International journal of laboratory hematology最新文献_第4页

Mitigating Lipemia Interference in Anti-Xa Activity Measurement Through High-Speed Centrifugation. 通过高速离心减轻抗 Xa 活性测量中的脂血干扰

International journal of laboratory hematology Pub Date : 2024-10-21 DOI: 10.1111/ijlh.14393

Agathe Herb, Clément Ousteland, Cléo Proch, Jordan Wimmer, Laurent Mauvieux, Laurent Sattler

引用次数: 0

Definition of Significant Platelet Clumping: Should We Review All Samples With a Platelet Clumping Flag From Automated Hematology Analyzer? 显著血小板聚集的定义：我们是否应该对自动血液分析仪上所有带有血小板凝集标记的样本进行复查？

International journal of laboratory hematology Pub Date : 2024-10-21 DOI: 10.1111/ijlh.14387

Suhyeon Woo, Bohyun Kim, Nam Hun Heo, Min-Sun Kim, Young Ahn Yoon, Young-Jin Choi

{"title":"Definition of Significant Platelet Clumping: Should We Review All Samples With a Platelet Clumping Flag From Automated Hematology Analyzer?","authors":"Suhyeon Woo, Bohyun Kim, Nam Hun Heo, Min-Sun Kim, Young Ahn Yoon, Young-Jin Choi","doi":"10.1111/ijlh.14387","DOIUrl":"https://doi.org/10.1111/ijlh.14387","url":null,"abstract":"Objectives: This study aimed to determine a definition for significant platelet clumping (PC) and evaluate the performance of the Sysmex XN instrument for detecting platelet clumps.Methods: For part 1, 372 specimens with a 'PLT_clump?' flag in XN-9000 were classified into five groups according to the average number of PCs. We compared the initial platelet count (measured by XN-9000 using impedance method) and corrected platelet count (counted optically or re-analyzed by XN-9000 using vortexed or re-collected sample) of each group. For part 2, 1000 specimens with a PC flag divided into three subgroups {group N (PC = 0), Y (PC ≥ 1), and Z (microscopic fibrin clot)} and additional two groups {group S (PC(+) specimens without any flag and with flags of other categories) and group NC (negative control)} were collected. Positive predictive value (PPV), negative predictive value (NPV), sensitivity and specificity of PC detection of XN-9000 were obtained and the platelet counts and four indices (PDW, MPV, P_LCR, and PCT) of groups NC, N, Y, Z, and S were compared to detect PC more precisely.Results: In part 1, all groups showed significant difference between the initial and corrected platelet counts. In part 2, PPV, NPV, prevalence, sensitivity, and specificity were 41.5%, 56.5%, 43.4%, 2.18%, and 98.3%, respectively. The platelet counts and four indices showed statistical differences for detecting PCs, and especially PDW and P_LCR were significantly smaller in group Z than group N or Y.Conclusions: We suggest the definition of significant PC by the presence of at least three platelets. In addition, utilizing platelet-related indices should be developed to improve the efficiency of the PC detection.","PeriodicalId":94050,"journal":{"name":"International journal of laboratory hematology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unusual Presentation of EATL. 不寻常的 EATL 演示。

International journal of laboratory hematology Pub Date : 2024-10-21 DOI: 10.1111/ijlh.14389

Radu Chiriac, Lucile Baseggio

引用次数: 0

Negative Expression of CD117 Predicted Inferior OS and PFS in Acute Promyelocytic Leukemia. CD117 阴性表达可预测急性早幼粒细胞白血病较差的 OS 和 PFS。

International journal of laboratory hematology Pub Date : 2024-10-17 DOI: 10.1111/ijlh.14380

Jiangjun Yuan, Qiong Wang

引用次数: 0

Acute Mast Cell Leukemia With Complex Karyomorphism and Karyotypes. 具有复杂核形态和核型的急性肥大细胞白血病

International journal of laboratory hematology Pub Date : 2024-10-16 DOI: 10.1111/ijlh.14384

Sha Li, Yantian Zhao

{"title":"Acute Mast Cell Leukemia With Complex Karyomorphism and Karyotypes.","authors":"Sha Li, Yantian Zhao","doi":"10.1111/ijlh.14384","DOIUrl":"https://doi.org/10.1111/ijlh.14384","url":null,"abstract":"A 51-year-old woman visited the emergency department because of intermittent fever for more than 2 weeks. Physical examination found symmetrical pitting edema of the extremities. Computed tomography and ultrasound showed multiple serous effusions and splenomegaly. A complete blood cell analysis showed moderate anemia and severe thrombocytopenia. Abnormal cells in a subsequent peripheral blood smear accounted for 5%. The bone marrow smear showed a large number of abnormal cells (69.5%), with large cell bodies and pseudopod protrusions. Huge multinucleated cells were visible. Nucleoli were visible in some nuclei, and mitotic figures were evident. The abnormal cells by peroxidase staining were negative, and the positive rate by periodic acid-Schiff staining was 62%. Bone marrow biopsy revealed diffuse infiltration of heterotypic cells (approximately 80%). Later, she was transferred to the hematology department. The phenotypes by flow cytometry were CD117bri+, CD30+, MPO-, CD2-, and CD25-. The molecular test for KIT gene mutation was negative, and multiple karyotypes were abnormal and complex. The final diagnosis was mast cell leukemia. The patient eventually died approximately 1 month after the diagnosis.","PeriodicalId":94050,"journal":{"name":"International journal of laboratory hematology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preanalytical Conditions Impact Fibrin Monomers but Not D-Dimer: A Study With Rigorous Comparisons of a Broad Range of Simulated Conditions. 分析前条件影响纤维蛋白单体而非 D-二聚体：一项对多种模拟条件进行严格比较的研究。

International journal of laboratory hematology Pub Date : 2024-10-16 DOI: 10.1111/ijlh.14385

Hachem Zakaria Bouarroudj, Michaël Hardy, Thomas Lecompte, François Mullier

引用次数: 0

Acute Myeloid Leukaemia With Morphologic and Immunophenotypic Differentiation to Acute Erythroid Leukaemia at the Time of Relapse. 复发时形态学和免疫分型分化为急性红细胞白血病的急性髓性白血病

International journal of laboratory hematology Pub Date : 2024-10-15 DOI: 10.1111/ijlh.14386

Katie Liston, Vitaliy Mykytiv

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Chronic Myeloid Leukaemia (CML) in T-Lymphoblastic Blast Crisis With Near Early T Cell Progenitor (ETP) Immunophenotype. T淋巴细胞突变危象中的慢性髓性白血病（CML），免疫表型接近早期T细胞祖细胞（ETP）。

International journal of laboratory hematology Pub Date : 2024-10-11 DOI: 10.1111/ijlh.14383

Ke Xu, Evan Vistsaras, Rajeev Gupta

引用次数: 0

Current Diagnosis of Bleeding Disorders in Lower Income Countries. 低收入国家目前对出血性疾病的诊断。

International journal of laboratory hematology Pub Date : 2024-10-11 DOI: 10.1111/ijlh.14377

Deepak K Mishra, Asish Rath, Mayur Parihar, Sushant S Vinarkar, Anirban Kundu

{"title":"Current Diagnosis of Bleeding Disorders in Lower Income Countries.","authors":"Deepak K Mishra, Asish Rath, Mayur Parihar, Sushant S Vinarkar, Anirban Kundu","doi":"10.1111/ijlh.14377","DOIUrl":"https://doi.org/10.1111/ijlh.14377","url":null,"abstract":"There have been considerable advances in diagnosing and treating bleeding disorders. But the scenario remains dismal in resource-constrained settings in low and lower-middle-income countries (LMICs). Seventy-five percent of the patients with inherited bleeding disorders do not get diagnosed in LMICs. In resource-constrained settings, infectious disease and malignancies take the major focus. Bleeding disorders do not get prioritised in LMICs, and this leads to underdiagnoses and suboptimal treatment. There are various challenges like financial status, inadequacy of health care infrastructure, lack of patient registry and lack of awareness across medical staff, general population and government stakeholders. The lack of skilled laboratory personnel and laboratory infrastructure for optimal bleeding disorder diagnosis adds on to the problem. World Federation of Hemophilia (WFH) has been at the forefront in developing strategies to overcome some of these inadequacies; however, more active participation of the stakeholders including patients, medical professionals and policy makers is the need of the hour. This review highlights the different challenges in LMICs in diagnosing bleeding disorders, the gap between high-income countries and LMICs and the possible strategies in closing the gap.","PeriodicalId":94050,"journal":{"name":"International journal of laboratory hematology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of a Lymphoproliferative Disorder With Suspected Scattergram Analysis Using the Mindray BC-6800 Plus Automated Hematology Analyzer: A Case Report. 使用 Mindray BC-6800 Plus 全自动血液分析仪进行散点图分析发现淋巴组织增生性疾病：病例报告。

International journal of laboratory hematology Pub Date : 2024-10-10 DOI: 10.1111/ijlh.14378

Sara Sacchetti, Matteo Bellia, Valentina Zanotti, Luca Giacomini, Roberta Rolla

引用次数: 0