Frontiers in oral health最新文献

{"title":"Redondovirius-associated periodontitis in people with poor oral hygiene: a cross-sectional study.","authors":"Alireza Mohebbi, Zakiyeh Donyavi, Zoleikha Mamizadeh, Khadijeh Khanaliha, Nikoo Emtiazi, Seyed Jalal Kiani, Tahereh Donyavi, Alireza Shadab, Roghayeh Babaei, Farah Bokharaei-Salim","doi":"10.3389/froh.2025.1572274","DOIUrl":"10.3389/froh.2025.1572274","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the prevalence of recently emerged members of the <i>Redondoviridae</i> family (ReDoVs) in individuals with periodontitis.</p><p><strong>Methods: </strong>This study involved real-world data from 230 participants, 115 with chronic periodontitis and an independent population consisting of 115 participants with oral hygiene habits selected from the refferals, and approved by the experts from October 2023 to May 2024. Demographic, health-related, and behavioral data were collected. Gingival samples were analyzed for ReDoVs using polymerase chain reaction (PCR), followed by sequencing and phylogenetic analysis.</p><p><strong>Results: </strong>ReDoVs were detected in 51.30% of the periodontitis group and 21.74% of the other groups with oral hygiene habits (<i>p</i> < 0.0001). ReDoV presence was associated with a lack of teeth-brushing habits (<i>p</i> < 0.05). Furthermore, flossing was negatively correlated with reduced ReDoV genomes (<i>r</i> = -0.20, <i>p</i> = 0.03).</p><p><strong>Conclusions: </strong>ReDoVs and periodontitis were associated with adults with poor dental hygiene. This supports a possible multifactorial and complex interaction between the presence of ReDoVs and periodontitis. Also, the findings of this study highlight that poor oral hygiene increases the likelihood of ReDoV presence and suggests that factors such as flossing are predictors of ReDoV infections.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1572274"},"PeriodicalIF":3.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of HPV and its association with oropharyngeal cancer among dental students: a systematic review and meta-analysis.","authors":"Khaled Albusairi, Badriyah Mandani, Ward Bouresly, Yash Brahmbhatt, Hend Alqaderi, Hesham Alhazmi","doi":"10.3389/froh.2025.1604925","DOIUrl":"10.3389/froh.2025.1604925","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) infection is a significant risk factor for oropharyngeal cancer (OPC), yet dental students' knowledge of this association varies widely. Given the critical role dentists play in early detection and prevention, understanding their level of knowledge is essential. This study systematically reviews existing research to assess dental students' awareness of HPV and its link to OPC.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted following PRISMA guidelines. PubMed, ProQuest, and Web of Science databases were searched for studies published up to August 2023. The Newcastle-Ottawa Scale was used to evaluate study quality. A random effects model was applied to calculate pooled prevalence with 95% confidence intervals.</p><p><strong>Results: </strong>Sixteen studies, comprising 6,345 participants, were included. The pooled analysis showed that 69% of dental students had general knowledge of HPV (range: 56%-96.5%; 95% CI: 0.56-0.81), while 77% recognized its association with OPC (range: 18%-96.4%; 95% CI: 0.63-0.89). Significant heterogeneity was observed across studies (<i>Q</i> = 646.34, <i>P</i> < 0.001 for HPV; <i>Q</i> = 804.07, <i>P</i> < 0.001 for HPV-OPC).</p><p><strong>Conclusion: </strong>Knowledge gaps among dental students may hinder prevention efforts. Standardized education in dental curricula is crucial to ensure future dentists are well-prepared to address HPV-related conditions and promote early detection in clinical practice.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1604925"},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNAs modulation by isodrimeninol from <i>Drimys winteri</i> in periodontitis-associated cellular models: preliminary results.","authors":"Nelia M Rodríguez, Pía Loren, Isis Paez, Viviana Burgos, Constanza Martínez-Cardozo, Alejandra Chaparro, Luis A Salazar","doi":"10.3389/froh.2025.1489823","DOIUrl":"10.3389/froh.2025.1489823","url":null,"abstract":"<p><strong>Introduction: </strong>Periodontitis is a chronic inflammatory disease characterized by the progressive destruction of the tooth's supporting tissues, driven by complex interactions between periodontopathogenic bacteria, environmental factors, and the host immune response. MicroRNAs (miRNAs) have emerged as key modulators of inflammatory pathways and are increasingly recognized for their role in the pathogenesis of periodontitis. Their deregulation in this disease suggests potential therapeutic applications targeting miRNA expression. Natural compounds such as isodrimeninol, derived from <i>Drimys winteri</i> (<i>Dw</i>), may offer novel approaches to modulate miRNA activity due to their antiinflammatory properties. However, no studies have previously linked this sesquiterpene to miRNA regulation in periodontitis. This study investigates the <i>in vitro</i> effects of isodrimeninol on six miRNAs (miR-17-3p, miR-21-3p, miR-21-5p, miR-146a-5p, miR-155-5p, and miR-223-3p) associated with periodontitis using two cellular models.</p><p><strong>Methods: </strong>Saos-2 cells (osteoblast-like cells) and periodontal ligament-derived mesenchymal stromal cells (hPDL-MSCs). Both cell types were stimulated with lipopolysaccharide (LPS) to induce inflammation and treated with isodrimeninol and resveratrol for comparison.</p><p><strong>Results: </strong>Isodrimeninol reduced Interleukin-1beta (IL-1β) and Interleukin-6 (IL-6) gene expression and caused differential expression patterns of the miRNAs examined, upregulating miR-146a-5p and miR-223-3p, while downregulating miR-17-3p, miR-21-3p, miR-21-5p, and miR-155-5p (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>These findings indicate a connection between miRNAs, periodontitis, and the regulation of inflammation by isodrimeninol, providing potential opportunities for the treatment. However, further validation is needed to confirm these results.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1489823"},"PeriodicalIF":3.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untreated early childhood caries is a potential disability: policy and programme implications for Africa.","authors":"Moréniké Oluwátóyìn Foláyan, Adeyinka Ganiyat Ishola, Olunike Rebecca Abodunrin, Nicaise Ndembi, Maha El Tantawi","doi":"10.3389/froh.2025.1546747","DOIUrl":"10.3389/froh.2025.1546747","url":null,"abstract":"<p><p>Early Childhood Caries (ECC) is a significant oral health condition that impacts children globally. This manuscript's main objective is to explore ECC's impact on children's oral health-related quality of life (OHRQoL) in Africa, and to highlight the policy and programme recommendations to eliminate untreated ECC as a public health threat in Africa. In Africa, ECC poses a significant public health challenge and has the potential to result in functional disabilities in children. A rapid review of the literature focusing on studies from Africa explored the impact of ECC on children's oral health-related quality of life. The three studies that met the eligibility criteria revealed that ECC negatively impacts multiple dimensions of life, including physical health (pain, malnutrition, chewing difficulties), psychological well-being (low self-esteem, stigma), and social functioning (peer relationships, school attendance). Advanced ECC had more pronounced effects, particularly in the symptom and psychological domains. The paper highlights the urgent need to recognise untreated ECC as a disability within public health frameworks in Africa. Policy recommendations include integrating oral health into primary healthcare systems, expanding community-based prevention programmes, incentivising the production of affordable oral health products, and developing school-based education initiatives. Strengthening oral health workforce capacity and enhancing data collection on ECC prevalence is critical for effective policy formulation and resource allocation. Recognising ECC as a potential disability underscores the need for a multi-sectoral approach to address this neglected public health priority and for prioritising actions to eliminate untreated ECC as the International Day of Persons with Disabilities (December 3) is marked.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1546747"},"PeriodicalIF":3.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing a naturopathic mouthwash with selective antimicrobial effects against multispecies oral biofilms for prevention of dysbiosis.","authors":"Danyal A Siddiqui, Yi-Wen C Tsai, Juliana Giron Bastidas, Marzieh S Jazaeri, Georgios A Kotsakis","doi":"10.3389/froh.2025.1529061","DOIUrl":"10.3389/froh.2025.1529061","url":null,"abstract":"<p><strong>Introduction: </strong>Oral rinses intended for the prevention and treatment of periodontal diseases have traditionally focused on bactericidal effects. This study evaluates the efficacy of a naturopathic mouthwash containing plant attenuations and propolis against common gram- pathogenic and gram+ commensal oral species in comparison to conventional antiseptic oral rinses.</p><p><strong>Methods: </strong><i>Streptoccoccus oralis, Streptococcus gordonii, Veillonella parvula, Fusobacterium nucleatum, and Porphyromonas gingivalis</i> were cultured and treated with naturopathic StellaLife® VEGA® Oral Rinse (SL), 0.12% chlorhexidine gluconate (CHX), LISTERINE® COOL MINT® mouthwash (LIS), or phosphate-buffered saline (PBS) as negative control. Firstly, planktonic bacterial growth was assessed through optical density measurements and colony-forming unit (CFU) counts. Subsequently, a 4-species or clinical ex vivo multispecies biofilm was used to evaluate antibiofilm effects through selective agar plating and fluorescence in situ hybridization (FISH) or live-dead biofilm imaging, respectively. Lastly, cytocompatibility to oral rinses was tested using a 3D human fibroblast spheroid model.</p><p><strong>Results: </strong>SL significantly inhibited the growth of disease-associated <i>F. nucleatum and P. gingivalis</i> 12 and 120 h, respectively, after treatment, while exhibiting lower toxicity toward commensal <i>S. oralis, S. gordonii</i>, and <i>V. parvula</i> vs. <i>LIS</i> or CHX (all <i>p</i> < 0.05). Correspondingly, in 4-species biofilms, selective agar plating and FISH-staining showed decreased abundance of <i>F. nucleatum and P. gingivalis</i> after 4 h recovery following SL treatment vs. PBS control while maintaining a robust commensal biofilm of <i>S. oralis and V. parvula</i>. In contrast, CHX or LIS treatment demonstrated non-selective killing, leading to sparse biofilms with residual <i>F. nucleatum and P. gingivalis</i>. When tested against clinical ex vivo multispecies biofilms, all oral rinses showed significant antibiofilm effects (all <i>p</i> < 0.001), disrupting biofilm structure and reducing bacterial viability. Lastly, 3D human fibroblast spheroids treated with CHX or LIS displayed greater cytotoxicity with detachment of cellular debris from the spheroid mass, while spheroids exposed to SL exhibited minimal cell death with cellular viability maintained across the spheroid structure.</p><p><strong>Discussion: </strong>The SL homeopathic rinse demonstrated selective action on oral bacteria, preferentially reducing pathogen bacterial load while preserving commensal species with high cytocompatibility. Future validation in human studies is needed to assess its selective antimicrobial activity to maintain a eubiotic oral microbiome and explore broader applications in oral health.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1529061"},"PeriodicalIF":3.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and reliability of a smartphone-based photographic method for detection of dental caries in adults for use in teledentistry.","authors":"Victor F Lamas-Lara, Manuel A Mattos-Vela, Teresa A Evaristo-Chiyong, Maria Eugenia Guerrero, Juan F Jiménez-Yano, Dora N Gómez-Meza","doi":"10.3389/froh.2025.1470706","DOIUrl":"10.3389/froh.2025.1470706","url":null,"abstract":"<p><strong>Introduction: </strong>With the arrival of the COVID-19 pandemic, the role of teledentistry increased its need for implementation. In this sense, the study aimed to validate a smartphone-based remote photographic method for diagnosing dental caries in adults attending a polyclinic in Lima, Peru.</p><p><strong>Methods: </strong>A cross-sectional, descriptive research was conducted; 87 patients were selected, and 2020 teeth were evaluated. Each participant underwent a clinical diagnosis of dental caries by two trained and calibrated dentists, considering the diagnostic criteria of the WHO; during the same visit, after the clinical examination, a family member of the patient was instructed to take a photographic record with a cell phone, through a video. Five photographs of the dental arches were recorded, where the centering of images, resolution, and visualization of all the teeth were evaluated. The photographic evaluation was performed by two independent evaluators blinded to the visual evaluation performed, following the same criteria as the clinical visual evaluation. For the data analysis, Cohen's kappa index was determined for interexaminer reliability; sensitivity, specificity, and positive and negative predictive values were obtained.</p><p><strong>Results: </strong>Overall, high sensitivity: 90.19% [Interquartile 95% (CI): 88.23-92.16]; and specificity: 95.15% (95% CI: 93.83-96.47). The interexaminer agreement was almost perfect, with a kappa of 0.935 and 0.974 for clinical and photographic evaluation, respectively.</p><p><strong>Conclusions: </strong>It is concluded that the photographic method using a smartphone has demonstrated a satisfactory level of caries detection in adults.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1470706"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system: a randomized placebo-controlled clinical trial.","authors":"Kiarash Zare, Mahva Talaei, Amir Hesam Pahlevani, Fahimeh Rezazadeh, Kiana Zare, Masumeh Akbaryari, Mohammad Mehdi Naghizadeh, Mojtaba Heydari, Mohsen Goharinia","doi":"10.3389/froh.2025.1470531","DOIUrl":"10.3389/froh.2025.1470531","url":null,"abstract":"<p><strong>Background: </strong>This randomized placebo-controlled clinical trial aimed to evaluate the effect of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system.</p><p><strong>Methods: </strong>Eighty healthy individuals were randomly assigned to four groups: oral caffeine capsules (100 mg caffeine) as the control, brushing with caffeinated toothpaste (100 mg caffeine) for 2, 3, and 4 min. Cognitive and motor responses were assessed using selective processing speed assessment (Stroop test), short-term memory test, selective attention capacity assessment, and hand-eye coordination test before and after intervention at 10, 30, and 60 min intervals.</p><p><strong>Results: </strong>Brushing with caffeinated toothpaste was as effective as oral caffeine intake in improving selective attention capacity, selective processing speed, short-term memory, and hand-eye coordination. Despite the higher improvement in the longest duration brushing group in most of the outcomes, the difference did not reach the statistical significance among study groups.</p><p><strong>Conclusion: </strong>Brushing with caffeinated toothpaste appears to be as effective as oral intake of caffeine in enhance cognitive and motor functions.</p><p><strong>Clinical trial registration: </strong>https://irct.behdasht.gov.ir/trial/71213, identifier (IRCT20230318057752N2).</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1470531"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positional and dimensional osseous characteristics of the temporomandibular joint in female patients with skeletal class III malocclusion and disc displacement, with and without reduction.","authors":"Abeer A Almashraqi, Amira A Aboalnaga, Maged S Alhammadi, Mona M Salah Fayed","doi":"10.3389/froh.2025.1572305","DOIUrl":"10.3389/froh.2025.1572305","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to compare the dimensional and positional osseous features of the temporomandibular joint (TMJ) in patients with skeletal Class III malocclusion, female patients without temporomandibular disorders (TMDs), and those with TMDs presenting as disc displacement with/without reduction (DDR/DDWR).</p><p><strong>Methods: </strong>Adult patients with skeletal Class III malocclusion and average vertical facial pattern (Mandibular plane inclination = 37 ± 5°) were categorized into the TMD group comprising patients with DDR/DDWR and the non-TMD group. Three-dimensional standardized TMJ analysis was performed using cone-beam computed tomography, which included assessments of the mandibular fossa (MF), mandibular condyle, TMJ spaces, and vertical and anteroposterior intra-joint condylar positions.</p><p><strong>Results: </strong>The MF location in the DDR/DDWR group was significantly more superior (<i>p</i> < 0.0001) and anterior (<i>p</i> = 0.012) relative to the respective planes. The MF width was significantly lesser (<i>p</i> = 0.001) with a steeper (<i>p</i> < 0.0001) anterior wall inclination in the DDR/DDWR group than in the non-TMD. The mandibular condyles were located significantly more laterally (<i>p</i> = 0.016), at a greater distance from the midsagittal plane, in the DDR/DDWR group than in the non-TMD. The anterior and medial joint spaces were significantly larger (<i>p</i> < 0.0001) and the intra-joint condylar positions were more posterior and superior (<i>p</i> < 0.0001) in the DDR/DDWR group than in the non-TMD.</p><p><strong>Conclusions: </strong>The positional and dimensional osseous characteristics of the TMJ differed significantly between patients with skeletal Class III malocclusion without TMDs and those with DDR or DDWR.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1572305"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study on the impact of different antibiotic regimens in non-surgical periodontal therapy on microbial loads and therapy outcomes.","authors":"Nils Werner, Vinay Pitchika, Katrin Heck, Christina Ern, Richard Heym, Ali Al-Ahmad, Fabian Cieplik, Falk Schwendicke, Caspar Victor Bumm, Matthias Folwaczny","doi":"10.3389/froh.2025.1578484","DOIUrl":"10.3389/froh.2025.1578484","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to analyse the impact of different antibiotic regimens during non-surgical periodontal therapy on the microbial load of selected periodontitis-associated bacteria (PAB) and the primary therapy outcomes.</p><p><strong>Methods: </strong>For this aim, 259 patients received steps I and II of periodontal therapy and were included in this clinical trial. 202 patients were treated without the adjunctive use of systemic antibiotics, 18 received amoxicillin (AMOX) as well as metronidazole (MET) and 39 only MET. Subgingival biofilm samples were quantitatively analysed for selected PAB using DNA-DNA-hybridisation-based detection assays for microbial loads of PAB before and 6 months after treatment. Changes in the microbial load of PAB and achievement of a \"treat-to-target\" endpoint (T2T) (≤4 sites with probing depth ≥5 mm) were analysed. Patients' subgingival microbial load was significantly reduced following therapy.</p><p><strong>Results: </strong>38.2% of the patients achieved T2T. Binary logistic regression adjusted for confounders indicated a relationship between residual PAB levels and not achieving T2T. In patients not receiving systemic antibiotics a 2.4-fold increased risk of not reaching T2T after steps I and II therapy was observed (none vs. MET aOR = 2.38 <i>p</i> = 0.44). Linear regression analysis adjusted for T0 PAB concentration and confounders revealed an increased reduction of PAB levels in patients with systemic antibiotics. No difference in PAB reduction or chance of achieving T2T was observed between MET and MET + AMOX.</p><p><strong>Discussion: </strong>Microbial loads of PAB were found directly associated with periodontal status. As antibiotic treatment with both MET and MET + AMOX similarly reduced microbial loads of PAB, treatment with MET alone may be sufficiently effective as adjunctive to non-surgical periodontal treatment. To confirm this, further prospective studies with bigger sample size are needed.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1578484"},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of artificial intelligence in periodontal treatment maintenance: a scoping review.","authors":"Raafat Musief Sarakbi, Sudhir Rama Varma, Lovely Muthiah Annamma, Vinay Sivaswamy","doi":"10.3389/froh.2025.1561128","DOIUrl":"10.3389/froh.2025.1561128","url":null,"abstract":"<p><p>Gingivitis and periodontitis, are widespread conditions with diverse influence on oral and systemic health. Traditional diagnostic methods in periodontology often rely on subjective clinical assessments, which can lead to variability and inconsistencies in care. Imbibing artificial intelligence (AI) facilitates a significant solution by enhancing precision metrics, treatment planning, and personalized care. Studies published between 2018 and 2024 was conducted to evaluate AI applications in periodontal maintenance. Databases such as PubMed, Cochrane, Web of Science and Scopus were searched using keywords like \"artificial intelligence,\" \"machine learning,\" and \"periodontitis.\" Studies employing AI for diagnosis, prognosis, or periodontal maintenance using clinical or radiographic data were included. Deep learning algorithms such as convolutional neural networks (CNNs) and segmentation techniques were analyzed for their diagnostic accuracy. AI demonstrated superior performance in detecting periodontal conditions, with accuracy rates surpassing 90% in some studies. Advanced models, such as Multi-Label U-Net, exhibited high precision in radiographic analyses, outperforming traditional methods. Additionally, AI facilitated predictive analytics for disease progression and personalized treatment strategies. AI has transformed periodontal care, offering accuracy, personalized care, and efficient workflow integration. Addressing challenges like standardization and ethical concerns is critical for its broader adoption.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1561128"},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}