European journal of microbiology & immunology最新文献_第4页

Association between asymptomatic Plasmodium falciparum malaria infection, anaemia and mean corpuscular volume of school children in the Volta Region of Ghana. 加纳沃尔特地区学龄儿童无症状恶性疟原虫疟疾感染、贫血和平均血球容积之间的关系。

European journal of microbiology & immunology Pub Date : 2024-02-26 Print Date: 2024-05-14 DOI: 10.1556/1886.2024.00007

Verner N Orish, Sylvester Y Lokpo, Precious K Kwadzokpui, Rufai Safianu, Aleksandra Marinkovic, Stephanie Prakash, Chuku Okorie, Ricardo Izurieta, Rajashree Pandit, Adekunle Sanyaolu

{"title":"Association between asymptomatic Plasmodium falciparum malaria infection, anaemia and mean corpuscular volume of school children in the Volta Region of Ghana.","authors":"Verner N Orish, Sylvester Y Lokpo, Precious K Kwadzokpui, Rufai Safianu, Aleksandra Marinkovic, Stephanie Prakash, Chuku Okorie, Ricardo Izurieta, Rajashree Pandit, Adekunle Sanyaolu","doi":"10.1556/1886.2024.00007","DOIUrl":"10.1556/1886.2024.00007","url":null,"abstract":"Background: Although, several studies have reported abnormal Mean Corpuscular Volume (MCV) values and anaemia associated with malaria infections with a focus on Plasmodium falciparum among patients with complicated and uncomplicated malaria, none has looked at the association with asymptomatic malaria. This study aimed to assess this association.Methods: We conducted a cross-sectional study using 3 mL of blood samples from 549 children aged 5-17 years attending 5 schools selected in the Volta Region. Semi-structured questionnaires were administered to the children to obtain demographic data. Blood samples were collected to estimate the children's full blood count (FBC) and malaria status. Data obtained were analysed using STATA 15 software. P-values of less than 0.05 were considered statistically significant.Results: Most of the children in this study (49.9%) had normal MCV (81.3-91.3 fL) with an overall malaria prevalence of 55.6 % (95% CI: 51.3-59.8) and anaemia prevalence of 48.6% (95% CI 44.4-52.9). Most anaemic children had normal MCV (81.3-91.3 fL) (49.8, 95% CI 43.7-56.0). The predicted probability of malaria was highly likely among children with normal MCV (81.3-91.3 fL) but with high variability and uncertainty among those with low MCV (<81.3 fL) and high MCV (>91.3 fL).Conclusion: This study shows a reduced predicted probability of malaria among children with low and high MCV, playing a protective function against malaria. Further studies are required to elucidate the interaction.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"195-201"},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of a new HLA-A*0201-restricted cytotoxic T lymphocyte epitope from TC2N. 从 TC2N 中鉴定出新的 HLA-A*0201 限制性细胞毒性 T 淋巴细胞表位。

European journal of microbiology & immunology Pub Date : 2024-02-15 Print Date: 2024-02-23 DOI: 10.1556/1886.2024.00002

Zhao Yang, Hongchuan Zhang, Xiaohui Xia, Jiangwei Zhang

{"title":"Identification of a new HLA-A*0201-restricted cytotoxic T lymphocyte epitope from TC2N.","authors":"Zhao Yang, Hongchuan Zhang, Xiaohui Xia, Jiangwei Zhang","doi":"10.1556/1886.2024.00002","DOIUrl":"10.1556/1886.2024.00002","url":null,"abstract":"Identification of cytotoxic T lymphocyte (CTL) epitopes from tumor related antigens is a promising approach for malignant tumor immunotherapy. TC2N, a recently identified tumor associated antigen from human glioblastoma, is regarded as a promising target of tumor-specific immunotherapy. As one of the most widely used histocompatibility molecules in Chinese is HLA-A*0201, we were able to identify the TC2N peptides that are provided by this molecular type. A panel of antigenic peptides produced from TC2N were predicted by using a computer tool. The binding affinities of three peptides with the highest predicted score to the HLA-A*0201 molecule were evaluated after synthesis. In vitro and in vivo stimulation of the main T-cell response against the predicted peptides. The results demonstrated that TC2N (152-160) was able to release IFN-γ and lyse U251 cells in vitro as well as in vivo by eliciting peptide-specific CTLs. Our results indicated that peptide TC2N (152-160) (RLYGSVCDL) was a novel HLA-A2.1-restricted CTL epitope capable of inducing TC2N specific CTLs in vitro. As TC2N might qualify as a viable target for immunotherapeutic approaches for patients with GBM, we speculated that the newly identified epitope RLYGSVCDL would be of potential use in peptide-based, cancer-specific immunotherapy against GBM.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"59-65"},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of autophagy in killing of mycobacterial pathogens by host macrophages - Effects of some medicinal plants. 自噬在宿主巨噬细胞杀死分枝杆菌病原体中的作用--一些药用植物的影响。

European journal of microbiology & immunology Pub Date : 2024-02-13 Print Date: 2024-02-23 DOI: 10.1556/1886.2023.00062

Yutaka Tatano, Toshiaki Shimizu, Chiaki Sano, Haruaki Tomioka

{"title":"Roles of autophagy in killing of mycobacterial pathogens by host macrophages - Effects of some medicinal plants.","authors":"Yutaka Tatano, Toshiaki Shimizu, Chiaki Sano, Haruaki Tomioka","doi":"10.1556/1886.2023.00062","DOIUrl":"10.1556/1886.2023.00062","url":null,"abstract":"Autophagy is a cellular stress-induced intracellular process, through which damaged cellular components are decomposed via lysosomal degradation. This process plays important roles in host innate immunity, particularly the elimination of intracellular pathogens inside host macrophages. A more detailed understanding of the roles of autophagic events in the effective manifestation of macrophagic antimycobacterial activity is needed. Furthermore, the effects of medicinal plants on macrophagic autophagy response to mycobacterial infection need to be clarified. We herein examined the significance of autophagic events in the manifestation of host immunity during mycobacterial infection, by performing a literature search using PubMed. Recent studies demonstrated that autophagy up-regulated macrophage functions related to the intracellular killing of mycobacteria, even when pathogens were residing within the cytoplasm of macrophages. The majority of medicinal plants potentiated macrophagic autophagy, thereby enhancing their antimycobacterial functions. In contrast, most medicinal plants down-regulate the development and activation of the Th17 cell population, which reduces macrophage antimycobacterial activity. These opposing effects of medicinal plants on macrophage autophagy (enhancement) and Th17 cell functions (inhibition) may provide a plausible explanation for the clinical observation of their modest efficacy in the treatment of mycobacterial infections.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"26-36"},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and clinical potential of phage therapy in treating methicillin-resistant Staphylococcus aureus (MRSA) infections: A review. 噬菌体疗法治疗耐甲氧西林金黄色葡萄球菌（MRSA）感染的疗效和临床潜力：综述。

European journal of microbiology & immunology Pub Date : 2024-02-02 Print Date: 2024-02-23 DOI: 10.1556/1886.2023.00064

Jamil Allen G Fortaleza, Christian Joseph N Ong, Rener De Jesus

{"title":"Efficacy and clinical potential of phage therapy in treating methicillin-resistant Staphylococcus aureus (MRSA) infections: A review.","authors":"Jamil Allen G Fortaleza, Christian Joseph N Ong, Rener De Jesus","doi":"10.1556/1886.2023.00064","DOIUrl":"10.1556/1886.2023.00064","url":null,"abstract":"Staphylococcus aureus infections have already presented a substantial public health challenge, encompassing different clinical manifestations, ranging from bacteremia to sepsis and multi-organ failures. Among these infections, methicillin-resistant S. aureus (MRSA) is particularly alarming due to its well-documented resistance to multiple classes of antibiotics, contributing significantly to global mortality rates. Consequently, the urgent need for effective treatment options has prompted a growing interest in exploring phage therapy as a potential non-antibiotic treatment against MRSA infections. Phages represent a class of highly specific bacterial viruses known for their ability to infect certain bacterial strains. This review paper explores the clinical potential of phages as a treatment for MRSA infections due to their low toxicity and auto-dosing capabilities. The paper also discusses the synergistic effect of phage-antibiotic combination (PAC) and the promising results from in vitro and animal model studies, which could lead to extensive human clinical trials. However, clinicians need to establish and adhere to standard protocols governing phage administration and implementation. Prominent clinical trials are needed to develop and advance phage therapy as a non-antibiotic therapy intervention, meeting regulatory guidelines, logistical requirements, and ethical considerations, potentially revolutionizing the treatment of MRSA infections.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"13-25"},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modelling of doxycycline-based prevention of bacterial sexually transmitted infections in comparison to condom-based and test-based prevention. 基于强力霉素的细菌性传播感染预防模型与基于安全套和检测的预防方法的比较。

European journal of microbiology & immunology Pub Date : 2024-01-30 Print Date: 2024-02-23 DOI: 10.1556/1886.2023.00059

Andreas Hahn, Hagen Frickmann, Ulrike Loderstädt

{"title":"Modelling of doxycycline-based prevention of bacterial sexually transmitted infections in comparison to condom-based and test-based prevention.","authors":"Andreas Hahn, Hagen Frickmann, Ulrike Loderstädt","doi":"10.1556/1886.2023.00059","DOIUrl":"10.1556/1886.2023.00059","url":null,"abstract":"Background: Doxycycline-based prevention of bacterial sexually transmitted infections (STIs) has been assessed in various studies and has been recommended by the European AIDS Clinical Society to be proposed to persons with repeated STIs on a case-by-case basis. However, while good preventive effects could be shown for Chlamydia trachomatis and Treponema pallidum in Europe, no reliable prevention against doxycycline resistance-affected bacterial causes of STIs like Neisseria gonorrhoeae and Mycoplasma genitalium was confirmed.Methods: In a modelling-approach, we assessed potential beneficial effects even against the latter microorganisms in case of optimized adherence with doxycycline prevention. These effects were modelled for Germany in comparison to traditional prevention schemes like condom-based STI-prevention and testing-as-prevention.Results: With estimated risk reduction in the ranges of 86% for N. gonorrhoeae and of 82% for Mycoplasma genitalium, expectable preventive efficacy similar to alternative preventive approaches could be calculated in case of optimized adherence with doxycycline prevention. In case of repeated risk exposure, the preventive potential of condom-based prevention was decreased compared to both optimized doxycycline prevention and testing-as-prevention.Conclusions: As suggested by the applied modelling, the preventive effect of optimized doxycycline prevention against bacterial STIs is in a similar range, like other common prevention strategies.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"50-58"},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139577255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phage therapy in lung infections caused by multidrug-resistant Pseudomonas aeruginosa - A literature review. 噬菌体疗法治疗耐多药铜绿假单胞菌引起的肺部感染--文献综述。

European journal of microbiology & immunology Pub Date : 2024-01-23 Print Date: 2024-02-23 DOI: 10.1556/1886.2023.00060

Vincent A Eiselt, Stefan Bereswill, Markus M Heimesaat

{"title":"Phage therapy in lung infections caused by multidrug-resistant Pseudomonas aeruginosa - A literature review.","authors":"Vincent A Eiselt, Stefan Bereswill, Markus M Heimesaat","doi":"10.1556/1886.2023.00060","DOIUrl":"10.1556/1886.2023.00060","url":null,"abstract":"Pulmonary infections of patients with cystic fibrosis (CF) or in intensive care units are frequently caused by the Gram-negative opportunistic pathogen Pseudomonas aeruginosa. Since these bacteria are commonly inherently multidrug-resistant (MDR) and hence, antibiotic treatment options are limited, bacteriophages may provide alternative therapeutic and prophylactic measures in the combat of pneumonia caused by P. aeruginosa. This prompted us to perform a comprehensive literature survey of current knowledge regarding effects of phages applied against pulmonary P. aeruginosa infections. The included 23 studies revealed that P. aeruginosa specific phages lyse and eliminate the bacteria even in case of biofilm production in vitro, whereas application to mice and men resulted in mitigated P. aeruginosa induced clinical signs and enhanced survival. Besides distinct host immune responses, no major adverse effects limiting therapeutic and/or prophylactic phage application were noted. However, the immune system and antibiotics generate synergies with phages due to the mutable sensitivity of P. aeruginosa. In conclusion, results summarized in this review provide evidence that phages constitute promising alternative treatment options for lung infections caused by MDR P. aeruginosa. Further studies are needed, however, to underscore the efficacy and safety aspects of phages application to infected patients including immune-compromised individuals.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139522420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Better chance of survival is associated with higher neutrophil CD16 expression in patients with complicated intra-abdominal infections. 复杂腹腔内感染患者的存活几率与中性粒细胞 CD16 表达较高有关。

European journal of microbiology & immunology Pub Date : 2024-01-17 Print Date: 2024-02-23 DOI: 10.1556/1886.2023.00046

Evgeni Dimitrov, Krasimira Halacheva, Georgi Minkov, Emil Enchev, Yovcho Yovtchev

{"title":"Better chance of survival is associated with higher neutrophil CD16 expression in patients with complicated intra-abdominal infections.","authors":"Evgeni Dimitrov, Krasimira Halacheva, Georgi Minkov, Emil Enchev, Yovcho Yovtchev","doi":"10.1556/1886.2023.00046","DOIUrl":"10.1556/1886.2023.00046","url":null,"abstract":"Aim: The ability of neutrophil CD16 (nCD16) expression to predict outcome in complicated intra-abdominal infections (cIAIs) has not yet been studied; therefore we aimed to evaluate its potential prognostic value in such patients.Methods: Between November 2018 and August 2021 a single-center prospective study was performed in the Department of Surgical Diseases at a University Hospital Stara Zagora. A flow cytometry was used to measure the levels of nCD16 before surgery and on the 3rd postoperative day (POD) in 62 patients with cIAIs.Results: We observed a mortality rate of 14.5% during hospitalization. Survivors had significantly higher perioperative expression of nCD16 than non-survivors (P = 0.02 preoperatively and P = 0.006 postoperatively). As predictor of favorable outcome we found a good predictive performance of preoperative nCD16 (AUROC = 0.745) and a very good predictive performance of postoperative levels (AUROC = 0.846). An optimal preoperative threshold nCD16 = 34.75 MFI permitted prediction of survival with sensitivity and specificity of 66.7% and 77.8%, respectively. A better sensitivity of 72.5% and specificity of 85.7% were observed for threshold = 54.8 MFI on the 3rd POD.Conclusion: Perioperative neutrophil CD16 expression shows a great potential as a predictor of favorable outcome in patients with cIAIs.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study. ABO 和 Rh 血型与弓形虫感染的关系：一项横断面研究。

European journal of microbiology & immunology Pub Date : 2024-01-12 Print Date: 2024-02-23 DOI: 10.1556/1886.2023.00052

Alma Rosa Pérez-Álamos, Marisela Aguilar-Durán, Sergio Estrada Martínez, Agar Ramos-Nevárez, Carlos Alberto Guido-Arreola, Antonio Sifuentes-Álvarez, Sandra Margarita Cerrillo-Soto, Raúl Graciano Ibarra, Cosme Alvarado-Esquivel

{"title":"Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study.","authors":"Alma Rosa Pérez-Álamos, Marisela Aguilar-Durán, Sergio Estrada Martínez, Agar Ramos-Nevárez, Carlos Alberto Guido-Arreola, Antonio Sifuentes-Álvarez, Sandra Margarita Cerrillo-Soto, Raúl Graciano Ibarra, Cosme Alvarado-Esquivel","doi":"10.1556/1886.2023.00052","DOIUrl":"10.1556/1886.2023.00052","url":null,"abstract":"We aimed to determine the association between the seropositivity to Toxoplasma gondii and the ABO and Rh blood groups in 2,053 people. ABO and Rhesus blood groups and anti-T. gondii IgG and IgM antibodies were determined using commercially available assays. Of the 2,053 people studied, 171 (8.3%) were positive for anti-T. gondii IgG antibodies. Sixty-five (38.0%) and 36 (21.1%) of these 171 individuals had high anti-T. gondii IgG antibody levels (≥150 IU mL-1) and anti-T. gondii IgM antibodies, respectively. We found the following prevalences of T. gondii infection among the ABO groups: 8.5% in group A, 4.3% in group B, 4.7% in group AB, and 8.9% in group O (P = 0.19). The prevalences of T. gondii infection among Rh groups were: 8.4% in the Rh-positive group and 7.1% in the Rh-negative group (P = 0.58). Logistic regression analysis showed that the frequencies of ABO and Rh blood groups were similar (P > 0.05) among people with positive and negative serology for anti-T. gondii IgG antibodies, with high (≥150 IU mL-1) and lower (<150 IU mL-1) levels of anti-T. gondii IgG antibodies, and with positive and negative serology for anti-T. gondii IgM antibodies. Results does not support an association between T. gondii infection and ABO and Rh blood groups.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"44-49"},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139428091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prophylactic oral application of resveratrol to alleviate acute campylobacteriosis in human gut microbiota associated IL-10-/- mice. 预防性口服白藜芦醇可缓解与人类肠道微生物群相关的 IL-10-/- 小鼠的急性弯曲杆菌病。

European journal of microbiology & immunology Pub Date : 2023-12-15 Print Date: 2023-12-21 DOI: 10.1556/1886.2023.00042

Markus M Heimesaat, Niklas Schabbel, Luis Q Langfeld, Nizar W Shayya, Soraya Mousavi, Stefan Bereswill

{"title":"Prophylactic oral application of resveratrol to alleviate acute campylobacteriosis in human gut microbiota associated IL-10-/- mice.","authors":"Markus M Heimesaat, Niklas Schabbel, Luis Q Langfeld, Nizar W Shayya, Soraya Mousavi, Stefan Bereswill","doi":"10.1556/1886.2023.00042","DOIUrl":"10.1556/1886.2023.00042","url":null,"abstract":"Human infections with the food-borne zoonotic enteropathogen Campylobacter jejuni are increasing globally. Since multi-drug resistant bacterial strains are further on the rise, antibiotic-independent measures are needed to fight campylobacteriosis. Given its anti-microbial and anti-inflammatory properties the polyphenolic compound resveratrol constitutes such a promising candidate molecule. In our present placebo-controlled intervention trial, synthetic resveratrol was applied perorally to human gut microbiota-associated (hma) IL-10-/- mice starting a week before oral C. jejuni infection. Our analyses revealed that the resveratrol prophylaxis did not interfere with the establishment of C. jejuni within the murine gastrointestinal tract on day 6 post-infection, but alleviated clinical signs of campylobacteriosis and resulted in less distinct colonic epithelial apoptosis. Furthermore, oral resveratrol dampened C. jejuni-induced colonic T and B cell responses as well as intestinal secretion of pro-inflammatory mediators including nitric oxide, IL-6, TNF-α, and IFN-γ to basal levels. Moreover, resveratrol application was not accompanied by significant shifts in the colonic commensal microbiota composition during campylobacteriosis in hma IL-10-/- mice. In conclusion, our placebo-controlled intervention study provides evidence that prophylactic oral application of resveratrol constitutes a promising strategy to alleviate acute campylobacteriosis and in consequence, to reduce the risk for post-infectious autoimmune sequelae.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"135-149"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10755668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Campylobacter in Africa - A specific viewpoint. 非洲的弯曲杆菌--一种特殊观点。

European journal of microbiology & immunology Pub Date : 2023-12-05 Print Date: 2023-12-21 DOI: 10.1556/1886.2023.00043

Ellis Kobina Paintsil, Wycliffe O Masanta, Annika Dreyer, Leonid Ushanov, Stella I Smith, Hagen Frickmann, Andreas E Zautner

{"title":"Campylobacter in Africa - A specific viewpoint.","authors":"Ellis Kobina Paintsil, Wycliffe O Masanta, Annika Dreyer, Leonid Ushanov, Stella I Smith, Hagen Frickmann, Andreas E Zautner","doi":"10.1556/1886.2023.00043","DOIUrl":"10.1556/1886.2023.00043","url":null,"abstract":"Campylobacter infections and campylobacteriosis-associated post-infectious sequelae are a significant global health burden that needs to be addressed from a specific African perspective. We conducted a comprehensive literature search on NCBI PubMed to compile a comprehensive narrative review article on Campylobacter infections in Africa, focusing on key aspects in human and veterinary medicine as well as food hygiene. We specifically focused on the epidemiology of enteropathogenic Campylobacter spp. in sub-Saharan and North Africa considering antimicrobial susceptibility. The most significant sequela resulting from molecular mimicry to Campylobacter surface structures is the Guillain-Barré syndrome, which was mainly examined in the context of limited studies conducted in African populations. A dedicated subsection is allocated to the limited research on the veterinary medically important species Campylobacter fetus. There are significant differences in the composition of the gut microbiome, especially in rural areas, which affect the colonization with Campylobacter spp. and the manifestation of campylobacteriosis. There may be a problem of overdiagnosis due to asymptomatic colonization, particularly in the detection of Campylobacter using molecular biological techniques. To reduce the colonization and infection rate of Campylobacter, we propose implementing several control measures and urge further research to improve the current understanding of the peculiarities of campylobacteriosis in Africa.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"107-124"},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10755667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138489399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0