Frontiers in oral health最新文献

{"title":"Artificial intelligence-driven clinical decision support systems for early detection and precision therapy in oral cancer: a mini review.","authors":"Manoj Kumar Karuppan Perumal, Remya Rajan Renuka, Suresh Kumar Subbiah, Prabhu Manickam Natarajan","doi":"10.3389/froh.2025.1592428","DOIUrl":"https://doi.org/10.3389/froh.2025.1592428","url":null,"abstract":"<p><p>Oral cancer (OC) is a significant global health burden, with life-saving improvements in survival and outcomes being dependent on early diagnosis and precise treatment planning. However, diagnosis and treatment planning are predicated on the synthesis of complicated information derived from clinical assessment, imaging, histopathology and patient histories. Artificial intelligence-based clinical decision support systems (AI-CDSS) provides a viable solution that can be implemented via advanced methodologies for data analysis, and synthesis for better diagnostic and prognostic evaluation. This review presents AI-CDSS as a promising solution through advanced methodologies for comprehensive data analysis. In addition, it examines current implementations of AI-CDSS that facilitate early OC detection, precise staging, and personalized treatment planning by processing multimodal patient information through machine learning, computer vision, and natural language processing. These systems effectively interpret clinical results, identify critical disease patterns (including clinical stage, site, tumor dimensions, histopathologic grading, and molecular profiles), and construct comprehensive patient profiles. This comprehensive AI-CDSS approach allows for early cancer detection, a reduction in diagnostic delays and improved intervention outcomes. Moreover, the AI-CDSS also optimizes treatment plans on the basis of unique patient parameters, tumor stages and risk factors, providing personalized therapy.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1592428"},"PeriodicalIF":3.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis.","authors":"Tribikram Debata, Amrita Swain, Soumya Ranjan Jena, Surya Narayan Das, Niranjan Mishra, Luna Samanta","doi":"10.3389/froh.2025.1550683","DOIUrl":"https://doi.org/10.3389/froh.2025.1550683","url":null,"abstract":"<p><strong>Background: </strong>The association between Vitamin D Receptor (VDR) polymorphisms and different cancers has attracted growing attention; nonetheless, the function of these genetic variants in tobacco-related oral cancer remains little comprehended. This review assesses and integrates research concerning the influence of VDR gene variants on the development of tobacco-related oral cancer, emphasizing genetic underpinnings of individual vulnerability and possible tailored preventative approaches.</p><p><strong>Materials and methods: </strong>The search strategy for this systematic review and meta-analysis was devised to comprehensively identify relevant studies from diverse sources. The investigation included three primary components: the VDR gene, oral cancer, and tobacco. The data from the papers included in the study were independently retrieved by two reviewers. The incidence was evaluated as an odds ratio (OR) with 95% confidence interval (95% CI) using SPSS software.</p><p><strong>Results: </strong>A preliminary search of biomedical electronic research databases (PubMed, Web of Science, Scopus, Embase, and the Cochrane Library) yielded 60,345 papers. After multi-phase exclusions, five studies met the inclusion criteria. The meta-analysis highlights interactions between genetic polymorphisms, smoking, aging, and oral health risks. The CYP24A1 (rs2296241) heterozygote genotype significantly reduces oral cancer risk (OR = 0.281, <i>P</i> = 0.00001). Variants rs1544410 and rs2228570 influence oral health outcomes. The rs2239185 TT (OR = 2.68, <i>P</i> = 0.009) and rs7975232 CC (OR = 2.25, <i>P</i> = 0.026) increase oral lichen planus risk. Older age is significantly linked to OSCC risk (<i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>This research underscores the role of VDR gene variants in tobacco-related oral cancer. Further studies are essential to validate findings and explore underlying mechanisms.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024587292, identifier: CRD42024587292.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1550683"},"PeriodicalIF":3.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hybrid approach to predicting and classifying dental impaction: integrating regularized regression and XG boost methods.","authors":"Asok Mathew, Pradeep K Yadalam, Ahmed Radeideh, Shorouq Hadi, Rona Swed, Reyyan Cheema, Majd Mousa Al-Mohammad, Mohammed Alsaegh, S R Shetty","doi":"10.3389/froh.2025.1524206","DOIUrl":"10.3389/froh.2025.1524206","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Dental impaction is a significant clinical challenge that requires advanced predictive modeling and healthcare analytics approaches. Impaction, a tooth alignment issue, is diagnosed using radiographic measurements like panoramic radiographs and CBCT. Artificial Intelligence (AI) is improving the accuracy of predicting dental impaction. Advanced predictive models like logistic Regression and XGBoost analyze critical variables, identify patterns, and perform predictive analysis. These models can identify potential impactions, assess impaction type, and develop treatment plans. Integrating AI into radiographic assessments is expected to enhance further the precision and risk-minimizing capabilities of surgical planning in dentistry. This study presents a hybrid approach combining regularized regression and ensemble methods to enhance the classification and prediction of dental impaction outcomes. By leveraging machine learning and statistical learning techniques, we aim to develop a robust clinical decision support system for dental practitioners.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This research aims to predict the eruption of 3rd molars in the mandible by analyzing three parameters: the distance from the lower 2nd molar to the anterior border, the mesiodistal width of the third molar, and the distance from the apex of the root to the inferior border of the mandible. The study is quantitative, observational, and cross-sectional retrospective. The distance from the lower 2nd molar to the anterior border determines the importance of space available for eruption. The distance from the root apex to the lower border addresses natural eruptive forces and resistance during the eruption. The study aims to find a correlation between eruption and distance from the root apex to the lower border of the mandible. Our feature selection process utilizes ensemble learning algorithms integrated with regularized regression techniques to analyze various parameters. This data analysis framework combines multiple predictive modeling approaches to achieve optimal results.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The horizontal type of impaction has the lowest S/W ratio (0.9267), indicating the least available distal to 2nd molar space. This suggests a low potential for future eruptions. The regression equation calculates the S/W ratio using impacted molar width and distal space. A ratio greater than 1.1 indicates a good probability of lower 3rd molar eruption, while a below 0.8 indicates no eruption. The algorithm development process demonstrated the effectiveness of our hybrid approach in dental health analytics. The study improved impaction prediction accuracy to a rate of 78%, with horizontal class predictions achieving a precision of 0.72 and an error rate of 28.1%. Additionally, the regularized logistic regression model attained 75% accuracy for classification and prediction.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The study aims to improve dental r","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1524206"},"PeriodicalIF":3.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Exploring oral microbiota dysbiosis as a risk factor for oral and non-communicable diseases.","authors":"Denis Bourgeois, Giovanna Orsini, Florence Carrouel","doi":"10.3389/froh.2025.1611120","DOIUrl":"https://doi.org/10.3389/froh.2025.1611120","url":null,"abstract":"","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1611120"},"PeriodicalIF":3.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association of calbindin -D28K in renal dialysis with oral health: a comprehensive review.","authors":"Mohamed Jaber, Mohamed Saleh Hamad Ingafou, Nireeksha, Alexander Maniangat Luke","doi":"10.3389/froh.2025.1523024","DOIUrl":"https://doi.org/10.3389/froh.2025.1523024","url":null,"abstract":"<p><strong>Background: </strong>The kidney, brain, and endocrine glands all express calbindin-D28K, a calcium-binding protein that is essential for maintaining calcium homeostasis. Calcium metabolism is disturbed in chronic kidney disease (CKD), which may have an impact on dental and bone health. Patients on dialysis frequently have changed salivary composition, which raises their risk of dental problems such tooth decay and periodontal disease. Although there is no direct study on the relationship between Calbindin-D28K and dental health in dialysis patients, its function in calcium control raises the possibility of a connection that merits more investigation.</p><p><strong>Objective: </strong>To address the impact of Calbindin-D28K levels in chronic kidney disease on oral health.</p><p><strong>Design: </strong>A comprehensive electronic search was conducted using databases like PubMed, ResearchGate, SCOPUS, and others, to find relevant articles published before May 2024. The search terms included Calbindin-D28K, renal dialysis, dental and oral health, Vitamin D, calcium, end-stage renal disease, and related topics. The review examined studies from 1975 to 2024, focusing on the relationship between dental health and renal dialysis and factors affecting Calbindin-D28K levels.</p><p><strong>Results: </strong>A total of 48 articles were retrieved through electronic database. After evaluating the title, abstract, and full text of these articles, only 7 were selected for the present review. Final consideration: Based on the data available on selected studies, they point to a possible association between these people's higher frequency of periodontal disease and tooth caries and lower levels of Calbindin-D28K.It is imperative to recognize the reciprocal impact of systemic illnesses on oral health. In addition to being important for maintaining calcium homeostasis, calbindin-D28K may also be a biomarker for renal damage and have an impact on dental health. Its relevance for both diagnosis and treatment of chronic kidney disease and associated diseases is highlighted by its involvement in renal function and neuroprotection.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1523024"},"PeriodicalIF":3.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From cultural dispositions to biological dimensions: a narrative review on the synergy between oral health and vitamin D through the lens of Indian habitus.","authors":"Sumit Maitra, Hari Charan Behera, Arkopala Bose, Diptendu Chatterjee, Arup Ratan Bandyopadhyay","doi":"10.3389/froh.2025.1569940","DOIUrl":"https://doi.org/10.3389/froh.2025.1569940","url":null,"abstract":"<p><p>Oral health is intricately related to systemic health, with new worldwide research demonstrating vitamin D's critical role in sustaining dental and periodontal health. Vitamin D regulates calcium and phosphate metabolism, which is required for the formation and maintenance of healthy teeth and bones. According to research, vitamin D deficiency may contribute to the etiology of periodontal disease by decreasing the host immune response, making it more susceptible to infections like gingivitis and periodontitis. Oral health in India is a tapestry of traditional practices, socioeconomic factors, lifestyle factors, and access to modern healthcare, all of which are intricately linked with the concept of habitus, which refers to deeply embedded habits, dispositions, and practices shaped by an individual's social space. Deep-rooted social and cultural influences have a substantial impact on oral hygiene practices, food patterns, and health-seeking behaviours. Oral diseases are considered as a worldwide health issue. Though standard Western medicine has had effectiveness in preventing and treating periodontal diseases and other oral disorders, the hunt for alternative solutions continues, and natural phytochemicals extracted from plants used in traditional medicine are regarded as viable alternatives to synthetic chemicals. India's traditional medical knowledge and practice, take a comprehensive approach to oral health, emphasizing the balance of physiological components and the use of natural treatments to maintain oral hygiene and treat oral disorders. However, the structural integrity of teeth and optimal oral health can be accomplished by combining Indian traditional medical practices with vitamin D supplementation, which has synergistic attributes for gum health, anti-inflammatory effects, and dental caries prevention. Nevertheless, the unique association of oral health, vitamin D deficiency and the habitus from Indian perspective is extremely underrepresented in academia. To the best of our knowledge, in the aforementioned context, the present narrative review is probably the maiden attempt to discern the crosstalk of oral health and Vitamin D from the perspectives of Indian habitus.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1569940"},"PeriodicalIF":3.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating factors associated with alcohol intake and periodontal condition.","authors":"Yuto Kusu, Michiko Furuta, Shinya Kageyama, Yoshihisa Yamashita, Toru Takeshita","doi":"10.3389/froh.2025.1524772","DOIUrl":"https://doi.org/10.3389/froh.2025.1524772","url":null,"abstract":"<p><strong>Background: </strong>Alcohol consumption has been reported to increase the risk of periodontal disease and various health abnormalities such as obesity, hyperglycemia, and liver abnormalities. While the link between these health abnormalities and periodontal disease has been established, their potential mediating role in the association between alcohol consumption and periodontal disease remains unclear. Therefore, this study aims to investigate the multiple mediating roles of obesity, hyperglycemia, and liver abnormalities in this association.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 6,529 individuals aged 35-64 years who underwent workplace health check-ups in 2003 (mean age: 45.7 ± 8.7 years). The periodontal condition was evaluated using the mean pocket depth (PD), and participants were classified into no, light/moderate (alcohol consumption 0.1-29.9 g/day), and heavy (≥30 g/day) drinking groups. Causal mediation analysis was performed.</p><p><strong>Results: </strong>Heavy drinking had a direct effect on the mean PD. Light/moderate drinking had a indirect effect on the mean PD through the body mass index (BMI), glucose level, alanine aminotransferase level (ALT), with proportion mediated of 25.1%, 8.9%, and 18.9%, respectively. The mediating role of glucose level was found in the association between heavy drinking and the mean PD with proportion mediated of 32.7%.</p><p><strong>Conclusion: </strong>This study confirmed that alcohol consumption was associated with worse periodontal condition among Japanese adults who received workplace health check-ups. This association was partially contributed by several factors such as BMI, glucose level, and ALT.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1524772"},"PeriodicalIF":3.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth loss and mortality risk: the mediating role of hs-CRP in a Chinese cohort.","authors":"Donglei Wu, Mingxin Mao, Wei Wang, Henan Zheng, Hongxia You, Weixuan Chen, Ziyang Xu, Yuyan Zheng, Li Yuan","doi":"10.3389/froh.2025.1542147","DOIUrl":"https://doi.org/10.3389/froh.2025.1542147","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the mediating effect of systemic condition on the relationship between tooth loss and mortality risk.</p><p><strong>Materials and methods: </strong>A 9-y follow-up prospective longitudinal study was conducted based on China Health and Retirement Longitudinal Study (CHARLS). The participants aged >45 y at baseline and were followed up from 2011 to 2020. Cox proportional hazards models were utilized to assess the relationship between tooth loss and both all-cause mortality with hazard ratios (HRs) and 95% confidence intervals (CIs) reported with adjusted possible confounders. Systemic inflammation markers, including high-sensitivity C-reactive protein (hs-CRP) and white blood cell count (WBCs), were collected from CHARLS blood sample data. A mediation analysis was conducted to determine the role of hs-CRP and WBCs in the relationship between tooth loss and mortality.</p><p><strong>Results: </strong>A total of 13,201 participants met the inclusion criteria, of which 964 had tooth loss and 12,237 did not. During a median follow-up of 8.7 years, The multivariable-adjusted Cox regression models. The subgroup analysis indicated that the association was found to be stronger among older adults (≥80 years) (HR: 1.62, 95% CI: 1.09-2.41) and males (HR: 1.80, 95% CI: 1.34-2.40). Additionally, the mediation analysis result has showed that serum hs-CRP level rather WBC count mediated 3% of this effect.</p><p><strong>Conclusions: </strong>Complete tooth loss is associated with higher mortality in the Chinese population, with systemic inflammation (hs-CRP) as a mediator.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1542147"},"PeriodicalIF":3.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Literature review of the portrayal of dentists and teeth in movies.","authors":"Andy Wai Kan Yeung","doi":"10.3389/froh.2025.1584382","DOIUrl":"https://doi.org/10.3389/froh.2025.1584382","url":null,"abstract":"<p><strong>Introduction: </strong>There are multiple portrayals of dentists and teeth in movies. It is largely unclear if the literature has investigated these portrayals. This literature review aimed to identify and analyze the themes, narratives, and symbolic meanings associated with dental portrayal in movies from the existing literature.</p><p><strong>Methods: </strong>Online literature databases, Web of Science, Scopus, and PubMed, were searched to identify relevant papers labelled as articles or reviews. Publications were included if they described or investigated the portrayal of dentists or teeth in multiple commercial movies. Publications were excluded if they were irrelevant to this topic or provided commentary on a single movie only. Finally, 7 publications were identified and reviewed. For each publication, its study design, data source, and genres of movies analyzed were recorded. Key findings were reviewed, such as themes or stereotypes identified, positive vs. negative portrayals, and any impact on public perception elaborated.</p><p><strong>Results: </strong>These papers were published between 2007 and 2024. Five of them provided qualitative content analysis, whereas 2 provided quantitative content analysis. Three publications consulted Internet Movie Database (IMDb) to identify relevant movies. Many of the publications did not explicitly report very detailed inclusion and exclusion criteria for the selection of movies. The portrayal of dentists was covered in 5 publications. The symbolic meaning of teeth was covered in 2 publications. (One publication covered both dentist portrayal and teeth symbolism.) Scenes of oral hygiene practice were investigated in 1 publication.</p><p><strong>Conclusion: </strong>The portrayal of dentists in movies has often been negative, which may influence public perception and contribute to dental anxiety. Future research should investigate the impact of these portrayals on audience attitudes and behavior, as this review underscores the need for more empirical studies in this area. Meanwhile, readers should notice that one major limitation of this review is the small number of publications included.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1584382"},"PeriodicalIF":3.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The calcified Sphenomandibular ligament: case report, surgical management and literature review.","authors":"Shareef Araidy, George Batshon, Roman Mirochnik, Imad Abu El-Naaj","doi":"10.3389/froh.2025.1581583","DOIUrl":"https://doi.org/10.3389/froh.2025.1581583","url":null,"abstract":"<p><p>Calcification of the Sphenomandibular ligament (SML) is an extremely rare condition, with only three previously documented cases worldwide. This report presents the fourth known case of SML calcification in a 32-year-old male patient with a 17-year history of progressive trismus. Following a dental procedure involving a mandibular nerve block, the patient gradually developed limited mouth opening, which was resistant to conservative treatments. Imaging revealed calcification of the SML, which was confirmed intraoperatively. Surgical excision led to a significant improvement in mandibular function. This report discusses clinical presentation, diagnostic workup, surgical management, and a comprehensive literature review, emphasizing the importance of considering rare ligamentous pathologies in cases of persistent trismus.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1581583"},"PeriodicalIF":3.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}