Frontiers in oral health最新文献

{"title":"Pacific oral health: a scoping review.","authors":"Naailah Zahraa Hanif, Zac Morse, Jonathan Broadbent, Anumala Ram","doi":"10.3389/froh.2025.1474623","DOIUrl":"https://doi.org/10.3389/froh.2025.1474623","url":null,"abstract":"<p><strong>Introduction: </strong>A growing body of literature reports on the oral health of Pacific peoples but a synthesis of the existing knowledge on Pacific oral health epidemiology is absent. This scoping review aims to summarise the evidence on Pacific oral health epidemiology. The findings of this review may help identify knowledge gaps and issues requiring health policy prioritisation.</p><p><strong>Methods: </strong>The review followed the PRISMA-ScR guidelines for scoping reviews and included reports published prior to July 2023 on Pacific oral health, regardless of design. Searches were conducted across four databases, and the grey literature.</p><p><strong>Results: </strong>An analysis of 95 sources, primarily from 2000 to 2023 and predominantly New Zealand-based, found that a high proportion of Pacific peoples (including children) were affected by poor oral health and challenges in accessing dental care services. Numerous studies have reported oral health disparities, with poorer oral health among Pacific peoples than other population groups. Epidemiological and health services data from Pacific Island nations show a high prevalence of dental conditions, along with limited healthcare resources and workforce shortages. Studies on the broader social determinants shaping these issues and health promotion strategies to address them were limited.</p><p><strong>Conclusion: </strong>This review revealed significant unmet oral health needs, ethnic disparities in oral health, and barriers preventing care in Pacific populations. The findings emphasise the need for more research to address these gaps to help develop effective, culturally-informed oral health strategies for Pacific communities.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1474623"},"PeriodicalIF":3.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of IL-33 and ST2 expression in head and neck squamous cell carcinoma: a systematic review.","authors":"Swetha Acharya, Usha Hegde, Anirudh Balakrishna Acharya, SubbaRao V Madhunapantula, Huchanahalli Sheshanna Sreeshyla, Priyanka Nitin, Medha Karnik","doi":"10.3389/froh.2025.1551781","DOIUrl":"10.3389/froh.2025.1551781","url":null,"abstract":"<p><strong>Background: </strong>Interleukin-33 (IL-33) and Suppression of tumorigenicity 2 (ST2) expression are strongly associated with tumor growth and progression in diverse cancers, indicating the possibility of targeting the IL-33/ST2 axis pathway as a favorable therapeutic approach. However, the specific implications of IL-33/ST2 expression in Head and Neck Squamous Cell Carcinoma (HNSCC) prognosis are not fully understood. Thus, there is a need for more comprehensive research to verify the tasks and clinical significance of IL-33 and ST2 in HNSCC.</p><p><strong>Objectives: </strong>The objective of this study was to evaluate the potential of differentially expressed IL-33 and ST2 in tumor tissues that could serve as novel biomarkers in HNSCC.</p><p><strong>Material & methods: </strong>The Web of Science, Scopus, and PubMed electronic databases were searched and analyzed from January 2013 to July 2023.</p><p><strong>Results: </strong>Nine studies fulfilling the inclusion criteria were analyzed. These selected studies were mainly having observational analytical study design, predominantly conducted within the Southeast Asian population. IL-33, primarily located in the stroma, demonstrates enhanced expression within carcinoma-associated fibroblasts (CAFs). Overexpression of IL-33 in CAFs correlates with its expression in tumor cells, as per some of these reports. Elevated IL-33 levels in CAFs are associated with unfavorable clinical outcomes. Increased IL-33 expression is related to poor nodal metastasis-free survival, indicating an adverse prognosis in HNSCC. In HNSCC, tumor cells and regulatory T cells (Tregs) expressed ST2. The degree of ST2 expression on Tregs corresponds to the abundance of IL-33 expressing CAFs. IL-33 increases the Tregs density and amplifies their suppressive capability. Poorer survival outcomes in HNSCC are linked to elevated ST2 expression in Tregs combined with the existence of IL-33-expressing CAFs.</p><p><strong>Conclusion: </strong>CAF-driven cancer invasiveness relies on IL-33 signaling via paracrine and autocrine pathways. IL-33 may be a prognostic biomarker and therapeutic target, aiming to improve prognosis and survival in HNSCC. The IL-33/ST2 axis significantly configures the tumor microenvironment and tumor aggressiveness in HNSCC. The role of serum IL33 and ST2 remains to be further studied in HNSCC.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/i, identifier (CRD42023447963).</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1551781"},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health knowledge, attitudes, behaviours and status among international post-secondary students: a scoping review.","authors":"Hassan W Yassin, Shahzaib Fida, Khrisha Alphonsus, Jessica Lieffers, Amrinderbir Singh","doi":"10.3389/froh.2025.1555165","DOIUrl":"10.3389/froh.2025.1555165","url":null,"abstract":"<p><strong>Objective: </strong>This scoping review aims to review and synthesize existing literature on oral health knowledge, attitudes, behaviours, barriers, and status among international post-secondary students.</p><p><strong>Methods: </strong>Using the Arksey and O'Malley framework, MEDLINE, Embase, Dentistry & Oral Sciences Source, CINAHL, Web of Science, and Scopus databases were searched in June 2024 for selected oral health and international student keywords. Manual searches of reference lists and citations were also conducted. Original research studies in English language were included, with no geographical or date limitations. Using Rayyan, duplicates were removed, and then two authors independently screened available literature according to eligibility criteria; inconsistencies or disagreements were resolved through a third author.</p><p><strong>Results: </strong>The search yielded 984 articles. After removal of duplicates and those inconsistent with our inclusion criteria, 14 articles remained. In total, 13/14 articles used a cross-sectional design implementing surveys or interviews; only 4 articles presented objective clinical measures (e.g., DMFT, objective periodontal measures). Some included articles provided information about dietary habits relevant to oral health; however, information captured was limited. Overall, compared to the domestic students, international students were reported to have poorer oral health status; more gaps in their knowledge, attitudes and behaviours regarding oral health; and were also less likely to obtain routine oral health care.</p><p><strong>Conclusion: </strong>International students may face significant challenges in managing and optimizing their oral health vs. domestic students due to various factors (e.g., acculturation stress, finances, diet, academic stress etc.). Post-secondary institutions may want to consider focusing on supporting and empowering international students to access oral health care on a regular basis through targeted interventions. To design impactful interventions, future community engaged research is needed to better understand the perspectives of international students regarding their oral health status, knowledge, attitudes, behaviours, needs, and aspirations.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1555165"},"PeriodicalIF":3.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Co-designing and evaluating oral health promotion interventions for vulnerable groups.","authors":"Vanessa Muirhead, Maha El Tantawi, Andrea Rodriguez","doi":"10.3389/froh.2025.1587771","DOIUrl":"10.3389/froh.2025.1587771","url":null,"abstract":"","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1587771"},"PeriodicalIF":3.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-based diagnosis of oral leukoplakia using deep convolutional neural networks Xception and MobileNet-v2.","authors":"Elakya Ramesh, Anuradha Ganesan, Krithika Chandrasekar Lakshmi, Prabhu Manickam Natarajan","doi":"10.3389/froh.2025.1414524","DOIUrl":"10.3389/froh.2025.1414524","url":null,"abstract":"<p><strong>Objective: </strong>The present study aims to employ and compare the artificial intelligence (AI) convolutional neural networks (CNN) Xception and MobileNet-v2 for the diagnosis of Oral leukoplakia (OL) and to differentiate its clinical types from other white lesions of the oral cavity.</p><p><strong>Materials and methods: </strong>Clinical photographs of oral leukoplakia and non-oral leukoplakia lesions were gathered from the SRM Dental College archives. An aggregate of 659 clinical photos, based on convenience sampling were included from the archive in the dataset. Around 202 pictures were of oral leukoplakia while 457 were other white lesions. Lesions considered in the differential diagnosis of oral leukoplakia like frictional keratosis, oral candidiasis, oral lichen planus, lichenoid reactions, mucosal burns, pouch keratosis, and oral carcinoma were included under the other white lesions subset. A total of 261 images constituting the test sample, were arbitrarily selected from the collected dataset, whilst the remaining images served as training and validation datasets. The training dataset were engaged in data augmentation to enhance the quantity and variation. Performance metrics of accuracy, precision, recall, and f1_score were incorporated for the CNN model.</p><p><strong>Results: </strong>CNN models both Xception and MobileNetV2 were able to diagnose OL and other white lesions using photographs. In terms of F1-score and overall accuracy, the MobilenetV2 model performed noticeably better than the other model.</p><p><strong>Conclusion: </strong>We demonstrate that CNN models are capable of 89%-92% accuracy and can be best used to discern OL and its clinical types from other white lesions of the oral cavity.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1414524"},"PeriodicalIF":3.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Digitally driven tooth autotransplantation using surgical templates and three-dimensional printed donor tooth replica.","authors":"Iuliana Babiuc, Marius Ștefan Diaconeasa, Viorel Ștefan Perieanu, Mădălina Adriana Malița, Irina Adriana Beuran, Mihai Burlibașa","doi":"10.3389/froh.2025.1537468","DOIUrl":"10.3389/froh.2025.1537468","url":null,"abstract":"<p><p>Tooth autotransplantation is a procedure involving the surgical repositioning of a tooth or dental germ from one site in the mouth to another within the same individual. A successful procedure requires a donor tooth with healthy cementum and periodontium, gentle surgical maneuvers, a well-fitted neoalveolus, and a short extraalveolar time of the donor tooth. Digital technology increases the accuracy and predictability of the tooth autotransplantation procedure. Surgical templates generate a more precise neoalveolus, with good stability of the donor tooth, and decrease the surgical time. Using a donor tooth replica ensures an optimal morphology of the new alveolus, thus reducing the injury of the root and the extraoral time of the donor tooth. This case report presents the tooth autotransplantation technique, that was employed to reposition a maxillary premolar with two fused roots on a mandibular recipient site. Digital planning, two surgical guides (one for each root), and a 3D printed tooth replica were used to ensure good accuracy, prognosis, and reduced treatment time. The procedure is conservative and offers considerable advantages to the patient, such as retaining natural teeth and proprioception.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1537468"},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral care medications for the prevention and treatment of ventilator-associated pneumonia in intensive care unit.","authors":"Hua Huang, Xiaomin Yu, Chenxi Huang, Jumei Zeng, Yuqing Li","doi":"10.3389/froh.2025.1566355","DOIUrl":"10.3389/froh.2025.1566355","url":null,"abstract":"<p><p>This study aims to ameliorate the management of VAP in clinical practice and deliver more precise care in the ICU. Study selection using the appropriate critical appraisal tools was undertaken by three authors. This review provides an overview of empirical antibiotics, chlorhexidine, and povidone-iodine, which are currently commonly used in critical care. It also discusses oral medications and preparations that may be used to prevent and treat ICU ventilator-associated pneumonia, including new antibiotics, hydrogen peroxide solutions, sodium bicarbonate, octenidine, and oral herbal medicines. It also discusses ongoing research and potential applications, such as the antimicrobial effects of these agents in ICU oral hygiene. Pharmaceuticals and formulations used in oral hygiene are effective or have huge application potential in the prevention and treatment of VAP, but further research is needed to standardize oral health assessment and care practices to develop evidence-based personalized oral hygiene for critically ill patients.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1566355"},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of combined cyclosporin and azithromycin treatment on human mononuclear cells under lipopolysaccharide challenge.","authors":"Norah Alotaibi, Aminah Alesawy, Marwa Alalshaikh, Faisal E Aljofi, Nada Aldossary, Nada Alzahrani, Omar Omar, Marwa Madi","doi":"10.3389/froh.2025.1544821","DOIUrl":"10.3389/froh.2025.1544821","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the combined effects of azithromycin and varying concentrations of cyclosporin on peripheral blood mononuclear cells (PBMCs) under lipopolysaccharide (LPS) stimulation.</p><p><strong>Materials and methods: </strong>PBMCs were isolated from four healthy donors and treated with cyclosporin at concentrations of (50, 200, and 1,000 ng/ml) either alone or in combination with azithromycin (0.4 µg/ml), with and without 100 ng ml LPS derived from Porphyromonas gingivalis. Total cell count, cell viability, and lactate dehydrogenase (LDH) activity were assessed at day 1 and 3. While the inflammatory mediators, including IL-6, IL-1β, IL-18, and IgA levels were assessed by ELISA at day 3. Statistical analysis included two-way ANOVA to analyze the effects of the drugs and the presence of LPS (the two independent variables), followed by Tukey's HSD <i>post-hoc</i> test. Multiple linear regression models evaluating treatment effects, LPS exposure, and time points, with assessment of two-way interactions. Models were adjusted for relevant covariates and verified for statistical assumptions, with significance set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>Lower cyclosporin concentrations (50 and 200 ng/ml) combined with azithromycin maintained higher cell counts and showed reduced cytotoxicity compared to 1,000 ng/ml under LPS exposure. The 200 ng/ml cyclosporin-azithromycin combination demonstrated optimal results, reducing IL-6 and IL-1β levels while maintaining cell viability. Higher concentrations elevated IgA levels, particularly with LPS stimulation, suggesting enhanced immune response modulation.</p><p><strong>Conclusion: </strong>The combination of azithromycin with moderate cyclosporin concentrations (200 ng/ml) provides optimal immunomodulatory effects while maintaining cell viability. Higher cyclosporin doses (1,000 ng/ml) showed increased cytotoxicity despite enhanced immunomodulation.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1544821"},"PeriodicalIF":3.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating design thinking into dental education.","authors":"Supachai Chuenjitwongsa, Lisa R Amir, Abbas Jessani, Lakshman P Samaranayake, Thanaphum Osathanon","doi":"10.3389/froh.2025.1547335","DOIUrl":"10.3389/froh.2025.1547335","url":null,"abstract":"<p><p>Design thinking is a human-centred, iterative process that aims to develop innovative solutions tailored to user needs. This article examines the groundwork and incorporation of design thinking in healthcare and medical education, highlighting its potential benefits in dental education, including enhancements in learner-centred approaches, faculty development, interprofessional collaboration, and person-centred care. Design thinking methods foster learner engagement, aligning with cognitive and constructivist learning theories. Active engagement and discourse among learners create meaningful learning experiences, benefiting from a \"learning by doing\" approach. Further, design thinking processes ensure critical thinking and collaborative learning, supporting active engagement with prior knowledge and constructive feedback skills. Thus, applying design thinking in dental education could deepen learners' understanding with improved problem-solving skills, ultimately leading to effective learning outcomes.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1547335"},"PeriodicalIF":3.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Impact of cerebrovascular stroke on inflammatory periodontal indices: a systematic review with meta-analysis and trial sequential analysis of case-control studies.","authors":"Mario Dioguardi, Maria Eleonora Bizzoca, Stefania Cantore, Giorgia Apollonia Caloro, Gennaro Musella, Filiberto Mastrangelo, Lorenzo Lo Muzio, Andrea Ballini","doi":"10.3389/froh.2025.1580261","DOIUrl":"https://doi.org/10.3389/froh.2025.1580261","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/froh.2024.1473744.].</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1580261"},"PeriodicalIF":3.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}