International journal of oral and maxillofacial surgery最新文献_第2页

Complications of self-drilling intermaxillary fixation screws with a focus on dental root damage. 自钻孔上颌间固定螺钉治疗牙根损伤的并发症。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-10-13 DOI: 10.1016/j.ijom.2026.09.021

L H van der Hoek, A J W P Rosenberg, E M Van Cann

{"title":"Complications of self-drilling intermaxillary fixation screws with a focus on dental root damage.","authors":"L H van der Hoek, A J W P Rosenberg, E M Van Cann","doi":"10.1016/j.ijom.2026.09.021","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.09.021","url":null,"abstract":"Intermaxillary fixation is often used in oral and maxillofacial surgery for temporary jaw stabilization. Self-drilling intermaxillary fixation screws are easy to use but can cause dental damage. This retrospective study was performed to examine the complications associated with self-drilling screws, with a focus on dental root damage. Overall, 274 screws were placed in 43 patients between 2010 and 2023 at University Medical Center Utrecht. Patients with missing postoperative imaging or screws placed in edentulous areas were excluded, leaving 162 screws in 28 patients for evaluation. Complications were documented from the patient records and postoperative imaging (panoramic radiographs and/or (cone-beam) computed tomography scans). Dental roots adjacent to 24 screws (14.8%) showed damage on imaging. Logistic regression analysis showed a significantly lower risk of dental root damage with larger interdental distances (OR (per millimetre increase) 0.379, 95% confidence interval 0.210-0.683, P = 0.001). A higher incidence of dental root damage was observed in the posterior region of the jaw; however, no significant association was found between screw location and root damage. Other complications among the 274 screws placed were irritated mucosa (associated with 6.2% of fixation screws), screw loosening (associated with 5.8%), screw overgrowth by oral mucosa (associated with 5.1%), and screw fracture (associated with 0.7%). The placement of self-drilling screws in regions with wider interdental distances is recommended to avoid dental root damage. Studies with larger sample sizes are required to clarify whether screw location independently influences the risk of root injury.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An unusual Case of p63/p40 Negative Myoepithelial cell-Rich Parotid Pleomorphic Adenoma. p63/p40阴性肌上皮细胞丰富的腮腺多形性腺瘤1例。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-10-12 DOI: 10.1016/j.ijom.2026.09.023

R Abbas, J Augustine, P Kumar, S Mohanty, A B Urs

{"title":"An unusual Case of p63/p40 Negative Myoepithelial cell-Rich Parotid Pleomorphic Adenoma.","authors":"R Abbas, J Augustine, P Kumar, S Mohanty, A B Urs","doi":"10.1016/j.ijom.2026.09.023","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.09.023","url":null,"abstract":"Pleomorphic adenoma is the most common benign salivary gland neoplasm; however, myoepithelial-rich variants with unusual immunophenotypes are rare and pose diagnostic challenges. We report a myoepithelial-rich pleomorphic adenoma of the parotid gland in a 23-year-old male presenting with a slowly enlarging, painless infraauricular swelling. Grossly, the lesion was well-circumscribed and encapsulated. Histopathology revealed predominantly spindle, oval, and plasmacytoid myoepithelial cells embedded in densely hyalinized fibromyxoid stroma, with sparse ductal structures. The paucity of ducts and prominent myoepithelial proliferation closely mimicked myoepithelioma. Immunohistochemically, tumor cells showed diffuse expression of S100, pan-cytokeratin, and high-molecular-weight cytokeratin, supporting epithelial and myoepithelial differentiation. EMA and CD117 selectively highlighted the sparse ductal structures, providing a crucial diagnostic clue. Notably, the tumor was completely negative for p40, p63, and smooth muscle actin, representing an unusual immunophenotype for pleomorphic adenoma. Despite the absence of conventional myoepithelial markers, integration of the subtle residual ductal morphology and complementary immunoprofile established the diagnosis of myoepithelial-rich pleomorphic adenoma, excluding myoepithelioma and other salivary gland neoplasms. The patient recovered uneventfully after surgery and remained recurrence-free at six months. This case expands the immunohistochemical spectrum of pleomorphic adenoma and highlights that the absence of p40 and p63 expression should not preclude its diagnosis. Comprehensive immunohistochemical assessment, interpreted alongside meticulous histomorphological evaluation, is essential to avoid diagnostic pitfalls in these uncommon tumors.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of peri-implantitis of extraoral craniofacial endosseous implants: a scoping review. 口腔外颅面内种植体种植周炎的治疗：范围回顾。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-10-12 DOI: 10.1016/j.ijom.2026.09.024

M Timme, M C Menne, T Otto, J-D Raguse

{"title":"Treatment of peri-implantitis of extraoral craniofacial endosseous implants: a scoping review.","authors":"M Timme, M C Menne, T Otto, J-D Raguse","doi":"10.1016/j.ijom.2026.09.024","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.09.024","url":null,"abstract":"This scoping review was performed to synthesize the currently available evidence on the management of peri-implantitis affecting extraoral craniofacial endosseous implants, a condition that presents unique anatomical and microbiological challenges. Although a recently proposed treatment algorithm has gained attention in the literature, it is based on low-level evidence and is overly complex for routine clinical use, serving primarily as a conceptual or research-oriented framework. Pragmatic, evidence-based guidelines tailored to extraoral craniofacial endosseous implants remain lacking. JBI and PRISMA-ScR standards were followed to conduct a structured search, complemented by handsearching and reference screening. Eight studies met the inclusion criteria; only one was prospective. No added benefit was found for local antibiotics compared with mechanical cleaning using hydrogen peroxide. Lower-level evidence consistently emphasized meticulous hygiene instruction, mechanical debridement, and adjunctive topical antiseptics such as chlorhexidine or hydrogen peroxide. Systemic antibiotics guided by microbiological testing were recommended for advanced or refractory cases, whereas implant mobility uniformly indicated explantation. Increased peri-implant skin thickness was associated with poorer outcomes, suggesting a potential role for soft tissue thinning when surgically feasible. Overall, current treatment algorithms and available evidence are of limited practical value. High-quality, comparative research is urgently needed to establish evidence-based and clinically feasible treatment pathways as they have long existed in dental implantology. Future work should further define the indications, efficacy, and optimal use of specific agents to support the development of robust, practice-oriented therapeutic recommendations.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Volumetric changes in articulating interpositional spacers for two-stage temporomandibular joint arthroplasty. A pilot study. 两期颞下颌关节置换术中关节间置间隔器的体积变化。一项初步研究。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-10-10 DOI: 10.1016/j.ijom.2026.10.001

M E Mahmoud, W J Fillmore

{"title":"Volumetric changes in articulating interpositional spacers for two-stage temporomandibular joint arthroplasty. A pilot study.","authors":"M E Mahmoud, W J Fillmore","doi":"10.1016/j.ijom.2026.10.001","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.10.001","url":null,"abstract":"Two-stage temporomandibular joint (TMJ) arthroplasty may involve the placement of a spacer until a final prosthesis is placed. In cases where a patient is not immobilized via intermaxillary fixation (IMF), the spacer is considered to be articulating, and the patient can open their mouth and function more normally during this interval. This study was designed to retrospectively assess the volumetric changes of the spacer within the temporomandibular joint following the use of an articulating bone cement spacer in a two-stage reconstruction. Fourteen patients (thirteen females, one male with mean ± SD age of 58.1 ± 13.0 years underwent two-stage TMJ reconstruction with an articulating spacer. The mean duration of the spacer retention was 142.1 ± 58.4 days. The median volume change of the temporomandibular joint spacer was quantified. Longer retention of the spacer was significantly associated with greater volume change (P = 0.011). There was no impact on prosthesis fit or occlusion at the time of surgery, and prosthesis outcomes were good. This study indicates that the duration of retention of the articulating bone cement spacer in the TMJ influences the amount of spacer volumetric changes, although the amount of change does not appear to be clinically significant.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between maxillary movement and changes in nasolabial and nasofacial angles after Le Fort I osteotomy. Le Fort I型截骨术后上颌运动与鼻唇角及鼻面角变化的关系。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-10-06 DOI: 10.1016/j.ijom.2026.09.015

S Koshinuma, Y Asada, Y Takeda, R Hirai, T Murai, K Takaoka

{"title":"Correlation between maxillary movement and changes in nasolabial and nasofacial angles after Le Fort I osteotomy.","authors":"S Koshinuma, Y Asada, Y Takeda, R Hirai, T Murai, K Takaoka","doi":"10.1016/j.ijom.2026.09.015","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.09.015","url":null,"abstract":"Nasal aesthetic changes are a key concern in orthognathic surgery. This retrospective cohort study investigated whether the direction and magnitude of maxillary movement independently affect postoperative nasolabial angle (NLA) and nasofacial angle (NFA) following Le Fort I osteotomy in bimaxillary surgery. Forty-four patients (10 men, 34 women; median age 24 years) treated at a single institution were analyzed using standardized lateral cephalograms obtained preoperatively and at 1 week and 12 months postoperatively. Horizontal (anteroposterior) and vertical (superoinferior) maxillary displacements were derived from three-dimensional surgical planning and validated by cephalometric superimposition. Changes in NLA and NFA were assessed using Pearson correlation and multiple linear regression analyses, including change in sella-nasion-B point (SNB) angle as a confounder. Horizontal advancement was significantly correlated with NLA (r = 0.32, P = 0.034) and NFA (r = 0.68, P < 0.001), whereas vertical movement showed no significant correlation with NLA and a modest negative correlation with NFA (r = -0.43, P = 0.004). Multiple regression analysis showed that horizontal advancement independently predicted increased NFA (unstandardized coefficient = 0.80, P < 0.001), whereas the NLA model was not statistically significant (R² = 0.13, P = 0.114). Horizontal maxillary advancement demonstrated a relatively predictable relationship with NFA, whereas NLA changes were more variable and less reliably predicted by skeletal movement alone. NFA may therefore be a more robust parameter for preoperative prediction, patient counseling, and refinement of digital surgical simulations.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early findings of morphological changes in the temporomandibular joint after orthognathic surgery in mandibular prognathism with facial asymmetry. 面部不对称的下颌前突正颌手术后颞下颌关节形态学改变的早期发现。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-09-26 DOI: 10.1016/j.ijom.2026.09.009

T Yamada, J Nihara, H Nishiyama, T Kobayashi, K Yamada, I Saito

{"title":"Early findings of morphological changes in the temporomandibular joint after orthognathic surgery in mandibular prognathism with facial asymmetry.","authors":"T Yamada, J Nihara, H Nishiyama, T Kobayashi, K Yamada, I Saito","doi":"10.1016/j.ijom.2026.09.009","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.09.009","url":null,"abstract":"This study was performed to investigate early morphological changes in the temporomandibular joint (TMJ), after patients with mandibular prognathism with facial asymmetry (MPA) received orthognathic surgery. The morphological changes in the TMJ were analyzed on computed tomography multi-sectional reconstructed images first taken before preoperative orthodontic treatment and then again 6 months after orthognathic surgery, in 39 patients with MPA. A combination of Le Fort I osteotomy and bilateral sagittal split osteotomy (BSSO) was performed in 22 patients and BSSO alone was performed in 17 patients. Compared to the non-deviated side, both before preoperative orthodontic treatment and 6 months after surgery, the posterior slope of the articular eminence was significantly steeper (P < 0.001, P < 0.001, respectively), and the mandibular fossa significantly deeper on the deviated side (P < 0.001, P = 0.002, respectively). However, 6 months after surgery, on the non-deviated side the posterior slope of the articular eminence had become significantly steeper (P = 0.005), and the mandibular fossa significantly deeper (P = 0.009), compared to their preoperative morphologies, suggesting a gradual improvement in the morphological asymmetry of the TMJ. These early morphological changes in the TMJ on the non-deviated side at 6 months postoperatively may be due to improvements to the asymmetric loading in the temporomandibular joints, associated with the surgical improvement of facial asymmetry.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes for recipient vessel selection in head and neck free flap reconstruction: a retrospective cohort study. 头颈部游离皮瓣重建中受体血管选择的结果：一项回顾性队列研究。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-09-24 DOI: 10.1016/j.ijom.2026.09.013

J Mohr, L Bergner, K Pippich, M Nieberler, J Ketschau, H Singer, A Grabenhorst, N Krautkremer, W Klaus-Dietrich, L M Ritschl

{"title":"Outcomes for recipient vessel selection in head and neck free flap reconstruction: a retrospective cohort study.","authors":"J Mohr, L Bergner, K Pippich, M Nieberler, J Ketschau, H Singer, A Grabenhorst, N Krautkremer, W Klaus-Dietrich, L M Ritschl","doi":"10.1016/j.ijom.2026.09.013","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.09.013","url":null,"abstract":"Microvascular free flap reconstruction is essential in head and neck reconstruction. Cervical recipient vessels are traditionally preferred, whereas temporal recipient vessels are increasingly used in selected cases. This study aimed to compare outcomes of temporally versus cervically anastomosed free flaps. A retrospective cohort study including 158 free flap reconstructions was conducted at a single center. Seventy-nine flaps were anastomosed to temporal recipient vessels and compared with a cohort of cervically anastomosed flaps during the same period. Baseline characteristics, perioperative variables, and postoperative outcomes were assessed. Primary outcomes were vascular revision and flap survival. Secondary outcomes included partial and total flap loss. Multivariable analyses accounted for anatomical defect localization and surgical complexity. Baseline characteristics were comparable between groups. Vascular revision of the microvascular anastomosis occurred in five out of 79 flaps (6%) in both cohorts (odds ratio 1.00, 95% confidence interval 0.28-3.60; P = 1.00). Total flap loss occurred in four out of 79 cervical cases (5%) and one out of 79 temporal cases (1%) (0.24, 0.03-2.20; P = 0.21). Operative time was shorter in the temporal group (P < 0.001), while ischemia time was comparable (P = 0.95). Temporally anastomosed patients had higher American Society of Anesthesiologists scores (P = 0.009), without increased medical complications or resource utilization. Temporal recipient vessels represent a safe and effective alternative to cervical vessels in head and neck free flap reconstruction. After accounting for anatomical defect localization and surgical complexity, recipient vessel location was not associated with differences in vascular revision or flap survival.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for dental implant failure in vascularized bone flaps: a decade-long cohort study. 血管化骨瓣种植体失败的危险因素：一项长达十年的队列研究。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-09-24 DOI: 10.1016/j.ijom.2026.09.007

A R Tofighbakhsh, G W Jenkins, C C Lee, I Ellabban, D Dyalram, J E Lubek

{"title":"Risk factors for dental implant failure in vascularized bone flaps: a decade-long cohort study.","authors":"A R Tofighbakhsh, G W Jenkins, C C Lee, I Ellabban, D Dyalram, J E Lubek","doi":"10.1016/j.ijom.2026.09.007","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.09.007","url":null,"abstract":"This study aims to evaluate the survival of dental implants placed exclusively within vascularized osseous free flaps for oral cavity reconstruction and to identify key risk factors for implant failure. A retrospective cohort study was conducted on 105 patients who received 358 dental implants within fibula, scapula, or deep circumflex iliac artery free flaps at a single institution over a 10-year period. The primary outcome was implant failure, defined as removal for any reason. Statistical analysis employed multivariate mixed-effects Cox regression models to account for patient-level clustering and confounding variables, including adjuvant radiotherapy, jaw location, donor site, and smoking status. Kaplan-Meier analysis demonstrated cumulative implant survival rates of 93.4% at 1 year, 89.2% at 2 years, and 83.9% at 3 years following implant placement. Implant survival remained relatively stable thereafter. Multivariate analysis identified two significant independent risk factors for implant failure: exposure to adjuvant radiotherapy (hazard ratio (HR): 3.46, P = 0.009) and placement in a reconstructed maxilla compared to the mandible (HR: 3.00, P = 0.040). The most common causes of failure were infection/peri-implantitis (68.5%) and osteoradionecrosis. Donor site type and smoking status were not significantly associated with failure in the adjusted model. Dental implants placed in vascularized bone flaps provide a viable rehabilitation method, though failure rates are higher. Adjuvant radiotherapy and maxillary location are the most critical risk factors, increasing the hazard of failure by approximately 3.5- and 3-fold, respectively. These findings underscore the need for careful patient selection and tailored approaches in this complex population.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of mandibular reconstruction using conventional plates vs patient-specific implants. 使用常规钢板与患者特异性种植体重建下颌骨的结果。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-09-24 DOI: 10.1016/j.ijom.2026.09.010

Y Matsuzaki, Y Watabe, S Shigematsu, A Watanabe

{"title":"Outcomes of mandibular reconstruction using conventional plates vs patient-specific implants.","authors":"Y Matsuzaki, Y Watabe, S Shigematsu, A Watanabe","doi":"10.1016/j.ijom.2026.09.010","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.09.010","url":null,"abstract":"Recent progress using computer-aided design and computer-aided manufacturing technology has enabled the fabrication of surgical guides and reconstruction plates tailored to individual patients. These patient-specific implants (PSI), which are now being widely used for mandibular reconstruction surgery for oral cancer, have improved the efficiency of surgery and have allowed more precise execution of the preoperative plan. The present study compared the efficacy of PSI with conventional reconstruction plates (CR) requiring bending for mandibular reconstruction following segmental and hemimandibular resection in patients with an oral malignancy who underwent free-flap reconstruction including a reconstruction or bridging plate without bone. Thirty-nine patients from the previous 8 years were analyzed, including 21 with PSI-based reconstructions and 18 with CR. The median follow-up period was 1322 days (range 91-3225). Soft-tissue reconstruction was performed using an anterolateral thigh flap in all cases. The PSI group demonstrated a significantly shorter operative time (P = 0.0002), reduced intraoperative blood loss (P = 0.0039), and no instances of plate-related infection compared to three cases in the CR group. These findings highlighted the advantages of PSI for improving surgical efficiency and minimizing the burden on the patient, particularly in patients with free-flap mandibular reconstructions without microvascular bone flaps, such as a fibular or iliac crest flap.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short- and long-term outcomes of photodynamic therapy in oral potentially malignant disorders. 光动力治疗口腔潜在恶性疾病的短期和长期结果。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-09-22 DOI: 10.1016/j.ijom.2026.09.005

X-Y Liu, Q-Y Guo, Q Wang, Y-T Wang, Y Han, H-W Liu

{"title":"Short- and long-term outcomes of photodynamic therapy in oral potentially malignant disorders.","authors":"X-Y Liu, Q-Y Guo, Q Wang, Y-T Wang, Y Han, H-W Liu","doi":"10.1016/j.ijom.2026.09.005","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.09.005","url":null,"abstract":"This study evaluated the efficacy of 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) in 94 patients with oral potentially malignant disorders (OPMDs). Patients were treated with 20% 5-ALA and 635 nm laser light at 100 J/cm2 every 1-3 weeks, followed by at least 1 year of follow-up. Among the 94 patients, 36.2% achieved a complete response, with an overall response rate of 92.6%. Factors predicting better short-term efficacy included good oral hygiene (P = 0.042), no baseline pain (P = 0.025), single lesions (P = 0.025), lesion size <2 cm2 (P = 0.002), and the use of topical incubation (P = 0.004), particularly for ≥2.5 h (P = 0.002). With a median follow-up of 38 months, the cumulative recurrence rates were 33.0% at 1 year, 42.6% at 2 years, and the cumulative malignant transformation (MT) rates were 1.1% at 1 year, 10.6% at 2 years, and 25.5% at 5 years. Cox regression analysis identified female gender as an independent risk factor for recurrence. Hyperglycemia and lack of initial clinical response were independent predictors for MT. After 1:1 propensity score matching based on gender, age, and oral epithelial dysplasia grade, 84 pairs of patients were included in the PDT group and the control group. Kaplan-Meier survival analysis revealed that the matched control group showed faster MT (P = 0.041), especially among patients with lesions in high-risk areas (P = 0.001). The study indicates that 5-ALA-PDT is an effective treatment for OPMDs and may protect against malignant progression.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0