Frontiers in oral healthPub Date : 2025-06-17eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1538886
Juan Huang, Fanghua Gong, Zhou Chen, Yali Chen, Yufei Liu
{"title":"Application and effectiveness of experiential education combined with health coaching techniques in extended care for elderly patients with dental implants.","authors":"Juan Huang, Fanghua Gong, Zhou Chen, Yali Chen, Yufei Liu","doi":"10.3389/froh.2025.1538886","DOIUrl":"10.3389/froh.2025.1538886","url":null,"abstract":"<p><strong>Objective: </strong>Experiential education (EE) and health coaching techniques (HCT) were proved to be effective in health management. This study investigated the effectiveness of EE combined with HCT in extended care for elderly patients with dental implants.</p><p><strong>Methods: </strong>A total of 90 elderly patients who received implant restoration were randomly divided into intervention group (IG) and control group (CG). CG received standard health education. IG received EE, HCT and standard health education. Periodontal conditions of peri-implants (plaque Index, PLI; sulcus bleeding index, SBI; gingival Index, GI) were assessed at 1-, 3-, and 6-months. Oral health self-efficacy and implant survival rates after 6 months were compared between two groups.</p><p><strong>Results: </strong>No significant differences in periodontal indices were observed between groups at 1 and 3 months post-intervention. After 6 months of intervention, the experimental group showed significantly superior PLI, mSBI, and GI scores relative to the control group (<i>P</i> < 0.05). IG also showed an improvement in oral health self-efficacy compared to the CG (<i>P</i> < 0.05). The implant survival rate in the IG was higher than in the CG after 6 months, but the difference was not significant.</p><p><strong>Conclusion: </strong>EE combined with HCT improves oral health self-efficacy and periodontal health in elderly patients with dental implants.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1538886"},"PeriodicalIF":3.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-06-17eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1603267
Jasmine Cheuk Ying Ho, Hollis Haotian Chai, Ivy Guofang Sun, Michelle Zeping Huang, Edward Chin Man Lo, Chun Hung Chu
{"title":"Essential qualities for dental practice: dental students' perspectives in Hong Kong.","authors":"Jasmine Cheuk Ying Ho, Hollis Haotian Chai, Ivy Guofang Sun, Michelle Zeping Huang, Edward Chin Man Lo, Chun Hung Chu","doi":"10.3389/froh.2025.1603267","DOIUrl":"10.3389/froh.2025.1603267","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this quantitative study is to explore the perspectives of dental students in Hong Kong regarding the key qualities that define a good dentist and a successful dentist.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted to Hong Kong dental students in 2024 using an anonymous questionnaire. The questionnaire basically consisted of four self-administered questions. The first two questions examined the qualities that dental students associate with \"a successful dentist\" and \"a good dentist,\" respectively. The third question focused on the qualities expected of their dentist, and the fourth question investigated the qualities that dental school training should emphasize. For each question, respondents were requested indicate three key or most essential qualities. They could write down or choose the qualities provided in the list with 24 qualities.</p><p><strong>Results: </strong>All 452 students in the dental school were invited and 399 students (88%) completed the survey. \"Clinically competent\" and \"Good communication skills\" and \"Responsible/accountable\" emerged as the top three qualities across the first three questions. They identified \"Clinically competent\", \"Good communication skills\" and \"knowledgeable\" are three key qualities to be cultivated during training in dental school.</p><p><strong>Conclusions: </strong>Hong Kong dental students consider clinically competent, good communication skills, and being responsible/accountable are the key qualities for both good and successful dentists. These are also the key qualities they expected from their own dentist. Additionally, they emphasize the importance for dental schools to provide training that fosters clinical expertise, communication proficiency, and comprehensive knowledge to ensure graduates can deliver high-quality patient care.</p><p><strong>Significance: </strong>This survey offers important insights into the key qualities that dental students in Hong Kong believe are important for being a good and successful dentist. These findings can guide dental education to better prepare future professionals. Understanding these perspectives can help align educational goals with professional expectations, improving patient care and job satisfaction.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1603267"},"PeriodicalIF":3.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-06-17eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1609961
Amr Sayed Ghanem, Róbert Bata, Nóra Kovács, Attila Csaba Nagy
{"title":"Sociodemographic inequalities in the global burden trends and machine learning-based projections of periodontitis from 1990 to 2030 across different development levels.","authors":"Amr Sayed Ghanem, Róbert Bata, Nóra Kovács, Attila Csaba Nagy","doi":"10.3389/froh.2025.1609961","DOIUrl":"10.3389/froh.2025.1609961","url":null,"abstract":"<p><strong>Introduction: </strong>Oral diseases affect billions globally, with periodontitis contributing to significant health disparities and systemic conditions like diabetes and cardiovascular diseases.</p><p><strong>Methods: </strong>This study utilized the GBD 2021 dataset to assess the global burden of periodontitis across 204 countries, analyzing prevalence, incidence, and DALY rates. Socioeconomic disparities were examined using the Sociodemographic Index (SDI) and Gini coefficient, while time-series analysis, regression models, and Joinpoint regression identified trends. Machine learning predicted future burden, and geospatial mapping visualized global distribution.</p><p><strong>Results: </strong>Periodontitis burden remains highest in low-SDI regions, with significantly greater prevalence, incidence, and DALY rates compared to higher-SDI countries (<i>p</i> < 0.001). Global trends showed a decline until 2010 (AAPC: ASPR -0.792%, ASIR -0.719%, DALY -0.794%; all <i>p</i> < 0.05), followed by a temporary increase before stabilizing. Disparities widened over time, peaking around 2010. Projections suggest persistent inequalities, with low-SDI regions maintaining the highest burden and minimal expected reductions, while higher-SDI countries exhibit stable, lower rates.</p><p><strong>Conclusion: </strong>Despite global declines, periodontitis disparities have widened, with low-SDI regions facing the highest burden and minimal improvements. Without strong public health policies integrating preventive oral health into diseases management, inequalities will persist, worsening systemic health outcomes. Urgent action is needed to ensure universal access to periodontal care and early interventions, especially in low-resource settings.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1609961"},"PeriodicalIF":3.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-06-17eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1636210
Juliana L Schussel, Mariana Villarroel-Dorrego, Sven Niklander
{"title":"Editorial: Incidence, mortality, and risk factors for oral cancers.","authors":"Juliana L Schussel, Mariana Villarroel-Dorrego, Sven Niklander","doi":"10.3389/froh.2025.1636210","DOIUrl":"10.3389/froh.2025.1636210","url":null,"abstract":"","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1636210"},"PeriodicalIF":3.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-06-16eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1635675
Rania H Younis, Ranee Mehra, Nikolaos G Nikitakis
{"title":"Editorial: Immuno-oncologic biomarker signatures for personalized immunotherapy and immunoprevention in oral squamous cell carcinoma.","authors":"Rania H Younis, Ranee Mehra, Nikolaos G Nikitakis","doi":"10.3389/froh.2025.1635675","DOIUrl":"10.3389/froh.2025.1635675","url":null,"abstract":"","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1635675"},"PeriodicalIF":3.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-06-13eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1557008
Anna Rachel Dos Santos Soares, Carlos Antonio Gomes da Cruz, Maria Luíza Viana Fonseca, Líria Sheila Chamane, Loliza Luiz Figueiredo Houri Chalub, Raquel Conceição Ferreira
{"title":"Education- and income-based inequalities of functional dentition by dental service utilization.","authors":"Anna Rachel Dos Santos Soares, Carlos Antonio Gomes da Cruz, Maria Luíza Viana Fonseca, Líria Sheila Chamane, Loliza Luiz Figueiredo Houri Chalub, Raquel Conceição Ferreira","doi":"10.3389/froh.2025.1557008","DOIUrl":"10.3389/froh.2025.1557008","url":null,"abstract":"<p><strong>Introduction: </strong>This study analyzed the magnitude of education- and income-based inequalities in functional dentition (FD) among Brazilian adults between 2013 and 2019, considering dental service utilization.</p><p><strong>Methods: </strong>This study based on repeated cross-sectional surveys using secondary data from a probabilistic sample of adults (18-59 years old) who participated in the 2013 and 2019 National Health Survey (NHS). Only individuals who reported having used dental services were included. FD was defined as having ≥21 teeth, based on self-reported tooth loss in the maxillary and mandibular arches. Variables included sex, age, education (years of study), and per capita family income (measured in minimum wages). Dental service utilization was assessed using the question \"When was the last time you visited a dentist?\" with responses dichotomized into \">1 year\" and \"≤1 year\". Absolute and relative inequalities in FD were assessed using the slope index of inequality (SII) and the relative index of inequality (RII), respectively, based on education and income. Generalized linear models (log-binomial regression) were applied with a logarithmic link function to estimate RII (rate ratios) and an identity link function to estimate SII (rate differences), adjusting for sex and age. Trends between 2013 and 2019 and differences in SII and RII by dental service utilization were assessed through two-way interaction terms in the models. All analyses accounted for the survey's complex sampling design and sample weights.</p><p><strong>Results: </strong>The prevalence of FD was 85.95% (2013) and 89.45% (2019) (<i>p</i> < 0.001). SII and RII indicated greater FD prevalence among higher socioeconomic groups, with the magnitude of education-based inequality higher than income-based inequality. Education-based inequalities decreased from 2013-2019. Educational inequalities were more pronounced among those who used dental services >1 year (<i>p</i> < 0.001), whereas income-based inequalities did not differ by dental service utilization (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>Despite the reduction in FD education-based inequality in Brazil, persistent disparities were observed between socioeconomic groups, with the lowest inequalities found among adults who used dental services ≤1 year. This indicates the importance of interventions aimed at reducing barriers and promoting access to services for the most vulnerable populations.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1557008"},"PeriodicalIF":3.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-06-12eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1615050
Esther Muñoz-Soto, Firas Elmsmari, Okba Mahmoud, José Antonio González
{"title":"Case Report: Apical periodontitis due to calculus-like deposit on the external surface of the root apex.","authors":"Esther Muñoz-Soto, Firas Elmsmari, Okba Mahmoud, José Antonio González","doi":"10.3389/froh.2025.1615050","DOIUrl":"10.3389/froh.2025.1615050","url":null,"abstract":"<p><strong>Purpose: </strong>Herein, we report a rare case of chronic apical periodontitis associated with an extraradicular calculus-like deposit on the root apex of a mandibular left central incisor that was previously treated with root canal therapy.</p><p><strong>Case presentation: </strong>A 42-year-old man presented with persistent sinus tract formation. Despite non-surgical retreatment, the symptoms persisted, and radiographic evaluations, including cone-beam computed tomography, revealed a periapical radiolucency with radiopaque convexities in the apical third of the root. Intentional replantation (IR) was performed to allow direct clinical access for diagnosis and management. Upon extraction, a dark brown, calculus-like deposit firmly attached to the external root surface was observed. After deposit removal, root-end resection and retrograde filling were performed before replantation. Follow-ups at 3 months and 1 year revealed complete healing of the sinus tract and significant radiographic improvements. This case highlights the role of extraradicular biofilms and apical mineralized deposits in persistent periapical inflammation. Sinus tracts may facilitate mineral-ion migration and contribute to the formation of extra-radicular calculi. Mineralized biofilms may not be resolved using orthograde approaches, necessitating surgical intervention.</p><p><strong>Conclusion: </strong>IR enables thorough inspection and removal of radicular deposits, offering a minimally invasive and successful alternative to conventional apical surgery. The findings in this case are consistent with those in previous studies suggesting the usefulness of IR for managing refractory periapical lesions caused by extraradicular infections or mineralized biofilms.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1615050"},"PeriodicalIF":3.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigating the relationships among oral health-related knowledge, attitude, practice, and self-efficacy in predicting oral health behaviors among female Iranian students.","authors":"Akram Mehtari Taheri, Alireza Hidarnia, Fatemeh Zarei, Mahmoud Tavousi","doi":"10.3389/froh.2025.1533519","DOIUrl":"10.3389/froh.2025.1533519","url":null,"abstract":"<p><strong>Background: </strong>Dental caries and other oral health conditions, such as periodontal disease and halitosis, are significant global health issues, particularly among adolescents. Understanding how oral health-related knowledge, attitudes, practices, and self-efficacy contribute to the adoption of preventive oral health behaviors is therefore crucial. This study aimed to investigate the relationships among these factors in predicting oral health behaviors among female Iranian students.</p><p><strong>Methods: </strong>This cross-sectional analytical study was conducted from April to May 2023 and included 290 seventh-grade adolescent female students from schools in Kashan city. Data were collected via a validated questionnaire measuring knowledge, attitudes, practices, and self-efficacy regarding oral and dental health behaviors. Descriptive statistics, Pearson correlation, and regression analyses were performed via SPSS 24 software.</p><p><strong>Findings: </strong>The mean ± SD scores for knowledge, attitudes, self-efficacy, and practices were 5.72 ± 1.90, 56.22 ± 6.43, 49.81 ± 12.89, and 26.90 ± 6.28, respectively. Spearman's correlation coefficient revealed a strong relationship between self-efficacy and oral health behaviors (<i>r</i> = 0.657). Regression analysis revealed that self-efficacy was the most significant predictor of oral health behaviors (<i>β</i> = 0.349).</p><p><strong>Conclusion: </strong>The findings indicate that self-efficacy plays a key role in predicting oral health behaviors among adolescent students. Given its strong influence, educational interventions should focus on enhancing self-efficacy alongside improving knowledge, attitudes, and practices to promote better oral health behaviors.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1533519"},"PeriodicalIF":3.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-06-12eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1589764
Elizabeth Konneker, Devon Singh, Marisol Tellez, Amid I Ismail, Eugene M Dunne
{"title":"A mixed methods exploration of the origin of dental anxiety and coping strategies among participants in a behavioral intervention for dental anxiety.","authors":"Elizabeth Konneker, Devon Singh, Marisol Tellez, Amid I Ismail, Eugene M Dunne","doi":"10.3389/froh.2025.1589764","DOIUrl":"10.3389/froh.2025.1589764","url":null,"abstract":"<p><strong>Introduction: </strong>Little is known about the onset and early progression of dental anxiety. The current mixed-methods study aimed to evaluate patient-reported early experiences and onset of dental anxiety, as well as the experience of managing dental anxiety (i.e., coping strategies and symptom severity).</p><p><strong>Methods: </strong>Adults (N=499) were recruited from a dental school clinic to participate in a clinical trial testing the efficacy of a cognitive behavioral therapy (CBT)-based intervention for dental anxiety. As one aspect of this trial, participants answered the Anxiety and Related Disorders Interview Schedule. During this interview, participants described when they first noticed developing anxiety about dental appointments, as well as how they coped during their appointments. Assessments were repeated at one-month and three-month follow-ups. Bivariate associations (e.g., chi-square and t-test) and repeated measures ANOVA were explored. Qualitative data were coded in NVivo.</p><p><strong>Results: </strong>The three identified origins for dental anxiety were: \"traumatic dental visit in childhood,\" \"traumatic dental visit in adulthood,\" and \"anxiety has always been present.\" Participants who reported a childhood trauma had the highest levels of dental anxiety relative to the other two groups. In total, 30 unique coping mechanisms were identified. A reduction in avoidant coping strategies was observed among the intervention groups at both one-month and three-months, but not in the control group.</p><p><strong>Discussion: </strong>Earlier negative dental experiences are more likely to result in greater anxiety severity. A one-time CBT-based dental anxiety treatment reduced the use of avoidant coping strategies, which may in turn reduce patient fears.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1589764"},"PeriodicalIF":3.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-06-12eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1574425
Rodolfo Mauceri, Martina Coppini, Gaetano La Mantia, Giuseppe Seminara, Mario Pérez-Sayáns, Corrado Toro, Rita Vitagliano, Hitoshi Kawamata, Toshiki Hyodo, Giuseppe Colella, Vito Rodolico, Giuseppina Campisi
{"title":"Oral squamous cell carcinoma vs. medication-related osteonecrosis of the jaw in patients assuming bone-modifying agents: a diagnostic challenge in a multi-hospital case series.","authors":"Rodolfo Mauceri, Martina Coppini, Gaetano La Mantia, Giuseppe Seminara, Mario Pérez-Sayáns, Corrado Toro, Rita Vitagliano, Hitoshi Kawamata, Toshiki Hyodo, Giuseppe Colella, Vito Rodolico, Giuseppina Campisi","doi":"10.3389/froh.2025.1574425","DOIUrl":"10.3389/froh.2025.1574425","url":null,"abstract":"<p><strong>Background: </strong>Despite advances in the diagnosis of oral squamous cell carcinoma (OSCC), most cases are diagnosed in advanced stages, influencing negatively the patient's prognosis. The absence of specific signs and symptoms contributes to the diagnostic delay of OSCC, often leading to confusion with various oral conditions, including, in patients with a history of bone modifying agents (BMA) and/or anti-angiogenic (AA) molecules, the Medication-Related Osteonecrosis of the Jaw (MRONJ). This study aims to investigate the characteristics of OSCC and MRONJ, focusing on clinical and radiological features of a multicenter series.</p><p><strong>Methods: </strong>According to STROBE statements, 11 patients collected by different centers and affected by OSCC undergoing BMA or AA therapy, with clinical and radiological features resembling MRONJ were reported (6 in Italy and 5 in Japan). Due to the suspicion of a malignant neoplasia, incisional biopsies for histological examination were performed.</p><p><strong>Results: </strong>In all eleven patients under ONJ-associated therapy, discerning between OSCC and MRONJ was a real challenge due to overlapping clinical and radiological features. The present case series highlights the importance of considering the possibility of malignant disease in patients undergoing ONJ-associated therapy.</p><p><strong>Conclusion: </strong>Although biopsy is commonly considered unnecessary for MRONJ diagnosis, our findings highlight the importance of selectively performing bioptic procedures in patients taking ONJ-associated therapy to exclude the malignant nature of oral lesions promptly.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1574425"},"PeriodicalIF":3.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}