Efficacy of oral metronomic chemotherapy in the management of head and neck squamous cell carcinoma-a systematic review.

IF 3.1 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Frontiers in oral health Pub Date : 2025-07-30 eCollection Date: 2025-01-01 DOI:10.3389/froh.2025.1632316

Aardra Binithadas Segin Chandran, Deepak Pandiar, Reshma Poothakulath Krishnan, Divya Gopinath

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Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is a group of heterogeneous malignancies and constitutes one of the most prevalent forms of cancer. Oral metronomic chemotherapy (OMCT) is a treatment in which low doses of anticancer drugs are given at regular intervals over a long time, with many advantages over conventional therapies, particularly in nations with high cancer burden. The present systematic review aimed to evaluate the efficacy of OMCT in the management of HNSCC in comparison to other standard chemotherapy regimens. Methodology: The review was registered in the Prospero database (CRD42023426000). An electronic search was conducted using PubMed, Scopus, Web of Science and Google Scholar databases. Articles in which OMCT was used to treat HNSCC were included for systematic review, and the survival and response rates were analyzed.

Results: Twenty-four eligible articles were included for evaluation, which revealed that administration of OMCT produced higher survival and response rates in subjects compared to standard chemotherapy.

Conclusion: The evidence from the included studies supports that oral metronomic chemotherapy is substantially more effective as compared to standard chemotherapy regimens in squamous cell carcinomas of the head and neck.

Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42023426000, identifier (CRD42023426000).

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口服节律化疗治疗头颈部鳞状细胞癌疗效的系统评价。

背景：头颈部鳞状细胞癌（HNSCC）是一组异质性恶性肿瘤，是最常见的癌症之一。口服节律化疗（OMCT）是一种长期定期给予低剂量抗癌药物的治疗方法，与传统疗法相比具有许多优势，特别是在癌症负担高的国家。本系统综述旨在评价与其他标准化疗方案相比，OMCT治疗HNSCC的疗效。方法：该综述已在Prospero数据库中注册（CRD42023426000）。利用PubMed、Scopus、Web of Science和b谷歌Scholar数据库进行电子检索。纳入使用OMCT治疗HNSCC的文章进行系统评价，并分析生存率和有效率。结果：24篇符合条件的文章被纳入评估，这些文章显示，与标准化疗相比，OMCT治疗在受试者中产生了更高的生存率和有效率。结论：纳入研究的证据支持口服节律化疗与标准化疗方案相比在头颈部鳞状细胞癌中更有效。系统评价注册：https://www.crd.york.ac.uk/PROSPERO/view/CRD42023426000，标识符（CRD42023426000）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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