Frontiers in oral health最新文献

{"title":"Unleashing nature's defense: potent antimicrobial power of plant extracts against oral pathogens and Streptococcus mutans biofilms.","authors":"Joachim Hickl, Aikaterini Argyropoulou, Ali Al-Ahmad, Elmar Hellwig, Alexios Leandros Skaltsounis, Annette Wittmer, Kirstin Vach, Lamprini Karygianni","doi":"10.3389/froh.2024.1469174","DOIUrl":"10.3389/froh.2024.1469174","url":null,"abstract":"<p><strong>Objectives: </strong>The increasing demand for alternatives to antibiotics against resistant bacteria has led to research on natural products. The aim of this study was to analyze the antimicrobial and antibiofilm activity of 16 Mediterranean herb extracts.</p><p><strong>Materials and methods: </strong>The extracts were analyzed using High Performance Thin Layer Chromatography. The minimum inhibitory concentration and minimum bactericidal concentration of the extracts from <i>Achillea taygetea</i>, <i>Cistus creticus</i> ssp. <i>creticus</i>, <i>Cistus monspeliensis</i>, <i>Lavandula stoechas</i>, <i>Mentha aquatica</i>, <i>Mentha longifolia</i>, <i>Origanum vulgare</i>, <i>Phlomis cretica</i>, <i>Rosmarinus officinalis</i>, <i>Salvia sclarea</i>, <i>Satureja parnassica</i>, <i>Satureja thymbra</i>, <i>Sideritis euboea</i>, <i>Sideritis syriaca</i>, <i>Stachys spinosa</i>, and <i>Thymus longicaulis</i> were determined against eight oral bacteria and fungus <i>Candida albicans</i>. Microtiter plate test was conducted to evaluate the antibiofilm activity against <i>Streptococcus mutans</i>.</p><p><strong>Results: </strong>Overall, all tested extracts efficiently suppressed the growth of obligate anaerobic bacteria. When applied at concentrations ≥0.15 mg/ml, the extracts exhibited moderate to high antibiofilm activity comparable to that of chlorhexidine (CHX) against <i>S. mutans</i>. Interestingly, <i>R. officinalis</i> (MIC: 0.01-0.06 mg/ml) and <i>O. vulgare</i> (MIC: 0.04-1.25 mg/ml) demonstrated the highest antibacterial activity against oral bacteria. Additionally, <i>R. officinalis</i> and <i>L. stoechas</i> significantly inhibited <i>S. mutans</i> biofilm formation at 0.15 mg/ml.</p><p><strong>Conclusions: </strong>The tested plant extracts can be considered as alternative natural antimicrobial and antibiofilm agents.</p><p><strong>Clinical relevance: </strong>Mediterranean herb extracts show promise as natural alternatives to combat oral bacteria and biofilm formation, offering potential new therapies for infectious oral diseases in the context of antibiotic resistance.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"5 ","pages":"1469174"},"PeriodicalIF":3.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The future of third molar surgery.","authors":"Ievgen I Fesenko, João Luiz Gomes Carneiro Monteiro","doi":"10.3389/froh.2024.1512305","DOIUrl":"10.3389/froh.2024.1512305","url":null,"abstract":"","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"5 ","pages":"1512305"},"PeriodicalIF":3.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internal and marginal fits of 3D-printed provisional prostheses: comparative effect of different printing parameters.","authors":"Yousif A Al-Dulaijan, Rand Aldamanhori, Hadeel Algaoud, Rand Alshubaili, Reem Alkhateeb, Haidar Alalawi, Reem Abualsaud, Firas K Alqarawi, Faisal D Al-Qarni, Mohammed M Gad","doi":"10.3389/froh.2024.1491984","DOIUrl":"10.3389/froh.2024.1491984","url":null,"abstract":"<p><strong>Objectives: </strong>The influence of printing parameters on the marginal and internal fit of three-dimensional (3D) printed interim fixed partial dentures (IFPDs) has been understudied. This investigation sought to elucidate the impact of printing orientation and post-curing time on these critical factors.</p><p><strong>Methods: </strong>A total of 260 3-Unit IFDPs were printed using two different resins (130/NextDent C&B MFH and 130/ASIGA DentaTOOTH). For each material, specimens were printed with three different angulations (0-, 45-, and 90-degree in relation to the z-axis). Each was further divided into 4 groups (<i>n</i> = 10) according to post-curing time (30-, 60-, 90-, and 120 min), while the green state (GS) group at 0-degree remained without post-curing as a control. Each specimen was scanned and then superimposed on the original CAD file. The marginal and internal fit of premolar and molar restorations were evaluated using the silicone replica technique. Digital scanning of the master die, both with and without a fit checker, was followed by data superimposition to compare the master die with the fit checker of each sample. 3D comparisons were conducted using initial and best-fit alignment methods, and the root mean square error (RMS) was calculated to quantify marginal and internal fit at each abutment and for the overall restoration. Statistical analysis was performed using JMP® software (JMP®, Version 16, SAS Institute Inc., Cary, NC, USA, 1989-2022) with a significance level 0.05 for all tests.</p><p><strong>Results: </strong>For the ASIGA group, 0-degree orientation generally exhibited better fit than 45- and 90-degree orientations, with some variations based on post-cure time. For marginal fit, ASIGA crowns typically showed better results with 90-degree orientation, while NextDent crowns demonstrated consistent performance across orientations. Post-curing time also influenced marginal fit, with longer durations generally resulting in improved outcomes.</p><p><strong>Conclusion: </strong>With different printing orientations and post-curing times, ASIGA and NextDent resins can produce IFDPs with acceptable internal and marginal fit. However, NextDent resin consistently outperformed ASIGA in terms of overall fit. Further research is needed to evaluate the long-term clinical performance of these materials.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"5 ","pages":"1491984"},"PeriodicalIF":3.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotations of teeth-a systematic review.","authors":"Ramya Parthiban, Vignesh Kailasam, Nivetha Shree Venkatasamy","doi":"10.3389/froh.2024.1484020","DOIUrl":"10.3389/froh.2024.1484020","url":null,"abstract":"<p><strong>Background: </strong>Rotations are frequently evaluated through various assessment methods of crowding and arch dimension, with relatively few studies discussing the extent or direction of rotations and even fewer addressing the reliability of such assessments. This systematic review aims to comprehensively analyze existing classification systems for rotated teeth and assess rotation in anterior and posterior teeth, its clinical applicability, and its impact on retention and relapse.</p><p><strong>Search methods: </strong>Two investigators conducted a comprehensive search in six databases, namely, PubMed, Scopus, Ovid, LILACS, Web of Science, and Cochrane CENTRAL, up to 28 March 2024. No specific start date was defined to ensure the inclusion of all relevant studies from the inception of each database, maximizing the comprehensiveness of our review. The search criteria included retrospective studies and the inclusion criteria were patients who were assessed for rotation in any age group. The exclusion criteria were patients who had undergone orthodontic treatment, who had fractured restorations or crowns, or who had any other tooth anomaly.</p><p><strong>Data collection and analysis: </strong>In total, 10 studies satisfying the inclusion criteria were included and 9 provided quantitative outcomes for the rotation of various teeth, while the remaining study offered qualitative results. The risk of bias assessment was performed with the help of the Newcastle-Ottawa quality assessment tool.</p><p><strong>Results: </strong>The skeletal Class II and Class III groups exhibited similar average positions of the first molar. Upper molar rotation was primarily observed in dental Class II patients, with a higher mesial rotation angle of 78.6°. Only one study measured the rotation for all permanent teeth. Seven studies used the mid-palatal raphe as the reference line for measuring molar rotation. No gender differences were found. It was found that there was no statistical significance in the mean values of molar rotation for the right and left sides as well as the maxillary and mandibular arches. The incisors demonstrated the highest degree of rotation (7.4°-20.2°), while the premolars and canines exhibited a slightly lower degree of rotation (3.3°-9.2°). In contrast, the molars displayed the lowest degree of rotation (0.8°-7.4°).</p><p><strong>Conclusion: </strong>After reviewing all the studies, it was found that there is no adequate classification system to assess the rotation of anterior teeth and mandibular teeth. A universally accepted classification of tooth rotation, including a common reference line, is needed. The existing systems for posterior teeth need to be standardized and have a clinical utility to be widely accepted.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024524654, PROSPERO (CRD42024524654).</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"5 ","pages":"1484020"},"PeriodicalIF":3.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in taste perception in elderly population and its potential impact on oral health: a systematic review with meta-analysis.","authors":"Larisse Santos Mendonça Alves, Júlia Maria de Sousa Munduri, Mariana Caldas de Oliveira Mattos, Cristine Miron Stefani, Naile Dame-Teixeira","doi":"10.3389/froh.2024.1517913","DOIUrl":"10.3389/froh.2024.1517913","url":null,"abstract":"<p><strong>Aim: </strong>Gustatory function plays a fundamental role in various aspects related to nutrition and health, and the decline in taste perception can result in a series of adverse consequences. This is expected with aging due to a decrease in taste buds and other conditions, leading to systemic and oral diseases. We aimed to compare taste sensitivity in the elderly population vs. adults.</p><p><strong>Methods: </strong>This systematic review was reported according to PRISMA guidelines. The search was performed in four databases, as well as in grey literature. The risk of bias was assessed using the JBI's critical appraisal tools for observational studies. A meta-analysis with subgroups according to each flavor was conducted to obtain differences in means for adults vs. elderly (random-effects model).</p><p><strong>Results: </strong>Out of the 5,660 studies retrieved, 18 observational studies were included, representing a total of 1,680 aged 18-59 years and 1,048 aged ≥ 60 years. Elderly individuals need higher concentrations to distinguish flavors compared to adults. In a qualitative analysis, all flavors showed differences between the groups, with sweet flavor being the easiest to recognize and the thresholds between the groups not being highly discrepant. However, in the meta-analysis, statistical differences were observed for sweet, salty, and umami flavors, while there were no statistical differences for sour and bitter flavors between the groups.</p><p><strong>Conclusions: </strong>There are significant differences for distinguishing sweet, salty, and umami flavors between adults and elderly. Bitter and sour flavors did not exhibit differences in elderly.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=463873, PROSPERO (CRD42023463873).</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"5 ","pages":"1517913"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silent signals: how <i>N</i>-acyl homoserine lactones drive oral microbial behaviour and health outcomes.","authors":"Zelda Ziyi Zhao, Lifeng Guo, Wenwen Shan, Chun Hung Chu, Jing Zhang","doi":"10.3389/froh.2024.1484005","DOIUrl":"10.3389/froh.2024.1484005","url":null,"abstract":"<p><strong>Background: </strong><i>N</i>-acyl homoserine lactones (AHLs) are small signalling molecules predominantly secreted in Gram-negative bacteria.</p><p><strong>Objective: </strong>The aim is to provide a comprehensive overview of AHLs in oral health.</p><p><strong>Methods: </strong>Two independent researchers conducted a systematic search of English language publications up to 30 June 2024 in PubMed, Scopus and Web of Science. They screened the title and abstract to retrieve and map out relevant studies on AHLs in oral health, in order to identify key concepts, gaps in knowledge, and areas for further research.</p><p><strong>Results: </strong>This study identified 127 articles and included 42 articles. These studies identified AHLs in human oral samples like saliva, dental plaque, tongue swabs, and dentin caries. The studies also found that AHLs regulate cell-to-cell communication of bacteria (quorum sensing) in mature biofilm fostering the production of virulence factors that damage the immune system. AHLs also exert biological effects on human cells and influence oral diseases such as periodontitis and oral squamous carcinoma. Researchers developed AHL inhibitors to interfere with the quorum sensing process and interrupt the communication between bacteria. These inhibitors can be classified into three main categories based on their mechanisms of action to AHLs: AHL synthesis disruptors, AHL competitive inhibitors and AHL enzymatic degraders. These AHL inhibitors can be important tools in the fight against bacterial infections, particularly those caused by Gram-negative bacteria.</p><p><strong>Conclusion: </strong>The literatures indicate that AHLs, as quorum sensing molecules, influence bacterial communication. AHLs have a significant impact in bacterial pathogencity and play a potential role in the pathogenesis of oral diseases. Researchers have developed AHL inhibitors to disrupt bacterial quorum sensing, preventing bacteria from forming biofilms or expressing virulence factors. These studies on AHLs represent a new research direction to develop novel therapeutic strategies to manage oral diseases.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"5 ","pages":"1484005"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of a novel \"all in one glove\"- a functional tool for oral hygiene maintenance and the assessment of its effectiveness on plaque control in spastic cerebral palsy patients.","authors":"Sucharitha Palanisamy, Priyanka Cholan, Harinath Parthasarathy, Anupama Tadepalli","doi":"10.3389/froh.2024.1479684","DOIUrl":"10.3389/froh.2024.1479684","url":null,"abstract":"<p><strong>Background & objective: </strong>Spastic Cerebral Palsy (CP) is a neurological disorder from non-progressive brain injury or malformation during development, severely impairing movement, coordination, reflexes, posture, balance, and motor skills. Individuals with spastic CP experience limb spasticity, complicating tasks like precise gripping, particularly with toothbrushes. This study proposed a novel \"all-in-one glove\" for oral hygiene, assessing its efficacy and comparing it to conventional toothbrushes for spastic CP patients.</p><p><strong>Methods & materials: </strong>This randomized controlled trial was conducted on 30 clinically diagnosed spastic CP patients with Group 1 consisting of 15 Subjects with clinically diagnosed spastic CP with generalized gingival diseases using conventional oral hygiene techniques with weekly oral hygiene reinforcement and Group 2 consisting of 15 Subjects with clinically diagnosed spastic cerebral palsy with generalized gingival diseases using the novel \"all in one glove\" method for oral hygiene maintenance with weekly oral hygiene reinforcement. The Clinical Parameters assessed includes Full mouth plaque scores, Full mouth bleeding scores and OHI scores recorded at baseline, 3 and 6 months.</p><p><strong>Results: </strong>A statistically significant reduction was observed in Full-mouth Plaque, Bleeding, and Oral Hygiene Index (OHI) scores in both the groups (48.87% & 43.285%, 31.57% & 26.66%, 57.29% & 47.37% respectively). The Group 2 exhibited a marginally higher percentage reduction in all clinical parameters compared to the Group 1 at the measured time points.</p><p><strong>Conclusion: </strong>The utilization of the \"All in one glove\" has improved the effectiveness of oral hygiene maintenance and gingival health in spastic CP individuals.</p><p><strong>Clinical trial registration: </strong>[ClinicalTrials.gov], identifier, [REF/2022/06/055641].</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"5 ","pages":"1479684"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of scientific productivity in dentistry: tracking postgraduate publications at a Peruvian university.","authors":"Cesar D Rojas-Senador, María Claudia Garcés-Elías, Roberto A León-Manco","doi":"10.3389/froh.2024.1494435","DOIUrl":"10.3389/froh.2024.1494435","url":null,"abstract":"<p><strong>Introduction: </strong>Scientific production indicators help universities quantitatively and qualitatively assess postgraduate students' publications and contribute to the optimization of research processes. This study aimed to determine the frequency of publication in scientific journals of the documents submitted by postgraduate dentistry students to obtain a second professional specialty title and master's and doctoral degrees at a private Peruvian university over seven years.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted, considering the population and the records of documents submitted to obtain the second professional specialty title and the master's and doctoral degrees in dentistry at a private Peruvian university, published in its institutional repository from 2017 to 2023. The primary outcome was publication in scientific journals, and the covariates were the year of formal submission of the document, postgraduate level, modality of document preparation, area of dentistry specialty according to the American Dental Association, year of publication, international indexing, impact factor (IF), and quartile. A descriptive analysis was performed to obtain absolute and relative frequencies.</p><p><strong>Results: </strong>Between 2017 and 2023, out of 322 documents submitted to receive the second professional specialty title and the master's and doctoral degrees published in the institutional repository, 72 were published in scientific journals. Of these, 81.94% (<i>n</i> = 59) were published in an internationally indexed scientific journal, with 13.56% (<i>n</i> = 8) published in a journal with an IF≥2 and 10.18% (<i>n</i> = 6) in a Q1 category journal.</p><p><strong>Discussion: </strong>In low-income countries, the nexus between education and scientific output is multifaceted. While education serves as a critical catalyst, numerous challenges constrain the expansion of research. These nations contribute a mere 2% of global scientific production, despite confronting significant public health issues, underscoring a notable discrepancy between educational attainment and research productivity. The disparities in scientific output across universities in Latin America, Asia, and Europe are shaped by a confluence of cultural and economic determinants. In conclusion, 22.36% of the documents submitted to obtain the second professional specialty title and the master's and doctoral degrees by postgraduate dentistry students at a private Peruvian university over seven years were published in scientific journals.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"5 ","pages":"1494435"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing two large data repositories to understand the differences in demographics, health history, and behavioral attributes in populations.","authors":"Nihmath Nasiha Maliq, Toan Ong, Zachary Giano, William Rivera, Tamanna Tiwari","doi":"10.3389/froh.2024.1427109","DOIUrl":"10.3389/froh.2024.1427109","url":null,"abstract":"<p><strong>Introduction: </strong>This study conducted a comparative analysis between two large data repositories, the All of Us (AoU) medical data and BigMouth dental data repositories.</p><p><strong>Methods: </strong>The comparison analysis includes variables related to behavioral and systemic health, health literacy, and overall health status across race, ethnicity, and gender. The analytic approach used descriptive statistics, Chi-square, odds ratio, and 95% confidence intervals; significant comparisons were measured with Cohen's D effect sizes.</p><p><strong>Results: </strong>In the AoU dataset, 80.6% of Hispanic or Latino participants reported alcohol use compared to 16.8% in the BigMouth data repository. The female cohort in AoU showed 87.9% alcohol use, a contrast to BigMouth's 26.0%. Additionally, the diabetes prevalence among females was 8.8% in AoU vs. 21.6% in BigMouth. Differences in health literacy were observed, with 49.2% among Hispanic or Latino participants in AoU, in contrast to BigMouth's 3.2%. Despite this, 70.1% of Hispanic or Latino respondents in AoU reported satisfactory health status, while BigMouth indicated a much higher figure at 98.3%.</p><p><strong>Discussion: </strong>These variations highlight the importance of targeted health interventions addressing racial/ethnic and gender influences. Differences may arise from recruitment approaches, participant demographics, and healthcare access. There is a need for collaboration, standardized data collection, and inclusive recruitment to remedy these discrepancies. Further research is imperative to understand the underlying causes, facilitate interventions that address the disparities, and advocate for a more inclusive healthcare system.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"5 ","pages":"1427109"},"PeriodicalIF":3.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: single low-dose of denosumab as a trigger of MRONJ development in a patient with osteoporosis after bisphosphonate therapy.","authors":"Dávid Száraz, Vojtěch Peřina, Jana Treglerová, Ctirad Macháček, Ondřej Zendulka, Petra Bořilová Linhartová","doi":"10.3389/froh.2024.1473049","DOIUrl":"10.3389/froh.2024.1473049","url":null,"abstract":"<p><p>Both denosumab (DMB) and bisphosphonates (BPs), antiresorptive drugs (ARDs) used for the treatment of osteoporosis and oncological disorders, are known for their potential to cause medication-related osteonecrosis of the jaws (MRONJ). Besides ARDs, statins were recently associated with MRONJ development, especially in patients taking higher doses of statins for a longer period of time. Here, we report a case of a female patient with osteoporosis using statins and treated with alendronate for 3 years who rapidly developed MRONJ stage III after only a single low dose of DMB. After partial maxillectomy complete healing was observed without any recurrence. We performed a literature review of cases with MRONJ triggered by a single low dose of DMB, with or without previous application of other ARDs. Only six similar cases of patients who developed MRONJ after a single low dose of DMB following previous BP therapy have been reported so far. Besides these, literature reports one patient who developed MRONJ after a single dose of DMB following romosozumab treatment and five cases developing MRONJ after a single dose of DMB even without any previous ARD treatment. We suggest that before DMB therapy is initiated, all factors predisposing to MRONJ development should be considered.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"5 ","pages":"1473049"},"PeriodicalIF":3.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}