International journal of laboratory hematology最新文献

Binucleated Lymphocytes With Globular Inclusions in Relapsed Splenic Marginal Zone Lymphoma. 复发性脾边缘区淋巴瘤中带有球状包涵体的双核淋巴细胞

International journal of laboratory hematology Pub Date : 2024-09-06 DOI: 10.1111/ijlh.14364

Verónica Roldán Galiacho, Marta Dueñas Usategui, Marta Alonso Varela, Elena Amutio, Juan Carlos García-Ruiz

引用次数: 0

Evaluation of the immature platelet fraction as a predictive marker of bone marrow regeneration after hematopoietic stem cell transplantation. 评估作为造血干细胞移植后骨髓再生预测标志的未成熟血小板部分。

International journal of laboratory hematology Pub Date : 2024-09-04 DOI: 10.1111/ijlh.14358

Kélian Steibel, Magalie Joris, Valentin Clichet, Amandine Charbonnier, Judith Desoutter, Jean-Pierre Marolleau, Loïc Garçon, Thomas Boyer

{"title":"Evaluation of the immature platelet fraction as a predictive marker of bone marrow regeneration after hematopoietic stem cell transplantation.","authors":"Kélian Steibel, Magalie Joris, Valentin Clichet, Amandine Charbonnier, Judith Desoutter, Jean-Pierre Marolleau, Loïc Garçon, Thomas Boyer","doi":"10.1111/ijlh.14358","DOIUrl":"https://doi.org/10.1111/ijlh.14358","url":null,"abstract":"Introduction: Hematopoietic stem cell transplantation (HCST) is a widely used therapy in the management of hematological malignancies, leading to cytopenias that require transient transfusions. Platelet recovery (PR) following HSCT is assessed by monitoring platelet count (PC). Immature platelet fraction (IPF) is a research parameter offered by Sysmex® on XN series analyzers, enabling rapid diagnostic orientation in the event of thrombocytopenia. It has also been described as a predictive factor for PR after chemotherapy or HSCT, and thresholds have been proposed.Methods: The objective of this study was to assess the predictive capability of IPF for PR in a prospective cohort of patients undergoing HSCT and to evaluate its utility in guiding platelet transfusion decision.Results: An optimized A-IPF (absolute number of IPF) threshold of 2.5 × 109/L was predictive of a PC greater than 50 × 109/L at day 30 with a sensitivity of 78.9%, specificity of 78.6%, positive predictive value (PPV) of 83.3% and negative predictive value (NPV) of 73.3%. We were able to distinguish patients recovering PC before day 15 with an earlier %IPF peak, greater IPF recovery kinetics and faster neutrophil recovery.Conclusion: A-IPF shows promise as a predictor of PR following HSCT. A multicenter study could help confirm both A-IPF and %IPF (IPF) clinical utility before it is made available to clinicians.","PeriodicalId":94050,"journal":{"name":"International journal of laboratory hematology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence-Based Platelet Count, Blood Smear and Pre-Analytics Are Decisive in a Case of Fibrin Strand Interference Masking Severe Thrombocytopenia in an ITP Patient. 基于荧光的血小板计数、血涂片和预分析在一例因纤维蛋白束干扰而掩盖严重血小板减少的 ITP 患者中起决定性作用。

International journal of laboratory hematology Pub Date : 2024-09-03 DOI: 10.1111/ijlh.14367

Marnix Mylemans, Nancy Boeckx, Ann Janssens, Mercedeh Tajdar, Christine Van Laer

引用次数: 0

Delta Immature Platelet Fraction Is Associated With Mortality in Bacteremia Patients. 德尔塔不成熟血小板比例与菌血症患者的死亡率有关。

International journal of laboratory hematology Pub Date : 2024-09-02 DOI: 10.1111/ijlh.14365

Pei-Chun Shih, Yi-Hua Wang, Shey-Ying Chen, Min Tseng, Cheng-An Hsu, Ming-Yan Yang, Hsin-Yao Wang, Jia-Arng Lee

{"title":"Delta Immature Platelet Fraction Is Associated With Mortality in Bacteremia Patients.","authors":"Pei-Chun Shih, Yi-Hua Wang, Shey-Ying Chen, Min Tseng, Cheng-An Hsu, Ming-Yan Yang, Hsin-Yao Wang, Jia-Arng Lee","doi":"10.1111/ijlh.14365","DOIUrl":"https://doi.org/10.1111/ijlh.14365","url":null,"abstract":"Objectives: Immature platelet fraction (IPF) for differentiating bacteremia has been explored, whereas its prognostic correlation remains uncertain. This study aims to confirm the predictive capability of IPF for bacteremia and investigate its association with prognosis.Methods: Patients with complete blood count (CBC) on the blood culture day (D1) and the preceding day (D0) were retrospectively recruited and categorized into bacteremia and nonbacteremia groups. Immature platelet (IP) analysis, alongside CBC, was conducted. Delta IPF, defined by the absolute values of D1 minus D0 results was calculated. The ability to distinguish bacteremia from nonbacteremia patients, and the correlation with mortality were analyzed.Results: From February to December 2020, a total of 150 patients were enrolled, with 75 having bacteremia. The specificity for delta IPF ≥3.4% to predict bacteremia was 97.3% (95% confidence interval [CI]: 90.7-99.7). When delta IPF ≥3.4% combined with procalcitonin ≥0.5 (ng/mL), the sensitivity was 90.5% (95% CI: 69.6%-98.8%). Within the bacteremia group, delta IPF and the proportion of patients with delta IPF ≥1.5% were significantly higher in nonsurvival, while delta platelet levels did not. Furthermore, delta IPF ≥1.5% was independently associated with 30-day mortality (adjusted odds ratio: 3.88, 95% CI: 1.2%-11.4%; p = 0.020). The 30-day survival curve demonstrated a significant difference between patients with delta IPF ≥1.5% and those without (p < 0.001).Conclusions: Delta IPF correlates with mortality in bacteremia patients. Our findings suggest IPF not only helps detect bacteremia but also predicts prognosis in the early stage.","PeriodicalId":94050,"journal":{"name":"International journal of laboratory hematology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishing reference intervals for extended red blood cell parameters with the Mindray BC-6800Plus hematology analyzer in a Chinese population. 在中国人群中使用明德 BC-6800Plus 血液分析仪建立扩展红细胞参数参考区间。

International journal of laboratory hematology Pub Date : 2024-08-23 DOI: 10.1111/ijlh.14361

Yanping Luo, Shuaiyan Wang, Zhuocheng Chen, Shan Lin, Sanping Guo, Hongmei Mo

引用次数: 0

Brief communication: Heparin-calibrated chromogenic anti-Xa assay for the detection of threshold-levels of direct oral anticoagulants. 简要通讯：用于检测直接口服抗凝剂阈值水平的肝素校准显色抗 Xa 试验。

International journal of laboratory hematology Pub Date : 2024-08-23 DOI: 10.1111/ijlh.14357

Delphine De Smet, Dimitri Hemelsoet, Veerle De Herdt, Pieter M De Kesel, Katrien M J Devreese

引用次数: 0

Myeloid sarcoma of the breast with synchronous early T-cell precursor acute lymphoblastic leukemia: A rare presentation. 乳腺髓样肉瘤伴同步早期T细胞前体急性淋巴细胞白血病：罕见病例。

International journal of laboratory hematology Pub Date : 2024-08-19 DOI: 10.1111/ijlh.14360

Subhajit Hajra, Kavya Ur, Zahed Ali Qamer, Karthik Kumar, Priyavadhana Balasubramanian, Gaurav Dhingra, Neha Singh, Nilotpal Chowdhury

引用次数: 0

An automated method for thrombocyte counting in capillary microsamples. 毛细管微型样本中血小板计数的自动方法。

International journal of laboratory hematology Pub Date : 2024-08-14 DOI: 10.1111/ijlh.14354

Caroline Vasard Boesen, Vibeke Staun Christensen, Klaus Rosenkilde Jensen, Anja Reinert Hansen, Claus Vinter Bødker Hviid

{"title":"An automated method for thrombocyte counting in capillary microsamples.","authors":"Caroline Vasard Boesen, Vibeke Staun Christensen, Klaus Rosenkilde Jensen, Anja Reinert Hansen, Claus Vinter Bødker Hviid","doi":"10.1111/ijlh.14354","DOIUrl":"https://doi.org/10.1111/ijlh.14354","url":null,"abstract":"Introduction: We aimed to develop an automated, low-volume method for thrombocyte counting in capillary blood using the Sysmex predilution (PD) mode.Methods: Microsamples were prepared by resuspension of 50 μL blood in 300 μL DCL CellPack. Thrombocyte counting was done in the impedance (PLT-I) and fluorescence (PLT-F) channels. The imprecision and bias was evaluated in >394 microsamples from adult blood. Preanalytical factors (skin-piercing, storage, and transportation in our pneumatic tube system) was assessed, and studies on pediatric microsamples were made for comparison. The improvement in analytical quality and turnaround time was examined.Results: For PLT-F, the imprecision was 1.1%-3.7%, and the bias was 10.1% (95% CI: 8.8-11.3). After skin-piercing, the bias was 8.1% (95% CI: 5.6-10.6) and the imprecision 1.9% (95% CI: 1.3-2.5). Thrombocyte counts kept stable after 4 h at room temperature (94.8% [95% CI: 93.2-96.4]) and after pneumatic tube transportation [6.7% (95% CI: 4.8-8.6)]. The bias of the PD mode for pediatric microsamples was 13.0% (95% CI: -8.4-34.4) in the PLT-F channel. The automated method had a considerably lower imprecision than the existing manual thrombocyte counting method and reduced turnaround times.Conclusion: The automated microsample method offers a low-volume alternative for measurement of thrombocytes. The method appears useful also in pediatric samples.","PeriodicalId":94050,"journal":{"name":"International journal of laboratory hematology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of bone marrow infiltration by Langerhans cell with bilobed and folded lobulated nuclei. 一个罕见的朗格汉斯细胞骨髓浸润病例，其细胞核呈双叶和折叠分叶状。

International journal of laboratory hematology Pub Date : 2024-08-14 DOI: 10.1111/ijlh.14362

Jinshuang Bo, Shuai Wang, Shenghai Gao, Xiaowen Xin

引用次数: 0

Mature plasmacytoid dendritic cell proliferation associated with acute myeloid leukemia. 与急性髓性白血病相关的成熟浆细胞树突状细胞增殖。

International journal of laboratory hematology Pub Date : 2024-08-10 DOI: 10.1111/ijlh.14356

J Maes, H Devos, B Cauwelier, P De Paepe, J Emmerechts

引用次数: 0