International journal of oral and maxillofacial surgery最新文献_第7页

Pretreatment nutritional indices are associated with survival and T-cell exhaustion in recurrent or metastatic oral squamous cell carcinoma patients treated with immune checkpoint inhibitors: a retrospective cohort study. 治疗前营养指数与接受免疫检查点抑制剂治疗的复发性或转移性口腔鳞状细胞癌患者的生存期和T细胞衰竭有关：一项回顾性队列研究。

International journal of oral and maxillofacial surgery Pub Date : 2025-02-11 DOI: 10.1016/j.ijom.2025.01.010

T Ooyama, M Hirayama, Y Seki, A Iwamoto, R Yoshida, H Nakayama

{"title":"Pretreatment nutritional indices are associated with survival and T-cell exhaustion in recurrent or metastatic oral squamous cell carcinoma patients treated with immune checkpoint inhibitors: a retrospective cohort study.","authors":"T Ooyama, M Hirayama, Y Seki, A Iwamoto, R Yoshida, H Nakayama","doi":"10.1016/j.ijom.2025.01.010","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.010","url":null,"abstract":"Pretreatment immune dynamics and nutritional status are important predictors of survival outcomes in various malignancies. This study was performed to evaluate the relationships between survival outcomes and the pretreatment nutritional indices - Onodera's prognostic nutritional index (OPNI) and neutrophil-to-lymphocyte ratio (NLR) - in 42 patients with recurrent or metastatic oral squamous cell carcinoma (OSCC) who underwent treatment with immune checkpoint inhibitors (ICI). Additionally, the relationships between these nutritional indices and T-cell exhaustion in the peripheral blood of the patients were analysed. As a result, the Kaplan-Meier method revealed that lower OPNI was significantly associated with poorer overall survival (OS) and progression-free survival (PFS) (both P < 0.001). Likewise, the results of the multivariate analysis showed that a low OPNI was independently associated with poor 5-year OS (hazard ratio 4.36, P = 0.008) and PFS (hazard ratio 4.04, P = 0.010). Patients with a low OPNI had a significantly higher frequency of PD-1+ CD8+ T-cells than those with a high OPNI (P = 0.009). These findings demonstrate that pretreatment OPNI is a valuable independent prognostic indicator of OS and PFS in OSCC patients following treatment with ICI. The OPNI might reflect T-cell exhaustion in the peripheral blood of OSCC patients.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the comment on "Deep convolutional neural network for automatic segmentation and classification of jaw tumors in contrast-enhanced computed tomography images". 对“基于深度卷积神经网络的增强ct图像下颌肿瘤自动分割分类”评论的回应。

International journal of oral and maxillofacial surgery Pub Date : 2025-02-08 DOI: 10.1016/j.ijom.2025.01.019

K Warin, W Limprasert, T Paipongna, S Chaowchuen, S Vicharueang

引用次数: 0

Comment on: "Deep convolutional neural network for automatic segmentation and classification of jaw tumors in contrast-enhanced computed tomography images". 评论：“用于对比增强计算机断层扫描图像中下颌肿瘤自动分割和分类的深度卷积神经网络”。

International journal of oral and maxillofacial surgery Pub Date : 2025-02-07 DOI: 10.1016/j.ijom.2025.01.020

C M Ardila, P K Yadalam

引用次数: 0

Clinical validation of the virtual splint registration workflow for craniomaxillofacial surgery. 颅颌面外科虚拟夹板配准流程的临床验证。

International journal of oral and maxillofacial surgery Pub Date : 2025-02-06 DOI: 10.1016/j.ijom.2025.01.014

J F Sabelis, R Schreurs, L Dubois, A G Becking

{"title":"Clinical validation of the virtual splint registration workflow for craniomaxillofacial surgery.","authors":"J F Sabelis, R Schreurs, L Dubois, A G Becking","doi":"10.1016/j.ijom.2025.01.014","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.014","url":null,"abstract":"Accurate registration is vital to transfer the virtual surgical plan during surgery. This study's goal was to present and clinically validate a virtual splint registration workflow. Ten dentate patients requiring revision surgery were included. Specific inclusion criterion for this study was the presence of at least two osteosynthesis screws on the orbital rim from a previous surgery. Dedicated orthognathic surgery software was used to fuse the maxillary dental scan with the computed tomography and generate a dental splint, which was imported into the navigation software and augmented with fiducial markers. Registration points were indicated virtually and the augmented splint was three-dimensionally printed. Intraoperatively, the splint was fitted on the maxillary dentition and the fiducial markers were used for registration. Accuracy of the registration procedure was quantified by calculating the difference between the landmarks acquired by indicating the pre-existing osteosynthesis material with the navigation pointer and in the virtual planning software. After acquisition of the landmarks, the screws were removed and surgery proceeded according to plan. A median target registration error of 1.53 mm was found. The advantages of the virtual splint registration workflow are that it does not require extensive computer-aided design skills or repeated preoperative imaging, and is non-invasive.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of computer-simulated mandibular autorotation following single-jaw maxillary repositioning surgery using customized surgical cutting guides and fixation plates. 使用定制的外科切割导轨和固定板进行单颌上颌复位手术后计算机模拟下颌自旋的准确性。

International journal of oral and maxillofacial surgery Pub Date : 2025-02-05 DOI: 10.1016/j.ijom.2025.01.017

C Vu, J K Hartsfield, A Mian, B Allan, D Gebauer, M Goonewardene

{"title":"Accuracy of computer-simulated mandibular autorotation following single-jaw maxillary repositioning surgery using customized surgical cutting guides and fixation plates.","authors":"C Vu, J K Hartsfield, A Mian, B Allan, D Gebauer, M Goonewardene","doi":"10.1016/j.ijom.2025.01.017","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.017","url":null,"abstract":"The literature on computer-aided surgical simulation (CASS) has focused extensively on the precision and accuracy of maxillary and mandibular repositioning surgery. However, the predictability of mandibular autorotation remains understudied. The aim of this study was to evaluate the accuracy of CASS-planned mandibular autorotation in 50 consecutive patients undergoing maxillary repositioning surgery with customized titanium surgical cutting guides and fixation plates. The study patients (32 male and 18 female, mean age 25 years for both sexes) underwent Le Fort I osteotomy, with or without simultaneous genioplasty were performed by one experienced maxillofacial surgeon. Preoperative and postoperative multi-slice computed tomography scans were superimposed and contrasted with the surgical plan to evaluate any discrepancies between the planned and observed mandibular positions after surgery. The translational movements of the maxilla were a median 0.38 mm transversely, mean -5.29 mm anteroposteriorly, and median -1.00 mm vertically. Using a computed mandibular centroid, the absolute linear and angular discrepancies between the planned and observed mandibular autorotation movements were found to be within the clinically significant thresholds of 1 mm and 2°, respectively. It is concluded that CASS-planned mandibular autorotation is predictable when maxillary down-grafting and impaction does not exceed 5 mm and 4 mm, respectively.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maxilla-first patient-specific osteosynthesis vs mandible-first bimaxillary orthognathic surgery using splints: a randomized controlled trial. 上颌优先患者特异性骨植入vs下颌骨优先双颌正颌手术使用夹板：一项随机对照试验。

International journal of oral and maxillofacial surgery Pub Date : 2025-02-04 DOI: 10.1016/j.ijom.2025.01.016

H van der Wel, R H Schepers, F Baan, F K L Spijkervet, J Jansma, J Kraeima

{"title":"Maxilla-first patient-specific osteosynthesis vs mandible-first bimaxillary orthognathic surgery using splints: a randomized controlled trial.","authors":"H van der Wel, R H Schepers, F Baan, F K L Spijkervet, J Jansma, J Kraeima","doi":"10.1016/j.ijom.2025.01.016","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.016","url":null,"abstract":"Patient-specific osteosynthesis plates and three-dimensional virtual surgical planning with patient-specific surgical guides have significantly advanced orthognathic surgery, enhancing surgical accuracy. This study compares the outcomes of the mandible-first approach using an intermediate splint and manually bent osteosynthesis plates with the maxilla-first approach utilizing patient-specific osteosynthesis fixation in bimaxillary orthognathic surgery. This multi-centre randomized controlled trial included 88 patients, with 77 completing the study. Patients were randomly assigned to either the 'mandible-first' group (mandible-first with an intermediate splint) or the 'maxilla-first with PSO' group (maxilla-first with patient-specific osteosynthesis). Postoperative evaluation using cone beam computed tomography images showed significantly lower deviations from the preoperative plan in the maxilla-first with PSO group compared to the mandible-first group, for anteroposterior (median 1.0 mm vs 1.8 mm, P = 0.008) and left/right translations (median 0.4 mm vs 0.8 mm, P = 0.003), and yaw rotation (median 0.5° vs 1.0°, P = 0.013). Regarding clinical accuracy (categorized as optimal, good, or suboptimal), 59.5% of the patients in the maxilla-first with PSO group had an optimal or good result compared to 17.5% in the mandible-first group. The study findings suggest the maxilla-first PSO approach offers enhanced accuracy, supporting its adoption in orthognathic surgery for better surgical outcomes.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanisms of temporomandibular joint degeneration in large animal models. 大型动物模型中颞下颌关节退化的分子机制。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-30 DOI: 10.1016/j.ijom.2025.01.007

J L G C Monteiro, Y M Sillmann, T M Kambakhsh, M Bei, F P S Guastaldi

{"title":"Molecular mechanisms of temporomandibular joint degeneration in large animal models.","authors":"J L G C Monteiro, Y M Sillmann, T M Kambakhsh, M Bei, F P S Guastaldi","doi":"10.1016/j.ijom.2025.01.007","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.007","url":null,"abstract":"The aim of this scoping review was to summarize the results of large animal models investigating the molecular mechanisms of temporomandibular joint degenerative diseases (TMJ-DD). A search of the PubMed/MEDLINE, Embase, and Cochrane Library databases was performed, up to April 2024, using specific terms related to large animals and TMJ-DD. Identified studies had to be published in English. Two reviewers independently selected articles based on the inclusion criteria, with disagreements resolved by a senior author. Compliance with the ARRIVE guidelines was assessed for all studies, evaluating adherence to reporting standards across 21 checklist items. The search yielded 649 non-duplicate articles, of which 616 were excluded after title and abstract screening . The remaining 33 articles and one additional study identified in a hand-search underwent full-text review . Ultimately, seven studies were included, with three focusing on sheep, two on horses, and two on pigs. This review summarizes the biological markers involved in TMJ-DD and discusses their relevance in developing targeted and minimally invasive strategies to prevent the initiation and/or progression of joint disease.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of unfavourable osteotomy on skeletal stability and temporomandibular joint symptoms in sagittal split ramus osteotomy. 矢状裂支截骨术中不良截骨对骨骼稳定性和颞下颌关节症状的影响。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-29 DOI: 10.1016/j.ijom.2025.01.011

S Ohba, R Shido, T Naruse, S Narahara, T Yamada

{"title":"Influence of unfavourable osteotomy on skeletal stability and temporomandibular joint symptoms in sagittal split ramus osteotomy.","authors":"S Ohba, R Shido, T Naruse, S Narahara, T Yamada","doi":"10.1016/j.ijom.2025.01.011","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.011","url":null,"abstract":"This study was performed to investigate the impact of the split line on postoperative stability and temporomandibular joint (TMJ) disorders (TMD) after sagittal split ramus osteotomy. Skeletal Class III malocclusion patients who underwent mandibular osteotomy with/without plate fixation between August 2008 and March 2023 were enrolled retrospectively. The osteotomy lines were divided into original sagittal split ramus (SSRO), short lingual (SLO), and short buccal (SBO) osteotomies. Skeletal stability was evaluated, and TMDs were assessed preoperatively. Overall, 135 patients (270 TMJs) (87 female, 48 male; mean age 23.7 ± 7.8 years) were included. Mean mandibular setback was 6.2 ± 2.9 mm. Skeletal stability was observed in all patients. TMD were recorded in 47 joints (17.4%) preoperatively and 15 joints (5.6%) postoperatively. When TMD were compared between joints with and without plate fixation, preoperative TMD was found to be improved in non-fixed joints (P = 0.004). On multivariate analysis, segment fixation (P = 0.040), the osteotomy line (SBO vs SLO/SSRO, P = 0.043), and preoperative TMD (P = 0.030) were associated with postoperative TMD. The results of this study suggest that no plate fixation after mandibular osteotomy may be beneficial when the split line is SBO or preoperative TMD is observed.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-tricalcium phosphate patient-specific gap implants in bilateral sagittal split osteotomy: an innovative treatment method to enhance the mandibular border contour. Part 1: concept and workflow. 双侧矢状面劈裂截骨术中β -磷酸三钙患者特异性间隙种植体：一种增强下颌边缘轮廓的创新治疗方法。第1部分：概念和工作流。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-22 DOI: 10.1016/j.ijom.2025.01.004

G R J Swennen, A Aksu, F Reinauer, L Pottel, Y Weinberg

{"title":"Beta-tricalcium phosphate patient-specific gap implants in bilateral sagittal split osteotomy: an innovative treatment method to enhance the mandibular border contour. Part 1: concept and workflow.","authors":"G R J Swennen, A Aksu, F Reinauer, L Pottel, Y Weinberg","doi":"10.1016/j.ijom.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.ijom.2025.01.004","url":null,"abstract":"Antegonial notching can occur after bilateral sagittal split osteotomy (BSSO) and may lead to unpleasant aesthetic outcomes in both young and older patients. This clinical study presents a new concept to potentially overcome this problem and describes the workflow. Beta-tricalcium phosphate patient-specific gap implants (β-TCP gap-PSIs) are biocompatible and resorbable bone grafts that are placed in the space of the osteotomy gap during orthognathic procedures; they are virtually planned and printed in 3D. Between July 9, 2017 and July 31, 2018, 14 patients received bilateral β-TCP gap-PSIs during BSSO procedures. Nine were female (64.3%) and five were male (35.7%); mean age at surgery was 32.4 ± 12.7 years and the mean sagittal advancement gap was 9.4 ± 1.74 mm. The immediate postoperative position of the β-TCP implants, as well as early and long-term complications were evaluated; the clinical follow-up was 5 years. Intraoperative placement of the β-TCP implants was achieved without early complications, and the mandibular border contour was rated as very good or good in 82.1% of sides. Two minor long-term complications occurred, resulting in a total grafting success rate of 92.9%. In conclusion, this initial study (part 1) showed the potential of the β-TCP gap-PSI concept in BSSO procedures to prevent antegonial notching, which is currently underestimated and underreported. However, further extensive quantitative assessment is mandatory and will be presented in part 2.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of orthognathic surgery on the cheek area using the Barcelona line. 使用巴塞罗那线的正颌手术对脸颊区域的影响。

International journal of oral and maxillofacial surgery Pub Date : 2025-01-15 DOI: 10.1016/j.ijom.2024.11.002

J S Vivas-Castillo, A Valls-Ontañón, O L Haas Junior, M Giralt-Hernando, G M Ragucci, F J Hernández-Alfaro

{"title":"Impact of orthognathic surgery on the cheek area using the Barcelona line.","authors":"J S Vivas-Castillo, A Valls-Ontañón, O L Haas Junior, M Giralt-Hernando, G M Ragucci, F J Hernández-Alfaro","doi":"10.1016/j.ijom.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.ijom.2024.11.002","url":null,"abstract":"A facial appearance of premature aging due to poor bone support of the soft tissues is frequently found in patients with midface hypoplasia. This study was performed to evaluate the changes in the soft tissues of the cheek area in patients subjected to bimaxillary orthognathic surgery. The cheek line angle and length of 27 consecutive patients who underwent bimaxillary surgery, were measured on cone beam computed tomography scans obtained before surgery and at 1 and 12 months after surgery using 3D software. Changes between time-points were analyzed. Bimaxillary surgery was virtually planned in all patients using the Barcelona line protocol. The results showed a mean decrease in cheek angle of 5 ± 5° (P < 0.001). This decrease was reflected in a more anterior-projected cheek and was related to forward movement of the upper and lower incisors (x-axis) (r = -0.469, P = 0.014 and r = -0.440, P = 0.021, respectively). There was 3D stability of the hard and soft tissue changes at the 1-year postoperative follow-up. The results indicate that bimaxillary surgery performed following the Barcelona line as a planning reference could improve midfacial soft tissue support by means of a more anterior-projected cheek.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0