Frontiers in oral health最新文献

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Innovations on the horizon: teledentistry, artificial intelligence, and hybrid models to improve oral health for vulnerable communities. 即将出现的创新:远程牙科、人工智能和混合模式,以改善弱势群体的口腔健康。
IF 3.1
Frontiers in oral health Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI: 10.3389/froh.2025.1649715
Sergiu Drafta, Andrei Macris, Alexandru E Petre
{"title":"Innovations on the horizon: teledentistry, artificial intelligence, and hybrid models to improve oral health for vulnerable communities.","authors":"Sergiu Drafta, Andrei Macris, Alexandru E Petre","doi":"10.3389/froh.2025.1649715","DOIUrl":"10.3389/froh.2025.1649715","url":null,"abstract":"<p><strong>Objectives: </strong>Vulnerable populations experience substantial challenges accessing dental care, leading to disproportionate oral health burdens. Digital solutions, such as teledentistry and artificial intelligence, offer new opportunities to improve access, quality and effectiveness of the care.</p><p><strong>Methods: </strong>This paper presents a narrative literature review incorporating findings from peer-reviewed journals, systematic reviews, and case studies retrieved from PubMed, Scopus, and Web of Science (2013-2024). Evidence was also synthesized using the artificial intelligence tool Elicit to include high-quality data on teledentistry, artificial intelligence and hybrid dental care models, focusing on their implementation and effectiveness. Studies were selected to address relevance for underserved populations and digital innovation in dental care delivery.</p><p><strong>Results: </strong>Teledentistry modalities, including e-consults and virtual dental homes, have demonstarte enhanced access and delivery of preventative care. Artificial intelligence tool provide accurate diagnoses, predict treatment needs, and streamline workflows. Hybrid models combining virtual screening with in-person treatment bridge care gaps and enhance continuity and efficiency, particularly for underserved populations.</p><p><strong>Conclusions: </strong>The integration of teledentistry, artificial intelligence and hybrid dental practice models offers a transformative approach to improving oral health care acces and equity. However, success will require investment, support and collaboration to scale these innovations effectively.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1649715"},"PeriodicalIF":3.1,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current perspectives and trend of ferroptosis in head and neck cancer: a bibliometric analysis. 头颈癌中铁下垂的现状和趋势:文献计量学分析。
IF 3.1
Frontiers in oral health Pub Date : 2025-08-08 eCollection Date: 2025-01-01 DOI: 10.3389/froh.2025.1601962
Jin Pan, Yi Zhang, Binbin Zhao, Wei Shao, Xin Chen
{"title":"Current perspectives and trend of ferroptosis in head and neck cancer: a bibliometric analysis.","authors":"Jin Pan, Yi Zhang, Binbin Zhao, Wei Shao, Xin Chen","doi":"10.3389/froh.2025.1601962","DOIUrl":"10.3389/froh.2025.1601962","url":null,"abstract":"<p><strong>Background: </strong>Ferroptosis, a form of regulated cell death driven by iron dependency, is also referred to as iron-mediated cell death. In recent years, ferroptosis has garnered considerable research interest as a distinct cell death mechanism, primarily characterized by excessive intracellular iron accumulation and the formation of lipid peroxides. Ferroptosis is intricately linked to the initiation and progression of a wide spectrum of diseases, notably cancers, neurodegenerative disorders-including Alzheimer's and Parkinson's diseases-and cardiovascular conditions. Despite growing interest in ferroptosis within cancer research, systematic analyses and comprehensive visualizations of research hotspots, leading contributors, and emerging trends-particularly in the context of head and neck cancers-remain limited.</p><p><strong>Materials and methods: </strong>This study conducted a bibliometric analysis using data retrieved from the Web of Science Core Collection, covering the period from January 1, 2016, to March 20, 2025. Bibliometric mapping and visualization were performed using VOSviewer and CiteSpace.</p><p><strong>Results: </strong>A total of 110 publications were identified across 19 countries. China contributed the highest number of publications (84 articles; 76.36%), followed by South Korea (14 articles; 12.73%) and the United States (6 articles; 5.46%). <i>Nature</i>, <i>Cell</i>, and <i>Cancer Letters</i> emerged as the leading academic journals publishing on ferroptosis in the context of head and neck cancers. Emerging high-frequency keywords-such as \"expression\" \"cell death\" \"ferroptosis\" \"inhibition\" \"metabolism\" and \"therapy\"-highlight evolving research frontiers in this field.</p><p><strong>Conclusion: </strong>This study presents a comprehensive overview of recent trends and advances in ferroptosis research within the context of head and neck cancer, delineating key research frontiers and emerging thematic areas. The findings offer valuable insights and serve as a useful reference for researchers pursuing work in this domain.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1601962"},"PeriodicalIF":3.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Teledentistry in Jordan: assessing knowledge and attitudes among dentists. 约旦的远程牙科:评估牙医的知识和态度。
IF 3.1
Frontiers in oral health Pub Date : 2025-08-08 eCollection Date: 2025-01-01 DOI: 10.3389/froh.2025.1619119
Tamadur Mahmoud Falah, Sabha Mahmoud Alshatrat, Jumana M Sabarini, Majd M Alsaleh, Yousef Saleh Khader, Alaa Fawwaz Dalky, Bayan Jamal Almahasneh, Abedelmalek Kalefh Tabnjh
{"title":"Teledentistry in Jordan: assessing knowledge and attitudes among dentists.","authors":"Tamadur Mahmoud Falah, Sabha Mahmoud Alshatrat, Jumana M Sabarini, Majd M Alsaleh, Yousef Saleh Khader, Alaa Fawwaz Dalky, Bayan Jamal Almahasneh, Abedelmalek Kalefh Tabnjh","doi":"10.3389/froh.2025.1619119","DOIUrl":"10.3389/froh.2025.1619119","url":null,"abstract":"<p><strong>Aim: </strong>to evaluate the perceptions, knowledge, and attitudes of Jordanian dentists towards teledentistry.</p><p><strong>Methods: </strong>A web-based, anonymous, self-administered closed-end questionnaire was distributed across Jordan. Conducted with a sample of 250 dentists selected through convenience sampling, the research assessed knowledge and attitudes using a pre-designed and validated questionnaire. An electronic link was sent to active Jordanian Dental Association (JDA) members. The survey consisted of three sections with closed questions.</p><p><strong>Results: </strong>A total of 250 dentists (Male 52%) participated in the study. The mean knowledge and attitude scores were 78.78 ± 15.27 and 76.81 ± 14.74, respectively. Dentists without postgraduate qualifications demonstrated significantly greater knowledge compared to those with postgraduate qualifications (<i>p</i> = 0.023). Over half of the respondents agreed that teledentistry is effective for diagnosing and providing treatment recommendations from a distance and can assist in monitoring patients' oral health. However, the majority disagreed with its application across all branches of dentistry. A significant number of participants believed that teledentistry could improve access to oral healthcare, reduce costs, save time for dentists, increase accessibility in rural and underserved areas, and reduce isolation among practitioners by facilitating peer contact and specialist support. <i>T</i>-test and one-way ANOVA were used to test the mean difference of the knowledge and attitude percentages for the subcategories. Chi-square tests revealed a significant association between knowledge and attitude toward teledentistry and demographic characteristics of the participants. Also, the test revealed a significant difference in respondents' workplace settings regarding their views on teledentistry's impact on monitoring patients' oral health (<i>p</i> = 0.026), its potential for integration into current dental services (<i>p</i> = 0.001), and time-saving benefits (<i>p</i> = 0.007). The results suggest participants with less than 10 years of experience were more likely to agree that teledentistry can improve access to oral health care (<i>p</i> = 0.039). Similarly, participants also more likely to agree that teledentistry has the potential to be integrated into current dental services (<i>p</i> = 0.029).</p><p><strong>Conclusion: </strong>Teledentistry has the potential to provide equitable, cost-effective, and high-quality dental care especially for individuals in remote areas with limited access to traditional dental care.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1619119"},"PeriodicalIF":3.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel antimicrobial and bioactive resin-based clear aligner attachment orthodontic materials. 新型抗菌和生物活性树脂基透明对准器附着正畸材料。
IF 3.1
Frontiers in oral health Pub Date : 2025-08-07 eCollection Date: 2025-01-01 DOI: 10.3389/froh.2025.1630019
Heba Alqarni, Ibrahim Ba-Armah, Nader Almutairi, Mohammad Alenizy, Dwayne D Arola, Thomas W Oates, Jirun Sun, Michael D Weir, Hockin H K Xu
{"title":"Novel antimicrobial and bioactive resin-based clear aligner attachment orthodontic materials.","authors":"Heba Alqarni, Ibrahim Ba-Armah, Nader Almutairi, Mohammad Alenizy, Dwayne D Arola, Thomas W Oates, Jirun Sun, Michael D Weir, Hockin H K Xu","doi":"10.3389/froh.2025.1630019","DOIUrl":"10.3389/froh.2025.1630019","url":null,"abstract":"<p><strong>Introduction: </strong>Clear aligner orthodontic treatment provides a hygienic and esthetic alternative to fixed appliances; however, the required resin attachments can promote plaque accumulation and increase the risk of white-spot lesions in enamel. This study aimed to develop a novel resin-based antibacterial and bioactive orthodontic clear aligner attachment and evaluate its mechanical and antibacterial properties.</p><p><strong>Methods: </strong>A resin matrix composed of urethane dimethacrylate (UDMA) and triethylene glycol divinylbenzyl ether (TEG-DVBE) was modified with 3% dimethylaminododecyl methacrylate (DMADDM) for antibacterial effects and nano-amorphous calcium phosphate (NACP) to support remineralization. Transbond™ LV and Vitremer™ were selected as commercial controls. Mechanical properties (flexural strength, elastic modulus, microhardness, and shear bond strength), degree of conversion, and antibacterial performance against <i>Streptococcus mutans (S. mutans)</i> biofilms were assessed through colony forming units (CFU), biofilm metabolic activity (MTT), and lactic acid production.</p><p><strong>Results: </strong>All experimental groups showed flexural strength of 100.6-109.2 MPa, exceeding the ISO standard for resin-based materials. Degree of conversion in experimental groups ranged from (53.4 ± 2.3 to 69 ± 0.9) %, significantly exceeding (47.5 ± 0.1) % for Transbond control (<i>p</i> < 0.05). Hardness was (0.21 ± 0.03) GPa for Transbond control, statistically comparable to (0.20 ± 0.02) GPa for the 20% NACP + 45% glass group. All experimental groups achieved a 6-log reduction in biofilm CFU and 90% reduction in metabolic activity and lactic acid production vs. controls (<i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>This novel clear aligner attachment resin exhibits promising mechanical strength, high degree of conversion, potent antibacterial effects, and ion releases to potentially reduce white-spot lesions during clear aligner treatment.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1630019"},"PeriodicalIF":3.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating haptic simulation in dentistry: faculty insights and future directions. 整合牙科触觉模拟:教师的见解和未来的方向。
IF 3.1
Frontiers in oral health Pub Date : 2025-08-06 eCollection Date: 2025-01-01 DOI: 10.3389/froh.2025.1592095
Danya Hashem, Abeer Farag, Amnah A Algarni, Rania Zahran Mubarak, Nisreen Nabiel Hassan, Anfal Alqussier, Somaya Ali Saleh
{"title":"Integrating haptic simulation in dentistry: faculty insights and future directions.","authors":"Danya Hashem, Abeer Farag, Amnah A Algarni, Rania Zahran Mubarak, Nisreen Nabiel Hassan, Anfal Alqussier, Somaya Ali Saleh","doi":"10.3389/froh.2025.1592095","DOIUrl":"10.3389/froh.2025.1592095","url":null,"abstract":"<p><strong>Purpose: </strong>Evaluate the knowledge of faculty members about haptic virtual reality simulation (HVRS) in dentistry and assess faculty members' perception towards the use of HVRS in dental education.</p><p><strong>Methods: </strong>This interventional study involved distributing a questionnaire to 29 faculty members from different dental specialties as a baseline before attending a hands-on workshop on HVRS followed by another questionnaire distributed after the workshop. Data was analyzed using IBM SPSS version 26, employing chi-squared tests for statistical significance.</p><p><strong>Results: </strong>Around 69% of faculty members had heard of HVRS prior to the study, but 86% had no prior experience using it. There was an increase in the willingness to use HVRS in teaching and to be included as an adjunct to pre-clinical and clinical training after attending the workshop. Post-training assessments indicated a significant shift in perceptions, with faculty expressing high satisfaction regarding the ergonomic design, visual system, and usability of the Simodont® simulator. Participants agreed that HVRS could enhance students' manual skills and self-evaluation capabilities.</p><p><strong>Conclusion: </strong>Faculty members at Taibah University expressed a positive perception of the use of HVRS in dental education and a willingness to adopt HVRS as a teaching aid. They intend to incorporate it into pre-clinical and clinical training. Although the study has a small sample size, it highlights the need for ongoing faculty training to facilitate the integration of HVRS technology in dental education, while also calling for further research to explore its long-term effects on learning outcomes.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1592095"},"PeriodicalIF":3.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Oral health care for vulnerable and underserved populations. 社论:弱势和服务不足人群的口腔卫生保健。
IF 3.1
Frontiers in oral health Pub Date : 2025-08-06 eCollection Date: 2025-01-01 DOI: 10.3389/froh.2025.1633512
Adriana Modesto, Apoena Aguiar Ribeiro
{"title":"Editorial: Oral health care for vulnerable and underserved populations.","authors":"Adriana Modesto, Apoena Aguiar Ribeiro","doi":"10.3389/froh.2025.1633512","DOIUrl":"10.3389/froh.2025.1633512","url":null,"abstract":"","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1633512"},"PeriodicalIF":3.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Standardized coronectomy versus total extraction for impacted mandibular third molars: a single-blinded prospective analysis of patient-reported outcomes. 标准冠切除术与全拔牙治疗阻生下颌第三磨牙:患者报告结果的单盲前瞻性分析。
IF 3.1
Frontiers in oral health Pub Date : 2025-08-05 eCollection Date: 2025-01-01 DOI: 10.3389/froh.2025.1647852
Mohamad Khalid Al-Ali, Roba Saqan, Sarah Alkhazraji, Kamis Gaballah
{"title":"Standardized coronectomy versus total extraction for impacted mandibular third molars: a single-blinded prospective analysis of patient-reported outcomes.","authors":"Mohamad Khalid Al-Ali, Roba Saqan, Sarah Alkhazraji, Kamis Gaballah","doi":"10.3389/froh.2025.1647852","DOIUrl":"10.3389/froh.2025.1647852","url":null,"abstract":"<p><strong>Introduction: </strong>Coronectomy is proposed as an alternative to surgical extraction for impacted mandibular third molars, particularly in cases with an elevated surgical risk of inferior alveolar nerve injury. However, this procedure is not widely adopted by many surgeons due to concerns about potential complications and the perception that patients may be less likely to accept this treatment option.</p><p><strong>Methods: </strong>This cross-sectional, prospective, single-blinded study compared patient-reported outcomes between standardized coronectomy and extraction of impacted mandibular third molars in 70 patients (aged 19-55 years) using the Postoperative Symptom Severity (PoSSe) scale.</p><p><strong>Results: </strong>While coronectomy avoided nerve injury, it resulted in relatively longer recovery times (40% vs. 28.6% requiring ≥5 days) and prolonged medication use (34.3% vs. 14.3% >5 days) compared to extraction. Coronectomy patients reported significantly higher pain and swelling scores, particularly among females (>25 years), though neither procedure adversely affected eating, speech, or quality of life. Gender and age influenced outcomes, with females and older patients experiencing more pronounced postoperative morbidity after coronectomy.</p><p><strong>Discussion: </strong>These findings underscore the need for demographic-specific counseling and tailored postoperative care when selecting coronectomy. Further research with larger sample sizes is recommended to validate these findings and optimize decision-making for mandibular third molar surgeries.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1647852"},"PeriodicalIF":3.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of oral metronomic chemotherapy in the management of head and neck squamous cell carcinoma-a systematic review. 口服节律化疗治疗头颈部鳞状细胞癌疗效的系统评价。
IF 3.1
Frontiers in oral health Pub Date : 2025-07-30 eCollection Date: 2025-01-01 DOI: 10.3389/froh.2025.1632316
Aardra Binithadas Segin Chandran, Deepak Pandiar, Reshma Poothakulath Krishnan, Divya Gopinath
{"title":"Efficacy of oral metronomic chemotherapy in the management of head and neck squamous cell carcinoma-a systematic review.","authors":"Aardra Binithadas Segin Chandran, Deepak Pandiar, Reshma Poothakulath Krishnan, Divya Gopinath","doi":"10.3389/froh.2025.1632316","DOIUrl":"10.3389/froh.2025.1632316","url":null,"abstract":"<p><strong>Background: </strong>Head and neck squamous cell carcinoma (HNSCC) is a group of heterogeneous malignancies and constitutes one of the most prevalent forms of cancer. Oral metronomic chemotherapy (OMCT) is a treatment in which low doses of anticancer drugs are given at regular intervals over a long time, with many advantages over conventional therapies, particularly in nations with high cancer burden. The present systematic review aimed to evaluate the efficacy of OMCT in the management of HNSCC in comparison to other standard chemotherapy regimens. Methodology: The review was registered in the Prospero database (CRD42023426000). An electronic search was conducted using PubMed, Scopus, Web of Science and Google Scholar databases. Articles in which OMCT was used to treat HNSCC were included for systematic review, and the survival and response rates were analyzed.</p><p><strong>Results: </strong>Twenty-four eligible articles were included for evaluation, which revealed that administration of OMCT produced higher survival and response rates in subjects compared to standard chemotherapy.</p><p><strong>Conclusion: </strong>The evidence from the included studies supports that oral metronomic chemotherapy is substantially more effective as compared to standard chemotherapy regimens in squamous cell carcinomas of the head and neck.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42023426000, identifier (CRD42023426000).</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1632316"},"PeriodicalIF":3.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phospho-tau 181 is enhanced in saliva and plasma of edentulous patients: a first sign of dementia? 无牙患者唾液和血浆中磷酸化tau 181升高:痴呆的第一个征兆?
IF 3.1
Frontiers in oral health Pub Date : 2025-07-30 eCollection Date: 2025-01-01 DOI: 10.3389/froh.2025.1627681
Christine Zürcher, Michaela Defrancesco, Christian Humpel
{"title":"Phospho-tau 181 is enhanced in saliva and plasma of edentulous patients: a first sign of dementia?","authors":"Christine Zürcher, Michaela Defrancesco, Christian Humpel","doi":"10.3389/froh.2025.1627681","DOIUrl":"10.3389/froh.2025.1627681","url":null,"abstract":"<p><strong>Objectives: </strong>There is evidence that periodontitis can enhance the progression of Alzheimer's disease (AD). The biomarkers beta-amyloid (40 and 42), total tau, and phospho-tau181 (pTau181) in cerebrospinal fluid help to diagnose AD. Saliva is an easy-to-collect fluid and we aim to analyze these biomarkers in patients with periodontitis.</p><p><strong>Subjects and methods: </strong>Four groups of individuals were included: patients with healthy periodont, those with mild and severe periodontal diseases, and edentulous patients. These four biomarkers were analyzed in saliva using Lumipulse technology, and as a control, also cortisol, transferrin, and interleukin-6 were measured. Patients underwent a neuropsychological assessment, and plasma pTau181 was analyzed.</p><p><strong>Results: </strong>No changes were seen for salivary beta-amyloid and total tau; however, salivary pTau181 was significantly increased in edentulous patients. This was accompanied by enhanced plasma pTau181 levels.</p><p><strong>Conclusion: </strong>Our data show that pTau181 was significantly higher in saliva and plasma of edentulous patients, and we suggest that the loss of teeth may be linked to the progression of dementia. Consultation of dentists may be of importance to find risk factors for the progression of dementia, and salivary pTau181 could be a new associative marker.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1627681"},"PeriodicalIF":3.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A scoping review of school-based oral health interventions among adolescents in Nigeria. 尼日利亚以学校为基础的青少年口腔健康干预措施的范围审查。
IF 3.1
Frontiers in oral health Pub Date : 2025-07-29 eCollection Date: 2025-01-01 DOI: 10.3389/froh.2025.1577753
Abel Nnamdi Chukwuemeka, Richard Oveh, Anita Dabar, Omorinola Afolabi, Saheed Ademola Ibraheem, Folahanmi Tomiwa Akinsolu, Abideen Olurotimi Salako, Omolola Titilayo Alade, Foluso Owotade, George Uchenna Eleje, Oliver Ezechi, Joanne Lusher, Moréniké Oluwátóyìn Foláyan
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