Frontiers in oral healthPub Date : 2025-09-02eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1603814
Chukwuemeka L Anyikwa, Peter A Brennan, Chukwuebuka E Ogwo
{"title":"Missed preoperative nursing care in dentistry.","authors":"Chukwuemeka L Anyikwa, Peter A Brennan, Chukwuebuka E Ogwo","doi":"10.3389/froh.2025.1603814","DOIUrl":"10.3389/froh.2025.1603814","url":null,"abstract":"<p><p>Missed preoperative nursing care in dentistry is a critical but overlooked public health issue in many low-resource settings worldwide, including regions across Africa, Southeast Asia, and Latin America. In numerous low and middle-income countries, dental emergencies are managed almost exclusively by dentists, with minimal structured nursing support. This gap in care contributes to delayed interventions, preventable morbidity and mortality, and rising healthcare costs. A systemic approach is urgently needed to integrate nursing into dental emergency management. This includes expanding nursing education to cover oral health, developing standardized nursing protocols for dental infections and fostering multidisciplinary collaboration between the nursing and dental professionals. While successful models from high-income countries offer promising frameworks, their adaptation requires careful consideration of local health system capacities and cultural contexts. Although empirical data on the economic and clinical impact of missed dental nursing care remain limited, addressing this gap is a pressing public health priority. Doing so offers a cost-effective opportunity to strengthen healthcare infrastructure and improve outcomes for vulnerable populations in underserved regions.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1603814"},"PeriodicalIF":3.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of individualized osteotomy and registration guide plate in temporomandibular joint gap arthroplasty: a pilot clinical study.","authors":"Jianfei Zhang, Jian Sun, Tengfei Jiang, Guokai Zhou, Yuan Tian, Liang Xia, Wenbin Zhang","doi":"10.3389/froh.2025.1655362","DOIUrl":"10.3389/froh.2025.1655362","url":null,"abstract":"<p><strong>Introduction: </strong>Temporomandibular joint (TMJ) ankylosis severely compromises mandibular mobility and overall oral function. Gap arthroplasty remains the standard surgical treatment. However, the accuracy of navigation-assisted procedures is frequently limited by anatomical registration challenges, particularly when relying on dental surface matching.</p><p><strong>Methods: </strong>This single-center prospective study enrolled 30 patients with unilateral bony TMJ ankylosis. Participants were randomly assigned to either a dental surface registration group (<i>n</i> = 18) or a guide plate registration group (<i>n</i> = 12). The patient-specific guide plate integrated both osteotomy slots and fiducial markers. Primary outcomes included registration time and target registration error (TRE). Secondary outcomes were operative time, mouth opening at three months, and perioperative complications.</p><p><strong>Results: </strong>The guide plate group achieved significantly shorter registration times (56.23 ± 11.33 s; 95% CI: 49.35-63.11) compared with the dental registration group (935.03 ± 85.40 s; 95% CI: 894.55-975.51; <i>P</i> < 0.001). TRE was also significantly lower in the guide plate group (0.69 ± 0.10 mm; 95% CI: 0.62-0.76) than in the dental registration group (2.82 ± 0.45 mm; 95% CI: 2.60-3.04; <i>P</i> < 0.001). Average operative time was reduced in the guide plate group (124.63 ± 5.39 min; 95% CI: 121.44-127.82) compared with the dental group (134.31 ± 12.76 min; 95% CI: 128.10-140.52; <i>P</i> = 0.009). Postoperative mouth opening at three months was comparable between groups (31.5 ± 4.23 mm; 95% CI: 28.94-34.06 vs. 31.33 ± 3.34 mm; 95% CI: 29.65-33.01; <i>P</i> = 0.905). No major intraoperative or postoperative complications were observed.</p><p><strong>Discussion: </strong>Integration of an individualized osteotomy and registration guide plate significantly improved intraoperative efficiency and spatial accuracy in TMJ gap arthroplasty without compromising functional outcomes. These pilot findings support the clinical feasibility of the guide plate system, though larger multicenter studies and evaluation of inter-operator variability are required for broader validation.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1655362"},"PeriodicalIF":3.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-09-02eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1667604
Paul D Terry, O Lee Wilson, Matthew L Heaton, Orpheus Triplett, R Eric Heidel, Rajiv Dhand
{"title":"Accuracy of digital photographs for assessing inflammatory gum disease in epidemiologic studies.","authors":"Paul D Terry, O Lee Wilson, Matthew L Heaton, Orpheus Triplett, R Eric Heidel, Rajiv Dhand","doi":"10.3389/froh.2025.1667604","DOIUrl":"10.3389/froh.2025.1667604","url":null,"abstract":"<p><strong>Background: </strong>Incorporating gum disease assessment into epidemiologic studies would facilitate investigations of disease etiology.</p><p><strong>Objective: </strong>We evaluated the accuracy and inter-rater reliability of experienced dental health professionals' visual assessments of digital photographs to determine inflammatory gum disease.</p><p><strong>Methods: </strong>Raters viewed anonymized photographs of the teeth and gums of 30 adult patients and were asked to distinguish \"healthy\" gingiva from \"gum disease\" and to assess disease severity. Frequency, percentage, and cross-tabulation statistics were used to perform diagnostic calculations including sensitivity, specificity, and overall accuracy. Fleiss' Kappa, with a 95% confidence interval, was used to test for interrater reliability amongst the four raters. Cohen's Kappa was then calculated for each potential pairing of the four raters.</p><p><strong>Results: </strong>The accuracy of determining active inflammatory gum disease from digital photographs ranged from 76.7% to 96.7% (mean 85.9%) across the four raters. Sensitivity ranged from 70% to 95% (mean 82.5%), and specificity ranged from 80% to 100% (mean 92.5%). However, inter-rater reliability for disease severity was only fair, with Fleiss's Kappa for gingivitis and periodontitis 0.25 (0.00-0.51) and 0.28 (0.03-0.54), respectively.</p><p><strong>Conclusion: </strong>Our findings show that digital photographs could be useful for assessing inflammatory gum disease in epidemiologic studies of inflammation-mediated chronic systemic diseases.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1667604"},"PeriodicalIF":3.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-08-29eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1641307
Olubukola O Olatosi, Robert J Schroth, Daniella DeMaré, Maria Manigque, Betty-Anne Mittermuller, Jeanette Edwards, Katherine Yerex, Peter D Wong, Josée Lavoie, Julianne Sanguins, Prashen Chelikani, Alexandra Nicolae, Jesse Lamoureux, Rhonda Campbell, Mary Bertone, Maryam Amin
{"title":"Identifying training needs of healthcare providers to implement caries risk assessment.","authors":"Olubukola O Olatosi, Robert J Schroth, Daniella DeMaré, Maria Manigque, Betty-Anne Mittermuller, Jeanette Edwards, Katherine Yerex, Peter D Wong, Josée Lavoie, Julianne Sanguins, Prashen Chelikani, Alexandra Nicolae, Jesse Lamoureux, Rhonda Campbell, Mary Bertone, Maryam Amin","doi":"10.3389/froh.2025.1641307","DOIUrl":"10.3389/froh.2025.1641307","url":null,"abstract":"<p><strong>Background: </strong>Early childhood caries remains a pressing concern among Indigenous children in Canada, driven by systemic inequities, limited access to care, and fragmented service delivery. Integrating caries risk assessment (CRA) into primary care presents an opportunity to improve early detection and prevention. This study explored the training needs and preferred delivery methods of non-dental primary care providers (NDPCPs) to support CRA implementation in Indigenous pediatric settings.</p><p><strong>Methods: </strong>This qualitative exploratory study involved 50 NDPCPs serving First Nations and Métis children under six years of age across 10 communities in Manitoba. Data were collected between April 2023 and February 2025 through eight focus groups and 12 key informant interviews, followed by brief individual interviews to assess preferred training modalities. Transcripts were analyzed using thematic analysis to identify key training needs and preferences.</p><p><strong>Results: </strong>Participants included physicians, nurse practitioners, public health nurses, physician assistants, dietitians, and child development workers. Four core training areas were identified: dental caries screening, CRA tool usage, fluoride varnish application, and documentation/referral processes. An additional cross-cutting theme emphasized the importance of culturally safe and trauma-informed training. Despite recognizing the CRA tool's value and ease of use, participants reported limited formal training in preventive oral health and stressed the need for hands-on, culturally appropriate instruction. Preferred training modalities varied by geography: urban providers favored blended in-person and online approaches, while rural providers preferred online formats due to travel constraints. Overall, in-person and interactive training was most preferred.</p><p><strong>Conclusion: </strong>NDPCPs require structured, context-specific training to effectively integrate CRA into routine care. A hybrid training model combining online modules with locally delivered, hands-on learning may best address geographic and resource-based disparities. Training content should be simple, skill-focused, and culturally responsive to support NDPCPs in delivering equitable oral healthcare to Indigenous children.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1641307"},"PeriodicalIF":3.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-08-28eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1612982
Laura Agnes Ingrid Magerfleisch, Nertsa Cunoti, Rezart Qorri, Katharina Marilena Weil, Hannah Tröger, Juliane Häring, Lisa Irmscher, Katja Petrowski, Hendrik Berth
{"title":"Correlations between psychological anxiety symptoms and physical anxiety symptoms in dental anxiety-a cross-sectional study with 1327 patients.","authors":"Laura Agnes Ingrid Magerfleisch, Nertsa Cunoti, Rezart Qorri, Katharina Marilena Weil, Hannah Tröger, Juliane Häring, Lisa Irmscher, Katja Petrowski, Hendrik Berth","doi":"10.3389/froh.2025.1612982","DOIUrl":"10.3389/froh.2025.1612982","url":null,"abstract":"<p><strong>Background: </strong>Dental anxiety is a prevalent phenomenon with the potential to impact both psychological well-being and oral health outcomes. It may lead to individuals avoiding treatment. This study aims to explore the relationship between psychological anxiety symptoms and physical anxiety symptoms in dental anxiety.</p><p><strong>Methods: </strong>Between 2019 and 2022, a cross-sectional study was conducted including 1,327 patients from a variety of dental practices in Germany and students (age range: 18-85 years; mean: 39.65 years, 60.7% female). Participants completed validated questionnaires, including the Dental Anxiety Scale (DAS), the Scale Somato-visceral arousal of the Dental Fear Survey (DFS-SVA), the Brief Symptom Inventory 18 (BSI-18 GSI), and the Oral Health Impact Profile (OHIP-5). Data was analysed using Mann-Whitney-U-tests, Spearman correlations, Kruskal-Wallis-tests and linear regression models. The significance level was set at <i>p</i> = 0.05.</p><p><strong>Results: </strong>The mean value for dental anxiety (DAS) was 9.81 (SD = 4.07) and for physical anxiety symptoms (DFS-SVA) 10.51 (SD = 4.70). Of the participants, 808 (60.9%) reported no dental anxiety, 368 (27.7%) were somewhat anxious and 151 (11.4%) reported severe dental anxiety. A strong correlation was observed between DAS and DFS (<i>r</i> = 0.544), while moderate correlations were found between DAS and BSI-18 (<i>r</i> = 0.300) and between DAS and OHIP-5 (<i>r</i> = 0.371). The application of regression analysis indicated that DFS-SVA was the strongest predictor of DAS scores (<i>β</i> = 0.434, <i>p</i> < 0.001), followed by BSI-18 GSI (<i>β</i> = 0.285, <i>p</i> < 0.001) and age (<i>β</i> = 0.174, <i>p</i> < 0.001). Gender was not found to have a significant influence on results. A significant disparity was observed in the results between male and female scores and on the DAS, DFS-SVA, and BSI-18 GSI compared to men.</p><p><strong>Conclusion: </strong>The study corroborates substantial correlation between psychological dental anxiety and physical anxiety symptoms. These findings underscore the necessity for early detection and targeted interventions within dental practices with the aim of enhancing both oral health and overall quality of life. It is recommended that future research endeavours focus on the investigation of causal relationships and the identification of effective treatment strategies to further enhance patient care.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1612982"},"PeriodicalIF":3.1,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-08-26eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1654428
Dinda Kurnia Fitri, Nozimjon Tuygunov, Wan Himratul Aznita Wan Harun, Isty Adhitya Purwasena, Arief Cahyanto, Myrna Nurlatifah Zakaria
{"title":"Key virulence genes associated with <i>Streptococcus mutans</i> biofilm formation: a systematic review.","authors":"Dinda Kurnia Fitri, Nozimjon Tuygunov, Wan Himratul Aznita Wan Harun, Isty Adhitya Purwasena, Arief Cahyanto, Myrna Nurlatifah Zakaria","doi":"10.3389/froh.2025.1654428","DOIUrl":"10.3389/froh.2025.1654428","url":null,"abstract":"<p><strong>Introduction: </strong><i>Streptococcus mutans</i> is central to plaque-induced oral diseases due to its robust biofilm-forming ability. Understanding the genetic and regulatory basis of this process is critical for developing targeted anti-virulence strategies that preserve the balance of the oral microbiome. This systematic review aims to gather and evaluate existing evidence on the virulence genes associated with <i>Streptococcus mutans</i> biofilm formation.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, Scopus, and Web of Science was conducted in accordance with PRISMA guidelines. Studies investigating the genetic and regulatory mechanisms of biofilm formation, as well as the effects of experimental treatments, were included, and the risk of bias was assessed using the QUIN tool.</p><p><strong>Results: </strong>Key virulence genes were identified, including glucosyltransferases <i>(gtfB, gtfC, gtfD)</i>, glucan-binding proteins <i>(gbpB, gbpC)</i>, and two-component systems <i>(vicRK, liaSR)</i>. These genes contribute to adhesion, extracellular polysaccharide synthesis, and environmental adaptation, processes critical for biofilm development. Various anti-virulence strategies, such as quorum sensing inhibitors and gene-targeted compounds, show promise in controlling biofilm formation without compromising bacterial viability, thereby preserving the homeostasis of the normal oral flora, which is essential for maintaining overall oral health.</p><p><strong>Conclusion: </strong>While key virulence genes have been well characterized, further research is needed to clarify how their regulation is influenced by environmental conditions. Insights from this review may support the development of novel therapeutic approaches that reduce <i>Streptococcus mutans</i> pathogenicity while maintaining oral microbial balance.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024577977, PROSPERO CRD42024577977.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1654428"},"PeriodicalIF":3.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bruxism and other jaw loading behaviours are associated with somatic symptoms and psychological distress in orofacial pain-free adults: a cross-sectional study.","authors":"Nontawat Chuinsiri, Peungchaleoy Thammanichanon, Pornputthi Puttaravuttiporn, Wittawat Mongkolchart, Chadatorn Chudet, Sirada Thongraksri","doi":"10.3389/froh.2025.1622386","DOIUrl":"10.3389/froh.2025.1622386","url":null,"abstract":"<p><strong>Background: </strong>Oral behaviours, both functional and non-functional, are commonly reported and can negatively impact oral health. Among orofacial pain patients, non-functional oral behaviours have been observed in association with elevated psychosocial factors. However, the extent to which these findings apply to individuals without orofacial pain remains inconclusive. This study examined the latent constructs of oral behaviours and their associations with somatic symptoms and psychological distress in orofacial pain-free adults.</p><p><strong>Methods: </strong>This multi-centre cross-sectional study recruited 194 participants who were free of orofacial pain. All participants provided informed consent and completed a set of self-reported questionnaires, including the Oral Behaviour Checklist-21, the Patient Health Questionnaire (PHQ)-15 for assessing somatic symptoms and the PHQ-4 for assessing psychological distress. Exploratory factor analysis (EFA) was conducted to identify latent constructs underlying the observed questionnaire item responses. Correlations between questionnaire scores were assessed using the Spearman's rank correlation test. A <i>p</i> value of less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The mean age of participants was 24.6 ± 6.2 years, and 70% were female. Exploratory factor analysis identified three distinct latent constructs of oral behaviours: tooth-contact bruxism, non-tooth-contact bruxism and other jaw loading behaviours. Overall oral behaviours, sleep-state behaviours, awake-state behaviours and the EFA-derived constructs showed statistically significant positive correlations with both somatic symptoms and psychological distress.</p><p><strong>Conclusions: </strong>In addition to being classified by sleep and awake states, oral behaviours can be grouped into tooth-contact bruxism, non-tooth-contact bruxism and other jaw loading behaviours. The significant correlations observed among oral behaviours, somatic symptoms and psychological distress suggest that individuals reporting frequent oral behaviours should be further evaluated for underlying psychosocial factors, even in the absence of orofacial pain.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1622386"},"PeriodicalIF":3.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-08-25eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1646382
Nireeksha, Alexander Maniangat Luke, Suchetha Kumari N, Mithra N Hegde, Nishmitha N Hegde
{"title":"Metabolic interplay of SCFA's in the gut and oral microbiome: a link to health and disease.","authors":"Nireeksha, Alexander Maniangat Luke, Suchetha Kumari N, Mithra N Hegde, Nishmitha N Hegde","doi":"10.3389/froh.2025.1646382","DOIUrl":"10.3389/froh.2025.1646382","url":null,"abstract":"<p><p>Short-chain fatty acids (SCFAs), primarily acetate (C2), propionate (C3), and butyrate (C4), are crucial microbial metabolites formed by the fermentation of dietary fibers by gut microbiota in the colon. These SCFAs, characterized by fewer than six carbon atoms, serve as an essential energy source for colonic epithelial cells and contribute approximately 10% of the body's total energy requirement. They are central to maintaining gut health through multiple mechanisms, including reinforcing intestinal barrier function, exerting anti-inflammatory effects, regulating glucose and lipid metabolism, and influencing host immune responses. Butyrate, in particular, plays a pivotal role in protecting the gut mucosa and modulating inflammatory processes. Beyond their intestinal functions, SCFAs affect systemic metabolic outcomes such as body weight regulation and appetite control by modulating the secretion of gut hormones and interacting with G-protein coupled receptors. Despite strong experimental evidence, mainly from animal models, clinical applications of SCFA modulation remain in preliminary stages, with limited translational findings in human therapeutics.In parallel, the oral microbiome also produces SCFAs, such as propionic, butyric, isobutyric, and isovaleric acids, as metabolic by-products in biofilm ecosystems like dental plaque. These acids contribute to interspecies communication, \"cross-feeding\" dynamics, and possibly biofilm stability or pathogenicity, especially in caries and periodontal disease. SCFAs in the oral cavity may act as signaling molecules or competitive factors, modulating microbial behavior and ecological balance within the oral niche. Collectively, these insights highlight SCFAs as integral to host-microbiota interactions, both in the gut and oral environments, with potential implications for targeted microbiome-based therapies in health and disease.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1646382"},"PeriodicalIF":3.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microbiological mechanisms of oral mucosal disease: oral-intestinal crosstalk and probiotic therapy.","authors":"Qi Zhou, Panpan Liu, Muni Chen, Hao He, Mengting Xu, Qianrong Xu, Jianfeng Yu, Yutian Deng, Jiayu Yan, Yueqiang Wen","doi":"10.3389/froh.2025.1485028","DOIUrl":"10.3389/froh.2025.1485028","url":null,"abstract":"<p><p>Balance of the oral-intestinal axis microbiota is essential for maintaining oral mucosal health. The occurrence of oral disease is closely linked to the microbiota, this disorder is closely related to the pathogenesis of oral mucosal diseases, such as oral lichen planus, recurrent aphthous ulcer, oral candidiasis and squamous-cell carcinoma. As a microorganism that is beneficial to host health, probiotics can show multi-dimensional therapeutic effects in oral mucosal diseases by targeting and regulating the immune microenvironment of the oral mucosa, inhibiting the colonization of pathogenic bacteria and repairing the barrier function. In this review, we will review the relevant roles that oral-gut microbial homeostasis plays in the pathogenesis of oral mucosal diseases and provide evidence for dysregulation of microbial homeostasis in patients with oral mucosal diseases, and explore specific probiotic strains by regulating oral and intestinal axis microbial homeostasis and host immune and inflammatory responses, in order to provide new ideas for the clinical treatment of oral mucosal diseases.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1485028"},"PeriodicalIF":3.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in oral healthPub Date : 2025-08-21eCollection Date: 2025-01-01DOI: 10.3389/froh.2025.1682460
Thuy Do, Divyashri Baraniya, Nezar Al-Hebshi
{"title":"Editorial: Investigating the role of periodontal microbiota in health and disease.","authors":"Thuy Do, Divyashri Baraniya, Nezar Al-Hebshi","doi":"10.3389/froh.2025.1682460","DOIUrl":"10.3389/froh.2025.1682460","url":null,"abstract":"","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1682460"},"PeriodicalIF":3.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}