Frontiers in oral health最新文献

{"title":"Dental service for United Nations peacekeepers coping with COVID-19 in Bukavu: preparation, implementation and recommendation.","authors":"Shuai Lu, Li Miao, Yong He, Jia-Ning Luo, Lu Lin, Zhi-Hua Liu, Bi-Yu Yan, Jia-Ling Wu, Yang Xie, Shu-Yong Yang, Chao Wang","doi":"10.3389/froh.2025.1527777","DOIUrl":"10.3389/froh.2025.1527777","url":null,"abstract":"<p><strong>Background: </strong>The Chinese level 2 hospital (CHH L2) deployed in Bukavu provides medical supports to peacekeepers in MONUSCO. This study aimed to statistically analyze the types of oral and maxillofacial problems and corresponding treatments provided from October 2018 to September 2022, and to describe the trends of dental service pre and post COVID-19 outbreak.</p><p><strong>Methods: </strong>The medical records of all patients visited to the CHN L2 during the 48 months were collected and were accessed for the research purposes between October 2018 and September 2022. Dental visitors were counted and identified with nationality and occupations. Dental service was categorized as emergency, routine and evacuation. Diagnosis and treatments provided were statistically analyzed.</p><p><strong>Results: </strong>952/3,913 (24.33%) of the visitors to CHN L2 during this period were referred to dentistry, including 50 females (5.25%) and 902 males (94.75%). The proportion of UN military personnel is 91.39% (870/952). A total of 1,116 teeth and mucosa problems were treated. Dental emergencies represented 13.98% percent (156/1, 116). 2,180 dental treatments (2.29 procedures per patient) were provided: dental radiographs taken (618, 28.30%), local anesthesia (448, 20.55%), RCT (373, 15.14%), resin composite filling (330, 15.14%), extraction (248, 11.38%) and other treatments (164, 7.52%). The number of monthly visitors was significantly affected by the COVID-19 epidemic (<i>p</i> < 0.05), pre-COVID-19 (total 151 ± 51, dental 33 ± 13) and post-COVID-19 (total 51 ± 21, dental 13 ± 8), the lowest number was in July 2020, 6 months after the COVID-19 outbreak (total 16 and dental 3).</p><p><strong>Conclusions: </strong>Dentistry is the most frequently visited department in the CHH L2 in Bukavu, and the number of visitors were affected by the COVID-19 epidemic. Treatments related to dental caries, pulpitis, apical periodontitis, and wisdom teeth problems account for the majority of dental service. The variety and severity of dental problems demonstrate the urgent need for training in multiple specialized skills for deployed military dental personnel.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1527777"},"PeriodicalIF":3.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultural practices, oral health service utilisation and oral health policy and guidelines development in Africa: insights from the yorùbá ethnic group.","authors":"Moréniké Oluwátóyìn Foláyan, Oluwabunmi Tope Bernard, Olusegun Stephen Titus, Omolola Alade, Taofeek Kolawole Aliyu, Ahmed Bhayat, Nicaise Ndembi, Gbenga Fasiku, Maha El Tantawi","doi":"10.3389/froh.2025.1539827","DOIUrl":"10.3389/froh.2025.1539827","url":null,"abstract":"<p><p>Cultural beliefs and practices influence oral health behaviors in Africa, where traditions around health are deeply woven into daily life and community values. From the symbolism embedded in African art, belief in efficacy of herbs and natural elements, to the communal customs around oral hygiene, culture serves as a lens through which health beliefs and practices related to oral health are cultivated, understood and acted upon. This manuscript discusses rituals and embodied culture practices surrounding oral health among yorùbá, and links this discussion to the implications for oral health policies and interventions in Africa. Yorùbá is a prominent ethnic group in West Africa with oral traditional practices which reflect the community's emphasis on natural remedies, often reducing reliance on professional dental care. Through an analysis of oral health \"rituals\" embedded in yorùbá songs, proverbs, and Ifá divination poetry, this manuscript argues that cultural expressions reinforce the importance of oral health as a manifestation of spiritual balance and personal oral hygiene. Despite this cultural reverence, the manuscript finds that dental service utilization remains low among the yorùbá, with spiritual and traditional interpretations of oral health concerns often delaying professional intervention. It further suggests that integrating culturally resonant strategies into oral health policies could bridge gaps in service uptake. By analyzing these dynamics, the study offers a culturally informed perspective on oral health research and proposes policy frameworks that integrate indigenous and modern health approaches.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1539827"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Embedding current trends and innovative pedagogies in education in oral health: advancing educational practices and research.","authors":"Melanie Nasseripour, Angelo Leone, Ana Angelova Volponi, Bo Danielsen, Jonathan San Diego, Ana Estela Haddad","doi":"10.3389/froh.2025.1569865","DOIUrl":"https://doi.org/10.3389/froh.2025.1569865","url":null,"abstract":"","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1569865"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Brons-Mulié analysis as a decision-making tool for preoperative surgical simulation in orthognatic surgery.","authors":"Sebastian Böttger, Yannick Nowak, Anita Cornelia Windhorst, Katharina Klaus, Sabine Ruf, Christina Bäcker, Eva May Schraml, Nina Danevitch, Rob Mulié, Hans-Peter Howaldt, Sameh Attia","doi":"10.3389/froh.2025.1511342","DOIUrl":"10.3389/froh.2025.1511342","url":null,"abstract":"<p><strong>Objectives: </strong>Sufficient preoperative planning represents an essential component for the success of orthognathic surgery. Using various analysis methods, dysmorphic areas can be reliably identified and addressed during the planning procedure.</p><p><strong>Methods: </strong>Brons-Mulié analysis was used to examine profile photographs before and after orthognathic surgery. The attainment of normal values was interpreted as the achievement of facial harmony of the various facial proportions. By comparing the pre- and postoperative analysis, a control of the outcome quality of the orthognathic procedures was performed.</p><p><strong>Results: </strong>In a total of 160 patients aged 13 to 61 years, the preoperative analysis could be compared with the postoperative Brons-Mulié analysis. Postoperative, facial harmony was found for the vertical dimension in 99 cases (62%), for the upper lip dimension in 95 cases (59%), for the lower lip dimension in 138 cases (86%), and for the chin dimension in 118 cases (74%). This corresponded to an improvement of 20% in the vertical dimension, of 27% in the area of the lower lip and of 6% in the area of the chin. The upper lip area showed a slight deterioration of 7%.</p><p><strong>Conclusion: </strong>Despite preoperative planning of orthognathic surgery with Brons-Mulié analysis, postoperative results show an overall improvement but not perfection. Even by applying the method, it remains a challenge to achieve perfect facial harmony.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1511342"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of salivary matrix metalloproteinase (MMP8) and activated salivary matrix metalloproteinase (aMMP8) in periodontitis patients: a systematic review and meta-analysis.","authors":"Sean G Boynes, Nigar Sofiyeva, Tina Saw, Valerie Nieto, Leena Palomo","doi":"10.3389/froh.2025.1444399","DOIUrl":"10.3389/froh.2025.1444399","url":null,"abstract":"<p><strong>Introduction: </strong>Periodontitis affects a significant portion of the global population and is associated with systemic health issues. Salivary biomarkers such as salivary matrix metalloproteinase-8 (MMP-8) and its activated form (aMMP-8) have been studied for their roles in tissue degradation and inflammation in periodontitis. This meta-analysis investigates the association between salivary MMP-8 and aMMP-8 levels and periodontitis.</p><p><strong>Methods: </strong>A systematic literature search was conducted utilizing PubMed, Embase, Web of Science, and Cochrane Library databases up to October 2023, yielding 35 studies that quantified MMP-8 or aMMP-8 in saliva from patients with periodontitis and healthy controls. Data were extracted, and standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated. Heterogeneity was assessed, and subgroup analyses were performed based on saliva collection techniques. Meta-regression analysis evaluated the impact of publication year on heterogeneity.</p><p><strong>Results: </strong>The meta-analysis included 35 studies. Pooled results indicated significantly higher levels of MMP-8 and aMMP-8 in periodontitis cases compared to healthy controls (SMD: 2.71, 95% CI: 1.04-4.38, <i>p</i> = 0.002) with substantial heterogeneity (I² = 94.5%). No significant difference was found between MMP-8 and aMMP-8 (<i>p</i> = 0.445). Subgroup analyses by saliva collection technique did not reduce heterogeneity significantly. Meta-regression showed that publication year did not impact heterogeneity. Small-study effects and publication bias were present, suggesting caution in interpreting the results.</p><p><strong>Discussion: </strong>The findings support the potential of MMP-8 and aMMP-8 as biomarkers for periodontitis, although substantial heterogeneity and methodological differences among studies pose challenges. Standardized protocols and larger sample sizes are necessary to enhance the reliability of these biomarkers in clinical practice. Despite limitations, salivary diagnostics hold promise for non-invasive, early detection and monitoring of periodontitis.</p><p><strong>Conclusion: </strong>Salivary MMP-8 and aMMP-8 levels are significantly associated with periodontitis, highlighting their potential as diagnostic biomarkers. However, methodological improvements and standardization are essential for their clinical application. Collaborative efforts and advancements in salivary diagnostics are crucial for improving periodontitis management and patient outcomes.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1444399"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the correlation of epidemiological and clinical factors with facial injury severity scores in maxillofacial trauma: a comprehensive analysis.","authors":"Weronika Michalik, Julia Toppich, Adam Łuksza, Jakub Bargiel, Krzysztof Gąsiorowski, Tomasz Marecik, Paweł Szczurowski, Grażyna Wyszyńska-Pawelec, Michał Gontarz","doi":"10.3389/froh.2025.1532133","DOIUrl":"10.3389/froh.2025.1532133","url":null,"abstract":"<p><strong>Introduction: </strong>The Facial Injury Severity Scale (FISS) provides a numerical value based on individual fractures that can be a valuable tool for management of maxillofacial trauma patients. The aim of this study was to evaluate the association of epidemiological and clinical factors with facial fracture patterns and their correlations with FISS.</p><p><strong>Methods: </strong>A retrospective study was conducted based on 511 medical records from a 4-year period of patients with facial trauma who underwent open reduction internal fixation (ORIF) under general anesthesia. Fracture patterns were categorized into 3 anatomic subunits: upper, middle and lower face. Single-unit and panfacial fractures groups were analyzed separately. Data regarding demographics, hospitalization, etiology of injury, fracture site and complications were collected. The overall risk of fracture within the viscerocranium requiring an ORIF was presented in graphical form.</p><p><strong>Results: </strong>Single-unit fractures were more typical in younger patients. There was a significant association between FISS score and traumatic etiology, hospitalization time, length of surgery in each group (<i>p</i> < 0.001). For panfacial fractures, FISS >6 indicated prolonged surgery (>2 h) and hospitalization (>1 week).</p><p><strong>Discussion: </strong>Despite the questionable clinical utility of FISS, classifying maxillofacial trauma can facilitate comprehensive treatment planning and multidisciplinary collaboration, particularly in complex cases such as panfacial fractures.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1532133"},"PeriodicalIF":3.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-produced radiographic enhancements in dental clinical care: provider and patient perspectives.","authors":"Lyubov D Slashcheva, Kelly Schroeder, Lisa J Heaton, Hannah J Cheung, Brenda Prosa, Nicole Ferrian, Jesse Grantz, Deborah Jacobi, John J O'Malley, Michael Helgeson, Eric P Tranby","doi":"10.3389/froh.2025.1473877","DOIUrl":"https://doi.org/10.3389/froh.2025.1473877","url":null,"abstract":"<p><strong>Introduction: </strong>Artificial intelligence (AI)-based software can be used with dental radiographs to facilitate dental providers' diagnoses and to educate patients about their oral health conditions. The goal of this study was to survey dental providers and patients about the use of AI-enhanced radiographs in the diagnostic and patient education processes.</p><p><strong>Methods: </strong>Within their Community Collaborative Practice model, Apple Tree Dental in Minnesota implemented the use of an AI software platform that annotates carious lesions and periodontal measurements on dental radiographs. Before and after implementation of this software, providers (dentists, dental hygienists, dental therapists, and dental assistants) were surveyed about what benefits and challenges they anticipated and experienced in using the AI software. A small-scale study of patients who viewed AI-generated annotations on their own radiographs examined patient perspectives on the use of this software.</p><p><strong>Results: </strong>Dental therapists reported using the software most often, with 57.2% using the software at least 50% of their clinical time; 79% of dental assistants reported using the software 25% of the time or less. While the majority of providers (<i>n</i> = 70 for Survey I; <i>n</i> = 53 for Survey II) said that AI enhancements would help facilitate patient education efforts, providers' confidence in the ability of the AI software to improve diagnosis of dental caries and periodontal disease and its ability to improve the efficiency of their work was mixed. Patients (<i>n</i> = 25) found reviewing the AI-produced visual aids used by their dental provider to be helpful in understanding their oral health, and a large proportion (92%) said they planned to follow through on recommended treatment.</p><p><strong>Discussion: </strong>While provider and patient perceptions of the use of AI software in dental care were positive overall, attitudes among providers were mixed regarding its effectiveness in diagnosing dental disease and improving work efficiency. More research is needed to determine whether use of AI software in clinical dental practice produces changes in treatment recommendations by providers or in patient adherence to these recommendations.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1473877"},"PeriodicalIF":3.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher Reactive Oxygen Species and cellular aging in oral mucosal cells of young smokers: a comparative analytical study.","authors":"Bushra Imdad, Uzair Abbas, Pershad Kumar, Durre Sameen Kamran, Mahtab Khan, Niaz Hussain, Muhib Ullah Khalid","doi":"10.3389/froh.2025.1372494","DOIUrl":"https://doi.org/10.3389/froh.2025.1372494","url":null,"abstract":"<p><strong>Background: </strong>Cigarette smoke contains chemical components that cause excessive production of Reactive Oxygen Species (ROS), altering cell physiology and affecting key pathways. This leads to hyperinflammation, DNA damage, and cellular aging, which may cause oral and pulmonary pathologies. Our study aims to investigate the impact of smoking on ROS levels and cellular aging in oral mucosal cells. We compared Reactive oxygen Species and cellular aging between smokers and non-smokers. Secondarily, we also compared the results between young and old smokers.</p><p><strong>Methods: </strong>Oral swabs were taken from 50 smokers and 50 nonsmokers using a cytology brush. We quantified the reactive oxygen species (ROS) by using oxidized 2'7' dichlorodihydrofluorescein-diacetate (DCFH-DA) dye. To assess cellular aging, mRNA levels of the CYR61 gene-a cellular aging marker, were compared through RT-PCR.</p><p><strong>Results: </strong>It was found that smokers had a higher percentage of ROS in comparison to non-smokers (<i>p</i> value < 0.001). Additionally, there was an over-expression of the CYR61 gene in smokers as compared to non-smokers (<i>p</i> value = 0.001). Furthermore, when comparing ROS and cellular aging between young smokers and old smokers, it was noted that there was a significantly higher percentage of ROS and up-regulation of mRNA levels of CYR61 gene in young smokers in comparison to old smokers (<i>p</i> value 0.001 and <0.0001 respectively).</p><p><strong>Conclusion: </strong>It has been observed that smokers have a higher amount of ROS production and cellular aging in their oral mucosal cells. In young smokers, ROS and cellular aging were found to be higher compared to older smokers. This is quite concerning and could be a major factor leading to oral pathologies in smokers.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1372494"},"PeriodicalIF":3.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sports dentistry intricacies with season-related challenges and the role of athlete-centered outcomes.","authors":"André Júdice, João Botelho, Vanessa Machado, Luís Proença, Luciano M A Ferreira, Peter Fine, José João Mendes","doi":"10.3389/froh.2025.1531653","DOIUrl":"10.3389/froh.2025.1531653","url":null,"abstract":"<p><p>Sports dentistry is an emerging field focusing on the prevention, treatment, and management of oral health issues in athletes. This review critically examines the current state of sports dentistry, emphasizing the integration of oral health care into athletes' overall health management. The high prevalence of dental caries, erosion, and periodontal problems among athletes is linked to diet, habits, and increased risk of orofacial injuries. Routine oral health evaluations, particularly during the preseason, are recommended to tailor prevention strategies and address potential issues early on. The recently proposed Universal Screening Protocol for Dental Examinations in Sports is discussed, noting its potential limitations in terms of time and complexity. The review explores the challenges posed by athletes' demanding training and competition schedules, stressing the importance of incorporating oral health care into the medical team. Future research should investigate the feasibility and validity of self-reported questionnaires for screening oral health conditions, potentially simplifying the process for athletes. The review highlights the use of athlete-reported outcomes and self-reporting in sports dentistry as crucial for evaluating dental care effectiveness and monitoring long-term health outcomes. It concludes by emphasizing the need for streamlined, universally applicable protocols that fit athletes' schedules while providing comprehensive care, and the importance of further research to explore innovative screening tools and self-reported measures to transform routine care practices and reduce barriers to dental health for athletes.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1531653"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yeast cell wall derivatives as a potential strategy for modulating oral microbiota and dental plaque biofilm.","authors":"Torsten P M Scheithauer, Isabela M Fernandes de Oliveira, Michel Ossendrijver, Elodie Dehay, Michelle van der Wurff, Hakim Rahaoui, Nathalie Ballet, Bart J F Keijser","doi":"10.3389/froh.2025.1543667","DOIUrl":"10.3389/froh.2025.1543667","url":null,"abstract":"<p><strong>Introduction: </strong>Derivatives from <i>Saccharomyces cerevisiae</i> yeast including yeast extracts and yeast cell walls are sustainable sources of valuable nutrients, including dietary fibers and proteins. Previous studies have shown that certain components from these yeast derivatives can inhibit the growth of harmful intestinal bacteria and promote the growth of beneficial bacteria. However, the effects of yeast derivatives on oral health have not yet been investigated.</p><p><strong>Methods: </strong>An <i>in vitro</i> oral biofilm model was employed to examine the impacts of yeast derivatives on the oral microbiota and their potential benefits for maintaining oral homeostasis. The model incorporated dental plaque donor material from both healthy and periodontitis diagnosed individuals. Biofilm formation, density, and microbial composition were quantified. Additionally, the production of short-chain fatty acids in the biofilm supernatants was measured.</p><p><strong>Results: </strong>Yeast extracts had only minor effects on oral biofilm formation. In contrast, yeast cell wall derivatives, which are rich in polysaccharides such as beta-glucans and mannans, significantly reduced the density of the oral biofilms <i>in vitro</i>. This reduction in biofilm density was associated with an overall shift in the bacterial community composition, including an increase in beneficial bacteria and a decrease in the abundance of <i>Tannerella forsythia</i>, an important species involved in bacterial coaggregation and the development and maturation of the oral biofilm. Furthermore, the yeast cell wall derivatives decreased the production of short-chain fatty acids, including acetic and butyric acid. These findings were consistent across both healthy and periodontitis microbiomes.</p><p><strong>Conclusion: </strong>This study has demonstrated the potential of yeast cell wall derivatives to positively impact oral health by significantly reducing biofilm density, modulating the oral microbial composition, and decreasing the production of short-chain fatty acids. The observed effects highlight the promising applications of these yeast-based compounds as an approach to managing oral diseases. Further research is needed to fully elucidate the mechanisms of action and explore the clinical potential of yeast cell wall derivatives in promoting and maintaining oral health.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1543667"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}