Frontiers in oral health最新文献

{"title":"Salivary cell-free DNA methylation analysis for oncological monitoring of surgical resection of oral squamous cell carcinoma.","authors":"Zuzana Saidak, Marie Milly, Christophe Louandre, Emilien Colin, Pia-Manuela Rusu, Agnes Paasche, Stephanie Dakpe, Sylvie Testelin, Antoine Galmiche","doi":"10.3389/froh.2025.1614371","DOIUrl":"10.3389/froh.2025.1614371","url":null,"abstract":"<p><strong>Objective: </strong>Non-invasive analysis of tumor DNA in biological fluids offers promising perspectives for the oncological monitoring of cancer patients. Cancer-specific DNA methylation marks are detectable in the saliva of Oral Squamous Cell Carcinoma (OSCC) patients. We set up a salivary liquid biopsy approach for the oncological monitoring of OSCC referred for surgical resection.</p><p><strong>Material and methods: </strong>We analysed DNA methylation in TCGA-OSCC to identify genes with high methylation levels in tumor vs. matched non-tumor tissue. Cell-free DNA (cfDNA) methylation levels of selected genes were analysed in the saliva of OSCC patients (<i>n</i> = 30) before/after complete surgical resection by High Resolution Melting (HRM) analysis, and compared to non-cancer controls.</p><p><strong>Results: </strong>We identified five genes with higher DNA methylation levels in OSCC compared to matching non-tumor tissue that were analysable by HRM, and were independent of tumor stage, etiology or age. In 70% of OSCC, at least one of the five cfDNA methylation marks was detectable before surgery. Complete surgical resection led to a significant disappearance of salivary cfDNA methylation marks. In 52% of patients, we noted the persistence of at least one mark, shown to be related to close/positive surgical margin status. In one patient resected with R0 margin, the persistence of <i>ASCL1</i> methylation preceded tumor recurrence by 4 months.</p><p><strong>Conclusion: </strong>Salivary cfDNA methylation analysis offers a minimally invasive method to monitor the effectiveness of surgical resection of OSCC. Future studies with a larger cohort and longer follow-up are required to validate its use in this context.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1614371"},"PeriodicalIF":3.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing oral health outcomes through public health policy reform.","authors":"Chukwuemeka L Anyikwa, Chukwuebuka E Ogwo","doi":"10.3389/froh.2025.1604465","DOIUrl":"10.3389/froh.2025.1604465","url":null,"abstract":"<p><p>This article explores the transformative potential of public health policies to improve oral health outcomes through the integrated application of three fundamental pillars: sustainability, equity in healthcare access, and the reduction of oral health disease burden. By examining the interplay of these pillars, the discussion proposes strategies that not only enhance preventive measures and accessibility to dental care but also foster long-term, sustainable improvements in population oral health. The framework presented herein is intended to guide policymakers in creating evidence-based interventions that address disparities and mitigate the growing burden of oral diseases globally.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1604465"},"PeriodicalIF":3.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quorum sensing in <i>Porphyromonas gingivalis</i> and oral microbial interactions: a scoping review.","authors":"Zelda Ziyi Zhao, Wenwen Shan, Lifeng Guo, Chun Hung Chu, Jing Zhang","doi":"10.3389/froh.2025.1573863","DOIUrl":"10.3389/froh.2025.1573863","url":null,"abstract":"<p><strong>Objective: </strong><i>Porphyromonas gingivalis</i>, a major periodontal pathogen, interacts with other oral microbes through quorum sensing, enhancing its growth and virulence, which contributes to periodontitis. This scoping review aims to examine the role of quorum sensing in the interactions between <i>P. gingivalis</i> and other oral microbial species.</p><p><strong>Methods: </strong>Two independent researchers conducted a systematic search using the keywords {[(quorum sensing) OR QS] AND [(<i>Porphyromonas gingivalis</i>) OR <i>P. gingivalis</i>]} for English publications prior to 2025 from Medline, Scopus, and Web of Science databases. They screened titles and abstracts, retrieving full texts of original studies to identify key concepts and findings regarding the quorum sensing of <i>P. gingivalis</i> in oral microbial ecosystems.</p><p><strong>Results: </strong>A total of 205 publications were identified, of which 26 were included in the review. These studies demonstrated quorum sensing of <i>P. gingivalis</i> and other bacteria through signal molecules Autoinducer-1 and Autoinducer-2. Autoinducer-1 enhances the pathogenicity of <i>P. gingivalis</i>, facilitating its integration into complex oral microbial communities. Autoinducer-2 fosters cooperative or competitive relationships between <i>P. gingivalis</i> and other periodontal pathogens, modifying the structure of oral biofilms. Additionally, researchers are studying the use of quorum sensing inhibitors to reduce the virulence of <i>P. gingivalis</i> for managing periodontitis and restoring microbial balance in the oral cavity.</p><p><strong>Conclusion: </strong>Quorum sensing enhances the pathogenicity of <i>P. gingivalis</i> in the oral environment. Through the modulation of Autoinducer-1 and Autoinducer-2, quorum sensing regulates interactions between <i>P. gingivalis</i> and other oral microbes. This study demonstrates the need for further research into quorum sensing-targeted interventions in periodontal therapy.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1573863"},"PeriodicalIF":3.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolutionary conformation model of salivary gland lithiasis.","authors":"Álvaro Sánchez Barrueco, María Victoria López-Acevedo Cornejo, William Aragonés Sanzen-Baker, Sol López-Andrés, Gonzalo Díaz Tapia, Ignacio Alcalá Rueda, Jessica Mireya Santillán Coello, Carlos Cenjor Español, José Miguel Villacampa Aubá","doi":"10.3389/froh.2025.1610977","DOIUrl":"10.3389/froh.2025.1610977","url":null,"abstract":"<p><strong>Introduction: </strong>Salivary stones, or sialoliths, are calcified concretions forming within salivary glands and their ducts through a two-stage process: an initial formation of a central core via precipitation of inorganic material mediated by organic substances, followed by layering of additional organic and inorganic material. Substrates for sialolith formation include mucoid agglomerates, organic vesicles, foreign bodies, and bacterial biofilms. Understanding the detailed structure of sialoliths may aid in developing specific preventive or therapeutic strategies.</p><p><strong>Materials and methods: </strong>This study analyzed 137 sialoliths from 102 patients treated across three university hospitals. Stones were extracted via sialendoscopy, direct extraction, or spontaneous extrusion. Structural and compositional analyses were conducted using scanning electron microscopy (SEM-EDX) and x-ray diffraction (XRD).</p><p><strong>Results: </strong>Most sialoliths were from the submandibular gland (82%), with the remainder from the parotid gland (18%). Parotid stones predominantly exhibited irregular shapes, while submandibular stones were generally ellipsoidal. All stones demonstrated an oolitic structure characterized by a central core surrounded by concentric layers and frequently associated with bacteria. Mineral composition predominantly included octacalcium phosphate (OCP), hydroxyapatite, and whitlockite. Larger sialoliths exhibited a higher proportion of hydroxyapatite, indicating increased crystallinity compared to OCP.</p><p><strong>Discussion: </strong>Despite diverse origins and locations, sialoliths share common morphological and compositional traits. Their formation begins with heterogeneous nucleation of calcium phosphates around organic spherules, likely induced by bacterial biofilms. These initial nuclei aggregate into a central core upon which additional layers of organic and inorganic materials deposit progressively. This layering increases the size and crystallinity of the sialoliths over time. The coexistence of amorphous phases and structural heterogeneity within layers explains the variability among stones. Detailed SEM-EDX analysis supports a unified conformational model for sialoliths that integrates the interplay of organic substrates, inorganic minerals, bacterial biofilms, and temporal factors.</p><p><strong>Conclusions: </strong>Sialoliths are oolitic aggregates featuring a central core surrounded by concentric layers composed of organic and inorganic materials. Their formation process involves initial heterogeneous nucleation, bacterial influence, and progressive crystallization. This universal conformational model effectively describes sialolith formation irrespective of patient-specific or anatomical variations.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1610977"},"PeriodicalIF":3.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The association between oral health and mental health.","authors":"Jing Kang, Huabin Luo, Jianhua Wu","doi":"10.3389/froh.2025.1610146","DOIUrl":"10.3389/froh.2025.1610146","url":null,"abstract":"","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1610146"},"PeriodicalIF":3.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effectiveness of diode laser, fluoride varnish, and their combination in treatment of dentin hypersensitivity: a systematic review of randomized clinical trials.","authors":"Manijeh Mohammadian, Nima Jalouti, Mohsen Yazdanian, Elham Keykha, Samira Hajisadeghi","doi":"10.3389/froh.2025.1550127","DOIUrl":"10.3389/froh.2025.1550127","url":null,"abstract":"<p><strong>Background and aim: </strong>Dentin hypersensitivity (DH) has long been a challenging condition, with many treatment methods showing limited success. However, the emergence of laser therapy, particularly the significant potential of diode laser (DL) and sodium fluoride (NaF) varnish, has sparked new hope. This research is a significant step towards a more effective treatment for DH, aiming to evaluate the promising potential of DL in treating DH, both independently and in combination with fluoride varnish. By delving into this research, you are investing your time in understanding a crucial advancement in the field of dentistry.</p><p><strong>Methods: </strong>A comprehensive search was conducted across the PubMed, Scopus, and Web of Science databases, including studies published up until May 2024. Randomized clinical trials that assessed DH using a visual analog scale (VAS) score were included. Data on participant demographics, treatment types, and VAS scores were extracted by two reviewers. The risk of bias was assessed using the revised Cochrane risk-of-bias instrument for randomized trials (RoB-2).</p><p><strong>Result: </strong>Three studies met the inclusion criteria, comparing NaF varnish, DL, and their combination. Both DL and the combination of DL and NaF varnish were more effective than NaF varnish alone in reducing DH. The combined treatment showed marginally superior outcomes compared to DL alone. Significant reductions in DH were observed across all treatment groups, with the combination therapy demonstrating the most substantial and consistent improvement.</p><p><strong>Conclusion: </strong>Diode laser therapy, particularly when combined with NaF varnish, represents a promising treatment approach for DH, offering superior efficacy over NaF varnish alone. These findings suggest that combination therapy may provide longer-lasting relief, with implications for improving clinical outcomes in DH management.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1550127"},"PeriodicalIF":3.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the completeness of electronic health records in dental education: a big data study.","authors":"Tamanna Tiwari, Maxim Kondratenko, Nihmath Nasiha, Toan Ong, Sangeetha Chandrasekaran, Gary Kostbade, Zachary Giano","doi":"10.3389/froh.2025.1535164","DOIUrl":"10.3389/froh.2025.1535164","url":null,"abstract":"<p><strong>Objectives: </strong>The BigMouth Dental Data Repository is an oral health database developed from de-identified electronic health record (EHR) data from eleven dental schools within the United States. To better understand how this database can be used for further research, the repository must be analyzed for data quality, such as accuracy, consistency, and completeness. This study determined the completeness of all patient health records between 2017 and 2019, including demographic, dental, behavioral, and health history variables at the students, faculty, and resident level.</p><p><strong>Methods: </strong>This study analyzed demographic (age, gender, race/ethnicity, zip code, insurance), dental (pain ratings), behavioral (tobacco, alcohol, and drug use), and health history variables for completeness. ANOVA was conducted to detect differences in providers collecting data by year (using Tukey <i>post hoc</i> differences at <i>p</i> < .05). Effect sizes are presented by comparing students to all other provider types.</p><p><strong>Results: </strong>Overall, the data showed high completeness in demographic variables (97.6%-99.9% for age, gender, and zip code) among the total sample of 543,363 patient visits. However, lower completeness rates were found in dental and behavioral variables (ranging from 1.5% to 66.1%), suggesting potential limitations for certain research applications. The study found significant differences in the completeness of records between students, faculty, and residents. In demographic variables, students demonstrated significantly higher completeness rates than faculty across the years 2017-2019, with 79.8%, 79%, and 78.8% completeness for race/ethnicity records, respectively. Furthermore, residents and faculty exhibited significantly higher completeness rates (76.8% and 86.7%, respectively) in insurance information compared to students (56.7%). Notably, students showcased greater completeness percentages in variables related to tobacco use, alcohol use, drug use, and health history compared to both faculty and residents.</p><p><strong>Conclusion: </strong>This study underscores significant variations in the completeness of EHR data among students, faculty, and residents across different schools. Despite these variances, the overall findings suggest a robust level of completeness in the demographic and health variables within the dataset.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1535164"},"PeriodicalIF":3.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conventional scan body vs. scan bodies with auxiliary geometric devices: an <i>in vitro</i> study for edentulous full-arch implant impressions.","authors":"Francesco Gianfreda, Carlo Raffone, Mirko Martelli, Alberto Pitino, Vito Carlo Alberto Caponio, Patrizio Bollero","doi":"10.3389/froh.2025.1574149","DOIUrl":"10.3389/froh.2025.1574149","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to assess the effectiveness of an auxiliary geometric device (AGD) in enhancing the trueness of full-arch implant impressions. The primary metrics of interest were total surface deviation (TotRMS), centroid deviation (cRMS), and angular deviation. All these values are crucial for achieving a precise fit of implant-supported prostheses.</p><p><strong>Methods: </strong>A gypsum-based edentulous maxillary model with four multi-unit abutment replicas was prepared, replicating clinical scenarios. Control and experimental scan bodies were scanned using an intraoral scanner (Dexis 3800), and the resulting data were compared to a digital master model created with a structured light scanner (ATOS compact Scan 5M). The AGD was used to reduce positional errors during the scan process. Data were processed using Exocad and GOM Inspect Professional software, aligning scan body library files with mesh data using a best-fit algorithm. Angular, platform, and total deviations were calculated to assess positional trueness. A sample size of 20 scans per group was determined <i>a priori</i>, and statistical comparisons were made using Mann-Whitney <i>U</i> tests.</p><p><strong>Results: </strong>The inclusion of the AGD significantly reduced centroid root mean square (cRMS) values in all measured comparisons (<i>p</i> < 0.001), demonstrating enhanced trueness. The total body root mean square deviation <b>(</b>TotRMS) values also showed a significant reduction (<i>p</i> = 0.002). While overall angular deviation differences were not statistically significant (meanAGD = 0.38; meanNO = 0.39; where \"NO\" refers to the group without AGD), site-specific analysis revealed significant improvements at points 2.4 (<i>p</i> = 0.017) and 1.4 (<i>p</i> < 0.001). The Euclidean distance in platform deviation consistently indicated better alignment in the AGD group.</p><p><strong>Conclusion: </strong>The AGD, tested under <i>in vitro</i> conditions, significantly improved the trueness of full-arch implant impressions, particularly reducing c- and TotRMS values. These findings highlight the AGD's potential to enhance digital workflows in implant dentistry by mitigating positional discrepancies and ensuring greater trueness and precision. Future research should explore these findings in a clinical scenario.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1574149"},"PeriodicalIF":3.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of a carbonated beverage on the optical properties and microhardness of preheated bulk-fill composite resin restorations.","authors":"Nancy Soliman Farghal, Ayya Abu Shamleh, Osamah Al Hurmuzi, Okba Mahmoud","doi":"10.3389/froh.2025.1539527","DOIUrl":"10.3389/froh.2025.1539527","url":null,"abstract":"<p><strong>Introduction: </strong>Preheating the high-viscosity forms of bulk-fill resin composites is recommended to enhance their flow and adaptability. Nevertheless, the impact of preheating on their characteristics upon exposure to carbonated beverages remains unclear. This study aims to evaluate the effect of a Cola beverage on the properties of preheated and non-preheated high-viscosity bulk-fill composite resins <i>in vitro</i>.</p><p><strong>Methods: </strong>Forty disc-shaped specimens were prepared from each of BEAUTIFIL-Bulk Restorative (BB) and Filtek One Bulk-fill (FOB) composite resin, then divided into two groups (<i>n</i> = 20), either preheated to 68°C for 15 min or kept at room temperature before polymerization, then specimens were immersed in Alkozay Cola beverage for 30 days (3 periods of 15 min/day). Color stability (ΔE₀₀), surface gloss (GU) and Vickers Microhardness (VHN) were recorded before and after the Cola immersion. The data was analyzed with Two-way ANOVA, Three-way ANOVA and Tukey's HSD <i>post hoc</i> test using SPSS software at 95% significance level.</p><p><strong>Results: </strong>The color change was significantly higher in BB than FOB in all groups (<i>P</i> < 0:001), FOB had a significant reduction in color change after preheating (<i>P</i> < 0.05) while BB had no significant change (<i>P</i> > 0.05). Preheating significantly increased the gloss of BB and reduced that of FOB (<i>P</i> < 0.001), however, Cola beverage significantly reduced the gloss of all the groups (<i>P</i> < 0.001). Preheating significantly increased the microhardness of both materials (<i>P</i> < 0.001), however, Cola beverage significantly reduced the microhardness of all the groups (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Although the preheating of high-viscosity bulk-fill composites significantly improved their microhardness and improved the surface gloss of FOB, it did not protect both composites against the Cola drink attack. Preheated FOB showed improved color stability after the Cola immersion, but not to a clinically acceptable limit.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1539527"},"PeriodicalIF":3.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric and visualization analysis of temporomandibular joint osteoarthritis from 2004 to 2024.","authors":"Chi Xu, Chongqing Yu, Tao Wang, Xiang Gao","doi":"10.3389/froh.2025.1596551","DOIUrl":"10.3389/froh.2025.1596551","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular joint osteoarthritis (TMJOA) is a severe condition affecting the temporomandibular joint, impairing essential oral functions such as chewing, speaking, and swallowing. Recent studies have made significant outcomes in pathogenesis, clinical symptoms, and therapy in the field of TMJOA. However, knowledge of research trends and hotspots of TMJOA is still lacking in this field. This study conducted a bibliometric analysis of TMJOA, providing a comprehensive overview of current research hotspots and trends.</p><p><strong>Methods: </strong>A total of 584 TMJOA-related records published between 2004 and 2024 were retrieved from the Web of Science Core Collection (WoSCC) database. VOSviewer, CiteSpace, the R package \"bibliometrix\", and the Bibliometric website were used to analyze countries, institutions, journals, authors, and keywords to identify research trends in TMJOA.</p><p><strong>Results: </strong>Publications on TMJOA have shown a steady annual increase. Globally, China and the USA emerged as the leading contributors, accounting for over 60% of the publications. Sichuan University ranked first in total publications and citations, while the University of Northern Carolina led in average citations. The <i>Journal of Oral Rehabilitation</i> published the most studies, whereas the <i>Journal of Dental Research</i> had the highest impact factor (5.3) and H-index (158). Long X was the most prolific author, while Liu Y, Manfredini D, and Guarda-Narnini L were the top-cited authors with the highest H-indices. Keyword analysis revealed four primary research clusters: \"pathogenesis mechanisms\", \"clinical manifestations\", \"regeneration research\", and \"therapy research\".</p><p><strong>Conclusion: </strong>This bibliometric analysis highlights publication trends, research hotspots, citation patterns, and collaborative networks among countries, institutions, and authors in the TMJOA field. Future research is expected to focus on molecular signaling pathways and targeted therapies for TMJOA, with the ultimate goal of accelerating translational research to enhance clinical outcomes for patients.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1596551"},"PeriodicalIF":3.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}