{"title":"Low-dose tranexamic acid in orthognathic surgery: two-dose protocol-a double-blind randomized controlled trial on oedema, bleeding, and visibility of the surgical field.","authors":"G Kaşarcıoğlu, T Pergel, E F Akkoyun, D Dolanmaz","doi":"10.1016/j.ijom.2025.04.010","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.04.010","url":null,"abstract":"<p><p>The aim of this double-blind randomized controlled trial was to evaluate the effects of a two-dose tranexamic acid (TXA) protocol on oedema, bleeding, and surgical field visibility during orthognathic surgery. 72 patients participated and were assigned to three groups: the TXA250 group received a single intravenous dose of 250 mg TXA prior to incision; the TXA500 group received 250 mg TXA before incision and 250 mg after the first jaw surgery was completed; the control group received no TXA. Oedema was measured preoperatively and on postoperative days 1, 3, and 7. Sixty-four patients completed the study. Bleeding was significantly higher and Fromme scale scores for surgical field visibility were significantly lower in the control group compared to the TXA groups (all P < 0.001). The TXA500 group demonstrated significantly reduced oedema compared to the control group (day 3: P = 0.037, day 7: P = 0.002), while the comparison of the TXA250 and control groups showed no significant difference. However, there was no significant difference in oedema between the two TXA groups. Hence, no firm conclusions can be drawn about the superiority of two-dose TXA over the single dose; this needs further investigation in a future study.</p>","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A semi-automated design workflow for patient-specific implants in orthognathic surgery using generative design.","authors":"M Cheng, A Nayak, Y Y Leung","doi":"10.1016/j.ijom.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.03.011","url":null,"abstract":"<p><p>Patient-specific implants (PSIs) have demonstrated improved outcomes and have reduced the complexity of surgery in orthognathic surgery. However, the design process for PSIs is time-consuming and complicated, leading to high costs that hinder its widespread adoption. The aim of this study was to develop a novel workflow for designing PSIs using generative design (GD) techniques to streamline the process. The proposed workflow was implemented using GD-embedded software, Fusion (Autodesk Inc.), and tested by designing PSIs for one Le Fort I osteotomy case and one genioplasty case. The performance of the GD workflow was assessed through the time required for design and the basic properties of the GD PSIs. The hands-on time for the design was 94 min for the Le Fort I fixation plate and 45 min for the genioplasty plate. The maximum von Mises stress was 227.63 MPa for the Le Fort I fixation plate and 237.31 MPa for the genioplasty fixation plate. The GD-based workflow simplified and accelerated the design of PSIs for orthognathic surgery. Biomechanical analysis indicated the feasibility of generative designed patient-specific implants for clinical practice.</p>","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K Warin, W Limprasert, T Paipongna, S Chaowchuen, S Vicharueang
{"title":"Response to the comment on \"Deep convolutional neural network for automatic segmentation and classification of jaw tumors in contrast-enhanced computed tomography images\".","authors":"K Warin, W Limprasert, T Paipongna, S Chaowchuen, S Vicharueang","doi":"10.1016/j.ijom.2025.01.019","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.019","url":null,"abstract":"","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on: \"Deep convolutional neural network for automatic segmentation and classification of jaw tumors in contrast-enhanced computed tomography images\".","authors":"C M Ardila, P K Yadalam","doi":"10.1016/j.ijom.2025.01.020","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.020","url":null,"abstract":"","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S M Gondivkar, G S Sarode, A Warhekar, M Yuwanati, R Ingole, A R Gadbail, S C Sarode, P Motghare
{"title":"Response to the comment on \"Prevalence and risk factors of suicidal ideation in oral cancer: a systematic review and meta-analysis\".","authors":"S M Gondivkar, G S Sarode, A Warhekar, M Yuwanati, R Ingole, A R Gadbail, S C Sarode, P Motghare","doi":"10.1016/j.ijom.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.ijom.2024.12.008","url":null,"abstract":"","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Prevalence and risk factors of suicidal ideation in oral cancer: a systematic review and meta-analysis\".","authors":"R Mehta, A K Balaraman, M Shabil, S Sah","doi":"10.1016/j.ijom.2024.12.007","DOIUrl":"https://doi.org/10.1016/j.ijom.2024.12.007","url":null,"abstract":"","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}