO incidence, it can contribute to improved patient comfort and recovery by decreasing early postoperative pain.</p>","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R B Cardoso, C Ruppel, V L Pereira, F A Dos Santos, M C Bortoluzzi
{"title":"Effect of paracetamol-codeine compared to placebo on surgical discomfort and post-traumatic stress disorder symptoms following mandibular third molar removal: a prospective randomized clinical trial.","authors":"R B Cardoso, C Ruppel, V L Pereira, F A Dos Santos, M C Bortoluzzi","doi":"10.1016/j.ijom.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.05.010","url":null,"abstract":"<p><p>This study investigated the impact of a single, pre-emptive 500 mg paracetamol plus 7.5 mg codeine phosphate dose on surgical discomfort, anxiety, post-traumatic stress disorder (PTSD) symptoms, and pain during mandibular third molar extraction. Patients were randomized to receive either the drug combination or a placebo.Preoperative anxiety was assessed using the State-Trait Anxiety Inventory (STAI), Dental Anxiety Scale (DAS), and anxiety visual analogue scale (Anxiety-VAS). Post-surgery, discomfort was measured with the Self-Perception Questionnaire of Dentoalveolar Oral Surgery (QCirDental), while pain and anxiety were assessed using VAS scales. Patients also maintained a postoperative pain diary. On day 7, the Impact of Event Scale-Revised (IES-R) evaluated surgery-related PTSD symptoms.Sixty patients completed the study (30 per group), with similar demographics and surgical characteristics. Results indicated no significant difference in anxiety (STAI, DAS, Anxiety-VAS) between groups. The pre-emptive medication was similarly effective to placebo for managing anxiety, intraoperative discomfort, and postoperative pain.A stressful surgical event was observed in 13.3% of patients, leading to clinical concern or probable oral surgery-related PTSD. However, the paracetamol-codeine group did not show improved overall IES-R scores. Ultimately, a single pre-emptive dose of 500 mg paracetamol plus 7.5 mg codeine phosphate offered no additional benefits in mandibular third molar surgery.</p>","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T Singkhorn, P Pripatnanont, T Nuntanaranont, D Supakanjanakanti, W Ritthagol
{"title":"Response to the comment on \"Influence of a resorbable collagen membrane for alveolar bone graft on clinical outcomes and ridge volume stability in cleft alveolus\".","authors":"T Singkhorn, P Pripatnanont, T Nuntanaranont, D Supakanjanakanti, W Ritthagol","doi":"10.1016/j.ijom.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.06.006","url":null,"abstract":"","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B Gareb, A Vissink, H Terheyden, H J A Meijer, G M Raghoebar
{"title":"Response to the comment on \"Outcomes of implants placed in sites of previously failed implants: a systematic review and meta-analysis\".","authors":"B Gareb, A Vissink, H Terheyden, H J A Meijer, G M Raghoebar","doi":"10.1016/j.ijom.2025.06.001","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.06.001","url":null,"abstract":"","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Influence of a resorbable collagen membrane for alveolar bone graft on clinical outcomes and ridge volume stability in cleft alveolus\".","authors":"A Akbari, F Bastami","doi":"10.1016/j.ijom.2025.06.004","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.06.004","url":null,"abstract":"","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R S A Ten Brink, B J Merema, M E den Otter, M L Jensma, M J H Witjes, J Kraeima
{"title":"Automatic MRI segmentation of masticatory muscles using deep learning enables large-scale muscle parameter analysis.","authors":"R S A Ten Brink, B J Merema, M E den Otter, M L Jensma, M J H Witjes, J Kraeima","doi":"10.1016/j.ijom.2025.05.008","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.05.008","url":null,"abstract":"<p><p>Mandibular reconstruction to restore mandibular continuity often relies on patient-specific implants and virtual surgical planning, but current implant designs rarely consider individual biomechanical demands, which are critical for preventing complications such as stress shielding, screw loosening, and implant failure. The inclusion of patient-specific masticatory muscle parameters such as cross-sectional area, vectors, and volume could improve implant success, but manual segmentation of these parameters is time-consuming, limiting large-scale analyses. In this study, a deep learning model was trained for automatic segmentation of eight masticatory muscles on MRI images. Forty T1-weighted MRI scans were segmented manually or via pseudo-labelling for training. Training employed 5-fold cross-validation over 1000 epochs per fold and testing was done on 10 manually segmented scans. The model achieved a mean Dice similarity coefficient (DSC) of 0.88, intersection over union (IoU) of 0.79, precision of 0.87, and recall of 0.89, demonstrating high segmentation accuracy. These results indicate the feasibility of large-scale, reproducible analyses of muscle volumes, directions, and estimated forces. By integrating these parameters into implant design and surgical planning, this method offers a step forward in developing personalized surgical strategies that could improve postoperative outcomes in mandibular reconstruction. This brings the field closer to truly individualized patient care.</p>","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Outcomes of implants placed in sites of previously failed implants: a systematic review and meta-analysis\".","authors":"S Kumar, R Mehta, R Sah","doi":"10.1016/j.ijom.2025.06.002","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.06.002","url":null,"abstract":"","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Sayed, S Salam, M Lubbad, A I Al-Jalahma, M A AlMuharraqi, G Sivaramakrishnan
{"title":"Craniomaxillofacial osteolipoma: a rare case and review of the literature.","authors":"A Sayed, S Salam, M Lubbad, A I Al-Jalahma, M A AlMuharraqi, G Sivaramakrishnan","doi":"10.1016/j.ijom.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.05.009","url":null,"abstract":"<p><p>Osteolipoma is a rare variant of lipoma, accounting for 0.3% of all lipomas, and comprises mature adipose and osseous tissues. It is rare in the head and neck region, with only 54 documented cases to date. This report presents the case of a 14-year-old male patient with an unusually large osteolipoma in the craniomaxillofacial region, highlighting its clinical, radiological, and histological features, while emphasizing diagnostic challenges and the importance of imaging for the differential diagnosis. The rarity of osteolipomas highlights the importance of documenting unique cases, aiding diagnosis and management, with long-term follow-up essential for monitoring recurrence.</p>","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T Würsching, A Kesztyűs, L Pottel, G Swennen, K Nagy
{"title":"Comparison of two methods for segmentation of the nasoalveolar defect and design of a three-dimensional surgical template in patients with cleft lip and palate: a retrospective study.","authors":"T Würsching, A Kesztyűs, L Pottel, G Swennen, K Nagy","doi":"10.1016/j.ijom.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.05.006","url":null,"abstract":"<p><p>Alveolar bone grafting is an essential step in the treatment of cleft lip and palate. A method for designing a surgical template for the ideal graft volume and shape has been published previously. The aim of this study was to compare different software for the segmentation of the graft and design of the surgical template. Ten patients with unilateral cleft lip and palate were included. iPlan ENT was used for the first workflow and 3D Slicer and Blender for the second workflow. Every plan was done by two investigators. The planning time was compared between the two workflows and the two investigators. The results of the segmentation were compared by volumetric analysis. Planning with iPlan was significantly faster than 3D Slicer/Blender (P = 0.037 and P = 0.005, first and second planning by investigator 1; P = 0.017 for investigator 2). The median planning time for the experienced investigator was 297 s with iPlan and 390 s with 3D Slicer/Blender. The mean difference in graft volume was not significant (0.042 cm<sup>3</sup>). The mean ± standard deviation Hausdorff distance was 1.52 ± 0.57 mm and Dice similarity coefficient was 0.91 ± 0.02. These results show that both workflows are viable.</p>","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B Kampeera, N Sriyaranya, Y Aschaitrakool, W Powcharoen
{"title":"Development and validation of a predictive scoring system for excessive intraoperative blood loss in orthognathic surgery.","authors":"B Kampeera, N Sriyaranya, Y Aschaitrakool, W Powcharoen","doi":"10.1016/j.ijom.2025.05.007","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.05.007","url":null,"abstract":"<p><p>Risk stratification for excessive bleeding prior to orthognathic surgery is necessary for optimizing patient safety and enhancing postoperative recovery. The aim of this study was to develop and validate a simplified scoring system for predicting excessive intraoperative blood loss (IBL) during orthognathic surgery. This retrospective cohort study included 361 patients who underwent orthognathic surgery. Factors related to excessive IBL were analysed. The candidate predictors for excessive IBL were determined by logistic regression analysis. The performance of the model was assessed through its discrimination ability and a calibration plot. Internal validation was done by bootstrap resampling technique. The regression coefficients were transformed into a scoring system. Excessive IBL occurred in 32.7% of patients (118/361). The predictive scoring system included three predictors: body mass index (score 0, 1.5, 2: overweight, normal weight, underweight), systolic blood pressure (score 0, 1: <130, ≥130 mmHg), and operative time (score 0, 2.5: ≤4, >4 h). The area under the receiver operating characteristic curve (AUROC) for discrimination ability was 0.828 (internal validation: C-statistic 0.812). Risk was then classified as low (0-2.5 points) or high (3-5.5 points). The prognostic ability of this simplified scoring system was found to be clinically acceptable for predicting excessive IBL during orthognathic surgery.</p>","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}